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medium_hidden_intermediate_05784 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and participates in O-linked glycosylation. This specific gene exhibits a log2 fold change of -1.137 and an adjusted p-value of 0.02184. Which cellular component is this gene located in? | trans-Golgi network | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05784","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and part... | |
medium_hidden_intermediate_05785 | A gene is downregulated by Primate bocaparvovirus 1 and participates in peptide hormone metabolism. Transcriptomic data for this gene in tracheobronchial epithelial cells (study GSE102392) reports a log2 fold change of -1.347 and an adjusted p-value of 0.008463. Which disease is associated with this gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05785","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in peptide hormone metabolism. Transcriptomic data for ... | |
medium_hidden_intermediate_05786 | Two genes are downregulated by Cardiovirus A and participate in Phospholipid metabolism. One of these genes exhibits a log2 fold change of -1.658 and an adjusted p-value of 0.01491 in cervical adenocarcinoma cell lines. Which cell type is enriched for this specific gene? | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05786","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Cardiovirus A and participate in Phospholipid metabolism. One of these genes exhibits a log2 ... | |
medium_hidden_intermediate_05787 | Zika virus downregulates a specific gene, which in turn interacts with KIAA0753. Experimental data for this gene reports a log2 fold change of approximately -2.78 and an adjusted p-value of 0.0052. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05787","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with KIAA0753. Experimental data for this gene reports a l... | |
medium_hidden_intermediate_05791 | Two genes are upregulated by Measles morbillivirus and associated with colon carcinoma. One of these genes exhibits a log2 fold change of approximately 3.04 and an adjusted p-value of 0.0325 in study GSE131840. Which cellular component is the location of this specific gene? | chromosome, telomeric region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05791","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Measles morbillivirus and associated with colon carcinoma. One of these genes exhibits a log2 f... | |
medium_hidden_intermediate_05793 | Two genes are structurally positioned between Cardiovirus A and STK4, linked by downregulation from the virus and interaction with STK4. One of these genes exhibits a log2 fold change of -1.831 and an adjusted p-value of 0.01613 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene ... | congenital heart block | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05793","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally positioned between Cardiovirus A and STK4, linked by downregulation from the virus and interactio... | |
medium_hidden_intermediate_05794 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the PML body. Experimental data for this gene in lung cells reports a log2 fold change of approximately 1.426 and an adjusted p-value of 0.003286. Which protein is encoded by this gene? | ETS-related transcription factor Elf-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05794","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the PML body. Experimental data ... | |
medium_hidden_intermediate_05797 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in turn interacts with CDK1. This gene exhibits a log2 fold change of -1.997 and an adjusted p-value of 0.003561. Which protein is encoded by this gene? | Ubiquitin thioesterase OTU1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05797","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in t... | |
medium_hidden_intermediate_05798 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that encodes a protein binding to CCR10. Evidence for one such gene reports a log2 fold change of 2.585 and an adjusted p-value of 0.009655. Which protein is encoded by that gene? | C-C motif chemokine 26 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05798","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that encodes a protein binding to CCR10. Evidence f... | |
medium_hidden_intermediate_05799 | Zika virus downregulates a specific gene, which in turn interacts with CCNF. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.297 and an adjusted p-value of 0.01812. Which disease is associated with this gene as a biomarker? | adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05799","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with CCNF. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_05800 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene located in the Golgi membrane was found to be upregulated. The specific experimental evidence for this gene reports a log2 fold change of 1.382 and an adjusted p-value of 0.007167. Which protein is encoded by this gene? | Progestin and adipoQ receptor family member 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05800","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene located in the Golgi membrane was foun... | |
medium_hidden_intermediate_05801 | Severe acute respiratory syndrome-related coronavirus is linked to the negative regulation of inflammatory response via a gene that it downregulates and which is involved in that process. One such gene exhibits a log2 fold change of -2.129 and an adjusted p-value of 6.901e-14. Which protein is encoded by this gene? | Interleukin-1 receptor type 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05801","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is linked to the negative regulation of inflammatory response via a ge... | |
medium_hidden_intermediate_05804 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables histone H3K9 demethylase activity. Evidence for one such gene reports a log2 fold change of 1.408 and an adjusted p-value of 0.007199. Which cellular component is that gene located in? | chromatin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05804","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables histone H3K9 demethylase activity. Evi... | |
medium_hidden_intermediate_05805 | Pegivirus C is reported to downregulate a gene product that is located on the cell surface. In a study of peripheral blood mononuclear cells (GSE131504), one such entity exhibited a log2 fold change of -1.234 and an adjusted p-value of 0.03659. Which protein is encoded by this specific entity? | Triggering receptor expressed on myeloid cells 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05805","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene product that is located on the cell surface. In a study of peripheral blood m... | |
medium_hidden_intermediate_05808 | A gene serves as a marker for retinoid acid signaling-responsive fetal germ cells and is enriched in non-classical monocytes. Evidence for this gene includes a mean expression of 282.69 TPM, a z-score of 1.51, and a fold enrichment of 2.35. Which disease is associated with this gene as a biomarker? | carcinoma of liver and intrahepatic biliary tract | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05808","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for retinoid acid signaling-responsive fetal germ cells and is enriched in non-classical monocytes... | |
medium_hidden_intermediate_05810 | Human alphaherpesvirus 1 is known to downregulate certain genes that enable cysteine-type endopeptidase activity. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibited a log2 fold change of -1.020 and an adjusted p-value of 0.002513. Which protein is encoded by this specific gene? | Caspase-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05810","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is known to downregulate certain genes that enable cysteine-type endopeptidase activity. In a study... | |
medium_hidden_intermediate_05812 | Zika virus downregulates a specific gene that is enriched in conventional dendritic cells. Evidence for this gene in glioma stem cells reports a log2 fold change of approximately -2.17 and an adjusted p-value of 0.0196. Which biological process is this gene involved in? | positive regulation of translation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05812","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is enriched in conventional dendritic cells. Evidence for this gene in glioma ... | |
medium_hidden_intermediate_05813 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cellular Senescence. Experimental data for this gene reports a log2 fold change of approximately 1.001 and an adjusted p-value of 0.03269. Which protein is encoded by this gene? | Anaphase-promoting complex subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05813","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cellular Senescence. Expe... | |
medium_hidden_intermediate_05814 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Triglyceride metabolism. One of these genes exhibits a log2 fold change of -1.230 and an adjusted p-value of 0.001281 in lung tissue data from study GSE148697. Which disease is associated with this specific gene? | Charcot-Marie-Tooth disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05814","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Triglyceride metabol... | |
medium_hidden_intermediate_05815 | Pegivirus C is reported to downregulate a gene that is involved in the regulation of the mitotic cell cycle. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this specific gene has a log2 fold change of approximately -1.268 and an adjusted p-value of 0.0001952. Which gene ... | ANAPC15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05815","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the regulation of the mitotic cell cycle. Experimental da... | |
medium_hidden_intermediate_05816 | Two genes are downregulated by Pegivirus C and participate in extracellular matrix organization. One of these genes exhibits a log2 fold change of -1.317 and an adjusted p-value of 0.04285 in peripheral blood mononuclear cells. Which disease is associated with genomic alterations in this specific gene? | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05816","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and participate in extracellular matrix organization. One of these genes exhibits... | |
medium_hidden_intermediate_05818 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its product interacts with RPA2. Experimental data for this gene shows a log2 fold change of approximately 1.33 and an adjusted p-value of approximately 0.00033. Which protein is encoded by this gene? | Testis-expressed protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05818","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its product interacts with RP... | |
medium_hidden_intermediate_05820 | Measles morbillivirus infection is associated with the upregulation of a gene that participates in glycerophospholipid biosynthesis. Experimental data for this specific gene reports a log2 fold change of approximately 1.20 and an adjusted p-value of 0.0013. Which protein is encoded by this gene? | Phospholipase ABHD3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05820","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus infection is associated with the upregulation of a gene that participates in glycerophospholipid biosy... | |
medium_hidden_intermediate_05821 | Human immunodeficiency virus 1 upregulates a gene that is associated with carcinoma. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 1.21 and an adjusted p-value of approximately 0.008. Which disease is therapeutically linked to this gene? | esophageal squamous cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05821","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with carcinoma. In a study of macrophages (GSE108897), ... | |
medium_hidden_intermediate_05823 | Hepacivirus C is reported to downregulate a gene whose product is located in the extracellular region. One such gene exhibits a log2 fold change of -1.546 and an adjusted p-value of 0.009357 in a specific study. Which protein is encoded by this gene? | Urocortin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05823","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene whose product is located in the extracellular region. One such gene exhibit... | |
medium_hidden_intermediate_05824 | Human alphaherpesvirus 3 upregulates a gene that is involved in the positive regulation of the apoptotic process. Evidence for one such gene reports a log2 fold change of 1.219 and an adjusted p-value of 0.0004072. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05824","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that is involved in the positive regulation of the apoptotic process. Evidence f... | |
medium_hidden_intermediate_05825 | Pegivirus C is reported to downregulate a specific gene, which in turn encodes a protein that binds to RAB7A. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) shows a log2 fold change of approximately -2.15 and an adjusted p-value of 0.000335. What is the name of the protein encod... | Rab proteins geranylgeranyltransferase component A 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05825","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn encodes a protein that binds to RAB7A. Experimental d... | |
medium_hidden_intermediate_05826 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and its product is located in the extracellular exosome. Evidence for this specific gene reports a log2 fold change of 1.315 and an adjusted p-value of 0.03939. Which protein is encoded by this gene? | Leukocyte elastase inhibitor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05826","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and its product... | |
medium_hidden_intermediate_05827 | A gene is downregulated by Measles morbillivirus and its product is located in the cytoplasm. Experimental data for this gene shows a log2 fold change of -2.136 and an adjusted p-value of 0.004195. Which protein is encoded by this gene? | A-type potassium channel modulatory protein KCNIP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05827","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and its product is located in the cytoplasm. Experimental data for this gen... | |
medium_hidden_intermediate_05828 | Zika virus downregulates multiple genes that participate in the transport of vitamins, nucleosides, and related molecules. One such gene exhibits a log2 fold change of -1.554 and an adjusted p-value of 0.02854 in glioma stem cells. Which molecular function is enabled by this specific gene? | nucleotide-sugar transmembrane transporter activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05828","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes that participate in the transport of vitamins, nucleosides, and related molecules. O... | |
medium_hidden_intermediate_05829 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with RNF2. Experimental data for this gene reports a log2 fold change of approximately 2.835 and an adjusted p-value of 0.01542. Which disease is associated with this gene as a biomarker? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05829","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with RNF2. Experimental data fo... | |
medium_hidden_intermediate_05830 | An astrocyte marker gene enables mRNA 3'-UTR AU-rich region binding. Evidence indicates that the protein product of this gene is a member of the CCCH tandem zinc finger protein (TTP) family, which binds to AU-rich elements in the 3'-untranslated region of mRNAs to trigger their degradation. Which protein is encoded by ... | mRNA decay activator protein ZFP36L1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05830","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"An astrocyte marker gene enables mRNA 3'-UTR AU-rich region binding. Evidence indicates that the protein product of this gen... | |
medium_hidden_intermediate_05831 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A upregulates a specific gene, which in turn interacts with CLPP. This gene exhibits a log2 fold change of 1.179 and an adjusted p-value of 0.009541. Which protein does this gene bind to? | TUFM | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05831","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A upregulates a specific gene, which in turn interacts with CL... | |
medium_hidden_intermediate_05832 | Zika virus downregulates a specific gene, which in turn interacts with CUL5. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -1.208 and an adjusted p-value of 0.0102. In which cellular component is this gene located? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05832","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with CUL5. Experimental data from glioma stem cells (study... | |
medium_hidden_intermediate_05834 | In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with SMAD3. One of these genes exhibits a log2 fold change of approximately 2.076 and an adjusted p-value of 0.00427. Which protein is encoded by this specific gene? | Cbp/p300-interacting transactivator 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05834","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with SMAD3... | |
medium_hidden_intermediate_05836 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Signaling by ALK fusions and activated point mutants. One of these genes exhibits a log2 fold change of 1.133 and an adjusted p-value of 3.913e-05 in monocytes. Which cellular component is the location of this specific... | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05836","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Signaling by ALK fusio... | |
medium_hidden_intermediate_05837 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with CBL. Experimental data for this gene shows a log2 fold change of -1.515 and an adjusted p-value of 0.01441. Which disease is associated with this gene as a biomarker? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05837","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with CBL. Experimental data f... | |
medium_hidden_intermediate_05838 | Human alphaherpesvirus 1 upregulates a specific histone variant, which in turn participates in the process of HDACs deacetylating histones. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this specific entity has a log2 fold change of 2.620 and an adjusted p-value of 0.003694. Whi... | chromatin organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05838","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a specific histone variant, which in turn participates in the process of HDACs deacetyl... | |
medium_hidden_intermediate_05839 | Two genes are upregulated by Human immunodeficiency virus 1 and enable cadherin binding. One of these genes exhibits a log2 fold change of 1.405 and an adjusted p-value of 0.0001355 in macrophages (study GSE108897). Which disease is associated with this specific gene? | intellectual disability, autosomal recessive 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05839","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and enable cadherin binding. One of these genes exhibits a log2 ... | |
medium_hidden_intermediate_05840 | Pegivirus C is reported to downregulate a gene that participates in aerobic respiration and respiratory electron transport. Evidence for one such gene shows a log2 fold change of -1.271 and an adjusted p-value of 0.04764. Which disease is associated with this specific gene? | mitochondrial complex IV deficiency, nuclear type 23 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05840","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in aerobic respiration and respiratory electron transport. ... | |
medium_hidden_intermediate_05842 | Human immunodeficiency virus 1 upregulates a gene that binds to RPS27A. Experimental data for this gene in macrophages (study GSE108897) reports a log2 fold change of 2.219 and an adjusted p-value of 0.002608. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase RNF144B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05842","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that binds to RPS27A. Experimental data for this gene in macrophages (stud... | |
medium_hidden_intermediate_05844 | Hepacivirus C infection is associated with the upregulation of multiple genes, some of which encode proteins located within protein-containing complexes. One such gene exhibits a log2 fold change of approximately 1.12 and an adjusted p-value of 2.933e-08 in liver cells. Which protein is encoded by this specific gene? | Guanine nucleotide exchange factor subunit RIC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05844","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C infection is associated with the upregulation of multiple genes, some of which encode proteins located within ... | |
medium_hidden_intermediate_05845 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the metabolism of nucleotides. Evidence for this gene reports a log2 fold change of -1.582 and an adjusted p-value of 0.01399. Which gene interacts with this downregulated gene? | VIM | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05845","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the metabolism of nucleotide... | |
medium_hidden_intermediate_05846 | PRKN interacts with multiple proteins that participate in PINK1-PRKN mediated mitophagy. One such protein is identified by evidence stating: 'The three most abundant interacting proteins were the voltage-dependent anion channels 1, 2, and 3 (VDACs 1, 2, and 3), pore-forming proteins in the outer mitochondrial membrane.... | Non-selective voltage-gated ion channel VDAC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05846","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PRKN interacts with multiple proteins that participate in PINK1-PRKN mediated mitophagy. One such protein is identified by e... | |
medium_hidden_intermediate_05847 | Hepacivirus C infection is associated with the upregulation of specific genes that participate in neutrophil degranulation. One such gene exhibits a log2 fold change of 2.584 and an adjusted p-value of 2.747e-05 in liver cells. Which protein is encoded by this gene? | Defensin alpha 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05847","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C infection is associated with the upregulation of specific genes that participate in neutrophil degranulation. ... | |
medium_hidden_intermediate_05848 | Two genes are upregulated by Influenza A virus and enriched in natural killer cells. One of these genes exhibits a log2 fold change of approximately 1.12 and an adjusted p-value of 0.002165 in bronchial epithelial cells. Which disease is associated with this specific gene? | metastatic carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05848","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Influenza A virus and enriched in natural killer cells. One of these genes exhibits a log2 fold... | |
medium_hidden_intermediate_05850 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that enables unfolded protein binding. This gene exhibited a log2 fold change of -1.175 and an adjusted p-value of 0.002668. Which protein is encoded by this gene? | DnaJ homolog subfamily A member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05850","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that enables... | |
medium_hidden_intermediate_05851 | A gene is downregulated by Primate bocaparvovirus 1 and participates in the transcriptional regulation of white adipocyte differentiation. Experimental data for this gene in vascular endothelial cells (study GSE16354) reports a log2 fold change of approximately -1.292 and an adjusted p-value of 0.005812. Which protein ... | Transcription factor COE1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05851","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in the transcriptional regulation of white adipocyte di... | |
medium_hidden_intermediate_05852 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is located in the glutamatergic synapse. Evidence for this gene reports a log2 fold change of -2.564 and an adjusted p-value of 0.001326. Which biological process is this gene involved in? | chemical synaptic transmission | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05852","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is located in the glutamatergic synapse... | |
medium_hidden_intermediate_05853 | Zika virus downregulates a gene that participates in Lanosterol biosynthesis. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -1.842 and an adjusted p-value of 0.005822. Which protein is encoded by this specific gene? | Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05853","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Lanosterol biosynthesis. In a study of glioma stem cells (GSE114907), o... | |
medium_hidden_intermediate_05854 | In a study of non-small cell lung adenocarcinoma cell lines infected with Influenza A virus, a specific gene was found to be upregulated. This gene possesses zinc ion binding activity. The experimental data for this gene reports a log2 fold change of 1.278 and an adjusted p-value of 6.195e-08. Which biological process ... | transposable element silencing | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05854","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines infected with Influenza A virus, a specific gene was found to be... | |
medium_hidden_intermediate_05856 | Enterovirus A upregulates a gene that is involved in the positive regulation of cell population proliferation. In a study of rhabdomyosarcoma cells (GSE103308), one such gene exhibits a log2 fold change of approximately 1.303 and an adjusted p-value of 0.03155. Which protein does this specific gene interact with? | CDC7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05856","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that is involved in the positive regulation of cell population proliferation. In a study of... | |
medium_hidden_intermediate_05857 | Zika virus downregulates a gene that participates in Antigen processing: Ubiquitination & Proteasome degradation. Evidence for one such gene reports a log2 fold change of -3.593 and an adjusted p-value of 0.01643. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05857","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Antigen processing: Ubiquitination & Proteasome degradation. Evidence f... | |
medium_hidden_intermediate_05858 | Pegivirus C downregulates a specific gene that is involved in protein O-linked glycosylation via mannose. Evidence for this gene reports a log2 fold change of -1.626 and an adjusted p-value of 0.004141. Which cellular component is this gene located in? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05858","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene that is involved in protein O-linked glycosylation via mannose. Evidence for this ... | |
medium_hidden_intermediate_05862 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with YWHAH. This gene exhibited a log2 fold change of approximately 1.626 and an adjusted p-value of 0.001116. Which protein is encoded by this gene? | F-box/SPRY domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05862","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_05863 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that participates in GPCR downstream signalling. This gene exhibited a log2 fold change of approximately -4.14 and an adjusted p-value of 0.0268. What molecular function is enabled by this gene? | G protein-coupled receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05863","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene t... | |
medium_hidden_intermediate_05864 | Two genes are structurally linked from Human immunodeficiency virus 1 via a downregulation relationship and onward to Signaling by GPCR via a participation relationship. One of these genes is reported in study GSE108897 (macrophage data) with a log2 fold change of -5.167 and an adjusted p-value of 0.002917. Which disea... | intrahepatic cholangiocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05864","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human immunodeficiency virus 1 via a downregulation relationship and onward to Signal... | |
medium_hidden_intermediate_05865 | Vaccinia virus upregulates a gene that participates in ion influx/efflux at the host-pathogen interface. In a study of cervical adenocarcinoma cells (GSE11238), one such gene showed a log2 fold change of 2.593 and an adjusted p-value of 2.753e-05. Which protein is encoded by this specific gene? | PDZ domain-containing protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05865","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that participates in ion influx/efflux at the host-pathogen interface. In a study of cervi... | |
medium_hidden_intermediate_05866 | Zika virus upregulates a specific gene that participates in signal transduction. Experimental data for this gene in neural stem cells shows a log2 fold change of 1.270 and an adjusted p-value of 0.03676. Which disease is associated with this gene through genomic alterations? | gallbladder carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05866","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene that participates in signal transduction. Experimental data for this gene in neural s... | |
medium_hidden_intermediate_05867 | Pegivirus C is reported to downregulate a gene that is located in the ciliary basal body. Evidence for this specific gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of -1.407 and an adjusted p-value of 0.01084. Which protein is encoded by this gene? | Protein BCAP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05867","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the ciliary basal body. Evidence for this specific gene in... | |
medium_hidden_intermediate_05868 | AP1S3 binds to a specific protein that enables protein binding. Evidence indicates that MIF interacts with this protein, which is also known as the invariant chain and functions as a single-pass membrane receptor. Which disease is associated with this protein through genomic alterations? | lung neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05868","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"AP1S3 binds to a specific protein that enables protein binding. Evidence indicates that MIF interacts with this protein, whi... | |
medium_hidden_intermediate_05870 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that participates in GPCR downstream signalling. This gene exhibited a log2 fold change of -1.458 and an adjusted p-value of 0.03023. Which protein is encoded by this gene? | Cysteinyl leukotriene receptor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05870","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene t... | |
medium_hidden_intermediate_05871 | Two genes are downregulated by Human immunodeficiency virus 1 and interact with DYNLL1. One of these genes exhibits a log2 fold change of -1.031 and an adjusted p-value of 0.03526 in a specific study. Which cell type is enriched for this specific gene? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05871","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and interact with DYNLL1. One of these genes exhibits a log2 f... | |
medium_hidden_intermediate_05872 | A gene is upregulated by Vaccinia virus and is involved in autophagy. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 1.571 and an adjusted p-value of 1.568e-05. Which disease is associated with this gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05872","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and is involved in autophagy. Experimental data for this gene in a cervical adenocar... | |
medium_hidden_intermediate_05875 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with epilepsy. One of these genes exhibits a log2 fold change of 2.378 and an adjusted p-value of 0.01386 in lung tissue. Which cellular component is the location of this specific gene? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05875","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with epilepsy. One of ... | |
medium_hidden_intermediate_05876 | Hepacivirus C is associated with the downregulation of a gene that is involved in cell-cell signaling. Experimental data for this gene reports a log2 fold change of approximately -1.965 and an adjusted p-value of 0.001885. Which protein is encoded by this gene? | CCN family member 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05876","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a gene that is involved in cell-cell signaling. Experimental data for... | |
medium_hidden_intermediate_05878 | Zaire ebolavirus infection leads to the upregulation of a specific gene, which is subsequently found to be enriched in basophils. Transcriptomic data from a study on retinal pigment epithelium cells (GSE100839) indicates that this gene exhibits a log2 fold change of approximately 1.187 and an adjusted p-value of 0.0006... | Hematopoietic SH2 domain-containing protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05878","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of a specific gene, which is subsequently found to be enriched in basop... | |
medium_hidden_intermediate_05879 | Hepacivirus C upregulates a gene that is involved in chromatin remodeling. Evidence for one such gene reports a log2 fold change of 1.106 and an adjusted p-value of 0.005949. Which protein is encoded by that gene? | INO80 complex subunit E | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05879","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in chromatin remodeling. Evidence for one such gene reports a log2 fold ch... | |
medium_hidden_intermediate_05880 | Two genes are upregulated by Human immunodeficiency virus 1 and are involved in nervous system development. One of these genes exhibits a log2 fold change of approximately 1.20 and an adjusted p-value of approximately 0.00033 in macrophages (study GSE108897). Which gene interacts with the gene identified by these expre... | DPYSL2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05880","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are involved in nervous system development. One of these gen... | |
medium_hidden_intermediate_05881 | Two genes are upregulated by Vaccinia virus and associated with lymphoma. One of these genes exhibits a log2 fold change of approximately 1.406 and an adjusted p-value of 8.103e-07 in cervical adenocarcinoma cells. Which cellular component is the location of this specific gene? | podosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05881","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with lymphoma. One of these genes exhibits a log2 fold change of ... | |
medium_hidden_intermediate_05883 | A gene is downregulated by Human gammaherpesvirus 8 and is enriched in memory B cells. Experimental data for this gene in vascular endothelial cells (from study GSE16354) reports a log2 fold change of approximately -1.16 and an adjusted p-value of approximately 0.015. Which protein is encoded by this gene? | B- and T-lymphocyte attenuator | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05883","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and is enriched in memory B cells. Experimental data for this gene in va... | |
medium_hidden_intermediate_05884 | Hepacivirus C upregulates a gene that is involved in the antibacterial humoral response. Evidence for one such gene reports a log2 fold change of 4.110 and an adjusted p-value of 3.938e-05. Which protein is encoded by that gene? | Neutrophil defensin 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05884","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the antibacterial humoral response. Evidence for one such gene reports ... | |
medium_hidden_intermediate_05885 | Vaccinia virus infection upregulates multiple genes involved in intracellular zinc ion homeostasis. One such gene exhibits a log2 fold change of 2.935 and an adjusted p-value of 3.306e-15 in cervical adenocarcinoma cells. Which protein is encoded by this specific gene? | Metal cation symporter ZIP8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05885","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection upregulates multiple genes involved in intracellular zinc ion homeostasis. One such gene exhibits a... | |
medium_hidden_intermediate_05886 | Human immunodeficiency virus 1 upregulates a gene that is located in the tight junction. In a study of macrophages (GSE108897), this gene showed a log2 fold change of 3.835 and an adjusted p-value of 0.004483. Which protein is encoded by this gene? | Claudin-11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05886","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the tight junction. In a study of macrophages (GSE10889... | |
medium_hidden_intermediate_05887 | Two genes are each upregulated by Human immunodeficiency virus 1 and associated with cervical carcinoma. One of these genes exhibits a log2 fold change of 2.306 and an adjusted p-value of 0.002001 in macrophages (study GSE108897). Which gene interacts with the gene identified by these expression statistics? | MAML1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05887","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Human immunodeficiency virus 1 and associated with cervical carcinoma. One of these genes ... | |
medium_hidden_intermediate_05889 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn participates in the transcriptional activation of mitochondrial biogenesis. This gene exhibited a log2 fold change of approximately -1.477 and an adjusted p-value of 0.006929. Which protein is ... | Dimethyladenosine transferase 2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05889","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_05890 | Two genes are upregulated by Influenza A virus and participate in downstream signaling events of the B Cell Receptor (BCR). One of these genes exhibits a log2 fold change of 1.348 and an adjusted p-value of 5.303e-05 in bronchial epithelial cells. Which disease is associated with this specific gene as a biomarker? | uveal melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05890","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Influenza A virus and participate in downstream signaling events of the B Cell Receptor (BCR). ... | |
medium_hidden_intermediate_05893 | Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the negative regulation of the apoptotic process. Experimental data for one such gene, derived from foreskin fibroblast cell lines, indicates a log2 fold change of -1.395 and an adjusted p-value of 0.04639. Which protein is encoded by this s... | ADP-ribosylation factor-like protein 6-interacting protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05893","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the negative regulation of the apoptotic proc... | |
medium_hidden_intermediate_05894 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that is involved in the cellular response to hypoxia. This gene exhibited a log2 fold change of approximately 2.80 and an adjusted p-value of approximately 1.56e-05. Which protein is encoded by ... | Hypoxia-inducible lipid droplet-associated protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05894","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_05895 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes whose protein products are located in the microtubule organizing center. One such gene exhibited a log2 fold change of approximately 3.26 and an adjusted p-value of 2.20e-11. Which protein is encoded b... | Small kinetochore-associated protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05895","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes whose... | |
medium_hidden_intermediate_05896 | A protein entity is connected to GNAI1 via a binding interaction and is associated with the molecular function of protein binding. Evidence regarding this entity states: 'Both regions interact exclusively with G alpha(i1), G alpha(i2), and G alpha(i3) in their GDP-bound forms.' Which protein is encoded by the gene corr... | Regulator of G-protein signaling 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05896","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein entity is connected to GNAI1 via a binding interaction and is associated with the molecular function of protein bi... | |
medium_hidden_intermediate_05898 | Two genes are upregulated by Vaccinia virus and participate in aerobic respiration and respiratory electron transport. One of these genes exhibits a log2 fold change of 2.372 and an adjusted p-value of 1.449e-11 in cervical adenocarcinoma cells. Which cell type is enriched for this specific gene? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05898","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in aerobic respiration and respiratory electron transport. One o... | |
medium_hidden_intermediate_05900 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that participates in the metabolism of amino acids and derivatives. This gene exhibited a log2 fold change of approximately 1.797 and an adjusted p-value of 0.02406. Which biological process is this gene in... | amino acid metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05900","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that parti... | |
medium_hidden_intermediate_05902 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with the protein CLPP. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) indicates a log2 fold change of -1.003 and an adjusted p-value of 0.02278. Which protein is encoded by this gene? | Mitochondrial transcription rescue factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05902","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with the protein CLPP. Experimental data fo... | |
medium_hidden_intermediate_05904 | Zaire ebolavirus downregulates a gene that is enriched in eosinophils. Evidence for this gene in a retinal pigment epithelium cell line (study GSE100839) reports a log2 fold change of -1.372 and an adjusted p-value of 0.003859. Which protein is encoded by this gene? | G-protein coupled receptor 146 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05904","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that is enriched in eosinophils. Evidence for this gene in a retinal pigment epitheliu... | |
medium_hidden_intermediate_05905 | Human immunodeficiency virus 1 downregulates a gene that participates in the mitotic cell cycle. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.960 and an adjusted p-value of 0.01465. Which protein is encoded by this gene? | Protein lin-54 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05905","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in the mitotic cell cycle. In a study of macrophages (... | |
medium_hidden_intermediate_05906 | Zika virus is reported to downregulate a specific gene, which serves as a biomarker for malignant colon neoplasm. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.74 and an adjusted p-value of 0.0047. Which protein is encoded by this gene? | RNA demethylase ALKBH5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05906","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus is reported to downregulate a specific gene, which serves as a biomarker for malignant colon neoplasm. In a study... | |
medium_hidden_intermediate_05907 | A gene expressed in Sertoli cells encodes a protein located in the plasma membrane. Evidence indicates that this specific protein is localized to and recycled between the plasma membrane and the Golgi complex. Which cell type is enriched in this protein? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05907","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene expressed in Sertoli cells encodes a protein located in the plasma membrane. Evidence indicates that this specific pr... | |
medium_hidden_intermediate_05909 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that participates in the metabolism of amino acids and derivatives. This gene exhibited a log2 fold change of approximately 2.92 and an adjusted p-value of 0.0095. Which biological process is this gene invo... | spermatogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05909","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that parti... | |
medium_hidden_intermediate_05914 | Enterovirus A upregulates a gene that enables sequence-specific DNA binding. Evidence for one such gene reports a log2 fold change of 1.068 and an adjusted p-value of 0.003729. Which disease is associated with that gene as a biomarker? | osteoporosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05914","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that enables sequence-specific DNA binding. Evidence for one such gene reports a log2 fold ... | |
medium_hidden_intermediate_05915 | Hepacivirus C upregulates a gene that participates in the RHO GTPase cycle. In a study of hepatocytes (GSE132606), one such gene showed a log2 fold change of 2.755 and an adjusted p-value of 0.004441. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05915","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the RHO GTPase cycle. In a study of hepatocytes (GSE132606), one such ... | |
medium_hidden_intermediate_05917 | A gene serves as a marker for Exhausted CD8+ T cells and is enriched in Regulatory T (Treg) cells. Evidence for this gene includes a mean expression of 30.45 TPM, a z-score of 2.14, and a fold enrichment of 8.83. Which disease is associated with this gene? | cerebral infarction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05917","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Exhausted CD8+ T cells and is enriched in Regulatory T (Treg) cells. Evidence for this gene in... | |
medium_hidden_intermediate_05918 | Two genes are structurally linked to Human betaherpesvirus 5 via a 'downregulates' relationship and to the process 'Regulation of lipid metabolism by PPARalpha' via a 'participates in' relationship. One of these genes has been reported in a study (GSE130665) using foreskin fibroblast cell lines with a log2 fold change ... | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05918","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human betaherpesvirus 5 via a 'downregulates' relationship and to the process 'Regulati... | |
medium_hidden_intermediate_05919 | Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to protein autophosphorylation via an 'involved in' relationship. One of these genes exhibits a log2 fold change of -2.102 and an adjusted p-value of 0.01426 in a specific study. Which disease is associated with this specific gene... | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05919","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to protein autophosphorylation via... | |
medium_hidden_intermediate_05920 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the synthesis of substrates in N-glycan biosynthesis. Evidence for this gene reports a log2 fold change of 2.298 and an adjusted p-value of 0.02928. Which biological process is this gene involved in? | glycoprotein biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05920","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the synthesis of substrates in... | |
medium_hidden_intermediate_05921 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with TP53. One of these genes was reported in a study (GSE164073) involving sclera cells, with a log2 fold change of 1.040 and an adjusted p-value of 0.001051. Which disease is associated with this specific gene? | coronary artery disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05921","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with TP53. One of these gene... | |
medium_hidden_intermediate_05922 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the inflammatory response. Evidence for one such gene reports a log2 fold change of 1.833 and an adjusted p-value of 0.01768. Which protein is encoded by that gene? | Tripartite motif-containing protein 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05922","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the inflammatory response. Evid... | |
medium_hidden_intermediate_05923 | Human alphaherpesvirus 1 upregulates a gene that interacts with H3-3A. In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of 1.051 and an adjusted p-value of 0.003028. Which protein is encoded by this gene? | Centromere protein V | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05923","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that interacts with H3-3A. In a study of monocytic leukemia cell lines (GSE11496... | |
medium_hidden_intermediate_05926 | Vaccinia virus upregulates a gene that participates in Oncogene Induced Senescence. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately 2.23 and an adjusted p-value of 1.476e-09. Which protein is encoded by this gene? | Transcription factor E2F3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05926","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that participates in Oncogene Induced Senescence. Experimental data from a cervical adenoc... | |
medium_hidden_intermediate_05928 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specific gene, which in turn interacts with RTN4. This gene exhibits a log2 fold change of 3.044 and an adjusted p-value of 4.479e-12. Which protein is encoded by this upregulated gene? | Reticulon-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05928","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specifi... |
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