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medium_hidden_intermediate_07873 | Pegivirus C is reported to downregulate a gene that is located in the nuclear pore nuclear basket. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of -1.767 and an adjusted p-value of 0.03823. Which protein is encoded by this specific gene? | PCI domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07873","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the nuclear pore nuclear basket. In a study of peripheral ... | |
medium_hidden_intermediate_07874 | In a study of Measles morbillivirus infection, two genes are identified as being downregulated by the virus and participating in Smooth Muscle Contraction. One of these genes exhibits a log2 fold change of -1.099 and an adjusted p-value of 0.000608. Which protein is encoded by this specific gene? | Leiomodin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07874","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being downregulated by the virus and participatin... | |
medium_hidden_intermediate_07875 | A gene is upregulated by Measles morbillivirus and enables GTPase activator activity. In a study of pleural mesothelioma cells (GSE117668), this gene exhibits a log2 fold change of approximately 2.21 and an adjusted p-value of 0.0001136. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07875","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and enables GTPase activator activity. In a study of pleural mesothelioma cel... | |
medium_hidden_intermediate_07876 | Zika virus downregulates a gene that enables ubiquitin-protein transferase activity. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -1.71 and an adjusted p-value of approximately 0.0137. Which disease is associated with this specific gene? | Malignant tumor of esophagus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07876","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables ubiquitin-protein transferase activity. In a study of glioma stem cells (GSE114... | |
medium_hidden_intermediate_07877 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that subsequently interacts with CANX. One such gene exhibits a log2 fold change of -1.708 and an adjusted p-value of 0.01078. Which protein is encoded by this specific gene? | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07877","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that subsequently interacts with ... | |
medium_hidden_intermediate_07879 | Codeine and Ketoconazole are both known to interact with a specific intermediate drug. Evidence indicates that this intermediate drug's plasma concentrations increase and its metabolites decrease in huCYP3A-PXR rats when co-administered with ketoconazole, a CYP3A4 inhibitor, regardless of rifampicin pretreatment. Which... | insomnia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07879","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Codeine and Ketoconazole are both known to interact with a specific intermediate drug. Evidence indicates that this intermed... | |
medium_hidden_intermediate_07880 | Two genes are upregulated by Hepacivirus C and participate in Signaling by Rho GTPases, Miro GTPases and RHOBTB3. One of these genes shows a log2 fold change of 1.309 and an adjusted p-value of 0.02778 in a specific study. Which disease is associated with this gene? | Aarskog-Scott syndrome, X-linked | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07880","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Hepacivirus C and participate in Signaling by Rho GTPases, Miro GTPases and RHOBTB3. One of the... | |
medium_hidden_intermediate_07881 | Pegivirus C downregulates a specific gene, which in turn binds to SNAPC5. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) reports a log2 fold change of -1.461 and an adjusted p-value of 0.04853. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07881","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, which in turn binds to SNAPC5. Experimental data for this intermediate gene in pe... | |
medium_hidden_intermediate_07882 | Human immunodeficiency virus 1 downregulates a gene that is involved in nervous system development. In a study of macrophages (GSE108897), one such gene exhibits a log2 fold change of -1.766 and an adjusted p-value of 0.004742. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07882","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in nervous system development. In a study of macrophage... | |
medium_hidden_intermediate_07883 | Measles morbillivirus downregulates a gene that is located in the extracellular region. Evidence for this specific gene reports a log2 fold change of -1.948 and an adjusted p-value of 0.04895. Which gene interacts with this downregulated gene? | PLAAT4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07883","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that is located in the extracellular region. Evidence for this specific gene repo... | |
medium_hidden_intermediate_07885 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in protein maturation. Evidence for this gene reports a log2 fold change of approximately -1.12 and an adjusted p-value of approximately 0.043. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07885","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in protein maturation. Evid... | |
medium_hidden_intermediate_07886 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene located in the endoplasmic reticulum membrane. One such gene exhibits a log2 fold change of approximately -1.108 and an adjusted p-value of 0.005077. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07886","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene located in the endoplasmic reticu... | |
medium_hidden_intermediate_07887 | Two distinct proteins are known to bind CDC42 and participate in the pathway 'Signaling by Rho GTPases, Miro GTPases and RHOBTB3'. Experimental evidence specifically verifies that CEP2 and a second protein bind Cdc42. Which molecular function is enabled by the protein identified in this evidence? | small GTPase binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07887","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct proteins are known to bind CDC42 and participate in the pathway 'Signaling by Rho GTPases, Miro GTPases and RHO... | |
medium_hidden_intermediate_07888 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that subsequently interacts with TRIM37. One such gene exhibited a log2 fold change of 1.072 and an adjusted p-value of 2.549e-05. Which protein is encoded by this specific gene? | Centrobin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07888","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upre... | |
medium_hidden_intermediate_07892 | Human immunodeficiency virus 1 downregulates a gene that participates in cell junction organization. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.485 and an adjusted p-value of 0.0225. Which biological process is this gene involved in? | protein localization to kinetochore | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07892","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in cell junction organization. In a study of macrophag... | |
medium_hidden_intermediate_07893 | Zika virus downregulates a gene that participates in protein hydroxylation. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.373 and an adjusted p-value of 0.00678. Which protein does this specific gene bind to? | ZC3H15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07893","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in protein hydroxylation. In a study of glioma stem cells (GSE114907), one... | |
medium_hidden_intermediate_07894 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to GNB1 via a binding relationship. One of these genes was reported in a study of choroid plexus epithelium (GSE157852) with a log2 fold change of approximately 1.422 and an adjusted p-value o... | gastric adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07894","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_07897 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the negative regulation of cell population proliferation. One of these genes exhibits a log2 fold change of approximately 1.97 and an adjusted p-value of 0.03543 in a specific study. Which cellular component is the lo... | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07897","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the negative regulati... | |
medium_hidden_intermediate_07899 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and its product is located in the endoplasmic reticulum. This gene exhibits a log2 fold change of 2.242 and an adjusted p-value of 1.114e-14. Which protein is encoded by this gene? | Calmegin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07899","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_07900 | Enterovirus A upregulates a gene that is involved in lipid transport. Experimental data for this gene in rhabdomyosarcoma cells shows a log2 fold change of approximately 1.62 and an adjusted p-value of 0.0006261. Which protein is encoded by this gene? | Choline kinase alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07900","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that is involved in lipid transport. Experimental data for this gene in rhabdomyosarcoma ce... | |
medium_hidden_intermediate_07901 | Two genes are upregulated by Enterovirus A and are located in the Cajal body. One of these genes shows a log2 fold change of approximately 1.129 and an adjusted p-value of 0.0007972 in rhabdomyosarcoma cells. Which disease is associated with genomic alterations in this specific gene? | cardiomyopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07901","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and are located in the Cajal body. One of these genes shows a log2 fold change of... | |
medium_hidden_intermediate_07904 | A gene is downregulated by Primate bocaparvovirus 1 and participates in the Cell Cycle. Experimental evidence for this gene reports a log2 fold change of -1.306 and an adjusted p-value of 0.01854. Which protein is encoded by this gene? | Centromere protein N | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07904","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in the Cell Cycle. Experimental evidence for this gene ... | |
medium_hidden_intermediate_07906 | Hepacivirus C downregulates a gene that is located in the centrosome. Evidence for one such gene reports a log2 fold change of -1.167 and an adjusted p-value of 0.01905. Which molecular function is enabled by that gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07906","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that is located in the centrosome. Evidence for one such gene reports a log2 fold change ... | |
medium_hidden_intermediate_07907 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with YWHAB. This gene exhibits a log2 fold change of approximately -1.383 and an adjusted p-value of 0.01234. Which protein is encoded by this downregulated gene? | R3H domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07907","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_07909 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the synaptic vesicle. Evidence for one such gene reports a log2 fold change of -1.204 and an adjusted p-value of 0.014. Which protein is encoded by that gene? | Tumor protein p63-regulated gene 1-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07909","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the synaptic vesicle. Evidence... | |
medium_hidden_intermediate_07913 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that participate in the metabolism of amino acids and derivatives. One such gene exhibited a log2 fold change of 2.738 and an adjusted p-value of 8.76e-10. Which gene interacts with this specific ... | TSC22D4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07913","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_07916 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in the negative regulation of cytochrome c release from mitochondria. This specific gene exhibited a log2 fold change of 1.557 and an adjusted p-value of 4.558e-10. Which protein is encoded by t... | Growth hormone-inducible transmembrane protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07916","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene involve... | |
medium_hidden_intermediate_07918 | Hepacivirus C is reported to downregulate a gene that subsequently binds to CTNNB1. Experimental data for one such gene shows a log2 fold change of approximately -1.91 and an adjusted p-value of 0.0031. Which protein is encoded by this specific gene? | Cadherin-17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07918","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that subsequently binds to CTNNB1. Experimental data for one such gene show... | |
medium_hidden_intermediate_07919 | Hepacivirus C upregulates a gene that participates in the biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and its transfer to a nascent protein. Evidence for this gene reports a log2 fold change of approximately 1.004 and an adjusted p-value of 0.01478. In which cell type is this gen... | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07919","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the biosynthesis of the N-glycan precursor (dolichol lipid-linked olig... | |
medium_hidden_intermediate_07921 | A gene is upregulated by Primate bocaparvovirus 1 and is involved in the apoptotic process. Experimental evidence for this gene reports a log2 fold change of 2.557 and an adjusted p-value of 0.02756. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07921","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is involved in the apoptotic process. Experimental evidence for this g... | |
medium_hidden_intermediate_07923 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to RNA polymerase II cis-regulatory region sequence-specific DNA binding via an 'enables' relationship. One of these genes has an associated expression profile in macrophages (from study GSE108897) showing a log2 ... | leprosy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07923","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to RNA polymerase... | |
medium_hidden_intermediate_07926 | Two genes are linked to Vaccinia virus via upregulation and to diabetes mellitus as biomarkers. One of these genes exhibits a log2 fold change of 2.753 and an adjusted p-value of 3.474e-07 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is encoded by the gene matching these statistical values? | Kallikrein-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07926","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Vaccinia virus via upregulation and to diabetes mellitus as biomarkers. One of these genes exhibits ... | |
medium_hidden_intermediate_07927 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of immune response. Evidence for one such gene reports a log2 fold change of 1.137 and an adjusted p-value of 0.009989. Which protein is encoded by that gene? | WD repeat-containing protein 41 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07927","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of immu... | |
medium_hidden_intermediate_07930 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Keratan sulfate degradation. Evidence for this gene reports a log2 fold change of -1.079 and an adjusted p-value of 0.006595. Which molecular function is enabled by this gene? | extracellular matrix structural constituent conferring compression resistance | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07930","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Keratan sulfate degrada... | |
medium_hidden_intermediate_07931 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of specific genes whose protein products are located in the early endosome membrane. One such gene exhibits a log2 fold change of -1.502 and an adjusted p-value of 0.001592. Which protein is encoded by this spec... | 1-phosphatidylinositol 3-phosphate 5-kinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07931","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of specific gen... | |
medium_hidden_intermediate_07932 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with AURKA. This specific gene exhibits a log2 fold change of approximately 2.02 and an adjusted p-value of approximately 5.64e-05. Which protein is encoded by this gene? | Obg-like ATPase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07932","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with AURK... | |
medium_hidden_intermediate_07933 | Two histone genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to the process 'PRC2 methylates histones and DNA' via a 'participates in' relationship. One of these genes exhibits a log2 fold change of -1.564 and an adjusted p-value of 0.0412 in macrophages (study GSE1... | digestive system neuroendocrine tumor, grade 1/2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07933","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two histone genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to the pr... | |
medium_hidden_intermediate_07936 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in the synthesis of PIPs at the plasma membrane. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) show a log2 fold change of approximately -1.031 and an adjusted p-value of 0.005202. Which dis... | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07936","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in the synthesis of PIPs at the plasma m... | |
medium_hidden_intermediate_07937 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of specific genes. One such gene, which is involved in ribosomal large subunit biogenesis, exhibits a log2 fold change of -3.828 and an adjusted p-value of 0.00257. Which protein interacts with this specific gene product? | CUL3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07937","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of specific genes. One such ge... | |
medium_hidden_intermediate_07940 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with NCOR1. Experimental data for this intermediate gene shows a log2 fold change of approximately -1.37 and an adjusted p-value of 0.001033. In which cell type is this intermediate gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07940","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with NCOR1. Experimental data for this inte... | |
medium_hidden_intermediate_07943 | Hepacivirus C is reported to downregulate a specific gene that participates in post-translational protein modification. In a study of hepatocytes (GSE132606), this gene exhibited a log2 fold change of approximately -1.05 and an adjusted p-value of 0.022. Which disease is associated with this gene as a biomarker? | adult fibrosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07943","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene that participates in post-translational protein modification. In a... | |
medium_hidden_intermediate_07944 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and involved in the positive regulation of transcription by RNA polymerase II. This gene exhibits a log2 fold change of approximately 1.144 and an adjusted p-value of 8.467e-08. Which protein is encode... | Cyclic AMP-dependent transcription factor ATF-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07944","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_07945 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and associated with adenoviridae infectious disease. This gene exhibits a log2 fold change of approximately -1.29 and an adjusted p-value of approximately 0.0076. Which protein is encoded by this gene? | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07945","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and associated with ade... | |
medium_hidden_intermediate_07946 | A gene is downregulated by Primate bocaparvovirus 1 and is associated with carcinoma. Experimental data for this gene in umbilical vein endothelial cells (study GSE119608) reports a log2 fold change of approximately -1.254 and an adjusted p-value of 0.04848. Which cellular component is this gene located in? | Golgi membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07946","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is associated with carcinoma. Experimental data for this gene in umb... | |
medium_hidden_intermediate_07947 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to arteriosclerosis disorder via biomarker association. One of these genes exhibits a log2 fold change of -1.416 and an adjusted p-value of 4.402e-06 in a specific study. Which protein is encoded by this gene? | Perilipin-5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07947","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to arteriosclerosis dis... | |
medium_hidden_intermediate_07948 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in O-linked glycosylation. Experimental data for this gene reports a log2 fold change of 5.121 and an adjusted p-value of 0.04913. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07948","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in O-linked glycosylation. E... | |
medium_hidden_intermediate_07950 | Hepacivirus C is reported to downregulate a gene that enables sequence-specific DNA binding. Experimental data for one such gene shows a log2 fold change of -2.564 and an adjusted p-value of 0.005347. Which protein is encoded by this gene? | SAM pointed domain-containing Ets transcription factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07950","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables sequence-specific DNA binding. Experimental data for one such ... | |
medium_hidden_intermediate_07951 | Two genes are structurally linked from Cardiovirus A via an 'upregulates' relationship and subsequently to Neutrophil via an 'enriched in' relationship. One of these genes has a reported log2 fold change of 1.481 and an adjusted p-value of 0.008743 in a specific study context. Which disease is associated with this spec... | congestive heart failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07951","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Cardiovirus A via an 'upregulates' relationship and subsequently to Neutrophil via an... | |
medium_hidden_intermediate_07952 | Zika virus downregulates a gene that interacts with HRAS. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -1.41 and an adjusted p-value of 0.0193. Which protein is encoded by this specific gene? | Ras association domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07952","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with HRAS. In a study of glioma stem cells (GSE114907), one such gene exhibit... | |
medium_hidden_intermediate_07954 | Zika virus downregulates a gene that participates in gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation. In glioma stem cells, one such gene exhibits a log2 fold change of -1.912 and an adjusted p-value of 0.01082. Which protein is encoded by this gene? | Ribosomal oxygenase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07954","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase a... | |
medium_hidden_intermediate_07956 | EP300 interacts with a transcription factor that is associated with carcinoma of supraglottis. Evidence for this interaction indicates that binding between purified proteins demonstrated a direct interaction. Which protein is encoded by this transcription factor? | Protein C-ets-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07956","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"EP300 interacts with a transcription factor that is associated with carcinoma of supraglottis. Evidence for this interaction... | |
medium_hidden_intermediate_07957 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes located in the cytoplasm. One such gene exhibits a log2 fold change of -1.259 and an adjusted p-value of 0.01576. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07957","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes locat... | |
medium_hidden_intermediate_07958 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the formation of the cornified envelope. Evidence for this gene reports a log2 fold change of -1.092 and an adjusted p-value of 0.004011. Which disease is connected to this gene through genomic alterations? | hypertensive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07958","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the formation of the co... | |
medium_hidden_intermediate_07960 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene upregulated by Human gammaherpesvirus 8 and located in the extracellular space was found to have a log2 fold change of 3.525 and an adjusted p-value of 0.002692. Which protein does this specific gene product interact with? | KEAP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07960","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene upregulated by Human gammaherpesvirus 8 and located in the... | |
medium_hidden_intermediate_07961 | Hepacivirus C infection leads to the downregulation of certain genes located in the lysosomal membrane. One such gene exhibits a log2 fold change of approximately -1.176 and an adjusted p-value of 0.009299 in hepatocytes. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07961","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C infection leads to the downregulation of certain genes located in the lysosomal membrane. One such gene exhibi... | |
medium_hidden_intermediate_07962 | Pegivirus C is reported to downregulate a gene that is associated with infectious mononucleosis. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibits a log2 fold change of approximately -1.335 and an adjusted p-value of 0.008273. Which protein is encoded by this specific gene? | Beta-1,4 N-acetylgalactosaminyltransferase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07962","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is associated with infectious mononucleosis. In a study of peripheral bl... | |
medium_hidden_intermediate_07963 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that participates in Signaling by NOTCH. This gene exhibited a log2 fold change of -2.033 and an adjusted p-value of 0.03889. Which protein is encoded by this gene? | Notch homolog 2 N-terminal-like protein A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07963","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_07964 | Pegivirus C is known to downregulate certain genes that enable zinc ion binding. One such gene exhibits a log2 fold change of -1.517 and an adjusted p-value of 0.001483 in peripheral blood mononuclear cells. Which cell type is this specific gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07964","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is known to downregulate certain genes that enable zinc ion binding. One such gene exhibits a log2 fold change o... | |
medium_hidden_intermediate_07965 | Two genes are upregulated by Vaccinia virus and both bind to MRPS18B. One of these genes exhibits a log2 fold change of 4.237 and an adjusted p-value of 3.429e-07 in cervical adenocarcinoma cell lines (study GSE11238). Which disease is associated with this specific gene? | combined oxidative phosphorylation deficiency 45 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07965","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and both bind to MRPS18B. One of these genes exhibits a log2 fold change of 4.23... | |
medium_hidden_intermediate_07966 | Human immunodeficiency virus 1 upregulates a gene that participates in Signaling by Rho GTPases. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of 2.107 and an adjusted p-value of 0.001771. Which protein is encoded by this gene? | StAR-related lipid transfer protein 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07966","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in Signaling by Rho GTPases. In a study of macrophages (... | |
medium_hidden_intermediate_07967 | Hepacivirus C is linked to IGKV1-39 via an intermediate gene that is upregulated by the virus and binds to IGKV1-39. One such intermediate gene exhibits a log2 fold change of 1.285 and an adjusted p-value of 0.01786 in a specific study. Which protein is encoded by this intermediate gene? | Complement C1q subcomponent subunit A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07967","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is linked to IGKV1-39 via an intermediate gene that is upregulated by the virus and binds to IGKV1-39. One suc... | |
medium_hidden_intermediate_07968 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in extracellular matrix organization. Evidence for this gene reports a log2 fold change of approximately 1.097 and an adjusted p-value of 0.01715. Which biological process is this gene involved in? | proteolysis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07968","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in extracellular... | |
medium_hidden_intermediate_07970 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that participates in Class A/1 (Rhodopsin-like receptors). This gene exhibited a log2 fold change of -1.458 and an adjusted p-value of 0.03023. Which protein is encoded by this gene? | Cysteinyl leukotriene receptor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07970","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_07971 | Enterovirus A upregulates a gene that is located in the endoplasmic reticulum membrane. Evidence for this gene in rhabdomyosarcoma cells reports a log2 fold change of approximately 1.346 and an adjusted p-value of approximately 0.01069. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07971","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that is located in the endoplasmic reticulum membrane. Evidence for this gene in rhabdomyos... | |
medium_hidden_intermediate_07972 | Two genes are downregulated by Pegivirus C and participate in SARS-CoV infections. One of these genes exhibits a log2 fold change of -1.491 and an adjusted p-value of 0.0008057 in peripheral blood mononuclear cells (study GSE131504). Which disease is associated with this specific gene? | Rafiq syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07972","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and participate in SARS-CoV infections. One of these genes exhibits a log2 fold c... | |
medium_hidden_intermediate_07973 | Zaire ebolavirus infection leads to the upregulation of certain genes that are enriched in natural killer cells. One such gene exhibits a log2 fold change of 2.029 and an adjusted p-value of 0.04107 in retinal pigment epithelium cells. Which protein is encoded by this specific gene? | Nucleosome assembly protein 1-like 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07973","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of certain genes that are enriched in natural killer cells. One such ge... | |
medium_hidden_intermediate_07975 | TLCD2 is involved in a biological process that is a type of membrane organization. One such process is defined by the aggregation, arrangement, and bonding together of a set of components to form a membrane. Which biological process is this specific entity a part of? | membrane biogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07975","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"TLCD2 is involved in a biological process that is a type of membrane organization. One such process is defined by the aggreg... | |
medium_hidden_intermediate_07978 | Hepacivirus C is associated with the downregulation of a specific gene, which is in turn enriched in memory B cells. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE119117) reports a log2 fold change of approximately -2.007 and an adjusted p-value of approximately 0.0008114. Which p... | EF-hand calcium-binding domain-containing protein 4A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07978","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a specific gene, which is in turn enriched in memory B cells. Experim... | |
medium_hidden_intermediate_07981 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with hyperplasia. Experimental data for this gene reports a log2 fold change of 1.015 and an adjusted p-value of 0.0255. Which protein is encoded by this gene? | Inhibitor of growth protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07981","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with hyperplasia. Experimen... | |
medium_hidden_intermediate_07982 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequently interacts with ATM. Evidence for this gene reports a log2 fold change of 1.919 and an adjusted p-value of 0.005653. Which protein is encoded by this gene? | Eukaryotic translation initiation factor 4E-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07982","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequent... | |
medium_hidden_intermediate_07984 | Human immunodeficiency virus 1 downregulates a gene that enables guanyl-nucleotide exchange factor activity. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -2.229 and an adjusted p-value of 0.03699. Which protein is encoded by this specific gene? | DENN domain-containing protein 2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07984","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that enables guanyl-nucleotide exchange factor activity. In a study of m... | |
medium_hidden_intermediate_07985 | Zika virus downregulates a gene that is located in the focal adhesion. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -2.619 and an adjusted p-value of 0.007589. Which protein does this gene product bind to? | RND2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07985","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the focal adhesion. In a study of glioma stem cells (GSE114907), this gen... | |
medium_hidden_intermediate_07987 | Two genes are downregulated by Pegivirus C and both enable zinc ion binding. One of these genes has a reported log2 fold change of -1.108 and an adjusted p-value of 0.009386 in peripheral blood mononuclear cells. Which protein interacts with this specific gene product? | RBM10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07987","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and both enable zinc ion binding. One of these genes has a reported log2 fold cha... | |
medium_hidden_intermediate_07988 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn encodes a protein that binds to GNAI1. The expression data for this gene shows a log2 fold change of approximately 3.55 and an adjusted p-value of 2.901e-05. Which protein is enco... | C-C chemokine receptor type 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07988","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_07990 | Enterovirus A is reported to downregulate a specific gene that is involved in proteolysis. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) indicate a log2 fold change of approximately -1.82 and an adjusted p-value of approximately 0.026. Which disease is associated with this gene as a biomar... | skin cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07990","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene that is involved in proteolysis. Experimental data for this gene i... | |
medium_hidden_intermediate_07991 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with TP53. This specific gene exhibits a log2 fold change of 4.404 and an adjusted p-value of 0.002548. Which protein is encoded by this gene? | E3 ubiquitin ligase RNF157 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07991","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with TP53... | |
medium_hidden_intermediate_07992 | Enterovirus A upregulates a specific gene that is involved in intracellular signal transduction. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately 4.06 and an adjusted p-value of approximately 0.023. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07992","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a specific gene that is involved in intracellular signal transduction. Experimental data for this ... | |
medium_hidden_intermediate_07993 | Two genes are upregulated by Human immunodeficiency virus 1 and associated with glioma. One of these genes exhibits a log2 fold change of 8.205 and an adjusted p-value of 2.929e-05 in macrophages (study GSE108897). Which biological process is this specific gene involved in? | chemical synaptic transmission | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07993","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and associated with glioma. One of these genes exhibits a log2 f... | |
medium_hidden_intermediate_07994 | In a study of bronchial epithelial cells (GSE147507), Influenza A virus infection leads to the downregulation of certain genes that participate in the Generic Transcription Pathway. One such gene exhibits a log2 fold change of -1.543 and an adjusted p-value of 4.072e-07. What molecular function is enabled by this speci... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07994","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells (GSE147507), Influenza A virus infection leads to the downregulation of certain gen... | |
medium_hidden_intermediate_07996 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and its transfer to a nascent protein. Evidence for one such gene reports a log2 fold change of 3.601 and an adjusted p-value of 0.03845. ... | Alpha-2,8-sialyltransferase 8E | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07996","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the biosynthesis of the N-glyc... | |
medium_hidden_intermediate_07997 | Pegivirus C downregulates a gene that participates in Complex IV assembly. Evidence from a study on peripheral blood mononuclear cells (GSE131504) reports that this gene has a log2 fold change of approximately -1.445 and an adjusted p-value of 0.01045. Which molecular function is enabled by this gene? | protein folding chaperone | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07997","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in Complex IV assembly. Evidence from a study on peripheral blood mononuc... | |
medium_hidden_intermediate_08001 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to the antimicrobial humoral immune response mediated by antimicrobial peptide via an 'involved in' relationship. One of these genes is associated with experimental data showing a log2 fold ... | CXCR4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08001","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_08003 | Zaire ebolavirus downregulates a gene that is located in the plasma membrane. In a study of retinal pigment epithelium cells (GSE100839), one such gene exhibited a log2 fold change of approximately -1.13 and an adjusted p-value of 0.00115. Which protein is encoded by this specific gene? | Carabin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08003","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that is located in the plasma membrane. In a study of retinal pigment epithelium cells... | |
medium_hidden_intermediate_08005 | Human betaherpesvirus 5 upregulates a gene that participates in post-translational protein modification. In a study of foreskin fibroblast cell lines (GSE130665), one such upregulated gene showed a log2 fold change of 1.186 and an adjusted p-value of 0.0005056. Which protein is encoded by this specific gene? | Histone H2B type 1-C/E/F/G/I | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08005","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in post-translational protein modification. In a study of fores... | |
medium_hidden_intermediate_08006 | Two genes are structurally linked to Hepacivirus C via a 'downregulates' relationship and to zinc ion binding via an 'enables' relationship. One of these genes has been reported in a study (GSE132606) with a log2 fold change of -1.106 and an adjusted p-value of 0.0375. Which disease is associated with this specific gen... | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08006","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Hepacivirus C via a 'downregulates' relationship and to zinc ion binding via an 'enable... | |
medium_hidden_intermediate_08008 | Zika virus downregulates a specific gene, which in turn interacts with TRAF6. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -4.08 and an adjusted p-value of 0.0422. Which protein is encoded by this gene? | Ubiquitin carboxyl-terminal hydrolase 20 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08008","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with TRAF6. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_08009 | Cardiovirus A downregulates a specific gene that is involved in the positive regulation of cell population proliferation. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately -2.000 and an adjusted p-value of 0.01243. Which cell type is thi... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08009","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a specific gene that is involved in the positive regulation of cell population proliferation. Ex... | |
medium_hidden_intermediate_08010 | Vaccinia virus upregulates a gene that enables DNA-binding transcription factor activity. Evidence for one such gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 1.64 and an adjusted p-value of 0.0225. Which disease is associated with this gene as a biomarker? | malignant glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08010","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that enables DNA-binding transcription factor activity. Evidence for one such gene in a ce... | |
medium_hidden_intermediate_08011 | Zika virus downregulates a gene that interacts with LIN28A. In glioma stem cells, one such gene exhibits a log2 fold change of -3.807 and an adjusted p-value of 0.005849. Which protein is encoded by this gene? | RRP12-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08011","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with LIN28A. In glioma stem cells, one such gene exhibits a log2 fold change ... | |
medium_hidden_intermediate_08012 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Neddylation. Experimental data for this gene reports a log2 fold change of 1.190 and an adjusted p-value of 0.00602. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08012","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Neddylation. Experimental... | |
medium_hidden_intermediate_08015 | KCNA5 is involved in a biological process that is a type of membrane repolarization during cardiac muscle cell action potential. One such process is defined as the process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action p... | SA node cell action potential | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08015","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"KCNA5 is involved in a biological process that is a type of membrane repolarization during cardiac muscle cell action potent... | |
medium_hidden_intermediate_08016 | Two genes are downregulated by Influenza A virus and associated with invasive breast carcinoma. One of these genes exhibits a log2 fold change of -1.064 and an adjusted p-value of 1.678e-05 in a specific study. Which disease is linked to this specific gene via a biomarker relationship? | acute myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08016","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Influenza A virus and associated with invasive breast carcinoma. One of these genes exhibits ... | |
medium_hidden_intermediate_08017 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the fructose metabolic process. Evidence for one such gene reports a log2 fold change of 1.726 and an adjusted p-value of 6.243e-05. Which protein is encoded by that gene? | Fructose-1,6-bisphosphatase isozyme 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08017","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the fructose metabolic process.... | |
medium_hidden_intermediate_08019 | A gene is upregulated by Primate bocaparvovirus 1 and associated with liver cancer through genomic alterations. Evidence for this gene reports a log2 fold change of 10.955 and an adjusted p-value of 0.02685. Which protein is encoded by this gene? | Interferon lambda-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08019","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and associated with liver cancer through genomic alterations. Evidence for... | |
medium_hidden_intermediate_08021 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Biological oxidations. Experimental data for this gene shows a log2 fold change of -1.151 and an adjusted p-value of 0.01466. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08021","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Biological oxidations. ... | |
medium_hidden_intermediate_08022 | Two genes are upregulated by Vaccinia virus and interact with CCNF. One of these genes shows a log2 fold change of 2.601 and an adjusted p-value of 2.106e-13 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene as a biomarker? | heart failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08022","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with CCNF. One of these genes shows a log2 fold change of 2.601 and... | |
medium_hidden_intermediate_08023 | COBLL1 and WASL are linked by a two-step interaction pathway involving an intermediate protein. Evidence indicates that this intermediate protein's isoforms potentially oligomerize and bind to dynamin, synaptojanin 1, and N-WASP via their Src homology 3 domains. Which protein is encoded by the gene corresponding to thi... | Protein kinase C and casein kinase substrate in neurons protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08023","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"COBLL1 and WASL are linked by a two-step interaction pathway involving an intermediate protein. Evidence indicates that this... | |
medium_hidden_intermediate_08024 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene that participates in the metabolism of amino acids and derivatives. This gene exhibited a log2 fold change of approximately -1.64 and an adjusted p-value of 0.000386. Whic... | TPI1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08024","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_08025 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the CDC42 GTPase cycle. One of these genes exhibits a log2 fold change of -1.117 and an adjusted p-value of 0.0499 in bronchial epithelial cells. Which disease is associated with this specific gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08025","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the CDC42 GTPase cyc... | |
medium_hidden_intermediate_08028 | Measles morbillivirus upregulates a gene that enables transcription corepressor activity. Evidence for one such gene reports a log2 fold change of 1.096 and an adjusted p-value of 0.004924. Which cellular component is this gene located in? | chromatin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08028","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that enables transcription corepressor activity. Evidence for one such gene reports... |
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