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medium_hidden_intermediate_08029 | Two genes are structurally linked from Measles morbillivirus via an 'upregulates' relationship and to intermediate monocytes via an 'enriched in' relationship. One of these genes has reported expression data showing a log2 fold change of approximately 1.45 and an adjusted p-value of approximately 0.0102. Which protein ... | Phospholipid scramblase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08029","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Measles morbillivirus via an 'upregulates' relationship and to intermediate monocytes... | |
medium_hidden_intermediate_08030 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with MAPK1. Evidence for one such gene reports a log2 fold change of 1.097 and an adjusted p-value of 0.007719. Which protein is encoded by that gene? | Zinc finger C3HC-type protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08030","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with MAPK1. Evidence for one such ge... | |
medium_hidden_intermediate_08031 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participates in the CDC42 GTPase cycle. Evidence for this gene reports a log2 fold change of approximately 1.39 and an adjusted p-value of approximately 0.037. Which protein is encoded by this gene? | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08031","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participate... | |
medium_hidden_intermediate_08032 | Human immunodeficiency virus 1 upregulates a gene that is located in the lysosomal membrane. Evidence for this gene reports a log2 fold change of 1.365 and an adjusted p-value of 0.0113. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08032","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the lysosomal membrane. Evidence for this gene reports ... | |
medium_hidden_intermediate_08033 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Evidence for one such gene reports a log2 fold change of 1.894 and an adjusted p-value of 0.00443... | SPARC-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08033","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the regulation of Insulin-like... | |
medium_hidden_intermediate_08035 | Pegivirus C is reported to downregulate a gene that is involved in lysosome organization. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -2.178 and an adjusted p-value of 0.0245. Which protein is encoded by this specific gene? | AP-5 complex subunit mu-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08035","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in lysosome organization. In a study of peripheral blood mon... | |
medium_hidden_intermediate_08036 | Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of cytokine production. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 1.91 and an adjusted p-value of approximately 0.0154. Which protein is encoded by this gene? | Regulator of cell cycle RGCC | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08036","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of cytokine production. Eviden... | |
medium_hidden_intermediate_08037 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes involved in the negative regulation of exocytosis. One such gene exhibited a log2 fold change of approximately 1.196 and an adjusted p-value of 0.008793. Which protein is encoded by this specific gene? | Guanine nucleotide exchange protein SMCR8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08037","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes involved in ... | |
medium_hidden_intermediate_08040 | Hepacivirus C downregulates a specific gene that participates in Viral Infection Pathways. Experimental data for this gene shows a log2 fold change of -1.695 and an adjusted p-value of 0.004984. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08040","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a specific gene that participates in Viral Infection Pathways. Experimental data for this gene s... | |
medium_hidden_intermediate_08041 | Pegivirus C is reported to downregulate a specific gene that participates in neutrophil degranulation. Experimental data for this gene indicates a log2 fold change of -1.546 and an adjusted p-value of 0.03924. In which cell type is this gene enriched? | intermediate monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08041","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that participates in neutrophil degranulation. Experimental data for... | |
medium_hidden_intermediate_08042 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and located in the Golgi membrane. One of these genes exhibits a log2 fold change of 1.265 and an adjusted p-value of 0.00292 in a specific study. Which cell type is enriched for this specific gene? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08042","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and located in the Golgi membrane. One of... | |
medium_hidden_intermediate_08043 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the synthesis of substrates in N-glycan biosynthesis. One of these genes exhibits a log2 fold change of -1.284 and an adjusted p-value of 2.181e-06. What molecular function is enabled by this specific gene? | fucose-1-phosphate guanylyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08043","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the synthesis of sub... | |
medium_hidden_intermediate_08044 | Zika virus infection leads to the upregulation of certain genes that enable sequence-specific DNA binding. In a study of neural stem cells (GSE129180), one such gene exhibited a log2 fold change of approximately 1.38 and an adjusted p-value of 0.0018. Which protein is encoded by this specific gene? | Zinc finger protein 35 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08044","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the upregulation of certain genes that enable sequence-specific DNA binding. In a study of neu... | |
medium_hidden_intermediate_08046 | In the study GSE157852, a specific gene is downregulated by Severe acute respiratory syndrome-related coronavirus and exhibits genomic alterations associated with lung adenocarcinoma. This gene shows a log2 fold change of -1.133 and an adjusted p-value of 0.0002608 in choroid plexus epithelium. Which protein is encoded... | Thyroxine 5-deiodinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08046","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the study GSE157852, a specific gene is downregulated by Severe acute respiratory syndrome-related coronavirus and exhibi... | |
medium_hidden_intermediate_08047 | A gene serves as a marker for Mast cells and is enriched in Naive B cells. Evidence for this gene includes a mean expression of 42.29 TPM, a z-score of 2.04, and a fold enrichment of 7.71. Which disease is associated with this gene as a biomarker? | osteosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08047","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Mast cells and is enriched in Naive B cells. Evidence for this gene includes a mean expression... | |
medium_hidden_intermediate_08048 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene, which in turn interacts with HRAS. This gene exhibited a log2 fold change of -1.679 and an adjusted p-value of 0.0032. Which protein is encoded by this gene? | Ras association domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08048","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_08049 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with BRCA1. Experimental data for this gene reports a log2 fold change of 1.507 and an adjusted p-value of 0.01287. Which protein is encoded by this gene? | Ewing's tumor-associated antigen 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08049","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with BRCA1. Experimental data f... | |
medium_hidden_intermediate_08050 | In a study of Hepacivirus C infection, a specific gene is downregulated by the virus and is associated with hormone activity. Evidence for this gene reports a log2 fold change of -1.334 and an adjusted p-value of 0.0169. Which gene interacts with the gene identified by these statistical values? | ADGRB2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08050","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection, a specific gene is downregulated by the virus and is associated with hormone activity... | |
medium_hidden_intermediate_08051 | Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to MAD1L1 via a binding relationship. One of these genes exhibits a log2 fold change of approximately 3.85 and an adjusted p-value of approximately 0.0006 in pleural mesothelioma cells. Which disease is associated with this ... | hepatitis B virus infection | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08051","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to MAD1L1 via a binding rela... | |
medium_hidden_intermediate_08052 | Hepacivirus C downregulates a specific gene that participates in respiratory electron transport. Transcriptomic data from peripheral blood mononuclear cells (study GSE119117) indicates this gene has a log2 fold change of approximately -1.05 and an adjusted p-value of 0.0156. What molecular function is enabled by this g... | NADH dehydrogenase (ubiquinone) activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08052","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a specific gene that participates in respiratory electron transport. Transcriptomic data from pe... | |
medium_hidden_intermediate_08053 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is upregulated by the virus and participates in DDX58/IFIH1-mediated induction of interferon-alpha/beta. This gene exhibits a log2 fold change of 8.438 and an adjusted p-value of 0.03198. Which mole... | type I interferon receptor binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08053","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is... | |
medium_hidden_intermediate_08054 | Zika virus downregulates a gene that is involved in the tumor necrosis factor-mediated signaling pathway. Experimental data from glioma stem cells (study GSE114907) indicates that this specific gene has a log2 fold change of approximately -1.52 and an adjusted p-value of 0.0118. Which protein is encoded by this gene? | Nuclear receptor subfamily 2 group C member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08054","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the tumor necrosis factor-mediated signaling pathway. Experimental data ... | |
medium_hidden_intermediate_08056 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables enzyme binding. Transcriptomic data for this gene shows a log2 fold change of approximately 1.259 and an adjusted p-value of 0.02347. In which cell type is this gene enriched? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08056","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables enzyme binding. Transcriptomic da... | |
medium_hidden_intermediate_08059 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is enriched in Naive CD8+ T cells. Evidence for this gene reports a log2 fold change of -1.669 and an adjusted p-value of 0.0215. Which protein is encoded by this gene? | Inactive glycosyltransferase 25 family member 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08059","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is enriched in Naive CD8+ T cells. Evid... | |
medium_hidden_intermediate_08060 | Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of ATP-dependent activity. Experimental data from a study on peripheral blood mononuclear cells indicates that this specific gene has a log2 fold change of -1.548 and an adjusted p-value of 0.01459. Which protein is encoded by th... | DnaJ homolog subfamily C member 24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08060","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of ATP-dependent activity. Experi... | |
medium_hidden_intermediate_08061 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with HSPA1A. Experimental data for this gene in lung cells shows a log2 fold change of approximately -1.252 and an adjusted p-value of 0.0001197. Which protein is encoded by this gene? | Transforming acidic coiled-coil-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08061","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with HSPA1A. Experimental data for... | |
medium_hidden_intermediate_08062 | Human betaherpesvirus 5 downregulates a gene that participates in Visual phototransduction. Evidence for one such gene reports a log2 fold change of -1.115 and an adjusted p-value of 2.862e-05. Which disease is associated with that gene as a biomarker? | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08062","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that participates in Visual phototransduction. Evidence for one such gene repor... | |
medium_hidden_intermediate_08064 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated and participates in Signaling by Rho GTPases. This gene exhibits a log2 fold change of -1.034 and an adjusted p-value of 2.779e-06. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08064","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated and... | |
medium_hidden_intermediate_08066 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with Diseases of glycosylation. One of these genes exhibits a log2 fold change of -2.203 and an adjusted p-value of 0.01143 in a specific study. Which protein is encoded by this gene? | Mucin-3A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08066","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with Diseases of gly... | |
medium_hidden_intermediate_08067 | Two genes are structurally linked to Pegivirus C via downregulation and to Mitochondrial protein degradation via participation. One of these genes exhibits a log2 fold change of -1.168 and an adjusted p-value of 0.002681 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | retinitis pigmentosa 90 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08067","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to Mitochondrial protein degradation via participati... | |
medium_hidden_intermediate_08068 | Human betaherpesvirus 5 is reported to downregulate a gene that serves as a biomarker for glioma. In a specific study involving foreskin fibroblast cell lines, this gene exhibited a log2 fold change of approximately -1.03 and an adjusted p-value of approximately 0.0018. Which protein is encoded by this gene? | Lymphokine-activated killer T-cell-originated protein kinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08068","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that serves as a biomarker for glioma. In a specific study involv... | |
medium_hidden_intermediate_08069 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with RAB11A. One of these genes exhibits a log2 fold change of -1.968 and an adjusted p-value of 0.02458 in bronchial epithelial cells. Which protein is encoded by this specific gene? | Ecotropic viral integration site 5 protein homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08069","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with RAB11A. One of these ... | |
medium_hidden_intermediate_08070 | Two biological processes are hierarchically positioned between 'regulation of blood vessel branching' and 'regulation of anatomical structure morphogenesis' via 'is a' relationships. One of these intermediate processes is defined by the evidence: 'Any process that modulates the frequency, rate or extent of blood vessel... | angiogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08070","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two biological processes are hierarchically positioned between 'regulation of blood vessel branching' and 'regulation of ana... | |
medium_hidden_intermediate_08071 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to leiomyoma via an association relationship. One of these genes was reported in a study (GSE157852) involving choroid plexus epithelium, showing a log2 fold change of -2.944 and an adjusted p-value of 0.... | Cellular retinoic acid-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08071","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to leiom... | |
medium_hidden_intermediate_08072 | In the study GSE157852 involving choroid plexus epithelium, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and exhibits genomic alterations in breast carcinoma. This specific gene shows a log2 fold change of approximately 1.312 and an adjusted p-value of 4.246e-05. Which protein is encod... | Transcription factor MafK | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08072","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the study GSE157852 involving choroid plexus epithelium, a gene is upregulated by Severe acute respiratory syndrome-relat... | |
medium_hidden_intermediate_08074 | Two genes are linked to Hepacivirus C via downregulation and to prostate carcinoma via biomarker association. One of these genes exhibits a log2 fold change of approximately -1.051 and an adjusted p-value of 0.03091 in a specific study. Which protein is encoded by the gene matching these statistical values? | Nucleolar and spindle-associated protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08074","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Hepacivirus C via downregulation and to prostate carcinoma via biomarker association. One of these g... | |
medium_hidden_intermediate_08075 | A protein marker expressed on Cytotoxic CD4+ T cells is known to enable protein binding. Experimental evidence indicates that the binding of tandem SH2 domains of SHP-2 to longer peptides containing tandem phosphorylated ITSMs in this specific human protein increases affinity tenfold. Which protein is encoded by the ge... | Natural killer cell receptor 2B4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08075","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein marker expressed on Cytotoxic CD4+ T cells is known to enable protein binding. Experimental evidence indicates tha... | |
medium_hidden_intermediate_08077 | A protein encoded by a gene connected to SH3KBP1 via an interaction and linked to the RHO GTPase cycle via participation is the subject of a study. The study reports that yeast two-hybrid screening of a p53(-/-) astrocyte cDNA library with an SH3 domain identified a novel gene, which shares 55% amino acid identity with... | SH3KBP1-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08077","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein encoded by a gene connected to SH3KBP1 via an interaction and linked to the RHO GTPase cycle via participation is ... | |
medium_hidden_intermediate_08079 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the trans-Golgi network. One of these genes exhibits a log2 fold change of 1.708 and an adjusted p-value of 0.04065 in a specific study. Which disease is associated with this gene as a biomarker? | Mesothelioma, malignant | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08079","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the trans-Golgi networ... | |
medium_hidden_intermediate_08080 | Measles morbillivirus upregulates a gene that participates in the transport of small molecules. Evidence for this gene reports a log2 fold change of 1.244 and an adjusted p-value of 0.00674. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08080","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the transport of small molecules. Evidence for this gene repor... | |
medium_hidden_intermediate_08081 | Pegivirus C is reported to downregulate a specific gene, which is subsequently found to be enriched in Gamma delta (γδ) T cells. Experimental data for this gene indicates a log2 fold change of -1.769 and an adjusted p-value of 0.002799. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08081","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently found to be enriched in Gamma delta (γδ) T ce... | |
medium_hidden_intermediate_08083 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which is involved in the regulation of G protein-coupled receptor signaling pathway. This gene exhibited a log2 fold change of approximately 1.767 and an adjusted p-value of 0.0004459. Which pr... | Chaperone Ric-8B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08083","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_08084 | Measles morbillivirus is reported to upregulate a gene that is associated with carcinoma. Experimental data for this gene shows a log2 fold change of approximately 1.371 and an adjusted p-value of 0.04146. Which protein is encoded by this gene? | Headcase protein homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08084","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus is reported to upregulate a gene that is associated with carcinoma. Experimental data for this gene sh... | |
medium_hidden_intermediate_08085 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. This gene exhibits a log2 fold change of 1.209 and an adjusted p-value of 0.0004572. Which protein is encoded by t... | Kelch repeat and BTB domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08085","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_08086 | A gene is upregulated by Human gammaherpesvirus 8 and is enriched in neutrophils. Evidence for this gene reports a log2 fold change of 1.127 and an adjusted p-value of 0.01344. Which protein is encoded by this gene? | Akirin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08086","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and is enriched in neutrophils. Evidence for this gene reports a log2 fold... | |
medium_hidden_intermediate_08089 | In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and serving as a biomarker for Parkinson disease. This specific gene exhibits a log2 fold change of approximately 1.032 and an adjusted p-value of 0.005077. Which protein is encoded by this gene? | Cathepsin B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08089","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and servi... | |
medium_hidden_intermediate_08091 | Human immunodeficiency virus 1 is known to downregulate multiple genes that are involved in the regulation of DNA-templated transcription. One such gene exhibits a log2 fold change of -1.108 and an adjusted p-value of 0.02473 in macrophages (study GSE108897). Which protein is encoded by this specific gene? | Homeobox protein Hox-B7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08091","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 is known to downregulate multiple genes that are involved in the regulation of DNA-templated ... | |
medium_hidden_intermediate_08092 | Enterovirus A is reported to upregulate a gene product that is located in the extracellular space. In a study of rhabdomyosarcoma cells (GSE103308), one such entity exhibited a log2 fold change of 4.931 and an adjusted p-value of 0.02227. Which disease is associated with this specific entity? | ovarian clear cell adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08092","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to upregulate a gene product that is located in the extracellular space. In a study of rhabdomyosa... | |
medium_hidden_intermediate_08093 | A gene is downregulated by Zika virus and is involved in epithelial cell differentiation. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.554 and an adjusted p-value of 0.0281. Which disease is associated with this gene? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08093","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and is involved in epithelial cell differentiation. Experimental data for this gene in... | |
medium_hidden_intermediate_08094 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specific gene, which in turn interacts with TRIM25. This gene exhibits a log2 fold change of approximately 1.22 and an adjusted p-value of 3.40e-09. Which protein is encoded by this gene? | La-related protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08094","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specifi... | |
medium_hidden_intermediate_08096 | Two genes are structurally linked to Cardiovirus A via an upregulation relationship and to gastric cancer via an association relationship. One of these genes has a reported log2 fold change of 1.762 and an adjusted p-value of 0.03499 in a specific study context. Which protein is encoded by the gene matching these stati... | WAP four-disulfide core domain protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08096","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via an upregulation relationship and to gastric cancer via an association... | |
medium_hidden_intermediate_08097 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a specific gene that participates in Cell-Cell communication. This gene exhibits a log2 fold change of approximately 4.27 and an adjusted p-value of approximately 0.0042. Which biological process is this gene involved in? | cell adhesion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08097","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a specific gene that participates in Cell-... | |
medium_hidden_intermediate_08098 | Zika virus downregulates a specific gene that subsequently interacts with SQSTM1. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.816 and an adjusted p-value of 0.01315. What molecular function is enabled by this gene? | peptidyl-tRNA hydrolase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08098","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that subsequently interacts with SQSTM1. In a study of glioma stem cells (GSE114907... | |
medium_hidden_intermediate_08101 | Zika virus downregulates a specific gene, which in turn interacts with CDC42. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.965 and an adjusted p-value of 0.04271. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08101","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with CDC42. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_08103 | Two genes are structurally linked to Pegivirus C via downregulation and to RHOA via interaction. One of these genes exhibits a log2 fold change of -1.395 and an adjusted p-value of 0.002022 in peripheral blood mononuclear cells. Which cell type is this specific gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08103","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to RHOA via interaction. One of these genes exhibits... | |
medium_hidden_intermediate_08106 | Severe acute respiratory syndrome-related coronavirus is linked to intellectual disability via genomic alterations in genes it downregulates. One such gene exhibits a log2 fold change of -1.409 and an adjusted p-value of 2.729e-05. Which protein is encoded by this specific gene? | Ras-related protein Rab-39B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08106","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is linked to intellectual disability via genomic alterations in genes ... | |
medium_hidden_intermediate_08107 | The biological process 'positive regulation of hemopoiesis' is a subclass of 'positive regulation of biological process' via an intermediate process. Evidence for this intermediate process states: 'Any process that activates or increases the frequency, rate or extent of hemopoiesis.' Which biological process is positiv... | immune system process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08107","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The biological process 'positive regulation of hemopoiesis' is a subclass of 'positive regulation of biological process' via... | |
medium_hidden_intermediate_08109 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the cytoskeleton. Evidence for one such gene reports a log2 fold change of -1.064 and an adjusted p-value of 8.572e-06. Which disease is associated with that gene? | lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08109","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the cytoskeleton. Evidence for... | |
medium_hidden_intermediate_08110 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that participate in Nucleotide Excision Repair. One such gene exhibited a log2 fold change of 1.281 and an adjusted p-value of 0.003623. Which protein is encoded by this specific gene? | DNA polymerase epsilon subunit 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08110","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that partici... | |
medium_hidden_intermediate_08111 | In a study of non-small cell lung adenocarcinoma, a gene upregulated by Influenza A virus and involved in the developmental cell lineages of the exocrine pancreas showed a log2 fold change of approximately 1.19 and an adjusted p-value of 2.54e-10. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08111","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma, a gene upregulated by Influenza A virus and involved in the developmental ... | |
medium_hidden_intermediate_08113 | Zika virus infection is associated with the upregulation of certain genes that are enriched in neutrophils. One such gene exhibits a log2 fold change of 1.163 and an adjusted p-value of 0.04518 in glioblastoma multiforme cancer stem cells (study GSE102924). Which protein is encoded by this specific gene? | Cell cycle progression protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08113","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection is associated with the upregulation of certain genes that are enriched in neutrophils. One such gene ex... | |
medium_hidden_intermediate_08115 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the metabolism of nucleotides. Evidence for this gene reports a log2 fold change of 3.951 and an adjusted p-value of 0.00721. Which disease is associated with this gene through genomic alterations? | clear cell renal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08115","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the metabolism of nucleot... | |
medium_hidden_intermediate_08116 | Human alphaherpesvirus 1 upregulates a gene that interacts with MYC. Evidence for one such gene reports a log2 fold change of approximately 1.004 and an adjusted p-value of 0.03035. Which disease is associated with that gene? | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08116","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that interacts with MYC. Evidence for one such gene reports a log2 fold change o... | |
medium_hidden_intermediate_08117 | Human immunodeficiency virus 1 upregulates a gene that participates in the process where RAB GEFs exchange GTP for GDP on RABs. Evidence for this gene in a specific study (GSE108897) reports a log2 fold change of approximately 1.246 and an adjusted p-value of approximately 0.000656. Which cell type is this gene enriche... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08117","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the process where RAB GEFs exchange GTP for GDP on RA... | |
medium_hidden_intermediate_08118 | Two genes are downregulated by Human immunodeficiency virus 1 and are enriched in naive CD4+ T cells. One of these genes exhibits a log2 fold change of -1.465 and an adjusted p-value of 6.678e-05 in macrophages. Which cellular component is the location of this specific gene? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08118","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and are enriched in naive CD4+ T cells. One of these genes exh... | |
medium_hidden_intermediate_08119 | A specific genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is linked to a gene entity which subsequently interacts with SMURF2. Experimental evidence indicates that Immunoprecipitation (IP) assays demonstrated Smurf2 as a novel interacting protein for this specific gene entity. Which protein is encoded b... | CUE domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08119","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is linked to a gene entity which subsequently inte... | |
medium_hidden_intermediate_08120 | Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and associated with leukemia. One of these genes exhibits a log2 fold change of -1.582 and an adjusted p-value of 0.01399 in a specific study. Which gene interacts with the gene exhibiting these specific statistical values? | VIM | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08120","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and associated with leukemia. One ... | |
medium_hidden_intermediate_08122 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene involved in the regulation of lysosome size. This gene exhibited a log2 fold change of 1.157 and an adjusted p-value of 0.003485. Which protein is encoded by this gene? | BLOC-1-related complex subunit 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08122","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene inv... | |
medium_hidden_intermediate_08123 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn interacts with DYNLL1. This gene exhibited a log2 fold change of approximately 1.35 and an adjusted p-value of 0.00744. Which protein is encoded by this gene? | Lysine-specific demethylase RSBN1L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08123","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_08125 | In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), two genes are downregulated by the virus and known to bind NEDD8. One of these genes exhibits a log2 fold change of -1.789 and an adjusted p-value of 0.02799. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08125","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), two genes are downregulated by the ... | |
medium_hidden_intermediate_08126 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participates in the RAC3 GTPase cycle. This specific gene exhibits a log2 fold change of approximately 1.391 and an adjusted p-value of 0.03703. Which molecular function is enabled by this gene? | phosphatidylinositol-3,4,5-trisphosphate binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08126","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participate... | |
medium_hidden_intermediate_08127 | SQSTM1 interacts with a protein that enables protein binding. Evidence indicates this protein defines the transitional endoplasmic reticulum (tER) and acts as a scaffold for COPII coat assembly. Which disease is associated with this protein as a biomarker? | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08127","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"SQSTM1 interacts with a protein that enables protein binding. Evidence indicates this protein defines the transitional endop... | |
medium_hidden_intermediate_08128 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene that participates in aerobic respiration and respiratory electron transport. One such gene exhibited a log2 fold change of 1.297 and an adjusted p-value of 1.657e-08. Which protein is encoded by this specific... | Distal membrane-arm assembly complex protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08128","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene that partici... | |
medium_hidden_intermediate_08129 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate a specific gene that enables RNA polymerase II transcription regulatory region sequence-specific DNA binding. This gene exhibited a log2 fold change of approximately 1.56 and an adjusted p-value ... | cardiomyopathy, dilated, 100 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08129","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_08130 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is downregulated by the virus and participates in biological oxidations. This gene exhibits a log2 fold change of approximately -1.97 and an adjusted p-value of 0.0002335. Which protein is encoded b... | Mitochondrial amidoxime-reducing component 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08130","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is... | |
medium_hidden_intermediate_08131 | Measles morbillivirus upregulates a gene that is located at the site of double-strand breaks. Evidence for one such gene reports a log2 fold change of 1.791 and an adjusted p-value of 0.0001833. Which protein is encoded by that gene? | SMC5-SMC6 complex localization factor protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08131","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is located at the site of double-strand breaks. Evidence for one such gene rep... | |
medium_hidden_intermediate_08134 | In a study of Measles morbillivirus infection, a specific gene is downregulated and its expression is enriched in classical monocytes. Evidence for this gene reports a log2 fold change of -1.387 and an adjusted p-value of 0.02923. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08134","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is downregulated and its expression is enriched in classical ... | |
medium_hidden_intermediate_08135 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specific gene, which in turn interacts with CD274. This gene exhibits a log2 fold change of 2.121 and an adjusted p-value of 1.895e-10. Which protein is encoded by this gene? | Protein FAM114A2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08135","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specifi... | |
medium_hidden_intermediate_08136 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with C1QBP. This gene exhibited a log2 fold change of -1.809 and an adjusted p-value of 0.003549. Which protein is encoded by this gene? | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08136","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_08138 | Zika virus downregulates a specific gene, which in turn interacts with HSPA8. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -3.56 and an adjusted p-value of approximately 0.0124. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08138","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with HSPA8. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_08139 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Sphingolipid metabolism. Evidence for this gene reports a log2 fold change of 1.264 and an adjusted p-value of 0.02659. Which protein is encoded by this gene? | Ceramide synthase 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08139","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Sphingolipid metabolism. ... | |
medium_hidden_intermediate_08141 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of these genes shows a log2 fold change of approximately 1.67 and an adjusted p-value of approximately 0.0069 in a specific study. Which cell type is enriched for this specific gene? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08141","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of th... | |
medium_hidden_intermediate_08142 | A protein entity interacts with CSNK2A2 and binds to RAD17. Evidence regarding this entity states: 'In this report, we demonstrate that endogenous human Rad17 (hRad17) interacts with the PCNA-related checkpoint proteins hRad1, hRad9, and hHus1.' Which protein is encoded by this entity? | Checkpoint protein HUS1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08142","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein entity interacts with CSNK2A2 and binds to RAD17. Evidence regarding this entity states: 'In this report, we demon... | |
medium_hidden_intermediate_08143 | In the context of Severe acute respiratory syndrome-related coronavirus infection, two genes are linked to hypertensive disorder via genomic alterations and are upregulated by the virus. One of these genes exhibits a log2 fold change of approximately 1.179 and an adjusted p-value of 0.009882 in a specific study. Which ... | DDIT3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08143","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Severe acute respiratory syndrome-related coronavirus infection, two genes are linked to hypertensive diso... | |
medium_hidden_intermediate_08144 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to Platelet activation, signaling and aggregation via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -2... | Proteinase-activated receptor 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08144","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_08146 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of cold-induced thermogenesis. One of these genes exhibits a log2 fold change of 3.636 and an adjusted p-value of 7.515e-05. Which cellular component is the location of this specific gene? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08146","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulati... | |
medium_hidden_intermediate_08149 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and its protein product is located in the extracellular region. Transcriptomic data for this gene in liver tissue (study GSE151803) reports a log2 fold change of -1.054 and an adjusted p-value of 0.02296. Which cell type is this gene enric... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08149","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and its protein product is located in the e... | |
medium_hidden_intermediate_08151 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved in the positive regulation of telomere maintenance via telomerase. Evidence for this gene reports a log2 fold change of 1.559 and an adjusted p-value of 0.0365. Which protein is encoded by this gen... | T-complex protein 1 subunit delta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08151","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved i... | |
medium_hidden_intermediate_08152 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that is located in the axoneme. One such gene exhibited a log2 fold change of 3.845 and an adjusted p-value of 0.01434. Which protein is encoded by this specific gene? | Cilia- and flagella-associated protein 53 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08152","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_08155 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn binds to PKNOX1. The expression data for this intermediate gene shows a log2 fold change of -1.408 and an adjusted p-value of 0.005475. Which protein is encoded by this gene? | Pre-B-cell leukemia transcription factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08155","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_08156 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with VCP. This specific gene exhibits a log2 fold change of 1.453 and an adjusted p-value of 3.144e-05. Which disease is associated with this gene? | glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08156","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with VCP.... | |
medium_hidden_intermediate_08157 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the ubiquitin-dependent protein catabolic process. Evidence for this gene reports a log2 fold change of 1.022 and an adjusted p-value of 0.007601. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase RNF25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08157","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the ubiquitin-dependent protein... | |
medium_hidden_intermediate_08158 | In the context of Human immunodeficiency virus 1 infection, a specific gene is upregulated and subsequently linked to hypertensive disorder via genomic alterations. Experimental data from study GSE108897 in macrophages indicates that this gene exhibits a log2 fold change of approximately 2.38 and an adjusted p-value of... | Protein odd-skipped-related 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08158","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Human immunodeficiency virus 1 infection, a specific gene is upregulated and subsequently linked to hypert... | |
medium_hidden_intermediate_08159 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to cervical cancer as biomarkers. One of these genes exhibits a log2 fold change of -2.509 and an adjusted p-value of 0.0001 in choroid plexus epithelium. Which cellular component is the location of this specific gene? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08159","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to cervical cancer as b... | |
medium_hidden_intermediate_08160 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with myeloid leukemia. One of these genes exhibits a log2 fold change of 1.656 and an adjusted p-value of 0.02818 in lung tissue data from study GSE155241. Which cell type is enriched for this specific gene? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08160","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with myeloid leukemia.... | |
medium_hidden_intermediate_08163 | A gene is upregulated by Measles morbillivirus and participates in Mitochondrial biogenesis. Evidence for this gene reports a log2 fold change of 1.420 and an adjusted p-value of 0.00886. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08163","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in Mitochondrial biogenesis. Evidence for this gene reports ... | |
medium_hidden_intermediate_08164 | A gene is downregulated by Primate bocaparvovirus 1 and is involved in the negative regulation of the apoptotic process. Experimental data for this gene in vascular endothelial cells (study GSE16354) reports a log2 fold change of -2.136 and an adjusted p-value of 0.04951. Which disease is associated with this gene as a... | systemic lupus erythematosus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08164","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is involved in the negative regulation of the apoptotic process. Exp... | |
medium_hidden_intermediate_08165 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the endoplasmic reticulum membrane. This specific gene exhibits a log2 fold change of 4.476 and an adjusted p-value of 0.0009264. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08165","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the endoplasmic ... | |
medium_hidden_intermediate_08166 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its product is located in the perinuclear region of the cytoplasm. Transcriptomic data for this gene shows a log2 fold change of 1.932 and an adjusted p-value of 0.008747. Which protein is encoded by this gene? | Sodium/myo-inositol cotransporter | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08166","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its product is located in the perinuclear... | |
medium_hidden_intermediate_08168 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in hemostasis. Experimental data for this gene in bronchial epithelial cells shows a log2 fold change of 2.876 and an adjusted p-value of 0.0002509. Which protein does this gene product bind to? | TEK | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08168","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in hemostasis. Exper... |
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