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medium_hidden_intermediate_08734 | Ureteral neoplasms are localized to an anatomical conduit. Evidence describes this entity as a fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, it is joined by the ejaculatory ducts and serves as a passageway for semen during ejacu... | urinary bladder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08734","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Ureteral neoplasms are localized to an anatomical conduit. Evidence describes this entity as a fibromuscular tubular canal t... | |
medium_hidden_intermediate_08735 | Measles morbillivirus upregulates a gene that is involved in the negative regulation of translation. Evidence for one such gene reports a log2 fold change of 1.022 and an adjusted p-value of 0.002966. Which disease is associated with this gene as a biomarker? | lip and oral cavity carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08735","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the negative regulation of translation. Evidence for one such g... | |
medium_hidden_intermediate_08737 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with CDC42. Evidence for one such gene reports a log2 fold change of -2.100 and an adjusted p-value of 0.01842. Which protein is encoded by that gene? | Septin-11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08737","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with CDC42. Evidence for one such ... | |
medium_hidden_intermediate_08738 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with RAC1. One of these genes exhibits a log2 fold change of -1.428 and an adjusted p-value of 0.009021 in lung tissue. Which biological process is this specific gene involved in? | endocytic recycling | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08738","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with RAC1. One of these ge... | |
medium_hidden_intermediate_08739 | In a study of rhabdomyosarcoma cells, a gene is identified as being downregulated by Enterovirus A and is known to enable RNA binding. This specific gene exhibits a log2 fold change of approximately -1.27 and an adjusted p-value of approximately 0.0297. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08739","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells, a gene is identified as being downregulated by Enterovirus A and is known to enable RN... | |
medium_hidden_intermediate_08740 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of specific genes located in chromatin. One such gene exhibits a log2 fold change of approximately -1.443 and an adjusted p-value of 0.01337. Which gene interacts with the partner associated with this speci... | PRKAB2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08740","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of specifi... | |
medium_hidden_intermediate_08743 | Measles morbillivirus upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Experimental data for one such gene reports a log2 fold change of 1.037 and an adjusted p-value of 0.0009755. Which protein interacts with this specific gene product? | SQSTM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08743","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. ... | |
medium_hidden_intermediate_08744 | Enterovirus A upregulates a specific gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately 1.027 and an adjusted p-value of approximately 0.0059. Which cellular component is this gene located in... | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08744","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a specific gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for this ... | |
medium_hidden_intermediate_08745 | A gene is upregulated by Human immunodeficiency virus 1 and participates in Cellular responses to stimuli. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 2.68 and an adjusted p-value of approximately 0.031. Which disease is associated with this gene? | AIDS related complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08745","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and participates in Cellular responses to stimuli. Experimental data... | |
medium_hidden_intermediate_08746 | Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of RNA splicing. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.41 and an adjusted p-value of 0.00652. Which protein is encoded by this specific gene? | Heterogeneous nuclear ribonucleoprotein L-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08746","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of RNA splicing. In a study of pe... | |
medium_hidden_intermediate_08750 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene that enables DNA binding. This gene exhibited a log2 fold change of approximately -2.83 and an adjusted p-value of 0.0085. Which protein is encoded by this gene? | ETS domain-containing protein Elk-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08750","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene that enables DNA... | |
medium_hidden_intermediate_08751 | Pegivirus C is reported to downregulate a specific gene, the product of which binds to EP300. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -2.259 and an adjusted p-value of 0.0001533. Which protein is encoded by this gene? | Aryl hydrocarbon receptor nuclear translocator | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08751","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, the product of which binds to EP300. In a study of peripheral blood... | |
medium_hidden_intermediate_08752 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene located in the centriole was found to be upregulated. This gene exhibited a log2 fold change of approximately 2.186 and an adjusted p-value of 2.917e-11. Which protein is encoded by this gene? | Coiled-coil domain-containing protein 68 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08752","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene located in the centr... | |
medium_hidden_intermediate_08754 | Two genes are structurally linked to Human immunodeficiency virus 1 via an 'upregulates' relationship and to leukoplakia via an 'associated with' relationship. One of these genes is reported in study GSE108897 (macrophage data) with a log2 fold change of 1.360 and an adjusted p-value of 0.008201. Which gene is connecte... | NCOA1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08754","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via an 'upregulates' relationship and to leukoplakia via... | |
medium_hidden_intermediate_08755 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with ANLN. This gene exhibits a log2 fold change of -1.866 and an adjusted p-value of 0.04606. Which protein is encoded by this gene? | RRP15-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08755","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_08756 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with MRPL11. Evidence for one such gene reports a log2 fold change of 1.017 and an adjusted p-value of 0.004812. Which protein is encoded by that gene? | Probable ATP-dependent RNA helicase DDX28 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08756","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with MRPL11. Evidence for one such g... | |
medium_hidden_intermediate_08758 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables phosphatidylinositol-3,4,5-trisphosphate binding. Evidence for this gene reports a log2 fold change of -1.305 and an adjusted p-value of 0.03561. Which disease is associated with this gene? | acute lymphoblastic leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08758","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables phosphatidylinositol-3,4,5-tris... | |
medium_hidden_intermediate_08760 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of canonical NF-kappaB signal transduction. One of these genes exhibits a log2 fold change of -1.254 and an adjusted p-value of 0.008917 in a specific study. Which disease is associated with ... | aneuploidy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08760","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regula... | |
medium_hidden_intermediate_08763 | Zika virus downregulates a specific gene, the product of which binds to EIF4A2. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.173 and an adjusted p-value of 0.01343. Which protein is encoded by this gene? | CCR4-NOT transcription complex subunit 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08763","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, the product of which binds to EIF4A2. In a study of glioma stem cells (GSE114907),... | |
medium_hidden_intermediate_08764 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene that participates in cell-cell junction organization. This gene exhibits a log2 fold change of approximately -2.17 and an adjusted p-value of approximately 0.025. What molecular function is enabled by this gene? | DNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08764","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene that participates in cel... | |
medium_hidden_intermediate_08765 | Two genes are downregulated by Pegivirus C and both bind to POLR2L. One of these genes exhibits a log2 fold change of -1.004 and an adjusted p-value of 0.003548 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08765","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and both bind to POLR2L. One of these genes exhibits a log2 fold change of -1.004... | |
medium_hidden_intermediate_08766 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene product is found to be downregulated by the virus and localized to extracellular exosomes. Experimental data for this entity reports a log2 fold change of -1.334 and an adjusted p-value of 9.718e-08. Which protein is... | Intercellular adhesion molecule 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08766","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene product is found to ... | |
medium_hidden_intermediate_08767 | Severe acute respiratory syndrome-related coronavirus is linked to the negative regulation of stress fiber assembly via a gene that is downregulated by the virus and involved in this process. One such gene exhibits a log2 fold change of -1.874 and an adjusted p-value of 0.02741. Which protein is encoded by this gene? | Cingulin-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08767","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is linked to the negative regulation of stress fiber assembly via a ge... | |
medium_hidden_intermediate_08770 | Zika virus downregulates a specific gene that participates in RAB geranylgeranylation. Experimental data for this gene shows a log2 fold change of approximately -2.01 and an adjusted p-value of 0.03285. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08770","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in RAB geranylgeranylation. Experimental data for this gene shows... | |
medium_hidden_intermediate_08771 | Human betaherpesvirus 5 is reported to downregulate a gene that enables transcription coactivator activity. In a study involving foreskin fibroblast cell lines, one such gene exhibited a log2 fold change of approximately -1.005 and an adjusted p-value of 0.003201. Which protein is encoded by this specific gene? | TOX high mobility group box family member 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08771","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that enables transcription coactivator activity. In a study invol... | |
medium_hidden_intermediate_08772 | Two genes are structurally linked to Vaccinia virus via an upregulation relationship and to TMEM43 via an interaction relationship. One of these genes exhibits a log2 fold change of 2.850 and an adjusted p-value of 1.937e-11 in a specific study. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08772","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Vaccinia virus via an upregulation relationship and to TMEM43 via an interaction relati... | |
medium_hidden_intermediate_08773 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes involved in the RHO GTPase cycle. One such gene exhibits a log2 fold change of approximately -2.65 and an adjusted p-value of 0.01085. Which protein is encoded by this specific gene? | Rho GDP-dissociation inhibitor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08773","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes invol... | |
medium_hidden_intermediate_08774 | Zika virus downregulates a gene that is located in the BLOC-1 complex. Experimental data from glioma stem cells (study GSE114907) reports a log2 fold change of -1.608 and an adjusted p-value of 0.04634 for this gene. Which protein is encoded by this gene? | Biogenesis of lysosome-related organelles complex 1 subunit 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08774","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the BLOC-1 complex. Experimental data from glioma stem cells (study GSE11... | |
medium_hidden_intermediate_08775 | Two distinct drugs serve as intermediates in a two-step interaction pathway connecting Interferon beta-1b to Fludarabine. One of these intermediates is referenced in a study reporting on the combined use of Fludarabine and conventional antiretroviral therapy (specifically AZT and DDI) in a murine model of AIDS (LP-BM5 ... | HIV infectious disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08775","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs serve as intermediates in a two-step interaction pathway connecting Interferon beta-1b to Fludarabine. On... | |
medium_hidden_intermediate_08776 | Two genes are identified as markers for fetal germ cells involved in oogenesis and are also implicated in RNA splicing. One of these genes is described by the following evidence: 'The homology between Nova and hnRNP K suggests that Nova regulates RNA splicing or metabolism in a specific subset of developing neurons.' W... | gastritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08776","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers for fetal germ cells involved in oogenesis and are also implicated in RNA splicing. One ... | |
medium_hidden_intermediate_08777 | Human betaherpesvirus 5 is reported to downregulate a gene that subsequently interacts with YWHAB. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibits a log2 fold change of approximately -2.04 and an adjusted p-value of 0.041. Which protein is encoded by this specific gene? | R3H domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08777","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that subsequently interacts with YWHAB. In a study of foreskin fi... | |
medium_hidden_intermediate_08778 | A gene is upregulated by Vaccinia virus and participates in Signaling by Rho GTPases. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 4.549 and an adjusted p-value of 1.191e-11. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08778","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and participates in Signaling by Rho GTPases. Experimental data for this gene in a c... | |
medium_hidden_intermediate_08779 | Vaccinia virus downregulates a gene that is enriched in plasmacytoid dendritic cells. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibits a log2 fold change of -1.315 and an adjusted p-value of 7.132e-06. Which protein is encoded by this gene? | Dual specificity phosphatase 28 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08779","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that is enriched in plasmacytoid dendritic cells. In a study of cervical adenocarcinoma ... | |
medium_hidden_intermediate_08780 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in chromatin. Experimental data for this gene reports a log2 fold change of approximately 1.408 and an adjusted p-value of 0.007199. Which disease is associated with this gene through genomic alterations? | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08780","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in chromatin. Experimental dat... | |
medium_hidden_intermediate_08782 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in the resolution of AP sites via the multiple-nucleotide patch replacement pathway. Evidence for this specific gene reports a log2 fold change of 1.501 and an adjusted p-value of 0.001079. Which protei... | Poly(ADP-ribose) glycohydrolase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08782","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in the... | |
medium_hidden_intermediate_08783 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to melanoma as biomarkers. One of these genes was reported in a study (GSE153218) using SAEC cells, showing a log2 fold change of approximately 1.50 and an adjusted p-value of 0.0197. Which protein is encoded by this spec... | Homeobox protein Hox-A9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08783","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to melanoma as biomarkers... | |
medium_hidden_intermediate_08784 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in disease. This specific gene exhibits a log2 fold change of 1.172 and an adjusted p-value of 0.02465. Which protein is encoded by this gene? | Prolyl 4-hydroxylase subunit alpha-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08784","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in disease. ... | |
medium_hidden_intermediate_08785 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene, which in turn encodes a protein that binds to COX19. The expression data for this gene shows a log2 fold change of approximately -1.494 and an adjusted p-value of 0.03067. Which protein is en... | Coenzyme Q-binding protein COQ10 homolog B, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08785","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_08786 | Human betaherpesvirus 5 is reported to downregulate a specific gene that enables identical protein binding. In a study using foreskin fibroblast cell lines, this gene exhibited a log2 fold change of -1.301 and an adjusted p-value of 0.0296. Which gene interacts with the entity connected to this downregulated gene? | UBC | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08786","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene that enables identical protein binding. In a study using... | |
medium_hidden_intermediate_08787 | Zika virus upregulates a gene that participates in the Innate Immune System. In a study of neural stem cells (GSE129180), one such gene showed a log2 fold change of 3.231 and an adjusted p-value of 0.009422. Which protein is encoded by this gene? | Complement factor B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08787","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in the Innate Immune System. In a study of neural stem cells (GSE129180), on... | |
medium_hidden_intermediate_08788 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and enabling ATPase binding. One of these genes exhibits a log2 fold change of 1.877 and an adjusted p-value of 0.002027. Which gene interacts with the gene exhibiting these specific statistical values? | FBXL20 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08788","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and enabling ATPas... | |
medium_hidden_intermediate_08789 | Human betaherpesvirus 5 is reported to downregulate a gene whose protein product is located in cell-cell junctions. In a study of foreskin fibroblast cell lines, one such gene exhibited a log2 fold change of -2.884 and an adjusted p-value of 9.057e-06. Which protein is encoded by this specific gene? | Teneurin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08789","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene whose protein product is located in cell-cell junctions. In a stu... | |
medium_hidden_intermediate_08790 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that subsequently interact with RPA1. One such gene exhibited a log2 fold change of 1.422 and an adjusted p-value of 2.58e-05. What molecular function is enabled by this specific gene? | ubiquitin protein ligase binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08790","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_08791 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables NAD+ poly-ADP-ribosyltransferase activity. Transcriptomic data for this gene shows a log2 fold change of approximately 1.25 and an adjusted p-value of approximately 0.00031. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08791","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables NAD+ poly-ADP-ribosyltransferase ... | |
medium_hidden_intermediate_08792 | Human immunodeficiency virus 1 downregulates a gene that participates in Signaling by Rho GTPases. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -5.81 and an adjusted p-value of 0.0104. Which cellular component is this gene located in? | cytoplasmic vesicle | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08792","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in Signaling by Rho GTPases. In a study of macrophages... | |
medium_hidden_intermediate_08793 | In a study of cardiomyocyte cell lines infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated and enables double-stranded DNA binding. This gene exhibits a log2 fold change of approximately 1.999 and an adjusted p-value of 0.007867. Which cellular component is this gene loca... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08793","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines infected with Severe acute respiratory syndrome-related coronavirus, a specific gene ... | |
medium_hidden_intermediate_08794 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the switching of origins to a post-replicative state. Experimental data for this gene shows a log2 fold change of 1.300 and an adjusted p-value of 0.03323. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08794","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the switching of origins ... | |
medium_hidden_intermediate_08795 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in chromatin. Evidence for this gene reports a log2 fold change of -1.119 and an adjusted p-value of 0.03106. Which gene interacts with this downregulated gene? | SS18L2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08795","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in chromatin. Evidence for this g... | |
medium_hidden_intermediate_08797 | A gene serves as a marker for neuroendocrine cells and is enriched in eosinophils. Evidence for one such gene reports a mean expression of 171.85 TPM, a z-score of 2.06, and a fold enrichment of 4.73. Which disease is associated with that specific gene? | myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08797","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for neuroendocrine cells and is enriched in eosinophils. Evidence for one such gene reports a mean... | |
medium_hidden_intermediate_08799 | Measles morbillivirus upregulates a gene that interacts with SFXN1. Evidence for one such gene reports a log2 fold change of 4.480 and an adjusted p-value of 0.04104. Which molecular function is enabled by that gene? | ATP:phosphate antiporter activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08799","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with SFXN1. Evidence for one such gene reports a log2 fold change of... | |
medium_hidden_intermediate_08800 | Human immunodeficiency virus 1 upregulates a specific gene, which in turn interacts with RHOB. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of 1.608 and an adjusted p-value of 0.005039. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08800","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a specific gene, which in turn interacts with RHOB. Experimental data for this ge... | |
medium_hidden_intermediate_08801 | Hepacivirus C upregulates a gene that participates in cellular responses to stress. Evidence for one such gene reports a log2 fold change of 2.856 and an adjusted p-value of 0.002835. Which protein is encoded by that gene? | Histone H2A.J | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08801","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in cellular responses to stress. Evidence for one such gene reports a log... | |
medium_hidden_intermediate_08802 | Zika virus downregulates a specific gene, which in turn enables actin binding. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of -1.797 and an adjusted p-value of 0.01255. Which protein is encoded by this gene? | Coronin-2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08802","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn enables actin binding. Experimental data from glioma stem cells (stu... | |
medium_hidden_intermediate_08803 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn interacts with EFTUD2. The upregulation of this gene is characterized by a log2 fold change of 1.091 and an adjusted p-value of 0.0005311. Which protein is en... | Zinc finger HIT domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08803","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upre... | |
medium_hidden_intermediate_08805 | Two genes are downregulated by Cardiovirus A and participate in Intra-Golgi and retrograde Golgi-to-ER traffic. One of these genes exhibits a log2 fold change of approximately -1.27 and an adjusted p-value of 0.0174 in cervical adenocarcinoma cells. Which biological process is this specific gene involved in? | negative regulation of apoptotic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08805","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Cardiovirus A and participate in Intra-Golgi and retrograde Golgi-to-ER traffic. One of these... | |
medium_hidden_intermediate_08808 | Human immunodeficiency virus 1 downregulates a gene that is located in the trans-Golgi network membrane. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of -2.798 and an adjusted p-value of 0.001842. Which protein is encoded by this gene? | Secretory carrier-associated membrane protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08808","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the trans-Golgi network membrane. Evidence for this g... | |
medium_hidden_intermediate_08809 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes involved in post-translational protein modification. One such gene exhibits a log2 fold change of -2.848 and an adjusted p-value of 5.986e-06. Which protein is encoded by this specific gene? | Insulin-like growth factor-binding protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08809","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes invol... | |
medium_hidden_intermediate_08813 | Pegivirus C downregulates a specific gene, which in turn interacts with RPA3. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) reports a log2 fold change of approximately -1.45 and an adjusted p-value of approximately 0.037. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08813","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, which in turn interacts with RPA3. Experimental data for this gene in peripheral ... | |
medium_hidden_intermediate_08814 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable protein serine/threonine kinase activity. One of these genes exhibits a log2 fold change of approximately 1.276 and an adjusted p-value of 0.01504 in lung tissue. Which cellular component is the location of this specific ... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08814","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable protein serine/threonine ... | |
medium_hidden_intermediate_08816 | Two genes are downregulated by Human immunodeficiency virus 1 and are associated with squamous cell carcinoma. One of these genes exhibits a log2 fold change of -1.860 and an adjusted p-value of 0.0231 in macrophages (study GSE108897). What molecular function is enabled by this specific gene? | prostaglandin E receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08816","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and are associated with squamous cell carcinoma. One of these ... | |
medium_hidden_intermediate_08817 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Nervous system development. Experimental data for this gene reports a log2 fold change of 1.043 and an adjusted p-value of 0.02528. Which protein is encoded by this gene? | LIM domain kinase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08817","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Nervous system developmen... | |
medium_hidden_intermediate_08818 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and interacts with SLC7A1. This specific gene exhibits a log2 fold change of 5.363 and an adjusted p-value of 0.0005247. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08818","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and interacts with SLC7A1. Th... | |
medium_hidden_intermediate_08819 | Zika virus infection has been shown to downregulate certain genes, which are subsequently associated with adenoviridae infectious disease. One such gene exhibits a log2 fold change of approximately -1.060 and an adjusted p-value of 0.0353 in glioma stem cells. Which protein is encoded by this specific gene? | Transmembrane reductase CYB561D2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08819","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection has been shown to downregulate certain genes, which are subsequently associated with adenoviridae infec... | |
medium_hidden_intermediate_08820 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with retinitis pigmentosa. One of these genes was reported in a study (GSE155241) involving lung cells, with a log2 fold change of approximately 1.067 and an adjusted p-value of 0.02934. Which disease is linked to this... | bipolar disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08820","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with retinitis pigment... | |
medium_hidden_intermediate_08822 | Measles morbillivirus upregulates a gene that participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3. Evidence for this gene reports a log2 fold change of 1.025 and an adjusted p-value of 0.01133. Which protein is encoded by this gene? | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08822","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3. Evidence f... | |
medium_hidden_intermediate_08823 | Hepacivirus C is reported to downregulate a gene that is involved in the positive regulation of transcription by RNA polymerase II. Experimental evidence for this specific gene shows a log2 fold change of -1.282 and an adjusted p-value of 9.787e-05. Which disease is associated with this gene? | amyloidosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08823","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is involved in the positive regulation of transcription by RNA polymer... | |
medium_hidden_intermediate_08825 | Measles morbillivirus upregulates a gene that participates in the Adaptive Immune System. Evidence for one such gene reports a log2 fold change of 1.278 and an adjusted p-value of 0.01732. Which protein is encoded by that gene? | Gamma-interferon-inducible lysosomal thiol reductase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08825","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the Adaptive Immune System. Evidence for one such gene reports... | |
medium_hidden_intermediate_08827 | In a study of Measles morbillivirus infection, a specific gene is upregulated and has been associated with lupus vulgaris. Transcriptomic data for this gene reports a log2 fold change of approximately 1.145 and an adjusted p-value of 0.02839. Which protein is encoded by this gene? | DNA topoisomerase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08827","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated and has been associated with lupus vulgaris. T... | |
medium_hidden_intermediate_08828 | A gene is upregulated by Primate bocaparvovirus 1 and participates in Signal Transduction. Experimental evidence for this gene reports a log2 fold change of 1.415 and an adjusted p-value of 0.03451. Which protein is encoded by this gene? | Calcium-binding protein 39 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08828","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in Signal Transduction. Experimental evidence for this ge... | |
medium_hidden_intermediate_08831 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables GTPase activity. Transcriptomic data for this gene in choroid plexus epithelium (study GSE157852) reports a log2 fold change of approximately 1.376 and an adjusted p-value of 0.0003347. Which disease is associated with this gene? | noonan syndrome 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08831","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables GTPase activity. Transcriptomic d... | |
medium_hidden_intermediate_08832 | Zika virus downregulates a gene that is involved in the mitotic cell cycle. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.624 and an adjusted p-value of 0.01128. Which protein is encoded by this gene? | Nuclear exosome regulator NRDE2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08832","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the mitotic cell cycle. In a study of glioma stem cells (GSE114907), one... | |
medium_hidden_intermediate_08834 | In a study of cervical adenocarcinoma cells (GSE122967), Cardiovirus A infection leads to the downregulation of specific genes located in the Golgi membrane. One such gene exhibits a log2 fold change of approximately -1.63 and an adjusted p-value of 0.0162. Which protein is encoded by this specific gene? | LysM and putative peptidoglycan-binding domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08834","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE122967), Cardiovirus A infection leads to the downregulation of specific gen... | |
medium_hidden_intermediate_08836 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection leads to the downregulation of certain genes that are enriched in plasmacytoid dendritic cells. One such gene exhibits a log2 fold change of approximately -1.175 and an adjusted p-value of 2.246e-07. Which protein is en... | Parathymosin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08836","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection leads to the downregula... | |
medium_hidden_intermediate_08837 | Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to glioma via an 'associated with' relationship. One of these genes has a reported log2 fold change of -1.130 and an adjusted p-value of 0.03164 in a specific study. Which cellular component is the location of this specific gene? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08837","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to glioma via an 'associated with'... | |
medium_hidden_intermediate_08838 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes whose products are located in the endosome membrane. One such gene exhibited a log2 fold change of approximately 1.56 and an adjusted p-value of 0.002. Which protein is encoded by this specific gene? | Ras-related protein Rab-15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08838","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes whose produc... | |
medium_hidden_intermediate_08840 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes, which in turn interact with the protein RPS6. One such gene exhibits a log2 fold change of 1.123 and an adjusted p-value of 0.01385. Which protein is encoded by this specific gene? | ATP-dependent RNA helicase DDX55 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08840","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes, which ... | |
medium_hidden_intermediate_08842 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Protein localization. Experimental data for this gene reports a log2 fold change of 1.061 and an adjusted p-value of 0.03045. Which biological process is this gene involved in? | L-lysine catabolic process to acetyl-CoA via L-pipecolate | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08842","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Protein localization. Exp... | |
medium_hidden_intermediate_08843 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in the process 'Amino acids regulate mTORC1'. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of -1.634 and an adjusted p-value of 0.002622. Which cell type is this g... | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08843","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in the process 'Amino acids regulate mTO... | |
medium_hidden_intermediate_08844 | Enterovirus A is known to upregulate certain genes that are subsequently associated with carcinoma. One such gene exhibits a log2 fold change of approximately 2.156 and an adjusted p-value of 0.0127 in rhabdomyosarcoma cells. Which disease is linked to this specific gene via a biomarker relationship? | aplastic anemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08844","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is known to upregulate certain genes that are subsequently associated with carcinoma. One such gene exhibits a... | |
medium_hidden_intermediate_08845 | A gene serves as a marker for mitotic arrest phase fetal germ cells and is localized to the centriole. Evidence indicates that this gene product is localized to centrosomes during early G1 phase, where it associates exclusively with the mother centriole, and subsequently distributes equally to both mother and daughter ... | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08845","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for mitotic arrest phase fetal germ cells and is localized to the centriole. Evidence indicates th... | |
medium_hidden_intermediate_08846 | Zika virus downregulates a specific gene, which in turn interacts with SLX4. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.27 and an adjusted p-value of 0.0098. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08846","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with SLX4. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_08849 | A gene serves as a marker for Paneth cells and is enriched in intermediate monocytes. Evidence for this gene includes a mean expression of 11103.62 TPM, a z-score of 1.53, and a fold enrichment of 6.69. Which disease is associated with this gene? | diabetes mellitus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08849","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Paneth cells and is enriched in intermediate monocytes. Evidence for this gene includes a mean... | |
medium_hidden_intermediate_08851 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and binding to KIT. This specific gene exhibits a log2 fold change of -1.248 and an adjusted p-value of 0.01148. Which protein is encoded by this gene? | Tyrosine-protein kinase Fer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08851","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and... | |
medium_hidden_intermediate_08852 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which in turn interacts with STK4. This gene exhibits a log2 fold change of approximately 1.464 and an adjusted p-value of 0.002931. What protein is encoded by this gene? | ATPase family AAA domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08852","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_08854 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene, which subsequently interacts with YWHAE. This gene exhibits a log2 fold change of approximately -1.125 and an adjusted p-value of 0.002122. Which biological process is this gene involved... | macrophage activation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08854","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_08855 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to the 'Cell Cycle, Mitotic' process via a 'participates in' relationship. One of these genes is associated with experimental evidence showing a log2 fold change of 1.015 and an adjusted p-va... | CTDNEP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08855","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_08856 | Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to SNCA via an interaction relationship. One of these genes exhibits a log2 fold change of approximately 1.44 and an adjusted p-value of 0.004738 in a specific study. Which cell type is enriched for this specific ge... | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08856","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to SNCA via an inte... | |
medium_hidden_intermediate_08857 | Pegivirus C downregulates a gene that participates in phospholipid metabolism. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.197 and an adjusted p-value of 0.0266. Which cellular component is this gene located in? | lysosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08857","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in phospholipid metabolism. In a study of peripheral blood mononuclear ce... | |
medium_hidden_intermediate_08859 | Measles morbillivirus upregulates a gene that participates in the RHO GTPase cycle. Evidence for this specific gene reports a log2 fold change of 1.387 and an adjusted p-value of 0.04715. Which protein is encoded by this gene? | Rho-related GTP-binding protein RhoJ | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08859","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the RHO GTPase cycle. Evidence for this specific gene reports ... | |
medium_hidden_intermediate_08863 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in O-linked glycosylation. One of these genes was reported in a study (GSE164073) on sclera cells with a log2 fold change of 3.374 and an adjusted p-value of 0.03203. Which disease is associated with this specific gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08863","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in O-linked glycosylation... | |
medium_hidden_intermediate_08864 | Vaccinia virus upregulates a gene that serves as a biomarker for colorectal carcinoma. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibited a log2 fold change of 1.512 and an adjusted p-value of 6.726e-06. Which protein is encoded by this specific gene? | Protein canopy homolog 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08864","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that serves as a biomarker for colorectal carcinoma. In a study of cervical adenocarcinoma... | |
medium_hidden_intermediate_08865 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to cervical carcinoma as biomarkers. One of these genes exhibits a log2 fold change of 1.161 and an adjusted p-value of 0.007923 in a specific study. Which protein is encoded by this gene? | Zinc finger protein 268 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08865","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to cervical carcinoma as ... | |
medium_hidden_intermediate_08867 | Human immunodeficiency virus 1 upregulates a gene that participates in peptide hormone metabolism. Evidence for one such gene reports a log2 fold change of 1.160 and an adjusted p-value of 0.01403. Which protein is encoded by that gene? | Neuroendocrine convertase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08867","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in peptide hormone metabolism. Evidence for one such gen... | |
medium_hidden_intermediate_08868 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Interferon Signaling. Evidence for this gene reports a log2 fold change of 1.739 and an adjusted p-value of 0.04532. Which gene interacts with this upregulated gene? | DAPK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08868","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Interferon Signaling. Evidence... | |
medium_hidden_intermediate_08869 | Zaire ebolavirus upregulates a gene that is involved in the defense response to virus. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of approximately 2.98 and an adjusted p-value of 0.0087. Which protein is encoded by this specific gene? | Phorbol-12-myristate-13-acetate-induced protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08869","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is involved in the defense response to virus. In a study of retinal pigment epithel... | |
medium_hidden_intermediate_08872 | In a study of hepatocytes (GSE135619), Orthohepevirus A infection was found to upregulate a specific gene that enables protein binding. This gene exhibited a log2 fold change of approximately 1.091 and an adjusted p-value of 0.006356. What is the name of the protein encoded by this gene? | LON peptidase N-terminal domain and RING finger protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08872","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of hepatocytes (GSE135619), Orthohepevirus A infection was found to upregulate a specific gene that enables prote... | |
medium_hidden_intermediate_08874 | PRKN is known to interact with a protein that is also located in the extracellular exosome. Evidence indicates that parkin interacts with this protein and promotes its ubiquitination. Which disease is associated with this specific interacting protein as a biomarker? | endogenous depression | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08874","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PRKN is known to interact with a protein that is also located in the extracellular exosome. Evidence indicates that parkin i... | |
medium_hidden_intermediate_08877 | Pegivirus C is reported to downregulate a gene that participates in calmodulin-induced events. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.616 and an adjusted p-value of 0.03046. Which protein is encoded by this specific gene? | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08877","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in calmodulin-induced events. In a study of peripheral bloo... | |
medium_hidden_intermediate_08878 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to YWHAE via an 'interacts with' relationship. One of these genes is reported in a study with a log2 fold change of approximately -1.158 and an adjusted p-value of 0.01538. Which cell type i... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08878","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_08880 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and its product interacts with CUL3. This gene exhibits a log2 fold change of approximately 1.267 and an adjusted p-value of 0.0002555. Which protein is encoded by this gene? | BTB/POZ domain-containing protein KCTD11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08880","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... |
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