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medium_hidden_intermediate_07737 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with USP1. One of these genes exhibits a log2 fold change of -1.513 and an adjusted p-value of 0.03962 in a specific study. Which protein is encoded by this gene? | PH domain leucine-rich repeat-containing protein phosphatase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07737","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with USP1. One of these ge... | |
medium_hidden_intermediate_07738 | Human alphaherpesvirus 1 is reported to downregulate a gene that is involved in cholesterol homeostasis. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibited a log2 fold change of -1.089 and an adjusted p-value of 0.01523. Which protein is encoded by this specific gene? | Neuronal growth regulator 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07738","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is reported to downregulate a gene that is involved in cholesterol homeostasis. In a study of monoc... | |
medium_hidden_intermediate_07740 | Zika virus upregulates a gene that is located in the mitochondrion. Evidence for this specific gene reports a log2 fold change of approximately 3.20 and an adjusted p-value of 0.003577. Which biological process is this gene involved in? | ketone body catabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07740","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is located in the mitochondrion. Evidence for this specific gene reports a log2 fold chan... | |
medium_hidden_intermediate_07741 | Zika virus infection upregulates a gene that encodes a protein with DNA-binding transcription factor activity. In a study of neural stem cells (GSE129180), one such upregulated gene exhibited a log2 fold change of approximately 2.003 and an adjusted p-value of 0.0001084. Which biological process is this specific gene i... | regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07741","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection upregulates a gene that encodes a protein with DNA-binding transcription factor activity. In a study of... | |
medium_hidden_intermediate_07742 | STRA13 and ERCC4 are connected via a two-step binding pathway involving an intermediate protein. Evidence indicates that this intermediate forms a complex with ERCC4 (also known as XPF) through a direct interaction between their binding domains, a mechanism essential for nucleotide excision repair. Which cell type is t... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07742","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"STRA13 and ERCC4 are connected via a two-step binding pathway involving an intermediate protein. Evidence indicates that thi... | |
medium_hidden_intermediate_07743 | Human alphaherpesvirus 1 upregulates a gene whose protein product is located in the centrosome. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene has a log2 fold change of approximately 2.76 and an adjusted p-value of approximately 0.0059. Which protein is encoded by this ... | Aurora kinase A- and ninein-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07743","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene whose protein product is located in the centrosome. Experimental data from a mon... | |
medium_hidden_intermediate_07744 | A gene is downregulated by Cardiovirus A and enriched in eosinophils. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.226 and an adjusted p-value of 0.01644. Which protein is encoded by this gene? | N-acetylgalactosaminyltransferase 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07744","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and enriched in eosinophils. Experimental data for this gene in a cervical adenocar... | |
medium_hidden_intermediate_07745 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to metabolic dysfunction-associated steatotic liver disease via genomic alterations. One of these genes was reported in a study (GSE148697) involving lung cells, with a log2 fold change of 1.735 and an adjusted p-value of... | X-box-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07745","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to metabolic dysfunction-... | |
medium_hidden_intermediate_07746 | Human betaherpesvirus 5 upregulates a gene that is involved in the positive regulation of cell population proliferation. Experimental data for this gene in a lung fibroblast cell line (study GSE120890) reports a log2 fold change of approximately 1.099 and an adjusted p-value of 0.002476. Which protein is encoded by thi... | C-X-C motif chemokine 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07746","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is involved in the positive regulation of cell population proliferation. Exp... | |
medium_hidden_intermediate_07747 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and participating in glycerophospholipid biosynthesis. This specific gene exhibits a log2 fold change of -1.255 and an adjusted p-value of 0.007967. Which protein is encoded by this gene? | Choline kinase alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07747","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and... | |
medium_hidden_intermediate_07748 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with XPO1. Evidence for one such gene reports a log2 fold change of 1.030 and an adjusted p-value of 0.02779. Which cellular component is that gene located in? | adherens junction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07748","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with XPO1. Evidence for one such gen... | |
medium_hidden_intermediate_07749 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in the mitotic cell cycle. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene has a log2 fold change of -1.721 and an adjusted p-value of 0.002182. Which protein is encoded by this ... | Transportin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07749","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in the mitotic cell cycle. Experimental ... | |
medium_hidden_intermediate_07750 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are upregulated by the virus and interact with KLF16. One of these genes exhibits a log2 fold change of approximately 1.184 and an adjusted p-value of 0.005048. Which protein is encoded by this specific gene? | ATP-dependent RNA helicase DDX24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07750","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are upregulated by the virus and interact with K... | |
medium_hidden_intermediate_07751 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene involved in ribosomal small subunit biogenesis. This specific gene exhibited a log2 fold change of approximately 1.28 and an adjusted p-value of 0.0082. Which protein is encoded by th... | Neuroguidin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07751","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_07752 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the extracellular matrix. Evidence for one such gene reports a log2 fold change of -1.013 and an adjusted p-value of 8.797e-05. Which disease is associated with this gene as a biomarker? | plasma cell myeloma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07752","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the extracellular matrix. Evid... | |
medium_hidden_intermediate_07753 | Zika virus is reported to downregulate a specific gene, which is in turn associated with complete hydatidiform mole. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -2.692 and an adjusted p-value of 0.006108. Which protein is encoded by this gene? | StAR-related lipid transfer protein 7, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07753","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus is reported to downregulate a specific gene, which is in turn associated with complete hydatidiform mole. In a st... | |
medium_hidden_intermediate_07755 | Two genes are structurally linked in a pathway starting from Primate bocaparvovirus 1 (via an upregulation relation) and ending at PPP1CC (via an interaction relation). One of these intermediate genes is reported in a study with a log2 fold change of approximately 1.65 and an adjusted p-value of approximately 0.027. Wh... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07755","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked in a pathway starting from Primate bocaparvovirus 1 (via an upregulation relation) and end... | |
medium_hidden_intermediate_07756 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables DNA binding. Evidence for one such gene reports a log2 fold change of -1.191 and an adjusted p-value of 0.007919. Which protein is encoded by that gene? | Transcription factor SOX-15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07756","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables DNA binding. Evidence for one such g... | |
medium_hidden_intermediate_07757 | In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are downregulated and their products interact with LAMP1. One such gene exhibits a log2 fold change of approximately -1.472 and an adjusted p-value of 0.04562. Which protein is encoded by this specific gene? | NADPH-dependent quinone oxidoreductase VAT1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07757","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are downregulated and their pro... | |
medium_hidden_intermediate_07758 | Two genes are downregulated by Human immunodeficiency virus 1 and participate in Signaling by Rho GTPases, Miro GTPases and RHOBTB3. One of these genes exhibits a log2 fold change of -2.079 and an adjusted p-value of 0.01101 in macrophages (study GSE108897). Which disease is associated with this specific gene as a biom... | bipolar disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07758","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and participate in Signaling by Rho GTPases, Miro GTPases and ... | |
medium_hidden_intermediate_07759 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for a disease. Experimental data for this gene in lung cells (study GSE148697) reports a log2 fold change of approximately -1.764 and an adjusted p-value of 0.0001449. Which protein does this gene product bind to? | ADGRB1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07759","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for a disease. Ex... | |
medium_hidden_intermediate_07762 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of specific genes that participate in gene expression (transcription). One such gene exhibits a log2 fold change of approximately -1.091 and an adjusted p-value of 0.02769. Which biological process is this specific gen... | negative regulation of DNA-templated transcription | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07762","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of specific genes that... | |
medium_hidden_intermediate_07763 | Human immunodeficiency virus 1 upregulates a gene that is involved in proteolysis. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 1.172 and an adjusted p-value of 0.0006665. Which disease is associated with this gene? | teratocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07763","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in proteolysis. Evidence for this gene in macrophages (fr... | |
medium_hidden_intermediate_07764 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to RNF8. The expression data for this intermediate gene shows a log2 fold change of -1.118 and an adjusted p-value of 0.01337. Which protein is... | Lys-63-specific deubiquitinase BRCC36 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07764","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_07766 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene involved in the defense response to virus. One such gene exhibits a log2 fold change of 3.252 and an adjusted p-value of 0.04574. Which protein is encoded by this specific gene? | Interferon-induced protein 44-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07766","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene involved in the defense respo... | |
medium_hidden_intermediate_07767 | In a study of Influenza A virus infection, a gene is upregulated by the virus and participates in sphingolipid catabolism. Evidence for this specific gene reports a log2 fold change of 1.062 and an adjusted p-value of 0.006999. Which protein is encoded by this gene? | Alkaline ceramidase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07767","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a gene is upregulated by the virus and participates in sphingolipid catabolism. E... | |
medium_hidden_intermediate_07769 | Zaire ebolavirus infection leads to the upregulation of specific genes that are enriched in conventional dendritic cells. One such gene exhibits a log2 fold change of 2.182 and an adjusted p-value of 1.853e-06 in retinal pigment epithelium cell lines (study GSE100839). Which protein is encoded by this gene? | Highly divergent homeobox | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07769","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of specific genes that are enriched in conventional dendritic cells. On... | |
medium_hidden_intermediate_07770 | Human immunodeficiency virus 1 downregulates a gene that participates in the metabolism of nucleotides. Evidence for one such gene reports a log2 fold change of -1.313 and an adjusted p-value of 0.005811. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07770","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in the metabolism of nucleotides. Evidence for one suc... | |
medium_hidden_intermediate_07772 | Pegivirus C downregulates a specific gene, which in turn interacts with STING1 (TMEM173). Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this intermediate gene has a log2 fold change of approximately -1.95 and an adjusted p-value of 0.0126. Which cellular component is this ... | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07772","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, which in turn interacts with STING1 (TMEM173). Transcriptomic data from periphera... | |
medium_hidden_intermediate_07775 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both bind to RPS27A. One of these genes exhibits a log2 fold change of -1.676 and an adjusted p-value of 9.021e-06 in lung tissue data from study GSE148697. Which disease is associated with this specific gene? | polyposis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07775","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both bind to RPS27A. One of these g... | |
medium_hidden_intermediate_07777 | Human alphaherpesvirus 3 upregulates a gene that is involved in the immune response. In a study of melanoma cell lines (GSE136586), one such upregulated gene exhibited a log2 fold change of 1.956 and an adjusted p-value of 9.369e-11. Which protein is encoded by this specific gene? | Guanylate-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07777","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that is involved in the immune response. In a study of melanoma cell lines (GSE1... | |
medium_hidden_intermediate_07778 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to the Developmental Lineage of Mammary Gland Alveolar Cells via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of appro... | Keratin, type II cytoskeletal 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07778","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_07779 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and binds to POU2F1. This gene exhibits a log2 fold change of -1.638 and an adjusted p-value of 0.001185. Which protein is encoded by this gene? | Cyclic AMP-dependent transcription factor ATF-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07779","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and binds to POU2F1. Th... | |
medium_hidden_intermediate_07781 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to NEDD8. Experimental data for this gene reports a log2 fold change of approximately 1.07 and an adjusted p-value of 0.02256. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07781","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to NEDD8. Experimental data for thi... | |
medium_hidden_intermediate_07782 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that enables UDP-xylosyltransferase activity. One such gene exhibited a log2 fold change of approximately -1.32 and an adjusted p-value of 0.0047. Which protein is encoded by this specific gene? | Glucoside xylosyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07782","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that enables UDP-xylo... | |
medium_hidden_intermediate_07783 | Two distinct drugs are known to interact with both Methotrexate and Iodide I-131. One of these drugs is associated with evidence stating: 'When these values for Ki obtained with PEN were compared to values obtained with methotrexate and p-aminohippurate, the values of Ki were similar, implying the presence of a similar... | urinary tract infection | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07783","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are known to interact with both Methotrexate and Iodide I-131. One of these drugs is associated with evid... | |
medium_hidden_intermediate_07784 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in methylation. Experimental data for this gene in a bronchial epithelial cell line (study GSE153218) shows a log2 fold change of approximately -1.35 and an adjusted p-value of 0.0083. Which protein is encoded by this gene? | Histamine N-methyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07784","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in methylation. Experimenta... | |
medium_hidden_intermediate_07786 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in cell adhesion. Experimental data for this gene reports a log2 fold change of 1.746 and an adjusted p-value of 0.01703. Which disease is associated with this gene through genomic alterations? | familial dilated cardiomyopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07786","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in cell adhesion. Experimenta... | |
medium_hidden_intermediate_07787 | Zika virus downregulates a gene that interacts with CEP135. Experimental data for this gene shows a log2 fold change of -2.830 and an adjusted p-value of 0.00257. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07787","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with CEP135. Experimental data for this gene shows a log2 fold change of -2.8... | |
medium_hidden_intermediate_07789 | In a study of cardiomyocyte cell lines (GSE151879), a gene is identified as being upregulated by Severe acute respiratory syndrome-related coronavirus and serving as a biomarker for schizophrenia. This specific gene exhibits a log2 fold change of approximately 2.41 and an adjusted p-value of approximately 0.01025. Whic... | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07789","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), a gene is identified as being upregulated by Severe acute respiratory sy... | |
medium_hidden_intermediate_07790 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in chromatin modifying enzyme activity. This gene exhibits a log2 fold change of approximately 1.95 and an adjusted p-value of approximately 1.58e-09. In which cellular component is this gene produc... | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07790","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in... | |
medium_hidden_intermediate_07791 | Human immunodeficiency virus 1 upregulates a gene that participates in extracellular matrix organization. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately 1.51 and an adjusted p-value of 0.003973. Which protein does this specific gene product bind to? | CAST | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07791","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in extracellular matrix organization. In a study of macr... | |
medium_hidden_intermediate_07792 | Measles morbillivirus upregulates a gene that enables protein kinase activator activity. Evidence for one such gene reports a log2 fold change of 1.136 and an adjusted p-value of 0.02666. Which protein is encoded by that gene? | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07792","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that enables protein kinase activator activity. Evidence for one such gene reports ... | |
medium_hidden_intermediate_07793 | Measles morbillivirus upregulates a gene that participates in the process 'PRC2 methylates histones and DNA'. Experimental data for this gene reports a log2 fold change of 1.827 and an adjusted p-value of 0.003535. Which gene interacts with the gene identified by these statistics? | TRIM24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07793","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the process 'PRC2 methylates histones and DNA'. Experimental d... | |
medium_hidden_intermediate_07794 | HSPA1A interacts with a specific protein that enables protein binding. Evidence indicates this protein interacts with other constituents of the MICOS/MIB complex and its levels are reduced upon MICOS/MIB complex depletion. Which biological process is this protein involved in? | intracellular distribution of mitochondria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07794","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"HSPA1A interacts with a specific protein that enables protein binding. Evidence indicates this protein interacts with other ... | |
medium_hidden_intermediate_07795 | Zika virus downregulates a gene that interacts with TNIP2. In glioma stem cells (study GSE114907), one such gene exhibits a log2 fold change of approximately -2.602 and an adjusted p-value of 0.01238. Which protein is encoded by this gene? | Nck-associated protein 5-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07795","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with TNIP2. In glioma stem cells (study GSE114907), one such gene exhibits a ... | |
medium_hidden_intermediate_07798 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SQSTM1. Experimental data for this gene shows a log2 fold change of 1.332 and an adjusted p-value of 0.00132. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07798","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SQSTM1. Experimental data ... | |
medium_hidden_intermediate_07799 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in peptide ligand-binding receptors. Evidence for one such gene reports a log2 fold change of 3.946 and an adjusted p-value of 7.753e-05. Which cellular component is that gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07799","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in peptide ligand-binding recepto... | |
medium_hidden_intermediate_07800 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and interacts with TCEAL1. This gene exhibits a log2 fold change of -1.567 and an adjusted p-value of 0.01155. Which protein is encoded by this gene? | Lysine-specific demethylase 3A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07800","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and interacts with TCEA... | |
medium_hidden_intermediate_07801 | In a study of lung cells (GSE148697), a gene downregulated by Severe acute respiratory syndrome-related coronavirus and involved in the adenylate cyclase-activating G protein-coupled receptor signaling pathway showed a log2 fold change of -1.676 and an adjusted p-value of 0.0002744. Which gene interacts with this speci... | RANBP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07801","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells (GSE148697), a gene downregulated by Severe acute respiratory syndrome-related coronavirus and invo... | |
medium_hidden_intermediate_07802 | In a study of glioma stem cells (GSE114907), a gene downregulated by Zika virus and known to enable spectrin binding was found to have a log2 fold change of -2.341 and an adjusted p-value of 0.03817. Which disease is associated with this specific gene? | cortical dysplasia, complex, with other brain malformations 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07802","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a gene downregulated by Zika virus and known to enable spectrin binding was fou... | |
medium_hidden_intermediate_07803 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a specific gene is upregulated by Human gammaherpesvirus 8 and associated with stroke disorder via genomic alterations. This gene exhibits a log2 fold change of 1.334 and an adjusted p-value of 0.03096. Which protein is encoded by this gene? | Cell adhesion molecule CEACAM7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07803","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a specific gene is upregulated by Human gammaherpesvirus 8 and as... | |
medium_hidden_intermediate_07804 | Pegivirus C downregulates a gene that is involved in mRNA splicing via the spliceosome. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -2.107 and an adjusted p-value of 0.01511. Which gene interacts with this specific downregulated gene? | SRRM4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07804","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that is involved in mRNA splicing via the spliceosome. In a study of peripheral blood monon... | |
medium_hidden_intermediate_07805 | Pegivirus C is reported to downregulate a gene that is located in the spindle. Evidence for this gene shows a log2 fold change of -1.230 and an adjusted p-value of 0.001266. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07805","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the spindle. Evidence for this gene shows a log2 fold chan... | |
medium_hidden_intermediate_07806 | Human alphaherpesvirus 1 upregulates a gene that is enriched in basophils. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 1.012 and an adjusted p-value of 0.005766. Which protein is encoded by this gene? | Nuclear receptor-interacting protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07806","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is enriched in basophils. Evidence for this gene in a monocytic leukemia ce... | |
medium_hidden_intermediate_07807 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Adherens junctions interactions. Experimental data for this gene reports a log2 fold change of -1.339 and an adjusted p-value of 0.01883. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07807","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Adherens junctions inte... | |
medium_hidden_intermediate_07808 | Pegivirus C is reported to downregulate a specific gene that is involved in the regulation of DNA-templated transcription. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of approximately -2.21 and an adjusted p-value of approximately 0.023. Which cellular component ... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07808","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that is involved in the regulation of DNA-templated transcription. I... | |
medium_hidden_intermediate_07810 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 is reported to downregulate a specific gene, which is involved in the negative regulation of inflammatory response. This gene exhibits a log2 fold change of approximately -1.51 and an adjusted p-value of 0.001489. Which protein is encoded by this gen... | Selenoprotein S | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07810","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 is reported to downregulate a specific gene, which is ... | |
medium_hidden_intermediate_07811 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to IGHV1-69 via a binding relationship. One of these genes exhibits a log2 fold change of approximately 1.35 and an adjusted p-value of 0.0288 in a specific study. Which protein is encoded by ... | Low affinity immunoglobulin gamma Fc region receptor II-b | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07811","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_07812 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Peptide ligand-binding receptors. Evidence for this gene reports a log2 fold change of -1.050 and an adjusted p-value of 0.04501. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07812","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Peptide ligand-binding ... | |
medium_hidden_intermediate_07813 | Two genes are upregulated by Measles morbillivirus and serve as biomarkers for glioma. One of these genes exhibits a log2 fold change of 1.768 and an adjusted p-value of 0.0009179 in pleural mesothelioma cells (study GSE117668). Which biological process is this specific gene involved in? | negative regulation of transforming growth factor beta receptor signaling pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07813","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Measles morbillivirus and serve as biomarkers for glioma. One of these genes exhibits a log2 fo... | |
medium_hidden_intermediate_07814 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with HDAC2. Transcriptomic data for this gene in choroid plexus epithelium (study GSE157852) shows a log2 fold change of approximately 1.13 and an adjusted p-value of approximately 0.0042. Which disease is associated with genom... | melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07814","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with HDAC2. Transcriptomic data... | |
medium_hidden_intermediate_07815 | Vaccinia virus upregulates a gene that interacts with SYVN1. Evidence for this gene reports a log2 fold change of 1.435 and an adjusted p-value of 2.521e-06. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07815","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that interacts with SYVN1. Evidence for this gene reports a log2 fold change of 1.435 and ... | |
medium_hidden_intermediate_07816 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to leiomyoma via association. One of these genes exhibits a log2 fold change of -3.657 and an adjusted p-value of 0.002366 in a specific study. Which protein is encoded by this gene? | Pappalysin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07816","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to leiomyoma via associ... | |
medium_hidden_intermediate_07817 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of inflammatory response. Evidence for one such gene reports a log2 fold change of 1.035 and an adjusted p-value of 0.0155. Which protein is encoded by that gene? | C-C chemokine receptor type 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07817","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of infl... | |
medium_hidden_intermediate_07818 | Eosinophils express a specific surface marker that enables protein binding. Evidence indicates that 2B4 (CD244), a member of the CD2 subset of the immunoglobulin superfamily, serves as the high-affinity ligand for this marker. Which disease is associated with genomic alterations in this marker? | systemic lupus erythematosus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07818","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Eosinophils express a specific surface marker that enables protein binding. Evidence indicates that 2B4 (CD244), a member of... | |
medium_hidden_intermediate_07820 | Rhinovirus A infection leads to the downregulation of certain genes that participate in GPCR signaling. In a study of cytotoxic T-lymphocytes (GSE106475), one such gene exhibited a log2 fold change of -2.356 and an adjusted p-value of 0.006643. Which protein is encoded by this specific gene? | Diacylglycerol kinase iota | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07820","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain genes that participate in GPCR signaling. In a study of cytoto... | |
medium_hidden_intermediate_07823 | PSMB9 is involved in a biological process that is a subtype of T cell differentiation involved in immune response. Evidence for one such process describes it as the process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell, characterized by a CD4-positive, alpha-bet... | T-helper 1 type immune response | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07823","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PSMB9 is involved in a biological process that is a subtype of T cell differentiation involved in immune response. Evidence ... | |
medium_hidden_intermediate_07824 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that subsequently interacts with YWHAB. This gene exhibited a log2 fold change of approximately 1.128 and an adjusted p-value of 0.01101. Which cellular component is this gene located in? | condensed nuclear chromosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07824","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_07827 | Two genes are upregulated by Vaccinia virus and involved in the positive regulation of DNA-templated transcription. One of these genes exhibits a log2 fold change of approximately 1.378 and an adjusted p-value of 5.53e-07 in cervical adenocarcinoma cell lines. Which cell type is enriched for this specific gene? | naive thymus-derived CD8-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07827","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and involved in the positive regulation of DNA-templated transcription. One of t... | |
medium_hidden_intermediate_07828 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables integrin binding. One such gene exhibits a log2 fold change of approximately 3.45 and an adjusted p-value of 0.00047. Which protein is encoded by this specific gene? | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07828","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables integrin binding. One ... | |
medium_hidden_intermediate_07829 | Two genes are structurally linked to Pegivirus C via a 'downregulates' relationship and to the regulation of endogenous retroelements via a 'participates in' relationship. One of these genes exhibits a log2 fold change of approximately -1.57 and an adjusted p-value of 0.045 in peripheral blood mononuclear cells. Which ... | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07829","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via a 'downregulates' relationship and to the regulation of endogenous retr... | |
medium_hidden_intermediate_07831 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific host gene, which in turn enables protein homodimerization activity. This gene exhibited a log2 fold change of approximately -1.16 and an adjusted p-value of 0.036. Which biological process is this ... | DNA cytosine deamination | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07831","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific h... | |
medium_hidden_intermediate_07832 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in cell-cell signaling. Experimental data for this gene reports a log2 fold change of -1.023 and an adjusted p-value of 0.02098. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07832","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in cell-cell signaling. Exp... | |
medium_hidden_intermediate_07833 | Zika virus downregulates a specific gene, the product of which binds to RPS10. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -2.742 and an adjusted p-value of 0.005118. Which protein is encoded by this gene? | RNA-binding protein NOB1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07833","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, the product of which binds to RPS10. In a study of glioma stem cells (GSE114907), ... | |
medium_hidden_intermediate_07836 | Human betaherpesvirus 5 is linked to SARS-CoV infections via an intermediate gene that is upregulated by the virus and participates in the infection process. One such intermediate gene exhibits a log2 fold change of 4.875 and an adjusted p-value of 0.0437 in a specific study. Which protein is encoded by this intermedia... | Z-DNA-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07836","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to SARS-CoV infections via an intermediate gene that is upregulated by the virus and parti... | |
medium_hidden_intermediate_07837 | Rhinovirus A infection is associated with the upregulation of specific genes involved in the adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. In a study of cytotoxic T-lymphocytes (GSE106475), one such gene exhibited a log2 fold change of approximately 1.808 and an adjusted p-value of 0.01535.... | G-protein coupled receptor 146 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07837","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the upregulation of specific genes involved in the adenylate cyclase-inhibiting G ... | |
medium_hidden_intermediate_07839 | In a study of lung cells (GSE148697), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which in turn interacts with CANX. This gene exhibited a log2 fold change of -1.508 and an adjusted p-value of 0.001584. Which protein is encoded by this gene? | FAD-dependent oxidoreductase domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07839","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells (GSE148697), Severe acute respiratory syndrome-related coronavirus was found to downregulate a spec... | |
medium_hidden_intermediate_07840 | Pegivirus C downregulates multiple genes that are involved in retrograde vesicle-mediated transport from the Golgi to the endoplasmic reticulum. One such gene exhibits a log2 fold change of -1.325 and an adjusted p-value of 0.004028 in peripheral blood mononuclear cells. Which protein is encoded by this specific gene? | Phosphatidylinositol transfer protein beta isoform | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07840","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates multiple genes that are involved in retrograde vesicle-mediated transport from the Golgi to the en... | |
medium_hidden_intermediate_07841 | Hepacivirus C upregulates a gene that interacts with HSP90AB1. One such gene exhibits a log2 fold change of 1.207 and an adjusted p-value of 3.923e-05 in peripheral blood mononuclear cells. Which protein is encoded by this gene? | Cysteine and histidine-rich domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07841","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that interacts with HSP90AB1. One such gene exhibits a log2 fold change of 1.207 and an adj... | |
medium_hidden_intermediate_07842 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene that enables manganese ion binding. This gene exhibited a log2 fold change of approximately -1.806 and an adjusted p-value of 0.01331. Which protein is encoded by this gene? | Xyloside xylosyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07842","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene that enables man... | |
medium_hidden_intermediate_07843 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in cell adhesion. Experimental data for this gene in bronchial epithelial cells shows a log2 fold change of approximately -1.45 and an adjusted p-value of approximately 0.022. Which disease is associated with genomic altera... | diphtheria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07843","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in cell adhesion. Experimen... | |
medium_hidden_intermediate_07846 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that participates in biological oxidations. One such gene exhibits a log2 fold change of 2.575 and an adjusted p-value of 0.003988. Which protein is encoded by this specific gene? | Glycine N-acyltransferase-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07846","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that participates in biologic... | |
medium_hidden_intermediate_07848 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in O-linked glycosylation. This specific gene exhibited a log2 fold change of -1.726 and an adjusted p-value of 0.003843. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07848","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in ... | |
medium_hidden_intermediate_07849 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene was found to be downregulated by the virus and to enable DNA-binding transcription repressor activity, RNA polymerase II-specific. This gene exhibited a log2 fold change of -1.335 and an adjusted p-value of 0.0... | Zinc finger protein 219 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07849","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene was found to b... | |
medium_hidden_intermediate_07850 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that participates in Asparagine N-linked glycosylation. This gene exhibited a log2 fold change of approximately -1.10 and an adjusted p-value of 0.0056. Which protein is encoded by this gene? | Protein transport protein Sec31B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07850","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene t... | |
medium_hidden_intermediate_07851 | Measles morbillivirus upregulates a gene that is located in the basolateral plasma membrane. Evidence for one such gene reports a log2 fold change of 1.053 and an adjusted p-value of 0.001022. Which protein interacts with this gene product? | VCP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07851","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is located in the basolateral plasma membrane. Evidence for one such gene repo... | |
medium_hidden_intermediate_07853 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to SEC13 via a 'binds' relationship. One of these genes has an associated expression profile showing a log2 fold change of -1.305 and an adjusted p-value of 0.0005442. Which biological proce... | regulation of AMPA receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07853","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_07855 | Two distinct drugs are known to interact with both Erythromycin and Calcium glubionate anhydrous. One of these drugs is mentioned in a study where bacteria, exposed to antivirals including zidovudine, the drug in question, and raltegravir, developed cross-resistance to commonly used antibiotics such as trimethoprim, te... | HIV infectious disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07855","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are known to interact with both Erythromycin and Calcium glubionate anhydrous. One of these drugs is ment... | |
medium_hidden_intermediate_07857 | Two genes are downregulated by Human immunodeficiency virus 1 and both enable protein serine/threonine kinase activity. One of these genes exhibits a log2 fold change of -1.431 and an adjusted p-value of 0.004548 in macrophages (study GSE108897). Which disease is associated with this specific gene as a biomarker? | systemic lupus erythematosus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07857","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and both enable protein serine/threonine kinase activity. One ... | |
medium_hidden_intermediate_07859 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the interconversion of nucleotide di- and triphosphates. Evidence for one such gene reports a log2 fold change of -1.239 and an adjusted p-value of 0.006315. Which protein is encoded by that gene? | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07859","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the interconversion of nucle... | |
medium_hidden_intermediate_07860 | Cardiovirus A upregulates a gene that is located in the plasma membrane. In a study of cervical adenocarcinoma cell lines (GSE122967), one such upregulated gene exhibits a log2 fold change of 2.121 and an adjusted p-value of 0.008743. Which protein is encoded by this specific gene? | Ammonium transporter Rh type C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07860","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that is located in the plasma membrane. In a study of cervical adenocarcinoma cell lines (G... | |
medium_hidden_intermediate_07861 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of the apoptotic process. One of these genes was reported in a study of bronchial epithelial cells with a log2 fold change of approximately 1.31 and an adjusted p-value of approximately 0.031. ... | hyperplasia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07861","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulati... | |
medium_hidden_intermediate_07863 | A gene is downregulated by Primate bocaparvovirus 1 and is enriched in intermediate monocytes. Experimental data for this gene reports a log2 fold change of -1.982 and an adjusted p-value of 0.01217. Which protein is encoded by this gene? | DNA damage-regulated autophagy modulator protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07863","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is enriched in intermediate monocytes. Experimental data for this ge... | |
medium_hidden_intermediate_07864 | Two genes are downregulated by Human immunodeficiency virus 1 and participate in tRNA modification in the nucleus and cytosol. One of these genes exhibits a log2 fold change of -1.140 and an adjusted p-value of 0.02869 in macrophages (study GSE108897). Which disease is associated with this specific gene? | intellectual developmental disorder, autosomal recessive 82 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07864","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and participate in tRNA modification in the nucleus and cytoso... | |
medium_hidden_intermediate_07868 | Human immunodeficiency virus 1 downregulates a gene that participates in the epigenetic regulation of gene expression. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.294 and an adjusted p-value of 0.008762. Which protein is encoded by this gene? | Zinc finger protein 547 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07868","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in the epigenetic regulation of gene expression. In a ... | |
medium_hidden_intermediate_07869 | Human betaherpesvirus 5 is reported to upregulate a gene that is associated with adenoviridae infectious disease. In a study using foreskin fibroblast cell lines, this gene exhibited a log2 fold change of 3.664 and an adjusted p-value of 0.02313. Which protein is encoded by this gene? | Serpin B4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07869","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is associated with adenoviridae infectious disease. In a study... | |
medium_hidden_intermediate_07870 | Measles morbillivirus upregulates a gene that interacts with JMJD6. Experimental data for one such gene reports a log2 fold change of approximately 3.03 and an adjusted p-value of 0.00023. Which protein is encoded by this gene? | Cell division cycle-associated protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07870","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with JMJD6. Experimental data for one such gene reports a log2 fold ... | |
medium_hidden_intermediate_07871 | Zika virus downregulates a gene that participates in triglyceride metabolism. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.835 and an adjusted p-value of 0.003989. Which protein is encoded by this gene? | Phosphatidate phosphatase LPIN3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07871","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in triglyceride metabolism. In a study of glioma stem cells (GSE114907), o... | |
medium_hidden_intermediate_07872 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in phospholipid metabolism. One such gene exhibited a log2 fold change of approximately 1.76 and an adjusted p-value of 0.0001297. Which protein is encoded by this specific gene? | Lysophosphatidic acid phosphatase type 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07872","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene involve... |
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