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medium_hidden_intermediate_05477 | Hepacivirus C upregulates a gene that enables RNA binding. Evidence for one such gene in hepatocytes (from study GSE132606) reports a log2 fold change of 1.086 and an adjusted p-value of 0.002711. Which disease is associated with this gene through genomic alterations? | melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05477","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables RNA binding. Evidence for one such gene in hepatocytes (from study GSE132606) ... | |
medium_hidden_intermediate_05478 | Two genes are structurally linked to Human immunodeficiency virus 1 via an 'upregulates' relationship and to RNA binding via an 'enables' relationship. One of these genes has a reported log2 fold change of 1.697 and an adjusted p-value of 0.003037 in a specific study. Which cell type is this specific gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05478","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via an 'upregulates' relationship and to RNA binding via... | |
medium_hidden_intermediate_05479 | Hepacivirus C upregulates a gene that is located in a protein-containing complex. Evidence for this gene reports a log2 fold change of 1.105 and an adjusted p-value of 0.002524. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05479","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is located in a protein-containing complex. Evidence for this gene reports a log2 fold... | |
medium_hidden_intermediate_05481 | Two genes are structurally linked to Hepacivirus C via downregulation and to CTIF via interaction. One of these genes exhibits a log2 fold change of -1.302 and an adjusted p-value of 0.0004179 in a specific study. Which cell type is enriched for this specific gene? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05481","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Hepacivirus C via downregulation and to CTIF via interaction. One of these genes exhibi... | |
medium_hidden_intermediate_05482 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with RAD51. One of these genes shows a log2 fold change of approximately 3.86 and an adjusted p-value of 0.014 in bronchial epithelial cells. Which disease is associated with this specific gene as a biomarker? | colorectal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05482","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with RAD51. One of these gen... | |
medium_hidden_intermediate_05483 | Two genes are upregulated by Human immunodeficiency virus 1 and associated with colitis. One of these genes exhibits a log2 fold change of 2.757 and an adjusted p-value of 0.0002555 in macrophages (study GSE108897). Which disease is linked to this specific gene via a biomarker relationship? | intrahepatic cholangiocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05483","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and associated with colitis. One of these genes exhibits a log2 ... | |
medium_hidden_intermediate_05485 | Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to breast carcinoma via an association relationship. One of these genes is reported in a study (GSE117668) involving pleural mesothelioma cells, with a log2 fold change of approximately 1.295 and an adjusted p-value of appro... | Protein BTG3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05485","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to breast carcinoma via an a... | |
medium_hidden_intermediate_05486 | Human immunodeficiency virus 1 upregulates a gene that is involved in endosome to lysosome transport. Evidence for one such gene reports a log2 fold change of approximately 1.44 and an adjusted p-value of 0.01159. Which protein is encoded by that gene? | Sorting nexin-16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05486","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in endosome to lysosome transport. Evidence for one such ... | |
medium_hidden_intermediate_05488 | Two genes are structurally linked to Pegivirus C via downregulation and to acute myeloid leukemia via association. One of these genes exhibits a log2 fold change of -1.351 and an adjusted p-value of 0.003624 in the specified dataset. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05488","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to acute myeloid leukemia via association. One of th... | |
medium_hidden_intermediate_05490 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with HSP90AA1. One of these genes exhibits a log2 fold change of 2.784 and an adjusted p-value of 0.007491 in a specific study. Which disease is associated with this gene? | spermatogenic failure 41 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05490","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with HSP90AA1. One of these ... | |
medium_hidden_intermediate_05491 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes whose products are located in the plasma membrane. One such gene exhibits a log2 fold change of approximately -1.276 and an adjusted p-value of 0.01521. Which protein is encoded by this specific gene? | TRPM8 channel associated factor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05491","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes whose... | |
medium_hidden_intermediate_05493 | Hepacivirus C is reported to upregulate a specific gene, which is subsequently found to be enriched in non-classical monocytes. Experimental data for this gene indicates a log2 fold change of approximately 1.67 and an adjusted p-value of 0.002563. Which protein does this gene product interact with? | TFRC | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05493","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a specific gene, which is subsequently found to be enriched in non-classical monocyt... | |
medium_hidden_intermediate_05495 | In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and involved in SLC-mediated transmembrane transport showed a log2 fold change of 2.911 and an adjusted p-value of 0.01397. Which disease is associated with genomic alterations in this specific gene? | anemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05495","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and involved in SLC-mediated tra... | |
medium_hidden_intermediate_05497 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and involved in heterochromatin formation. This gene exhibits a log2 fold change of 1.615 and an adjusted p-value of 3.008e-10. Which cellular component is this gene located in? | pericentric heterochromatin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05497","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_05499 | Two genes are structurally linked to Human immunodeficiency virus 1 via an 'upregulates' relationship and to RNA polymerase II cis-regulatory region sequence-specific DNA binding via an 'enables' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 2.52 and a... | SDHA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05499","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via an 'upregulates' relationship and to RNA polymerase ... | |
medium_hidden_intermediate_05500 | Human betaherpesvirus 5 is reported to downregulate a gene that is enriched in basophils. Evidence for one such gene reports a log2 fold change of -1.507 and an adjusted p-value of 0.001463. Which protein is encoded by that gene? | Phorbol-12-myristate-13-acetate-induced protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05500","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is enriched in basophils. Evidence for one such gene reports... | |
medium_hidden_intermediate_05501 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in calcium-mediated signaling. Evidence for this gene reports a log2 fold change of 6.197 and an adjusted p-value of 0.005604. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05501","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in calcium-mediated signaling. Evi... | |
medium_hidden_intermediate_05503 | Hepacivirus C is reported to downregulate a gene that participates in biological oxidations. In a study of peripheral blood mononuclear cells (GSE119117), one such gene showed a log2 fold change of -1.316 and an adjusted p-value of 0.0464. Which disease is associated with this gene as a biomarker? | stroke disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05503","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that participates in biological oxidations. In a study of peripheral blood ... | |
medium_hidden_intermediate_05505 | In a study of cervical adenocarcinoma cells (GSE11238), a gene is downregulated by Vaccinia virus and interacts with YWHAH. This specific gene exhibits a log2 fold change of -2.124 and an adjusted p-value of 0.0322. Which cellular component is this gene located in? | adherens junction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05505","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), a gene is downregulated by Vaccinia virus and interacts with YWHAH. ... | |
medium_hidden_intermediate_05506 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved in the Pentose phosphate pathway. One such gene exhibited a log2 fold change of approximately 1.99 and an adjusted p-value of approximately 9.18e-13. Which protein is encoded by this specific gen... | Deoxyribose-phosphate aldolase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05506","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved... | |
medium_hidden_intermediate_05507 | Measles morbillivirus downregulates a gene that participates in cell-cell communication. Evidence for one such gene reports a log2 fold change of -1.856 and an adjusted p-value of 0.0003515. Which disease is associated with this gene as a biomarker? | mammary neoplasms, animal | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05507","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that participates in cell-cell communication. Evidence for one such gene reports ... | |
medium_hidden_intermediate_05508 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycosphingolipid catabolism. Experimental data for this gene shows a log2 fold change of -1.274 and an adjusted p-value of 0.008868. Which protein is encoded by this gene? | Beta-galactosidase-1-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05508","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycosphingolipid catab... | |
medium_hidden_intermediate_05509 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with FBXO10. This gene exhibited a log2 fold change of approximately 2.32 and an adjusted p-value of 1.702e-06. Which protein is encoded by this gene? | Serine/threonine-protein phosphatase PGAM5, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05509","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_05510 | Human alphaherpesvirus 1 upregulates a gene that participates in the Unfolded Protein Response (UPR). In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of approximately 1.90 and an adjusted p-value of 0.0061. Which disease is associated with this specific gene? | sensorineural hearing loss disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05510","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in the Unfolded Protein Response (UPR). In a study of monocyti... | |
medium_hidden_intermediate_05511 | Zika virus downregulates a gene that binds to SNAPC2. In glioma stem cells, one such gene exhibits a log2 fold change of approximately -2.035 and an adjusted p-value of 0.003662. Which protein is encoded by this gene? | Integrator complex subunit 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05511","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that binds to SNAPC2. In glioma stem cells, one such gene exhibits a log2 fold change of app... | |
medium_hidden_intermediate_05512 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to invasive breast carcinoma via an association relationship. One of these genes has a reported log2 fold change of -1.622 and an adjusted p-value of 0.03061. Which protein is encoded by this specific gen... | Breast cancer anti-estrogen resistance protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05512","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to invas... | |
medium_hidden_intermediate_05513 | A protein is expressed in Natural killer T (NKT) cells and physically interacts with BRCA1. Experimental evidence indicates that this protein directly binds to the amino-terminal region of BRCA1 and to γ-tubulin. Which biological process is this protein involved in? | ATP metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05513","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein is expressed in Natural killer T (NKT) cells and physically interacts with BRCA1. Experimental evidence indicates ... | |
medium_hidden_intermediate_05516 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Interleukin-1 family signaling. Experimental data for this gene in bronchial epithelial cells reports a log2 fold change of approximately 4.37 and an adjusted p-value of approximately 0.037. Which cell type is this gene e... | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05516","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Interleukin-1 family sign... | |
medium_hidden_intermediate_05518 | Zika virus downregulates a gene that is located in the nucleoplasm. Experimental data from glioma stem cells (study GSE114907) indicates that this specific gene has a log2 fold change of -2.624 and an adjusted p-value of 0.01128. Which protein is encoded by this gene? | Nuclear exosome regulator NRDE2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05518","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the nucleoplasm. Experimental data from glioma stem cells (study GSE11490... | |
medium_hidden_intermediate_05519 | Human alphaherpesvirus 3 is reported to downregulate a specific gene, which is in turn enriched in memory B cells. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene has a log2 fold change of -1.429 and an adjusted p-value of 2.607e-05. Which protein is encoded by this gene? | Cell division cycle-associated 7-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05519","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is reported to downregulate a specific gene, which is in turn enriched in memory B cells. Experimen... | |
medium_hidden_intermediate_05520 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and localized to the cytoplasm. Experimental data for this gene reports a log2 fold change of approximately -1.037 and an adjusted p-value of 0.001871. Which disease is associated with genomic alterations in this specific gene? | rheumatoid arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05520","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and localized to the cytoplasm. Exp... | |
medium_hidden_intermediate_05522 | Human betaherpesvirus 5 is reported to downregulate a specific gene that participates in Developmental Biology. Experimental data for this gene in foreskin fibroblast cell lines (study GSE111036) show a log2 fold change of -1.020 and an adjusted p-value of 0.04313. Which molecular function is enabled by this gene? | sequence-specific double-stranded DNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05522","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene that participates in Developmental Biology. Experimental... | |
medium_hidden_intermediate_05523 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and involved in intracellular iron ion homeostasis. This gene exhibits a log2 fold change of approximately 1.94 and an adjusted p-value of approximately 1.69e-11. Which protein is encoded by this gene? | Glutaredoxin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05523","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and involved in int... | |
medium_hidden_intermediate_05524 | Zika virus downregulates a gene that participates in Antigen processing: Ubiquitination & Proteasome degradation. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.554 and an adjusted p-value of 0.01457. Which protein is encoded by this specific gene? | Thimet oligopeptidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05524","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Antigen processing: Ubiquitination & Proteasome degradation. In a study... | |
medium_hidden_intermediate_05525 | Human betaherpesvirus 5 upregulates a gene that is involved in the positive regulation of tyrosine phosphorylation of STAT protein. Evidence for this gene reports a log2 fold change of 4.789 and an adjusted p-value of 0.01403. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05525","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is involved in the positive regulation of tyrosine phosphorylation of STAT p... | |
medium_hidden_intermediate_05526 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ubiquitin protein ligase binding. Evidence for this gene reports a log2 fold change of 3.725 and an adjusted p-value of 0.02604. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05526","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ubiquitin protein ligase binding.... | |
medium_hidden_intermediate_05530 | Human immunodeficiency virus 1 downregulates a gene that participates in Signaling by WNT. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately -1.901 and an adjusted p-value of 0.02564. Which protein is encoded by this gene? | Disheveled-associated activator of morphogenesis 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05530","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in Signaling by WNT. Evidence for this gene in macroph... | |
medium_hidden_intermediate_05532 | A gene is downregulated by Human immunodeficiency virus 1 and enables enzyme binding. Evidence for this gene in a specific study (GSE108897) reports a log2 fold change of approximately -1.52 and an adjusted p-value of approximately 0.0304. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05532","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human immunodeficiency virus 1 and enables enzyme binding. Evidence for this gene in a specific s... | |
medium_hidden_intermediate_05534 | Zika virus downregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -2.14 and an adjusted p-value of approximately 0.007. Which protein does this gen... | TMPRSS4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05534","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Experimen... | |
medium_hidden_intermediate_05537 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to interact with RPA2 was found to have a log2 fold change of 1.107 and an adjusted p-value of 0.0413. What molecular function is enabled by this specific gene? | microtubule binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05537","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to interact with... | |
medium_hidden_intermediate_05538 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables actin binding. Experimental data for this gene reports a log2 fold change of 4.466 and an adjusted p-value of 0.03446. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05538","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables actin binding. Experimental data ... | |
medium_hidden_intermediate_05539 | Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of autophagosome assembly. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this specific gene has a log2 fold change of approximately -1.129 and an adjusted p-value of 0.0016. Which... | CALM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05539","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of autophagosome assembly. Experi... | |
medium_hidden_intermediate_05540 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to gastric adenocarcinoma via association. One of these genes has a reported log2 fold change of 1.262 and an adjusted p-value of 0.04487. Which protein is encoded by this specific gene? | Epoxide hydrolase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05540","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to gastric adenocarcinoma... | |
medium_hidden_intermediate_05541 | Hepacivirus C upregulates a gene that participates in the Innate Immune System. Experimental data for this gene reports a log2 fold change of 2.059 and an adjusted p-value of 1.802e-05. Which protein is encoded by this gene? | Membrane-spanning 4-domains subfamily A member 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05541","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the Innate Immune System. Experimental data for this gene reports a lo... | |
medium_hidden_intermediate_05542 | Cardiovirus A downregulates a gene that enables guanyl-nucleotide exchange factor activity. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibits a log2 fold change of approximately -1.49 and an adjusted p-value of 0.0183. Which protein is encoded by this specific gene? | Protein ECT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05542","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that enables guanyl-nucleotide exchange factor activity. In a study of cervical adenocarc... | |
medium_hidden_intermediate_05543 | Fluconazole interacts with a specific drug, which in turn interacts with Naloxegol. Clinical evidence indicates that dose modification is necessary when this intermediate drug is used in combination with fluconazole and amiodarone. What disease is this intermediate drug indicated for? | tuberculosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05543","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Fluconazole interacts with a specific drug, which in turn interacts with Naloxegol. Clinical evidence indicates that dose mo... | |
medium_hidden_intermediate_05547 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and binds to STAT3. This gene exhibits a log2 fold change of -1.244 and an adjusted p-value of 0.005335. Which protein is encoded by this gene? | Kinesin-1 heavy chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05547","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and binds to STAT3. Thi... | |
medium_hidden_intermediate_05550 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is upregulated by the virus and its protein product binds to SRSF3. This gene exhibits a log2 fold change of 3.838 and an adjusted p-value of 0.00141. Which protein is encoded by this gene? | Splicing factor Cactin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05550","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is upregulated by the virus and its protei... | |
medium_hidden_intermediate_05551 | Two genes are upregulated by Vaccinia virus and associated with glioma. One of these genes shows a log2 fold change of 1.904 and an adjusted p-value of 1.347e-10 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is encoded by this specific gene? | Nucleoside diphosphate kinase 6, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05551","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with glioma. One of these genes shows a log2 fold change of 1.904... | |
medium_hidden_intermediate_05553 | Human alphaherpesvirus 1 upregulates a specific gene that is enriched in basophils. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 2.620 and an adjusted p-value of 0.003694. Which biological process is this gene involved in? | chromatin organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05553","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a specific gene that is enriched in basophils. Evidence for this gene in a monocytic le... | |
medium_hidden_intermediate_05556 | Rhinovirus A infection upregulates certain genes that subsequently interact with CCNF. One such gene exhibits a log2 fold change of approximately 1.073 and an adjusted p-value of 0.000389 in cytotoxic T-lymphocytes. Which protein is encoded by this specific gene? | Tudor-interacting repair regulator protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05556","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection upregulates certain genes that subsequently interact with CCNF. One such gene exhibits a log2 fold ch... | |
medium_hidden_intermediate_05558 | Human alphaherpesvirus 3 upregulates a gene that participates in the Respiratory Syncytial Virus Infection Pathway. Evidence for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of 3.625 and an adjusted p-value of 2.619e-06. Which protein is encoded by this gene? | Interferon alpha-5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05558","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that participates in the Respiratory Syncytial Virus Infection Pathway. Evidence... | |
medium_hidden_intermediate_05561 | Human immunodeficiency virus 1 upregulates a gene that enables signaling receptor binding. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 1.69 and an adjusted p-value of 0.003975. Which disease is associated with this gene as a biomarker? | delirium | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05561","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables signaling receptor binding. In a study of macrophages (GSE108... | |
medium_hidden_intermediate_05562 | Hepacivirus C downregulates a gene that is involved in cell-cell signaling. Evidence for this gene in natural killer cells from study GSE125686 reports a log2 fold change of approximately -2.28 and an adjusted p-value of 0.0226. Which cell type is this gene enriched in? | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05562","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that is involved in cell-cell signaling. Evidence for this gene in natural killer cells f... | |
medium_hidden_intermediate_05563 | A gene is upregulated by Measles morbillivirus and located in chromatin. Experimental data for this gene shows a log2 fold change of approximately 1.096 and an adjusted p-value of 0.004924. Which disease is associated with this gene? | infectious mononucleosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05563","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and located in chromatin. Experimental data for this gene shows a log2 fold c... | |
medium_hidden_intermediate_05568 | Two distinct drugs are structurally linked between Lepirudin and Moexipril via interaction relationships. One of these drugs has documented evidence of being administered concomitantly with Lepirudin. Which disease is indicated for that specific drug? | myocardial infarction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05568","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are structurally linked between Lepirudin and Moexipril via interaction relationships. One of these drugs... | |
medium_hidden_intermediate_05570 | Pegivirus C is reported to downregulate a gene that subsequently interacts with GOLPH3L. In a study of peripheral blood mononuclear cells (GSE131504), one such intermediate gene exhibited a log2 fold change of -1.545 and an adjusted p-value of 0.002355. Which protein is encoded by this specific gene? | Golgi apparatus protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05570","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that subsequently interacts with GOLPH3L. In a study of peripheral blood mono... | |
medium_hidden_intermediate_05571 | Zika virus upregulates a specific gene, which is subsequently found to be enriched in Mucosa-associated invariant T (MAIT) cells. Experimental data for this gene in neural stem cells reports a log2 fold change of 2.772 and an adjusted p-value of 0.02466. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05571","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene, which is subsequently found to be enriched in Mucosa-associated invariant T (MAIT) c... | |
medium_hidden_intermediate_05572 | A gene is downregulated by Primate bocaparvovirus 1 and is located in the extracellular exosome. Evidence for this gene reports a log2 fold change of -1.365 and an adjusted p-value of 0.02754. Which disease is associated with this gene as a biomarker? | leiomyoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05572","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is located in the extracellular exosome. Evidence for this gene repo... | |
medium_hidden_intermediate_05573 | In a study of non-small cell lung adenocarcinoma, a gene downregulated by Influenza A virus and enriched in plasmacytoid dendritic cells showed a log2 fold change of -1.305 and an adjusted p-value of 1.135e-10. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05573","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma, a gene downregulated by Influenza A virus and enriched in plasmacytoid den... | |
medium_hidden_intermediate_05575 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with TRAF6. Experimental data for this gene reports a log2 fold change of -2.156 and an adjusted p-value of 0.01848. Which disease is associated with this gene through genomic alterations? | X-linked hypohidrotic ectodermal dysplasia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05575","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with TRAF6. Experimental data... | |
medium_hidden_intermediate_05576 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the ER Quality Control Compartment (ERQC). Evidence for one such gene reports a log2 fold change of 1.234 and an adjusted p-value of 0.02347. Which protein is encoded by that gene? | UDP-glucose:glycoprotein glucosyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05576","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the ER Quality Control Compart... | |
medium_hidden_intermediate_05579 | Two distinct genes form a binding bridge between DIS3 and ZFP36. One of these genes is supported by evidence stating: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which cell type is this specific gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05579","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct genes form a binding bridge between DIS3 and ZFP36. One of these genes is supported by evidence stating: 'Here,... | |
medium_hidden_intermediate_05581 | Pegivirus C is reported to downregulate a gene that subsequently interacts with BTRC. Experimental data for one such intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of -1.126 and an adjusted p-value of 0.04493. Which protein is encoded by this specific gene? | Forkhead box protein N2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05581","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that subsequently interacts with BTRC. Experimental data for one such interme... | |
medium_hidden_intermediate_05582 | Enterovirus A upregulates a gene that interacts with RBBP7. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) show a log2 fold change of 1.825 and an adjusted p-value of 3.003e-06. Which biological process is this gene involved in? | negative regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05582","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that interacts with RBBP7. Experimental data for this gene in rhabdomyosarcoma cells (study... | |
medium_hidden_intermediate_05583 | Human immunodeficiency virus 1 upregulates a gene that participates in the Innate Immune System. Evidence for one such gene reports a log2 fold change of 2.622 and an adjusted p-value of 0.005554. Which protein is encoded by that gene? | Chitinase-3-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05583","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the Innate Immune System. Evidence for one such gene ... | |
medium_hidden_intermediate_05584 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of certain genes whose products are located in extracellular exosomes. One such gene exhibits a log2 fold change of -1.075 and an adjusted p-value of 0.02443. Which protein is encoded by this specific gene? | Small VCP/p97-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05584","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of certain... | |
medium_hidden_intermediate_05585 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in factors involved in megakaryocyte development and platelet production. Evidence for this gene reports a log2 fold change of 3.568 and an adjusted p-value of 1.085e-11. Which cell type is this gene enriched in? | peripheral blood mononuclear cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05585","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in factors involved in megakaryoc... | |
medium_hidden_intermediate_05586 | Zika virus upregulates a gene that participates in cellular responses to stress. Evidence for this gene reports a log2 fold change of 1.971 and an adjusted p-value of 0.02935. Which protein is encoded by this gene? | Glutathione-specific gamma-glutamylcyclotransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05586","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in cellular responses to stress. Evidence for this gene reports a log2 fold ... | |
medium_hidden_intermediate_05587 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in Phase II - Conjugation of compounds. Evidence for this gene reports a log2 fold change of 1.385 and an adjusted p-value of 0.0003339. Which biological process is this gene involved in? | glutathione metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05587","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participat... | |
medium_hidden_intermediate_05588 | A gene is downregulated by Human gammaherpesvirus 8 and is associated with aneuploidy. Experimental data for this gene reports a log2 fold change of -1.607 and an adjusted p-value of 0.03857. Which protein is encoded by this gene? | Dual specificity protein kinase TTK | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05588","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and is associated with aneuploidy. Experimental data for this gene repor... | |
medium_hidden_intermediate_05592 | Measles morbillivirus downregulates a gene that is located in the nucleus. Evidence for this specific gene reports a log2 fold change of -1.155 and an adjusted p-value of 2.731e-05. Which disease is associated with this gene? | astrocytoma (excluding glioblastoma) | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05592","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that is located in the nucleus. Evidence for this specific gene reports a log2 fo... | |
medium_hidden_intermediate_05593 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to dental caries via an association relationship. One of these genes exhibits a log2 fold change of -2.942 and an adjusted p-value of 0.002161 in macrophages (study GSE108897). Which protein is encoded by the gene ... | Leucine-rich repeat-containing protein 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05593","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to dental caries v... | |
medium_hidden_intermediate_05594 | Zaire ebolavirus downregulates a gene whose product is located in the extracellular exosome. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of -1.285 and an adjusted p-value of 0.04573. Which protein is encoded by this gene? | Succinate receptor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05594","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene whose product is located in the extracellular exosome. In a study of retinal pigment e... | |
medium_hidden_intermediate_05595 | Fluconazole and Apalutamide are both known to interact with a specific intermediate drug. Pharmacokinetic evidence regarding this intermediate drug notes that increases in the AUC of a substrate associated with coadministration of an inhibitor were estimated using the equation 1/(1 - CR(CYP3A4) x IR(CYP3A4)), based on ... | anxiety | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05595","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Fluconazole and Apalutamide are both known to interact with a specific intermediate drug. Pharmacokinetic evidence regarding... | |
medium_hidden_intermediate_05597 | A gene is upregulated by Primate bocaparvovirus 1 and associated with glioblastoma. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 1.460 and an adjusted p-value of 0.02375. Which biological process is this gene involved in? | endothelial cell migration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05597","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and associated with glioblastoma. Experimental data for this gene in a non... | |
medium_hidden_intermediate_05598 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to endometrial carcinoma via an association relationship. One of these genes is reported in a study (GSE155241) with a log2 fold change of approximately -1.258 and an adjusted p-value of 0.04... | SEC14-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05598","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship... | |
medium_hidden_intermediate_05599 | Two genes are upregulated by Vaccinia virus and are involved in the regulation of the apoptotic process. One of these genes exhibits a log2 fold change of approximately 1.81 and an adjusted p-value of approximately 4.94e-10 in cervical adenocarcinoma cell lines. Which disease is associated with genomic alterations in t... | ovarian neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05599","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and are involved in the regulation of the apoptotic process. One of these genes ... | |
medium_hidden_intermediate_05600 | Hepacivirus C downregulates a gene that participates in the Immune System. Evidence for one such gene reports a log2 fold change of -1.065 and an adjusted p-value of 0.001403. Which biological process is this gene involved in? | negative regulation of toll-like receptor signaling pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05600","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that participates in the Immune System. Evidence for one such gene reports a log2 fold ch... | |
medium_hidden_intermediate_05601 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and is involved in the positive regulation of the inflammatory response. Evidence for this gene reports a log2 fold change of approximately -2.56 and an adjusted p-value of approximately 0.0099. Which protein... | Interleukin-1 beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05601","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and is invol... | |
medium_hidden_intermediate_05603 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for hepatocellular carcinoma. Evidence for this gene reports a log2 fold change of approximately -1.71 and an adjusted p-value of 0.0167. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05603","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for hepatocellula... | |
medium_hidden_intermediate_05605 | Zaire ebolavirus upregulates a gene that participates in Cytokine Signaling in the Immune system. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of 6.190 and an adjusted p-value of 0.0009178. Which protein is encoded by this gene? | Interferon-induced protein 44-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05605","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that participates in Cytokine Signaling in the Immune system. In a study of retinal pigm... | |
medium_hidden_intermediate_05606 | In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), two genes are downregulated and participate in Hemostasis. One of these genes exhibits a log2 fold change of approximately -1.33 and an adjusted p-value of approximately 0.0094. Which protein interacts with this specific gene produ... | PRKCD | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05606","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), two genes are downregulated and par... | |
medium_hidden_intermediate_05608 | CD28 interacts with a specific protein that subsequently participates in CD28-dependent PI3K/Akt signaling. Research involving site-directed mutagenesis of soluble forms of this protein and CD86 identified residues in both the IgV and IgC domains that are critical for binding to CTLA4Ig and CD28Ig. Which gene encodes t... | T-lymphocyte activation antigen CD80 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05608","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CD28 interacts with a specific protein that subsequently participates in CD28-dependent PI3K/Akt signaling. Research involvi... | |
medium_hidden_intermediate_05609 | Rhinovirus A infection is associated with the downregulation of specific genes that are enriched in non-classical monocytes. One such gene exhibits a log2 fold change of approximately -2.59 and an adjusted p-value of 0.001591 in cytotoxic T-lymphocytes (study GSE106475). Which protein is encoded by this gene? | Secreted and transmembrane protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05609","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the downregulation of specific genes that are enriched in non-classical monocytes.... | |
medium_hidden_intermediate_05610 | Two genes are upregulated by Human immunodeficiency virus 1 and are enriched in naive CD8+ T cells. One of these genes exhibits a log2 fold change of 1.216 and an adjusted p-value of 0.003905 in macrophages (study GSE108897). Which protein is encoded by this specific gene? | Inactive glycosyltransferase 25 family member 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05610","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are enriched in naive CD8+ T cells. One of these genes exhib... | |
medium_hidden_intermediate_05611 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that participates in tRNA processing. One such gene exhibited a log2 fold change of 1.056 and an adjusted p-value of 0.04655. Which protein is encoded by this specific gene? | tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05611","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that pa... | |
medium_hidden_intermediate_05614 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with the protein HIST2H2AC. Evidence for this downregulated gene reports a log2 fold change of -1.408 and an adjusted p-value of 0.03081. Which protein is encoded... | Histone PARylation factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05614","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_05615 | Zika virus downregulates a specific gene that is involved in the regulation of DNA-templated transcription. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of approximately -1.754 and an adjusted p-value of 0.003862. What molecular function is enabled by this gene? | DNA-binding transcription factor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05615","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the regulation of DNA-templated transcription. Experimental dat... | |
medium_hidden_intermediate_05618 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes that participate in the association of TriC/CCT with target proteins during biosynthesis. One such gene exhibited a log2 fold change of 1.788 and an adjusted p-value of 6.488e-07. Which protein is enco... | AP-3 complex subunit mu-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05618","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes that ... | |
medium_hidden_intermediate_05619 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. One such gene exhibits a log2 fold change of approximately 3.53 and an adjusted p-value of approximately 0.0128. Whi... | Phosphoinositide-3-kinase-interacting protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05619","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in the negative re... | |
medium_hidden_intermediate_05620 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of these genes exhibits a log2 fold change of approximately 1.67 and an adjusted p-value of approximately 0.0069 in a specific study. Which protein is encoded by this gene? | Acyl-coenzyme A synthetase ACSM3, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05620","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of th... | |
medium_hidden_intermediate_05621 | A gene interacts with KRAS and is enriched in memory CD8+ T cells. Evidence for this gene includes a mean expression of 3.53 TPM, a z-score of 2.12, and a fold enrichment of 4.65. Which disease is associated with this gene? | purpura | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05621","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene interacts with KRAS and is enriched in memory CD8+ T cells. Evidence for this gene includes a mean expression of 3.53... | |
medium_hidden_intermediate_05622 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated by the virus and interacts with SLC7A14. Evidence for this gene reports a log2 fold change of -1.320 and an adjusted p-value of 0.009571. Which protein is encoded by this gene? | NADH-cytochrome b5 reductase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05622","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated by the virus... | |
medium_hidden_intermediate_05623 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to glaucoma via association. One of these genes was reported in a study (GSE153684) with a log2 fold change of 2.423 and an adjusted p-value of 9.721e-11. Which protein is encoded by this specific gene? | Protein O-mannosyl-transferase TMTC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05623","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to glaucoma via associati... | |
medium_hidden_intermediate_05624 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the M Phase. Experimental data for this gene reports a log2 fold change of approximately 1.71 and an adjusted p-value of 0.0239. In which cell type is this gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05624","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the M Phase. Experimental... | |
medium_hidden_intermediate_05625 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein serine/threonine kinase activity. Evidence for this gene reports a log2 fold change of 1.128 and an adjusted p-value of 0.02826. Which disease is associated with this gene? | alveolar rhabdomyosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05625","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein serine/threonine kinase a... | |
medium_hidden_intermediate_05626 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which in turn interacts with PSMD4. This gene exhibits a log2 fold change of approximately 1.88 and an adjusted p-value of 0.0027. Which protein is encoded by this gene? | Ubiquilin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05626","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_05629 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which in turn participates in the formation of the anterior neural plate. Evidence for this gene reports a log2 fold change of -1.848 and an adjusted p-value of 0.0002966... | axon ensheathment | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05629","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_05630 | A gene is downregulated by Human gammaherpesvirus 8 and participates in Neutrophil degranulation. Experimental data for this gene in vascular endothelial cells (study GSE16354) shows a log2 fold change of approximately -3.20 and an adjusted p-value of 0.013. Which protein does this gene product interact with? | SYVN1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05630","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and participates in Neutrophil degranulation. Experimental data for this... |
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