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medium_hidden_intermediate_08456 | In a study of non-small cell lung adenocarcinoma, Influenza A virus infection was found to upregulate a gene that enables protein serine/threonine kinase activity. This specific gene exhibited a log2 fold change of approximately 1.106 and an adjusted p-value of 7.757e-08. Which protein is encoded by this gene? | Serine/threonine-protein kinase 38-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08456","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma, Influenza A virus infection was found to upregulate a gene that enables pr... | |
medium_hidden_intermediate_08457 | Human alphaherpesvirus 1 upregulates a gene that participates in metabolism. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibited a log2 fold change of 1.228 and an adjusted p-value of 0.002083. Which protein interacts with this specific gene product? | PRKN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08457","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in metabolism. In a study of monocytic leukemia cell lines (GS... | |
medium_hidden_intermediate_08459 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate certain genes that participate in diseases of glycosylation. One such gene exhibited a log2 fold change of approximately -1.80 and an adjusted p-value of approximately 0.011. Which protein is encoded by this specific gen... | ADAMTS-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08459","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate certain genes that parti... | |
medium_hidden_intermediate_08460 | Two genes are downregulated by Pegivirus C and enriched in memory B cells. One of these genes exhibits a log2 fold change of -1.996 and an adjusted p-value of 0.01259 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | primary biliary cholangitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08460","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and enriched in memory B cells. One of these genes exhibits a log2 fold change of... | |
medium_hidden_intermediate_08461 | Human alphaherpesvirus 1 is reported to downregulate a specific gene, which is in turn enriched in naive CD4+ T cells. In a study of monocytic leukemia cell lines (GSE114966), this gene exhibited a log2 fold change of approximately -1.007 and an adjusted p-value of 0.002075. Which protein is encoded by this gene? | Adenylate kinase isoenzyme 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08461","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is reported to downregulate a specific gene, which is in turn enriched in naive CD4+ T cells. In a ... | |
medium_hidden_intermediate_08463 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Fatty acid metabolism. Experimental data for this gene in lung cells reports a log2 fold change of 1.317 and an adjusted p-value of 0.01796. Which biological process is this gene involved in? | unsaturated fatty acid biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08463","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Fatty acid metabolism. Ex... | |
medium_hidden_intermediate_08464 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in cellular responses to stimuli. Experimental data for this gene reports a log2 fold change of approximately 1.347 and an adjusted p-value of 8.269e-08. Which protein is encoded by this gene? | S-adenosylmethionine sensor upstream of mTORC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08464","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in cellular response... | |
medium_hidden_intermediate_08465 | Human immunodeficiency virus 1 upregulates a gene that participates in diseases of metabolism. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of 2.180 and an adjusted p-value of 0.0006004. Which protein is encoded by this gene? | A disintegrin and metalloproteinase with thrombospondin motifs 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08465","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in diseases of metabolism. In a study of macrophages (GS... | |
medium_hidden_intermediate_08466 | Hepacivirus C upregulates a gene that is located in the organelle membrane. Evidence for one such gene reports a log2 fold change of 1.565 and an adjusted p-value of 0.04629. Which protein is encoded by that gene? | Microtubule-associated protein 1 light chain 3 alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08466","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is located in the organelle membrane. Evidence for one such gene reports a log2 fold c... | |
medium_hidden_intermediate_08467 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that participates in G alpha (q) signalling events. One such gene exhibited a log2 fold change of 1.422 and an adjusted p-value of 0.0003768. Which protein is encoded by this specifi... | Gastrin/cholecystokinin type B receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08467","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upre... | |
medium_hidden_intermediate_08469 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the metabolism of steroids. Evidence for this gene reports a log2 fold change of 1.077 and an adjusted p-value of 3.958e-06. Which protein is encoded by this gene? | Protein transport protein Sec24A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08469","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the metabolism of steroids. Ev... | |
medium_hidden_intermediate_08472 | Pegivirus C is reported to downregulate a specific gene that participates in the epigenetic regulation of gene expression. In a study (GSE131504) involving peripheral blood mononuclear cells, this gene exhibited a log2 fold change of approximately -2.246 and an adjusted p-value of 0.002444. Which cell type is this gene... | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08472","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that participates in the epigenetic regulation of gene expression. I... | |
medium_hidden_intermediate_08473 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that enables adenine transmembrane transporter activity. One such gene exhibited a log2 fold change of 4.693 and an adjusted p-value of 1.013e-10. Which protein is encoded by this specific gene? | Equilibrative nucleobase transporter 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08473","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that en... | |
medium_hidden_intermediate_08474 | Rhinovirus A infection is associated with the downregulation of specific genes, some of which are enriched in non-classical monocytes. One such gene exhibits a log2 fold change of approximately -1.20 and an adjusted p-value of 0.012 in cytotoxic T-lymphocytes. Which protein is encoded by this gene? | Cysteine/serine-rich nuclear protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08474","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the downregulation of specific genes, some of which are enriched in non-classical ... | |
medium_hidden_intermediate_08475 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in nuclear events involving kinase and transcription factor activation. This gene exhibits a log2 fold change of approximately 1.51 and an adjusted p-value of approximately 0.0032. In which cell type is this gene enr... | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08475","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in nuclear events in... | |
medium_hidden_intermediate_08476 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with chondrosarcoma. One of these genes exhibits a log2 fold change of -2.649 and an adjusted p-value of 0.0006686 in a specific study. Which protein is encoded by this gene? | Differentially expressed in FDCP 6 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08476","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with chondrosarcoma.... | |
medium_hidden_intermediate_08478 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Rab regulation of trafficking. Evidence for one such gene reports a log2 fold change of 1.495 and an adjusted p-value of 3.828e-07. Which protein is encoded by that gene? | DENN domain-containing protein 2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08478","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Rab regulation of trafficking.... | |
medium_hidden_intermediate_08479 | Two cell types are structurally linked to the IgM immunoglobulin complex via the plasma membrane and express CD38. One of these entities is described as an intermediate stage between the pre-B cell stage and the mature naive stage, characterized by a surface IgM-positive and CD19-positive phenotype, and is subject to B... | immature B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08479","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two cell types are structurally linked to the IgM immunoglobulin complex via the plasma membrane and express CD38. One of th... | |
medium_hidden_intermediate_08480 | Enterovirus A is known to upregulate a specific gene that is involved in the regulation of DNA-templated transcription. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2 fold change of approximately 1.47 and an adjusted p-value of approximately 0.0126. Which disease is associated with this ge... | gastric carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08480","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is known to upregulate a specific gene that is involved in the regulation of DNA-templated transcription. In a... | |
medium_hidden_intermediate_08481 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of these genes exhibits a log2 fold change of approximately 1.67 and an adjusted p-value of approximately 0.0069 in a specific study. Which disease is linked to this specific gene through genomic alter... | hypertensive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08481","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of th... | |
medium_hidden_intermediate_08482 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of certain genes, which in turn encode proteins that bind to GNAT3. One such gene exhibits a log2 fold change of approximately 6.81 and an adjusted p-value of 3.32e-06. Which protein is encoded by this specif... | C-C motif chemokine 25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08482","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of certain g... | |
medium_hidden_intermediate_08483 | In a study of rhabdomyosarcoma cells (GSE103308), a gene is downregulated by Enterovirus A and participates in diseases associated with glycosaminoglycan metabolism. This specific gene exhibits a log2 fold change of approximately -2.258 and an adjusted p-value of 0.03705. Which protein is encoded by this gene? | Osteomodulin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08483","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), a gene is downregulated by Enterovirus A and participates in diseases asso... | |
medium_hidden_intermediate_08485 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with obesity disorder. One of these genes exhibits a log2 fold change of approximately 1.175 and an adjusted p-value of 0.0104 in lung cells. Which disease is linked to this specific gene via a biomarker relationship? | thyroid tumor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08485","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with obesity disorder.... | |
medium_hidden_intermediate_08486 | Two genes are structurally linked from Human immunodeficiency virus 1 to preeclampsia via a 'downregulates' relationship followed by an 'associated with' relationship. One of these genes exhibits a log2 fold change of -2.889 and an adjusted p-value of 0.01542 in a specific study context. Which cell type is that specifi... | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08486","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human immunodeficiency virus 1 to preeclampsia via a 'downregulates' relationship fol... | |
medium_hidden_intermediate_08487 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with UBE2E1. One of these genes shows a log2 fold change of 1.241 and an adjusted p-value of 0.004869 in a specific study. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase TRIM23 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08487","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with UBE2E1. One of these ge... | |
medium_hidden_intermediate_08488 | In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequently participates in the process where XBP1(S) activates chaperone genes. Experimental data for this gene in a cardiomyocyte cell line (study GSE162736) reports a log2 fold change of approximate... | Peptidyl-prolyl cis-trans isomerase FKBP14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08488","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subseq... | |
medium_hidden_intermediate_08489 | Pegivirus C is reported to downregulate a gene that is involved in the cell surface receptor signaling pathway. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) show a log2 fold change of approximately -1.65 and an adjusted p-value of approximately 0.011. Which protein is encoded ... | C-type lectin domain family 1 member A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08489","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the cell surface receptor signaling pathway. Experimental... | |
medium_hidden_intermediate_08490 | Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of cell growth. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 1.268 and an adjusted p-value of 2.226e-05. Which disease is associated with this gene? | urinary bladder carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08490","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of cell growth. Evidence for t... | |
medium_hidden_intermediate_08491 | Human betaherpesvirus 5 upregulates a gene that is enriched in non-classical monocytes. Evidence for this gene reports a log2 fold change of 2.097 and an adjusted p-value of 0.0233. Which protein does this gene interact with? | STAT3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08491","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is enriched in non-classical monocytes. Evidence for this gene reports a log... | |
medium_hidden_intermediate_08492 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of these genes exhibits a log2 fold change of 4.634 and an adjusted p-value of 4.111e-06 in a specific study. Which protein is encoded by this gene? | Activator of apoptosis harakiri | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08492","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of th... | |
medium_hidden_intermediate_08493 | Rhinovirus A infection leads to the downregulation of certain genes, which in turn encode proteins capable of identical protein binding. In a study of cytotoxic T-lymphocytes (GSE106475), one such gene exhibited a log2 fold change of -2.855 and an adjusted p-value of 0.0008914. Which protein is encoded by this specific... | Zinc finger protein 618 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08493","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain genes, which in turn encode proteins capable of identical prot... | |
medium_hidden_intermediate_08494 | Zika virus downregulates a gene that interacts with the androgen receptor (AR). In glioma stem cells, one such downregulated gene exhibits a log2 fold change of approximately -1.54 and an adjusted p-value of approximately 0.0297. Which protein is encoded by this specific gene? | Insulin-degrading enzyme | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08494","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with the androgen receptor (AR). In glioma stem cells, one such downregulated... | |
medium_hidden_intermediate_08497 | Zika virus infection leads to the downregulation of specific genes that enable DNA-binding transcription activator activity, RNA polymerase II-specific. In a study of glioma stem cells (GSE114907), one such downregulated gene exhibited a log2 fold change of -2.826 and an adjusted p-value of 0.008491. Which protein is e... | ETS domain-containing protein Elk-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08497","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of specific genes that enable DNA-binding transcription activator activity,... | |
medium_hidden_intermediate_08499 | Zika virus downregulates a gene that enables nucleic acid binding. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -3.048 and an adjusted p-value of 0.02946. Which protein is encoded by this specific gene? | EH domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08499","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables nucleic acid binding. In a study of glioma stem cells (GSE114907), one such gen... | |
medium_hidden_intermediate_08500 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with YWHAB. Experimental data for this gene in lung cells shows a log2 fold change of -2.013 and an adjusted p-value of 0.0009234. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08500","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with YWHAB. Experimental data... | |
medium_hidden_intermediate_08501 | Human betaherpesvirus 5 upregulates a gene that participates in the modulation of host responses by IFN-stimulated genes. Evidence for this gene in monocytes (study GSE11408) reports a log2 fold change of approximately 2.49 and an adjusted p-value of approximately 0.0336. Which protein is encoded by this gene? | Interferon-induced protein 44-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08501","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the modulation of host responses by IFN-stimulated genes. Ev... | |
medium_hidden_intermediate_08504 | Hepacivirus C upregulates a gene that is located in the perinuclear region of the cytoplasm. Experimental data for this gene in hepatocytes (study GSE132606) reports a log2 fold change of 2.374 and an adjusted p-value of 0.01375. Which biological process is this gene involved in? | negative regulation of receptor internalization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08504","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is located in the perinuclear region of the cytoplasm. Experimental data for this gene... | |
medium_hidden_intermediate_08505 | Measles morbillivirus upregulates a gene that is located in the extracellular region. Experimental data for one such gene reports a log2 fold change of 1.278 and an adjusted p-value of 0.01732. Which protein is encoded by this gene? | Gamma-interferon-inducible lysosomal thiol reductase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08505","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is located in the extracellular region. Experimental data for one such gene re... | |
medium_hidden_intermediate_08506 | In a study of rhabdomyosarcoma cells (GSE103308), a gene is downregulated by Enterovirus A and associated with lymphoma. This specific gene exhibits a log2 fold change of approximately -1.15 and an adjusted p-value of 0.00326. Which protein is encoded by this gene? | Noggin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08506","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), a gene is downregulated by Enterovirus A and associated with lymphoma. Thi... | |
medium_hidden_intermediate_08507 | Two genes are linked to Vaccinia virus via upregulation and to prostate cancer via biomarker association. One of these genes exhibits a log2 fold change of 2.271 and an adjusted p-value of 3.551e-11 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is encoded by the gene matching these statistical v... | High affinity copper uptake protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08507","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Vaccinia virus via upregulation and to prostate cancer via biomarker association. One of these genes... | |
medium_hidden_intermediate_08508 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated by the virus and participates in cellular responses to stimuli. This gene exhibits a log2 fold change of 1.374 and an adjusted p-value of 0.0213. Which biological process is this gene involved in? | cellular response to cadmium ion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08508","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated by the virus and pa... | |
medium_hidden_intermediate_08509 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the endosome membrane. Evidence for one such gene reports a log2 fold change of 1.105 and an adjusted p-value of 1.301e-10. Which protein is encoded by that gene? | Lysosome-associated membrane glycoprotein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08509","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the endosome membrane. Evidence ... | |
medium_hidden_intermediate_08510 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to stroke disorder via an association relationship. One of these genes exhibits a log2 fold change of approximately -1.88 and an adjusted p-value of approximately 0.0085 in macrophages from study GSE108897. Which p... | S-methylmethionine--homocysteine S-methyltransferase BHMT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08510","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to stroke disorder... | |
medium_hidden_intermediate_08514 | Two genes are structurally linked to Cardiovirus A via downregulation and to Signaling by Rho GTPases via participation. One of these genes exhibits a log2 fold change of -2.663 and an adjusted p-value of 0.03743 in a specific study. Which cell type is enriched for that specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08514","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via downregulation and to Signaling by Rho GTPases via participation. One... | |
medium_hidden_intermediate_08515 | Zika virus downregulates a specific gene that participates in Toll-like Receptor Cascades. In glioma stem cells (study GSE114907), this gene exhibits a log2 fold change of -1.985 and an adjusted p-value of 0.009902. Which biological process is this gene involved in? | negative regulation of canonical NF-kappaB signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08515","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in Toll-like Receptor Cascades. In glioma stem cells (study GSE11... | |
medium_hidden_intermediate_08516 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in cell differentiation. Evidence for one such gene reports a log2 fold change of 1.429 and an adjusted p-value of 0.008307. Which protein is encoded by that gene? | Zinc finger protein 808 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08516","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in cell differentiation. Evidence ... | |
medium_hidden_intermediate_08518 | PARP1 interacts with a protein that is located in the PML body. Evidence indicates that PARP-1 is a novel interacting partner of this specific protein. Which protein is encoded by the gene corresponding to this interacting partner? | E3 ubiquitin-protein ligase CHFR | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08518","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PARP1 interacts with a protein that is located in the PML body. Evidence indicates that PARP-1 is a novel interacting partne... | |
medium_hidden_intermediate_08519 | Two genes are structurally linked to PARP1 via an 'interacts with' relationship and subsequently linked to 'protein binding' via an 'enables' relationship. One of these entities is reported to interact with PARP1 at the PARP-A-helical domain and to deacetylate the K249 residue of PARP1. Which disease is associated with... | basal-like breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08519","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to PARP1 via an 'interacts with' relationship and subsequently linked to 'protein binding'... | |
medium_hidden_intermediate_08520 | Enterovirus A is reported to downregulate a specific gene that is involved in the positive regulation of the apoptotic process. Experimental data for this gene indicates a log2 fold change of -2.085 and an adjusted p-value of 0.0001357. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08520","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene that is involved in the positive regulation of the apoptotic proce... | |
medium_hidden_intermediate_08521 | Human immunodeficiency virus 1 upregulates a gene that participates in the transport of small molecules. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 1.324 and an adjusted p-value of 0.008928. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08521","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the transport of small molecules. Experimental data f... | |
medium_hidden_intermediate_08523 | Zika virus downregulates a specific gene, which in turn binds to PRPF8. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -3.10 and an adjusted p-value of 0.016. Which protein is encoded by this gene? | RNA helicase aquarius | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08523","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn binds to PRPF8. Experimental data for this gene in glioma stem cells... | |
medium_hidden_intermediate_08526 | Zika virus downregulates a specific gene that participates in developmental biology. Experimental data for this gene shows a log2 fold change of -1.523 and an adjusted p-value of 0.01658. Which disease is associated with this gene through genomic alterations? | gastric cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08526","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in developmental biology. Experimental data for this gene shows a... | |
medium_hidden_intermediate_08527 | Hepacivirus C is reported to downregulate a gene that enables DNA-binding transcription factor activity. In a specific study, this gene exhibited a log2 fold change of approximately -1.029 and an adjusted p-value of 5.462e-06. Which protein is encoded by this gene? | Homeobox protein TGIF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08527","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables DNA-binding transcription factor activity. In a specific study... | |
medium_hidden_intermediate_08528 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to MCM4. The gene in question exhibits a log2 fold change of -2.436 and an adjusted p-value of 0.01344. Which protein is encoded by this gene? | DNA replication complex GINS protein PSF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08528","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_08534 | SRSF1 interacts with a protein that enables protein binding. Evidence regarding this protein states: 'A screen for Hub1 interactors identified Snu66, a component of the U4/U6.U5 tri-snRNP splicing complex.' Which protein is encoded by the gene corresponding to this interacting partner? | Ubiquitin-like protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08534","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"SRSF1 interacts with a protein that enables protein binding. Evidence regarding this protein states: 'A screen for Hub1 inte... | |
medium_hidden_intermediate_08535 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to depressive disorder via a biomarker relationship. One of these genes was reported in a study (GSE151803) involving a pancreatic cell line, with a log2 fold change of approximately -1.77 and an adjusted... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08535","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to depre... | |
medium_hidden_intermediate_08536 | Zika virus downregulates a specific gene that participates in diseases of metabolism. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.017 and an adjusted p-value of 0.03684. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08536","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in diseases of metabolism. Experimental data for this gene in gli... | |
medium_hidden_intermediate_08537 | Hepacivirus C upregulates a gene that subsequently binds to PPL. Experimental data for one such gene reports a log2 fold change of approximately 1.017 and an adjusted p-value of 0.0002114. Which protein is encoded by this specific gene? | Kazrin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08537","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that subsequently binds to PPL. Experimental data for one such gene reports a log2 fold cha... | |
medium_hidden_intermediate_08538 | In a study of non-small cell lung adenocarcinoma cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated and involved in the defense response to fungus. This gene exhibits a log2 fold change of approximately 1.44 and an adjusted p-value of 3.615e-06. Which protein is en... | Protein S100-A12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08538","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Severe acute respiratory syndrome-related coronavirus, ... | |
medium_hidden_intermediate_08540 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to schizophrenia via a biomarker relationship. One of these genes is reported in a study (GSE125686) involving natural killer cells, with a log2 fold change of approximately -1.20 and an adjusted p-value of approxi... | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08540","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to schizophrenia v... | |
medium_hidden_intermediate_08541 | A gene is upregulated by Human gammaherpesvirus 8 and enables DNA-binding transcription activator activity, RNA polymerase II-specific. Evidence for this gene reports a log2 fold change of approximately 1.495 and an adjusted p-value of 0.03193. Which disease is connected to this gene through genomic alterations? | epilepsy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08541","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and enables DNA-binding transcription activator activity, RNA polymerase I... | |
medium_hidden_intermediate_08542 | Pegivirus C is reported to downregulate a gene that enables DNA-binding transcription factor activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibits a log2 fold change of approximately -1.16 and an adjusted p-value of 0.0057. Which gene interacts with this specific downregulated g... | BLZF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08542","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables DNA-binding transcription factor activity. In a study of periphe... | |
medium_hidden_intermediate_08543 | Human alphaherpesvirus 3 upregulates a gene that participates in the Immune System. Evidence for this gene reports a log2 fold change of 3.686 and an adjusted p-value of 2.169e-08. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08543","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that participates in the Immune System. Evidence for this gene reports a log2 fo... | |
medium_hidden_intermediate_08544 | Human immunodeficiency virus 1 upregulates a gene that is involved in protein stabilization. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately 1.79 and an adjusted p-value of approximately 0.00063. Which cellular component is this gene located in? | Shu complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08544","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in protein stabilization. Evidence for this gene in macro... | |
medium_hidden_intermediate_08546 | Zika virus downregulates a specific gene that is involved in anatomical structure morphogenesis. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.44 and an adjusted p-value of approximately 0.013. Which disease is associated with this gene? | sarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08546","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in anatomical structure morphogenesis. In a study of glioma stem c... | |
medium_hidden_intermediate_08548 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with ITCH. One of these genes was reported in a study using a pancreatic cell line (GSE151803) with a log2 fold change of approximately 1.245 and an adjusted p-value of 0.0402. What molecular function is enabled by this spec... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08548","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with ITCH. One of these gene... | |
medium_hidden_intermediate_08550 | Two genes are structurally linked to Cardiovirus A via downregulation and to ANLN via interaction. One of these genes has a reported log2 fold change of -1.432 and an adjusted p-value of 0.0303 in cervical adenocarcinoma cell lines. Which cellular component is the location of this specific gene? | cell surface | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08550","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via downregulation and to ANLN via interaction. One of these genes has a ... | |
medium_hidden_intermediate_08554 | Human immunodeficiency virus 1 downregulates a gene that participates in GPCR downstream signalling. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately -3.85 and an adjusted p-value of approximately 0.0039. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08554","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in GPCR downstream signalling. In a study of macrophag... | |
medium_hidden_intermediate_08555 | Human betaherpesvirus 5 upregulates a gene that is located in the cytoplasm. Evidence for this specific gene reports a log2 fold change of 1.053 and an adjusted p-value of 0.01421. Which disease is associated with this gene? | polyarticular arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08555","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is located in the cytoplasm. Evidence for this specific gene reports a log2 ... | |
medium_hidden_intermediate_08557 | Pegivirus C is reported to downregulate a gene that participates in the CDC42 GTPase cycle. Experimental data for one such gene in peripheral blood mononuclear cells (study GSE131504) shows a log2 fold change of approximately -1.32 and an adjusted p-value of approximately 0.0116. Which protein is encoded by this specif... | Dedicator of cytokinesis protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08557","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in the CDC42 GTPase cycle. Experimental data for one such g... | |
medium_hidden_intermediate_08558 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene that enables volume-sensitive anion channel activity. One such gene exhibited a log2 fold change of -1.143 and an adjusted p-value of 6.434e-05. Which protein is encoded by this sp... | Volume-regulated anion channel subunit LRRC8A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08558","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_08560 | Zika virus downregulates a gene that serves as a biomarker for hepatocellular carcinoma. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.143 and an adjusted p-value of 0.01584. Which protein is encoded by this gene? | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08560","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that serves as a biomarker for hepatocellular carcinoma. In a study of glioma stem cells (GS... | |
medium_hidden_intermediate_08561 | Zika virus upregulates a gene that participates in infectious disease processes. Experimental data for this gene reports a log2 fold change of 2.338 and an adjusted p-value of 0.003271. Which protein is encoded by this gene? | Transcription initiation factor TFIID subunit 7-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08561","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in infectious disease processes. Experimental data for this gene reports a l... | |
medium_hidden_intermediate_08562 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. Evidence for this gene reports a log2 fold change of -1.409 and an adjusted p-value of 0.02121. Which disease is associated with this gene through genomic a... | renal cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08562","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables RNA polymerase II cis-regulator... | |
medium_hidden_intermediate_08563 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to NCK1. This specific gene exhibits a log2 fold change of approximately 3.02 and an adjusted p-value of 1.15e-13. Which protein is encoded by this gene? | Docking protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08563","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to NCK1. This... | |
medium_hidden_intermediate_08564 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the cellular response to hypoxia. Evidence for this gene reports a log2 fold change of 1.183 and an adjusted p-value of 2.775e-06. Which protein is encoded by this gene? | Transducin beta-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08564","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the cellular response to hypoxi... | |
medium_hidden_intermediate_08565 | A gene serves as a marker for monocytes and is enriched in conventional dendritic cells. Evidence for this gene reports a mean expression of 11.97 TPM, a z-score of 1.84, and a fold enrichment of 4.43. Which disease is associated with this gene through genomic alterations? | polycystic ovary syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08565","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for monocytes and is enriched in conventional dendritic cells. Evidence for this gene reports a me... | |
medium_hidden_intermediate_08566 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that participate in the Cell Cycle. One such gene exhibited a log2 fold change of approximately 4.27 and an adjusted p-value of 3.86e-08. Which protein is encoded by this specific gene? | ATP-dependent DNA helicase PIF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08566","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_08567 | Measles morbillivirus upregulates a gene that is involved in the positive regulation of DNA-templated transcription. Evidence for this specific gene reports a log2 fold change of approximately 1.643 and an adjusted p-value of 0.0005268. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08567","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the positive regulation of DNA-templated transcription. Evidenc... | |
medium_hidden_intermediate_08568 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Developmental Lineages of the Mammary Gland. Evidence for this gene reports a log2 fold change of 2.403 and an adjusted p-value of 0.0003409. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08568","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Developmental Lineage... | |
medium_hidden_intermediate_08569 | Zaire ebolavirus infection leads to the upregulation of specific genes that participate in infectious disease processes. In a study of retinal pigment epithelium cells (GSE100839), one such upregulated gene exhibited a log2 fold change of 4.520 and an adjusted p-value of 6.07e-05. Which protein is encoded by this speci... | E3 ISG15--protein ligase HERC5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08569","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of specific genes that participate in infectious disease processes. In ... | |
medium_hidden_intermediate_08570 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in cell adhesion. One of these genes has a reported log2 fold change of 1.744 and an adjusted p-value of 0.01222. Which disease is associated with this specific gene as a biomarker? | Squamous cell carcinoma of the head and neck | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08570","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in cell adhesion. One of... | |
medium_hidden_intermediate_08571 | A gene is downregulated by Primate bocaparvovirus 1 and participates in the transport of small molecules. Experimental evidence for this gene reports a log2 fold change of -2.812 and an adjusted p-value of 0.01762. Which protein is encoded by this gene? | Aquaporin-9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08571","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in the transport of small molecules. Experimental evide... | |
medium_hidden_intermediate_08572 | Pegivirus C is reported to downregulate a gene that is involved in lipid droplet formation. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.598 and an adjusted p-value of 0.0002314. Which protein is encoded by this specific gene? | Phosphatidylserine decarboxylase proenzyme, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08572","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in lipid droplet formation. In a study of peripheral blood m... | |
medium_hidden_intermediate_08573 | A gene is downregulated by Human gammaherpesvirus 8 and participates in the Immune System. Experimental data for this gene in vascular endothelial cells (study GSE16354) reports a log2 fold change of -1.571 and an adjusted p-value of 0.003591. Which protein does this gene product bind to? | TNFRSF8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08573","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and participates in the Immune System. Experimental data for this gene i... | |
medium_hidden_intermediate_08574 | Vaccinia virus upregulates a gene that is involved in the innate immune response. Evidence for one such gene reports a log2 fold change of 2.782 and an adjusted p-value of 1.061e-08. Which disease is connected to that gene through genomic alterations? | Meniere disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08574","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that is involved in the innate immune response. Evidence for one such gene reports a log2 ... | |
medium_hidden_intermediate_08575 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus and enabling enzyme binding was found to have a log2 fold change of approximately -2.6 and an adjusted p-value of 0.034. Which disease is associated with this specific gene? | hyperplasia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08575","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus and enabling enzyme bind... | |
medium_hidden_intermediate_08576 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the late endosome membrane. Evidence for this gene reports a log2 fold change of 1.323 and an adjusted p-value of 0.01468. Which gene interacts with this upregulated gene? | UNC93B1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08576","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the late endosome membrane. Evid... | |
medium_hidden_intermediate_08577 | Zika virus infection leads to the upregulation of specific genes that are enriched in natural killer cells. One such gene exhibits a log2 fold change of approximately 1.27 and an adjusted p-value of 0.0075 in neural stem cells. Which protein is encoded by this gene? | Zinc finger protein 616 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08577","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the upregulation of specific genes that are enriched in natural killer cells. One such gene ex... | |
medium_hidden_intermediate_08578 | Glipizide interacts with a specific drug, which in turn interacts with activated charcoal. Clinical evidence indicates that for this intermediate drug, activated charcoal and cholestyramine significantly decrease its half-life due to enterohepatic circulation, a factor to consider in cases of acute toxicity. What disea... | rheumatoid arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08578","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Glipizide interacts with a specific drug, which in turn interacts with activated charcoal. Clinical evidence indicates that ... | |
medium_hidden_intermediate_08580 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to Transmission across Chemical Synapses via a 'participates in' relationship. One of these genes has an associated expression profile showing a log2 fold change of -1.778 and an adjusted p-... | potassium ion transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08580","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_08581 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables sodium channel regulator activity. Evidence for one such gene reports a log2 fold change of 1.359 and an adjusted p-value of 0.01267. Which protein is encoded by that gene? | Fibroblast growth factor 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08581","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables sodium channel regulator activity. Evi... | |
medium_hidden_intermediate_08582 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to diabetic kidney disease via a therapeutic relationship. One of these genes is associated with a study reporting a log2 fold change of 8.352 and an adjusted p-value of 0.01059. Which protein is encoded b... | Kallikrein-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08582","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to diabet... | |
medium_hidden_intermediate_08583 | Measles morbillivirus upregulates a gene that participates in extracellular matrix organization. Evidence for one such gene reports a log2 fold change of 1.097 and an adjusted p-value of 0.01715. Which disease is associated with genomic alterations in that specific gene? | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08583","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in extracellular matrix organization. Evidence for one such gene ... | |
medium_hidden_intermediate_08585 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in aerobic respiration and respiratory electron transport. This specific gene exhibited a log2 fold change of -1.492 and an adjusted p-value of 0.0002184. Which protein is encoded by this gene? | Cytochrome c oxidase assembly protein COX18, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08585","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in ... | |
medium_hidden_intermediate_08586 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the process 'TP53 Regulates Transcription of Cell Cycle Genes'. One of these genes was reported in a study (GSE153218) using SAEC cells, showing a log2 fold change of approximately 1.97 and an adjusted p-value of 0.035... | mammary neoplasms, animal | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08586","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the process 'TP53 Regu... | |
medium_hidden_intermediate_08587 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to RPS27A via a 'binds' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.234 and an adjusted p-value of 0.001483. Which protein is encod... | F-box only protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08587","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_08588 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with YWHAH. Evidence for one such gene reports a log2 fold change of -1.701 and an adjusted p-value of 0.0002845. Which protein is encoded by that gene? | FYVE, RhoGEF and PH domain-containing protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08588","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with YWHAH. Evidence for one such ... | |
medium_hidden_intermediate_08590 | EIF4E interacts with a protein that possesses a specific motif; point mutations in this motif abolish the interaction with eIF-4E. This protein is also known to enable protein binding. Which protein is encoded by the gene corresponding to this interacting partner? | Eukaryotic translation initiation factor 4E-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08590","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"EIF4E interacts with a protein that possesses a specific motif; point mutations in this motif abolish the interaction with e... | |
medium_hidden_intermediate_08591 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE155241), a specific gene is downregulated by the virus and localized to focal adhesions. This gene exhibits a log2 fold change of -2.675 and an adjusted p-value of 0.007533. Which biological process is this gene involved in... | focal adhesion assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08591","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE155241), a specific gene is... |
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