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medium_hidden_intermediate_09339 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lung carcinoma. One of these genes exhibits a log2 fold change of 1.149 and an adjusted p-value of 0.02793 in lung tissue. Which cellular component is the location of this specific gene? | extracellular region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09339","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lung carcinoma. O... | |
medium_hidden_intermediate_09341 | Two genes are linked to Enterovirus A via downregulation and to schizophrenia via biomarker association. One of these genes exhibits a log2 fold change of -2.095 and an adjusted p-value of 0.005938 in rhabdomyosarcoma cells (study GSE103308). Which gene is this, and what protein does it bind to? | ADGRE5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09341","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Enterovirus A via downregulation and to schizophrenia via biomarker association. One of these genes ... | |
medium_hidden_intermediate_09342 | Zika virus downregulates a gene that participates in chromatin organization. Evidence for this gene shows a log2 fold change of -3.052 and an adjusted p-value of 0.01569. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09342","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in chromatin organization. Evidence for this gene shows a log2 fold change... | |
medium_hidden_intermediate_09343 | In a study of peripheral blood mononuclear cells (GSE119117), a specific gene is downregulated by Hepacivirus C and its product binds to CRHR1. This gene exhibits a log2 fold change of approximately -3.43 and an adjusted p-value of 0.0224. Which protein is encoded by this gene? | Urocortin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09343","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE119117), a specific gene is downregulated by Hepacivirus C and its prod... | |
medium_hidden_intermediate_09344 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in the metabolism of carbohydrates and carbohydrate derivatives. This gene exhibits a log2 fold change of 4.863 and an adjusted p-value of 0.0001066. Which biological process is this gene involved i... | lactosylceramide biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09344","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in... | |
medium_hidden_intermediate_09346 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and binds to NGF. This specific gene exhibits a log2 fold change of 4.680 and an adjusted p-value of 0.00936. Which protein is encoded by this gene? | Protein BEX1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09346","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and binds to NGF. This specif... | |
medium_hidden_intermediate_09347 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with invasive breast carcinoma. One of these genes exhibits a log2 fold change of 1.692 and an adjusted p-value of 1.144e-05 in a specific study. Which protein is encoded by this gene? | Connector enhancer of kinase suppressor of ras 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09347","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with invasive breast c... | |
medium_hidden_intermediate_09348 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables hydrogen peroxide channel activity. Evidence for one such gene reports a log2 fold change of 1.065 and an adjusted p-value of 0.009649. Which protein is encoded by that gene? | Aquaporin-11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09348","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables hydrogen peroxide channel activity. Ev... | |
medium_hidden_intermediate_09349 | NEDD4 interacts with a protein that enables protein binding. Experimental evidence indicates that this protein binds to Nedd4-1 and that its increased expression significantly reduces Itch expression. Which protein is encoded by the gene corresponding to this entity? | NEDD4 family-interacting protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09349","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"NEDD4 interacts with a protein that enables protein binding. Experimental evidence indicates that this protein binds to Nedd... | |
medium_hidden_intermediate_09351 | Hepacivirus C is reported to downregulate a gene that participates in G alpha (i) signalling events. Experimental data for this gene shows a log2 fold change of approximately -2.22 and an adjusted p-value of approximately 0.002. Which protein is encoded by this gene? | Regulator of G-protein signaling 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09351","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that participates in G alpha (i) signalling events. Experimental data for t... | |
medium_hidden_intermediate_09352 | Human alphaherpesvirus 3 upregulates a gene that participates in the Immune System. Evidence for one such gene reports a log2 fold change of 1.189 and an adjusted p-value of 3.406e-05. Which protein is encoded by that gene? | Cytokine receptor-like factor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09352","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that participates in the Immune System. Evidence for one such gene reports a log... | |
medium_hidden_intermediate_09353 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with amyloidosis. One of these genes exhibits a log2 fold change of -1.344 and an adjusted p-value of 0.007978 in a specific study. Which protein is encoded by this gene? | Class E basic helix-loop-helix protein 23 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09353","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with amyloidosis. On... | |
medium_hidden_intermediate_09354 | Two genes are structurally linked to Cardiovirus A via a downregulation relationship and to squamous cell carcinoma via an association relationship. One of these genes has a reported log2 fold change of -1.561 and an adjusted p-value of 0.01042 in a specific study. Which cellular component is the location of this speci... | centrosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09354","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a downregulation relationship and to squamous cell carcinoma via an a... | |
medium_hidden_intermediate_09355 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ATP binding. Experimental data for this gene reports a log2 fold change of 5.441 and an adjusted p-value of 0.04335. Which protein is encoded by this gene? | Death-associated protein kinase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09355","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ATP binding. Experimental data fo... | |
medium_hidden_intermediate_09356 | Hepacivirus C upregulates a gene that is involved in mitotic cytokinesis. Evidence for one such gene reports a log2 fold change of 1.083 and an adjusted p-value of 0.0001447. Which protein is encoded by that gene? | Ubiquitin carboxyl-terminal hydrolase 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09356","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in mitotic cytokinesis. Evidence for one such gene reports a log2 fold cha... | |
medium_hidden_intermediate_09357 | In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that enables lipid binding. This specific gene exhibited a log2 fold change of 1.314 and an adjusted p-value of 0.01199. Which protein is encoded by this gene? | Fatty acid-binding protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09357","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene... | |
medium_hidden_intermediate_09358 | FBXW11 interacts with a protein that is located in the nucleus. Evidence indicates that phosphorylation of this protein by Akt causes its nuclear translocation. Which cell type is this protein enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09358","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"FBXW11 interacts with a protein that is located in the nucleus. Evidence indicates that phosphorylation of this protein by A... | |
medium_hidden_intermediate_09359 | Cardiovirus A is reported to downregulate a gene that participates in the mitotic cell cycle. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibited a log2 fold change of -1.080 and an adjusted p-value of 0.01709. Which protein is encoded by this specific gene? | Protein lin-9 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09359","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A is reported to downregulate a gene that participates in the mitotic cell cycle. In a study of cervical adenoca... | |
medium_hidden_intermediate_09362 | Cardiovirus A downregulates a specific gene that participates in RNA metabolism. In a study of cervical adenocarcinoma cell lines (GSE122967), this gene exhibited a log2 fold change of approximately -1.118 and an adjusted p-value of 0.02758. Which protein does this gene product bind to? | TRMT112 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09362","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a specific gene that participates in RNA metabolism. In a study of cervical adenocarcinoma cell ... | |
medium_hidden_intermediate_09368 | Hepacivirus C downregulates a gene that enables sequence-specific DNA binding. Evidence for one such gene reports a log2 fold change of -1.282 and an adjusted p-value of 9.787e-05. Which disease is associated with that gene? | amyloidosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09368","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that enables sequence-specific DNA binding. Evidence for one such gene reports a log2 fol... | |
medium_hidden_intermediate_09371 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Cilium Assembly. One of these genes was reported in a study with a log2 fold change of approximately 1.26 and an adjusted p-value of approximately 0.007. Which protein is encoded by this specific gene? | Kinesin-like protein KIF17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09371","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Cilium Assembly. One o... | |
medium_hidden_intermediate_09373 | Zika virus downregulates a gene that participates in the metabolism of steroids. Evidence for this gene in glioma stem cells reports a log2 fold change of -1.957 and an adjusted p-value of 0.007403. Which disease is associated with this gene as a biomarker? | endometriosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09373","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the metabolism of steroids. Evidence for this gene in glioma stem cells... | |
medium_hidden_intermediate_09374 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a specific gene that participates in signal transduction. This gene exhibited a log2 fold change of approximately -1.27 and an adjusted p-value of 0.0115. Which protein is encoded by this gene? | Urotensin-2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09374","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a specific gene that par... | |
medium_hidden_intermediate_09376 | In a study of choroid plexus epithelium (GSE157852), a gene upregulated by Severe acute respiratory syndrome-related coronavirus and involved in the regulation of the pyruvate dehydrogenase (PDH) complex showed a log2 fold change of 1.250 and an adjusted p-value of 0.0003106. Which disease is associated with this speci... | proteinuria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09376","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), a gene upregulated by Severe acute respiratory syndrome-related coronav... | |
medium_hidden_intermediate_09378 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the focal adhesion. Evidence for one such gene reports a log2 fold change of -1.002 and an adjusted p-value of 0.0007442. Which protein is encoded by that gene? | Cysteine and glycine-rich protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09378","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the focal adhesion. Evidence f... | |
medium_hidden_intermediate_09379 | PTK2 interacts with a gene that participates in the Adaptive Immune System. Evidence indicates that this gene's protein product physically interacts with phosphorylated FAK in HCC cells. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09379","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PTK2 interacts with a gene that participates in the Adaptive Immune System. Evidence indicates that this gene's protein prod... | |
medium_hidden_intermediate_09380 | Hepacivirus C is reported to upregulate a gene that is involved in the negative regulation of transcription by RNA polymerase II. Experimental evidence for one such gene shows a log2 fold change of approximately 1.62 and an adjusted p-value of 0.001885. Which protein is encoded by this specific gene? | Nuclear autoantigen Sp-100 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09380","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is involved in the negative regulation of transcription by RNA polymeras... | |
medium_hidden_intermediate_09381 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in protein K48-linked ubiquitination. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -2.503 and an adjusted p-value of 0.001952. Which disease is associated with this gene as ... | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09381","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in protein K48-linked ubiquitination... | |
medium_hidden_intermediate_09383 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Rab regulation of trafficking. Evidence for one such gene reports a log2 fold change of 3.434 and an adjusted p-value of 0.01684. Which protein is encoded by that gene? | ALS2 C-terminal-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09383","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Rab regulation of trafficking.... | |
medium_hidden_intermediate_09384 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene product is upregulated by the virus and localized to the centriole. Evidence for this entity reports a log2 fold change of 1.165 and an adjusted p-value of 4.483e-09. Which protein is encoded by the gene correspondin... | Nuclear protein MDM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09384","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene product is upregulat... | |
medium_hidden_intermediate_09385 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the positive regulation of autophagosome assembly. Evidence for this specific gene reports a log2 fold change of -1.126 and an adjusted p-value of 6.284e-17. Which protein is encoded by this gene? | Sorting nexin-30 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09385","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the positive regulation of au... | |
medium_hidden_intermediate_09386 | Human immunodeficiency virus 1 upregulates a gene that participates in Cellular Senescence. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of 1.099 and an adjusted p-value of 0.02284. Which protein is encoded by this gene? | Histone H1.3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09386","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in Cellular Senescence. Evidence for this gene in macrop... | |
medium_hidden_intermediate_09387 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the Toll Like Receptor 4 (TLR4) Cascade. One such gene exhibits a log2 fold change of 1.055 and an adjusted p-value of 0.003416. Which protein is encoded by this specific gene? | Dynamin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09387","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the Toll Like ... | |
medium_hidden_intermediate_09388 | Zika virus downregulates a gene that is involved in signal transduction. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.199 and an adjusted p-value of 0.03529. Which protein is encoded by this specific gene? | GTP-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09388","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in signal transduction. In a study of glioma stem cells (GSE114907), one su... | |
medium_hidden_intermediate_09389 | Two genes are known to be upregulated by Vaccinia virus and serve as biomarkers for urinary bladder cancer. One of these genes exhibits a log2 fold change of approximately 2.73 and an adjusted p-value of approximately 0.00025 in cervical adenocarcinoma cell lines (study GSE11238). Which cell type is enriched for this s... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09389","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are known to be upregulated by Vaccinia virus and serve as biomarkers for urinary bladder cancer. One of these gen... | |
medium_hidden_intermediate_09390 | Pegivirus C is reported to downregulate a gene that enables protein homodimerization activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -2.174 and an adjusted p-value of 0.002047. Which gene interacts with the gene identified by these statistical values... | S100P | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09390","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables protein homodimerization activity. In a study of peripheral bloo... | |
medium_hidden_intermediate_09391 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables DNA-binding transcription factor binding. Evidence for this gene reports a log2 fold change of 2.318 and an adjusted p-value of 0.02371. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09391","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables DNA-binding transcription factor ... | |
medium_hidden_intermediate_09392 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with leukemia. One of these genes exhibits a log2 fold change of approximately 1.37 and an adjusted p-value of approximately 0.025 in a specific study. Which disease is linked to this specific gene via a biomarker rela... | Crohn disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09392","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with leukemia. One of ... | |
medium_hidden_intermediate_09393 | GNG2 binds to a specific G protein-coupled receptor that is involved in the adenylate cyclase-activating G protein-coupled receptor signaling pathway. Experimental evidence indicates that at pH 7.4, cells transfected with this receptor exhibit lower epidermal growth factor-induced extracellular signal-regulated kinase ... | G protein-coupled receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09393","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GNG2 binds to a specific G protein-coupled receptor that is involved in the adenylate cyclase-activating G protein-coupled r... | |
medium_hidden_intermediate_09394 | A gene is upregulated by Vaccinia virus and interacts with CDC42. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 1.093 and an adjusted p-value of approximately 0.000356. Which disease is associated with this gene? | pancreatic cancer, susceptibility to, 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09394","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and interacts with CDC42. Experimental data for this gene in a cervical adenocarcino... | |
medium_hidden_intermediate_09396 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a histone variant that participates in the methylation of histone arginines by RMTs. One such upregulated entity exhibits a log2 fold change of 2.494 and an adjusted p-value of 0.0005254. Which gene interacts with this specific upre... | TRIM24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09396","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a histone variant that participates ... | |
medium_hidden_intermediate_09397 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and participating in RNA Polymerase III abortive and retractive initiation. One of these genes exhibits a log2 fold change of approximately 1.48 and an adjusted p-value of 0.004. Which protein is encoded by this sp... | Transcription factor IIIB 50 kDa subunit | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09397","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and participating ... | |
medium_hidden_intermediate_09398 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which is located in the site of DNA damage. This gene exhibited a log2 fold change of -1.077 and an adjusted p-value of 0.004665. Which protein is encoded by this gene? | Aurora kinase A- and ninein-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09398","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_09399 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in the mitotic cell cycle. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this gene has a log2 fold change of -1.011 and an adjusted p-value of 0.003455. What is the name of the protein enco... | cAMP-regulated phosphoprotein 19 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09399","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in the mitotic cell cycle. Transcriptomi... | |
medium_hidden_intermediate_09400 | Human immunodeficiency virus 1 upregulates a gene that is located in the Golgi apparatus. Evidence for this gene reports a log2 fold change of 1.353 and an adjusted p-value of 0.01765. Which protein is encoded by this gene? | Beta-secretase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09400","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the Golgi apparatus. Evidence for this gene reports a l... | |
medium_hidden_intermediate_09401 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and onward to hyperinsulinism via an association relationship. One of these genes is reported in a study (GSE153684) with a log2 fold change of approximately -1.039 and an adjusted p-value of 1... | Prostaglandin G/H synthase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09401","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationsh... | |
medium_hidden_intermediate_09402 | Pegivirus C is reported to downregulate a gene that is involved in the regulation of cell migration. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this specific gene has a log2 fold change of approximately -1.53 and an adjusted p-value of approximately 0.00056. Which pr... | ABI gene family member 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09402","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the regulation of cell migration. Experimental data from ... | |
medium_hidden_intermediate_09404 | A gene is upregulated by Primate bocaparvovirus 1 and is enriched in neutrophils. Experimental evidence for this gene reports a log2 fold change of approximately 4.70 and an adjusted p-value of 0.04546. Which disease is associated with this gene? | mammary neoplasms, animal | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09404","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is enriched in neutrophils. Experimental evidence for this gene report... | |
medium_hidden_intermediate_09405 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lung carcinoma. One of these genes exhibits a log2 fold change of 2.037 and an adjusted p-value of 0.01288 in a specific study. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09405","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lung carcinoma. O... | |
medium_hidden_intermediate_09408 | Pegivirus C is reported to downregulate a specific gene, the product of which binds to RPS18. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of approximately -1.086 and an adjusted p-value of 0.0374. Which protein is encoded by this gene? | Eukaryotic translation initiation factor 3 subunit C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09408","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, the product of which binds to RPS18. In a study of peripheral blood... | |
medium_hidden_intermediate_09410 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable FAD binding. One of these genes shows a log2 fold change of 1.982 and an adjusted p-value of 0.0002253 in a specific cell type. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09410","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable FAD binding. One of these... | |
medium_hidden_intermediate_09411 | CSNK2A1 interacts with a specific protein that enables protein binding. Evidence indicates this protein is a newly identified binding partner of the α-subunit of CK2. Which disease is associated with this protein? | rheumatoid arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09411","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CSNK2A1 interacts with a specific protein that enables protein binding. Evidence indicates this protein is a newly identifie... | |
medium_hidden_intermediate_09413 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its expression is enriched in natural killer cells. Evidence for this gene reports a log2 fold change of 1.266 and an adjusted p-value of 0.0001103. Which protein is encoded by this gene? | Atypical chemokine receptor 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09413","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its expression is enriched in nat... | |
medium_hidden_intermediate_09414 | In a study of cervical adenocarcinoma cells (GSE11238), a gene is downregulated by Vaccinia virus and located in the mitochondrion. This gene exhibits a log2 fold change of approximately -1.148 and an adjusted p-value of 0.0043. Which protein is encoded by this gene? | Mitoguardin 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09414","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), a gene is downregulated by Vaccinia virus and located in the mitocho... | |
medium_hidden_intermediate_09415 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with colon carcinoma. One of these genes exhibits a log2 fold change of approximately 3.84 and an adjusted p-value of 0.0287 in bronchial epithelial cells. Which disease is linked to this specific gene through genomic ... | myelodysplastic syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09415","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with colon carcinoma. ... | |
medium_hidden_intermediate_09417 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in the regulation of pyruvate metabolism was found to have a log2 fold change of 1.223 and an adjusted p-value of 2.192e-05. Which protein does this specific gene product bind to? | WDR26 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09417","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in the regula... | |
medium_hidden_intermediate_09418 | Human betaherpesvirus 5 is linked to Co-inhibition by PD-1 via an intermediate entity that is upregulated by the virus and participates in the co-inhibition process. One such intermediate entity is reported in a study of foreskin fibroblast cell lines (GSE111036) with a log2 fold change of 3.152 and an adjusted p-value... | Histone H3.2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09418","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to Co-inhibition by PD-1 via an intermediate entity that is upregulated by the virus and p... | |
medium_hidden_intermediate_09420 | A gene serves as a marker for astrocytes and is also enriched in neutrophils. Evidence for this gene includes a mean expression of 532.27 TPM, a z-score of 2.30, and a fold enrichment of 3.39. Which disease is associated with this gene? | pancreatic neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09420","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for astrocytes and is also enriched in neutrophils. Evidence for this gene includes a mean express... | |
medium_hidden_intermediate_09421 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in intracellular iron ion homeostasis was found to have a log2 fold change of 2.742 and an adjusted p-value of 0.0008997. Which disease is associated with this specific gene? | Deficiency of ferroxidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09421","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in intracellu... | |
medium_hidden_intermediate_09422 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with NPM1. This gene exhibited a log2 fold change of approximately -1.725 and an adjusted p-value of 0.03129. Which protein is encoded by this gene? | Histone H1.3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09422","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_09423 | Zika virus downregulates a gene involved in cytoplasmic microtubule organization. In glioma stem cells (study GSE114907), one such gene exhibits a log2 fold change of approximately -2.27 and an adjusted p-value of 0.0194. Which protein is encoded by this specific gene? | SLAIN motif-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09423","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene involved in cytoplasmic microtubule organization. In glioma stem cells (study GSE114907), on... | |
medium_hidden_intermediate_09427 | Ureteral neoplasms are localized to an anatomical structure that serves as a channel for urine. Evidence describes this structure as having a funnel-shaped proximal portion formed by the convergence of the major calices. Which anatomical structure does this entity channel into? | ureter | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09427","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Ureteral neoplasms are localized to an anatomical structure that serves as a channel for urine. Evidence describes this stru... | |
medium_hidden_intermediate_09428 | Human immunodeficiency virus 1 downregulates a gene that is involved in the positive regulation of transcription by RNA polymerase II. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately -4.29 and an adjusted p-value of approximately 0.033. Which cellular component is thi... | transcription regulator complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09428","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the positive regulation of transcription by RNA poly... | |
medium_hidden_intermediate_09430 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of G1/S transition of the mitotic cell cycle. Evidence for one such gene reports a log2 fold change of 1.039 and an adjusted p-value of 0.006344. Which protein is encoded by that gene? | Protein Jade-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09430","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of G1/S... | |
medium_hidden_intermediate_09432 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and participating in Oncogenic MAPK signaling. One of these genes exhibits a log2 fold change of approximately 2.88 and an adjusted p-value of 0.0045. What is the protein encoded by this specific gene? | Lysine-specific demethylase 7A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09432","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and participating ... | |
medium_hidden_intermediate_09433 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to adult glioblastoma as biomarkers. One of these genes was reported in a study with a log2 fold change of 2.759 and an adjusted p-value of 0.0008903. Which protein is encoded by this specific gene? | Insulin-like growth factor-binding protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09433","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to adult glioblastoma as ... | |
medium_hidden_intermediate_09434 | HIF1A interacts with a protein that is enriched in plasmacytoid dendritic cells. Evidence indicates that the protein encoded by the gene interacting with HIF1A is enriched in plasmacytoid dendritic cells. Which protein is encoded by the gene connected to HIF1A via the 'interacts_with' relationship? | Transcriptional corepressor CBFA2T3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09434","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"HIF1A interacts with a protein that is enriched in plasmacytoid dendritic cells. Evidence indicates that the protein encoded... | |
medium_hidden_intermediate_09435 | A gene is upregulated by Hepacivirus C and enriched in classical monocytes. Evidence for this gene reports a log2 fold change of approximately 1.99 and an adjusted p-value of approximately 0.0378. Which disease is associated with this gene as a biomarker? | adrenal gland pheochromocytoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09435","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and enriched in classical monocytes. Evidence for this gene reports a log2 fold chang... | |
medium_hidden_intermediate_09436 | A gene is downregulated by Human gammaherpesvirus 8 and is enriched in eosinophils. Evidence for this gene in a non-Hodgkin lymphoma cell line reports a log2 fold change of approximately -1.365 and an adjusted p-value of 0.02754. Which disease is associated with this gene as a biomarker? | leiomyoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09436","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and is enriched in eosinophils. Evidence for this gene in a non-Hodgkin ... | |
medium_hidden_intermediate_09437 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn enables DNA binding. This gene exhibits a log2 fold change of -1.355 and an adjusted p-value of 0.01264. Which biological process is this gene involved in? | cellular response to calcium ion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09437","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_09438 | Zika virus infection has been shown to downregulate multiple genes involved in protein N-linked glycosylation. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.485 and an adjusted p-value of 0.04656. Which protein is encoded by this specific gene? | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09438","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection has been shown to downregulate multiple genes involved in protein N-linked glycosylation. In a study of... | |
medium_hidden_intermediate_09440 | A gene serves as a marker for oogenesis phase fetal germ cells and is enriched in naive B cells. Evidence for one such gene reports a mean expression of 3.69 TPM, a z-score of 1.64, and a fold enrichment of 2.79. Which disease is associated with this gene as a biomarker? | adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09440","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for oogenesis phase fetal germ cells and is enriched in naive B cells. Evidence for one such gene ... | |
medium_hidden_intermediate_09441 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of a specific gene that physically interacts with MT-CO1. This gene exhibits a log2 fold change of 1.356 and an adjusted p-value of 6.36e-14. Which biological process is this gene involved in? | mitochondrial respirasome assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09441","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of a specific gen... | |
medium_hidden_intermediate_09444 | Human immunodeficiency virus 1 downregulates a specific gene that participates in cellular responses to stimuli. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -3.844 and an adjusted p-value of 0.004912. Which disease is associated with this gene as a biomarker? | Charcot-Marie-Tooth disease type 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09444","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a specific gene that participates in cellular responses to stimuli. In a study ... | |
medium_hidden_intermediate_09446 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with SUMO1. Experimental data for this gene reports a log2 fold change of 1.074 and an adjusted p-value of 0.01222. Which protein is encoded by this gene? | Alpha-globin transcription factor CP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09446","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with SUMO1. Experimental data for th... | |
medium_hidden_intermediate_09447 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with rectum adenocarcinoma. Evidence for this gene reports a log2 fold change of 1.546 and an adjusted p-value of 0.04039. Which protein is encoded by this gene? | ATP synthase subunit C lysine N-methyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09447","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with rectum adenocarcinoma.... | |
medium_hidden_intermediate_09448 | Vaccinia virus infection leads to the upregulation of certain genes that function as structural constituents of muscle. One such gene exhibits a log2 fold change of 2.372 and an adjusted p-value of 0.0003248 in cervical adenocarcinoma cell lines. In which cell type is this specific gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09448","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection leads to the upregulation of certain genes that function as structural constituents of muscle. One ... | |
medium_hidden_intermediate_09450 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in cell-cell junction organization. Evidence for this gene reports a log2 fold change of 1.571 and an adjusted p-value of 0.04222. Which protein is encoded by this gene? | Claudin-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09450","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in cell-cell junction organizatio... | |
medium_hidden_intermediate_09451 | Zika virus upregulates a gene that participates in Asparagine N-linked glycosylation. Evidence for this specific gene reports a log2 fold change of 1.063 and an adjusted p-value of 0.02895. Which protein is encoded by this gene? | Guanine nucleotide-exchange factor SEC12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09451","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in Asparagine N-linked glycosylation. Evidence for this specific gene report... | |
medium_hidden_intermediate_09452 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in Signaling by Interleukins. One of these genes exhibits a log2 fold change of 1.713 and an adjusted p-value of 0.003848 in macrophages (study GSE108897). Which disease is associated with this specific gene as a biomarker? | scleroderma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09452","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in Signaling by Interleukins. One of these genes... | |
medium_hidden_intermediate_09453 | Hepacivirus C upregulates a gene that participates in cellular responses to stimuli. Evidence for one such gene reports a log2 fold change of 1.501 and an adjusted p-value of 0.04505. Which protein is encoded by that gene? | C-type lectin domain family 1 member B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09453","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in cellular responses to stimuli. Evidence for one such gene reports a lo... | |
medium_hidden_intermediate_09455 | Pegivirus C downregulates a specific gene, the product of which binds to SKP1. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) shows a log2 fold change of -2.358 and an adjusted p-value of 0.0001203. Which protein is encoded by this gene? | F-box only protein 22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09455","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, the product of which binds to SKP1. Experimental data for this gene in peripheral... | |
medium_hidden_intermediate_09456 | Zika virus downregulates a specific gene, which is subsequently found to be enriched in Gamma delta (γδ) T cells. Experimental data for this gene reports a log2 fold change of approximately -1.26 and an adjusted p-value of approximately 0.015. Which protein is encoded by this gene? | NBPF family member NBPF3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09456","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which is subsequently found to be enriched in Gamma delta (γδ) T cells. Experiment... | |
medium_hidden_intermediate_09457 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables integrin binding. Evidence for this gene reports a log2 fold change of -1.181 and an adjusted p-value of 0.006909. Which protein is encoded by this gene? | Disintegrin and metalloproteinase domain-containing protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09457","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables integrin binding. Evidence for this ... | |
medium_hidden_intermediate_09461 | Human immunodeficiency virus 1 upregulates a gene that is located in the mitochondrial membrane. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 1.498 and an adjusted p-value of 0.0001826. Which disease is associated with genomic alterations in this gene? | Fowler syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09461","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the mitochondrial membrane. Evidence for this gene in m... | |
medium_hidden_intermediate_09463 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate certain genes involved in protein K63-linked ubiquitination. One such gene exhibited a log2 fold change of approximately 1.189 and an adjusted p-value of 0.006733. Which protein is encoded b... | E3 ubiquitin-protein ligase KCMF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09463","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_09464 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables transcription coregulator activity. Evidence for one such gene reports a log2 fold change of 1.242 and an adjusted p-value of 0.006791. Which protein is encoded by that gene? | Zinc finger protein 764 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09464","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables transcription coregulator activity. Ev... | |
medium_hidden_intermediate_09468 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specific gene, which in turn interacts with SEPT7. This gene exhibits a log2 fold change of 4.083 and an adjusted p-value of 2.488e-13. Which protein is encoded by this upregulated gene? | Septin-11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09468","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specifi... | |
medium_hidden_intermediate_09469 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and binds to CTNNB1. This gene exhibits a log2 fold change of 1.014 and an adjusted p-value of 0.00711. Which protein is encoded by this gene? | C-terminal-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09469","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and binds to CTNNB1. This gen... | |
medium_hidden_intermediate_09473 | Hepacivirus C upregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for one such gene reports a log2 fold change of 1.344 and an adjusted p-value of 0.04701. Which protein is encoded by that gene? | Solute carrier family 2, facilitated glucose transporter member 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09473","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for one such gene repor... | |
medium_hidden_intermediate_09474 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the degradation of the extracellular matrix. Evidence for one such gene reports a log2 fold change of -1.851 and an adjusted p-value of 0.0007708. Which protein is encoded by that gene? | Matrix metalloproteinase-24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09474","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the degradation of the extra... | |
medium_hidden_intermediate_09475 | Influenza A virus upregulates a gene that participates in Signaling by Rho GTPases. Evidence for one such gene reports a log2 fold change of 1.713 and an adjusted p-value of 3.571e-10. Which protein is encoded by that gene? | Protein FAM13B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09475","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus upregulates a gene that participates in Signaling by Rho GTPases. Evidence for one such gene reports a log... | |
medium_hidden_intermediate_09476 | Zika virus downregulates a gene that participates in GPCR downstream signalling. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.917 and an adjusted p-value of 0.01998. Which protein is encoded by this gene? | Diacylglycerol kinase epsilon | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09476","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in GPCR downstream signalling. In a study of glioma stem cells (GSE114907)... | |
medium_hidden_intermediate_09479 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to SNRPA1. The expression data for this gene shows a log2 fold change of approximately -1.81 and an adjusted p-value of 0.01584. Which protein ... | CWF19-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09479","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_09484 | Two genes are structurally linked from Pegivirus C via a 'downregulates' relationship and subsequently to the biological process 'TP53 Regulates Transcription of Cell Death Genes' via a 'participates in' relationship. One of these genes is reported in study GSE131504 (peripheral blood mononuclear cells) with a log2 fol... | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09484","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Pegivirus C via a 'downregulates' relationship and subsequently to the biological pro... | |
medium_hidden_intermediate_09485 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for bipolar disorder. Evidence for this gene reports a log2 fold change of 2.879 and an adjusted p-value of 0.02749. Which disease is associated with this gene? | pancreatic ductal adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09485","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for bipolar disorde... | |
medium_hidden_intermediate_09486 | Vaccinia virus downregulates a gene that is involved in the epigenetic regulation of gene expression. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibited a log2 fold change of approximately -1.23 and an adjusted p-value of approximately 0.017. Which protein is encoded by this specific g... | Zinc finger CW-type PWWP domain protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09486","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that is involved in the epigenetic regulation of gene expression. In a study of cervical... | |
medium_hidden_intermediate_09487 | Zika virus downregulates a gene that is part of the histone acetyltransferase complex. In glioma stem cells, one such gene exhibits a log2 fold change of -2.109 and an adjusted p-value of 0.004334. Which protein is encoded by this gene? | Histone acetyltransferase KAT8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09487","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is part of the histone acetyltransferase complex. In glioma stem cells, one such gene e... | |
medium_hidden_intermediate_09488 | Enterovirus A upregulates a specific gene, which in turn interacts with STK4. Experimental data for this gene in rhabdomyosarcoma cells reports a log2 fold change of approximately 1.58 and an adjusted p-value of approximately 0.0042. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09488","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a specific gene, which in turn interacts with STK4. Experimental data for this gene in rhabdomyosa... | |
medium_hidden_intermediate_09489 | Primate bocaparvovirus 1 is reported to downregulate a specific gene that participates in p75 NTR receptor-mediated signalling. In a study of tracheobronchial epithelial cells (GSE102392), this gene exhibited a log2 fold change of -1.185 and an adjusted p-value of 0.01692. Which disease is associated with this gene? | malignant glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09489","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Primate bocaparvovirus 1 is reported to downregulate a specific gene that participates in p75 NTR receptor-mediated signalli... |
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