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medium_hidden_intermediate_08882 | Zika virus downregulates multiple genes that participate in Cyclin A:Cdk2-associated events at S phase entry. One such gene exhibits a log2 fold change of approximately -1.81 and an adjusted p-value of approximately 0.0099 in glioma stem cells. Which protein is encoded by this specific gene? | M-phase inducer phosphatase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08882","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes that participate in Cyclin A:Cdk2-associated events at S phase entry. One such gene ... | |
medium_hidden_intermediate_08884 | Rhinovirus A infection is linked to aneuploidy via the upregulation of a specific gene. In a study of bronchial epithelial cells, this gene showed a log2 fold change of 1.301 and an adjusted p-value of 0.02802. Which protein is encoded by this gene? | Prostaglandin F2-alpha receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08884","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is linked to aneuploidy via the upregulation of a specific gene. In a study of bronchial epithelial c... | |
medium_hidden_intermediate_08885 | Human betaherpesvirus 5 downregulates a gene that participates in sphingolipid metabolism. Evidence for one such gene reports a log2 fold change of -1.381 and an adjusted p-value of 0.02259. Which disease is associated with that gene? | lung adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08885","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that participates in sphingolipid metabolism. Evidence for one such gene report... | |
medium_hidden_intermediate_08887 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in calcium ion transport. Evidence for this gene reports a log2 fold change of 1.044 and an adjusted p-value of 0.03189. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08887","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in calcium ion transport. Evi... | |
medium_hidden_intermediate_08888 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to SOX2 via an interaction relationship. One of these genes is reported in a study (GSE108897) on macrophages with a log2 fold change of -1.241 and an adjusted p-value of 0.02857. Which disease is associated with t... | bone osteosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08888","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to SOX2 via an int... | |
medium_hidden_intermediate_08889 | Zika virus downregulates a specific gene that participates in Viral Infection Pathways. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of approximately -1.094 and an adjusted p-value of 0.04345. Which protein is encoded by this gene? | Prolyl 4-hydroxylase subunit alpha-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08889","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in Viral Infection Pathways. Experimental data from glioma stem c... | |
medium_hidden_intermediate_08890 | Zaire ebolavirus downregulates multiple genes that are located in the plasma membrane. One such gene exhibits a log2 fold change of -1.801 and an adjusted p-value of 2.288e-05 in retinal pigment epithelium cells. Which cell type is this gene enriched in? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08890","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates multiple genes that are located in the plasma membrane. One such gene exhibits a log2 fold ch... | |
medium_hidden_intermediate_08891 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the maturation of SSU-rRNA. One of these genes exhibits a log2 fold change of 1.331 and an adjusted p-value of 0.0008582. Which protein is encoded by this specific gene? | Nucleolar complex protein 4 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08891","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the maturation of SSU... | |
medium_hidden_intermediate_08892 | In a study of lung cells, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to GABRA4. This specific gene exhibits a log2 fold change of 1.527 and an adjusted p-value of 0.004709. Which protein is encoded by this gene? | Sodium- and chloride-dependent betaine transporter | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08892","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to GABRA4... | |
medium_hidden_intermediate_08894 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in adherens junction interactions was found to have a log2 fold change of approximately 1.215 and an adjusted p-value of 5.184e-06. Which disease is associated with this specific gene? | severe combined immunodeficiency | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08894","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in adherens j... | |
medium_hidden_intermediate_08896 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a gene that participates in Signaling by Receptor Tyrosine Kinases. One such gene exhibited a log2 fold change of -1.195 and an adjusted p-value of 7.466e-05. Which protein is encoded by this specific gene? | Anosmin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08896","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a gene that ... | |
medium_hidden_intermediate_08898 | Hepacivirus C downregulates a specific gene, which in turn enables MHC protein binding. Experimental data for this gene in natural killer cells (from study GSE125686) reports a log2 fold change of approximately -1.076 and an adjusted p-value of 0.04444. Which protein is encoded by this gene? | T cell receptor gamma variable 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08898","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a specific gene, which in turn enables MHC protein binding. Experimental data for this gene in n... | |
medium_hidden_intermediate_08899 | Pegivirus C downregulates a gene that enables nuclear export signal receptor activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of approximately -1.96 and an adjusted p-value of 0.0027. Which protein does this specific gene interact with? | NUP62 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08899","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that enables nuclear export signal receptor activity. In a study of peripheral blood mononu... | |
medium_hidden_intermediate_08900 | Human alphaherpesvirus 1 upregulates a gene that participates in the Cell Cycle. Evidence for this specific gene reports a log2 fold change of 2.644 and an adjusted p-value of 0.01049. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08900","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in the Cell Cycle. Evidence for this specific gene reports a l... | |
medium_hidden_intermediate_08901 | A gene is downregulated by Cardiovirus A and enables identical protein binding. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.491 and an adjusted p-value of 0.00804. Which disease is associated with this gene? | cervical squamous cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08901","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and enables identical protein binding. Experimental data for this gene in a cervica... | |
medium_hidden_intermediate_08902 | Vaccinia virus infection is associated with the upregulation of specific genes that serve as biomarkers for breast carcinoma. One such gene exhibits a log2 fold change of approximately 1.627 and an adjusted p-value of 1.156e-05 in cervical adenocarcinoma cell lines. Which protein is encoded by this gene? | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08902","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection is associated with the upregulation of specific genes that serve as biomarkers for breast carcinoma... | |
medium_hidden_intermediate_08903 | Pegivirus C is reported to downregulate a specific gene that participates in GPCR downstream signalling. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -2.714 and an adjusted p-value of 0.0008756. Which disease is associated with this gene? | obesity disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08903","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that participates in GPCR downstream signalling. In a study of perip... | |
medium_hidden_intermediate_08904 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein-lysine N-methyltransferase activity. Experimental data for this gene reports a log2 fold change of 1.026 and an adjusted p-value of 0.01821. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08904","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein-lysine N-methyltransferas... | |
medium_hidden_intermediate_08906 | Human immunodeficiency virus 1 is reported to downregulate a specific gene, which is in turn enriched in naive B cells. Experimental data for this gene in macrophages (from study GSE108897) indicates a log2 fold change of approximately -1.31 and an adjusted p-value of 0.025. Which protein is encoded by this gene? | Protein sel-1 homolog 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08906","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 is reported to downregulate a specific gene, which is in turn enriched in naive B cells. Expe... | |
medium_hidden_intermediate_08908 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the response to elevated platelet cytosolic Ca2+. Evidence for this gene reports a log2 fold change of -1.062 and an adjusted p-value of 0.002079. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08908","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the response to elevate... | |
medium_hidden_intermediate_08909 | Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Experimental data for this gene in macrophages reports a log2 fold change of approximately 1.01 and an adjusted p-value of 0.001448. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08909","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of transcription by RNA polyme... | |
medium_hidden_intermediate_08910 | Two genes are structurally linked to Measles morbillivirus via an 'upregulates' relationship and to the process 'Transmission across Chemical Synapses' via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of 2.463 and an adjusted p-value of 0.001816. W... | CANX | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08910","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via an 'upregulates' relationship and to the process 'Transmissio... | |
medium_hidden_intermediate_08911 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for squamous cell carcinoma. Experimental data for this gene reports a log2 fold change of approximately 1.094 and an adjusted p-value of 0.001632. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08911","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for squamous cell c... | |
medium_hidden_intermediate_08915 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with breast carcinoma. One of these genes exhibits a log2 fold change of -1.233 and an adjusted p-value of 0.0001576 in lung tissue. Which biological process is this specific gene involved in? | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08915","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with breast carcinom... | |
medium_hidden_intermediate_08916 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene product that is involved in the response to UV radiation. This entity exhibits a log2 fold change of -2.465 and an adjusted p-value of 0.006209. Which protein is encoded by this gene? | Tumor protein p53-inducible protein 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08916","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of a specific g... | |
medium_hidden_intermediate_08917 | Hepacivirus C downregulates a specific gene product that is located in the mitochondrial inner membrane. In a study of peripheral blood mononuclear cells (GSE119117), this entity exhibited a log2 fold change of -2.853 and an adjusted p-value of 0.003231. Which molecular function is enabled by this entity? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08917","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a specific gene product that is located in the mitochondrial inner membrane. In a study of perip... | |
medium_hidden_intermediate_08918 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in the synthesis of phosphatidylcholine (PC). Experimental data for this gene reports a log2 fold change of approximately 2.525 and an adjusted p-value of 0.03456. Which protein is encoded by this gene? | Acetylcholinesterase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08918","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in the synthesis... | |
medium_hidden_intermediate_08920 | Two genes are structurally linked from Human betaherpesvirus 5 to mammary neoplasms, animal via a downregulates relationship followed by a biomarker relationship. One of these genes is reported in a study (GSE111036) with a log2 fold change of approximately -1.17 and an adjusted p-value of approximately 0.043. Which ce... | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08920","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human betaherpesvirus 5 to mammary neoplasms, animal via a downregulates relationship... | |
medium_hidden_intermediate_08921 | A gene is downregulated by Primate bocaparvovirus 1 and participates in Membrane Trafficking. Experimental evidence for this gene shows a log2 fold change of -2.290 and an adjusted p-value of 0.0003543. In which cell type is this gene enriched? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08921","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in Membrane Trafficking. Experimental evidence for this... | |
medium_hidden_intermediate_08922 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and onward to lung carcinoma via a 'biomarker' relationship. One of these genes has reported expression data showing a log2 fold change of approximately 2.227 and an adjusted p-value of 4.011e-... | acute myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08922","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationsh... | |
medium_hidden_intermediate_08924 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A upregulates a specific gene that participates in Viral Infection Pathways. This gene exhibits a log2 fold change of approximately 1.13 and an adjusted p-value of approximately 0.0075. Which biological process is this gene involved in? | 7-methylguanosine mRNA capping | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08924","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A upregulates a specific gene that participates in Viral Infec... | |
medium_hidden_intermediate_08925 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and its protein product interacts with YWHAH. One such gene exhibits a log2 fold change of approximately 1.265 and an adjusted p-value of 0.04084. Which protein is encoded by this specific gene? | Phosphatase and actin regulator 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08925","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and its protein... | |
medium_hidden_intermediate_08928 | Human betaherpesvirus 5 is reported to downregulate a gene that enables branched-chain amino acid:sodium symporter activity. In a study using foreskin fibroblast cell lines, one such gene exhibited a log2 fold change of -1.232 and an adjusted p-value of 0.03613. Which protein is encoded by this specific gene? | Sodium-dependent neutral amino acid transporter B(0)AT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08928","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that enables branched-chain amino acid:sodium symporter activity.... | |
medium_hidden_intermediate_08933 | Severe acute respiratory syndrome-related coronavirus upregulates a gene located in the chromosome centromeric region. Evidence for this specific gene reports a log2 fold change of 2.178 and an adjusted p-value of 0.04737. Which protein is encoded by this gene? | Borealin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08933","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene located in the chromosome centromeric region. Evide... | |
medium_hidden_intermediate_08934 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn encodes a protein that binds to VPS52. The expression data for this gene shows a log2 fold change of -1.998 and an adjusted p-value of 0.01158. What is the name of the protein encoded by this gene? | TATA element modulatory factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08934","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn e... | |
medium_hidden_intermediate_08935 | Measles morbillivirus upregulates a gene that participates in EGR2 and SOX10-mediated initiation of Schwann cell myelination. Evidence for one such gene reports a log2 fold change of 1.959 and an adjusted p-value of 0.01386. Which biological process is this gene involved in? | negative regulation of transcription by RNA polymerase III | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08935","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in EGR2 and SOX10-mediated initiation of Schwann cell myelination... | |
medium_hidden_intermediate_08936 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene involved in the glycoprotein biosynthetic process. One such gene exhibits a log2 fold change of 2.717 and an adjusted p-value of 0.00225. Which protein is encoded by this specific gene? | Galactose-3-O-sulfotransferase 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08936","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene involved in the glycoprotein biosyn... | |
medium_hidden_intermediate_08937 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of specific genes involved in the negative regulation of DNA-templated transcription. One such gene exhibits a log2 fold change of 1.280 and an adjusted p-value of 0.03657. Which cellular component is this specific gene ... | chromatin silencing complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08937","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of specific genes involv... | |
medium_hidden_intermediate_08939 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and enables GTPase activator activity. This specific gene exhibits a log2 fold change of approximately -1.52 and an adjusted p-value of approximately 0.0022. Which protein is encoded by this gene? | ELMO domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08939","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and enables GTPase acti... | |
medium_hidden_intermediate_08941 | A gene serves as a marker for Paneth cells and is enriched in neutrophils. Evidence for one such gene reports a mean expression of 161.99 TPM, a z-score of 2.44, and a fold enrichment of 3.56. Which disease is associated with genomic alterations in that specific gene? | rheumatoid arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08941","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Paneth cells and is enriched in neutrophils. Evidence for one such gene reports a mean express... | |
medium_hidden_intermediate_08943 | Enterovirus A is reported to upregulate a specific gene, which is in turn enriched in naive CD4+ T cells. Evidence for this gene in rhabdomyosarcoma cells (study GSE103308) indicates a log2 fold change of approximately 7.55 and an adjusted p-value of 0.036. Which protein is encoded by this gene? | Splicing regulator RBM11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08943","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to upregulate a specific gene, which is in turn enriched in naive CD4+ T cells. Evidence for this ... | |
medium_hidden_intermediate_08944 | Hepacivirus C downregulates a gene that enables G protein-coupled receptor binding. Experimental data for this gene shows a log2 fold change of -1.310 and an adjusted p-value of 5.701e-06. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08944","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that enables G protein-coupled receptor binding. Experimental data for this gene shows a ... | |
medium_hidden_intermediate_08946 | A genetic variant NM_015600.4(ABHD12):c.-6898_191+191+7002delinsCC is linked to a gene that interacts with EP300. Evidence regarding one such interacting partner states: 'This enhancement was due to direct protein-protein interactions of both pax-6 and cdx-2 with the N-terminal C/H1 domain of p300.' Which protein is en... | Homeobox protein CDX-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08946","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A genetic variant NM_015600.4(ABHD12):c.-6898_191+191+7002delinsCC is linked to a gene that interacts with EP300. Evidence r... | |
medium_hidden_intermediate_08948 | A specific gene serves as a marker for Natural killer T (NKT) cells and enables aminopeptidase activity. Evidence regarding this gene states: 'A proteome-based assay revealed that the gene product possesses previously unrecognized aminopeptidase activity but no carboxy- or endopeptidase activity.' Which biological proc... | peptide catabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08948","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene serves as a marker for Natural killer T (NKT) cells and enables aminopeptidase activity. Evidence regarding ... | |
medium_hidden_intermediate_08949 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that enables receptor ligand activity. This gene exhibited a log2 fold change of 2.788 and an adjusted p-value of 3.698e-07. Which protein is encoded by this gene? | T-lymphocyte activation antigen CD86 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08949","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_08952 | A gene is upregulated by Human gammaherpesvirus 8 and participates in Peptide hormone metabolism. Experimental evidence for this gene reports a log2 fold change of approximately 1.88 and an adjusted p-value of 0.047. Which protein is encoded by this gene? | Choriogonadotropin subunit beta 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08952","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and participates in Peptide hormone metabolism. Experimental evidence for ... | |
medium_hidden_intermediate_08954 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables 2-oxoglutarate-dependent dioxygenase activity. Evidence for one such gene reports a log2 fold change of 1.062 and an adjusted p-value of 0.001995. Which protein is encoded by that gene? | Probable RNA/DNA demethylase ALKBH6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08954","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables 2-oxoglutarate-dependent dioxygenase a... | |
medium_hidden_intermediate_08955 | Hepacivirus C is associated with the downregulation of a gene that participates in muscle contraction. Transcriptomic data for this gene shows a log2 fold change of -1.399 and an adjusted p-value of 0.0112. Which protein is encoded by this gene? | Voltage-dependent calcium channel gamma-4 subunit | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08955","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a gene that participates in muscle contraction. Transcriptomic data f... | |
medium_hidden_intermediate_08957 | Human betaherpesvirus 5 upregulates a gene that participates in Signaling by Interleukins. Experimental data for this gene reports a log2 fold change of approximately 3.43 and an adjusted p-value of approximately 0.024. Which cellular component is this gene located in? | cell surface | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08957","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in Signaling by Interleukins. Experimental data for this gene r... | |
medium_hidden_intermediate_08958 | Hepacivirus C downregulates a gene that is located in the cytosol. Evidence for one such gene reports a log2 fold change of -1.167 and an adjusted p-value of 0.01905. Which biological process is this gene involved in? | mitotic spindle organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08958","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that is located in the cytosol. Evidence for one such gene reports a log2 fold change of ... | |
medium_hidden_intermediate_08962 | Measles morbillivirus upregulates a gene that enables transcription cis-regulatory region binding. Evidence for one such gene reports a log2 fold change of 2.921 and an adjusted p-value of 0.02985. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08962","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that enables transcription cis-regulatory region binding. Evidence for one such gen... | |
medium_hidden_intermediate_08963 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are located in the recycling endosome. One of these genes exhibits a log2 fold change of approximately -1.38 and an adjusted p-value of approximately 0.0017 in a specific study. Which protein interacts with this specific gene? | B2M | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08963","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are located in the recycling endoso... | |
medium_hidden_intermediate_08964 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate certain genes located in the Golgi apparatus. One such gene exhibited a log2 fold change of -1.315 and an adjusted p-value of 0.02924. Which protein is encoded by this specific gene? | Lysosomal-associated transmembrane protein 4A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08964","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate certain gene... | |
medium_hidden_intermediate_08965 | Human betaherpesvirus 5 is reported to downregulate a gene that is associated with leukemia. In a study of foreskin fibroblast cell lines (GSE132081), one such gene exhibits a log2 fold change of approximately -3.77 and an adjusted p-value of approximately 0.0042. Which protein is encoded by this specific gene? | Tumor necrosis factor ligand superfamily member 18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08965","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is associated with leukemia. In a study of foreskin fibrobla... | |
medium_hidden_intermediate_08968 | Hepacivirus C downregulates a gene that participates in post-translational protein modification. Transcriptomic data for this gene in peripheral blood mononuclear cells (study GSE119117) shows a log2 fold change of -1.987 and an adjusted p-value of 0.003014. Which protein does this gene interact with? | SNAI1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08968","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that participates in post-translational protein modification. Transcriptomic data for thi... | |
medium_hidden_intermediate_08969 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated and its product is located in the phagocytic cup. Evidence for this gene reports a log2 fold change of 1.896 and an adjusted p-value of 0.01946. Which protein is encoded by this gene? | Bridging integrator 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08969","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated... | |
medium_hidden_intermediate_08971 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in plasma membrane tubulation. Experimental data for this gene reports a log2 fold change of -1.509 and an adjusted p-value of 0.04525. Which protein is encoded by this gene? | MICAL-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08971","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in plasma membrane tubulati... | |
medium_hidden_intermediate_08972 | The pretectal region overlaps with two distinct anatomical structures, both of which are ectoderm-derived. One of these structures is described as a nuclear complex located between the dorsal thalamus and the optic tectum, whose nuclei receive afferents primarily from the retina and the optic tectum and are involved in... | mesencephalic neural crest | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08972","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The pretectal region overlaps with two distinct anatomical structures, both of which are ectoderm-derived. One of these stru... | |
medium_hidden_intermediate_08974 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene that subsequently binds to LRP6. One such gene exhibited a log2 fold change of approximately -1.276 and an adjusted p-value of 0.002262. Which protein is encoded by this specific g... | Insulin-like growth factor-binding protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08974","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_08975 | A gene is upregulated by Human gammaherpesvirus 8 and participates in Signal Transduction. Experimental data for this gene reports a log2 fold change of approximately 1.184 and an adjusted p-value of 0.02163. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08975","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and participates in Signal Transduction. Experimental data for this gene r... | |
medium_hidden_intermediate_08976 | Hepacivirus C is reported to upregulate a gene that is associated with retinoblastoma. Experimental data for one such gene indicates a log2 fold change of approximately 1.081 and an adjusted p-value of 0.0003355. Which protein is encoded by this specific gene? | Mitochondrial tRNA methylthiotransferase CDK5RAP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08976","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is associated with retinoblastoma. Experimental data for one such gene i... | |
medium_hidden_intermediate_08977 | Human betaherpesvirus 5 is reported to upregulate a gene that subsequently interacts with STAU1. Experimental data for one such intermediate gene indicates a log2 fold change of 1.021 and an adjusted p-value of 0.02662. Which protein is encoded by this specific gene? | RNA-binding motif, single-stranded-interacting protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08977","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that subsequently interacts with STAU1. Experimental data for one s... | |
medium_hidden_intermediate_08979 | Human betaherpesvirus 5 downregulates a gene that participates in the metabolism of proteins. In a study of foreskin fibroblast cell lines (GSE111036), this gene exhibited a log2 fold change of -1.236 and an adjusted p-value of 0.04594. Which biological process is this gene involved in? | endoplasmic reticulum to Golgi vesicle-mediated transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08979","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that participates in the metabolism of proteins. In a study of foreskin fibrobl... | |
medium_hidden_intermediate_08980 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus and associated with protein tyrosine phosphatase activity was found to have a log2 fold change of -1.427 and an adjusted p-value of 0.04154. Which gene binds to this specific entity? | TUBA1B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08980","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus and associated with prot... | |
medium_hidden_intermediate_08981 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and subsequently to scavenger receptor activity via an 'enables' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.112 and an adjusted p-valu... | COLEC12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08981","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_08982 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene, which in turn encodes a protein located in the axoneme. The expression data for this gene shows a log2 fold change of approximately -1.59 and an adjusted p-value of 0.0001976. Which protein is enc... | Dynein regulatory complex protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08982","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene, ... | |
medium_hidden_intermediate_08984 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in visual perception. One of these genes exhibits a log2 fold change of -2.799 and an adjusted p-value of 0.0009045 in lung tissue. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08984","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in visual perception. ... | |
medium_hidden_intermediate_08985 | Zika virus downregulates a gene that enables GTPase activator activity. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -2.628 and an adjusted p-value of 0.009641. Which protein is encoded by this gene? | Protein ECT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08985","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables GTPase activator activity. In a study of glioma stem cells (GSE114907), one suc... | |
medium_hidden_intermediate_08986 | UBE2D4 interacts with a protein that enables protein binding. Biochemical characterization of recombinant versions of this protein and UBE2D demonstrated that they form a stable, stoichiometric complex that can be purified to near homogeneity. Which protein is encoded by the gene corresponding to this interacting partn... | Ubiquitin domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08986","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"UBE2D4 interacts with a protein that enables protein binding. Biochemical characterization of recombinant versions of this p... | |
medium_hidden_intermediate_08987 | Hepacivirus C upregulates a gene that is involved in the positive regulation of DNA-templated transcription. In a study of hepatocytes (GSE132606), this gene exhibited a log2 fold change of approximately 3.25 and an adjusted p-value of 1.176e-05. Which protein is encoded by this gene? | Protein Niban 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08987","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the positive regulation of DNA-templated transcription. In a study of h... | |
medium_hidden_intermediate_08988 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the cellular response to cAMP. One of these genes exhibits a log2 fold change of 1.059 and an adjusted p-value of 0.001133 in lung tissue. Which protein interacts with this specific gene? | USP15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08988","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the cellular response... | |
medium_hidden_intermediate_08989 | Zika virus downregulates a gene that is located in the mitochondrial outer membrane. Evidence for one such gene reports a log2 fold change of -1.729 and an adjusted p-value of 0.04747. Which disease is associated with genomic alterations in that specific gene? | testicular germ cell tumor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08989","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the mitochondrial outer membrane. Evidence for one such gene reports a lo... | |
medium_hidden_intermediate_08992 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in bone mineralization. One of these genes exhibits a log2 fold change of approximately 1.12 and an adjusted p-value of 0.006083 in a specific study. Which cellular component is the location of this specific gene? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08992","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in bone mineralization. ... | |
medium_hidden_intermediate_08994 | A gene is upregulated by Hepacivirus C and binds to MYD88. Evidence for this gene in peripheral blood mononuclear cells from study GSE119117 reports a log2 fold change of approximately 1.206 and an adjusted p-value of 0.01695. Which disease is genetically associated with this gene? | anxiety | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08994","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and binds to MYD88. Evidence for this gene in peripheral blood mononuclear cells from... | |
medium_hidden_intermediate_08995 | Zaire ebolavirus infection leads to the upregulation of certain genes that enable DNA binding. In a study of retinal pigment epithelium cells (GSE100839), one such upregulated gene exhibited a log2 fold change of 1.006 and an adjusted p-value of 0.01838. Which protein is encoded by this specific gene? | PiggyBac transposable element-derived protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08995","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of certain genes that enable DNA binding. In a study of retinal pigment... | |
medium_hidden_intermediate_08996 | Pegivirus C is associated with the downregulation of a gene that enables FAD binding. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.421 and an adjusted p-value of 0.00727. Which protein is encoded by this specific gene? | NADPH-dependent diflavin oxidoreductase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08996","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is associated with the downregulation of a gene that enables FAD binding. In a study of peripheral blood mononuc... | |
medium_hidden_intermediate_08997 | Human betaherpesvirus 5 is reported to downregulate a gene that subsequently interacts with RBBP4. Experimental data for one such gene in foreskin fibroblast cell lines indicates a log2 fold change of approximately -1.05 and an adjusted p-value of approximately 0.007. Which protein is encoded by this specific gene? | Zinc finger protein 827 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08997","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that subsequently interacts with RBBP4. Experimental data for one... | |
medium_hidden_intermediate_08998 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables kinase binding. Experimental data for this gene in lung cells reports a log2 fold change of approximately -1.019 and an adjusted p-value of 0.02015. Which disease is associated with this gene as a biomarker? | nephrotic syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_08998","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables kinase binding. Experimental da... | |
medium_hidden_intermediate_09000 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with HSP90AA1. Evidence for one such gene reports a log2 fold change of 1.194 and an adjusted p-value of 5.648e-15. Which protein is encoded by that gene? | Guanylate cyclase soluble subunit beta-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09000","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with HSP90AA1. Evidence for one such... | |
medium_hidden_intermediate_09001 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Neuronal System. Experimental data for this gene shows a log2 fold change of -1.631 and an adjusted p-value of 0.04843. What molecular function does this gene enable? | delayed rectifier potassium channel activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09001","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Neuronal System. Ex... | |
medium_hidden_intermediate_09002 | Two genes are downregulated by Pegivirus C and interact with C1QBP. One of these genes exhibits a log2 fold change of -1.463 and an adjusted p-value of 0.01989 in peripheral blood mononuclear cells. Which cellular component is this specific gene located in? | nucleolus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09002","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and interact with C1QBP. One of these genes exhibits a log2 fold change of -1.463... | |
medium_hidden_intermediate_09005 | Zika virus downregulates a gene that is located in the Golgi membrane. Evidence from a study on glioma stem cells (GSE114907) reports that this gene has a log2 fold change of approximately -1.24 and an adjusted p-value of approximately 0.0305. Which protein is encoded by this gene? | Protein lifeguard 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09005","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the Golgi membrane. Evidence from a study on glioma stem cells (GSE114907... | |
medium_hidden_intermediate_09007 | HOXA1 is involved in a biological process that is a type of anatomical structure development. Evidence for one such process describes the progression of the cochlea from its formation to its mature structure, noting that the cochlea is the snail-shaped portion of the inner ear responsible for sound detection. Which bio... | inner ear development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09007","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"HOXA1 is involved in a biological process that is a type of anatomical structure development. Evidence for one such process ... | |
medium_hidden_intermediate_09008 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with endometrial carcinoma. One of these genes exhibits a log2 fold change of -1.476 and an adjusted p-value of 0.01718 in a specific study. Which biological process is this gene involved in? | potassium ion transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09008","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with endometrial car... | |
medium_hidden_intermediate_09009 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that are located in the extracellular region. One such gene exhibited a log2 fold change of approximately 1.97 and an adjusted p-value of 0.0001397. Which biological process is this specific gene ... | positive regulation of cell population proliferation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09009","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_09010 | Human alphaherpesvirus 1 upregulates a gene that subsequently binds to FANCL. In a study of monocytic leukemia cell lines (GSE114966), one such intermediate gene was found to have a log2 fold change of 1.706 and an adjusted p-value of 0.003694. Which protein is encoded by this specific gene? | Structure-specific endonuclease subunit EME1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09010","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that subsequently binds to FANCL. In a study of monocytic leukemia cell lines (G... | |
medium_hidden_intermediate_09013 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to interact with YWHAH exhibits a log2 fold change of approximately 1.183 and an adjusted p-value of 0.0001551. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09013","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to interact with... | |
medium_hidden_intermediate_09014 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the post-translational modification: synthesis of GPI-anchored proteins. One of these genes exhibits a log2 fold change of 1.777 and an adjusted p-value of 0.04843 in a specific study. Which gene interacts with the gen... | ANLN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09014","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the post-translational... | |
medium_hidden_intermediate_09015 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the trans-Golgi network. One of these genes exhibits a log2 fold change of 1.618 and an adjusted p-value of 4.007e-05 in a specific study. Which disease is associated with this gene as a biomarker? | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09015","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the trans-Golgi networ... | |
medium_hidden_intermediate_09017 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with ZC3HAV1. One of these genes exhibits a log2 fold change of approximately 1.006 and an adjusted p-value of 0.01708 in a specific study. Which protein is encoded by this gene? | YTH domain-containing family protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09017","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with ZC3HAV1. One of these g... | |
medium_hidden_intermediate_09018 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved in the positive regulation of double-strand break repair. Evidence for this gene reports a log2 fold change of 1.122 and an adjusted p-value of 0.0003456. Which protein is encoded by this gene? | SMC5-SMC6 complex localization factor protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09018","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved i... | |
medium_hidden_intermediate_09019 | Measles morbillivirus upregulates a gene that participates in the Innate Immune System. Evidence for this gene reports a log2 fold change of approximately 1.04 and an adjusted p-value of approximately 0.0047. Which protein does this gene product bind to? | PANX2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09019","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the Innate Immune System. Evidence for this gene reports a log... | |
medium_hidden_intermediate_09020 | In a study of cardiomyocyte cell lines (GSE151879), a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SUV39H1. This specific gene exhibits a log2 fold change of approximately 1.252 and an adjusted p-value of 0.008266. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09020","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), a gene is upregulated by Severe acute respiratory syndrome-related coron... | |
medium_hidden_intermediate_09021 | Human immunodeficiency virus 1 upregulates a gene that is located in the perinuclear region of the cytoplasm. Evidence for one such gene reports a log2 fold change of 1.284 and an adjusted p-value of 0.00573. Which disease is associated with this gene as a biomarker? | toxoplasmosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09021","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the perinuclear region of the cytoplasm. Evidence for o... | |
medium_hidden_intermediate_09022 | Measles morbillivirus upregulates a gene that interacts with HSP90AA1. Experimental data for one such gene reports a log2 fold change of approximately 1.058 and an adjusted p-value of 0.005031. Which protein is encoded by this gene? | Calcyclin-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09022","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with HSP90AA1. Experimental data for one such gene reports a log2 fo... | |
medium_hidden_intermediate_09024 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn enables chromatin binding. This gene exhibits a log2 fold change of -1.408 and an adjusted p-value of 0.03081. Which protein is encoded by this downregulated gene? | Histone PARylation factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09024","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_09027 | Severe acute respiratory syndrome-related coronavirus downregulates a specific gene, which is involved in the negative regulation of viral genome replication. Experimental data for this gene reports a log2 fold change of -1.021 and an adjusted p-value of 0.03897. Which protein is encoded by this gene? | Interferon-induced transmembrane protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09027","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a specific gene, which is involved in the negative regul... | |
medium_hidden_intermediate_09028 | Hepacivirus C upregulates a gene that subsequently binds to ACVR2A. Experimental data for one such intermediate gene reports a log2 fold change of 1.583 and an adjusted p-value of 0.02717. Which disease is associated with this intermediate gene as a biomarker? | tuberous sclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09028","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that subsequently binds to ACVR2A. Experimental data for one such intermediate gene reports... | |
medium_hidden_intermediate_09029 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and interacts with IRS4. This specific gene exhibits a log2 fold change of -1.173 and an adjusted p-value of 0.01289. Which protein is encoded by this gene? | Serine/threonine-protein kinase A-Raf | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09029","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and interacts with IR... | |
medium_hidden_intermediate_09030 | Zika virus downregulates a specific gene, which in turn interacts with UBC. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -3.514 and an adjusted p-value of 0.01847. Which disease is associated with this gene through genomic alterations? | major affective disorder 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09030","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with UBC. Experimental data for this gene in glioma stem c... |
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