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medium_hidden_intermediate_08308 | Zika virus downregulates a specific gene, which in turn interacts with UBC. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.36 and an adjusted p-value of 0.0177. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08308","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with UBC. Experimental data for this gene in glioma stem c... | |
medium_hidden_intermediate_08309 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in the regulation of the apoptotic process. This specific gene exhibits a log2 fold change of 6.339 and an adjusted p-value of 0.0003037. Which protein is encoded by this gene? | Protein BEX2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08309","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in the regulation ... | |
medium_hidden_intermediate_08310 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Axon guidance. Experimental data for this gene reports a log2 fold change of -1.247 and an adjusted p-value of 0.01058. Which protein is encoded by this gene? | LIM/homeobox protein Lhx9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08310","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Axon guidance. Experime... | |
medium_hidden_intermediate_08311 | Zika virus downregulates a gene that interacts with RPAP2. Evidence for this intermediate gene reports a log2 fold change of -3.009 and an adjusted p-value of 0.02034. Which cell type is this intermediate gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08311","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with RPAP2. Evidence for this intermediate gene reports a log2 fold change of... | |
medium_hidden_intermediate_08313 | Human alphaherpesvirus 1 upregulates a specific gene product that participates in the Adaptive Immune System. Transcriptomic data from a monocytic leukemia cell line (study GSE114966) indicates that this entity has a log2 fold change of approximately 2.225 and an adjusted p-value of 0.009326. Which protein is encoded b... | Histone H2B type 1-C/E/F/G/I | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08313","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a specific gene product that participates in the Adaptive Immune System. Transcriptomic... | |
medium_hidden_intermediate_08314 | A gene is downregulated by Zika virus and enables zinc ion binding. Experimental data for this gene reports a log2 fold change of -1.637 and an adjusted p-value of 0.03777. Which disease is associated with this gene? | essential tremor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08314","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and enables zinc ion binding. Experimental data for this gene reports a log2 fold chan... | |
medium_hidden_intermediate_08315 | Pegivirus C is reported to downregulate a gene that participates in platelet activation, signaling, and aggregation. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.927 and an adjusted p-value of 0.01259. Which protein is encoded by this speci... | Diacylglycerol kinase gamma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08315","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in platelet activation, signaling, and aggregation. In a st... | |
medium_hidden_intermediate_08318 | Human betaherpesvirus 5 downregulates multiple genes that are located in the endoplasmic reticulum membrane. One such gene exhibits a log2 fold change of -1.131 and an adjusted p-value of 9.244e-06 in foreskin fibroblast cell lines. Which biological process is this specific gene involved in? | regulation of cholesterol transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08318","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates multiple genes that are located in the endoplasmic reticulum membrane. One such gene e... | |
medium_hidden_intermediate_08319 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the adenylate cyclase-activating G protein-coupled receptor signaling pathway. Evidence for this gene reports a log2 fold change of 4.939 and an adjusted p-value of 0.04609. Which disease is associated with this gene? | acidosis disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08319","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the adenylate cyclase-acti... | |
medium_hidden_intermediate_08321 | Human betaherpesvirus 5 upregulates a gene that participates in the transport of small molecules. Evidence for this gene reports a log2 fold change of 1.015 and an adjusted p-value of 6.468e-05. Which cell type is this gene enriched in? | conventional dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08321","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the transport of small molecules. Evidence for this gene rep... | |
medium_hidden_intermediate_08324 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and enriched in eosinophils. Evidence for this gene reports a log2 fold change of approximately 1.705 and an adjusted p-value of 0.0405. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08324","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and enriched in... | |
medium_hidden_intermediate_08325 | Measles morbillivirus upregulates a gene that is located in chromatin. Evidence for one such gene reports a log2 fold change of 1.885 and an adjusted p-value of 0.01152. Which disease is associated with genomic alterations in that specific gene? | Hirschsprung disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08325","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is located in chromatin. Evidence for one such gene reports a log2 fold change... | |
medium_hidden_intermediate_08326 | Pegivirus C is known to downregulate certain genes, which in turn participate in cellular responses to stimuli. One such gene exhibits a log2 fold change of -1.490 and an adjusted p-value of 0.0001748 in peripheral blood mononuclear cells (study GSE131504). Which protein does this specific gene product bind to? | SZT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08326","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is known to downregulate certain genes, which in turn participate in cellular responses to stimuli. One such gen... | |
medium_hidden_intermediate_08327 | Two genes are each upregulated by Human immunodeficiency virus 1 and associated with glioma. One of these genes exhibits a log2 fold change of 1.621 and an adjusted p-value of 0.009497 in macrophages (study GSE108897). Which gene is this, and what protein does it bind to? | SHH | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08327","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Human immunodeficiency virus 1 and associated with glioma. One of these genes exhibits a l... | |
medium_hidden_intermediate_08328 | Zika virus downregulates a gene that interacts with UNC93B1. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.145 and an adjusted p-value of 0.04764. Which protein is encoded by this gene? | Protein SAAL1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08328","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with UNC93B1. In a study of glioma stem cells (GSE114907), one such gene exhi... | |
medium_hidden_intermediate_08330 | Two genes are structurally linked from Vaccinia virus (via upregulation) to SARS-CoV Infections (via participation). One of these genes is associated with a log2 fold change of 1.696 and an adjusted p-value of 6.901e-05 in a cervical adenocarcinoma cell line study (GSE11238). Which gene is connected to this specific en... | TOMM70 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08330","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Vaccinia virus (via upregulation) to SARS-CoV Infections (via participation). One of ... | |
medium_hidden_intermediate_08331 | Human betaherpesvirus 5 upregulates a gene that subsequently binds to GNAT3. Experimental data for this intermediate gene reports a log2 fold change of 1.075 and an adjusted p-value of 0.0001469. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08331","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that subsequently binds to GNAT3. Experimental data for this intermediate gene re... | |
medium_hidden_intermediate_08332 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. This gene exhibited a log2 fold change of approximately -2.77 and an adjusted p-value of 0.011. What molecular functi... | ubiquitin protein ligase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08332","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that is invo... | |
medium_hidden_intermediate_08333 | Pegivirus C downregulates a gene that is located in the extracellular region. Evidence for this gene in peripheral blood mononuclear cells (study GSE131504) reports a log2 fold change of approximately -2.94 and an adjusted p-value of approximately 0.00012. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08333","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that is located in the extracellular region. Evidence for this gene in peripheral blood mon... | |
medium_hidden_intermediate_08334 | Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to the negative regulation of cold-induced thermogenesis via an involvement relationship. One of these genes is associated with experimental data showing a log2 fold change of 1.031 and an adjusted p-value of 0.0056... | PCTP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08334","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to the negative reg... | |
medium_hidden_intermediate_08335 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables G protein-coupled receptor activity. Experimental data for this gene reports a log2 fold change of -1.057 and an adjusted p-value of 0.006619. Which protein is encoded by this gene? | Leucine-rich repeat-containing G-protein coupled receptor 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08335","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables G protein-coupled receptor acti... | |
medium_hidden_intermediate_08336 | Human immunodeficiency virus 1 upregulates a gene that is associated with lymphoma. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 2.459 and an adjusted p-value of 5.531e-05. Which protein is encoded by this gene? | Alpha-internexin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08336","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with lymphoma. Evidence for this gene in macrophages (f... | |
medium_hidden_intermediate_08337 | Pegivirus C is reported to downregulate a gene that is involved in the cell surface receptor signaling pathway. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this specific gene has a log2 fold change of approximately -3.38 and an adjusted p-value of 0.0056. Which protei... | C-type lectin domain family 2 member D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08337","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the cell surface receptor signaling pathway. Experimental... | |
medium_hidden_intermediate_08338 | A gene is downregulated by Primate bocaparvovirus 1 and is enriched in eosinophils. Transcriptomic data for this gene reports a log2 fold change of -1.301 and an adjusted p-value of 0.005103. Which protein is encoded by this gene? | Protein FAM219B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08338","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is enriched in eosinophils. Transcriptomic data for this gene report... | |
medium_hidden_intermediate_08340 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in ABC-family protein mediated transport. Evidence for this gene reports a log2 fold change of 1.798 and an adjusted p-value of 0.04323. Which protein is encoded by this gene? | ATP-binding cassette sub-family C member 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08340","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in ABC-family protein mediated tr... | |
medium_hidden_intermediate_08342 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with LRRC59. One of these genes shows a log2 fold change of 1.324 and an adjusted p-value of 0.000803 in lung cells. Which protein is encoded by this specific gene? | Regulator of microtubule dynamics protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08342","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with LRRC59. One of these ge... | |
medium_hidden_intermediate_08343 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection upregulates a specific gene that encodes a protein located in a protein-containing complex. This gene exhibits a log2 fold change of 2.111 and an adjusted p-value of 2.414e-12. Which biological process is this gene involved in? | endocytic recycling | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08343","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection upregulates a specific gene that encodes a ... | |
medium_hidden_intermediate_08344 | Two genes are downregulated by Human immunodeficiency virus 1 and interact with CUL3. One of these genes exhibits a log2 fold change of -1.648 and an adjusted p-value of 0.007433 in a specific study. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08344","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and interact with CUL3. One of these genes exhibits a log2 fol... | |
medium_hidden_intermediate_08345 | Rhinovirus A downregulates a specific gene that enables DNA-binding transcription repressor activity, RNA polymerase II-specific. In a study of cytotoxic T-lymphocytes (GSE106475), this gene exhibited a log2 fold change of approximately -2.18 and an adjusted p-value of 0.003. Which disease is associated with this gene? | mammary neoplasms, animal | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08345","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A downregulates a specific gene that enables DNA-binding transcription repressor activity, RNA polymerase II-spec... | |
medium_hidden_intermediate_08347 | Pegivirus C downregulates a specific gene that enables mRNA binding. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) show a log2 fold change of -1.908 and an adjusted p-value of 0.0007217. Which biological process is this gene involved in? | regulation of intracellular mRNA localization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08347","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene that enables mRNA binding. Experimental data for this gene in peripheral blood mon... | |
medium_hidden_intermediate_08348 | Zika virus upregulates a gene that participates in Cytokine Signaling in the Immune system. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately 1.99 and an adjusted p-value of approximately 0.0064. Which protein is encoded by this gene? | Growth-regulated alpha protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08348","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in Cytokine Signaling in the Immune system. Evidence for this gene in glioma... | |
medium_hidden_intermediate_08349 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to SLX4 via an 'interacts with' relationship. One of these genes has been reported in a study (GSE148729) using a colonic adenocarcinoma cell line, with a log2 fold change of -1.274 and an a... | Probable ATP-dependent RNA helicase DHX40 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08349","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_08354 | Triprolidine and Mepyramine are linked via a shared interacting partner. Evidence indicates that the uptake of [3H]mepyramine and [14C]epinastine by RBEC1 cells was inhibited by organic cations including quinidine, the shared partner, and verapamil, but not by tetraethyl ammonium, guanidine, or carnitine. Which disease... | swine influenza | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08354","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Triprolidine and Mepyramine are linked via a shared interacting partner. Evidence indicates that the uptake of [3H]mepyramin... | |
medium_hidden_intermediate_08358 | Human alphaherpesvirus 1 upregulates a gene that is located in the centrosome. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibited a log2 fold change of 1.579 and an adjusted p-value of 0.03081. Which biological process is this specific gene involved in? | negative regulation of cilium assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08358","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is located in the centrosome. In a study of monocytic leukemia cell lines (... | |
medium_hidden_intermediate_08359 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the metabolism of folate and pterines. Evidence for one such gene reports a log2 fold change of 1.085 and an adjusted p-value of 0.0002868. Which protein is encoded by that gene? | Solute carrier family 25 member 32 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08359","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the metabolism of folate and p... | |
medium_hidden_intermediate_08360 | Two distinct drugs are known to interact with both Trospium and Larotrectinib. Clinical evidence regarding one of these drugs describes its use (at doses of 25/50 mg) in combination with anticholinergic agents, specifically listing solifenacin, tolterodine, trospium, and the drug in question itself. Which disease is th... | overactive bladder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08360","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are known to interact with both Trospium and Larotrectinib. Clinical evidence regarding one of these drug... | |
medium_hidden_intermediate_08364 | Human betaherpesvirus 5 is reported to upregulate a gene that is enriched in basophils. Among the genes fitting this structural description, one exhibits a log2 fold change of 1.806 and an adjusted p-value of 7.682e-06 in foreskin fibroblast cell lines. Which disease is associated with this specific gene as a biomarker... | pulmonary hypertension | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08364","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is enriched in basophils. Among the genes fitting this structu... | |
medium_hidden_intermediate_08365 | Pegivirus C is reported to downregulate a specific gene that enables kinase binding. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) show a log2 fold change of -1.826 and an adjusted p-value of 9.429e-05. Which disease is associated with this gene? | hypothyroidism | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08365","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that enables kinase binding. Experimental data for this gene in peri... | |
medium_hidden_intermediate_08366 | In a study of Human alphaherpesvirus 1 infection in a monocytic leukemia cell line (GSE114966), two genes are upregulated by the virus and known to bind UBE2F. One of these genes exhibits a log2 fold change of approximately 1.087 and an adjusted p-value of 0.02181. What molecular function is enabled by this specific ge... | ubiquitin-like ligase-substrate adaptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08366","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Human alphaherpesvirus 1 infection in a monocytic leukemia cell line (GSE114966), two genes are upregulated by... | |
medium_hidden_intermediate_08368 | Human betaherpesvirus 5 upregulates a gene that participates in TRAIL signaling. Evidence for one such gene reports a log2 fold change of 1.138 and an adjusted p-value of 0.03675. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08368","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in TRAIL signaling. Evidence for one such gene reports a log2 f... | |
medium_hidden_intermediate_08370 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and participates in Rab regulation of trafficking. This gene exhibits a log2 fold change of 1.209 and an adjusted p-value of 1.48e-06. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08370","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and p... | |
medium_hidden_intermediate_08371 | Pegivirus C is reported to downregulate a gene that is involved in reticulophagy. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.455 and an adjusted p-value of 0.004191. Which protein is encoded by this specific gene? | Cell cycle progression protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08371","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in reticulophagy. In a study of peripheral blood mononuclear... | |
medium_hidden_intermediate_08372 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with acute leukemia. One of these genes exhibits a log2 fold change of approximately 2.32 and an adjusted p-value of 0.0237 in a specific study. Which cellular component is the location of this specific gene? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08372","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with acute leukemia. O... | |
medium_hidden_intermediate_08373 | Pegivirus C is reported to downregulate a gene that is located in the synapse. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of -1.788 and an adjusted p-value of 0.003229. Which protein is encoded by this specific gene? | Beta-chimaerin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08373","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the synapse. In a study of peripheral blood mononuclear ce... | |
medium_hidden_intermediate_08376 | Zika virus downregulates a gene that is located in chromatin. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -2.725 and an adjusted p-value of 0.004226. Which protein is encoded by this gene? | Importin-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08376","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in chromatin. In a study of glioma stem cells (GSE114907), this gene exhibit... | |
medium_hidden_intermediate_08377 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene, which is also implicated in infectious disease. This gene exhibited a log2 fold change of -1.885 and an adjusted p-value of 0.03199. What molecular function is enabled by this gene? | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08377","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_08378 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to RAB1B. This specific gene exhibits a log2 fold change of 2.092 and an adjusted p-value of 0.000235. Which protein is encoded by this gene? | CD59 glycoprotein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08378","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to RAB1B. Thi... | |
medium_hidden_intermediate_08379 | In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequently interacts with DYRK1B. Experimental data for this gene reports a log2 fold change of approximately 1.197 and an adjusted p-value of 0.02716. Which protein is encoded by this gene? | Protein phosphatase 1 regulatory subunit 3F | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08379","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subseq... | |
medium_hidden_intermediate_08380 | Hepacivirus C upregulates a gene that is involved in the ceramide metabolic process. Experimental data for one such gene reports a log2 fold change of 2.193 and an adjusted p-value of 0.04391. Which protein is encoded by this gene? | Neutral ceramidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08380","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the ceramide metabolic process. Experimental data for one such gene rep... | |
medium_hidden_intermediate_08381 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that enables manganese ion binding. This gene exhibited a log2 fold change of -1.666 and an adjusted p-value of 0.002264. Which protein is encoded by this gene? | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08381","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that enables... | |
medium_hidden_intermediate_08382 | Human immunodeficiency virus 1 upregulates a gene that participates in the post-translational modification process of synthesizing GPI-anchored proteins. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately 1.548 and an adjusted p-value of 0.02774. Which protein is encoded ... | Limbic system-associated membrane protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08382","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the post-translational modification process of synthe... | |
medium_hidden_intermediate_08384 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enables enzyme binding. This specific gene exhibits a log2 fold change of approximately -1.13 and an adjusted p-value of 0.0016. Which disease is associated with this gene? | teratocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08384","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enab... | |
medium_hidden_intermediate_08386 | Zika virus downregulates a gene that is involved in actin cytoskeleton organization. Evidence for this gene reports a log2 fold change of -1.938 and an adjusted p-value of 0.004134. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08386","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in actin cytoskeleton organization. Evidence for this gene reports a log2 f... | |
medium_hidden_intermediate_08387 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to PPL via a 'binds' relationship. One of these genes is associated with a log2 fold change of 2.314 and an adjusted p-value of 0.01085 in bronchial epithelial cells. Which disease is connect... | polyarticular arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08387","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_08388 | Hepacivirus C upregulates a gene that enables guanyl-nucleotide exchange factor activity. Experimental data for this gene in hepatocytes (study GSE132606) reports a log2 fold change of approximately 2.82 and an adjusted p-value of 0.0023. Which protein is encoded by this gene? | Myotubularin-related protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08388","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables guanyl-nucleotide exchange factor activity. Experimental data for this gene in... | |
medium_hidden_intermediate_08389 | In a study of bronchial epithelial cells (GSE147507), Influenza A virus infection was found to downregulate a gene involved in the ethanol catabolic process. One such gene exhibited a log2 fold change of -1.229 and an adjusted p-value of 8.553e-05. Which protein is encoded by this specific gene? | Sulfotransferase 1E1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08389","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells (GSE147507), Influenza A virus infection was found to downregulate a gene involved ... | |
medium_hidden_intermediate_08390 | In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that is involved in the phospholipase C-activating G protein-coupled receptor signaling pathway. This specific gene exhibited a log2 fold change of 1.254 and an adjusted p-value of 0.03189. Which... | PLPP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08390","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene... | |
medium_hidden_intermediate_08391 | Human immunodeficiency virus 1 downregulates a gene that is located in the lysosome. Evidence for this gene reports a log2 fold change of -2.246 and an adjusted p-value of 0.009641. Which cell type is this gene enriched in? | intermediate monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08391","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the lysosome. Evidence for this gene reports a log2 f... | |
medium_hidden_intermediate_08393 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to the Assembly of the 9+0 primary cilium via a participation relationship. One of these genes is associated with experimental data showing a log2 fold change of 1.931 and an adjusted p-value ... | PMCH | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08393","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_08394 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of specific genes involved in stress granule assembly. One such gene exhibits a log2 fold change of -2.199 and an adjusted p-value of 0.01115. Which protein is encoded by this specific gene? | DAZ-associated protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08394","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of specific gen... | |
medium_hidden_intermediate_08395 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in biological oxidations. One such gene exhibits a log2 fold change of approximately 2.89 and an adjusted p-value of approximately 0.023. Which cellular component is this specific gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08395","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in biological oxi... | |
medium_hidden_intermediate_08397 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables GTPase activity. Transcriptomic data for this gene in sclera tissue shows a log2 fold change of approximately 1.03 and an adjusted p-value of 0.0163. Which disease is associated with this gene? | cocaine dependence | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08397","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables GTPase activity. Transcriptomic d... | |
medium_hidden_intermediate_08398 | Hepacivirus C upregulates a gene that participates in the RAF/MAP kinase cascade. Evidence for one such gene reports a log2 fold change of 1.637 and an adjusted p-value of 0.001763. Which protein is encoded by that gene? | Dual specificity protein phosphatase 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08398","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the RAF/MAP kinase cascade. Evidence for one such gene reports a log2 ... | |
medium_hidden_intermediate_08399 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that enable zinc ion binding. One such gene exhibits a log2 fold change of -1.045 and an adjusted p-value of 0.0408. Which protein is encoded by this specific gene? | Methionine-R-sulfoxide reductase B2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08399","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that ... | |
medium_hidden_intermediate_08401 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in fatty acid beta-oxidation. One of these genes exhibits a log2 fold change of 1.277 and an adjusted p-value of 0.007434 in a specific study. Which cellular component is the location of this specific gene? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08401","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in fatty acid beta-oxida... | |
medium_hidden_intermediate_08403 | Zika virus downregulates a gene that participates in SRP-dependent cotranslational protein targeting to the membrane. In glioma stem cells, this gene exhibits a log2 fold change of -1.839 and an adjusted p-value of 0.01008. Which biological process is this gene involved in? | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08403","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in SRP-dependent cotranslational protein targeting to the membrane. In gli... | |
medium_hidden_intermediate_08404 | Human betaherpesvirus 5 is reported to upregulate a gene that is associated with multiple sclerosis. In a specific study involving foreskin fibroblast cell lines, this gene exhibited a log2 fold change of approximately 1.632 and an adjusted p-value of 0.001083. Which protein is encoded by this gene? | Mitochondrial glutamate carrier 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08404","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is associated with multiple sclerosis. In a specific study inv... | |
medium_hidden_intermediate_08405 | Severe acute respiratory syndrome-related coronavirus downregulates a specific gene, which in turn interacts with EIF2S2. Experimental data for this intermediate gene reports a log2 fold change of approximately -1.46 and an adjusted p-value of 0.0427. Which protein is encoded by this gene? | Eukaryotic translation initiation factor 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08405","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a specific gene, which in turn interacts with EIF2S2. Ex... | |
medium_hidden_intermediate_08406 | Zaire ebolavirus downregulates a gene that is located in the Golgi membrane. Evidence for this gene reports a log2 fold change of -1.032 and an adjusted p-value of 0.004466. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08406","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that is located in the Golgi membrane. Evidence for this gene reports a log2 fold chan... | |
medium_hidden_intermediate_08408 | A gene is upregulated by Zika virus and located in the extracellular exosome. Evidence for this gene reports a log2 fold change of 1.113 and an adjusted p-value of 0.0301. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08408","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Zika virus and located in the extracellular exosome. Evidence for this gene reports a log2 fold cha... | |
medium_hidden_intermediate_08409 | Two genes are downregulated by Vaccinia virus and participate in cell-cell junction organization. One of these genes exhibits a log2 fold change of approximately -1.04 and an adjusted p-value of 0.0012 in cervical adenocarcinoma cells. In which cellular component is this specific gene located? | Golgi membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08409","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Vaccinia virus and participate in cell-cell junction organization. One of these genes exhibit... | |
medium_hidden_intermediate_08410 | A gene is downregulated by Human gammaherpesvirus 8 and enriched in classical monocytes. Experimental data for this gene in umbilical vein endothelial cells (study GSE119608) reports a log2 fold change of approximately -1.36 and an adjusted p-value of 0.0124. Which biological process is this gene involved in? | lysosome fission | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08410","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and enriched in classical monocytes. Experimental data for this gene in ... | |
medium_hidden_intermediate_08412 | Measles morbillivirus upregulates a gene that participates in GPCR downstream signalling. Evidence for this gene reports a log2 fold change of 1.076 and an adjusted p-value of 0.04715. Which protein is encoded by this gene? | Monoacylglycerol lipase ABHD6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08412","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in GPCR downstream signalling. Evidence for this gene reports a l... | |
medium_hidden_intermediate_08415 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes involved in rRNA processing. One such gene exhibited a log2 fold change of approximately 1.92 and an adjusted p-value of approximately 4.60e-06. Which protein is encoded by this specific gene? | Mitochondrial ribonuclease P catalytic subunit | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08415","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_08416 | Hepacivirus C upregulates a gene that participates in glycerophospholipid biosynthesis. In a study of hepatocytes (GSE132606), one such gene showed a log2 fold change of 1.132 and an adjusted p-value of 0.00923. Which disease is associated with this specific gene? | alpha 1-antitrypsin deficiency | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08416","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in glycerophospholipid biosynthesis. In a study of hepatocytes (GSE132606... | |
medium_hidden_intermediate_08417 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in O-linked glycosylation. Experimental data for this gene in lung tissue from study GSE148697 reports a log2 fold change of 2.539 and an adjusted p-value of 0.01704. Which disease is associated with this gene? | proteinuria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08417","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in O-linked glycosylation. E... | |
medium_hidden_intermediate_08418 | In a study of macrophages (GSE108897), a gene is downregulated by Human immunodeficiency virus 1 and binds to RFC2. This gene exhibits a log2 fold change of -2.971 and an adjusted p-value of 0.003221. Which protein is encoded by this gene? | Sister chromatid cohesion protein DCC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08418","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is downregulated by Human immunodeficiency virus 1 and binds to RFC2. This gen... | |
medium_hidden_intermediate_08423 | Hepacivirus C downregulates a gene that participates in the Immune System. In a study of peripheral blood mononuclear cells (GSE119117), one such gene showed a log2 fold change of -1.366 and an adjusted p-value of 0.000461. Which protein is encoded by this gene? | Kinesin light chain 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08423","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that participates in the Immune System. In a study of peripheral blood mononuclear cells ... | |
medium_hidden_intermediate_08424 | Zika virus downregulates a gene that interacts with CEP135. In glioma stem cells, one such downregulated gene exhibits a log2 fold change of approximately -1.73 and an adjusted p-value of 0.0156. Which protein is encoded by this specific gene? | Coiled-coil domain-containing protein 77 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08424","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with CEP135. In glioma stem cells, one such downregulated gene exhibits a log... | |
medium_hidden_intermediate_08425 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enables calcium ion binding. This specific gene exhibits a log2 fold change of approximately -1.65 and an adjusted p-value of 0.02119. Which biological process is this gene involved in? | endothelial cell migration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08425","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enab... | |
medium_hidden_intermediate_08426 | Two genes are downregulated by Human immunodeficiency virus 1 and interact with PRKN. One of these genes exhibits a log2 fold change of -1.321 and an adjusted p-value of 0.01929 in macrophages. Which disease is associated with this specific gene as a biomarker? | bipolar disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08426","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and interact with PRKN. One of these genes exhibits a log2 fol... | |
medium_hidden_intermediate_08427 | Two genes are identified as markers of ionocytes and are also associated with breast cancer as biomarkers. One of these genes is described in the literature as a promising therapeutic target for breast cancer. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08427","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers of ionocytes and are also associated with breast cancer as biomarkers. One of these gene... | |
medium_hidden_intermediate_08428 | Human immunodeficiency virus 1 upregulates a gene that participates in the RHOA GTPase cycle. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately 1.137 and an adjusted p-value of 0.000617. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08428","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the RHOA GTPase cycle. Evidence for this gene in macr... | |
medium_hidden_intermediate_08429 | A gene is upregulated by Vaccinia virus and enables mRNA binding. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 1.313 and an adjusted p-value of 0.006149. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08429","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and enables mRNA binding. Experimental data for this gene in a cervical adenocarcino... | |
medium_hidden_intermediate_08431 | Chronic hepatitis B virus infection is localized to a specific anatomical entity, which is a type of haemolymphatic fluid. Evidence indicates that this entity is a fluid composed of itself and erythrocytes. Which anatomical system is this entity a part of? | hematopoietic system | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08431","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Chronic hepatitis B virus infection is localized to a specific anatomical entity, which is a type of haemolymphatic fluid. E... | |
medium_hidden_intermediate_08432 | Human immunodeficiency virus 1 downregulates a gene that is involved in intracellular protein localization. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of -1.412 and an adjusted p-value of 0.03761. Which protein is encoded by this gene? | Coiled-coil domain-containing protein 68 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08432","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in intracellular protein localization. Evidence for thi... | |
medium_hidden_intermediate_08433 | Two genes are upregulated by Vaccinia virus and interact with CLPP. One of these genes shows a log2 fold change of 1.282 and an adjusted p-value of 4.865e-08 in cervical adenocarcinoma cell lines. Which disease is associated with genomic alterations in this specific gene? | infantile spasms | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08433","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with CLPP. One of these genes shows a log2 fold change of 1.282 and... | |
medium_hidden_intermediate_08435 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein tyrosine phosphatase activity. Experimental data for this gene shows a log2 fold change of 2.546 and an adjusted p-value of 0.01108. Which biological process is this gene involved in? | protein dephosphorylation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08435","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein tyrosine phosphatase acti... | |
medium_hidden_intermediate_08436 | Measles morbillivirus upregulates a gene that interacts with BAP1. One such gene exhibits a log2 fold change of 1.019 and an adjusted p-value of 4.207e-05 in pleural mesothelioma cells. Which protein is encoded by this gene? | Ribose-phosphate pyrophosphokinase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08436","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with BAP1. One such gene exhibits a log2 fold change of 1.019 and an... | |
medium_hidden_intermediate_08437 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which is involved in the negative regulation of cold-induced thermogenesis. This gene exhibited a log2 fold change of -1.057 and an adjusted p-value of 0.006619. Which ce... | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08437","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_08438 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in G alpha (i) signalling events. This gene exhibits a log2 fold change of approximately 3.33 and an adjusted p-value of approximately 1.79e-07. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08438","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in... | |
medium_hidden_intermediate_08439 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of RNA splicing. Evidence for this gene shows a log2 fold change of approximately 1.26 and an adjusted p-value of approximately 0.0095. Which gene interacts with this upregulated gene? | UBL5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08439","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of RNA splicing.... | |
medium_hidden_intermediate_08440 | Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to P-body via a 'located in' relationship. One of these genes has an associated experimental record showing a log2 fold change of -1.116 and an adjusted p-value of 0.01485. Which cell type is this specific gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08440","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to P-body via a 'located in' relat... | |
medium_hidden_intermediate_08443 | Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the positive regulation of endothelial cell migration. In a study using foreskin fibroblast cell lines, one such gene exhibited a log2 fold change of -2.124 and an adjusted p-value of 2.612e-05. Which protein is encoded by this specific gene... | Annexin A3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08443","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the positive regulation of endothelial cell m... | |
medium_hidden_intermediate_08444 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in lipid metabolic process. Experimental data for this gene shows a log2 fold change of approximately 1.078 and an adjusted p-value of 0.0003314. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08444","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in lipid metabolic process. E... | |
medium_hidden_intermediate_08445 | Rhinovirus A upregulates a specific gene, which in turn interacts with CANX. Experimental data for this gene in cytotoxic T-lymphocytes (study GSE106475) reports a log2 fold change of approximately 1.029 and an adjusted p-value of approximately 0.000478. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08445","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A upregulates a specific gene, which in turn interacts with CANX. Experimental data for this gene in cytotoxic T-... | |
medium_hidden_intermediate_08446 | Zika virus downregulates a gene that enables DNA-binding transcription activator activity, RNA polymerase II-specific. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.572 and an adjusted p-value of 0.03778. Which protein is encoded by this gene? | Myb-related protein A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08446","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables DNA-binding transcription activator activity, RNA polymerase II-specific. In a ... | |
medium_hidden_intermediate_08450 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene was found to be downregulated and is involved in the antibacterial humoral response. Evidence for this gene reports a log2 fold change of approximately -1.95 and an adjusted p-value of 0.047. Which protein is e... | Ribonuclease 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08450","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene was found to b... | |
medium_hidden_intermediate_08453 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both bind to STX1A. One of these genes exhibits a log2 fold change of 2.443 and an adjusted p-value of 1.234e-06 in a specific study. Which disease is associated with this specific gene? | PPFIA3-related neurodevelopmental disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08453","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both bind to STX1A. One of these gene... | |
medium_hidden_intermediate_08455 | Zika virus downregulates a gene that is associated with kidney cancer. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -3.97 and an adjusted p-value of 0.0155. Which protein is encoded by this gene? | Hypoxia-inducible lipid droplet-associated protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08455","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is associated with kidney cancer. Evidence for this gene in glioma stem cells (study GS... |
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