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medium_hidden_intermediate_05929 | In a study of peripheral blood mononuclear cells (GSE131504), Pegivirus C infection was found to downregulate a gene that enables iron-sulfur cluster binding. One such gene exhibited a log2 fold change of -1.092 and an adjusted p-value of 0.005934. Which protein is encoded by this specific gene? | Cytosolic Fe-S cluster assembly factor NUBP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05929","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), Pegivirus C infection was found to downregulate a gene that en... | |
medium_hidden_intermediate_05930 | Two genes are upregulated by Human immunodeficiency virus 1 and associated with lip and oral cavity carcinoma. One of these genes exhibits a log2 fold change of 2.446 and an adjusted p-value of 0.0005028 in macrophages (study GSE108897). Which disease is linked to this specific gene via a biomarker relationship? | major depressive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05930","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and associated with lip and oral cavity carcinoma. One of these ... | |
medium_hidden_intermediate_05931 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with KRAS. One of these genes exhibits a log2 fold change of 5.940 and an adjusted p-value of 0.008327 in a specific study. Which cellular component is the location of this specific gene? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05931","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with KRAS. One of these gene... | |
medium_hidden_intermediate_05932 | Two genes are upregulated by Human immunodeficiency virus 1 and enriched in intermediate monocytes. One of these genes exhibits a log2 fold change of 1.836 and an adjusted p-value of 0.03314 in a study of macrophages. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05932","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and enriched in intermediate monocytes. One of these genes exhib... | |
medium_hidden_intermediate_05933 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in diseases of signal transduction by growth factor receptors and second messengers. Experimental evidence for this gene shows a log2 fold change of 1.364 and an adjusted p-value of 4.583e-05. Which protein does this gene interac... | SYT16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05933","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in diseases of signal transductio... | |
medium_hidden_intermediate_05935 | Severe acute respiratory syndrome-related coronavirus upregulates a specific gene that participates in MAPK family signaling cascades. Evidence for this gene reports a log2 fold change of 3.048 and an adjusted p-value of 0.04766. Which disease is associated with this gene as a biomarker? | uveal melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05935","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a specific gene that participates in MAPK family signaling... | |
medium_hidden_intermediate_05937 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate multiple genes that participate in the RHOD GTPase cycle. One such gene exhibited a log2 fold change of approximately 1.379 and an adjusted p-value of 6.477e-07. Which protein is encoded by this ... | Rho GTPase-activating protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05937","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_05939 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the metabolism of ingested SeMet, Sec, and MeSec into H2Se. This specific gene exhibits a log2 fold change of approximately 3.11 and an adjusted p-value of approximately 0.0128. What molecular function is enabl... | histamine N-methyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05939","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the metabolism... | |
medium_hidden_intermediate_05940 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in TCR signaling. This gene exhibits a log2 fold change of 2.902 and an adjusted p-value of 0.01846. Which protein is encoded by this gene? | Immunoglobulin superfamily member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05940","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in TCR signaling... | |
medium_hidden_intermediate_05943 | Human immunodeficiency virus 1 downregulates a gene that is located in the mitochondrial inner membrane. Evidence for this specific gene reports a log2 fold change of -1.775 and an adjusted p-value of 0.01927. Which biological process is this gene involved in? | intracellular protein transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05943","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the mitochondrial inner membrane. Evidence for this s... | |
medium_hidden_intermediate_05944 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in neuron development. One of these genes was reported in a study of colonic adenocarcinoma cell lines with a log2 fold change of approximately 2.45 and an adjusted p-value of approximately 0.037. Which protein is encode... | UDP-glucose 6-dehydrogenase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05944","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in neuron development. O... | |
medium_hidden_intermediate_05945 | Human alphaherpesvirus 1 is known to downregulate certain genes that are involved in the positive regulation of DNA-templated transcription. In a study using a monocytic leukemia cell line (GSE114966), one such gene exhibited a log2 fold change of approximately -1.456 and an adjusted p-value of 0.0038. Which protein is... | Interleukin-6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05945","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is known to downregulate certain genes that are involved in the positive regulation of DNA-template... | |
medium_hidden_intermediate_05946 | Pegivirus C downregulates a gene that interacts with SNRNP70. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) shows a log2 fold change of approximately -1.835 and an adjusted p-value of 0.0006059. Which biological process is this gene involved in? | stress granule assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05946","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that interacts with SNRNP70. Experimental data for this gene in peripheral blood mononuclea... | |
medium_hidden_intermediate_05947 | Hepacivirus C upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Experimental data for this gene reports a log2 fold change of 1.766 and an adjusted p-value of 0.001689. Which molecular function is enabled by this gene? | DNA-binding transcription repressor activity, RNA polymerase II-specific | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05947","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Experime... | |
medium_hidden_intermediate_05950 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and participating in lipid metabolism. One of these genes exhibits a log2 fold change of 1.254 and an adjusted p-value of 0.004112. Which protein does this specific gene interact with? | TSHR | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05950","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and participating ... | |
medium_hidden_intermediate_05951 | Zika virus downregulates a gene that is located in the AP-type membrane coat adaptor complex. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.462 and an adjusted p-value of 0.006177. Which protein is encoded by this gene? | AP-5 complex subunit mu-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05951","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the AP-type membrane coat adaptor complex. Experimental data for this gen... | |
medium_hidden_intermediate_05952 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with AKAP1. This gene exhibited a log2 fold change of 2.411 and an adjusted p-value of 1.157e-11. Which protein is encoded by this gene? | Tetratricopeptide repeat protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05952","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_05953 | A gene serves as a marker for Natural killer T (NKT) cells and is enriched in CD8-positive, alpha-beta memory T cells. Evidence for this gene reports a mean expression of 8.69 TPM, a z-score of 1.62, and a fold enrichment of 2.14. Which disease is associated with this gene as a biomarker? | intellectual disability | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05953","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Natural killer T (NKT) cells and is enriched in CD8-positive, alpha-beta memory T cells. Evide... | |
medium_hidden_intermediate_05954 | In a study of Primate bocaparvovirus 1 infection, a gene is upregulated by the virus and participates in the Immune System. Evidence for this gene reports a log2 fold change of 1.517 and an adjusted p-value of 0.04617. Which protein is encoded by this gene? | Interleukin-1 receptor type 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05954","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Primate bocaparvovirus 1 infection, a gene is upregulated by the virus and participates in the Immune System. ... | |
medium_hidden_intermediate_05955 | Hepacivirus C is reported to downregulate a gene that enables microtubule binding. In a study of peripheral blood mononuclear cells (GSE119117), one such gene exhibits a log2 fold change of -1.117 and an adjusted p-value of 0.00821. Which protein is encoded by this specific gene? | Sperm acrosome-associated protein 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05955","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables microtubule binding. In a study of peripheral blood mononuclea... | |
medium_hidden_intermediate_05956 | Measles morbillivirus upregulates a gene that is involved in protein localization to the nucleus. Transcriptomic data for this gene shows a log2 fold change of approximately 5.48 and an adjusted p-value of 0.015. Which protein is encoded by this gene? | NUAK family SNF1-like kinase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05956","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in protein localization to the nucleus. Transcriptomic data for th... | |
medium_hidden_intermediate_05958 | Human immunodeficiency virus 1 upregulates a gene that participates in Developmental Biology. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 2.588 and an adjusted p-value of 0.009105. Which disease is causally linked to this gene? | hyperinsulinism | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05958","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in Developmental Biology. Evidence for this gene in macr... | |
medium_hidden_intermediate_05959 | Zika virus downregulates a specific gene, the product of which binds to SMC4. In glioma stem cells (study GSE114907), this gene exhibits a log2 fold change of -2.380 and an adjusted p-value of 0.006701. Which protein is encoded by this gene? | Condensin complex subunit 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05959","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, the product of which binds to SMC4. In glioma stem cells (study GSE114907), this g... | |
medium_hidden_intermediate_05961 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in axon guidance. Evidence for one such gene reports a log2 fold change of 1.267 and an adjusted p-value of 0.0003682. Which protein is encoded by that gene? | Semaphorin-3B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05961","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in axon guidance. Evidence for one... | |
medium_hidden_intermediate_05962 | In a study of hepatoma cells infected with Dengue virus (GSE110512), a specific gene was found to be upregulated by the virus and localized to the cytoplasm. This gene exhibited a log2 fold change of approximately 1.448 and an adjusted p-value of 0.01295. Which disease is associated with this gene? | hyperglycemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05962","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of hepatoma cells infected with Dengue virus (GSE110512), a specific gene was found to be upregulated by the viru... | |
medium_hidden_intermediate_05963 | In a study of Measles morbillivirus infection, a specific gene is downregulated and its expression is enriched in naive CD4+ T cells. Evidence for this gene reports a log2 fold change of approximately -1.065 and an adjusted p-value of 0.001261. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05963","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is downregulated and its expression is enriched in naive CD4+... | |
medium_hidden_intermediate_05964 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene involved in protein deubiquitination. One such gene exhibited a log2 fold change of 1.411 and an adjusted p-value of 0.0001488. Which protein is encoded by this specific gene? | Ubiquitin carboxyl-terminal hydrolase 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05964","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene involved in protein... | |
medium_hidden_intermediate_05966 | Zaire ebolavirus upregulates a gene that is enriched in neutrophils. Evidence for this gene in a retinal pigment epithelium cell line (study GSE100839) reports a log2 fold change of approximately 1.193 and an adjusted p-value of 0.0178. Which protein does this gene interact with? | STAT3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05966","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is enriched in neutrophils. Evidence for this gene in a retinal pigment epithelium ... | |
medium_hidden_intermediate_05967 | PSMA2 is involved in a biological process that is a subtype of alpha-beta T cell activation involved in immune response. Evidence for one such process describes it as the process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell, characterized by a CD4-positive, T-b... | T-helper 1 type immune response | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05967","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PSMA2 is involved in a biological process that is a subtype of alpha-beta T cell activation involved in immune response. Evi... | |
medium_hidden_intermediate_05969 | Zika virus downregulates a gene that participates in Ub-specific processing protease activity. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -1.87 and an adjusted p-value of approximately 0.0068. Which protein is encoded by this specific gene? | Transcriptional adapter 2-beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05969","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Ub-specific processing protease activity. In a study of glioma stem cel... | |
medium_hidden_intermediate_05970 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in protein localization. Evidence for this gene reports a log2 fold change of approximately 1.38 and an adjusted p-value of approximately 0.00125. Which protein is encoded by this gene? | Iron-sulfur cluster co-chaperone protein HscB | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05970","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in protein localization. Evidence... | |
medium_hidden_intermediate_05971 | In a study of cardiomyocyte cell lines (GSE151879), a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Signaling by NOTCH. This specific gene exhibits a log2 fold change of approximately 1.57 and an adjusted p-value of 0.007185. Which protein is encoded by this gene? | Notch homolog 2 N-terminal-like protein C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05971","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), a gene is upregulated by Severe acute respiratory syndrome-related coron... | |
medium_hidden_intermediate_05972 | Zika virus downregulates a gene that is associated with inborn errors of immunity. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.201 and an adjusted p-value of 0.01648. Which protein is encoded by this gene? | Protein jagunal homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05972","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is associated with inborn errors of immunity. In a study of glioma stem cells (GSE11490... | |
medium_hidden_intermediate_05973 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is identified that is upregulated by the virus and participates in nucleotide salvage. This specific gene exhibits a log2 fold change of 1.932 and an adjusted p-value of 0.01134. Which protein is encoded by this gene? | Cytidine deaminase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05973","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is identified that is upregulated by t... | |
medium_hidden_intermediate_05974 | Zika virus downregulates a specific gene that participates in the epigenetic regulation of gene expression. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.28 and an adjusted p-value of approximately 0.0255. Which protein is encoded by this gene? | Zinc finger protein 354A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05974","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the epigenetic regulation of gene expression. In a study of gl... | |
medium_hidden_intermediate_05975 | Two genes are identified as markers on Natural killer T (NKT) cells and both enable DNA binding. One of these genes encodes Oxoguanine DNA glycosylase, which initiates base excision repair (BER) of oxidized purine bases. Which disease is causally linked to this specific gene? | type 1 diabetes mellitus 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05975","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers on Natural killer T (NKT) cells and both enable DNA binding. One of these genes encodes ... | |
medium_hidden_intermediate_05976 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are upregulated by the virus and participate in the process 'Amino acids regulate mTORC1'. One of these genes exhibits a log2 fold change of approximately 1.31 and an adjusted p-value of approximately 0.048. Which protein is encoded by this spe... | Cytosolic arginine sensor for mTORC1 subunit 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05976","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are upregulated by the virus and participate in ... | |
medium_hidden_intermediate_05977 | Human betaherpesvirus 5 is known to downregulate a specific gene that participates in signal transduction. Experimental data for this gene in foreskin fibroblast cell lines (study GSE111036) reports a log2 fold change of -1.051 and an adjusted p-value of 0.04954. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05977","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate a specific gene that participates in signal transduction. Experimental data... | |
medium_hidden_intermediate_05978 | In a study of cardiomyocyte cell lines, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Signaling by Interleukins. Evidence for this specific gene reports a log2 fold change of approximately 1.45 and an adjusted p-value of 0.0258. Which protein is encoded by this gene? | Pro-interleukin-16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05978","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and p... | |
medium_hidden_intermediate_05979 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its product is located in the lysosomal membrane. Evidence for this gene reports a log2 fold change of approximately 1.069 and an adjusted p-value of 0.04315. Which protein is encoded by this gene? | AP-5 complex subunit beta-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05979","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its produc... | |
medium_hidden_intermediate_05980 | Two genes are upregulated by Vaccinia virus and interact with HDAC1. One of these genes shows a log2 fold change of 4.404 and an adjusted p-value of 0.002548 in a specific study. Which cell type is enriched for this specific gene? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05980","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with HDAC1. One of these genes shows a log2 fold change of 4.404 an... | |
medium_hidden_intermediate_05981 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to EIF2B2 via an 'interacts with' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.526 and an adjusted p-value of 0.02674. Which protein... | Long-chain fatty acid transport protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05981","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_05982 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to hepatocellular carcinoma via an association relationship. One of these genes has reported expression data showing a log2 fold change of approximately -1.31 and an adjusted p-value of 0.0... | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05982","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationsh... | |
medium_hidden_intermediate_05985 | Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to Plasmacytoid dendritic cells (pDCs) via an 'enriched in' relationship. One of these genes has a reported log2 fold change of -1.490 and an adjusted p-value of 0.0129 in cervical adenocarcinoma cell lines (study GSE122967). Whic... | tRNA-uridine aminocarboxypropyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05985","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to Plasmacytoid dendritic cells (p... | |
medium_hidden_intermediate_05986 | Zika virus upregulates a gene that is enriched in basophils. Evidence for this gene in glioblastoma multiforme cancer stem cells reports a log2 fold change of approximately 1.88 and an adjusted p-value of 0.0102. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05986","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is enriched in basophils. Evidence for this gene in glioblastoma multiforme cancer stem c... | |
medium_hidden_intermediate_05987 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A upregulates a gene that enables potassium channel regulator activity. One such gene exhibits a log2 fold change of 1.712 and an adjusted p-value of 0.03691. Which biological process is this specific gene involved in? | intracellular signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05987","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A upregulates a gene that enables potassium channel regulator ... | |
medium_hidden_intermediate_05988 | Human alphaherpesvirus 1 is reported to downregulate a gene that is associated with polyarticular arthritis. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibited a log2 fold change of approximately -1.495 and an adjusted p-value of 0.00526. Which protein is encoded by this specific gene? | Protein LBH | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05988","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is reported to downregulate a gene that is associated with polyarticular arthritis. In a study of m... | |
medium_hidden_intermediate_05989 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to colorectal carcinoma via a biomarker relationship. One of these genes is associated with a log2 fold change of 2.546 and an adjusted p-value of 0.01108. Which protein is encoded by this specific gene? | Phosphatidylinositol-3-phosphate phosphatase MTMR7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05989","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to colore... | |
medium_hidden_intermediate_05990 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to TRAPPC6B. Evidence for this gene reports a log2 fold change of 1.427 and an adjusted p-value of 0.007892. Which protein is encoded by this gene? | Trafficking protein particle complex subunit 2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05990","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to TRAPPC6B. Evidence for this gene... | |
medium_hidden_intermediate_05991 | In a study of cervical adenocarcinoma cell lines (GSE11238), two genes are upregulated by Vaccinia virus and bind to TMEM258. One of these genes exhibits a log2 fold change of 2.589 and an adjusted p-value of 2.32e-13. Which protein is encoded by this specific gene? | Oligosaccharyltransferase complex subunit OSTC | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05991","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), two genes are upregulated by Vaccinia virus and bind to TMEM258... | |
medium_hidden_intermediate_05992 | Zika virus downregulates a gene that is located in the mitochondrial inner membrane. Experimental data from glioma stem cells (study GSE114907) indicates that one such gene has a log2 fold change of approximately -2.53 and an adjusted p-value of 0.0077. Which protein interacts with this specific gene product? | CLPP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05992","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the mitochondrial inner membrane. Experimental data from glioma stem cell... | |
medium_hidden_intermediate_05993 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which subsequently binds to TAF9. This gene exhibits a log2 fold change of approximately 1.064 and an adjusted p-value of 0.002388. What molecular function is enabled by this gene? | transcription coactivator activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05993","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_05994 | A protein is expressed in Natural killer T cells and binds to PRKAR2A. Experimental evidence indicates that this protein, referred to as a specific A-kinase anchoring protein, coimmunoprecipitates with RIIalpha (encoded by PRKAR2A) from HeLa cells arrested in mitosis, demonstrating a physical association during this ce... | A-kinase anchor protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05994","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein is expressed in Natural killer T cells and binds to PRKAR2A. Experimental evidence indicates that this protein, re... | |
medium_hidden_intermediate_05995 | Human alphaherpesvirus 1 upregulates a specific gene product that participates in the process where HDACs deacetylate histones. In a study of monocytic leukemia cell lines (GSE114966), this entity was reported to have a log2 fold change of 2.124 and an adjusted p-value of 0.009046. Which protein is encoded by this gene... | Histone H2B type 1-C/E/F/G/I | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05995","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a specific gene product that participates in the process where HDACs deacetylate histon... | |
medium_hidden_intermediate_05999 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its product enables retinoid binding. Evidence for this gene reports a log2 fold change of -2.944 and an adjusted p-value of 0.0005284. Which protein is encoded by this gene? | Cellular retinoic acid-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05999","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its prod... | |
medium_hidden_intermediate_06000 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that participates in the conjugation of benzoate with glycine. One such gene exhibits a log2 fold change of 2.575 and an adjusted p-value of 0.003988. Which protein is encoded by this specific gene? | Glycine N-acyltransferase-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06000","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that participates in the conj... | |
medium_hidden_intermediate_06002 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Evidence for this specific gene shows a log2 fold change of -1.517 and an adjusted p-value of 0.03482. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06002","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in the metabolism of carbohydrates and carbohyd... | |
medium_hidden_intermediate_06005 | Pegivirus C is reported to downregulate a specific gene that is involved in the regulation of the apoptotic process. Transcriptomic data for this gene indicates a log2 fold change of approximately -1.40 and an adjusted p-value of 0.0046. In which cell type is this gene enriched? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06005","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that is involved in the regulation of the apoptotic process. Transcr... | |
medium_hidden_intermediate_06006 | BMI1 binds to a protein that participates in Cellular Senescence. Evidence indicates that HPH1 and a second protein coimmunoprecipitate and cofractionate with each other and with BMI1. Which protein is encoded by the gene corresponding to this interacting partner? | Polyhomeotic-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06006","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"BMI1 binds to a protein that participates in Cellular Senescence. Evidence indicates that HPH1 and a second protein coimmuno... | |
medium_hidden_intermediate_06007 | Two genes are structurally linked to FADD via a 'binds' interaction and subsequently linked to the molecular function 'protein binding' via an 'enables' relationship. One of these genes is supported by evidence stating that its encoded protein interacts with both caspase-8 and FADD in vivo and in vitro. Which protein i... | FAS-associated factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06007","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to FADD via a 'binds' interaction and subsequently linked to the molecular function 'prote... | |
medium_hidden_intermediate_06008 | Zika virus downregulates a specific gene, which is subsequently linked to lung carcinoma through genomic alterations. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -3.48 and an adjusted p-value of 0.0204. Which cellular component is this gene located ... | Cul4-RING E3 ubiquitin ligase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06008","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which is subsequently linked to lung carcinoma through genomic alterations. Experi... | |
medium_hidden_intermediate_06010 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its product interacts with GEMIN4. Experimental data for this gene reports a log2 fold change of 1.347 and an adjusted p-value of 6.216e-08. Which protein is encoded by this gene? | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06010","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its product interacts with GEMIN4... | |
medium_hidden_intermediate_06012 | Hepacivirus C upregulates a gene that participates in cellular responses to stress. Evidence for one such gene reports a log2 fold change of 1.067 and an adjusted p-value of 0.0311. Which protein is encoded by that gene? | Polycomb protein SCMH1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06012","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in cellular responses to stress. Evidence for one such gene reports a log... | |
medium_hidden_intermediate_06013 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the glutamine metabolic process. One of these genes exhibits a log2 fold change of approximately 1.81 and an adjusted p-value of approximately 0.0147 in bronchial epithelial cells. What molecular function is enabled b... | omega-amidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06013","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the glutamine metabol... | |
medium_hidden_intermediate_06014 | Hepacivirus C is reported to downregulate a gene that participates in lipid metabolism. Evidence for this gene shows a log2 fold change of -2.147 and an adjusted p-value of 0.0007022. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06014","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that participates in lipid metabolism. Evidence for this gene shows a log2 ... | |
medium_hidden_intermediate_06015 | Zika virus downregulates a gene that participates in the metabolism of steroids. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.314 and an adjusted p-value of 0.04405. Which disease is associated with genomic alterations in this specific gene? | polycystic ovary syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06015","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the metabolism of steroids. Evidence for this gene in glioma stem cells... | |
medium_hidden_intermediate_06016 | Zika virus downregulates a gene that participates in deubiquitination. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.63 and an adjusted p-value of approximately 0.015. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06016","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in deubiquitination. Evidence for this gene in glioma stem cells (study GS... | |
medium_hidden_intermediate_06017 | Pegivirus C is reported to downregulate a specific gene, which in turn encodes a protein that binds to UTP18. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) show a log2 fold change of -1.068 and an adjusted p-value of 0.03004. What is the name of the protein encoded by this... | Nucleolar protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06017","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn encodes a protein that binds to UTP18. Experimental d... | |
medium_hidden_intermediate_06018 | Zika virus downregulates a specific gene that is involved in the DNA damage response. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -2.64 and an adjusted p-value of 0.0029. Which disease is associated with this gene? | intellectual developmental disorder, autosomal recessive 71 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06018","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the DNA damage response. Experimental data from glioma stem cel... | |
medium_hidden_intermediate_06019 | Zika virus downregulates a specific gene, which in turn participates in the process where RAB GEFs exchange GTP for GDP on RABs. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.74 and an adjusted p-value of 0.017. Which protein is encoded by this gen... | Ras and Rab interactor 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06019","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn participates in the process where RAB GEFs exchange GTP for GDP on R... | |
medium_hidden_intermediate_06020 | Two distinct proteins are known to bind to Syntaxin 6 (STX6) and subsequently interact with TSSC1. Biochemical evidence indicates that one of these proteins, along with Ang2, Vps53, and itself, forms an obligatory 1:1:1:1 complex that strongly interacts with the regulatory Habc domain of the TGN SNARE, Syntaxin 6. Whic... | Vacuolar protein sorting-associated protein 54 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06020","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct proteins are known to bind to Syntaxin 6 (STX6) and subsequently interact with TSSC1. Biochemical evidence indi... | |
medium_hidden_intermediate_06022 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of angiogenesis. Evidence for one such gene reports a log2 fold change of 4.466 and an adjusted p-value of 0.03446. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06022","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of angi... | |
medium_hidden_intermediate_06023 | Human immunodeficiency virus 1 downregulates a gene that is located in the mitochondrial inner membrane. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately -1.90 and an adjusted p-value of approximately 0.021. Which biological process is this gene involved in? | protein maturation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06023","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the mitochondrial inner membrane. Evidence for this g... | |
medium_hidden_intermediate_06025 | Vaccinia virus upregulates a gene that participates in immunoregulatory interactions between a lymphoid and a non-lymphoid cell. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibits a log2 fold change of approximately 1.465 and an adjusted p-value of 0.01201. Which biological process is t... | T cell activation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06025","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that participates in immunoregulatory interactions between a lymphoid and a non-lymphoid c... | |
medium_hidden_intermediate_06026 | A gene is upregulated by Hepacivirus C and participates in Developmental Cell Lineages of the Exocrine Pancreas. Evidence for this gene reports a log2 fold change of approximately 4.20 and an adjusted p-value of 0.03528. Which disease is associated with this gene as a biomarker? | hypertensive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06026","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and participates in Developmental Cell Lineages of the Exocrine Pancreas. Evidence fo... | |
medium_hidden_intermediate_06027 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the process of Binding and Uptake of Ligands by Scavenger Receptors. One of these genes exhibits a log2 fold change of 1.638 and an adjusted p-value of 3.991e-07 in a specific study. Which protein is encoded by the gen... | Haptoglobin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06027","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the process of Binding... | |
medium_hidden_intermediate_06028 | Pegivirus C downregulates a gene that participates in the metabolism of amino acids and derivatives. Evidence for this gene in peripheral blood mononuclear cells (study GSE131504) reports a log2 fold change of -1.572 and an adjusted p-value of 0.0001203. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06028","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in the metabolism of amino acids and derivatives. Evidence for this gene ... | |
medium_hidden_intermediate_06030 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that subsequently binds to HLA-DRB4. Experimental data for one such intermediate gene reports a log2 fold change of 2.166 and an adjusted p-value of 0.0116. Which protein is encoded by this specific gene? | AP-1 complex subunit mu-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06030","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that subsequently binds to HLA-DRB4. Experimental d... | |
medium_hidden_intermediate_06032 | Two genes are upregulated by Human immunodeficiency virus 1 and involved in 3'-UTR-mediated mRNA stabilization. One of these genes shows a log2 fold change of approximately 2.025 and an adjusted p-value of 0.03089 in a specific cell type. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06032","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and involved in 3'-UTR-mediated mRNA stabilization. One of these... | |
medium_hidden_intermediate_06034 | RAMP2 is involved in two distinct biological processes that both result in the formation of blood vessels. One of these processes is characterized by the emergence of new vessels from the proliferation of pre-existing blood vessels. Which biological process is this? | anatomical structure formation involved in morphogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06034","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"RAMP2 is involved in two distinct biological processes that both result in the formation of blood vessels. One of these proc... | |
medium_hidden_intermediate_06035 | Measles morbillivirus downregulates a gene that participates in glycerophospholipid biosynthesis. Evidence for this specific gene reports a log2 fold change of -1.614 and an adjusted p-value of 0.003353. Which molecular function is enabled by this gene? | glycerophospholipid phospholipase A1 activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06035","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that participates in glycerophospholipid biosynthesis. Evidence for this specific... | |
medium_hidden_intermediate_06036 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in protein K48-linked ubiquitination. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.955 and an adjusted p-value of 0.04386. Which protein is encoded by this gene? | Cell division cycle protein 23 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06036","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in protein K48-linked ubiquitination... | |
medium_hidden_intermediate_06038 | Pegivirus C is reported to downregulate multiple genes that are involved in the positive regulation of the apoptotic process. One such gene exhibits a log2 fold change of -1.696 and an adjusted p-value of 9.429e-05 in peripheral blood mononuclear cells. Which cellular component is this specific gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06038","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate multiple genes that are involved in the positive regulation of the apoptotic process... | |
medium_hidden_intermediate_06041 | Hepacivirus C infection is associated with the upregulation of certain genes whose products are located in the extracellular space. One such gene exhibits a log2 fold change of 2.143 and an adjusted p-value of 0.006446 in liver cells. Which protein is encoded by this specific gene? | Neutrophil defensin 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06041","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C infection is associated with the upregulation of certain genes whose products are located in the extracellular... | |
medium_hidden_intermediate_06043 | A gene is downregulated by Vaccinia virus and participates in the metabolism of amino acids and derivatives. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -1.519 and an adjusted p-value of 0.01844. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06043","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and participates in the metabolism of amino acids and derivatives. Experimental da... | |
medium_hidden_intermediate_06044 | A specific ubiquitin conjugating enzyme, which is anchored in the ER membrane and partners with RNF26, serves as a marker for a progenitor cell type and enables protein binding. Which cell type is enriched in this enzyme? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06044","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific ubiquitin conjugating enzyme, which is anchored in the ER membrane and partners with RNF26, serves as a marker fo... | |
medium_hidden_intermediate_06045 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of specific genes involved in the immune system. One such gene exhibits a log2 fold change of -2.107 and an adjusted p-value of 0.001811. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06045","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of specific gen... | |
medium_hidden_intermediate_06048 | Pegivirus C is reported to downregulate a specific gene, which in turn encodes a protein that binds to SAP30L. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.34 and an adjusted p-value of approximately 0.0052. What is the name of... | Bromodomain adjacent to zinc finger domain protein 2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06048","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn encodes a protein that binds to SAP30L. Experimental ... | |
medium_hidden_intermediate_06050 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to UNC93B1 via an 'interacts with' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.065 and an adjusted p-value of 0.001785. Which prote... | Sperm-associated antigen 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06050","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_06051 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable oxidoreductase activity. One of these genes exhibits a log2 fold change of 1.454 and an adjusted p-value of 0.01897 in a specific study. Which cellular component is the location of this specific gene? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06051","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable oxidoreductase activity. ... | |
medium_hidden_intermediate_06056 | A gene is identified as a marker for monocytes and is involved in the positive regulation of epithelial-to-mesenchymal transition. Evidence indicates that overexpression of this gene in HK-2 cells potentiates EMT-like processes through the ERK1/2 signaling pathway. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06056","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is identified as a marker for monocytes and is involved in the positive regulation of epithelial-to-mesenchymal trans... | |
medium_hidden_intermediate_06058 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A was found to upregulate a gene that enables sequence-specific double-stranded DNA binding. This specific gene exhibited a log2 fold change of 2.291 and an adjusted p-value of 0.04068. Which protein interacts with this gene product? | PKN1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06058","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A was found to upregulate a gene that enables sequence-specifi... | |
medium_hidden_intermediate_06061 | Hepacivirus C upregulates a gene that enables protein kinase binding. Experimental data for this gene in hepatocytes shows a log2 fold change of approximately 1.08 and an adjusted p-value of 0.0003355. Which protein does this gene interact with? | MRM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06061","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables protein kinase binding. Experimental data for this gene in hepatocytes shows a... | |
medium_hidden_intermediate_06064 | A gene serves as a marker for germ cells and is enriched in non-classical monocytes. Evidence for one such gene reports a mean expression of 108.47 TPM, a z-score of 1.69, and a fold enrichment of 2.61. Which disease is associated with this gene as a biomarker? | bipolar disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06064","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for germ cells and is enriched in non-classical monocytes. Evidence for one such gene reports a me... | |
medium_hidden_intermediate_06065 | Two genes are identified as markers of endothelial cells and are associated with lung carcinoma. One of these genes is the target of an antibody that inhibits VEGF-C induction in AGZY83-a cells, as described in studies involving media from Anip973, AGZY83-a, and A549 cells. Which protein interacts with this specific ge... | PICK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06065","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers of endothelial cells and are associated with lung carcinoma. One of these genes is the t... | |
medium_hidden_intermediate_06068 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and its protein product is located in the centrosome. Evidence for this gene reports a log2 fold change of 1.165 and an adjusted p-value of 4.483e-09. Which protein is encoded by this gene... | Nuclear protein MDM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06068","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_06070 | Human betaherpesvirus 5 is reported to downregulate a gene that subsequently binds to ITGB1. In a study involving foreskin fibroblast cell lines, one such gene exhibited a log2 fold change of approximately -4.185 and an adjusted p-value of 0.009364. Which protein is encoded by this specific gene? | Collagen alpha-1(VIII) chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06070","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that subsequently binds to ITGB1. In a study involving foreskin f... | |
medium_hidden_intermediate_06073 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and is involved in the positive regulation of cell population proliferation. Experimental data for this gene reports a log2 fold change of -1.423 and an adjusted p-value of 0.02928. Which protein is encoded by this gene? | Aldo-keto reductase family 1 member C3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06073","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and is involved in the positive reg... | |
medium_hidden_intermediate_06076 | A gene is downregulated by Primate bocaparvovirus 1 and is enriched in naive CD4+ T cells. Experimental data for this gene in tracheobronchial epithelial cells (study GSE102392) reports a log2 fold change of approximately -1.448 and an adjusted p-value of 0.008572. Which protein is encoded by this gene? | Adenylate kinase isoenzyme 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06076","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is enriched in naive CD4+ T cells. Experimental data for this gene i... | |
medium_hidden_intermediate_06077 | A gene serves as a marker for microglial cells and is enriched in non-classical monocytes. Evidence for this gene includes a mean expression of 25.43 TPM, a z-score of 2.14, and a fold enrichment of 3.97. Which protein does this gene product interact with? | NHERF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06077","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for microglial cells and is enriched in non-classical monocytes. Evidence for this gene includes a... |
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