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medium_hidden_intermediate_05631 | Hepacivirus C is reported to downregulate a gene that is involved in the negative regulation of transcription by RNA polymerase II. Experimental data from a study on peripheral blood mononuclear cells (GSE119117) indicates that this specific gene has a log2 fold change of approximately -1.071 and an adjusted p-value of... | Transcription factor E4F1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05631","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is involved in the negative regulation of transcription by RNA polymer... | |
medium_hidden_intermediate_05632 | SLC22A9 interacts with a specific gene product that enables protein binding. Evidence indicates that this entity enhances the binding of Herp to Hrd1, an interaction required for ERAD. Which biological process is this entity involved in? | ERAD pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05632","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"SLC22A9 interacts with a specific gene product that enables protein binding. Evidence indicates that this entity enhances th... | |
medium_hidden_intermediate_05633 | Human immunodeficiency virus 1 upregulates a gene that is involved in intracellular signal transduction. Experimental data for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately 3.001 and an adjusted p-value of 7.253e-05. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05633","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in intracellular signal transduction. Experimental data f... | |
medium_hidden_intermediate_05635 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its product binds to PPL. Evidence for this gene reports a log2 fold change of 1.761 and an adjusted p-value of 0.02979. Which protein is encoded by this gene? | Butyrophilin subfamily 3 member A1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05635","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its produc... | |
medium_hidden_intermediate_05636 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn is associated with tRNA binding activity. This gene exhibited a log2 fold change of -1.342 and an adjusted p-value of 0.0142. Which protein is encoded by this gene? | Exportin-T | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05636","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn i... | |
medium_hidden_intermediate_05641 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and involved in the regulation of inflammatory response. Evidence for this gene reports a log2 fold change of -2.175 and an adjusted p-value of 0.03096. Which protein is encoded by this gene? | Chemerin-like receptor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05641","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and involved... | |
medium_hidden_intermediate_05643 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in cytokine signaling in the immune system. This gene exhibited a log2 fold change of approximately 2.78 and an adjusted p-value of approximately 1.15e-05. Which cellular component ... | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05643","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene tha... | |
medium_hidden_intermediate_05644 | A specific thymocyte subtype is characterized by the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive. This cell type is a double negative thymocyte that contains the pre-T cell receptor complex in its plasma membrane. Which cell type does this specific thymocyte develop from? | DN3 thymocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05644","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific thymocyte subtype is characterized by the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and... | |
medium_hidden_intermediate_05645 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with open-angle glaucoma through genomic alterations. Evidence for this gene reports a log2 fold change of -3.955 and an adjusted p-value of 0.01708. Which protein is encoded by this gene? | Lysyl oxidase homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05645","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with open-angle glaucoma ... | |
medium_hidden_intermediate_05646 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to the basolateral plasma membrane via a location relationship. One of these genes exhibits a log2 fold change of -2.049 and an adjusted p-value of 0.03641 in macrophages (study GSE108897). Which disease is associa... | pulmonary edema | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05646","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to the basolateral... | |
medium_hidden_intermediate_05650 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in protein metabolism. Evidence for this gene reports a log2 fold change of approximately 1.093 and an adjusted p-value of 0.0009668. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05650","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in protein metabolis... | |
medium_hidden_intermediate_05651 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in Glycosphingolipid catabolism. One of these genes exhibits a log2 fold change of 1.478 and an adjusted p-value of 0.01742 in macrophages (study GSE108897). Which disease is associated with this specific gene as a biomarker? | bacterial meningitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05651","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in Glycosphingolipid catabolism. One of these ge... | |
medium_hidden_intermediate_05653 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a specific gene is downregulated by Human gammaherpesvirus 8 and its protein product interacts with SOD1. This gene exhibits a log2 fold change of -1.267 and an adjusted p-value of 0.0487. Which protein is encoded by this gene? | Macrophage migration inhibitory factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05653","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a specific gene is downregulated by Human gammaherpesvirus 8 and ... | |
medium_hidden_intermediate_05655 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. Transcriptomic data for this gene shows a log2 fold change of 1.042 and an adjusted p-value of 0.003368. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05655","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the proteasome-mediated ub... | |
medium_hidden_intermediate_05656 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of the cell cycle. Evidence for this gene reports a log2 fold change of 1.022 and an adjusted p-value of 0.01427. Which protein is encoded by this gene? | Mitochondrial tRNA methylthiotransferase CDK5RAP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05656","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of the ... | |
medium_hidden_intermediate_05657 | Two genes are downregulated by Pegivirus C and interact with BRCA1. One of these genes exhibits a log2 fold change of -1.992 and an adjusted p-value of 0.0002674 in peripheral blood mononuclear cells. Which disease is associated with this specific gene as a biomarker? | anti-neutrophil cytoplasmic antibody-associated vasculitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05657","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and interact with BRCA1. One of these genes exhibits a log2 fold change of -1.992... | |
medium_hidden_intermediate_05658 | Two genes are each upregulated by Vaccinia virus and associated with adenoviridae infectious disease. One of these genes exhibits a log2 fold change of 7.668 and an adjusted p-value of 2.612e-11 in cervical adenocarcinoma cell lines (study GSE11238). Which protein interacts with this specific gene? | VCP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05658","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Vaccinia virus and associated with adenoviridae infectious disease. One of these genes exh... | |
medium_hidden_intermediate_05659 | Hepacivirus C is reported to downregulate a specific gene, which is in turn associated with renal cell carcinoma. Experimental data for this gene shows a log2 fold change of -1.735 and an adjusted p-value of 0.0002557. Which protein is encoded by this gene? | Claudin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05659","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which is in turn associated with renal cell carcinoma. Experiment... | |
medium_hidden_intermediate_05661 | Cyclosporine and Idelalisib are both known to interact with a specific intermediate drug. Evidence regarding this intermediate drug states: 'The interactions between antibiotic treatment and cyclosporine therapy should be observed closely in organ transplant recipients, requiring frequent level determinations and dosin... | active tuberculosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05661","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cyclosporine and Idelalisib are both known to interact with a specific intermediate drug. Evidence regarding this intermedia... | |
medium_hidden_intermediate_05665 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its product binds to DDB1. Transcriptomic data for this gene in a cardiomyocyte cell line shows a log2 fold change of approximately 1.76 and an adjusted p-value of approximately 0.008. Which protein is encoded by this gene? | DDB1- and CUL4-associated factor 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05665","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its product binds to DDB1. Transcriptomic... | |
medium_hidden_intermediate_05666 | Cardiovirus A downregulates a gene that is located in the plasma membrane. Evidence for this specific gene reports a log2 fold change of -1.088 and an adjusted p-value of 0.04006. Which protein is encoded by this gene? | Metalloreductase STEAP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05666","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that is located in the plasma membrane. Evidence for this specific gene reports a log2 fo... | |
medium_hidden_intermediate_05667 | Vaccinia virus upregulates a gene that participates in cell surface interactions at the vascular wall. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibited a log2 fold change of 3.215 and an adjusted p-value of 2.346e-09. Which protein is encoded by this specific gene? | Lymphocyte function-associated antigen 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05667","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that participates in cell surface interactions at the vascular wall. In a study of cervica... | |
medium_hidden_intermediate_05668 | Hepacivirus C downregulates multiple genes that enable guanyl-nucleotide exchange factor activity. One such gene exhibits a log2 fold change of approximately -1.006 and an adjusted p-value of 2.124e-05 in natural killer cells. Which protein is encoded by this specific gene? | Cytohesin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05668","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates multiple genes that enable guanyl-nucleotide exchange factor activity. One such gene exhibits a ... | |
medium_hidden_intermediate_05670 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and exhibits genomic alterations associated with hepatocellular carcinoma. Experimental data for this gene reports a log2 fold change of -2.446 and an adjusted p-value of 0.001284. Which disease is linked to this gene as a biomarker? | atherosclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05670","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and exhibits genomic alterations associated... | |
medium_hidden_intermediate_05671 | Cardiovirus A downregulates a gene that participates in the mitotic cell cycle. Evidence from a study on cervical adenocarcinoma cell lines (GSE122967) reports that this gene has a log2 fold change of -2.072 and an adjusted p-value of 0.01077. Which disease is associated with this gene? | aneuploidy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05671","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that participates in the mitotic cell cycle. Evidence from a study on cervical adenocarci... | |
medium_hidden_intermediate_05672 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to ZC3H12A via an interaction relationship. One of these genes was reported in a study (GSE157852) involving choroid plexus epithelium cells, with a log2 fold change of approximately 3.166 and... | chondrosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05672","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_05673 | Hepacivirus C upregulates a gene that participates in deubiquitination. Evidence for this gene reports a log2 fold change of 1.106 and an adjusted p-value of 0.005949. Which cellular component is this gene located in? | Ino80 complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05673","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in deubiquitination. Evidence for this gene reports a log2 fold change of... | |
medium_hidden_intermediate_05674 | In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and is associated with hyperplasia. Experimental data for this gene reports a log2 fold change of -1.091 and an adjusted p-value of 0.0007635. Which protein is encoded by this gene? | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05674","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and is associated with hyperpla... | |
medium_hidden_intermediate_05675 | Hepacivirus C upregulates a gene that is involved in the MAPK cascade. Evidence for one such gene reports a log2 fold change of 1.309 and an adjusted p-value of 0.02778. Which disease is associated with this gene as a biomarker? | cerebral infarction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05675","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the MAPK cascade. Evidence for one such gene reports a log2 fold change... | |
medium_hidden_intermediate_05676 | In a study of cytotoxic T-lymphocytes (GSE106475), Human orthopneumovirus infection was found to upregulate a specific gene that enables protein binding. This gene exhibited a log2 fold change of approximately 1.21 and an adjusted p-value of approximately 0.038. Which protein is encoded by this gene? | Secretogranin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05676","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cytotoxic T-lymphocytes (GSE106475), Human orthopneumovirus infection was found to upregulate a specific gene ... | |
medium_hidden_intermediate_05677 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the positive regulation of endothelial cell proliferation. Evidence for this gene in lung tissue reports a log2 fold change of -4.018 and an adjusted p-value of 0.004225. Which disease is associated with this gene? | chronic rhinosinusitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05677","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the positive regulation of en... | |
medium_hidden_intermediate_05678 | A gene is downregulated by Primate bocaparvovirus 1 and is involved in the positive regulation of the inflammatory response. Experimental evidence for this gene reports a log2 fold change of -1.387 and an adjusted p-value of 0.01548. Which protein is encoded by this gene? | NF-kappa-B inhibitor zeta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05678","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is involved in the positive regulation of the inflammatory response.... | |
medium_hidden_intermediate_05682 | Two genes are structurally linked in a pathway starting from Human immunodeficiency virus 1 (via downregulation) and ending at fibrosarcoma (via association). One of these genes was reported in a study (GSE108897, macrophages) with a log2 fold change of -2.412 and an adjusted p-value of 0.02616. Which protein is encode... | Musculin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05682","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked in a pathway starting from Human immunodeficiency virus 1 (via downregulation) and ending ... | |
medium_hidden_intermediate_05683 | Pegivirus C is reported to downregulate a gene that is associated with sarcoma. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibits a log2 fold change of approximately -1.079 and an adjusted p-value of 0.015. Which protein is encoded by this specific gene? | Bcl-2-like protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05683","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is associated with sarcoma. In a study of peripheral blood mononuclear c... | |
medium_hidden_intermediate_05684 | Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of DNA-templated transcription. Experimental data from a study on macrophages (GSE108897) indicates that this specific gene exhibits a log2 fold change of 2.392 and an adjusted p-value of 3.946e-05. Which protein is encoded by... | Zinc fingers and homeoboxes protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05684","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of DNA-templated transcription... | |
medium_hidden_intermediate_05685 | Enterovirus A is reported to downregulate a gene that is located in a protein-containing complex. In a study of rhabdomyosarcoma cells (GSE103308), one such gene exhibits a log2 fold change of approximately -1.62 and an adjusted p-value of approximately 0.0028. Which protein is encoded by this gene? | Alpha-crystallin B chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05685","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a gene that is located in a protein-containing complex. In a study of rhabdomyosar... | |
medium_hidden_intermediate_05686 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Acyl chain remodelling of PC. Evidence for this gene reports a log2 fold change of -1.281 and an adjusted p-value of 0.04931. Which disease is associated with this gene? | mitochondrial myopathy-lactic acidosis-deafness syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05686","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Acyl chain remodelling ... | |
medium_hidden_intermediate_05687 | Hepacivirus C is reported to upregulate a gene that is located in the cornified envelope. One such gene exhibits a log2 fold change of 1.017 and an adjusted p-value of 0.0002114 in a specific study. Which protein is encoded by this gene? | Kazrin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05687","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is located in the cornified envelope. One such gene exhibits a log2 fold... | |
medium_hidden_intermediate_05688 | Human immunodeficiency virus 1 downregulates a gene that is involved in the positive regulation of transcription by RNA polymerase II. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately -3.46 and an adjusted p-value of 0.01036. Which protein does this gene interact with? | TLE1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05688","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the positive regulation of transcription by RNA poly... | |
medium_hidden_intermediate_05689 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in dendrite morphogenesis. Experimental data for this gene shows a log2 fold change of 1.356 and an adjusted p-value of 0.01918. Which protein is encoded by this gene? | Microtubule-associated protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05689","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in dendrite morphogenesis. Ex... | |
medium_hidden_intermediate_05690 | Zika virus downregulates a gene that binds to PEX14. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -2.11 and an adjusted p-value of 0.0148. Which protein is encoded by this gene? | Lon protease homolog 2, peroxisomal | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05690","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that binds to PEX14. Experimental data from glioma stem cells (study GSE114907) indicates th... | |
medium_hidden_intermediate_05693 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables tau protein binding. Experimental data for this gene in a cardiomyocyte cell line (study GSE151879) shows a log2 fold change of 1.320 and an adjusted p-value of 0.00602. Which disease is associated with this gene as a biomarker? | colorectal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05693","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables tau protein binding. Experimental... | |
medium_hidden_intermediate_05695 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the mitochondrial nucleoid. Evidence for one such gene reports a log2 fold change of 1.227 and an adjusted p-value of 0.02833. Which protein is encoded by that gene? | ATP synthase F(1) complex subunit beta, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05695","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the mitochondrial nucleoid. Evid... | |
medium_hidden_intermediate_05697 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Axon guidance. Evidence for this gene reports a log2 fold change of 1.268 and an adjusted p-value of 0.00705. Which molecular function is enabled by this gene? | sequence-specific double-stranded DNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05697","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Axon guidance. Evidence f... | |
medium_hidden_intermediate_05699 | Human immunodeficiency virus 1 downregulates a specific gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for this gene reports a log2 fold change of -1.495 and an adjusted p-value of 0.02057. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05699","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a specific gene that is enriched in Mucosa-associated invariant T (MAIT) cells.... | |
medium_hidden_intermediate_05700 | Human immunodeficiency virus 1 downregulates a specific gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.416 and an adjusted p-value of 0.007045. Which cellular component is this gene locat... | Cul3-RING ubiquitin ligase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05700","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a specific gene that is involved in the proteasome-mediated ubiquitin-dependent... | |
medium_hidden_intermediate_05701 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to upregulate genes that enable electron transfer activity. One such gene exhibited a log2 fold change of approximately 3.89 and an adjusted p-value of 0.001687. Which protein is encoded by this specific gene? | 17-beta-hydroxysteroid dehydrogenase type 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05701","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to upregulate genes that ena... | |
medium_hidden_intermediate_05702 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in nervous system development. One of these genes was reported in a study (GSE155241) on lung cells with a log2 fold change of 1.785 and an adjusted p-value of 0.04222. Which disease is associated with this specific gene... | sarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05702","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in nervous system develo... | |
medium_hidden_intermediate_05703 | Human alphaherpesvirus 1 upregulates a gene that is enriched in basophils. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 3.049 and an adjusted p-value of 0.008535. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05703","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is enriched in basophils. Evidence for this gene in a monocytic leukemia ce... | |
medium_hidden_intermediate_05705 | A gene is downregulated by Measles morbillivirus and located in the nucleus. Experimental data for this gene reports a log2 fold change of -1.353 and an adjusted p-value of 0.01671. Which disease is associated with this gene as a biomarker? | esophageal squamous cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05705","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and located in the nucleus. Experimental data for this gene reports a log2 ... | |
medium_hidden_intermediate_05707 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is upregulated by Pegivirus C and enables protein binding. This gene exhibits a log2 fold change of 1.886 and an adjusted p-value of 0.04714. Which protein is encoded by this gene? | Protein S100-P | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05707","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is upregulated by Pegivirus C and enables protein bindi... | |
medium_hidden_intermediate_05709 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in phosphate-containing compound metabolic process. One of these genes was reported in a study (GSE164073) using sclera cells, with a log2 fold change of approximately 1.78 and an adjusted p-value of approximately 0.0092... | acylphosphatase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05709","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in phosphate-containing ... | |
medium_hidden_intermediate_05711 | Zika virus downregulates a gene that participates in glycerophospholipid biosynthesis. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.04 and an adjusted p-value of approximately 0.032. Which disease is associated with this gene? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05711","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in glycerophospholipid biosynthesis. In a study of glioma stem cells (GSE1... | |
medium_hidden_intermediate_05714 | Enterovirus A is reported to downregulate a specific gene, which is in turn associated with carcinoma. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) indicate a log2 fold change of approximately -1.04 and an adjusted p-value of 0.0259. Which protein is encoded by this gene? | Neurotrimin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05714","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene, which is in turn associated with carcinoma. Experimental data for... | |
medium_hidden_intermediate_05715 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that participates in neutrophil degranulation. This gene exhibited a log2 fold change of -2.056 and an adjusted p-value of 0.005168. Which protein interacts with this downregulated gene? | LGALS3BP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05715","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_05718 | Enterovirus A is reported to upregulate a specific gene, which is in turn enriched in non-classical monocytes. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) indicates a log2 fold change of 3.034 and an adjusted p-value of 0.03348. Which protein is encoded by this gene? | G protein-coupled receptor kinase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05718","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to upregulate a specific gene, which is in turn enriched in non-classical monocytes. Experimental ... | |
medium_hidden_intermediate_05719 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to schizophrenia via biomarker association. One of these genes was reported in a study of lung adenocarcinoma cell lines (GSE147507) with a log2 fold change of approximately 1.535 and an adjusted p-value of 0.04679. Which... | Phosphatidylinositol 4-kinase type 2-beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05719","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to schizophrenia via biom... | |
medium_hidden_intermediate_05720 | Human alphaherpesvirus 3 is reported to upregulate a gene that is enriched in intermediate monocytes. Evidence for this specific gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately 1.41 and an adjusted p-value of approximately 2.83e-05. Which protein is encoded by this gene? | FERM domain containing 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05720","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is reported to upregulate a gene that is enriched in intermediate monocytes. Evidence for this spec... | |
medium_hidden_intermediate_05721 | In a study of colonic adenocarcinoma cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated and involved in tRNA C3-cytosine methylation. This gene exhibits a log2 fold change of approximately 1.023 and an adjusted p-value of 0.02256. Which protein is encoded by this g... | tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05721","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of colonic adenocarcinoma cells infected with Severe acute respiratory syndrome-related coronavirus, a specific g... | |
medium_hidden_intermediate_05722 | Pegivirus C downregulates a gene that is involved in rRNA processing. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.24 and an adjusted p-value of approximately 0.00084. What molecular function is enabled by this specific gene? | RNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05722","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that is involved in rRNA processing. In a study of peripheral blood mononuclear cells (GSE1... | |
medium_hidden_intermediate_05723 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and interacts with RAB11A. This gene exhibits a log2 fold change of approximately 1.123 and an adjusted p-value of 0.02384. Which protein is encoded by this gene? | Rab11 family-interacting protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05723","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and interacts w... | |
medium_hidden_intermediate_05724 | EXOSC9 interacts with a protein that is localized to the nucleus. Evidence indicates that the function of this specific protein is restricted to the nucleoli. In which cell type is this protein enriched? | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05724","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"EXOSC9 interacts with a protein that is localized to the nucleus. Evidence indicates that the function of this specific prot... | |
medium_hidden_intermediate_05726 | Human immunodeficiency virus 1 downregulates a gene that interacts with YWHAE. Evidence for one such gene reports a log2 fold change of -1.230 and an adjusted p-value of 0.01434. Which biological process is that gene involved in? | basement membrane organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05726","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that interacts with YWHAE. Evidence for one such gene reports a log2 fol... | |
medium_hidden_intermediate_05727 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in cell differentiation. Experimental data for this gene reports a log2 fold change of 1.495 and an adjusted p-value of 0.01708. Which protein is encoded by this gene? | Myelin and lymphocyte protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05727","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in cell differentiation. Experimen... | |
medium_hidden_intermediate_05729 | Hepacivirus C upregulates a gene that is involved in the response to xenobiotic stimulus. Experimental data from a study on hepatocytes (GSE132606) indicates that this specific gene has a log2 fold change of approximately 3.10 and an adjusted p-value of approximately 0.00056. Which protein is encoded by this gene? | Ribonuclease P protein subunit p21 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05729","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the response to xenobiotic stimulus. Experimental data from a study on ... | |
medium_hidden_intermediate_05731 | Hepacivirus C is reported to downregulate a specific gene, which in turn interacts with ACTB. Experimental data for this gene shows a log2 fold change of approximately -1.006 and an adjusted p-value of 0.005824. Which protein is encoded by this gene? | Calponin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05731","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which in turn interacts with ACTB. Experimental data for this gen... | |
medium_hidden_intermediate_05732 | A gene is upregulated by Primate bocaparvovirus 1 and enriched in naive B cells. Experimental evidence for this gene reports a log2 fold change of approximately 1.515 and an adjusted p-value of 0.0004536. Which disease is associated with this gene? | cardiofacioneurodevelopmental syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05732","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and enriched in naive B cells. Experimental evidence for this gene reports... | |
medium_hidden_intermediate_05733 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and its product binds to GNA15. Experimental data for this gene reports a log2 fold change of -2.470 and an adjusted p-value of 0.03249. Which protein is encoded by this gene? | B1 bradykinin receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05733","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and its product binds to GNA15. Experimenta... | |
medium_hidden_intermediate_05736 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and its product is located in the extracellular matrix. Evidence for this gene reports a log2 fold change of approximately -1.15 and an adjusted p-value of 0.0007138. Which protein is encoded by this gene? | Tubulointerstitial nephritis antigen-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05736","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and its product is located in the e... | |
medium_hidden_intermediate_05737 | Hepacivirus C is reported to downregulate a gene that is located in the microtubule. Experimental data for one such gene shows a log2 fold change of approximately -2.90 and an adjusted p-value of approximately 0.0012. Which protein interacts with this specific gene product? | CEP135 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05737","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is located in the microtubule. Experimental data for one such gene sho... | |
medium_hidden_intermediate_05738 | A gene expressed in multipotent progenitor cells encodes a protein with binding activity. Evidence indicates that this protein interacts with vesicle-associated membrane protein 8 (VAMP8), a v-SNARE protein, in both human and mouse models. Which biological process is this gene involved in? | mast cell degranulation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05738","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene expressed in multipotent progenitor cells encodes a protein with binding activity. Evidence indicates that this prote... | |
medium_hidden_intermediate_05740 | Hepacivirus C downregulates a gene that is involved in the negative regulation of the apoptotic process. Experimental data from peripheral blood mononuclear cells (study GSE119117) indicate that this gene has a log2 fold change of approximately -1.525 and an adjusted p-value of 0.003873. Which protein is encoded by thi... | HIG1 domain family member 2A, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05740","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that is involved in the negative regulation of the apoptotic process. Experimental data f... | |
medium_hidden_intermediate_05742 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the immune response. Evidence for one such gene reports a log2 fold change of 1.342 and an adjusted p-value of 0.04019. Which protein is encoded by that gene? | Cystatin-F | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05742","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the immune response. Evidence f... | |
medium_hidden_intermediate_05744 | Two genes are upregulated by Vaccinia virus and associated with prostate cancer. One of these genes exhibits a log2 fold change of 2.177 and an adjusted p-value of 7.952e-05 in cervical adenocarcinoma cell lines. Which cellular component is the location of this specific gene? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05744","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with prostate cancer. One of these genes exhibits a log2 fold cha... | |
medium_hidden_intermediate_05745 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Diseases of glycosylation. One of these genes shows a log2 fold change of approximately -1.08 and an adjusted p-value of approximately 0.0066 in a specific study. Which disease is associated with this gene as a bioma... | polyarticular arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05745","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Diseases of glycosyl... | |
medium_hidden_intermediate_05746 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of certain host genes involved in protein metabolism. One such gene exhibits a log2 fold change of -1.664 and an adjusted p-value of 0.007058. Which cellular component is this specific gene located in? | Cul4-RING E3 ubiquitin ligase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05746","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of certain host... | |
medium_hidden_intermediate_05747 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene was found to be downregulated by the virus and to participate in intra-Golgi and retrograde Golgi-to-ER traffic. This gene exhibited a log2 fold change of -1.334 and an adjusted p-value of 1.547e-11. Which biological... | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05747","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene was found to be down... | |
medium_hidden_intermediate_05748 | A gene associated with Natural killer T cells via a marker relationship also interacts with RB1. Evidence regarding one such gene states: 'Ubiquitination of the protein encoded by this gene requires an intact C-terminal region that is also necessary for stable binding to p300 and pRB, two proteins that bind to the ubiq... | EP300-interacting inhibitor of differentiation 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05748","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene associated with Natural killer T cells via a marker relationship also interacts with RB1. Evidence regarding one such... | |
medium_hidden_intermediate_05749 | Pegivirus C downregulates a specific gene that enables enzyme binding. Transcriptomic data for this gene in peripheral blood mononuclear cells (study GSE131504) shows a log2 fold change of approximately -1.759 and an adjusted p-value of 0.01721. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05749","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene that enables enzyme binding. Transcriptomic data for this gene in peripheral blood... | |
medium_hidden_intermediate_05750 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables AMP kinase activity. One such gene exhibits a log2 fold change of approximately 1.48 and an adjusted p-value of 0.001065. Which protein is encoded by this specific gene? | GTP:AMP phosphotransferase AK3, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05750","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables AMP kinase activity. O... | |
medium_hidden_intermediate_05751 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified that is downregulated by Pegivirus C and binds to SCO1. This specific gene exhibits a log2 fold change of -1.271 and an adjusted p-value of 0.04764. Which disease is associated with this gene? | mitochondrial complex IV deficiency, nuclear type 23 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05751","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified that is downregulated by Pegivirus C and ... | |
medium_hidden_intermediate_05753 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the CDC42 GTPase cycle. In a specific study, this gene exhibited a log2 fold change of 2.579 and an adjusted p-value of 0.009645. Which gene interacts with this upregulated entity? | RAC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05753","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the CDC42 GTPase cycle. In a s... | |
medium_hidden_intermediate_05754 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn encodes a protein that binds to RAC1. The expression data for this gene shows a log2 fold change of approximately -1.81 and an adjusted p-value of 0.036. Which protein is encoded by this gene? | Granule associated Rac and RHOG effector protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05754","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn e... | |
medium_hidden_intermediate_05755 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Senescence-Associated Secretory Phenotype (SASP). Experimental data for this gene reports a log2 fold change of approximately 1.046 and an adjusted p-value of 0.0004226. Which protein is encoded by this gene? | Anaphase-promoting complex subunit 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05755","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Senescence-Associated... | |
medium_hidden_intermediate_05757 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the process 'TP53 Regulates Transcription of Cell Cycle Genes'. One of these genes was reported in a study on cardiomyocyte cell lines with a log2 fold change of approximately 1.44 and an adjusted p-value of 0.0134. Wh... | chromatin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05757","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the process 'TP53 Regu... | |
medium_hidden_intermediate_05761 | Zika virus downregulates a gene that is located in the mitotic spindle pole. Evidence for this specific gene reports a log2 fold change of -1.578 and an adjusted p-value of 0.01976. Which biological process is this gene involved in? | cytoplasmic microtubule organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05761","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the mitotic spindle pole. Evidence for this specific gene reports a log2 ... | |
medium_hidden_intermediate_05762 | Zika virus downregulates a gene that participates in fatty acid metabolism. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.804 and an adjusted p-value of 0.006325. Which protein is encoded by this specific gene? | 3-oxoacyl-[acyl-carrier-protein] reductase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05762","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in fatty acid metabolism. In a study of glioma stem cells (GSE114907), one... | |
medium_hidden_intermediate_05763 | Hepacivirus C is reported to upregulate a gene that subsequently interacts with HIST1H2BG. Experimental data for one such intermediate gene indicates a log2 fold change of 1.011 and an adjusted p-value of 5.497e-07. Which protein is encoded by this specific gene? | HMG box transcription factor BBX | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05763","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that subsequently interacts with HIST1H2BG. Experimental data for one such in... | |
medium_hidden_intermediate_05765 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in cilium assembly. One of these genes exhibits a log2 fold change of 4.347 and an adjusted p-value of 0.004805 in lung cells. Which disease is associated with this specific gene as a biomarker? | amyotrophic lateral sclerosis type 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05765","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in cilium assembly. One ... | |
medium_hidden_intermediate_05766 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved in Phase II conjugation of compounds. One such gene exhibited a log2 fold change of 2.627 and an adjusted p-value of 3.227e-13. Which protein is encoded by this specific gene? | Maleylacetoacetate isomerase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05766","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved... | |
medium_hidden_intermediate_05768 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to adult medulloblastoma as biomarkers. One of these genes exhibits a log2 fold change of 1.641 and an adjusted p-value of 0.04677 in a specific study. Which protein is encoded by this gene? | Activator of 90 kDa heat shock protein ATPase homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05768","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to adult medulloblastoma ... | |
medium_hidden_intermediate_05770 | Hepacivirus C is reported to downregulate multiple genes that are involved in protein modification processes. One such gene exhibits a log2 fold change of -2.184 and an adjusted p-value of 9.618e-07 in hepatocytes. Which protein is encoded by this specific gene? | F-box/LRR-repeat protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05770","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate multiple genes that are involved in protein modification processes. One such gene ... | |
medium_hidden_intermediate_05771 | Human immunodeficiency virus 1 upregulates a gene that is located on the cell surface. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 2.968 and an adjusted p-value of 0.002391. Which disease is associated with genomic alterations in this gene? | polyarticular arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05771","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located on the cell surface. Evidence for this gene in macrophages... | |
medium_hidden_intermediate_05772 | Human immunodeficiency virus 1 upregulates a gene that enables protein tyrosine kinase binding. In a study of macrophages (GSE108897), one such gene showed a log2 fold change of 2.870 and an adjusted p-value of 0.01008. Which protein is encoded by this gene? | Cas scaffolding protein family member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05772","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables protein tyrosine kinase binding. In a study of macrophages (G... | |
medium_hidden_intermediate_05773 | Human immunodeficiency virus 1 upregulates a specific gene, which is associated with a disease. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 1.44 and an adjusted p-value of approximately 0.019. Which disease is linked to this gene as a biomarker? | acute lymphoblastic leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05773","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a specific gene, which is associated with a disease. Evidence for this gene in ma... | |
medium_hidden_intermediate_05778 | Pegivirus C downregulates a gene that is located in the nucleolus. Evidence for one such gene reports a log2 fold change of -1.546 and an adjusted p-value of 0.004644. Which molecular function is enabled by that gene? | rRNA (uridine-2'-O-)-methyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05778","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that is located in the nucleolus. Evidence for one such gene reports a log2 fold change of ... | |
medium_hidden_intermediate_05779 | A gene is upregulated by Hepacivirus C and enriched in non-classical monocytes. Evidence for this gene reports a log2 fold change of 1.672 and an adjusted p-value of 0.002563. Which disease is associated with this gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05779","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and enriched in non-classical monocytes. Evidence for this gene reports a log2 fold c... | |
medium_hidden_intermediate_05780 | Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for stroke disorder. One of these genes was reported in a study of bronchial epithelial cells (GSE150819) with a log2 fold change of approximately 3.64 and an adjusted p-value of 0.0251. Which gene interacts ... | ADRB2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05780","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for stroke d... | |
medium_hidden_intermediate_05782 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which is also associated with coronary artery disorder. The expression data for this gene shows a log2 fold change of -2.860 and an adjusted p-value of 0.04277. Which pro... | Class E basic helix-loop-helix protein 22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05782","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_05783 | Measles morbillivirus upregulates a gene that is located in the Golgi membrane. Evidence for this specific gene reports a log2 fold change of 1.971 and an adjusted p-value of 0.04534. Which protein is encoded by this gene? | Inactive rhomboid protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05783","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is located in the Golgi membrane. Evidence for this specific gene reports a lo... |
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