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medium_hidden_intermediate_07585 | Two genes are each linked to Human betaherpesvirus 5 via a downregulation relationship and to bipolar disorder via a biomarker relationship. One of these genes is associated with a study reporting a log2 fold change of -1.254 and an adjusted p-value of 0.04631. Which gene interacts with the gene identified by these spe... | STK4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07585","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each linked to Human betaherpesvirus 5 via a downregulation relationship and to bipolar disorder via a biomark... | |
medium_hidden_intermediate_07587 | Human immunodeficiency virus 1 downregulates a gene that is located in the extracellular region. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.432 and an adjusted p-value of 0.00739. Which protein is encoded by this gene? | Chemokine-like factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07587","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the extracellular region. In a study of macrophages (... | |
medium_hidden_intermediate_07591 | A gene is downregulated by Human gammaherpesvirus 8 and is enriched in plasmacytoid dendritic cells. Evidence for this gene reports a log2 fold change of -1.453 and an adjusted p-value of 0.01538. Which protein is encoded by this gene? | DNA-binding protein REPIN1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07591","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and is enriched in plasmacytoid dendritic cells. Evidence for this gene ... | |
medium_hidden_intermediate_07592 | Enterovirus A is reported to upregulate a specific gene, which is in turn associated with pancreatic neoplasm. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) indicate a log2 fold change of approximately 2.19 and an adjusted p-value of approximately 0.015. What protein is encoded by this gen... | Tumor necrosis factor receptor superfamily member 10A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07592","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to upregulate a specific gene, which is in turn associated with pancreatic neoplasm. Experimental ... | |
medium_hidden_intermediate_07593 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to Peroxisomal protein import via a 'participates in' relationship. One of these genes has been reported in a study with a log2 fold change of approximately 1.714 and an adjusted p-value of 0... | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07593","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_07595 | Zika virus downregulates a specific gene, which in turn interacts with the protein EAPP. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of -2.312 and an adjusted p-value of 0.01834. Which protein is encoded by this gene? | Protein ecdysoneless homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07595","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with the protein EAPP. Experimental data from glioma stem ... | |
medium_hidden_intermediate_07597 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in the Senescence-Associated Secretory Phenotype (SASP). Evidence for this gene reports a log2 fold change of 4.295 and an adjusted p-value of 0.0125. Which protein is encoded by this gene? | Histone H3.1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07597","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participat... | |
medium_hidden_intermediate_07598 | Two genes are upregulated by Human immunodeficiency virus 1 and interact with PRKN. One of these genes shows a log2 fold change of 1.752 and an adjusted p-value of 0.000392 in a specific study. Which cell type is enriched for that specific gene? | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07598","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and interact with PRKN. One of these genes shows a log2 fold cha... | |
medium_hidden_intermediate_07599 | A gene is downregulated by Primate bocaparvovirus 1 and participates in post-translational protein modification. Experimental data for this gene in umbilical vein endothelial cells (study GSE119608) shows a log2 fold change of approximately -1.093 and an adjusted p-value of 0.02608. Which biological process is this gen... | protein hydroxylation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07599","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in post-translational protein modification. Experimenta... | |
medium_hidden_intermediate_07600 | Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of transcription by RNA polymerase II. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of 3.441 and an adjusted p-value of 7.663e-07. Which protein is encoded by this gene? | Transcription cofactor HES-6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07600","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of transcription by RNA polyme... | |
medium_hidden_intermediate_07601 | Vaccinia virus infection leads to the upregulation of specific genes that are localized to the lysosomal membrane. One such gene exhibits a log2 fold change of 2.418 and an adjusted p-value of 1.458e-08 in cervical adenocarcinoma cells. In which cell type is this specific gene enriched? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07601","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection leads to the upregulation of specific genes that are localized to the lysosomal membrane. One such ... | |
medium_hidden_intermediate_07602 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with PRMT6. Evidence for one such gene reports a log2 fold change of -1.055 and an adjusted p-value of 0.000559. Which protein is encoded by that gene? | Secretion-regulating guanine nucleotide exchange factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07602","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with PRMT6. Evidence for one such ... | |
medium_hidden_intermediate_07603 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with USP10. Evidence for one such gene reports a log2 fold change of -1.043 and an adjusted p-value of 0.04975. Which protein is encoded by that gene? | Disheveled-associated activator of morphogenesis 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07603","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with USP10. Evidence for one such ... | |
medium_hidden_intermediate_07604 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to bind TUBB4B was found to have a log2 fold change of 1.396 and an adjusted p-value of 0.0009684. Which disease is associated with this specific gene? | mirror movements 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07604","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to bind TUBB4B w... | |
medium_hidden_intermediate_07605 | Hepacivirus C upregulates a gene that is involved in the ERAD pathway. Evidence for one such gene reports a log2 fold change of 1.529 and an adjusted p-value of 0.02451. Which gene interacts with the gene identified by this evidence? | CAV1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07605","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the ERAD pathway. Evidence for one such gene reports a log2 fold change... | |
medium_hidden_intermediate_07606 | Measles morbillivirus upregulates a gene that participates in the metabolism of lipids. Experimental data for one such gene reports a log2 fold change of 1.475 and an adjusted p-value of 0.002997. Which protein is encoded by this gene? | Aldo-keto reductase family 1 member B1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07606","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the metabolism of lipids. Experimental data for one such gene ... | |
medium_hidden_intermediate_07607 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for breast carcinoma. One of these genes exhibits a log2 fold change of approximately 1.16 and an adjusted p-value of 0.0124 in lung tissue data from study GSE155241. Which disease is associated with this specific... | rheumatoid arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07607","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for breast carcin... | |
medium_hidden_intermediate_07608 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of the collagen biosynthetic process. One of these genes exhibits a log2 fold change of approximately 1.95 and an adjusted p-value of approximately 4.83e-05 in a specific study. Which disease i... | adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07608","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulati... | |
medium_hidden_intermediate_07609 | In a study of Measles morbillivirus infection, two genes are downregulated and subsequently associated with anxiety. One of these genes exhibits a log2 fold change of approximately -1.457 and an adjusted p-value of 0.004447. Which protein is encoded by this specific gene? | Fatty acid-binding protein, heart | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07609","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are downregulated and subsequently associated with anxiety. One of ... | |
medium_hidden_intermediate_07610 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Ub-specific processing proteases. Evidence for this gene reports a log2 fold change of 1.846 and an adjusted p-value of 0.01274. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07610","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Ub-specific processing pr... | |
medium_hidden_intermediate_07611 | Hepacivirus C downregulates a gene that is involved in actin cytoskeleton organization. Evidence for one such gene reports a log2 fold change of -1.336 and an adjusted p-value of 0.004096. Which protein is encoded by that gene? | GAS2-like protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07611","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that is involved in actin cytoskeleton organization. Evidence for one such gene reports a... | |
medium_hidden_intermediate_07612 | Zika virus downregulates a gene that participates in the metabolism of fat-soluble vitamins. Experimental data from glioma stem cells (study GSE114907) indicate that this gene has a log2 fold change of approximately -2.005 and an adjusted p-value of 0.007849. Which protein is encoded by this gene? | Low-density lipoprotein receptor-related protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07612","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the metabolism of fat-soluble vitamins. Experimental data from glioma s... | |
medium_hidden_intermediate_07613 | Human immunodeficiency virus 1 upregulates a gene that is involved in the immune response. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 3.06 and an adjusted p-value of 0.0118. Which protein is encoded by this gene? | Programmed cell death 1 ligand 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07613","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the immune response. In a study of macrophages (GSE108... | |
medium_hidden_intermediate_07614 | Zika virus downregulates a gene that is involved in the positive regulation of the MAPK cascade. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.67 and an adjusted p-value of approximately 0.0147. Which protein does this gene interact with? | BCAR1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07614","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the positive regulation of the MAPK cascade. In a study of glioma stem c... | |
medium_hidden_intermediate_07615 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with ulcer disease. Experimental data for this gene reports a log2 fold change of approximately 1.407 and an adjusted p-value of 0.03904. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07615","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with ulcer disease. Experim... | |
medium_hidden_intermediate_07616 | Hepacivirus C upregulates a gene that is enriched in peripheral blood mononuclear cells. Evidence for this gene reports a log2 fold change of approximately 1.29 and an adjusted p-value of 0.034. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07616","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is enriched in peripheral blood mononuclear cells. Evidence for this gene reports a lo... | |
medium_hidden_intermediate_07617 | Pegivirus C is reported to downregulate a gene that is involved in phospholipid transfer to the membrane. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.675 and an adjusted p-value of 0.002033. Which protein is encoded by this specific gene? | Oxysterol-binding protein-related protein 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07617","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in phospholipid transfer to the membrane. In a study of peri... | |
medium_hidden_intermediate_07618 | Human immunodeficiency virus 1 downregulates a gene that enables ubiquitin protein ligase binding. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately -1.26 and an adjusted p-value of 0.0033. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07618","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that enables ubiquitin protein ligase binding. In a study of macrophages... | |
medium_hidden_intermediate_07619 | Zaire ebolavirus infection upregulates a gene that is involved in the defense response to Gram-positive bacteria. In a study of retinal pigment epithelium cells (GSE100839), one such upregulated gene exhibited a log2 fold change of 1.667 and an adjusted p-value of 0.0001603. Which protein is encoded by this specific ge... | Beta-defensin 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07619","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection upregulates a gene that is involved in the defense response to Gram-positive bacteria. In a study... | |
medium_hidden_intermediate_07621 | Zika virus downregulates a gene that is located in the mitochondrial matrix. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -2.15 and an adjusted p-value of 0.0096. Which protein is encoded by this specific gene? | Dihydrofolate reductase 2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07621","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the mitochondrial matrix. In a study of glioma stem cells (GSE114907), on... | |
medium_hidden_intermediate_07624 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of certain genes that enable ATP binding. One such gene exhibits a log2 fold change of approximately -1.49 and an adjusted p-value of 0.0134. Which protein is encoded by this specific gene? | Mitogen-activated protein kinase kinase kinase kinase 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07624","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of certain... | |
medium_hidden_intermediate_07626 | Two genes are each upregulated by Enterovirus A and associated with breast carcinoma. One of these genes exhibits a log2 fold change of approximately 2.90 and an adjusted p-value of approximately 0.0019 in rhabdomyosarcoma cells (study GSE103308). Which protein interacts with this specific gene? | FOXP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07626","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Enterovirus A and associated with breast carcinoma. One of these genes exhibits a log2 fol... | |
medium_hidden_intermediate_07627 | Two genes are structurally linked to Vaccinia virus via a 'downregulates' relationship and to 'DNA-binding transcription activator activity, RNA polymerase II-specific' via an 'enables' relationship. One of these genes has a reported log2 fold change of -1.639 and an adjusted p-value of 0.006276 in a specific study. Wh... | adenoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07627","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Vaccinia virus via a 'downregulates' relationship and to 'DNA-binding transcription act... | |
medium_hidden_intermediate_07629 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PTEN. One of these genes shows a log2 fold change of 1.025 and an adjusted p-value of 5.209e-08 in a specific study. Which disease is associated with this gene? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07629","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PTEN. One of these gene... | |
medium_hidden_intermediate_07632 | In a study of Measles morbillivirus infection, certain genes are upregulated and serve as biomarkers for schizophrenia. One such gene exhibits a log2 fold change of 1.304 and an adjusted p-value of 0.001444. Which protein is encoded by this specific gene? | SLIT-ROBO Rho GTPase-activating protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07632","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, certain genes are upregulated and serve as biomarkers for schizophrenia. One ... | |
medium_hidden_intermediate_07634 | Ileitis is associated with multiple anatomical structures via localization. One such structure is an organ described as the body covering consisting of the dermis and epidermis. Which anatomical entity is this organ a part of? | integument | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07634","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Ileitis is associated with multiple anatomical structures via localization. One such structure is an organ described as the ... | |
medium_hidden_intermediate_07636 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the fatty acid metabolic process. One of these genes exhibits a log2 fold change of 1.013 and an adjusted p-value of 0.03543 in a specific study. Which disease is associated with this gene as a biomarker? | hypertensive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07636","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the fatty acid metabo... | |
medium_hidden_intermediate_07637 | Zika virus downregulates a gene that enables phospholipid binding. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.02 and an adjusted p-value of 0.0175. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07637","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables phospholipid binding. In a study of glioma stem cells (GSE114907), this gene ex... | |
medium_hidden_intermediate_07638 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cardiac conduction. Evidence for this gene reports a log2 fold change of -1.322 and an adjusted p-value of 0.007343. Which cellular component is this gene located in? | mitochondrial outer membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07638","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cardiac conduction. Evi... | |
medium_hidden_intermediate_07641 | Rhinovirus A infection is associated with the upregulation of specific genes that participate in sensory perception. In a study of cytotoxic T-lymphocytes (GSE106475), one such gene exhibited a log2 fold change of 1.226 and an adjusted p-value of 0.006304. Which protein is encoded by this gene? | Retinol dehydrogenase 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07641","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the upregulation of specific genes that participate in sensory perception. In a st... | |
medium_hidden_intermediate_07643 | A gene is upregulated by Primate bocaparvovirus 1 and is associated with leukemia. Experimental evidence for this gene reports a log2 fold change of approximately 1.75 and an adjusted p-value of approximately 0.0404. Which disease is linked to this gene via a biomarker relationship? | ovarian neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07643","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is associated with leukemia. Experimental evidence for this gene repor... | |
medium_hidden_intermediate_07646 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that enable cadherin binding. One such gene exhibited a log2 fold change of approximately 1.90 and an adjusted p-value of 4.49e-06. Which protein does this specific gene product bind to? | XPO1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07646","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_07647 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with thyroid gland papillary carcinoma. Evidence for this gene reports a log2 fold change of 1.320 and an adjusted p-value of 0.002683. Which molecular function is enabled by this gene? | UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07647","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with thyroid gland papillar... | |
medium_hidden_intermediate_07648 | A specific protein interacts with CDC42 and is involved in protein binding. Experimental evidence indicates that a member of the Borg protein family binds both TC10 and Cdc42 in a GTP-dependent manner. Which disease is associated with this protein as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07648","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific protein interacts with CDC42 and is involved in protein binding. Experimental evidence indicates that a member of... | |
medium_hidden_intermediate_07649 | Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to extracellular exosome via a 'located in' relationship. One of these genes has an associated experimental record showing a log2 fold change of -2.145 and an adjusted p-value of 0.02262. Which cell type is connected to this speci... | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07649","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to extracellular exosome via a 'lo... | |
medium_hidden_intermediate_07650 | Zika virus downregulates a gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -3.607 and an adjusted p-value of 0.01859. Which protein is encoded by this specific gene? | Leucine-rich repeat-containing protein 58 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07650","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. I... | |
medium_hidden_intermediate_07651 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables protein folding chaperone activity. Evidence for one such gene reports a log2 fold change of 1.096 and an adjusted p-value of 0.04402. Which protein is encoded by that gene? | Prefoldin subunit 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07651","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables protein folding chaperone activity. Ev... | |
medium_hidden_intermediate_07652 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enables DNA-binding transcription factor activity. This specific gene exhibits a log2 fold change of -1.569 and an adjusted p-value of 0.01823. Which protein is encoded by this gene? | Zinc finger protein 90 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07652","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enab... | |
medium_hidden_intermediate_07654 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and involved in the positive regulation of transcription by RNA polymerase II. This gene exhibits a log2 fold change of approximately 1.026 and an adjusted p-value of 2.235e-05. Which cellular componen... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07654","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_07655 | Zika virus downregulates a specific gene, which in turn interacts with HSPA8. Experimental data for this gene indicates a log2 fold change of -1.100 and an adjusted p-value of 0.01834. In which cell type is this gene enriched? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07655","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with HSPA8. Experimental data for this gene indicates a lo... | |
medium_hidden_intermediate_07656 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in calmodulin-induced events. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this gene has a log2 fold change of approximately -1.74 and an adjusted p-value of 0.00014. Which protein is enco... | Adenylate cyclase type 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07656","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in calmodulin-induced events. Transcript... | |
medium_hidden_intermediate_07657 | Zika virus downregulates a gene that participates in the transcription of E2F targets under negative control by the DREAM complex. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.647 and an adjusted p-value of 0.0147. Which protein is encoded by this specific gene? | Protein lin-37 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07657","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the transcription of E2F targets under negative control by the DREAM co... | |
medium_hidden_intermediate_07658 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in the Immune System. Evidence for this gene reports a log2 fold change of 2.517 and an adjusted p-value of 0.003268. Which protein is encoded by this gene? | Serpin B3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07658","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in the Immune System... | |
medium_hidden_intermediate_07659 | Measles morbillivirus upregulates a gene that participates in COPI-dependent Golgi-to-ER retrograde traffic. Evidence for one such gene reports a log2 fold change of 1.355 and an adjusted p-value of 0.01331. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07659","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in COPI-dependent Golgi-to-ER retrograde traffic. Evidence for on... | |
medium_hidden_intermediate_07660 | Zika virus downregulates a gene that participates in rRNA processing in the nucleus and cytosol. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.342 and an adjusted p-value of 0.01701. Which protein is encoded by this gene? | Ribosomal RNA processing protein 1 homolog A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07660","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in rRNA processing in the nucleus and cytosol. In a study of glioma stem c... | |
medium_hidden_intermediate_07662 | Human immunodeficiency virus 1 upregulates a gene that enables RNA binding. Evidence for this gene reports a log2 fold change of 2.939 and an adjusted p-value of 6.065e-05. Which protein is encoded by this gene? | RPA-related protein RADX | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07662","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables RNA binding. Evidence for this gene reports a log2 fold chang... | |
medium_hidden_intermediate_07664 | Pegivirus C is reported to downregulate a gene that participates in selenoamino acid metabolism. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.847 and an adjusted p-value of 0.02201. Which protein is encoded by this specific gene? | Histamine N-methyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07664","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in selenoamino acid metabolism. In a study of peripheral bl... | |
medium_hidden_intermediate_07666 | Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that is associated with adenocarcinoma. One such gene exhibits a log2 fold change of -1.560 and an adjusted p-value of 0.03771 in a specific study. Which protein is encoded by this gene? | Serpin B7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07666","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that is associated with adenocarcin... | |
medium_hidden_intermediate_07667 | Hepacivirus C is known to downregulate certain genes that participate in lipid metabolism. One such gene exhibits a log2 fold change of approximately -1.09 and an adjusted p-value of 0.0155 in hepatocytes. Which protein interacts with this specific gene product? | SNCA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07667","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is known to downregulate certain genes that participate in lipid metabolism. One such gene exhibits a log2 fol... | |
medium_hidden_intermediate_07669 | Pegivirus C is reported to downregulate a gene that is involved in RNA splicing. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.568 and an adjusted p-value of 0.001526. Which protein is encoded by this specific gene? | Nuclear exosome regulator NRDE2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07669","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in RNA splicing. In a study of peripheral blood mononuclear ... | |
medium_hidden_intermediate_07672 | Human betaherpesvirus 5 is reported to downregulate a specific gene, which in turn interacts with GOLPH3. Experimental data from a study on foreskin fibroblast cell lines (GSE111036) indicates that this gene has a log2 fold change of approximately -2.024 and an adjusted p-value of 0.047. Which protein is encoded by thi... | Golgi apparatus protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07672","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene, which in turn interacts with GOLPH3. Experimental data ... | |
medium_hidden_intermediate_07674 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of Rho protein signal transduction. One of these genes exhibits a log2 fold change of approximately 3.03 and an adjusted p-value of 0.025 in sclera tissue data from study GSE164073. Which disea... | clear cell renal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07674","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulati... | |
medium_hidden_intermediate_07677 | Human betaherpesvirus 5 upregulates a gene that is located in the extracellular region. Evidence for this specific gene reports a log2 fold change of 4.268 and an adjusted p-value of 0.02466. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07677","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is located in the extracellular region. Evidence for this specific gene repo... | |
medium_hidden_intermediate_07678 | Zika virus infection leads to the upregulation of specific genes, some of which are enriched in non-classical monocytes. One such gene exhibits a log2 fold change of 2.542 and an adjusted p-value of 0.003479 in neural stem cells. Which protein is encoded by this gene? | Protein mono-ADP-ribosyltransferase PARP12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07678","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the upregulation of specific genes, some of which are enriched in non-classical monocytes. One... | |
medium_hidden_intermediate_07679 | Two genes are upregulated by Vaccinia virus and participate in axon guidance. One of these genes shows a log2 fold change of approximately 1.96 and an adjusted p-value of 0.0005359 in cervical adenocarcinoma cell lines. Which disease is associated with genomic alterations in this specific gene? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07679","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in axon guidance. One of these genes shows a log2 fold change of... | |
medium_hidden_intermediate_07680 | Human betaherpesvirus 5 upregulates a gene that enables identical protein binding. Evidence for this specific gene reports a log2 fold change of 1.733 and an adjusted p-value of 2.462e-07. Which biological process is this gene involved in? | NK T cell activation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07680","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that enables identical protein binding. Evidence for this specific gene reports a... | |
medium_hidden_intermediate_07681 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with ulcerative colitis. Experimental data for this gene reports a log2 fold change of -1.887 and an adjusted p-value of 0.004154. Which protein is encoded by this gene? | Lactadherin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07681","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with ulcerative colitis. ... | |
medium_hidden_intermediate_07682 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, two genes are upregulated and involved in the positive regulation of transcription by RNA polymerase II. One of these genes exhibits a log2 fold change of approximately 1.307 and an adjusted p-value of 1.566e-11. Which protein is en... | Protein lin-54 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07682","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, two genes are upregulated and involv... | |
medium_hidden_intermediate_07684 | Measles morbillivirus upregulates a gene that participates in ion transport by P-type ATPases. Evidence for one such gene reports a log2 fold change of 1.390 and an adjusted p-value of 0.001173. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07684","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in ion transport by P-type ATPases. Evidence for one such gene re... | |
medium_hidden_intermediate_07685 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene that participates in vesicle-mediated transport. This gene exhibits a log2 fold change of approximately -1.66 and an adjusted p-value of approximately 0.035. Which biological process is t... | protein geranylgeranylation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07685","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_07688 | Zika virus downregulates a gene that is involved in the negative regulation of translation. Experimental data from glioma stem cells (study GSE114907) indicates that this specific gene has a log2 fold change of -2.948 and an adjusted p-value of 0.008316. Which protein is encoded by this gene? | Ephrin type-A receptor 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07688","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the negative regulation of translation. Experimental data from glioma st... | |
medium_hidden_intermediate_07689 | Human immunodeficiency virus 1 upregulates a gene that participates in diseases of programmed cell death. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of 1.459 and an adjusted p-value of 0.0004901. Which protein is encoded by this gene? | M-phase inducer phosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07689","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in diseases of programmed cell death. Evidence for this ... | |
medium_hidden_intermediate_07690 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene, which in turn participates in the transport of small molecules. This gene exhibited a log2 fold change of -1.345 and an adjusted p-value of 0.01456. Which protein is encoded by this gene? | Phospholipid-transporting ATPase IF | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07690","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_07691 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus and involved in the positive regulation of transcription by RNA polymerase II was found to have a log2 fold change of -2.154 and an adjusted p-value of 0.03822. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07691","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus and involved in the posi... | |
medium_hidden_intermediate_07694 | Human betaherpesvirus 5 is reported to downregulate a gene that enables ATP binding. In a study using foreskin fibroblast cell lines, this gene exhibited a log2 fold change of -1.639 and an adjusted p-value of 0.02463. Which gene interacts with this downregulated entity? | MAD2L1BP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07694","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that enables ATP binding. In a study using foreskin fibroblast ce... | |
medium_hidden_intermediate_07696 | Human immunodeficiency virus 1 upregulates a gene that is associated with renal cell carcinoma. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of 3.423 and an adjusted p-value of 0.008371. Which protein is encoded by this gene? | Delta-like protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07696","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with renal cell carcinoma. In a study of macrophages (G... | |
medium_hidden_intermediate_07697 | A gene is upregulated by Human immunodeficiency virus 1 and located in the perinuclear region of the cytoplasm. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 1.23 and an adjusted p-value of approximately 0.0021. Which disease is associated with this ge... | typhoid fever | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07697","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and located in the perinuclear region of the cytoplasm. Experimental... | |
medium_hidden_intermediate_07698 | Measles morbillivirus upregulates a gene that is involved in the DNA damage response. Experimental data for one such gene reports a log2 fold change of approximately 2.40 and an adjusted p-value of approximately 0.00046. Which protein is encoded by this specific gene? | Protein CIP2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07698","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the DNA damage response. Experimental data for one such gene re... | |
medium_hidden_intermediate_07700 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SNRPF. One of these genes shows a log2 fold change of approximately 1.029 and an adjusted p-value of 0.007199 in a specific study. Which cell type is this gene enriched in? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07700","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SNRPF. One of these gen... | |
medium_hidden_intermediate_07701 | A gene is downregulated by Primate bocaparvovirus 1 and associated with carcinoma. Evidence for this gene reports a log2 fold change of -1.653 and an adjusted p-value of 0.003347. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07701","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and associated with carcinoma. Evidence for this gene reports a log2 fol... | |
medium_hidden_intermediate_07702 | A protein entity is linked to ARCN1 via a binding interaction and is involved in vesicle-mediated transport. Experimental evidence, including immunoprecipitation and two-hybrid analysis from a complete COP screen, demonstrates physical interactions between alpha- and epsilon-COPs, as well as between beta- and delta-COP... | Coatomer subunit beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07702","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein entity is linked to ARCN1 via a binding interaction and is involved in vesicle-mediated transport. Experimental ev... | |
medium_hidden_intermediate_07703 | Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with acute leukemia. One of these genes exhibits a log2 fold change of 3.403 and an adjusted p-value of 0.01712 in a specific study. Which cellular component is the location of this specific gene? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07703","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with acute leukemia. ... | |
medium_hidden_intermediate_07704 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in neuron cell-cell adhesion. Experimental data for this gene reports a log2 fold change of -1.139 and an adjusted p-value of 0.03641. Which protein is encoded by this gene? | Neuroligin-4, Y-linked | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07704","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in neuron cell-cell adhesio... | |
medium_hidden_intermediate_07706 | Human immunodeficiency virus 1 downregulates a gene that is involved in collagen fibril organization. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -2.149 and an adjusted p-value of 0.0005776. Which protein is encoded by this gene? | Peroxidasin homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07706","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in collagen fibril organization. In a study of macropha... | |
medium_hidden_intermediate_07708 | Zika virus downregulates a specific gene, which in turn participates in Co-inhibition by PD-1. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.77 and an adjusted p-value of 0.009654. Which protein is encoded by this gene? | Histone H3.3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07708","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn participates in Co-inhibition by PD-1. Experimental data for this ge... | |
medium_hidden_intermediate_07709 | Zika virus downregulates a gene that interacts with SQSTM1. In glioma stem cells, one such gene exhibits a log2 fold change of -1.699 and an adjusted p-value of 0.009859. Which protein is encoded by this gene? | Uncharacterized protein C1orf198 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07709","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with SQSTM1. In glioma stem cells, one such gene exhibits a log2 fold change ... | |
medium_hidden_intermediate_07710 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables magnesium ion binding. Transcriptomic data for this gene shows a log2 fold change of approximately 1.04 and an adjusted p-value of approximately 0.04. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07710","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables magnesium ion binding. Transcript... | |
medium_hidden_intermediate_07711 | In a study of non-small cell lung adenocarcinoma cell lines infected with Influenza A virus, a specific gene located in the mitochondrion was found to be upregulated. This gene exhibited a log2 fold change of 1.359 and an adjusted p-value of 2.472e-05. Which disease is associated with this gene? | gastric carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07711","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines infected with Influenza A virus, a specific gene located in the ... | |
medium_hidden_intermediate_07712 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn interacts with ZNF622. This gene exhibited a log2 fold change of -1.729 and an adjusted p-value of 0.02937. Which protein is encoded by this gene? | Large subunit GTPase 1 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07712","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn i... | |
medium_hidden_intermediate_07716 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes involved in tRNA processing. One such gene exhibited a log2 fold change of 1.277 and an adjusted p-value of 0.009749. Which protein does this specific gene product bind to? | TRMT61A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07716","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes involved in ... | |
medium_hidden_intermediate_07717 | Hepacivirus C upregulates a gene that enables signaling receptor binding. Evidence for one such gene in hepatocytes (from study GSE132606) reports a log2 fold change of approximately 1.68 and an adjusted p-value of 0.0036. Which disease is associated with genomic alterations in this specific gene? | tuberculosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07717","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables signaling receptor binding. Evidence for one such gene in hepatocytes (from st... | |
medium_hidden_intermediate_07718 | Hepacivirus C upregulates a gene that participates in the response to elevated platelet cytosolic Ca2+. Evidence for one such gene reports a log2 fold change of approximately 1.97 and an adjusted p-value of approximately 0.017. Which protein does this gene product interact with? | SNX17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07718","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the response to elevated platelet cytosolic Ca2+. Evidence for one suc... | |
medium_hidden_intermediate_07724 | Pegivirus C is reported to downregulate a specific gene that participates in Signaling by Rho GTPases. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of approximately -1.815 and an adjusted p-value of 0.001261. Which cellular component is this gene located in? | mitochondrial matrix | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07724","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that participates in Signaling by Rho GTPases. In a study of periphe... | |
medium_hidden_intermediate_07726 | Two distinct proteins form a binding bridge between ABRAXAS1 and HERC2. One of these proteins is identified in the literature as a Rap80-associated protein essential for BRCA1-Rap80 complex interactions, stability, and double-strand break targeting. Which protein is encoded by the gene corresponding to this entity? | BRISC and BRCA1-A complex member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07726","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct proteins form a binding bridge between ABRAXAS1 and HERC2. One of these proteins is identified in the literatur... | |
medium_hidden_intermediate_07728 | Hepacivirus C is reported to upregulate multiple genes that are subsequently associated with acute leukemia. One such gene exhibits a log2 fold change of approximately 1.013 and an adjusted p-value of 4.282e-07 in a specific study. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07728","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate multiple genes that are subsequently associated with acute leukemia. One such gene e... | |
medium_hidden_intermediate_07729 | Pegivirus C is reported to downregulate a gene that is located in the mitochondrial inner membrane. Evidence for one such gene reports a log2 fold change of -1.901 and an adjusted p-value of 0.008122. Which protein is encoded by that gene? | Mitochondrial ribosome-associated GTPase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07729","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the mitochondrial inner membrane. Evidence for one such ge... | |
medium_hidden_intermediate_07731 | Zika virus downregulates a specific gene that participates in the mitotic cell cycle. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.111 and an adjusted p-value of 0.0167. Which disease is associated with genomic alterations in this gene? | adult glioblastoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07731","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the mitotic cell cycle. In a study of glioma stem cells (GSE11... | |
medium_hidden_intermediate_07733 | In the choroid plexus epithelium, Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of TORC1 signaling. Evidence for this specific gene reports a log2 fold change of approximately 2.02 and an adjusted p-value of 0.0226. Which protein is encoded by this ... | DEP domain-containing mTOR-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07733","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the choroid plexus epithelium, Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved ... | |
medium_hidden_intermediate_07734 | Human immunodeficiency virus 1 upregulates a gene that is associated with hyperplasia. Evidence for this specific gene reports a log2 fold change of 1.274 and an adjusted p-value of 6.065e-05. Which biological process is this gene involved in? | negative regulation of cell population proliferation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07734","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with hyperplasia. Evidence for this specific gene repor... | |
medium_hidden_intermediate_07736 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and participates in disease pathology. This gene exhibits a log2 fold change of 1.411 and an adjusted p-value of 1.71e-06. Which protein is encoded by this gene? | Protein mono-ADP-ribosyltransferase PARP8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07736","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... |
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