qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_hidden_intermediate_09031 | A gene interacts with YWHAQ and is enriched in memory CD8+ T cells. Evidence for this gene reports a mean expression of 44.70 TPM, a z-score of 2.49, and a fold enrichment of 10.07. Which disease is associated with this gene as a biomarker? | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09031","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene interacts with YWHAQ and is enriched in memory CD8+ T cells. Evidence for this gene reports a mean expression of 44.7... | |
medium_hidden_intermediate_09032 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and serves as a biomarker for mammary neoplasms in animals. This specific gene exhibits a log2 fold change of approximately -3.21 and an adjusted p-value of 0.006. Which protein is encoded by this gene? | P2X purinoceptor 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09032","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and serv... | |
medium_hidden_intermediate_09034 | A specific gene product forms a complex with CUL3 and participates in protein ubiquitination. Experimental evidence indicates that this entity binds DAPK and Cullin 3 (Cul3) via its Kelch-repeat domain and BTB domain, respectively. Which protein is encoded by this gene? | Kelch-like protein 20 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09034","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene product forms a complex with CUL3 and participates in protein ubiquitination. Experimental evidence indicate... | |
medium_hidden_intermediate_09037 | Hepacivirus C upregulates a gene that is involved in small GTPase-mediated signal transduction. Evidence for one such gene reports a log2 fold change of approximately 1.20 and an adjusted p-value of approximately 0.0042. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09037","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in small GTPase-mediated signal transduction. Evidence for one such gene r... | |
medium_hidden_intermediate_09038 | A gene is downregulated by Hepacivirus C and participates in the G0 and Early G1 cell cycle phases. Experimental data for this gene reports a log2 fold change of -1.352 and an adjusted p-value of 0.01451. Which disease is associated with this gene through genomic alterations? | acute myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09038","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Hepacivirus C and participates in the G0 and Early G1 cell cycle phases. Experimental data for th... | |
medium_hidden_intermediate_09042 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in cell surface interactions at the vascular wall. Evidence for one such gene reports a log2 fold change of 1.656 and an adjusted p-value of 0.02818. Which protein is encoded by that gene? | Junctional adhesion molecule-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09042","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in cell surface interactions at t... | |
medium_hidden_intermediate_09043 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to DNA-binding transcription repressor activity, RNA polymerase II-specific via an enables relationship. One of these genes is associated with experimental data showing a log2 fold change of a... | Zinc finger protein 140 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09043","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_09044 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that subsequently interact with the protein CANX. One such gene exhibited a log2 fold change of approximately 1.369 and an adjusted p-value of 8.876e-06. Which protein is encoded by this specific ... | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09044","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_09045 | Human immunodeficiency virus 1 downregulates a gene that is enriched in naive B cells. Evidence for this gene in macrophages reports a log2 fold change of -2.282 and an adjusted p-value of 0.006001. Which protein is encoded by this gene? | Synaptotagmin-17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09045","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is enriched in naive B cells. Evidence for this gene in macrophages... | |
medium_hidden_intermediate_09046 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn is associated with GTP binding activity. This gene exhibits a log2 fold change of -1.482 and an adjusted p-value of 0.008389. What is the name of the protein encoded by thi... | ADP-ribosylation factor-like protein 4A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09046","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_09048 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Alpha-oxidation of phytanate. One of these genes shows a log2 fold change of 1.539 and an adjusted p-value of 0.01094 in a specific study. Which cell type is enriched for that specific gene? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09048","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Alpha-oxidation of phy... | |
medium_hidden_intermediate_09050 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables DNA-binding transcription activator activity, RNA polymerase II-specific. Evidence for this gene reports a log2 fold change of 1.051 and an adjusted p-value of 0.03237. Which protein is encoded by this gene? | ETS domain-containing protein Elk-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09050","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables DNA-binding transcription activator ac... | |
medium_hidden_intermediate_09051 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to bipolar disorder via biomarker association. One of these genes exhibits a log2 fold change of 3.259 and an adjusted p-value of 8.146e-08. Which protein is encoded by this specific gene? | Neurosecretory protein VGF | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09051","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to bipolar disorder via b... | |
medium_hidden_intermediate_09053 | Two distinct biological processes are linked to 'cranial ganglion maturation' via a 'part of' relationship and subsequently linked to 'cranial nerve development' via another 'part of' relationship. One of these intermediate processes is defined by evidence stating it is a developmental process, independent of morphogen... | ganglion development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09053","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct biological processes are linked to 'cranial ganglion maturation' via a 'part of' relationship and subsequently ... | |
medium_hidden_intermediate_09056 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the Golgi membrane. Evidence for this gene reports a log2 fold change of 1.387 and an adjusted p-value of 0.008272. Which protein is encoded by this gene? | Protein lifeguard 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09056","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the Golgi membrane. Evidence for... | |
medium_hidden_intermediate_09059 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in RNA metabolism. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene has a log2 fold change of approximately -1.073 and an adjusted p-value of 0.0202. Which protein is encoded by t... | FAST kinase domain-containing protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09059","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in RNA metabolism. Experimental data fro... | |
medium_hidden_intermediate_09060 | Zika virus downregulates a specific gene, which is involved in the positive regulation of cell population proliferation. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.52 and an adjusted p-value of 0.0259. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09060","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which is involved in the positive regulation of cell population proliferation. In ... | |
medium_hidden_intermediate_09062 | CSTF2 interacts with a protein that enables protein binding. Evidence indicates that this protein is bound to the concave face of symplekin, and engineered mutations in this interface can abolish interactions between the two proteins. Which gene encodes this protein? | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09062","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CSTF2 interacts with a protein that enables protein binding. Evidence indicates that this protein is bound to the concave fa... | |
medium_hidden_intermediate_09063 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with CEP135. This gene exhibited a log2 fold change of approximately -1.53 and an adjusted p-value of approximately 0.0166. Which protein is encoded by this gene? | Migration and invasion-inhibitory protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09063","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_09064 | Human alphaherpesvirus 3 upregulates multiple genes that are located in the plasma membrane. One such gene exhibits a log2 fold change of 1.032 and an adjusted p-value of 2.806e-05 in melanoma cell lines. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09064","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates multiple genes that are located in the plasma membrane. One such gene exhibits a log2 f... | |
medium_hidden_intermediate_09065 | Measles morbillivirus upregulates a gene that is involved in intracellular signal transduction. Evidence for one such gene reports a log2 fold change of 1.795 and an adjusted p-value of 0.0003024. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09065","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in intracellular signal transduction. Evidence for one such gene r... | |
medium_hidden_intermediate_09067 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with lung carcinoma. Experimental data for this gene reports a log2 fold change of 1.695 and an adjusted p-value of 0.009947. Which disease is connected to this gene through genomic alterations? | coronary artery disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09067","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with lung carcinoma. Experi... | |
medium_hidden_intermediate_09068 | Hepacivirus C is reported to downregulate a specific gene, which in turn participates in Signaling by Interleukins. Experimental data for this gene shows a log2 fold change of -1.437 and an adjusted p-value of 0.0007164. Which protein is encoded by this gene? | C-C motif chemokine 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09068","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which in turn participates in Signaling by Interleukins. Experime... | |
medium_hidden_intermediate_09069 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with invasive breast carcinoma. One of these genes exhibits a log2 fold change of 4.665 and an adjusted p-value of 0.01342 in a specific study. Which protein is encoded by this gene? | Pirin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09069","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with invasive breast c... | |
medium_hidden_intermediate_09070 | Enterovirus A is reported to downregulate a specific gene that is located in the cytosol. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) show a log2 fold change of approximately -1.004 and an adjusted p-value of 0.003548. Which cell type is this gene enriched in? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09070","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene that is located in the cytosol. Experimental data for this gene in... | |
medium_hidden_intermediate_09071 | Hepacivirus C upregulates a gene that enables transcription corepressor activity. Experimental data from study GSE132606 in hepatocytes indicates that one such gene has a log2 fold change of 2.420 and an adjusted p-value of 0.000573. Which protein is encoded by this specific gene? | Zinc finger protein 653 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09071","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables transcription corepressor activity. Experimental data from study GSE132606 in ... | |
medium_hidden_intermediate_09075 | Two genes are upregulated by Vaccinia virus and associated with colon carcinoma. One of these genes exhibits a log2 fold change of approximately 3.67 and an adjusted p-value of approximately 2.24e-11 in cervical adenocarcinoma cell lines. Which disease is linked to this specific gene via a biomarker relationship? | benign neoplasm of large intestine | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09075","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with colon carcinoma. One of these genes exhibits a log2 fold cha... | |
medium_hidden_intermediate_09077 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the extracellular matrix. Experimental data for this gene reports a log2 fold change of 1.544 and an adjusted p-value of 0.0006155. Which disease is associated with this gene through genomic alterations? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09077","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the extracellular matrix. E... | |
medium_hidden_intermediate_09078 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables hormone activity. Transcriptomic data for this gene reports a log2 fold change of 1.242 and an adjusted p-value of 0.003533. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09078","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables hormone activity. Transcriptomic ... | |
medium_hidden_intermediate_09080 | A gene expressed in Natural killer T cells and localized to the mitochondrial inner membrane is described by evidence stating: 'Both human complexes are tightly associated with the inner membrane and, compared with yeast, soluble 70-kDa complexes appear to be completely absent in the intermembrane space.' Which biologi... | protein insertion into mitochondrial inner membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09080","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene expressed in Natural killer T cells and localized to the mitochondrial inner membrane is described by evidence statin... | |
medium_hidden_intermediate_09084 | A gene serves as a marker for microglial cells and is also enriched in eosinophils. Evidence for one such gene reports a mean expression of 14.09 TPM, a z-score of 1.55, and a fold enrichment of 3.47. Which disease is associated with this gene as a biomarker? | obesity disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09084","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for microglial cells and is also enriched in eosinophils. Evidence for one such gene reports a mea... | |
medium_hidden_intermediate_09085 | Zika virus upregulates a specific gene that is enriched in non-classical monocytes. Experimental data for this gene reports a log2 fold change of approximately 1.064 and an adjusted p-value of 0.02683. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09085","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene that is enriched in non-classical monocytes. Experimental data for this gene reports ... | |
medium_hidden_intermediate_09086 | Two genes are upregulated by Vaccinia virus and associated with neuroblastoma. One of these genes exhibits a log2 fold change of 2.073 and an adjusted p-value of 6.42e-05 in cervical adenocarcinoma cell lines (study GSE11238). What molecular function is enabled by this specific gene? | [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09086","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with neuroblastoma. One of these genes exhibits a log2 fold chang... | |
medium_hidden_intermediate_09089 | Influenza A virus upregulates a gene that is located in the extracellular exosome. Evidence for one such gene reports a log2 fold change of 1.064 and an adjusted p-value of 1.062e-06. Which protein does this gene product bind to? | VTA1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09089","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus upregulates a gene that is located in the extracellular exosome. Evidence for one such gene reports a log2... | |
medium_hidden_intermediate_09090 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which subsequently interacts with HSPA5. This gene exhibits a log2 fold change of approximately 1.123 and an adjusted p-value of 0.002092. In which cellular component is this upregulated gene located? | endoplasmic reticulum membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09090","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_09091 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lymphoma. One of these genes exhibits a log2 fold change of approximately -1.39 and an adjusted p-value of approximately 0.0203 in a specific study. Which biological process is this gene involved in? | positive regulation of membrane potential | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09091","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lymphoma. One o... | |
medium_hidden_intermediate_09092 | Pegivirus C downregulates a specific gene, which in turn interacts with RBBP4. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) reports a log2 fold change of approximately -1.238 and an adjusted p-value of approximately 0.0035. Which cellular component is this in... | NURF complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09092","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, which in turn interacts with RBBP4. Experimental data for this intermediate gene ... | |
medium_hidden_intermediate_09094 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of transcription by RNA polymerase II. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene exhibits a log2 fold change of approximately -2.37 and an ad... | TP53 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09094","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of transc... | |
medium_hidden_intermediate_09095 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene involved in the ceramide metabolic process. One such gene exhibited a log2 fold change of 1.149 and an adjusted p-value of 0.0009877. Which protein is encoded by this specific gene? | Ceramide kinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09095","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene involved in the cer... | |
medium_hidden_intermediate_09097 | Hepacivirus C is reported to upregulate a gene that participates in GPCR downstream signalling. Experimental data for one such gene shows a log2 fold change of 4.164 and an adjusted p-value of 0.00519. Which disease is associated with this gene as a biomarker? | eclampsia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09097","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that participates in GPCR downstream signalling. Experimental data for one su... | |
medium_hidden_intermediate_09098 | Two genes serve as markers in mitotic fetal germ cells and are both involved in mitochondrial magnesium ion transmembrane transport. One of these genes is described in the literature with the statement: 'We conclude that hMrs2 is the major transport protein for Mg (+) uptake into mitochondria.' Which protein is encoded... | Magnesium transporter MRS2 homolog, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09098","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes serve as markers in mitotic fetal germ cells and are both involved in mitochondrial magnesium ion transmembrane tr... | |
medium_hidden_intermediate_09099 | Zaire ebolavirus downregulates a gene that is involved in the cell surface receptor signaling pathway. In a study of retinal pigment epithelium cells (GSE100839), one such gene exhibited a log2 fold change of approximately -1.266 and an adjusted p-value of 0.001728. Which protein is encoded by this specific gene? | Docking protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09099","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that is involved in the cell surface receptor signaling pathway. In a study of retinal... | |
medium_hidden_intermediate_09100 | Zika virus downregulates a gene that participates in tRNA modification in the nucleus and cytosol. In glioma stem cells, one such gene exhibits a log2 fold change of -1.625 and an adjusted p-value of 0.01257. Which protein is encoded by this gene? | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09100","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in tRNA modification in the nucleus and cytosol. In glioma stem cells, one... | |
medium_hidden_intermediate_09101 | Zika virus downregulates a gene that is involved in cilium assembly. Transcriptomic data from glioma stem cells (study GSE114907) indicates that one such gene has a log2 fold change of -1.534 and an adjusted p-value of 0.006011. Which protein interacts with this specific gene product? | CEP19 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09101","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in cilium assembly. Transcriptomic data from glioma stem cells (study GSE11... | |
medium_hidden_intermediate_09103 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with ANLN. One of these genes has a reported log2 fold change of -1.807 and an adjusted p-value of 0.04128. Which protein is encoded by this specific gene? | Hornerin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09103","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with ANLN. One of these ge... | |
medium_hidden_intermediate_09105 | Hepacivirus C upregulates a gene that is involved in cell-cell adhesion. Evidence for one such gene reports a log2 fold change of 1.831 and an adjusted p-value of 0.001294. Which protein is encoded by that gene? | Fibroblast growth factor receptor-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09105","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in cell-cell adhesion. Evidence for one such gene reports a log2 fold chan... | |
medium_hidden_intermediate_09106 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in SLC-mediated transmembrane transport. One such gene exhibits a log2 fold change of 1.977 and an adjusted p-value of 0.0004651. Which protein is encoded by this specific gene? | Anion exchange protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09106","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in SLC-mediated t... | |
medium_hidden_intermediate_09107 | Human gammaherpesvirus 4 is known to downregulate a specific gene that participates in lipid metabolism. In a study of gamma delta T-lymphocytes (GSE13906), this gene exhibited a log2 fold change of approximately -1.053 and an adjusted p-value of 0.02096. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09107","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human gammaherpesvirus 4 is known to downregulate a specific gene that participates in lipid metabolism. In a study of gamma... | |
medium_hidden_intermediate_09108 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Diseases of signal transduction by growth factor receptors and second messengers. Experimental evidence for this gene reports a log2 fold change of 2.613 and an adjusted p-value of 0.001158. Which cellular component is th... | TORC2 complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09108","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Diseases of signal transd... | |
medium_hidden_intermediate_09109 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Nuclear RNA decay. One of these genes shows a log2 fold change of approximately 1.344 and an adjusted p-value of 0.008715 in a specific study. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09109","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Nuclear RNA decay. One... | |
medium_hidden_intermediate_09110 | Hepacivirus C is reported to downregulate a gene whose protein product is located in the Golgi apparatus. In a study of peripheral blood mononuclear cells (GSE119117), one such gene showed a log2 fold change of -1.044 and an adjusted p-value of 0.03861. Which protein is encoded by this specific gene? | Sorting nexin-17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09110","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene whose protein product is located in the Golgi apparatus. In a study of peri... | |
medium_hidden_intermediate_09114 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection leads to the downregulation of certain genes involved in the positive regulation of vascular associated smooth muscle cell proliferation. One such gene exhibits a log2 fold change of approximately -2.095 and an adjusted p-value of 0.0... | Insulin-like growth factor-binding protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09114","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection leads to the downregulation of certain... | |
medium_hidden_intermediate_09115 | Two genes are structurally linked to Human gammaherpesvirus 4 via a 'downregulates' relationship and to 'negative regulation of transcription by RNA polymerase II' via an 'involved in' relationship. One of these genes has a reported log2 fold change of -2.288 and an adjusted p-value of 0.04433 in gamma delta T-lymphocy... | acute myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09115","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human gammaherpesvirus 4 via a 'downregulates' relationship and to 'negative regulation... | |
medium_hidden_intermediate_09116 | Human betaherpesvirus 5 upregulates a gene that enables enzyme binding. Evidence for this gene reports a log2 fold change of approximately 3.22 and an adjusted p-value of approximately 0.0009. Which disease is associated with this gene as a biomarker? | lung adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09116","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that enables enzyme binding. Evidence for this gene reports a log2 fold change of... | |
medium_hidden_intermediate_09118 | Two genes are structurally linked to Vaccinia virus via downregulation and to retinitis pigmentosa via association. One of these genes exhibits a log2 fold change of approximately -1.19 and an adjusted p-value of approximately 0.0006 in cervical adenocarcinoma cell lines (study GSE11238). Which biological process is th... | regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09118","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Vaccinia virus via downregulation and to retinitis pigmentosa via association. One of t... | |
medium_hidden_intermediate_09119 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the cellular response to acidic pH. One of these genes shows a log2 fold change of 1.141 and an adjusted p-value of 0.003728 in monocytes. Which disease is associated with this specific gene as a biomarker? | multiple sclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09119","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the cellular response... | |
medium_hidden_intermediate_09120 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its product interacts with NEDD8. Evidence for this gene reports a log2 fold change of -1.188 and an adjusted p-value of 0.0001288. Which protein is encoded by this gene? | Ankyrin repeat domain-containing protein 13D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09120","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its prod... | |
medium_hidden_intermediate_09122 | Hepacivirus C is reported to upregulate a gene that is involved in the positive regulation of protein phosphorylation. Experimental data for this gene in natural killer cells shows a log2 fold change of approximately 1.43 and an adjusted p-value of 0.0178. Which protein is encoded by this gene? | Fatty acid hydroxylase domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09122","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is involved in the positive regulation of protein phosphorylation. Exper... | |
medium_hidden_intermediate_09123 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with YWHAB. One of these genes exhibits a log2 fold change of -1.739 and an adjusted p-value of 0.04103 in a specific study. Which biological process is this specific gene involved in? | negative regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09123","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with YWHAB. One of these g... | |
medium_hidden_intermediate_09125 | Pegivirus C is reported to downregulate a specific gene that participates in rRNA processing in the nucleus and cytosol. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.728 and an adjusted p-value of 0.02083. Which disease is associated with this gene? | benign neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09125","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that participates in rRNA processing in the nucleus and cytosol. In ... | |
medium_hidden_intermediate_09128 | Zika virus downregulates multiple genes involved in mRNA splicing via the spliceosome. One such gene exhibits a log2 fold change of -2.240 and an adjusted p-value of 0.04124 in glioma stem cells. Which gene interacts with this specific downregulated entity? | SRRM4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09128","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes involved in mRNA splicing via the spliceosome. One such gene exhibits a log2 fold ch... | |
medium_hidden_intermediate_09129 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that participates in the Cell Cycle. This specific gene exhibited a log2 fold change of 3.274 and an adjusted p-value of 2.531e-06. Which protein is encoded by this gene? | Transcription factor E2F2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09129","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that pa... | |
medium_hidden_intermediate_09130 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn participates in neutrophil degranulation. This gene exhibited a log2 fold change of approximately 1.915 and an adjusted p-value of 1.458e-07. Which protein is encoded by this gene... | Acylamino-acid-releasing enzyme | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09130","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_09133 | Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and enriched in Gamma delta(γδ) T cells. One of these genes exhibits a log2 fold change of -2.040 and an adjusted p-value of 0.002538 in a specific study. Which protein does this specific gene bind to? | RICTOR | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09133","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and enriched in Gamma delta(γδ) T ... | |
medium_hidden_intermediate_09135 | Human betaherpesvirus 5 upregulates a gene that is involved in the immune response. Evidence for one such gene reports a log2 fold change of 2.315 and an adjusted p-value of 0.004219. Which protein is encoded by that gene? | Secreted and transmembrane protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09135","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is involved in the immune response. Evidence for one such gene reports a log... | |
medium_hidden_intermediate_09137 | Cyproheptadine and Ifosfamide are both known to interact with a specific intermediate drug. Evidence indicates that while p-Chlorophenylalanine and methergoline had no effect, cyproheptadine enhanced the anticonvulsive action of most benzodiazepines tested. Based on this evidence, which disease is the intermediate drug... | anxiety | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09137","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cyproheptadine and Ifosfamide are both known to interact with a specific intermediate drug. Evidence indicates that while p-... | |
medium_hidden_intermediate_09138 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and participates in the activation of BH3-only proteins. Evidence for this gene reports a log2 fold change of approximately 1.12 and an adjusted p-value of 0.004378. Which protein is encoded by this ge... | Apoptosis-stimulating of p53 protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09138","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and p... | |
medium_hidden_intermediate_09139 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. This specific gene exhibited a log2 fold change of approximately 1.052 and an adjusted p-value of 0.002987. Which protein is encoded... | Speckle-type POZ protein-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09139","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene involved in the pro... | |
medium_hidden_intermediate_09141 | Vaccinia virus upregulates a specific gene, which in turn participates in a disease. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately 2.27 and an adjusted p-value of approximately 1.39e-07. Which disease is associated with this ... | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09141","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a specific gene, which in turn participates in a disease. Experimental data from a cervical adeno... | |
medium_hidden_intermediate_09142 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in potassium ion transport. Experimental data for this gene reports a log2 fold change of -1.631 and an adjusted p-value of 0.04843. Which disease is associated with this gene as a biomarker? | liver cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09142","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in potassium ion transport.... | |
medium_hidden_intermediate_09143 | Human alphaherpesvirus 1 downregulates a gene that participates in Metabolism. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of -1.023 and an adjusted p-value of 0.007482. Which biological process is this gene involved in? | phosphatidylcholine acyl-chain remodeling | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09143","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 downregulates a gene that participates in Metabolism. Evidence for this gene in a monocytic leukemi... | |
medium_hidden_intermediate_09145 | Human immunodeficiency virus 1 downregulates a gene that interacts with STK4. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of -1.204 and an adjusted p-value of 0.02003. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09145","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that interacts with STK4. Evidence for this gene in macrophages (from st... | |
medium_hidden_intermediate_09146 | Zika virus downregulates a gene whose product is located in the extracellular region. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -3.427 and an adjusted p-value of 0.03203. Which protein is encoded by this gene? | Extracellular tyrosine-protein kinase PKDCC | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09146","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene whose product is located in the extracellular region. In a study of glioma stem cells (GSE11... | |
medium_hidden_intermediate_09147 | Human immunodeficiency virus 1 upregulates a gene that interacts with UBE2I. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately 4.25 and an adjusted p-value of approximately 0.01. Which protein is encoded by this specific gene? | Bis(5'-adenosyl)-triphosphatase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09147","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that interacts with UBE2I. In a study of macrophages (GSE108897), one such... | |
medium_hidden_intermediate_09150 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and is known to be involved in mitotic cytokinesis. This gene exhibits a log2 fold change of approximately 1.588 and an adjusted p-value of 7.926e-10. Which protein is encoded by this gene? | MIT domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09150","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_09151 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated by the virus and its product enables NAD binding. Evidence for this gene reports a log2 fold change of -2.256 and an adjusted p-value of 0.0005311. Which protein is encoded by this gene? | Dehydrogenase/reductase SDR family member 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09151","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated by the virus... | |
medium_hidden_intermediate_09152 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables metallopeptidase activity. Experimental data for this gene shows a log2 fold change of -3.583 and an adjusted p-value of 0.03917. Which cellular component is this gene located in? | extracellular matrix | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09152","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables metallopeptidase activity. Expe... | |
medium_hidden_intermediate_09153 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of specific genes located in the cytosol. One such gene exhibits a log2 fold change of approximately 1.094 and an adjusted p-value of 0.009068. Which biological process is this specific gene involved in? | nuclear-transcribed mRNA catabolic process, non-stop decay | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09153","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of specific genes locate... | |
medium_hidden_intermediate_09155 | In a study of natural killer cells (GSE125686), a gene is identified as being upregulated by Human immunodeficiency virus 1 and serving as a biomarker for autism spectrum disorder. This specific gene exhibits a log2 fold change of 1.677 and an adjusted p-value of 0.01917. Which protein is encoded by this gene? | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09155","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of natural killer cells (GSE125686), a gene is identified as being upregulated by Human immunodeficiency virus 1 ... | |
medium_hidden_intermediate_09156 | A protein is expressed in Natural killer T cells and physically interacts with PES1. Experimental evidence indicates that this protein co-immunoprecipitates with WDR12 and is incorporated into the PeBoW complex. Which protein is encoded by the gene corresponding to this entity? | Ribosome biogenesis protein BOP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09156","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein is expressed in Natural killer T cells and physically interacts with PES1. Experimental evidence indicates that th... | |
medium_hidden_intermediate_09157 | Pegivirus C is reported to downregulate a specific gene, which in turn is associated with a protein-containing complex. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) indicates a log2 fold change of -1.346 and an adjusted p-value of 0.003082. Which protein is encoded by thi... | Methyltransferase-like protein 22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09157","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn is associated with a protein-containing complex. Expe... | |
medium_hidden_intermediate_09158 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to cilium assembly via an 'involved in' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.756 and an adjusted p-value of 4.299e-05. Which... | Alpha-parvin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09158","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_09161 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the metabolism of vitamins and cofactors. Evidence for this gene reports a log2 fold change of 1.085 and an adjusted p-value of 0.0002868. Which molecular function is enabled by this gene? | FAD transmembrane transporter activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09161","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the metabolism of vitamins and... | |
medium_hidden_intermediate_09162 | Zika virus downregulates a specific gene that participates in the formation of WDR5-containing histone-modifying complexes. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.196 and an adjusted p-value of 0.01363. Which disease is associated with this ... | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09162","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the formation of WDR5-containing histone-modifying complexes. ... | |
medium_hidden_intermediate_09163 | Zika virus downregulates a specific gene that is involved in the negative regulation of the ERK1 and ERK2 cascade. Experimental data for this gene in glioma stem cells (from study GSE114907) reports a log2 fold change of approximately -1.20 and an adjusted p-value of 0.0382. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09163","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the negative regulation of the ERK1 and ERK2 cascade. Experimen... | |
medium_hidden_intermediate_09164 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Aerobic respiration and respiratory electron transport. Evidence for this gene reports a log2 fold change of 1.877 and an adjusted p-value of 0.001916. Which disease is associated with this gene? | hydroxyacyl glutathione hydrolase deficiency | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09164","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Aerobic respiration and r... | |
medium_hidden_intermediate_09166 | Zika virus downregulates a specific gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for this gene in glioma stem cells reports a log2 fold change of approximately -2.036 and an adjusted p-value of 0.01184. Which molecular function is enabled by this gene? | heparin binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09166","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for this g... | |
medium_hidden_intermediate_09167 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with RHOB. Experimental data for this gene in a cardiomyocyte cell line (study GSE151879) reports a log2 fold change of approximately 1.20 and an adjusted p-value of approximately 0.0068. Which disease is associated with this g... | osteosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09167","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with RHOB. Experimental data fo... | |
medium_hidden_intermediate_09171 | Two genes are structurally linked from Pegivirus C via a downregulation relationship and subsequently to Naive B cells via an enrichment relationship. One of these genes exhibits a log2 fold change of -1.007 and an adjusted p-value of 0.002907 in peripheral blood mononuclear cells. Which disease is associated with this... | Ischemic stroke | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09171","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Pegivirus C via a downregulation relationship and subsequently to Naive B cells via a... | |
medium_hidden_intermediate_09172 | Human immunodeficiency virus 1 downregulates a gene that interacts with BRCA1. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -1.244 and an adjusted p-value of 0.002284. Which protein is encoded by this gene? | Kinesin-like protein KIFC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09172","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that interacts with BRCA1. In a study of macrophages (GSE108897), one su... | |
medium_hidden_intermediate_09176 | Two genes are upregulated by Influenza A virus and enriched in classical monocytes. One of these genes exhibits a log2 fold change of 1.677 and an adjusted p-value of 0.01147 in response to the virus. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09176","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Influenza A virus and enriched in classical monocytes. One of these genes exhibits a log2 fold ... | |
medium_hidden_intermediate_09177 | A gene is downregulated by Primate bocaparvovirus 1 and its product is located in the mitochondrion. Transcriptomic data for this gene in a specific study reports a log2 fold change of -2.100 and an adjusted p-value of 0.02976. Which protein is encoded by this gene? | Mitochondrial fission process protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09177","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and its product is located in the mitochondrion. Transcriptomic data for... | |
medium_hidden_intermediate_09182 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that subsequently bind to SF3B6. One such gene exhibited a log2 fold change of 1.712 and an adjusted p-value of 3.054e-10. Which protein is encoded by this specific gene? | U6 snRNA-associated Sm-like protein LSm5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09182","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_09183 | A gene is expressed in epithelial cells and its protein product is located in the Golgi apparatus. Evidence indicates that this protein localizes to the endoplasmic reticulum, Golgi, trans-Golgi network, endosomes, and plasma membrane, and that its cellular localization patterns depend on the presence of its transmembr... | GGA1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09183","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is expressed in epithelial cells and its protein product is located in the Golgi apparatus. Evidence indicates that t... | |
medium_hidden_intermediate_09184 | Pegivirus C is reported to downregulate a gene that is involved in replication fork processing. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.336 and an adjusted p-value of 0.01312. Which protein is encoded by this specific gene? | Histone-lysine N-methyltransferase SETMAR | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09184","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in replication fork processing. In a study of peripheral blo... | |
medium_hidden_intermediate_09186 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the antiviral innate immune response. Experimental data for this gene shows a log2 fold change of -1.160 and an adjusted p-value of 0.006861. Which disease is associated with this gene as a biomarker? | aneuploidy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09186","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the antiviral innate imm... | |
medium_hidden_intermediate_09190 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with PPP1R9B. Experimental data for this gene in choroid plexus epithelium shows a log2 fold change of -2.712 and an adjusted p-value of 1.463e-06. Which protein is encoded by this gene? | Sorting nexin-33 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09190","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with PPP1R9B. Experimental data fo... | |
medium_hidden_intermediate_09191 | Two distinct genes form interaction bridges between GSK3B and UBE2I. One of these intermediate genes is supported by evidence stating: 'Furthermore, co-immunoprecipitation analysis revealed a physical association between endogenous GSK3 beta and the protein encoded by this gene in HEK293 cells.' Which protein is encode... | Mitogen-activated protein kinase kinase kinase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09191","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct genes form interaction bridges between GSK3B and UBE2I. One of these intermediate genes is supported by evidenc... | |
medium_hidden_intermediate_09192 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with colon carcinoma. One of these genes exhibits a log2 fold change of 1.023 and an adjusted p-value of 0.007504 in a specific study. Which biological process is this specific gene involved in? | mRNA export from nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09192","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with colon carcinoma. ... | |
medium_hidden_intermediate_09193 | Human immunodeficiency virus 1 upregulates a gene that participates in the CDC42 GTPase cycle. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 1.692 and an adjusted p-value of 0.01557. Which disease is associated with this gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09193","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the CDC42 GTPase cycle. Evidence for this gene in mac... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.