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medium_hidden_intermediate_06078 | Zika virus infection leads to the downregulation of certain genes that enable DNA binding. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.377 and an adjusted p-value of 0.01209. Which protein is encoded by this specific gene? | RAD51-associated protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06078","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of certain genes that enable DNA binding. In a study of glioma stem cells (... | |
medium_hidden_intermediate_06079 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both enable magnesium ion binding. One of these genes exhibits a log2 fold change of -1.415 and an adjusted p-value of 1.135e-07 in a specific study. Which disease is associated with this specific gene as a biomarker? | amyloidosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06079","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both enable magnesium ion binding. ... | |
medium_hidden_intermediate_06080 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and participates in cell junction organization. Evidence for this gene reports a log2 fold change of -2.138 and an adjusted p-value of 0.01278. Which protein is encoded by this gene? | Disintegrin and metalloproteinase domain-containing protein 33 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06080","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and particip... | |
medium_hidden_intermediate_06081 | Hepacivirus C is reported to downregulate a specific gene that participates in nucleotide metabolism. Experimental data for this gene show a log2 fold change of approximately -1.082 and an adjusted p-value of 0.005313. Which disease is associated with this gene? | plasma cell myeloma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06081","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene that participates in nucleotide metabolism. Experimental data for ... | |
medium_hidden_intermediate_06084 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its product enables protein kinase binding. This gene exhibits a log2 fold change of approximately 4.17 and an adjusted p-value of approximately 0.0087. Which protein is encoded by this gene? | Speedy protein A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06084","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its produc... | |
medium_hidden_intermediate_06085 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with NUFIP2. One of these genes exhibits a log2 fold change of approximately -1.25 and an adjusted p-value of 0.012 in lung tissue. Which biological process is this specific gene involved in? | maintenance of protein location in cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06085","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with NUFIP2. One of these ... | |
medium_hidden_intermediate_06086 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes whose products are located in the extracellular region. One such gene exhibited a log2 fold change of 5.082 and an adjusted p-value of 0.0002122. Which protein is encoded by this specific gene? | Galectin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06086","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_06090 | Two genes are structurally linked from Enterovirus A (via upregulation) to Signaling by WNT (via participation). One of these genes was reported in a study (GSE103308) on rhabdomyosarcoma cells with a log2 fold change of approximately 3.58 and an adjusted p-value of 0.003058. Which disease is associated with this speci... | Crohn disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06090","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Enterovirus A (via upregulation) to Signaling by WNT (via participation). One of thes... | |
medium_hidden_intermediate_06094 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of certain genes that are enriched in natural killer cells. One such gene exhibits a log2 fold change of approximately -1.305 and an adjusted p-value of approximately 0.009975. Which protein is encoded by t... | Pentatricopeptide repeat-containing protein 2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06094","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of certain... | |
medium_hidden_intermediate_06096 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Organelle biogenesis and maintenance. Evidence for this gene reports a log2 fold change of 1.364 and an adjusted p-value of 0.001258. Which disease is associated with this gene as a biomarker? | polydactyly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06096","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Organelle biogenesis and ... | |
medium_hidden_intermediate_06098 | In a study of Human alphaherpesvirus 1 infection in a monocytic leukemia cell line, a specific gene is upregulated by the virus and participates in Signaling by WNT. This gene exhibits a log2 fold change of 1.170 and an adjusted p-value of 0.02112. Which protein is encoded by this gene? | Transmembrane emp24 domain-containing protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06098","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Human alphaherpesvirus 1 infection in a monocytic leukemia cell line, a specific gene is upregulated by the vi... | |
medium_hidden_intermediate_06100 | Human immunodeficiency virus 1 downregulates a gene that participates in transport to the Golgi and subsequent modification. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.042 and an adjusted p-value of 0.008318. Which cellular component is this gene located in? | endoplasmic reticulum membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06100","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in transport to the Golgi and subsequent modification.... | |
medium_hidden_intermediate_06101 | Measles morbillivirus is known to upregulate certain genes that enable metalloendopeptidase activity. One such gene exhibits a log2 fold change of 1.374 and an adjusted p-value of 0.0004613 in pleural mesothelioma cells. Which disease is associated with this specific gene as a biomarker? | Parkinson disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06101","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus is known to upregulate certain genes that enable metalloendopeptidase activity. One such gene exhibits... | |
medium_hidden_intermediate_06102 | MCFD2 interacts with a protein that participates in endoplasmic reticulum to Golgi vesicle-mediated transport. Evidence indicates that specific inactivation of this protein by VirA/EspG disrupts ER-to-Golgi trafficking. Which protein is encoded by the gene corresponding to this entity? | Ras-related protein Rab-1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06102","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"MCFD2 interacts with a protein that participates in endoplasmic reticulum to Golgi vesicle-mediated transport. Evidence indi... | |
medium_hidden_intermediate_06103 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene that participates in signal transduction. This gene exhibits a log2 fold change of -1.183 and an adjusted p-value of 0.01358. Which disease is associated with genomic alterations in this ... | major affective disorder 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06103","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_06104 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of specific entities located in the late endosome membrane. One such entity exhibits a log2 fold change of 2.418 and an adjusted p-value of 1.458e-08. Which protein is encoded by the gene corresponding to this spe... | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06104","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of specific entit... | |
medium_hidden_intermediate_06106 | A gene is downregulated by Cardiovirus A and enriched in eosinophils. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -2.616 and an adjusted p-value of 0.01929. Which protein is encoded by this gene? | Structure-specific endonuclease subunit SLX1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06106","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and enriched in eosinophils. Experimental data for this gene in a cervical adenocar... | |
medium_hidden_intermediate_06107 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its expression is enriched in memory B cells. Evidence for this gene reports a log2 fold change of approximately 1.38 and an adjusted p-value of approximately 2.13e-06. Which protein is encoded by this gene? | Pleckstrin homology domain-containing family F member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06107","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its expression is enriched in mem... | |
medium_hidden_intermediate_06108 | Pegivirus C downregulates a gene that subsequently interacts with LAMP1. In a study of peripheral blood mononuclear cells (GSE131504), one such intermediate gene exhibits a log2 fold change of -2.221 and an adjusted p-value of 0.04971. Which protein is encoded by this specific gene? | Copine-8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06108","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that subsequently interacts with LAMP1. In a study of peripheral blood mononuclear cells (G... | |
medium_hidden_intermediate_06109 | Cardiovirus A upregulates a gene that is involved in the chemokine-mediated signaling pathway. Experimental data from a cervical adenocarcinoma cell line study (GSE122967) indicates that this specific gene has a log2 fold change of 2.752 and an adjusted p-value of 0.04051. Which protein is encoded by this gene? | C-X-C motif chemokine 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06109","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that is involved in the chemokine-mediated signaling pathway. Experimental data from a cerv... | |
medium_hidden_intermediate_06110 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SFXN1. One of these genes exhibits a log2 fold change of 1.611 and an adjusted p-value of 0.002107 in a specific study. Which biological process is this gene involved in? | antiviral innate immune response | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06110","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SFXN1. One of these gen... | |
medium_hidden_intermediate_06111 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Heparan sulfate/heparin (HS-GAG) metabolism. One of these genes exhibits a log2 fold change of 1.068 and an adjusted p-value of 0.0007106. Which biological process is this specific gene involved in? | heparan sulfate proteoglycan biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06111","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Heparan sulfate/hepari... | |
medium_hidden_intermediate_06112 | Enterovirus A is reported to downregulate a gene that participates in the Generic Transcription Pathway. In a study involving rhabdomyosarcoma cells, one such gene exhibited a log2 fold change of approximately -1.26 and an adjusted p-value of approximately 0.0035. Which protein is encoded by this specific gene? | Zinc finger protein 710 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06112","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a gene that participates in the Generic Transcription Pathway. In a study involvin... | |
medium_hidden_intermediate_06113 | Bone neoplasms can be localized to various synovial limb joints. One such joint connects the thigh to the leg, comprising articulations between the femur and tibia as well as the femur and patella. It is described as the largest and most complex joint in the human body, functioning as a mobile trocho-ginglymus that all... | knee | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06113","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Bone neoplasms can be localized to various synovial limb joints. One such joint connects the thigh to the leg, comprising ar... | |
medium_hidden_intermediate_06114 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with CYTH2. One such gene exhibits a log2 fold change of -1.194 and an adjusted p-value of 4.236e-05 in a specific study. Which protein is encoded by this gene? | Innate immunity activator protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06114","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with CYTH2. One such gene exhibits... | |
medium_hidden_intermediate_06115 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to arthritic joint disease via an association relationship. One of these genes was reported in a study using a pancreatic cell line, with a log2 fold change of approximately 1.236 and an adjusted p-value o... | Cytochrome P450 1A1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06115","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to arthri... | |
medium_hidden_intermediate_06116 | Two genes are upregulated by Vaccinia virus and participate in chromatin organization. One of these genes shows a log2 fold change of 1.120 and an adjusted p-value of 9.779e-07 in a cervical adenocarcinoma cell line study. Which disease is associated with this specific gene? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06116","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in chromatin organization. One of these genes shows a log2 fold ... | |
medium_hidden_intermediate_06118 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of a specific gene, which subsequently interacts with AIFM1. This gene exhibits a log2 fold change of approximately 2.21 and an adjusted p-value of 5.79e-08. In which cellular component is this gene product locate... | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06118","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of a specific gen... | |
medium_hidden_intermediate_06119 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to colorectal carcinoma via genomic alterations. One of these genes exhibits a log2 fold change of 2.530 and an adjusted p-value of 1.927e-16 in stomach cells. Which cellular component is associated with this specific gen... | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06119","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to colorectal carcinoma v... | |
medium_hidden_intermediate_06121 | Zika virus downregulates a specific transcription factor that enables transcription cis-regulatory region binding. In a study of glioma stem cells (GSE114907), this transcription factor exhibited a log2 fold change of -1.291 and an adjusted p-value of 0.02775. Which protein does this transcription factor bind to? | TLE2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06121","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific transcription factor that enables transcription cis-regulatory region binding. In a stud... | |
medium_hidden_intermediate_06122 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which subsequently binds to NCBP1. This intermediate gene exhibits a log2 fold change of -2.191 and an adjusted p-value of 0.04471. Which protein does this intermediate gene interact wit... | LMNA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06122","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_06123 | Two genes are linked to Zika virus via downregulation and to adenoviridae infectious disease via association. One of these genes exhibits a log2 fold change of -1.172 and an adjusted p-value of 0.02441 in glioma stem cells. Which cell type is enriched for this specific gene? | intermediate monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06123","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Zika virus via downregulation and to adenoviridae infectious disease via association. One of these g... | |
medium_hidden_intermediate_06124 | Zika virus downregulates a specific gene, which in turn interacts with PLK1. Experimental data for this intermediate gene reports a log2 fold change of approximately -2.11 and an adjusted p-value of 0.0092. Which disease is associated with this intermediate gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06124","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with PLK1. Experimental data for this intermediate gene re... | |
medium_hidden_intermediate_06125 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to prostate cancer via an association relationship. One of these genes exhibits a log2 fold change of -2.787 and an adjusted p-value of 0.02313 in a specific study context. Which cell type is enriched for that spec... | intermediate monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06125","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to prostate cancer... | |
medium_hidden_intermediate_06126 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes involved in extracellular matrix organization. One such gene exhibits a log2 fold change of approximately -2.615 and an adjusted p-value of 0.0002759. Which protein is encoded by this specific gene? | Serine protease HTRA1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06126","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes invol... | |
medium_hidden_intermediate_06128 | Zika virus upregulates a gene that participates in the Immune System. Evidence for this gene reports a log2 fold change of 1.401 and an adjusted p-value of 0.01461. Which disease is associated with this gene as a biomarker? | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06128","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in the Immune System. Evidence for this gene reports a log2 fold change of 1... | |
medium_hidden_intermediate_06130 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables bHLH transcription factor binding. One such gene exhibits a log2 fold change of approximately 3.398 and an adjusted p-value of 0.003861. Which protein is encoded by this specific gene? | Transcription factor 21 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06130","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables bHLH transcription fac... | |
medium_hidden_intermediate_06131 | Pegivirus C is reported to downregulate a specific gene that is located in the nuclear membrane. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.789 and an adjusted p-value of 0.007725. Which disease is associated with this gene? | B-cell chronic lymphocytic leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06131","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that is located in the nuclear membrane. In a study of peripheral bl... | |
medium_hidden_intermediate_06132 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in kidney development. In a specific study involving foreskin fibroblast cell lines, this gene exhibited a log2 fold change of -1.136 and an adjusted p-value of 0.003039. Which protein is encoded by this gene? | Forkhead box protein C2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06132","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in kidney development. In a specific study invo... | |
medium_hidden_intermediate_06133 | Cardiovirus A downregulates a specific gene, which in turn interacts with EED. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.273 and an adjusted p-value of 0.0119. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06133","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a specific gene, which in turn interacts with EED. Experimental data for this gene in a cervical... | |
medium_hidden_intermediate_06135 | Human immunodeficiency virus 1 downregulates a gene that is involved in the regulation of actin cytoskeleton organization. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.794 and an adjusted p-value of 0.006248. Which protein is encoded by this gene? | Coronin-1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06135","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the regulation of actin cytoskeleton organization. I... | |
medium_hidden_intermediate_06136 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate a specific gene that participates in Oncogenic MAPK signaling. This gene exhibited a log2 fold change of 2.259 and an adjusted p-value of 2.188e-06. Which protein is encoded by this gene? | Lysine-specific demethylase 7A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06136","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_06137 | Hepacivirus C upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Evidence for one such gene reports a log2 fold change of 1.086 and an adjusted p-value of 0.002711. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06137","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Evidence... | |
medium_hidden_intermediate_06140 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with OFD1. One of these genes exhibits a log2 fold change of 2.495 and an adjusted p-value of 0.01708 in a specific study. Which protein is encoded by this gene? | Protein FAM184A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06140","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with OFD1. One of these gene... | |
medium_hidden_intermediate_06141 | Human betaherpesvirus 5 is reported to upregulate a gene that is associated with uterine cancer. In a study of foreskin fibroblast cell lines (GSE132081), one such gene exhibited a log2 fold change of 3.664 and an adjusted p-value of 0.02313. Which protein is encoded by this specific gene? | Serpin B4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06141","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is associated with uterine cancer. In a study of foreskin fibr... | |
medium_hidden_intermediate_06142 | In a study of umbilical vein endothelial cells (GSE119608), a gene is downregulated by Human gammaherpesvirus 8 and is involved in the negative regulation of cell migration. Evidence for this gene reports a log2 fold change of approximately -3.21 and an adjusted p-value of 0.0155. Which protein is encoded by this gene? | Low-density lipoprotein receptor class A domain-containing protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06142","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of umbilical vein endothelial cells (GSE119608), a gene is downregulated by Human gammaherpesvirus 8 and is invol... | |
medium_hidden_intermediate_06144 | Hepacivirus C is reported to downregulate a gene that is involved in signal transduction. Evidence for this specific gene in a study (GSE119117) indicates a log2 fold change of approximately -1.374 and an adjusted p-value of 0.01288. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06144","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is involved in signal transduction. Evidence for this specific gene in... | |
medium_hidden_intermediate_06146 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein serine/threonine kinase activity. Evidence for this gene reports a log2 fold change of 1.656 and an adjusted p-value of 0.009456. Which disease is associated with this gene as a biomarker? | systemic lupus erythematosus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06146","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein serine/threonine kinase a... | |
medium_hidden_intermediate_06148 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable DNA-binding transcription repressor activity, RNA polymerase II-specific. One of these genes exhibits a log2 fold change of 3.576 and an adjusted p-value of 0.0004939 in lung tissue data from study GSE148697. Which diseas... | Endometrial carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06148","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable DNA-binding transcription... | |
medium_hidden_intermediate_06154 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Organelle biogenesis and maintenance. Experimental data for this gene reports a log2 fold change of -1.832 and an adjusted p-value of 0.03375. Which protein is encoded by this gene? | GA-binding protein subunit beta-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06154","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Organelle biogenesis an... | |
medium_hidden_intermediate_06155 | Human immunodeficiency virus 1 upregulates a gene that enables receptor ligand activity. In a study of macrophages (GSE108897), one such gene showed a log2 fold change of 2.302 and an adjusted p-value of 2.815e-06. Which protein is encoded by this gene? | Natural cytotoxicity triggering receptor 3 ligand 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06155","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables receptor ligand activity. In a study of macrophages (GSE10889... | |
medium_hidden_intermediate_06156 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific histone variant that participates in RNA Polymerase I Promoter Opening. This entity exhibits a log2 fold change of approximately 2.15 and an adjusted p-value of 0.0022. Which protein is encoded by this upregulated gene? | Histone H3.1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06156","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific histone variant that part... | |
medium_hidden_intermediate_06157 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that enables ubiquitin protein ligase activity. This gene exhibited a log2 fold change of 2.147 and an adjusted p-value of 0.008088. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06157","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that enabl... | |
medium_hidden_intermediate_06160 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with NFIB. One of these genes shows a log2 fold change of approximately 1.30 and an adjusted p-value of approximately 0.0076 in a specific study. In which cell type is this gene enriched? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06160","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with NFIB. One of these gene... | |
medium_hidden_intermediate_06161 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and interacts with DNAJA1. This specific gene exhibits a log2 fold change of -1.891 and an adjusted p-value of 0.02686. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06161","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and inte... | |
medium_hidden_intermediate_06164 | Human mastadenovirus C downregulates a gene that enables protein binding. In a study of lung fibroblast cell lines (GSE120891), one such gene exhibits a log2 fold change of -2.314 and an adjusted p-value of 0.03888. Which protein is encoded by this gene? | Zinc finger protein 418 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06164","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human mastadenovirus C downregulates a gene that enables protein binding. In a study of lung fibroblast cell lines (GSE12089... | |
medium_hidden_intermediate_06166 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to CCNF via an interaction relationship. One of these genes is reported in a study (GSE157852) involving choroid plexus epithelium cells, with a log2 fold change of approximately 1.575 and an ... | bipolar disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06166","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_06167 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for depressive disorder. Evidence for this gene reports a log2 fold change of 7.637 and an adjusted p-value of 0.03342. Which disease is connected to this gene through genomic alterations? | duplication/inversion 15q11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06167","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for depressive diso... | |
medium_hidden_intermediate_06168 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. This gene exhibits a log2 fold change of 1.209 and an adjusted p-value of 0.0004572. In which cell type is this ge... | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06168","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_06171 | Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of viral transcription. Evidence for one such gene reports a log2 fold change of 1.046 and an adjusted p-value of 0.01017. Which protein is encoded by that gene? | E3 ubiquitin-protein ligase TRIM62 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06171","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of viral transcription. Eviden... | |
medium_hidden_intermediate_06173 | Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that is involved in the regulation of the glucosylceramide biosynthetic process. Evidence for one such gene indicates a log2 fold change of -1.046 and an adjusted p-value of 1.911e-08. Which protein is encoded by this gene? | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06173","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that is involved in the regulation ... | |
medium_hidden_intermediate_06177 | Two genes are identified as markers expressed in Natural killer T (NKT) cells, and both are known to interact with HDAC1. One of these genes is described in literature as mechanistically binding to HDAC1 to promote its ubiquitination and degradation, a process that results in the promotion of M2 polarization of macroph... | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06177","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers expressed in Natural killer T (NKT) cells, and both are known to interact with HDAC1. On... | |
medium_hidden_intermediate_06180 | KAT2A interacts with TAF10 via an intermediate protein. Evidence indicates that this intermediate protein interacts with TAF8 (which forms a heterodimer with TAF10) and that these three proteins form a complex in vitro and in vivo. Which protein is encoded by the gene corresponding to this intermediate entity? | STAGA complex 65 subunit gamma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06180","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"KAT2A interacts with TAF10 via an intermediate protein. Evidence indicates that this intermediate protein interacts with TAF... | |
medium_hidden_intermediate_06181 | Measles morbillivirus upregulates a gene that enables ubiquitin protein ligase activity. Evidence for one such gene reports a log2 fold change of 2.064 and an adjusted p-value of 0.04965. Which protein is encoded by that gene? | E3 ubiquitin-protein ligase RNF152 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06181","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that enables ubiquitin protein ligase activity. Evidence for one such gene reports ... | |
medium_hidden_intermediate_06182 | A gene is upregulated by Human gammaherpesvirus 8 and enriched in neutrophils. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 5.150 and an adjusted p-value of 0.03556. Which disease is associated with this gene? | acute myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06182","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and enriched in neutrophils. Experimental data for this gene in a non-Hodg... | |
medium_hidden_intermediate_06185 | Hepacivirus C upregulates a gene that is involved in chromosome segregation. Experimental data for this gene reports a log2 fold change of approximately 1.159 and an adjusted p-value of 0.03386. Which protein is encoded by this gene? | Cytosolic iron-sulfur assembly component 2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06185","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in chromosome segregation. Experimental data for this gene reports a log2 ... | |
medium_hidden_intermediate_06186 | Human betaherpesvirus 5 is known to downregulate certain genes that participate in protein metabolism. One such gene exhibits a log2 fold change of -1.203 and an adjusted p-value of 0.04666 in foreskin fibroblast cells. What molecular function is enabled by this specific gene? | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06186","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate certain genes that participate in protein metabolism. One such gene exhibit... | |
medium_hidden_intermediate_06187 | Rhinovirus A infection is associated with the downregulation of specific genes involved in cell adhesion. One such gene exhibits a log2 fold change of approximately -3.18 and an adjusted p-value of 0.001132 in cytotoxic T-lymphocytes. Which disease is linked to this specific gene through genomic alterations? | end stage renal failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06187","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the downregulation of specific genes involved in cell adhesion. One such gene exhi... | |
medium_hidden_intermediate_06189 | VCP (p97) interacts with a specific protein that is part of a protein-containing complex. Experimental evidence regarding this protein states: 'The PUB domain mediated robust binding to the carboxy-terminus of p97, while the UBX domain did not contribute to p97 binding.' Which gene encodes the protein that interacts wi... | CAV1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06189","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"VCP (p97) interacts with a specific protein that is part of a protein-containing complex. Experimental evidence regarding th... | |
medium_hidden_intermediate_06191 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the mitochondrial matrix. Evidence for this gene reports a log2 fold change of -1.456 and an adjusted p-value of 0.04532. Which protein is encoded by this gene? | Mitochondria-eating protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06191","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the mitochondrial matrix. Evid... | |
medium_hidden_intermediate_06195 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to negative regulation of DNA-templated transcription via an 'involved in' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.012 and an a... | SH3GL2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06195","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_06196 | Vaccinia virus downregulates a specific gene that participates in chromatin modifying enzyme activity. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibited a log2 fold change of -1.484 and an adjusted p-value of 0.02988. Which cellular component is this gene located in? | histone acetyltransferase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06196","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a specific gene that participates in chromatin modifying enzyme activity. In a study of cervica... | |
medium_hidden_intermediate_06197 | Zika virus downregulates a gene that is located in the mitochondrial matrix. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this specific gene has a log2 fold change of approximately -1.49 and an adjusted p-value of approximately 0.014. Which biological process is this gene involved in? | mitochondrion organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06197","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the mitochondrial matrix. Transcriptomic data from glioma stem cells (stu... | |
medium_hidden_intermediate_06198 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with leiomyoma. One of these genes exhibits a log2 fold change of approximately 1.89 and an adjusted p-value of approximately 0.0098 in bronchial epithelial cells. Which disease is linked to this specific gene via a bi... | congenital heart disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06198","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with leiomyoma. One of... | |
medium_hidden_intermediate_06199 | CSNK2A1 interacts with a specific protein that enables protein binding. Evidence indicates that Casein kinase 2 (CK2) directly interacts with and phosphorylates this protein at Thr122, a modification that promotes the stability of the protein. Which protein is encoded by the gene corresponding to this entity? | Ubiquitin carboxyl-terminal hydrolase 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06199","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CSNK2A1 interacts with a specific protein that enables protein binding. Evidence indicates that Casein kinase 2 (CK2) direct... | |
medium_hidden_intermediate_06200 | Zika virus downregulates a gene that participates in ER to Golgi anterograde transport. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -1.349 and an adjusted p-value of 0.03531. Which protein is encoded by this gene? | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06200","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in ER to Golgi anterograde transport. In a study of glioma stem cells (GSE... | |
medium_hidden_intermediate_06202 | COPS5 interacts with a specific protein that is involved in the regulation of transcription by RNA polymerase II. Experimental evidence indicates that this protein interacts with JAB1 and c-Jun, but does not interact with JunB or v-Jun. Which protein is encoded by the gene corresponding to this interacting partner? | Transcription factor JunD | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06202","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"COPS5 interacts with a specific protein that is involved in the regulation of transcription by RNA polymerase II. Experiment... | |
medium_hidden_intermediate_06203 | A gene is upregulated by Primate bocaparvovirus 1 and enables signaling receptor binding. Experimental evidence for this gene reports a log2 fold change of 1.825 and an adjusted p-value of 0.02664. Which protein is encoded by this gene? | Leukemia inhibitory factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06203","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and enables signaling receptor binding. Experimental evidence for this gen... | |
medium_hidden_intermediate_06204 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in cell adhesion. Evidence for this specific gene reports a log2 fold change of -1.910 and an adjusted p-value of 3.302e-05. Which protein is encoded by this gene? | Kin of IRRE-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06204","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in cell adhesion. Evidence for t... | |
medium_hidden_intermediate_06205 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in hemostasis. Transcriptomic data for this gene shows a log2 fold change of 2.410 and an adjusted p-value of 0.0164. In which cell type is this gene enriched? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06205","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in hemostasis. T... | |
medium_hidden_intermediate_06208 | Hepacivirus C downregulates a gene that is involved in the ether lipid metabolic process. Experimental data for one such gene reports a log2 fold change of -1.095 and an adjusted p-value of 0.0006557. Which protein is encoded by this gene? | Alkylglycerol monooxygenase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06208","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that is involved in the ether lipid metabolic process. Experimental data for one such gen... | |
medium_hidden_intermediate_06209 | A gene is upregulated by Human gammaherpesvirus 8 and is enriched in plasmacytoid dendritic cells. Evidence for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 1.883 and an adjusted p-value of 0.02463. Which protein is encoded by this gene? | Ceramide glucosyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06209","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and is enriched in plasmacytoid dendritic cells. Evidence for this gene in... | |
medium_hidden_intermediate_06211 | SCN5A is involved in a biological process that is a type of membrane depolarization during cardiac muscle cell action potential. Evidence for one such process describes it as the process in which the bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting pot... | bundle of His cell action potential | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06211","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"SCN5A is involved in a biological process that is a type of membrane depolarization during cardiac muscle cell action potent... | |
medium_hidden_intermediate_06212 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that participates in phospholipid metabolism. This gene exhibited a log2 fold change of approximately 1.16 and an adjusted p-value of 0.001052. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06212","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that parti... | |
medium_hidden_intermediate_06213 | Zika virus downregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.63 and an adjusted p-value of approximately 0.0105. Which cellular component is this gene locate... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06213","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Evidence ... | |
medium_hidden_intermediate_06214 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in the Generic Transcription Pathway. Experimental data for this gene in foreskin fibroblast cell lines indicates a log2 fold change of -1.041 and an adjusted p-value of 0.04685. Which protein is encoded by this gene? | Cytochrome c oxidase subunit 7A2-like, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06214","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in the Generic Transcription Pathway. Experimen... | |
medium_hidden_intermediate_06215 | Hepacivirus C is reported to downregulate a gene that enables guanyl-nucleotide exchange factor activity. In a specific study, this gene exhibited a log2 fold change of approximately -2.02 and an adjusted p-value of 0.0269. Which gene interacts with this downregulated gene? | CCDC120 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06215","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables guanyl-nucleotide exchange factor activity. In a specific stud... | |
medium_hidden_intermediate_06216 | Two distinct drugs are known to interact with both Urokinase and Garlic. One of these drugs has documented evidence regarding its safety and efficacy when used in conjunction with intracoronary urokinase in patients requiring angioplasty. Which disease is the drug identified by this specific clinical evidence indicated... | intermediate coronary syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06216","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are known to interact with both Urokinase and Garlic. One of these drugs has documented evidence regardin... | |
medium_hidden_intermediate_06218 | Hepacivirus C upregulates a gene that participates in Class I MHC mediated antigen processing & presentation. Evidence for one such gene reports a log2 fold change of 1.361 and an adjusted p-value of 0.0007029. Which protein is encoded by that gene? | Kelch-like protein 21 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06218","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in Class I MHC mediated antigen processing & presentation. Evidence for o... | |
medium_hidden_intermediate_06220 | Hepacivirus C is known to upregulate a specific gene, which in turn binds to ACVR2A. Experimental data for this intermediate gene reports a log2 fold change of approximately 1.473 and an adjusted p-value of 0.0002468. Which disease is associated with this gene as a biomarker? | colitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06220","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is known to upregulate a specific gene, which in turn binds to ACVR2A. Experimental data for this intermediate... | |
medium_hidden_intermediate_06221 | Measles morbillivirus upregulates a gene that is involved in protein K11-linked ubiquitination. Evidence for this specific gene reports a log2 fold change of 1.786 and an adjusted p-value of 0.0001868. Which cellular component is this gene located in? | anaphase-promoting complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06221","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in protein K11-linked ubiquitination. Evidence for this specific g... | |
medium_hidden_intermediate_06222 | Zika virus downregulates a gene that is associated with lipoma. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.023 and an adjusted p-value of 0.03336. Which protein is encoded by this gene? | SPRY domain-containing protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06222","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is associated with lipoma. In a study of glioma stem cells (GSE114907), this gene exhib... | |
medium_hidden_intermediate_06223 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the mitotic cell cycle. One of these genes exhibits a log2 fold change of approximately 1.92 and an adjusted p-value of approximately 0.023 in a specific study. Which biological process is this specific gene involved i... | mitotic chromosome condensation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06223","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the mitotic cell cycle... | |
medium_hidden_intermediate_06227 | A gene is upregulated by Primate bocaparvovirus 1 and participates in Glycosaminoglycan metabolism. Evidence for this gene reports a log2 fold change of 1.476 and an adjusted p-value of 0.02289. Which cellular component is this gene located in? | trans-Golgi network | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06227","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in Glycosaminoglycan metabolism. Evidence for this gene r... | |
medium_hidden_intermediate_06230 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is upregulated by the virus and interacts with CUL3. This gene exhibits a log2 fold change of 2.501 and an adjusted p-value of 0.0007093. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06230","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is upregulated by the virus and interacts ... | |
medium_hidden_intermediate_06233 | Zaire ebolavirus downregulates a specific gene that is enriched in eosinophils. Transcriptomic data from a study on retinal pigment epithelium cells (GSE100839) indicates that this gene has a log2 fold change of -3.342 and an adjusted p-value of 0.005215. What molecular function is enabled by this gene? | G protein-coupled receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06233","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a specific gene that is enriched in eosinophils. Transcriptomic data from a study on retinal ... | |
medium_hidden_intermediate_06234 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that enable zinc ion binding. One such gene exhibited a log2 fold change of 1.697 and an adjusted p-value of 2.958e-05. Which protein is encoded by this specific gene? | Zinc finger protein OZF | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06234","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that... | |
medium_hidden_intermediate_06237 | In a study of cervical adenocarcinoma cell lines (GSE11238), a specific gene is upregulated by Vaccinia virus and interacts with KIAA0753. This gene exhibits a log2 fold change of 1.192 and an adjusted p-value of 0.0008256. Which protein is encoded by this gene? | Coiled-coil domain-containing protein 138 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06237","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a specific gene is upregulated by Vaccinia virus and interacts ... | |
medium_hidden_intermediate_06238 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), two genes are upregulated and involved in epithelial cell differentiation. One of these genes exhibits a log2 fold change of 5.459 and an adjusted p-value of 0.003234. Which protein is encoded by this specific gene... | Ammonium transporter Rh type C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06238","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), two genes are upre... | |
medium_hidden_intermediate_06240 | Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and associated with melanoma. One of these genes exhibits a log2 fold change of -1.139 and an adjusted p-value of 0.02686 in a specific study. Which disease is linked to this specific gene through genomic alterations? | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06240","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and associated with melanoma. One ... |
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