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medium_hidden_intermediate_08593 | In a study of cervical adenocarcinoma cells (GSE11238), a gene upregulated by Vaccinia virus and known to interact with SNRPB exhibits a log2 fold change of 1.585 and an adjusted p-value of 0.002384. Which cellular component is this gene located in? | kinetochore | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08593","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), a gene upregulated by Vaccinia virus and known to interact with SNRP... | |
medium_hidden_intermediate_08594 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that enable protein homodimerization activity. One such gene exhibited a log2 fold change of 2.008 and an adjusted p-value of 0.004107. Which protein is encoded by this specific gene? | Grainyhead-like protein 1 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08594","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that enable ... | |
medium_hidden_intermediate_08595 | Human betaherpesvirus 5 is reported to downregulate a gene that is enriched in intermediate monocytes. Evidence for one such gene indicates a log2 fold change of -1.718 and an adjusted p-value of 0.02089. Which protein is encoded by this gene? | DNA damage-regulated autophagy modulator protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08595","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is enriched in intermediate monocytes. Evidence for one such... | |
medium_hidden_intermediate_08596 | Zika virus downregulates a specific gene that participates in chromatin modifying enzymes. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.350 and an adjusted p-value of 0.0264. Which disease is associated with this gene? | Karayol-Borroto-Haghshenas neurodevelopmental syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08596","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in chromatin modifying enzymes. Experimental data for this gene i... | |
medium_hidden_intermediate_08597 | Human immunodeficiency virus 1 upregulates a gene that is associated with squamous cell carcinoma. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 3.25 and an adjusted p-value of approximately 0.0054. Which protein is encoded by this gene? | Tumor protein D52 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08597","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with squamous cell carcinoma. In a study of macrophages... | |
medium_hidden_intermediate_08602 | Zika virus downregulates a gene that participates in Class I MHC mediated antigen processing & presentation. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.532 and an adjusted p-value of 0.007123. Which protein is encoded by this gene? | Kelch-like protein 20 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08602","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Class I MHC mediated antigen processing & presentation. In a study of g... | |
medium_hidden_intermediate_08603 | Pegivirus C is reported to downregulate a gene that is involved in the negative regulation of DNA-templated transcription. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.145 and an adjusted p-value of 0.006552. Which protein is encoded by this specific gen... | LanC-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08603","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the negative regulation of DNA-templated transcription. I... | |
medium_hidden_intermediate_08604 | Pegivirus C is reported to downregulate a specific gene, the product of which binds to UTP15. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.572 and an adjusted p-value of 0.04993. Which protein is encoded by this gene? | U3 small nucleolar ribonucleoprotein protein IMP3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08604","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, the product of which binds to UTP15. In a study of peripheral blood... | |
medium_hidden_intermediate_08605 | Two genes are structurally linked to Vaccinia virus via an upregulation relationship and to POMK via an interaction relationship. One of these genes is reported in a study (GSE11238) with a log2 fold change of approximately 1.435 and an adjusted p-value of approximately 2.52e-06. Which cell type is this specific gene e... | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08605","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Vaccinia virus via an upregulation relationship and to POMK via an interaction relation... | |
medium_hidden_intermediate_08606 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of canonical NF-kappaB signal transduction. Experimental data for this gene, derived from peripheral blood mononuclear cells in study GSE131504, indicate a log2 fold change of -1.084 and an adjusted p-valu... | Ischemic stroke | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08606","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of canoni... | |
medium_hidden_intermediate_08607 | Zika virus downregulates a specific gene, which in turn interacts with STAU1. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.354 and an adjusted p-value of 0.0123. Which disease is associated with this gene? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08607","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with STAU1. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_08608 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which is located in the axon. This gene exhibited a log2 fold change of -1.191 and an adjusted p-value of 0.009869. Which protein is encoded by this gene? | Leucine-rich repeat transmembrane neuronal protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08608","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_08609 | In a study of Influenza A virus infection, a specific gene is upregulated and its product is enriched in non-classical monocytes. Evidence for this gene reports a log2 fold change of approximately 1.111 and an adjusted p-value of 0.0003429. Which protein is encoded by this gene? | RING finger protein 122 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08609","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated and its product is enriched in non-classical monoc... | |
medium_hidden_intermediate_08610 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a specific gene that participates in GPCR signaling. This gene exhibited a log2 fold change of approximately -1.118 and an adjusted p-value of 0.001044. Which protein is encoded by this gene? | Protein ADM2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08610","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_08611 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Chondroitin sulfate/dermatan sulfate metabolism. Evidence for this gene reports a log2 fold change of 1.091 and an adjusted p-value of 0.04445. Which protein is encoded by this gene? | Chondroitin sulfate proteoglycan 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08611","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Chondroitin sulfate/dermatan s... | |
medium_hidden_intermediate_08612 | Hepacivirus C is associated with the downregulation of a specific gene, which is in turn enriched in Gamma delta (γδ) T cells. Experimental data for this gene reports a log2 fold change of -1.489 and an adjusted p-value of 0.04212. Which protein is encoded by this gene? | Synaptotagmin-11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08612","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a specific gene, which is in turn enriched in Gamma delta (γδ) T cell... | |
medium_hidden_intermediate_08613 | Human betaherpesvirus 5 is reported to downregulate a specific gene, which is subsequently found to be enriched in natural killer cells. In a study of foreskin fibroblast cell lines (GSE111036), this gene exhibited a log2 fold change of approximately -1.434 and an adjusted p-value of 0.03629. What molecular function is... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08613","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene, which is subsequently found to be enriched in natural k... | |
medium_hidden_intermediate_08614 | Human immunodeficiency virus 1 downregulates a gene that is involved in protein import into the nucleus. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -2.05 and an adjusted p-value of approximately 0.0008. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08614","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in protein import into the nucleus. In a study of macro... | |
medium_hidden_intermediate_08617 | Human immunodeficiency virus 1 downregulates a gene that is involved in heterochromatin formation. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of -1.118 and an adjusted p-value of 0.006866. Which cellular component is this gene located in? | chromatin silencing complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08617","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in heterochromatin formation. Evidence for this gene in... | |
medium_hidden_intermediate_08618 | A gene serves as a marker for T cells and is enriched in plasmacytoid dendritic cells. Expression data for this gene indicates a mean expression of 280.25 TPM, a z-score of 1.52, and a fold enrichment of 6.81. Which disease is associated with this gene through genomic alterations? | pleurisy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08618","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for T cells and is enriched in plasmacytoid dendritic cells. Expression data for this gene indicat... | |
medium_hidden_intermediate_08619 | Pegivirus C downregulates a gene that subsequently binds to POLR2I. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -2.337 and an adjusted p-value of 0.004044. Which protein is encoded by this specific gene? | Luc7-like protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08619","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that subsequently binds to POLR2I. In a study of peripheral blood mononuclear cells (GSE131... | |
medium_hidden_intermediate_08622 | Hepacivirus C upregulates a gene that enables serine-type peptidase activity. In a study of hepatocytes (GSE132606), one such gene showed a log2 fold change of 2.535 and an adjusted p-value of 0.000227. Which disease is associated with this specific gene? | rheumatoid arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08622","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables serine-type peptidase activity. In a study of hepatocytes (GSE132606), one suc... | |
medium_hidden_intermediate_08624 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with VCP. One such gene exhibits a log2 fold change of 1.168 and an adjusted p-value of 0.0003727. Which protein is encoded by this specific gene? | Phosphopentomutase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08624","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with VC... | |
medium_hidden_intermediate_08625 | In a study of Measles morbillivirus infection, two genes are identified as being downregulated by the virus and enriched in basophils. One of these genes exhibits a log2 fold change of approximately -1.01 and an adjusted p-value of approximately 0.026. Which protein is encoded by this specific gene? | Synaptotagmin-like protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08625","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being downregulated by the virus and enriched in ... | |
medium_hidden_intermediate_08626 | Hepacivirus C upregulates multiple genes that subsequently interact with NFIA. One such gene exhibits a log2 fold change of 1.239 and an adjusted p-value of 9.771e-05 in peripheral blood mononuclear cells. Which protein is encoded by this specific gene? | Transcriptional regulator Kaiso | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08626","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates multiple genes that subsequently interact with NFIA. One such gene exhibits a log2 fold change of ... | |
medium_hidden_intermediate_08627 | GNG2 interacts with multiple genes that are enriched in neutrophils. One such gene exhibits a mean expression of 93.17 TPM, a z-score of 1.70, and a fold enrichment of 6.54 in immune cell RNA-seq data. What molecular function is enabled by this specific gene? | histamine receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08627","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GNG2 interacts with multiple genes that are enriched in neutrophils. One such gene exhibits a mean expression of 93.17 TPM, ... | |
medium_hidden_intermediate_08628 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of inflammatory response. Evidence for this gene reports a log2 fold change of 1.033 and an adjusted p-value of 0.00661. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08628","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of infl... | |
medium_hidden_intermediate_08631 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with goiter. One of these genes exhibits a log2 fold change of -1.079 and an adjusted p-value of 0.02393 in lung tissue. Which cellular component is the location of this specific gene? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08631","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with goiter. One of ... | |
medium_hidden_intermediate_08632 | Two genes are upregulated by Vaccinia virus and enriched in classical monocytes. One of these genes exhibits a log2 fold change of approximately 1.008 and an adjusted p-value of 8.013e-06 in cervical adenocarcinoma cell lines (study GSE11238). What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08632","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and enriched in classical monocytes. One of these genes exhibits a log2 fold cha... | |
medium_hidden_intermediate_08633 | Hepacivirus C upregulates multiple genes that are involved in small GTPase-mediated signal transduction. One such gene exhibits a log2 fold change of approximately 1.058 and an adjusted p-value of 4.761e-07 in liver cells. Which cellular component is this specific gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08633","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates multiple genes that are involved in small GTPase-mediated signal transduction. One such gene exhib... | |
medium_hidden_intermediate_08636 | Rift Valley fever phlebovirus upregulates a gene that is involved in the defense response to bacterium. In a study using SAEC cells (GSE102481), one such gene showed a log2 fold change of approximately 4.95 and an adjusted p-value of approximately 0.0052. Which protein is encoded by this gene? | Guanylate-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08636","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that is involved in the defense response to bacterium. In a study using SAE... | |
medium_hidden_intermediate_08637 | Zika virus downregulates a specific gene that participates in the MyD88 cascade initiated on the plasma membrane. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.985 and an adjusted p-value of 0.009902. Which disease is associated with this gene? | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08637","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the MyD88 cascade initiated on the plasma membrane. In a study... | |
medium_hidden_intermediate_08640 | In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are upregulated and their products bind to PDGFRB. One such gene exhibits a log2 fold change of approximately 1.75 and an adjusted p-value of approximately 0.0033. Which protein is encoded by this specific gene? | Growth factor receptor-bound protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08640","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are upregulated and their produ... | |
medium_hidden_intermediate_08641 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate certain genes whose products are located in the perinuclear region of the cytoplasm. One such gene exhibited a log2 fold change of approximately 1.436 and an adjusted p-value of 0.00602. Whi... | Zinc finger protein 35 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08641","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_08643 | Hepacivirus C downregulates a gene that enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. Evidence for this gene reports a log2 fold change of -1.754 and an adjusted p-value of 0.01857. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08643","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. Evide... | |
medium_hidden_intermediate_08646 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with benign neoplasm. Experimental evidence for this gene reports a log2 fold change of -2.564 and an adjusted p-value of 0.001326. Which protein is encoded by this gene? | Neuronal pentraxin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08646","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with benign neoplasm. Exp... | |
medium_hidden_intermediate_08647 | Two genes are upregulated by Vaccinia virus and participate in mitochondrial protein import. One of these genes shows a log2 fold change of 2.376 and an adjusted p-value of 1.228e-09 in cervical adenocarcinoma cells. Which cell type is enriched for the gene matching these expression statistics? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08647","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in mitochondrial protein import. One of these genes shows a log2... | |
medium_hidden_intermediate_08648 | Zika virus downregulates a specific gene, which in turn interacts with CAPZA2. Experimental data from glioma stem cells (study GSE114907) indicates that this intermediate gene has a log2 fold change of approximately -1.346 and an adjusted p-value of 0.04676. Which cellular component is this intermediate gene located in... | early endosome membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08648","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with CAPZA2. Experimental data from glioma stem cells (stu... | |
medium_hidden_intermediate_08650 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus and its product enables calmodulin binding. This gene exhibits a log2 fold change of 1.960 and an adjusted p-value of 0.0002557. Which protein is encoded by this gene? | Dynein regulatory complex protein 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08650","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus a... | |
medium_hidden_intermediate_08651 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and involved in mitochondrial calcium ion homeostasis. This gene exhibits a log2 fold change of approximately 1.105 and an adjusted p-value of 8.404e-06. Which protein is encoded by this gene? | Calcium uptake protein 2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08651","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_08652 | In a study of cardiomyocyte cell lines, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the response to retinoic acid. Evidence for this specific gene reports a log2 fold change of approximately 1.023 and an adjusted p-value of 0.01083. Which protein is encoded by this ... | Alkaline ceramidase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08652","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and i... | |
medium_hidden_intermediate_08653 | Zika virus downregulates a gene that is involved in protein import into the nucleus. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.608 and an adjusted p-value of 0.01961. Which protein is encoded by this specific gene? | Pituitary tumor-transforming gene 1 protein-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08653","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in protein import into the nucleus. In a study of glioma stem cells (GSE114... | |
medium_hidden_intermediate_08655 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with SRF. This gene exhibited a log2 fold change of -2.330 and an adjusted p-value of 0.000999. Which protein is encoded by this gene? | Four and a half LIM domains protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08655","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_08657 | Hepacivirus C downregulates multiple genes that are involved in the negative regulation of DNA-templated transcription. One such gene exhibits a log2 fold change of approximately -1.009 and an adjusted p-value of approximately 3.10e-05 in natural killer cells (study GSE125686). Which cellular component is this specific... | chromatin silencing complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08657","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates multiple genes that are involved in the negative regulation of DNA-templated transcription. One ... | |
medium_hidden_intermediate_08658 | Measles morbillivirus downregulates a gene that participates in the Generic Transcription Pathway. Experimental data for this gene shows a log2 fold change of -1.558 and an adjusted p-value of 1.389e-05. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08658","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that participates in the Generic Transcription Pathway. Experimental data for thi... | |
medium_hidden_intermediate_08659 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with RPL18. In a study of peripheral blood mononuclear cells (GSE131504), this intermediate gene exhibited a log2 fold change of -1.793 and an adjusted p-value of 0.001016. Which protein is encoded by this gene? | Deubiquitinase OTUD6B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08659","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with RPL18. In a study of peripheral blood ... | |
medium_hidden_intermediate_08660 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A was found to upregulate a specific gene that participates in the epigenetic regulation of gene expression. This gene exhibited a log2 fold change of approximately 1.027 and an adjusted p-value of 0.005866. Which protein does this upregulated gene interact ... | SUV39H1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08660","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A was found to upregulate a specific gene that participates in... | |
medium_hidden_intermediate_08661 | Pegivirus C is reported to downregulate a gene that is associated with cholangiocarcinoma. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibits a log2 fold change of approximately -1.27 and an adjusted p-value of 0.019. Which protein is encoded by this specific gene? | Histone-lysine N-methyltransferase SMYD3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08661","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is associated with cholangiocarcinoma. In a study of peripheral blood mo... | |
medium_hidden_intermediate_08662 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Fatty acid metabolism. One of these genes exhibits a log2 fold change of 1.787 and an adjusted p-value of 0.0001448 in lung tissue. Which biological process is this specific gene involved in? | fatty acid beta-oxidation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08662","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Fatty acid metabolism.... | |
medium_hidden_intermediate_08663 | Pegivirus C is reported to downregulate a gene that is involved in rRNA methylation. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.556 and an adjusted p-value of 0.02775. Which protein is encoded by this specific gene? | rRNA N(6)-adenosine-methyltransferase ZCCHC4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08663","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in rRNA methylation. In a study of peripheral blood mononucl... | |
medium_hidden_intermediate_08665 | Zika virus downregulates a specific gene, which in turn interacts with RPS2. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.092 and an adjusted p-value of 0.00848. Which cellular component is this gene located in? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08665","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with RPS2. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_08666 | Zika virus downregulates a specific gene, which in turn interacts with HNRNPA1. Experimental data from glioma stem cells (study GSE114907) indicates that this intermediate gene has a log2 fold change of -1.190 and an adjusted p-value of 0.02453. Which gene binds to this intermediate entity? | PTK6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08666","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with HNRNPA1. Experimental data from glioma stem cells (st... | |
medium_hidden_intermediate_08667 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in the translation of structural proteins. Experimental data for this gene indicates a log2 fold change of -2.378 and an adjusted p-value of 0.006992. In which cell type is this gene enriched? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08667","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in the translation of structural protein... | |
medium_hidden_intermediate_08669 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and its product is located in the axoneme. Transcriptomic data for this gene shows a log2 fold change of -1.149 and an adjusted p-value of 0.0004051. Which protein is encoded by this gene? | Microtubule-associated protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08669","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and its product is located in the axoneme. ... | |
medium_hidden_intermediate_08670 | Two genes are upregulated by Hepacivirus C and interact with RAB11A. One of these genes shows a log2 fold change of approximately 1.05 and an adjusted p-value of approximately 0.0057 in peripheral blood mononuclear cells from study GSE119117. Which disease is associated with this specific gene? | arthrogryposis multiplex congenita 4, neurogenic, with agenesis of the corpus callosum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08670","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Hepacivirus C and interact with RAB11A. One of these genes shows a log2 fold change of approxim... | |
medium_hidden_intermediate_08671 | Human betaherpesvirus 5 upregulates a gene that participates in the process 'TP53 Regulates Transcription of Death Receptors and Ligands'. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately 1.048 and an adjusted p-value of 0.001197. Which protein is encoded by ... | Tumor necrosis factor receptor superfamily member 10C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08671","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the process 'TP53 Regulates Transcription of Death Receptors... | |
medium_hidden_intermediate_08672 | In a study of sclera cells (GSE164073), a gene upregulated by Severe acute respiratory syndrome-related coronavirus and associated with diabetes mellitus as a biomarker showed a log2 fold change of 8.352 and an adjusted p-value of 0.01059. Which molecular function is enabled by this specific gene? | serine-type endopeptidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08672","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), a gene upregulated by Severe acute respiratory syndrome-related coronavirus and asso... | |
medium_hidden_intermediate_08673 | Enterovirus A infection leads to the upregulation of specific genes whose protein products are located in the endoplasmic reticulum membrane. In a study of rhabdomyosarcoma cells (GSE103308), one such gene exhibited a log2 fold change of approximately 1.056 and an adjusted p-value of 0.02896. Which protein is encoded b... | N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08673","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A infection leads to the upregulation of specific genes whose protein products are located in the endoplasmic re... | |
medium_hidden_intermediate_08675 | In a study of Influenza A virus infection, a specific gene is upregulated and participates in Class I MHC mediated antigen processing & presentation. Evidence for this gene reports a log2 fold change of approximately 1.093 and an adjusted p-value of 0.0009668. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08675","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated and participates in Class I MHC mediated antigen p... | |
medium_hidden_intermediate_08676 | Two distinct drugs are known to interact with both Cyclosporine and Brigatinib. One of these drugs has a documented significant interaction potential with maribavir in solid organ transplant recipients, which can lead to elevated levels of calcineurin inhibitors (such as cyclosporine and tacrolimus) and mTOR inhibitors... | cytomegalovirus infection | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08676","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are known to interact with both Cyclosporine and Brigatinib. One of these drugs has a documented signific... | |
medium_hidden_intermediate_08677 | Hepacivirus C is associated with the downregulation of a specific gene, which is in turn enriched in naive CD4+ T cells. Experimental data for this gene reports a log2 fold change of -1.405 and an adjusted p-value of 1.385e-06. Which protein is encoded by this gene? | Zinc finger protein 563 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08677","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a specific gene, which is in turn enriched in naive CD4+ T cells. Exp... | |
medium_hidden_intermediate_08678 | A protein interacts with DDB1 and enables beta-adrenergic receptor kinase activity. Experimental evidence indicates that this protein associates with the DDB1-CUL4 complex, with DDB1 acting as an adapter to link the protein to CUL4. Which gene encodes this protein? | G protein-coupled receptor kinase 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08678","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein interacts with DDB1 and enables beta-adrenergic receptor kinase activity. Experimental evidence indicates that thi... | |
medium_hidden_intermediate_08679 | Hepacivirus C downregulates a gene that is involved in protein stabilization. In a study of peripheral blood mononuclear cells (GSE119117), one such gene exhibited a log2 fold change of approximately -1.36 and an adjusted p-value of approximately 0.0014. Which protein is encoded by this specific gene? | Progestin and adipoQ receptor family member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08679","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that is involved in protein stabilization. In a study of peripheral blood mononuclear cel... | |
medium_hidden_intermediate_08680 | Influenza A virus upregulates a gene that interacts with DDIT3. One such gene exhibits a log2 fold change of 1.778 and an adjusted p-value of 7.485e-05 in a specific study. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08680","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus upregulates a gene that interacts with DDIT3. One such gene exhibits a log2 fold change of 1.778 and an ad... | |
medium_hidden_intermediate_08681 | Zika virus downregulates a specific gene that is located in the Golgi membrane. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.24 and an adjusted p-value of approximately 0.0305. Which disease is associated with this gene as a biomarker? | depressive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08681","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is located in the Golgi membrane. Experimental data for this gene in glioma st... | |
medium_hidden_intermediate_08683 | Pegivirus C downregulates a gene that participates in the CDC42 GTPase cycle. Evidence for this gene in peripheral blood mononuclear cells (study GSE131504) reports a log2 fold change of approximately -1.49 and an adjusted p-value of approximately 0.0116. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08683","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in the CDC42 GTPase cycle. Evidence for this gene in peripheral blood mon... | |
medium_hidden_intermediate_08687 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that enable identical protein binding. One such gene exhibits a log2 fold change of -1.407 and an adjusted p-value of 0.00665. Which protein is encoded by this specific gene? | Dehydrogenase/reductase SDR family member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08687","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that ... | |
medium_hidden_intermediate_08688 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are enriched in Gamma delta(γδ) T cells. One of these genes exhibits a log2 fold change of -1.381 and an adjusted p-value of 0.0006587 in a specific study. What molecular function is enabled by this specific gene? | 1-acylglycerophosphocholine O-acyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08688","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are enriched in Gamma delta(γδ) T c... | |
medium_hidden_intermediate_08691 | A gene is upregulated by Zika virus and enriched in neutrophils. Experimental data for this gene reports a log2 fold change of 2.376 and an adjusted p-value of 0.004761. Which disease is associated with this gene? | diabetes mellitus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08691","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Zika virus and enriched in neutrophils. Experimental data for this gene reports a log2 fold change ... | |
medium_hidden_intermediate_08694 | A gene is upregulated by Primate bocaparvovirus 1 and is enriched in non-classical monocytes. Evidence for this gene reports a log2 fold change of 1.825 and an adjusted p-value of 0.04092. Which gene interacts with the entity identified by these statistics? | AXIN1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08694","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is enriched in non-classical monocytes. Evidence for this gene reports... | |
medium_hidden_intermediate_08695 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Mitochondrial protein import. Experimental evidence for this gene reports a log2 fold change of -1.062 and an adjusted p-value of 0.0002271. Which protein is encoded by this gene? | Frataxin, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08695","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Mitochondrial protein i... | |
medium_hidden_intermediate_08696 | Pegivirus C is reported to downregulate a specific gene, the product of which interacts with PTEN. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of approximately -2.36 and an adjusted p-value of 0.00012. Which protein is encoded by this gene? | F-box only protein 22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08696","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, the product of which interacts with PTEN. In a study of peripheral ... | |
medium_hidden_intermediate_08697 | A gene is upregulated by Human gammaherpesvirus 8 and enriched in neutrophils. Evidence for this gene reports a log2 fold change of approximately 4.70 and an adjusted p-value of 0.04546. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08697","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and enriched in neutrophils. Evidence for this gene reports a log2 fold ch... | |
medium_hidden_intermediate_08698 | Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with obesity disorder. One of these genes was reported in a study (GSE164073) involving sclera cells, with a log2 fold change of approximately 1.747 and an adjusted p-value of 0.01246. Which disease is linked to this ... | desmoplastic small round cell tumor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08698","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with obesity disorder... | |
medium_hidden_intermediate_08699 | FGF2 is involved in a biological process that is a subtype of positive regulation of morphogenesis of an epithelium. One such process is defined as any process that activates or increases the frequency, rate, or extent of blood vessel branching. Which biological process is positively regulated by this specific entity? | branching involved in blood vessel morphogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08699","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"FGF2 is involved in a biological process that is a subtype of positive regulation of morphogenesis of an epithelium. One suc... | |
medium_hidden_intermediate_08700 | Hepacivirus C upregulates a gene that enables ATP binding. Evidence for one such gene reports a log2 fold change of 1.017 and an adjusted p-value of 3.562e-06. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08700","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables ATP binding. Evidence for one such gene reports a log2 fold change of 1.017 an... | |
medium_hidden_intermediate_08701 | Hepacivirus C upregulates a gene that participates in neutrophil degranulation. One such gene exhibits a log2 fold change of 4.747 and an adjusted p-value of 0.02119 in a specific study. Which protein is encoded by this gene? | Nicotinate phosphoribosyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08701","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in neutrophil degranulation. One such gene exhibits a log2 fold change of... | |
medium_hidden_intermediate_08702 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both interact with NCOR1. One of these genes exhibits a log2 fold change of -1.519 and an adjusted p-value of 1.567e-06 in a specific study. Which cellular component is the gene matching these statistical values located in? | transcription repressor complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08702","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both interact with NCOR1. One of th... | |
medium_hidden_intermediate_08703 | Severe acute respiratory syndrome-related coronavirus upregulates a gene involved in protein deubiquitination. Evidence for one such gene reports a log2 fold change of 1.383 and an adjusted p-value of 0.008914. Which cellular component is that gene located in? | Golgi apparatus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08703","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene involved in protein deubiquitination. Evidence for ... | |
medium_hidden_intermediate_08704 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is upregulated and participates in the metabolism of steroids. Evidence for this gene reports a log2 fold change of 1.692 and an adjusted p-value of 0.008382. Which protein is encoded by this gene? | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08704","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is upregulated and participates in the... | |
medium_hidden_intermediate_08705 | Human immunodeficiency virus 1 is reported to downregulate a gene that serves as a biomarker for hepatocellular carcinoma. In a specific study (GSE108897) involving macrophages, this gene exhibited a log2 fold change of approximately -1.212 and an adjusted p-value of 0.02244. Which protein is encoded by this gene? | Mitochondrial pyruvate carrier 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08705","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 is reported to downregulate a gene that serves as a biomarker for hepatocellular carcinoma. I... | |
medium_hidden_intermediate_08706 | Monocyte homeostasis is a subtype of a specific biological process, which is itself a subtype of homeostasis of number of cells. Evidence for this intermediate process states: 'The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an o... | myeloid cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08706","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Monocyte homeostasis is a subtype of a specific biological process, which is itself a subtype of homeostasis of number of ce... | |
medium_hidden_intermediate_08707 | Human betaherpesvirus 5 downregulates a gene that is located in the cytosol. Evidence from a study on foreskin fibroblast cell lines (GSE111036) reports that this gene has a log2 fold change of approximately -1.145 and an adjusted p-value of approximately 0.0426. Which disease is associated with this gene? | diabetes mellitus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08707","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that is located in the cytosol. Evidence from a study on foreskin fibroblast ce... | |
medium_hidden_intermediate_08709 | A gene is upregulated by Measles morbillivirus and participates in Developmental Biology. Evidence for this gene reports a log2 fold change of 1.827 and an adjusted p-value of 0.003535. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08709","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in Developmental Biology. Evidence for this gene reports a l... | |
medium_hidden_intermediate_08710 | A protein entity is connected to GRB2 via an interaction and to the Immune System via participation. Experimental evidence indicates that the adapter proteins Grb2 and Shc interact with distinct and specific regions of the cytoplasmic domain of this entity. Which protein is encoded by this entity? | B-cell receptor CD22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08710","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein entity is connected to GRB2 via an interaction and to the Immune System via participation. Experimental evidence i... | |
medium_hidden_intermediate_08713 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to ischemic stroke via an association relationship. One of these genes exhibits a log2 fold change of approximately -1.88 and an adjusted p-value of approximately 0.0085 in macrophages from study GSE108897. Which p... | S-methylmethionine--homocysteine S-methyltransferase BHMT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08713","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to ischemic stroke... | |
medium_hidden_intermediate_08714 | In a study of choroid plexus epithelium (GSE157852), a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the conjugation of benzoate with glycine. This specific gene exhibits a log2 fold change of approximately 1.52 and an adjusted p-value of 0.00072. Which protein is enco... | Glycine N-acyltransferase-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08714","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), a gene is upregulated by Severe acute respiratory syndrome-related coro... | |
medium_hidden_intermediate_08715 | Two genes are downregulated by Pegivirus C and interact with RAC1. One of these genes exhibits a log2 fold change of approximately -1.79 and an adjusted p-value of approximately 0.0032 in peripheral blood mononuclear cells. Which cellular component is the location of this specific gene? | synapse | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08715","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and interact with RAC1. One of these genes exhibits a log2 fold change of approxi... | |
medium_hidden_intermediate_08716 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene involved in sulfation. One such gene exhibits a log2 fold change of approximately 2.89 and an adjusted p-value of approximately 0.023. Which protein is encoded by this specific gene? | Sulfotransferase 1C4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08716","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene involved in sulfation. One such gen... | |
medium_hidden_intermediate_08718 | In a study of non-small cell lung adenocarcinoma cell lines, a specific gene is identified as being upregulated by Influenza A virus and serving as a biomarker for lung carcinoma. This gene exhibits a log2 fold change of approximately 2.855 and an adjusted p-value of 0.02704. Which protein is encoded by this gene? | G0/G1 switch protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08718","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines, a specific gene is identified as being upregulated by Influenza... | |
medium_hidden_intermediate_08721 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the Mitotic G1 phase and G1/S transition. One of these genes exhibits a log2 fold change of 1.437 and an adjusted p-value of 2.955e-05 in lung cells. Which cellular component is the gene associated with this specific e... | alpha DNA polymerase:primase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08721","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the Mitotic G1 phase a... | |
medium_hidden_intermediate_08722 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in Rho protein signal transduction. One such gene exhibits a log2 fold change of approximately 1.49 and an adjusted p-value of 0.000116. Which protein is encoded by this specific gene? | Epidermal growth factor receptor kinase substrate 8-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08722","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in Rho protein sig... | |
medium_hidden_intermediate_08723 | RAB4A interacts with a protein that participates in Membrane Trafficking. Evidence for one such interacting partner states: 'This domain mediates the direct interaction with the GTP-bound form of Rab4, a small GTPase that has been implicated in recycling from early endosomes to the cell surface.' Which protein is encod... | Rab GTPase-binding effector protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08723","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"RAB4A interacts with a protein that participates in Membrane Trafficking. Evidence for one such interacting partner states: ... | |
medium_hidden_intermediate_08725 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycosaminoglycan metabolism. Experimental data for this gene in lung tissue shows a log2 fold change of approximately -2.57 and an adjusted p-value of 0.00013. Which biological process is this gene involved in? | chondroitin sulfate proteoglycan biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08725","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycosaminoglycan metab... | |
medium_hidden_intermediate_08726 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with TRMT61B. Evidence for this gene reports a log2 fold change of 1.183 and an adjusted p-value of 0.03199. Which protein is encoded by this gene? | Mitochondrial assembly of ribosomal large subunit protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08726","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with TRMT61B. Evidence for this gene... | |
medium_hidden_intermediate_08728 | Bone neoplasms can be localized to synovial limb joints. One such joint is described as connecting the forelimb zeugopod and stylopod skeletons. Which anatomical structure is this joint a part of? | elbow | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08728","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Bone neoplasms can be localized to synovial limb joints. One such joint is described as connecting the forelimb zeugopod and... | |
medium_hidden_intermediate_08730 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene involved in the glycoprotein biosynthetic process. This gene exhibited a log2 fold change of -1.080 and an adjusted p-value of 0.005118. Which protein is encoded by this gene? | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08730","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene involved in the ... | |
medium_hidden_intermediate_08731 | APOB interacts with a protein that is involved in the ERAD pathway. Experimental evidence indicates that this protein, identified as a member of the heat shock protein 90 family, co-immunoprecipitates with apoB and is associated with the luminal pool. Which protein is encoded by the gene corresponding to this entity? | Endoplasmin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08731","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"APOB interacts with a protein that is involved in the ERAD pathway. Experimental evidence indicates that this protein, ident... | |
medium_hidden_intermediate_08732 | Cardiovirus A downregulates a gene that is involved in the negative regulation of DNA-templated transcription. Experimental data from a cervical adenocarcinoma cell line (study GSE122967) indicates that this specific gene has a log2 fold change of -1.344 and an adjusted p-value of 0.02308. Which protein does this gene ... | TP53 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08732","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that is involved in the negative regulation of DNA-templated transcription. Experimental ... | |
medium_hidden_intermediate_08733 | Measles morbillivirus upregulates a gene that participates in the process where E3 ubiquitin ligases ubiquitinate target proteins. Transcriptomic data for this gene in pleural mesothelioma cells (study GSE117668) shows a log2 fold change of approximately 1.85 and an adjusted p-value of approximately 0.0043. Which prote... | Histone H2B type 1-N | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08733","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the process where E3 ubiquitin ligases ubiquitinate target pro... |
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