qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_hidden_intermediate_08170 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the activation of NMDA receptors and postsynaptic events. One such gene exhibits a log2 fold change of 1.653 and an adjusted p-value of 0.0001794. Which protein is encoded by this specific gene? | Tubulin beta-2B chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08170","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the activation... | |
medium_hidden_intermediate_08173 | Pegivirus C is reported to downregulate a gene that enables glycerol-3-phosphate O-acyltransferase activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.134 and an adjusted p-value of 0.003194. Which protein is encoded by this specific gen... | Glycerol-3-phosphate acyltransferase 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08173","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables glycerol-3-phosphate O-acyltransferase activity. In a study of p... | |
medium_hidden_intermediate_08175 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Phase 2 - plateau phase. Evidence for this gene reports a log2 fold change of 2.166 and an adjusted p-value of 0.007859. Which protein is encoded by this gene? | Potassium voltage-gated channel subfamily E member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08175","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Phase 2 - plateau pha... | |
medium_hidden_intermediate_08176 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in Co-inhibition by PD-1. Evidence for this specific gene reports a log2 fold change of approximately 2.354 and an adjusted p-value of 1.23e-09. Which protein is encoded by this gene? | Ubiquitin C-terminal hydrolase PSMD14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08176","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in Co-... | |
medium_hidden_intermediate_08178 | Two genes are structurally linked to Enterovirus A via downregulation and to breast cancer via biomarker association. One of these genes exhibits a log2 fold change of -1.151 and an adjusted p-value of 0.01334 in rhabdomyosarcoma cells (study GSE103308). Which biological process is associated with this specific gene th... | natural killer cell differentiation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08178","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via downregulation and to breast cancer via biomarker association. One of... | |
medium_hidden_intermediate_08179 | In a study of rhabdomyosarcoma cells (GSE103308), a specific gene is downregulated by Enterovirus A and is enriched in conventional dendritic cells. This gene exhibits a log2 fold change of -1.980 and an adjusted p-value of 0.01421. Which protein is encoded by this gene? | Sesquipedalian-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08179","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), a specific gene is downregulated by Enterovirus A and is enriched in conve... | |
medium_hidden_intermediate_08180 | Rift Valley fever phlebovirus upregulates a gene that is associated with prostate cancer. Evidence for this gene reports a log2 fold change of 1.966 and an adjusted p-value of 0.005678. Which cell type is this gene enriched in? | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08180","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that is associated with prostate cancer. Evidence for this gene reports a l... | |
medium_hidden_intermediate_08183 | A gene serves as a marker for Oogenesis phase fetal germ cells and is enriched in Plasmacytoid dendritic cells (pDCs). Evidence for one such gene reports a mean expression of 75.94 TPM, a z-score of 4.11, and a fold enrichment of 397.43. Which disease is associated with genomic alterations in that specific gene? | leukodystrophy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08183","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Oogenesis phase fetal germ cells and is enriched in Plasmacytoid dendritic cells (pDCs). Evide... | |
medium_hidden_intermediate_08185 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and located in the lamellipodium. Experimental data for this gene reports a log2 fold change of 1.585 and an adjusted p-value of 0.0012. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08185","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and located in the lamellipodium. Experimenta... | |
medium_hidden_intermediate_08186 | Hepacivirus C is reported to upregulate a specific gene, which is in turn enriched in classical monocytes. Experimental data for this gene shows a log2 fold change of 4.513 and an adjusted p-value of 0.003969. Which protein is encoded by this gene? | Ribonuclease pancreatic | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08186","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a specific gene, which is in turn enriched in classical monocytes. Experimental data... | |
medium_hidden_intermediate_08188 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in erythrocyte differentiation. Evidence for this gene reports a log2 fold change of 1.882 and an adjusted p-value of 0.007146. Which disease is associated with this gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08188","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in erythrocyte differentiatio... | |
medium_hidden_intermediate_08189 | Pegivirus C is reported to downregulate a gene that participates in the synthesis of substrates in N-glycan biosynthesis. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this specific gene has a log2 fold change of -1.497 and an adjusted p-value of 0.00667. Which disease ... | congenital disorder of glycosylation, type 1DD | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08189","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in the synthesis of substrates in N-glycan biosynthesis. Ex... | |
medium_hidden_intermediate_08190 | Hepacivirus C upregulates a gene that enables GTPase activity. One such gene exhibits a log2 fold change of 1.674 and an adjusted p-value of 0.01189 in hepatocytes. Which gene interacts with this upregulated gene? | RAB4A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08190","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables GTPase activity. One such gene exhibits a log2 fold change of 1.674 and an adj... | |
medium_hidden_intermediate_08191 | Zika virus downregulates a gene that is involved in the regulation of double-strand break repair. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.246 and an adjusted p-value of 0.00257. Which protein is encoded by this gene? | Serine/threonine-protein phosphatase 4 regulatory subunit 3B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08191","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the regulation of double-strand break repair. In a study of glioma stem ... | |
medium_hidden_intermediate_08192 | Zika virus downregulates a gene that is located in the membrane raft. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.851 and an adjusted p-value of 0.008893. Which disease is associated with this gene? | open-angle glaucoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08192","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the membrane raft. Evidence for this gene in glioma stem cells (study GSE... | |
medium_hidden_intermediate_08193 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with acute myeloid leukemia. One of these genes exhibits a log2 fold change of 3.474 and an adjusted p-value of 2.484e-08 in a specific study. Which protein is encoded by this gene? | Olfactomedin-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08193","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with acute myeloid leu... | |
medium_hidden_intermediate_08194 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the voltage-gated potassium channel complex. Evidence for one such gene reports a log2 fold change of approximately 1.001 and an adjusted p-value of 0.00611. Which protein is encoded by that gene? | ATP-sensitive inward rectifier potassium channel 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08194","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the voltage-gated potassium chan... | |
medium_hidden_intermediate_08195 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the axoneme. One of these genes shows a log2 fold change of 1.043 and an adjusted p-value of 0.04493 in a specific study. Which disease is associated with this specific gene? | Young syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08195","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the axoneme. One of th... | |
medium_hidden_intermediate_08196 | Human immunodeficiency virus 1 upregulates a gene that is involved in angiogenesis. Evidence for this gene reports a log2 fold change of 2.449 and an adjusted p-value of 0.02955. Which protein is encoded by this gene? | Multimerin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08196","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in angiogenesis. Evidence for this gene reports a log2 fo... | |
medium_hidden_intermediate_08197 | Hepacivirus C upregulates a gene that interacts with YWHAB. One such gene exhibits a log2 fold change of 1.038 and an adjusted p-value of 6.671e-06. Which protein is encoded by this gene? | DENN domain-containing protein 4C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08197","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that interacts with YWHAB. One such gene exhibits a log2 fold change of 1.038 and an adjust... | |
medium_hidden_intermediate_08199 | Enterovirus A infection leads to the upregulation of specific genes whose protein products are located in the mitochondrial matrix. In a study of rhabdomyosarcoma cells (GSE103308), one such upregulated entity exhibited a log2 fold change of approximately 1.384 and an adjusted p-value of 0.01075. Which protein is encod... | Mitochondrial tRNA methylthiotransferase CDK5RAP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08199","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A infection leads to the upregulation of specific genes whose protein products are located in the mitochondrial ... | |
medium_hidden_intermediate_08201 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and enables metal ion binding. This gene exhibits a log2 fold change of approximately 1.695 and an adjusted p-value of 0.01534. Which protein is encoded by this gene? | Pirin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08201","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and enables metal ion binding... | |
medium_hidden_intermediate_08202 | A gene expressed in multipotent progenitor cells and known to enable protein binding is the subject of evidence stating that ultraviolet irradiation induces its phosphorylation at serine 602 by AKT, thereby increasing its association with nucleophosmin. Which disease is associated with this gene? | renal cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08202","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene expressed in multipotent progenitor cells and known to enable protein binding is the subject of evidence stating that... | |
medium_hidden_intermediate_08203 | PARP1 interacts with a protein that enables histone binding. Evidence indicates that this protein interacts directly with PARP1 and is required for its activation and for cellular resistance to methyl-methane sulfonate. Which gene encodes this protein? | Aprataxin and PNK-like factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08203","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PARP1 interacts with a protein that enables histone binding. Evidence indicates that this protein interacts directly with PA... | |
medium_hidden_intermediate_08206 | A gene is downregulated by Primate bocaparvovirus 1 and is enriched in plasmacytoid dendritic cells. Evidence for this gene reports a log2 fold change of -1.183 and an adjusted p-value of 0.0458. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08206","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is enriched in plasmacytoid dendritic cells. Evidence for this gene ... | |
medium_hidden_intermediate_08208 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein tyrosine phosphatase activity. Evidence for this gene reports a log2 fold change of approximately 1.29 and an adjusted p-value of 0.000127. Which disease is associated with this gene as a biomarker? | Parkinson disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08208","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein tyrosine phosphatase acti... | |
medium_hidden_intermediate_08211 | In a study of non-small cell lung adenocarcinoma cell lines, a gene is upregulated by Influenza A virus and participates in Co-stimulation by CD28. Evidence for this specific gene reports a log2 fold change of approximately 1.35 and an adjusted p-value of 4.41e-08. Which protein is encoded by this gene? | Tyrosine-protein kinase Yes | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08211","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines, a gene is upregulated by Influenza A virus and participates in ... | |
medium_hidden_intermediate_08212 | MIR140 is involved in a biological process that is a subclass of negative regulation of cytokine production. Experimental evidence indicates that transfection with miR-140 mimics leads to decreased levels of TLR4, TNF-α, and Interleukin 6 (IL-6). Which specific biological process, connected to MIR140 via 'involved in',... | cytokine production involved in inflammatory response | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08212","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"MIR140 is involved in a biological process that is a subclass of negative regulation of cytokine production. Experimental ev... | |
medium_hidden_intermediate_08213 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes whose protein products are located in the mitotic spindle. One such gene exhibited a log2 fold change of approximately 3.26 and an adjusted p-value of 2.20e-11. Which protein is encoded by this specifi... | Small kinetochore-associated protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08213","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes whose... | |
medium_hidden_intermediate_08214 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that participates in the conjugation of salicylate with glycine. Evidence for this specific gene reports a log2 fold change of 2.575 and an adjusted p-value of 0.003988. Which molecular function is enabled by this gene? | glycine N-acyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08214","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that participates in the conj... | |
medium_hidden_intermediate_08215 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and located in the extracellular matrix. Evidence for this gene reports a log2 fold change of -1.576 and an adjusted p-value of 0.009269. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08215","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and located in the extracellular matrix. Ev... | |
medium_hidden_intermediate_08217 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the CDC42 GTPase cycle. One of these genes was reported in a study (GSE155241) on lung cells with a log2 fold change of 1.624 and an adjusted p-value of 0.04618. Which protein does this specific gene bind to? | RHOQ | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08217","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the CDC42 GTPase cycle... | |
medium_hidden_intermediate_08218 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and involved in chloride transport. This gene exhibits a log2 fold change of 1.452 and an adjusted p-value of 2.89e-09. Which protein is encoded by this gene? | Proton-activated chloride channel | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08218","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and involved in chl... | |
medium_hidden_intermediate_08219 | Zika virus downregulates a gene that interacts with KIAA0753. Evidence for this gene reports a log2 fold change of -2.484 and an adjusted p-value of 0.004071. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08219","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with KIAA0753. Evidence for this gene reports a log2 fold change of -2.484 an... | |
medium_hidden_intermediate_08220 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene, which in turn participates in organelle biogenesis and maintenance. This gene exhibited a log2 fold change of approximately -1.189 and an adjusted p-value of 0.02083. Which protein is encoded... | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08220","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_08221 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with myeloid leukemia. One of these genes exhibits a log2 fold change of 1.716 and an adjusted p-value of 0.003172 in a specific study. Which cell type is enriched for this specific gene? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08221","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with myeloid leukemia.... | |
medium_hidden_intermediate_08222 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus shows a log2 fold change of -7.325 and an adjusted p-value of 0.04159. This gene is part of a pathway where an interacting partner binds to SRC. Which protein is encoded by this downregulated gene? | Protein TAMALIN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08222","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus shows a log2 fold change... | |
medium_hidden_intermediate_08224 | Cardiovirus A downregulates a specific gene that enables protein homodimerization activity. In a study of cervical adenocarcinoma cell lines (GSE122967), this gene exhibited a log2 fold change of approximately -1.78 and an adjusted p-value of 0.0087. Which disease is associated with genomic alterations in this gene? | bipolar disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08224","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a specific gene that enables protein homodimerization activity. In a study of cervical adenocarc... | |
medium_hidden_intermediate_08226 | Human alphaherpesvirus 1 upregulates a gene that participates in post-translational protein modification. In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of 1.368 and an adjusted p-value of 0.007482. Which protein is encoded by this gene? | Diphosphomevalonate decarboxylase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08226","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in post-translational protein modification. In a study of mono... | |
medium_hidden_intermediate_08227 | A gene is identified as a marker for germ cells and is known to enable protein kinase binding. Evidence indicates that this gene, along with Tom1, associates with Src and affects mitogenic signaling, suggesting functional redundancy within the Tom1 family. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08227","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is identified as a marker for germ cells and is known to enable protein kinase binding. Evidence indicates that this ... | |
medium_hidden_intermediate_08228 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate specific genes involved in extracellular matrix organization. One such gene exhibited a log2 fold change of -3.236 and an adjusted p-value of 0.001165. What molecular function is enabled by this specific gene? | extracellular matrix structural constituent conferring tensile strength | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08228","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate specific genes involved ... | |
medium_hidden_intermediate_08229 | Pegivirus C is reported to downregulate a gene that enables 1-phosphatidylinositol binding. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.090 and an adjusted p-value of 0.007221. Which protein is encoded by this specific gene? | WD repeat and FYVE domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08229","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables 1-phosphatidylinositol binding. In a study of peripheral blood m... | |
medium_hidden_intermediate_08232 | Human betaherpesvirus 5 downregulates a gene that participates in the process 'PPARA activates gene expression'. Evidence for this specific gene reports a log2 fold change of -1.408 and an adjusted p-value of 2.881e-05. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08232","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that participates in the process 'PPARA activates gene expression'. Evidence fo... | |
medium_hidden_intermediate_08233 | A brain neoplasm is localized to a specific bone that overlaps with the chondrocranium. Evidence describing this bone states: 'The bone at the lower, posterior part of the skull.' Which anatomical structure does this bone develop from? | sclerotome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08233","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A brain neoplasm is localized to a specific bone that overlaps with the chondrocranium. Evidence describing this bone states... | |
medium_hidden_intermediate_08235 | In transcriptomic studies of lung tissue, Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) infection has been shown to upregulate specific genes that are localized to the glutamatergic synapse. One such gene exhibits a log2 fold change of 1.851 and an adjusted p-value of 0.002223. What molecular funct... | serine-type peptidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08235","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In transcriptomic studies of lung tissue, Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) infection has b... | |
medium_hidden_intermediate_08236 | A gene is upregulated by Zika virus and participates in Metabolism. Experimental data for this gene reports a log2 fold change of approximately 1.22 and an adjusted p-value of 0.0357. Which disease is associated with this gene through genomic alterations? | coronary stenosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08236","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Zika virus and participates in Metabolism. Experimental data for this gene reports a log2 fold chan... | |
medium_hidden_intermediate_08237 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to VAPA via an 'interacts with' relationship. One of these genes exhibits a log2 fold change of -1.786 and an adjusted p-value of 0.0032 in macrophages (study GSE108897). Which biological process is the gene match... | BMP signaling pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08237","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to VAPA via an 'i... | |
medium_hidden_intermediate_08238 | Hepacivirus C upregulates a gene that participates in the metabolism of water-soluble vitamins and cofactors. In a study of hepatocytes (GSE132606), one such gene showed a log2 fold change of 1.290 and an adjusted p-value of 2.435e-05. Which protein is encoded by this specific gene? | Pantetheine hydrolase VNN2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08238","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the metabolism of water-soluble vitamins and cofactors. In a study of ... | |
medium_hidden_intermediate_08239 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that binds to COX6C. Evidence for this gene reports a log2 fold change of 2.144 and an adjusted p-value of 0.02747. Which protein is encoded by this gene? | Cytochrome c oxidase subunit 6B2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08239","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that binds to COX6C. Evidence for this gene reports... | |
medium_hidden_intermediate_08241 | A brain neoplasm is localized to an anatomy that is an ectoderm-derived structure. Evidence identifies this anatomy as the cranial nerve that transmits sound and equilibrium (balance) information from the inner ear to the brain. Which structure does this anatomy develop from? | otic placode | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08241","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A brain neoplasm is localized to an anatomy that is an ectoderm-derived structure. Evidence identifies this anatomy as the c... | |
medium_hidden_intermediate_08242 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific histone variant that participates in Metalloprotease DUBs. This entity exhibits a log2 fold change of approximately 3.026 and an adjusted p-value of 0.004985. Which protein is encoded by this upregulated entity? | Histone H2A type 1-H | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08242","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific histone variant that part... | |
medium_hidden_intermediate_08243 | Pegivirus C is reported to downregulate a gene that enables magnesium ion binding. Among the genes fitting this description, one exhibits a log2 fold change of -1.796 and an adjusted p-value of 0.02798 in peripheral blood mononuclear cells (study GSE131504). Which disease is associated with this specific gene through g... | triple-negative breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08243","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables magnesium ion binding. Among the genes fitting this description,... | |
medium_hidden_intermediate_08245 | Two genes are upregulated by Human immunodeficiency virus 1 and serve as biomarkers for breast carcinoma. One of these genes exhibits a log2 fold change of approximately 1.44 and an adjusted p-value of approximately 0.0046 in macrophages. Which cellular component is the location of this specific gene? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08245","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and serve as biomarkers for breast carcinoma. One of these genes... | |
medium_hidden_intermediate_08246 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequently interacts with LMNA. Evidence for this gene reports a log2 fold change of 1.510 and an adjusted p-value of 0.001926. Which protein is encoded by this gene? | Soluble lamin-associated protein of 75 kDa | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08246","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequent... | |
medium_hidden_intermediate_08247 | Human immunodeficiency virus 1 upregulates a gene that is located in the extracellular matrix. Evidence for this gene reports a log2 fold change of 2.784 and an adjusted p-value of 0.001801. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08247","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the extracellular matrix. Evidence for this gene report... | |
medium_hidden_intermediate_08249 | Human betaherpesvirus 5 is reported to upregulate a gene that is enriched in basophils. Evidence for this specific gene reports a log2 fold change of 3.041 and an adjusted p-value of 0.04666. Which protein is encoded by this gene? | N-acylglucosamine 2-epimerase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08249","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is enriched in basophils. Evidence for this specific gene repo... | |
medium_hidden_intermediate_08250 | A gene is downregulated by Zika virus and binds to WDR46. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.66 and an adjusted p-value of 0.0046. Which disease is associated with this gene as a biomarker? | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08250","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and binds to WDR46. Experimental data for this gene in glioma stem cells (study GSE114... | |
medium_hidden_intermediate_08251 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to gastric cancer as biomarkers. One of these genes exhibits a log2 fold change of 2.265 and an adjusted p-value of 0.004766 in lung tissue data from study GSE148697. Which cellular component is associated with this speci... | voltage-gated potassium channel complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08251","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to gastric cancer as biom... | |
medium_hidden_intermediate_08252 | Human betaherpesvirus 5 upregulates a gene that enables enzyme binding. Evidence for this gene reports a log2 fold change of 3.664 and an adjusted p-value of 0.02313. Which protein is encoded by this gene? | Serpin B4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08252","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that enables enzyme binding. Evidence for this gene reports a log2 fold change of... | |
medium_hidden_intermediate_08253 | Human immunodeficiency virus 1 downregulates a gene that is involved in the positive regulation of autophagosome assembly. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.57 and an adjusted p-value of approximately 0.005. Which protein is encoded by this gene? | Modulator of apoptosis 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08253","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the positive regulation of autophagosome assembly. I... | |
medium_hidden_intermediate_08254 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and involved in signal transduction. This gene exhibits a log2 fold change of approximately 1.505 and an adjusted p-value of 1.17e-08. Which protein is encoded by this gene? | Nuclear factor of activated T-cells 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08254","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_08256 | A gene is upregulated by Human immunodeficiency virus 1 and participates in Phospholipid metabolism. Evidence for this gene reports a log2 fold change of 1.138 and an adjusted p-value of 0.000158. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08256","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and participates in Phospholipid metabolism. Evidence for this gene ... | |
medium_hidden_intermediate_08258 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its product enables calcium ion binding. Evidence for this gene reports a log2 fold change of approximately -1.01 and an adjusted p-value of 0.0002252. Which protein is encoded by this gene? | Prothymosin alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08258","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its prod... | |
medium_hidden_intermediate_08259 | Zika virus downregulates a gene that interacts with MATR3. Evidence for this gene reports a log2 fold change of approximately -1.10 and an adjusted p-value of 0.0065. In which cell type is this gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08259","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with MATR3. Evidence for this gene reports a log2 fold change of approximatel... | |
medium_hidden_intermediate_08260 | Two genes are linked to Enterovirus A via downregulation and to schizophrenia via biomarker association. One of these genes exhibits a log2 fold change of approximately -2.006 and an adjusted p-value of 0.01276 in rhabdomyosarcoma cells. Which protein is encoded by this specific gene? | Phospholipid scramblase 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08260","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Enterovirus A via downregulation and to schizophrenia via biomarker association. One of these genes ... | |
medium_hidden_intermediate_08261 | Two genes are linked to Vaccinia virus via upregulation and to depressive disorder via biomarker association. One of these genes exhibits a log2 fold change of 2.727 and an adjusted p-value of 3.3e-07 in cervical adenocarcinoma cell lines. Which cellular component is the location of this specific gene? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08261","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Vaccinia virus via upregulation and to depressive disorder via biomarker association. One of these g... | |
medium_hidden_intermediate_08262 | Human betaherpesvirus 5 upregulates a gene that participates in Signal Transduction. Experimental data for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of approximately 1.606 and an adjusted p-value of approximately 0.0316. Which molecular function is enabled by this gene? | guanyl-nucleotide exchange factor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08262","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in Signal Transduction. Experimental data for this gene in fore... | |
medium_hidden_intermediate_08263 | The gene CACNA1C is involved in a specific biological process that is a subtype of membrane depolarization during cardiac muscle cell action potential. Evidence for this specific process describes it as the event where the AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the neg... | AV node cell action potential | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08263","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The gene CACNA1C is involved in a specific biological process that is a subtype of membrane depolarization during cardiac mu... | |
medium_hidden_intermediate_08265 | Cardiovirus A infection leads to the downregulation of certain genes whose protein products are located in the centrosome. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibited a log2 fold change of approximately -1.435 and an adjusted p-value of 0.0162. Which protein is encoded by this ... | Centrosomal protein of 44 kDa | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08265","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A infection leads to the downregulation of certain genes whose protein products are located in the centrosome. I... | |
medium_hidden_intermediate_08266 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to RBBP7. This specific gene exhibits a log2 fold change of 2.829 and an adjusted p-value of 1.126e-09. Which gene interacts with this identified entity? | NDEL1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08266","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to RBBP7. Thi... | |
medium_hidden_intermediate_08267 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in protein maturation. Evidence for this gene reports a log2 fold change of -1.165 and an adjusted p-value of 0.001974. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08267","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in protein maturation. Evidence ... | |
medium_hidden_intermediate_08268 | Pegivirus C is reported to downregulate a gene whose product is located in the early endosome. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -2.17 and an adjusted p-value of 0.0129. Which protein is encoded by this specific gene? | Ribosomal protein S6 kinase delta-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08268","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene whose product is located in the early endosome. In a study of peripheral bloo... | |
medium_hidden_intermediate_08269 | Two genes are known to interact with KRAS and are enriched in neutrophils. One of these genes exhibits a mean expression of 65.29 TPM, a z-score of 2.37, and a fold enrichment of 7.02 in immune cell RNA-seq data. Which biological process is the gene matching these expression statistics involved in? | negative regulation of adiponectin secretion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08269","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are known to interact with KRAS and are enriched in neutrophils. One of these genes exhibits a mean expression of ... | |
medium_hidden_intermediate_08271 | Human immunodeficiency virus 1 upregulates a gene that enables structural molecule activity. Evidence for this gene in a specific study reports a log2 fold change of approximately 2.67 and an adjusted p-value of approximately 0.00079. Which cell type is this gene enriched in? | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08271","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables structural molecule activity. Evidence for this gene in a spe... | |
medium_hidden_intermediate_08272 | Human betaherpesvirus 5 upregulates a gene that participates in signal transduction. Experimental data for this gene in monocytes from study GSE11408 show a log2 fold change of 1.082 and an adjusted p-value of 0.03656. Which biological process is this gene involved in? | negative regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08272","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in signal transduction. Experimental data for this gene in mono... | |
medium_hidden_intermediate_08273 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cellular responses to stimuli. Transcriptomic data for this gene reports a log2 fold change of -1.311 and an adjusted p-value of 0.003773. Which protein is encoded by this gene? | LIM domain-containing protein ajuba | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08273","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cellular responses to s... | |
medium_hidden_intermediate_08274 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with adenocarcinoma. One of these genes exhibits a log2 fold change of 1.575 and an adjusted p-value of 0.009409 in bronchial epithelial cells. What molecular function is enabled by this specific gene? | serine-type endopeptidase inhibitor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08274","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with adenocarcinoma. O... | |
medium_hidden_intermediate_08276 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which in turn interacts with MYC. This gene exhibits a log2 fold change of 1.204 and an adjusted p-value of 0.03278. What protein is encoded by this gene? | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08276","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_08277 | A gene is upregulated by Primate bocaparvovirus 1 and is enriched in basophils. Evidence for this gene reports a log2 fold change of 4.949 and an adjusted p-value of 0.01673. Which protein is encoded by this gene? | S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08277","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is enriched in basophils. Evidence for this gene reports a log2 fold c... | |
medium_hidden_intermediate_08279 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in immunoregulatory interactions between a lymphoid and a non-lymphoid cell. Evidence for one such gene reports a log2 fold change of 1.004 and an adjusted p-value of 4.957e-10. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08279","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in immunoregulatory interactions ... | |
medium_hidden_intermediate_08280 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and enable DNA-binding transcription activator activity, RNA polymerase II-specific. One of these genes exhibits a log2 fold change of 1.870 and an adjusted p-value of 0.002232 in lung cells. Which biological process is this specific gen... | positive regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08280","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and enable DNA-binding transcription acti... | |
medium_hidden_intermediate_08282 | Pegivirus C is reported to downregulate a gene that enables cysteine-type deubiquitinase activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of approximately -1.156 and an adjusted p-value of 0.01951. Which protein is encoded by this specific gene? | Ubiquitin carboxyl-terminal hydrolase 42 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08282","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables cysteine-type deubiquitinase activity. In a study of peripheral ... | |
medium_hidden_intermediate_08283 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables GTPase activity. Transcriptomic data for this gene in bronchial epithelial cells shows a log2 fold change of approximately 1.24 and an adjusted p-value of approximately 0.044. Which protein is encoded by this gene? | NF-kappa-B inhibitor-interacting Ras-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08283","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables GTPase activity. Transcriptomic data f... | |
medium_hidden_intermediate_08284 | Human immunodeficiency virus 1 upregulates a gene that is located in the extracellular matrix. Evidence for this gene reports a log2 fold change of 5.177 and an adjusted p-value of 0.005031. Which cell type is this gene enriched in? | intermediate monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08284","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the extracellular matrix. Evidence for this gene report... | |
medium_hidden_intermediate_08285 | Hepacivirus C upregulates a gene that is involved in the antibacterial humoral response. Evidence for one such gene reports a log2 fold change of 2.796 and an adjusted p-value of 0.0001613. Which disease is associated with this gene as a biomarker? | hyperlipidemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08285","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the antibacterial humoral response. Evidence for one such gene reports ... | |
medium_hidden_intermediate_08286 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes involved in the negative regulation of DNA-templated transcription. One such gene exhibits a log2 fold change of approximately 1.695 and an adjusted p-value of 0.04764. Which protein is encoded by this s... | Zinc finger protein 540 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08286","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes involve... | |
medium_hidden_intermediate_08290 | Two genes are upregulated by Vaccinia virus and participate in Phospholipid metabolism. One of these genes exhibits a log2 fold change of 1.295 and an adjusted p-value of 1.685e-08 in cervical adenocarcinoma cell lines. Which disease is associated with genomic alterations in this specific gene? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08290","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in Phospholipid metabolism. One of these genes exhibits a log2 f... | |
medium_hidden_intermediate_08291 | A gene is downregulated by Primate bocaparvovirus 1 and is involved in the heparan sulfate proteoglycan biosynthetic process. Experimental evidence for this gene reports a log2 fold change of -1.963 and an adjusted p-value of 0.03983. Which protein is encoded by this gene? | Exostosin-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08291","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is involved in the heparan sulfate proteoglycan biosynthetic process... | |
medium_hidden_intermediate_08292 | Human betaherpesvirus 5 is reported to downregulate a gene that subsequently interacts with ANLN. In a study using foreskin fibroblast cell lines, one such intermediate gene exhibited a log2 fold change of approximately -1.091 and an adjusted p-value of 0.04596. Which protein is encoded by this specific gene? | Actin-related protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08292","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that subsequently interacts with ANLN. In a study using foreskin ... | |
medium_hidden_intermediate_08294 | Zika virus downregulates a specific gene, which in turn interacts with HIF1A. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.007 and an adjusted p-value of 0.01224. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08294","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with HIF1A. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_08296 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participates in the metabolism of vitamins and cofactors. This specific gene exhibits a log2 fold change of 2.448 and an adjusted p-value of 0.01341. Which protein is encoded by this gene? | Protein mono-ADP-ribosyltransferase PARP9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08296","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participate... | |
medium_hidden_intermediate_08297 | A genetic variant NM_015600.4(ABHD12):c.-6898_191+7002delinsCC is linked to a gene that enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. Evidence indicates this gene encodes a ubiquitously expressed transcription factor that is homologous to ATF2 and binds to CRE elements within specific p... | hypersensitivity reaction disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08297","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A genetic variant NM_015600.4(ABHD12):c.-6898_191+7002delinsCC is linked to a gene that enables RNA polymerase II cis-regula... | |
medium_hidden_intermediate_08298 | Pegivirus C downregulates a gene that interacts with BAG2. Evidence for one such gene reports a log2 fold change of -1.439 and an adjusted p-value of 0.004405. Which biological process is this gene involved in? | endoplasmic reticulum calcium ion homeostasis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08298","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that interacts with BAG2. Evidence for one such gene reports a log2 fold change of -1.439 a... | |
medium_hidden_intermediate_08299 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in nucleotide salvage was found to have a log2 fold change of approximately 4.10 and an adjusted p-value of 1.055e-07. Which protein does this specific gene product interact with? | UCK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08299","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in nucleotide... | |
medium_hidden_intermediate_08300 | Pegivirus C is reported to downregulate a gene that is located in chromatin. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.823 and an adjusted p-value of 0.0001805. Which gene interacts with this specific downregulated gene? | PRKAB2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08300","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in chromatin. In a study of peripheral blood mononuclear cell... | |
medium_hidden_intermediate_08302 | Zika virus downregulates a gene involved in protein histidyl modification to diphthamide. Evidence for one such gene reports a log2 fold change of -1.273 and an adjusted p-value of 0.02117. Which protein is encoded by that gene? | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08302","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene involved in protein histidyl modification to diphthamide. Evidence for one such gene reports... | |
medium_hidden_intermediate_08303 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in flagellated sperm motility. Evidence for this gene reports a log2 fold change of 1.475 and an adjusted p-value of 0.0008199. Which cellular component is this gene located in? | axoneme | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08303","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in flagellated sperm motility... | |
medium_hidden_intermediate_08304 | Measles morbillivirus upregulates a gene that enables molecular adaptor activity. Evidence for one such gene reports a log2 fold change of 1.601 and an adjusted p-value of 0.0008035. Which cellular component is that gene located in? | Golgi membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08304","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that enables molecular adaptor activity. Evidence for one such gene reports a log2 ... | |
medium_hidden_intermediate_08305 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with EGFR. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) show a log2 fold change of approximately -1.43 and an adjusted p-value of 0.00376. Which biological process is this gene involved in? | tRNA export from nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08305","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with EGFR. Experimental data for this gene ... | |
medium_hidden_intermediate_08307 | Two genes are linked to Enterovirus A via downregulation and to breast cancer via biomarker association. One of these genes exhibits a log2 fold change of -1.248 and an adjusted p-value of 0.04295 in rhabdomyosarcoma cells (study GSE103308). Which protein is encoded by this specific gene? | Mitogen-activated protein kinase kinase kinase 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08307","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Enterovirus A via downregulation and to breast cancer via biomarker association. One of these genes ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.