qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_hidden_intermediate_09194 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables GTPase activity. Experimental data for this gene reports a log2 fold change of approximately 1.064 and an adjusted p-value of approximately 0.0009971. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09194","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables GTPase activity. Experimental dat... | |
medium_hidden_intermediate_09197 | Two genes are linked to Pegivirus C via downregulation and to thyroid tumor via biomarker association. One of these genes exhibits a log2 fold change of -2.212 and an adjusted p-value of 0.01088 in peripheral blood mononuclear cells. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09197","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Pegivirus C via downregulation and to thyroid tumor via biomarker association. One of these genes ex... | |
medium_hidden_intermediate_09199 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to colon carcinoma via an association relationship. One of these genes exhibits a log2 fold change of -1.307 and an adjusted p-value of 0.005415 in a specific study context. Which cell type is enriched for that spe... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09199","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to colon carcinoma... | |
medium_hidden_intermediate_09200 | Zika virus downregulates a specific gene, which in turn interacts with VAPB. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.85 and an adjusted p-value of 0.0225. Which biological process is this gene involved in? | mitochondrial fusion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09200","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with VAPB. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_09201 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes that participate in GPCR downstream signalling. One such gene exhibited a log2 fold change of approximately 7.95 and an adjusted p-value of 0.006166. Which protein is encoded by this specific gene? | C-C motif chemokine 4-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09201","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes that ... | |
medium_hidden_intermediate_09202 | Human immunodeficiency virus 1 upregulates a gene that enables sequence-specific double-stranded DNA binding. Evidence for this gene reports a log2 fold change of 1.039 and an adjusted p-value of 0.001467. Which cell type is this gene enriched in? | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09202","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables sequence-specific double-stranded DNA binding. Evidence for t... | |
medium_hidden_intermediate_09204 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of inflammatory response. Evidence for this gene in lung cells reports a log2 fold change of 3.193 and an adjusted p-value of 0.02456. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09204","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of infl... | |
medium_hidden_intermediate_09205 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that participate in GPCR ligand binding. One such gene exhibited a log2 fold change of 2.927 and an adjusted p-value of 5.188e-07. Which cellular component is the location of this specific gene p... | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09205","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_09206 | Human betaherpesvirus 5 is reported to upregulate a gene that is involved in the positive regulation of cell population proliferation. Experimental data for one such gene indicates a log2 fold change of approximately 1.012 and an adjusted p-value of 0.004026. Which protein is encoded by this specific gene? | Interleukin-11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09206","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is involved in the positive regulation of cell population prol... | |
medium_hidden_intermediate_09207 | Pancreatic neoplasms are localized to an anatomical structure that serves as a channel for bile. Evidence describes this structure as 'Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine.' Which anatomical entity does this structure develop from? | hepatic diverticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09207","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pancreatic neoplasms are localized to an anatomical structure that serves as a channel for bile. Evidence describes this str... | |
medium_hidden_intermediate_09208 | A gene is upregulated by Cardiovirus A and participates in the Immune System. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately 1.165 and an adjusted p-value of approximately 0.0387. Which disease is associated with this gene as a biomar... | pulmonary emphysema | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09208","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Cardiovirus A and participates in the Immune System. Experimental data for this gene in a cervical ... | |
medium_hidden_intermediate_09210 | Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of cytokine production. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 1.55 and an adjusted p-value of 0.0384. Which disease is associated with this gene as a biomarker... | ovarian neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09210","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of cytokine production. Eviden... | |
medium_hidden_intermediate_09211 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the type III interferon-mediated signaling pathway. Experimental data for this gene reports a log2 fold change of approximately 1.23 and an adjusted p-value of approximately 0.00052. Which disease is associated with this g... | hypersensitivity reaction disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09211","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the type III interferon-me... | |
medium_hidden_intermediate_09212 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to open-angle glaucoma via genomic alterations. One of these genes was reported in a study (GSE160351) involving monocytes, with a log2 fold change of approximately 1.002 and an adjusted p-value of 0.01543. Which protein ... | Sex hormone-binding globulin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09212","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to open-angle glaucoma vi... | |
medium_hidden_intermediate_09213 | Zaire ebolavirus downregulates a specific gene product that enables identical protein binding. In a study of retinal pigment epithelium cells (GSE100839), this entity exhibited a log2 fold change of -1.336 and an adjusted p-value of 0.03238. Which biological process is this entity involved in? | proteolysis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09213","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a specific gene product that enables identical protein binding. In a study of retinal pigment... | |
medium_hidden_intermediate_09214 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which is also associated with hyperlipidemia. This gene exhibited a log2 fold change of 1.636 and an adjusted p-value of 8.009e-05. Which protein is encoded by this gene? | Signal-transducing adaptor protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09214","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_09215 | Enterovirus A is reported to downregulate a gene that enables polypeptide N-acetylgalactosaminyltransferase activity. In a study of rhabdomyosarcoma cells (GSE103308), one such gene exhibited a log2 fold change of approximately -1.345 and an adjusted p-value of 0.02661. Which protein is encoded by this specific gene? | Polypeptide N-acetylgalactosaminyltransferase 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09215","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a gene that enables polypeptide N-acetylgalactosaminyltransferase activity. In a s... | |
medium_hidden_intermediate_09216 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and binds to CTNNA1. Experimental data for this gene in a cardiomyocyte cell line (study GSE162736) shows a log2 fold change of -1.085 and an adjusted p-value of 0.003871. Which disease is associated with this gene through genomic alterati... | multiple sclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09216","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and binds to CTNNA1. Experimental data for ... | |
medium_hidden_intermediate_09217 | Two genes are downregulated by Pegivirus C and interact with DYNLL1. One of these genes exhibits a log2 fold change of approximately -2.06 and an adjusted p-value of 0.0068 in peripheral blood mononuclear cells. Which cellular component is the gene with these specific expression statistics located in? | RNA polymerase II transcription regulator complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09217","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and interact with DYNLL1. One of these genes exhibits a log2 fold change of appro... | |
medium_hidden_intermediate_09219 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene, which in turn enables ATP binding. This gene exhibits a log2 fold change of approximately -1.008 and an adjusted p-value of 0.0004079. Which protein is encoded by this gene? | Inactive tyrosine-protein kinase PEAK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09219","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_09220 | Zika virus downregulates a gene that is involved in the positive regulation of transforming growth factor beta receptor signaling pathway. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.28 and an adjusted p-value of 0.033. Which protein is encoded by this ge... | TSC22 domain family protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09220","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the positive regulation of transforming growth factor beta receptor sign... | |
medium_hidden_intermediate_09222 | In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene involved in the cholesterol biosynthetic process. This specific gene exhibited a log2 fold change of 1.154 and an adjusted p-value of 0.002512. Which gene interacts with this upregulated entity? | SLC37A3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09222","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene... | |
medium_hidden_intermediate_09223 | Human immunodeficiency virus 1 is reported to downregulate a gene that is associated with benign neoplasm. In a study of macrophages (GSE108897), one such gene exhibits a log2 fold change of approximately -7.27 and an adjusted p-value of 0.01246. Which protein is encoded by this specific gene? | Neuronal pentraxin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09223","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 is reported to downregulate a gene that is associated with benign neoplasm. In a study of mac... | |
medium_hidden_intermediate_09225 | A gene is downregulated by Measles morbillivirus and located in the plasma membrane. Experimental data for this gene reports a log2 fold change of approximately -2.08 and an adjusted p-value of 0.0007534. Which disease is associated with this gene through genomic alterations? | polyarticular arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09225","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and located in the plasma membrane. Experimental data for this gene reports... | |
medium_hidden_intermediate_09226 | A gene is downregulated by Primate bocaparvovirus 1 and participates in SLC-mediated transport of amino acids. Evidence for this gene reports a log2 fold change of -1.012 and an adjusted p-value of 0.04684. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09226","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in SLC-mediated transport of amino acids. Evidence for ... | |
medium_hidden_intermediate_09227 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with mammary neoplasms in animals. One of these genes was reported in a study (GSE148697) involving lung cells, with a log2 fold change of approximately 1.01 and an adjusted p-value of 0.0115. Which disease is linked t... | myofibrillar myopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09227","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with mammary neoplasms... | |
medium_hidden_intermediate_09229 | Zika virus upregulates a specific gene that participates in Signaling by GPCR. Experimental data for this gene indicates a log2 fold change of 2.365 and an adjusted p-value of 0.001522. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09229","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene that participates in Signaling by GPCR. Experimental data for this gene indicates a l... | |
medium_hidden_intermediate_09230 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and participates in RHO GTPase Effectors. Evidence for this gene reports a log2 fold change of -1.587 and an adjusted p-value of 0.02286. Which protein is encoded by this gene? | Protein phosphatase 1 regulatory subunit 14A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09230","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and particip... | |
medium_hidden_intermediate_09231 | Rhinovirus A infection is associated with the upregulation of specific genes that are subsequently found in extracellular exosomes. One such gene exhibits a log2 fold change of approximately 1.025 and an adjusted p-value of 0.008591 in cytotoxic T-lymphocytes. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09231","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the upregulation of specific genes that are subsequently found in extracellular ex... | |
medium_hidden_intermediate_09234 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with retinal degeneration. One of these genes exhibits a log2 fold change of approximately 1.067 and an adjusted p-value of 0.02934 in lung cells. Which gene interacts with the gene identified by these expression stati... | FOXP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09234","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with retinal degenerat... | |
medium_hidden_intermediate_09235 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and participates in protein hydroxylation. This specific gene exhibits a log2 fold change of -1.181 and an adjusted p-value of 0.01444. Which protein is encoded by this gene? | Prolyl 3-hydroxylase OGFOD1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09235","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and part... | |
medium_hidden_intermediate_09236 | Two genes are each upregulated by Measles morbillivirus and associated with mammary neoplasms in animals. One of these genes was reported in a study (GSE117668) involving pleural mesothelioma cells, showing a log2 fold change of approximately 1.599 and an adjusted p-value of 0.0006732. Which protein does this specific ... | PDIA4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09236","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Measles morbillivirus and associated with mammary neoplasms in animals. One of these genes... | |
medium_hidden_intermediate_09237 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with TMEM43. Experimental data for this gene reports a log2 fold change of 1.174 and an adjusted p-value of 0.007155. Which protein is encoded by this gene? | GRAM domain-containing protein 2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09237","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with TMEM43. Experimental data ... | |
medium_hidden_intermediate_09238 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and onward to benign neoplasm of large intestine via a biomarker relationship. One of these genes is associated with a log2 fold change of 1.236 and an adjusted p-value of 0.002074 in the provid... | extracellular region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09238","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via an upregulation relationshi... | |
medium_hidden_intermediate_09239 | A gene is upregulated by Human immunodeficiency virus 1 and located in the focal adhesion. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of 1.407 and an adjusted p-value of 0.003861. Which disease is associated with this gene as a biomarker? | prostate carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09239","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and located in the focal adhesion. Evidence for this gene in macroph... | |
medium_hidden_intermediate_09240 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Unfolded Protein Response (UPR). Transcriptomic data for this gene shows a log2 fold change of approximately 1.91 and an adjusted p-value of approximately 0.021. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09240","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Unfolded Protein Resp... | |
medium_hidden_intermediate_09242 | Zika virus downregulates a specific gene, which in turn interacts with DOCK7. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.206 and an adjusted p-value of 0.0089. Which biological process is this gene involved in? | hippo signaling | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09242","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with DOCK7. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_09243 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAC1 GTPase cycle. One of these genes shows a log2 fold change of approximately 3.78 and an adjusted p-value of 0.0142 in a specific study. Which protein is encoded by this gene? | MAGUK p55 subfamily member 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09243","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAC1 GTPase cycle.... | |
medium_hidden_intermediate_09244 | Zika virus downregulates a specific gene, which in turn interacts with TNFAIP3. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.878 and an adjusted p-value of 0.01196. Which disease is associated with this gene? | chondrosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09244","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with TNFAIP3. Experimental data for this gene in glioma st... | |
medium_hidden_intermediate_09245 | Two genes are structurally linked from Cardiovirus A to clear cell renal carcinoma via a downregulation relationship followed by a biomarker association. One of these genes is reported in study GSE122967 (cervical adenocarcinoma cell line) with a log2 fold change of approximately -2.72 and an adjusted p-value of approx... | P2Y purinoceptor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09245","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Cardiovirus A to clear cell renal carcinoma via a downregulation relationship followe... | |
medium_hidden_intermediate_09247 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the retinoic acid biosynthesis pathway. Evidence for this gene reports a log2 fold change of 1.815 and an adjusted p-value of 0.01926. Which molecular function is enabled by this gene? | retinal dehydrogenase (NAD+) activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09247","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the retinoic acid biosynthesis... | |
medium_hidden_intermediate_09248 | A gene is downregulated by Measles morbillivirus and enables identical protein binding. Experimental data for this gene reports a log2 fold change of -1.095 and an adjusted p-value of 0.01682. Which cell type is this gene enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09248","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and enables identical protein binding. Experimental data for this gene repo... | |
medium_hidden_intermediate_09249 | Trophoblast cells express specific markers that enable protein binding. One such marker is identified in literature where human paxillin is reported as a binding partner of its tyrosine-phosphorylated cytoplasmic domain. Which protein is encoded by this marker gene? | Cell adhesion molecule CEACAM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09249","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Trophoblast cells express specific markers that enable protein binding. One such marker is identified in literature where hu... | |
medium_hidden_intermediate_09250 | A gene is downregulated by Hepacivirus C and enables identical protein binding. Transcriptomic data for this gene reports a log2 fold change of approximately -1.54 and an adjusted p-value of 0.0147. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09250","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Hepacivirus C and enables identical protein binding. Transcriptomic data for this gene reports a ... | |
medium_hidden_intermediate_09251 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that enables zinc ion binding. One such gene exhibited a log2 fold change of 3.213 and an adjusted p-value of 3.097e-09. Which protein is encoded by this specific gene? | Methionine-R-sulfoxide reductase B1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09251","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that en... | |
medium_hidden_intermediate_09253 | Two genes are structurally linked in a pathway where Human immunodeficiency virus 1 downregulates the gene, and the gene participates in Neutrophil degranulation. One of these genes has an associated expression profile in macrophages (from study GSE108897) showing a log2 fold change of approximately -2.63 and an adjust... | intervertebral disk degenerative disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09253","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked in a pathway where Human immunodeficiency virus 1 downregulates the gene, and the gene par... | |
medium_hidden_intermediate_09255 | Sarcoidosis is localized to an anatomical structure that develops from the respiratory primordium. Evidence indicates that this specific structure is the portion of the airway that attaches to the bronchi as it branches. What is the broader anatomical category to which this structure belongs? | respiratory tube | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09255","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Sarcoidosis is localized to an anatomical structure that develops from the respiratory primordium. Evidence indicates that t... | |
medium_hidden_intermediate_09257 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is downregulated by the virus and participates in protein localization. This gene exhibits a log2 fold change of -1.062 and an adjusted p-value of 0.0002271. Which protein is encoded by this gene? | Frataxin, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09257","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is... | |
medium_hidden_intermediate_09259 | Pegivirus C downregulates a gene that is involved in clathrin-coated vesicle cargo loading, AP-3-mediated. Evidence for this gene reports a log2 fold change of -1.646 and an adjusted p-value of 0.0002088. Which protein is encoded by this gene? | AP-3 complex subunit mu-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09259","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that is involved in clathrin-coated vesicle cargo loading, AP-3-mediated. Evidence for this... | |
medium_hidden_intermediate_09260 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Peroxisomal protein import. One such gene exhibits a log2 fold change of 1.821 and an adjusted p-value of 0.01083. Which protein is encoded by this specific gene? | Peroxisomal carnitine O-octanoyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09260","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Peroxisomal pr... | |
medium_hidden_intermediate_09261 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene involved in cell-cell signaling. This specific gene exhibited a log2 fold change of -1.386 and an adjusted p-value of 0.0009841. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09261","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_09263 | Rhinovirus A downregulates a specific gene that participates in the Immune System. Experimental data for this gene in cytotoxic T-lymphocytes (study GSE106475) shows a log2 fold change of -3.487 and an adjusted p-value of 0.0003782. Which biological process is this gene involved in? | response to virus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09263","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A downregulates a specific gene that participates in the Immune System. Experimental data for this gene in cytoto... | |
medium_hidden_intermediate_09264 | A gene is upregulated by Measles morbillivirus and participates in Dengue Virus-Host Interactions. Experimental evidence for this gene reports a log2 fold change of 1.794 and an adjusted p-value of 0.00285. Which protein is encoded by this gene? | Histone H2B type 1-C/E/F/G/I | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09264","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in Dengue Virus-Host Interactions. Experimental evidence for... | |
medium_hidden_intermediate_09265 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participates in Signaling by GPCR. Evidence for this gene reports a log2 fold change of approximately 1.83 and an adjusted p-value of 0.0246. Which protein is encoded by this gene? | Probable G-protein coupled receptor 132 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09265","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participate... | |
medium_hidden_intermediate_09268 | Pegivirus C downregulates a specific gene, which in turn interacts with HDAC3. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.17 and an adjusted p-value of 0.002284. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09268","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, which in turn interacts with HDAC3. Experimental data for this intermediate gene ... | |
medium_hidden_intermediate_09270 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Glycosphingolipid metabolism. One of these genes exhibits a log2 fold change of -1.380 and an adjusted p-value of 0.00259 in a specific study. Which protein is encoded by this gene? | Ceramide glucosyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09270","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Glycosphingolipid me... | |
medium_hidden_intermediate_09273 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the metabolism of vitamins and cofactors. Experimental data for this gene in a cardiomyocyte cell line (study GSE151879) reports a log2 fold change of approximately 1.014 and an adjusted p-value of 0.007003. Which biologi... | protein auto-ADP-ribosylation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09273","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the metabolism of vitamin... | |
medium_hidden_intermediate_09274 | Human immunodeficiency virus 1 downregulates a gene that participates in the regulation of cytoskeletal remodeling and cell spreading by IPP complex components. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.743 and an adjusted p-value of 0.04354. Which protein is encoded by this ge... | LIM and senescent cell antigen-like-containing domain protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09274","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in the regulation of cytoskeletal remodeling and cell ... | |
medium_hidden_intermediate_09276 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that enables NADH pyrophosphatase activity. One such gene exhibited a log2 fold change of 2.784 and an adjusted p-value of 2.874e-08. Which protein is encoded by this specific gene? | NAD-capped RNA hydrolase NUDT12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09276","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that en... | |
medium_hidden_intermediate_09277 | Hepacivirus C upregulates a gene that participates in the regulation of homotypic cell-cell adhesion. Experimental data for this gene shows a log2 fold change of 1.674 and an adjusted p-value of 0.008793. What molecular function is enabled by this gene? | sequence-specific double-stranded DNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09277","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the regulation of homotypic cell-cell adhesion. Experimental data for ... | |
medium_hidden_intermediate_09278 | Enterovirus A upregulates a specific gene that participates in the S Phase. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately 1.89 and an adjusted p-value of 0.00046. Which disease is associated with this gene as a biomarker? | colorectal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09278","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a specific gene that participates in the S Phase. Experimental data for this gene in rhabdomyosarc... | |
medium_hidden_intermediate_09279 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in cholesterol biosynthesis. Evidence for this gene reports a log2 fold change of approximately -1.074 and an adjusted p-value of 0.0001135. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09279","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in cholesterol biosynthesis. Ev... | |
medium_hidden_intermediate_09280 | Zika virus downregulates a specific gene, which in turn interacts with CDC42. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.915 and an adjusted p-value of 0.007385. Which disease is associated with genomic alterations in this gene? | pancreatic ductal adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09280","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with CDC42. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_09282 | Hepacivirus C upregulates a gene that participates in Stimuli-sensing channels. Evidence for one such gene reports a log2 fold change of 3.442 and an adjusted p-value of 0.0226. Which gene binds to the target of this specific gene? | SCNN1G | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09282","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in Stimuli-sensing channels. Evidence for one such gene reports a log2 fo... | |
medium_hidden_intermediate_09284 | Hepacivirus C is reported to upregulate a gene that is associated with non-small cell lung carcinoma. In a specific study (GSE12720), this gene exhibited a log2 fold change of 2.725 and an adjusted p-value of 1.471e-05. Which protein is encoded by this gene? | Cell adhesion molecule CEACAM6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09284","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is associated with non-small cell lung carcinoma. In a specific study (G... | |
medium_hidden_intermediate_09286 | Human alphaherpesvirus 1 upregulates a gene that participates in the mitotic cell cycle. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 2.818 and an adjusted p-value of 0.004921. Which disease is associated with this gene as a biomarker? | testicular cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09286","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in the mitotic cell cycle. Evidence for this gene in a monocyt... | |
medium_hidden_intermediate_09288 | Human betaherpesvirus 5 downregulates a gene that participates in Mitotic Prometaphase. Evidence for this gene reports a log2 fold change of -2.582 and an adjusted p-value of 0.01878. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09288","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that participates in Mitotic Prometaphase. Evidence for this gene reports a log... | |
medium_hidden_intermediate_09289 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate certain genes that participate in the M Phase. One such gene exhibited a log2 fold change of -2.132 and an adjusted p-value of 0.004534. Which protein is encoded by this specific gene? | Protein ELYS | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09289","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate certain genes that participate i... | |
medium_hidden_intermediate_09290 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and interacts with NACC1. This gene exhibits a log2 fold change of approximately 1.598 and an adjusted p-value of 3.726e-10. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09290","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_09293 | Two genes are structurally linked in a pathway where Influenza A virus downregulates the gene, which is subsequently associated with obesity disorder. One of these genes was reported in a study of bronchial epithelial cells (GSE147507) with a log2 fold change of -1.363 and an adjusted p-value of 0.0003945. Which protei... | Sodium-dependent neutral amino acid transporter B(0)AT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09293","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked in a pathway where Influenza A virus downregulates the gene, which is subsequently associa... | |
medium_hidden_intermediate_09294 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and its product enables cytoskeletal protein binding. This gene exhibits a log2 fold change of approximately 1.23 and an adjusted p-value of 1.17e-06. Which protein is encoded by this gene? | Dual specificity protein phosphatase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09294","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and its product ena... | |
medium_hidden_intermediate_09295 | Zika virus upregulates a gene that participates in post-translational protein modification. Experimental data from neural stem cells (study GSE129180) indicates that this gene has a log2 fold change of approximately 2.144 and an adjusted p-value of 0.03526. Which protein does this gene bind to? | FAM20C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09295","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in post-translational protein modification. Experimental data from neural st... | |
medium_hidden_intermediate_09297 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and located in extracellular exosomes. Evidence for this gene reports a log2 fold change of 1.763 and an adjusted p-value of 0.04969. Which protein does this gene product bind to? | TBC1D17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09297","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and located in ... | |
medium_hidden_intermediate_09299 | Severe acute respiratory syndrome-related coronavirus upregulates multiple genes that enable RNA nuclease activity. One such gene exhibits a log2 fold change of 1.845 and an adjusted p-value of 9.34e-07 in a non-small cell lung adenocarcinoma cell line. Which protein is encoded by this specific gene? | Non-secretory ribonuclease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09299","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates multiple genes that enable RNA nuclease activity. One such... | |
medium_hidden_intermediate_09300 | Zika virus downregulates a gene that is involved in the regulation of cilium assembly. Evidence for this specific gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.604 and an adjusted p-value of 0.01157. Which cellular component is this gene located in? | early endosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09300","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the regulation of cilium assembly. Evidence for this specific gene in gl... | |
medium_hidden_intermediate_09301 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene involved in the negative regulation of T cell activation. This gene exhibited a log2 fold change of 9.542 and an adjusted p-value of 0.0001417. Which protein is encoded by this gene? | Lymphocyte activation gene 3 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09301","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_09302 | Zika virus downregulates a gene that participates in the RHOC GTPase cycle. In glioma stem cells, one such gene exhibits a log2 fold change of -2.053 and an adjusted p-value of 0.03425. Which protein is encoded by this gene? | Disheveled-associated activator of morphogenesis 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09302","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the RHOC GTPase cycle. In glioma stem cells, one such gene exhibits a l... | |
medium_hidden_intermediate_09304 | Human immunodeficiency virus 1 downregulates a gene that is involved in the regulation of protein stability. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.44 and an adjusted p-value of approximately 0.027. Which protein does this gene interact with? | CD40 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09304","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the regulation of protein stability. In a study of m... | |
medium_hidden_intermediate_09305 | Human immunodeficiency virus 1 downregulates a gene that participates in deubiquitination. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -1.191 and an adjusted p-value of 0.04195. Which protein is encoded by this gene? | Actin-related protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09305","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in deubiquitination. In a study of macrophages (GSE108... | |
medium_hidden_intermediate_09306 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Glycerophospholipid biosynthesis. One of these genes exhibits a log2 fold change of -1.098 and an adjusted p-value of 0.03775. Which cellular component is the location of this specific gene? | extracellular region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09306","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Glycerophospholipid ... | |
medium_hidden_intermediate_09307 | Two genes are structurally linked from Human immunodeficiency virus 1 via an upregulation relationship and onward to inborn error of immunity via a biomarker relationship. One of these genes is associated with a log2 fold change of 3.157 and an adjusted p-value of 1.812e-06 in a specific study context. Which protein is... | Coxsackievirus and adenovirus receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09307","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human immunodeficiency virus 1 via an upregulation relationship and onward to inborn ... | |
medium_hidden_intermediate_09309 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is upregulated and involved in the long-chain fatty acid metabolic process. Evidence for this gene reports a log2 fold change of 1.826 and an adjusted p-value of 0.03376. Which protein is encoded by this gene? | Long-chain-fatty-acid--CoA ligase ACSBG1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09309","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is upregulated and involved in the lon... | |
medium_hidden_intermediate_09310 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene was found to be downregulated by the virus and involved in DNA damage checkpoint signaling. This gene exhibited a log2 fold change of -1.405 and an adjusted p-value of 0.0002257. Which protein is encoded by thi... | Guanine nucleotide-binding protein subunit beta-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09310","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene was found to b... | |
medium_hidden_intermediate_09311 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables enzyme binding. Evidence for this gene reports a log2 fold change of -2.032 and an adjusted p-value of 0.002119. Which protein is encoded by this gene? | Golgin subfamily A member 7B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09311","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables enzyme binding. Evidence for this ge... | |
medium_hidden_intermediate_09312 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene involved in glycosaminoglycan metabolism. This gene exhibited a log2 fold change of approximately -1.55 and an adjusted p-value of approximately 0.019. Which protein is encoded by this downreg... | Uronyl 2-sulfotransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09312","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_09313 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a specific gene that participates in the innate immune system. The expression data for this gene shows a log2 fold change of -1.087 and an adjusted p-value of 0.01414. Which protein is encoded by this gene? | Coactosin-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09313","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a specific gene that par... | |
medium_hidden_intermediate_09314 | Enterovirus A is reported to downregulate a specific gene that is involved in signal transduction. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) show a log2 fold change of approximately -1.47 and an adjusted p-value of approximately 0.0052. In which cell type is this gene reported to be en... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09314","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene that is involved in signal transduction. Experimental data for thi... | |
medium_hidden_intermediate_09315 | Zika virus downregulates a gene that interacts with CASK. Experimental data for this gene in glioma stem cells (study GSE114907) shows a log2 fold change of -1.630 and an adjusted p-value of 0.01926. Which protein is encoded by this gene? | Testis-specific Y-encoded-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09315","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with CASK. Experimental data for this gene in glioma stem cells (study GSE114... | |
medium_hidden_intermediate_09316 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is upregulated by the virus and interacts with NPM1. This gene exhibits a log2 fold change of 1.914 and an adjusted p-value of 0.0001443. Which protein is encoded by this gene? | Deoxynucleotidyltransferase terminal-interacting protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09316","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is upregulated by the virus and interacts ... | |
medium_hidden_intermediate_09318 | IFNL1 is involved in a biological process that is a subclass of negative regulation of immune response. Evidence indicates that IFN-lambda1 diminishes the change in cell-surface phenotype accompanying the differentiation of central memory T cells into effector memory T cells. Which biological process, connected to the ... | memory T cell differentiation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09318","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"IFNL1 is involved in a biological process that is a subclass of negative regulation of immune response. Evidence indicates t... | |
medium_hidden_intermediate_09319 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Membrane Trafficking. Experimental evidence for this gene shows a log2 fold change of approximately -1.014 and an adjusted p-value of 0.002318. Which biological process is this gene involved in? | protein N-linked glycosylation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09319","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Membrane Trafficking. E... | |
medium_hidden_intermediate_09324 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Drug ADME. One of these genes shows a log2 fold change of -4.638 and an adjusted p-value of 0.04857 in a specific study. Which protein is encoded by this gene? | Solute carrier organic anion transporter family member 1A2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09324","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Drug ADME. One of th... | |
medium_hidden_intermediate_09326 | Penile neoplasm is localized to an organ. Evidence concerning one such entity reports: 'The organ covering the body that consists of the dermis and epidermis.' Which anatomy is connected to that entity through the 'develops from' relation? | embryonic skin basal layer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09326","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Penile neoplasm is localized to an organ. Evidence concerning one such entity reports: 'The organ covering the body that con... | |
medium_hidden_intermediate_09327 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that binds to GNG2. Experimental data for this gene reports a log2 fold change of 2.585 and an adjusted p-value of 0.009655. Which protein is encoded by this gene? | C-C motif chemokine 26 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09327","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that binds to GNG2. Experimental data for this gene... | |
medium_hidden_intermediate_09328 | Two distinct drugs serve as intermediates in a pathway connecting Everolimus to Gilteritinib via drug-drug interactions. One of these intermediates is supported by evidence stating that its combination with Everolimus yields benefits including improved endothelial and smooth muscle marker expression, reduced apoptosis,... | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09328","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs serve as intermediates in a pathway connecting Everolimus to Gilteritinib via drug-drug interactions. One... | |
medium_hidden_intermediate_09330 | Zika virus downregulates a specific gene, which in turn interacts with YWHAE. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.93 and an adjusted p-value of approximately 0.0067. Which disease is associated with this gene? | intellectual developmental disorder with autistic features and language delay, with or without seizures | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09330","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with YWHAE. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_09331 | Human immunodeficiency virus 1 upregulates multiple genes that are located in clathrin-coated vesicles. One such gene exhibits a log2 fold change of 1.110 and an adjusted p-value of 8.968e-05 in macrophages. Which protein is encoded by this specific gene? | MAL-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09331","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates multiple genes that are located in clathrin-coated vesicles. One such gene exhibi... | |
medium_hidden_intermediate_09334 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables electron transfer activity. Experimental data for this gene in bronchial epithelial cells shows a log2 fold change of approximately 4.40 and an adjusted p-value of 0.0028. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09334","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables electron transfer activity. Exper... | |
medium_hidden_intermediate_09336 | IL12RB1 interacts with multiple proteins that possess protein binding activity. One such interacting partner is the subject of a study reporting: 'Here we present the crystal structure along with a mutational and biophysical analysis of the IL-13/IL-13Ralpha2 complex.' Which protein is encoded by the gene corresponding... | Interleukin-13 receptor subunit alpha-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09336","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"IL12RB1 interacts with multiple proteins that possess protein binding activity. One such interacting partner is the subject ... | |
medium_hidden_intermediate_09338 | Human immunodeficiency virus 1 downregulates multiple genes that are located in the extracellular space. One such gene exhibits a log2 fold change of -3.845 and an adjusted p-value of 0.01053 in macrophages (study GSE108897). Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09338","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates multiple genes that are located in the extracellular space. One such gene exhib... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.