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medium_hidden_intermediate_09490 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and enables zinc ion binding. Evidence for this gene reports a log2 fold change of -1.151 and an adjusted p-value of 0.01466. Which protein is encoded by this gene? | Alcohol dehydrogenase class-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09490","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and enables ... | |
medium_hidden_intermediate_09491 | Severe acute respiratory syndrome-related coronavirus upregulates multiple genes involved in the regulation of response to endoplasmic reticulum stress. One such gene exhibits a log2 fold change of 1.210 and an adjusted p-value of 2.017e-05. Which protein is encoded by this specific gene? | Mesencephalic astrocyte-derived neurotrophic factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09491","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates multiple genes involved in the regulation of response to e... | |
medium_hidden_intermediate_09492 | Vaccinia virus infection leads to the upregulation of specific genes that participate in GPCR downstream signalling. One such gene exhibits a log2 fold change of approximately 7.95 and an adjusted p-value of 0.006166 in cervical adenocarcinoma cell lines. In which cell type is this specific gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09492","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection leads to the upregulation of specific genes that participate in GPCR downstream signalling. One suc... | |
medium_hidden_intermediate_09493 | In a study of non-small cell lung adenocarcinoma cell lines (GSE106279), a gene downregulated by Influenza A virus and involved in the Immune System showed a log2 fold change of -2.106 and an adjusted p-value of 0.03276. Which cell type is this gene enriched in? | intermediate monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09493","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE106279), a gene downregulated by Influenza A virus and invol... | |
medium_hidden_intermediate_09494 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both interact with YWHAZ. One of these genes exhibits a log2 fold change of -1.164 and an adjusted p-value of 0.03101 in a specific study. Which disease is associated with this specific gene? | cystic fibrosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09494","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both interact with YWHAZ. One of th... | |
medium_hidden_intermediate_09496 | Rhinovirus A downregulates a gene that participates in the Adaptive Immune System. In a study of cytotoxic T-lymphocytes (GSE106475), one such gene exhibits a log2 fold change of approximately -1.246 and an adjusted p-value of 0.0001348. Which protein is encoded by this specific gene? | SLAM family member 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09496","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A downregulates a gene that participates in the Adaptive Immune System. In a study of cytotoxic T-lymphocytes (GS... | |
medium_hidden_intermediate_09497 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation of cell migration. Transcriptomic data for this gene shows a log2 fold change of 1.161 and an adjusted p-value of 0.007923. Which disease is associated with this gene as a biomarker? | cervical carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09497","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation of... | |
medium_hidden_intermediate_09498 | Human immunodeficiency virus 1 downregulates a gene that is involved in mitotic spindle assembly. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.244 and an adjusted p-value of 0.002284. Which protein is encoded by this gene? | Kinesin-like protein KIFC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09498","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in mitotic spindle assembly. In a study of macrophages ... | |
medium_hidden_intermediate_09500 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables nuclear estrogen receptor binding. Evidence for one such gene reports a log2 fold change of 2.392 and an adjusted p-value of 0.01014. Which protein is encoded by that gene? | Ligand-dependent corepressor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09500","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables nuclear estrogen receptor binding. Evi... | |
medium_hidden_intermediate_09501 | Zika virus infection leads to the upregulation of certain genes that participate in cell-cell junction organization. One such gene exhibits a log2 fold change of 1.117 and an adjusted p-value of 0.0102 in glioblastoma multiforme cancer stem cells. Which protein is encoded by this specific gene? | Krueppel-like factor 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09501","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the upregulation of certain genes that participate in cell-cell junction organization. One suc... | |
medium_hidden_intermediate_09502 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and is involved in the positive regulation of interleukin-10 production. This specific gene exhibits a log2 fold change of approximately 4.39 and an adjusted p-value of 0.00022. Which protein is encoded by this gene? | T-cell-specific surface glycoprotein CD28 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09502","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and is involved in the ... | |
medium_hidden_intermediate_09503 | Vaccinia virus infection leads to the downregulation of specific genes involved in the regulation of the cell cycle. In a study of cervical adenocarcinoma cell lines (GSE11238), one such downregulated gene exhibited a log2 fold change of approximately -3.35 and an adjusted p-value of 0.00284. Which protein is encoded b... | Cyclin-L1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09503","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection leads to the downregulation of specific genes involved in the regulation of the cell cycle. In a st... | |
medium_hidden_intermediate_09504 | Vaccinia virus infection upregulates a specific gene that participates in GPCR downstream signalling. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibited a log2 fold change of 3.613 and an adjusted p-value of 1.814e-06. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09504","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection upregulates a specific gene that participates in GPCR downstream signalling. In a study of cervical... | |
medium_hidden_intermediate_09505 | Two genes are linked to GNAI3 via a binding interaction and are both enriched in non-classical monocytes. One of these genes is associated with evidence stating: 'Both regions interact exclusively with G alpha(i1), G alpha(i2), and G alpha(i3) in their GDP-bound forms.' Which protein is encoded by the gene supported by... | Regulator of G-protein signaling 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09505","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to GNAI3 via a binding interaction and are both enriched in non-classical monocytes. One of these genes... | |
medium_hidden_intermediate_09507 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in O-linked glycosylation of mucins. One such gene exhibits a log2 fold change of 1.257 and an adjusted p-value of 0.02229. Which protein is encoded by this specific gene? | Beta-1,4-galactosyltransferase 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09507","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in O-linked glyco... | |
medium_hidden_intermediate_09508 | Two biological processes are hierarchically situated between 'positive regulation of meiotic nuclear division' and 'positive regulation of cell cycle' via 'is a' relationships. One of these intermediate processes is defined by the evidence: 'Any process that activates or increases the frequency, rate or extent of meios... | meiotic cell cycle | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09508","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two biological processes are hierarchically situated between 'positive regulation of meiotic nuclear division' and 'positive... | |
medium_hidden_intermediate_09511 | Human mastadenovirus C upregulates a gene that participates in post-translational protein modification. In a study of lung fibroblast cell lines (GSE120891), one such gene exhibited a log2 fold change of 2.020 and an adjusted p-value of 0.04322. Which protein is encoded by this specific gene? | Protein eva-1 homolog A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09511","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human mastadenovirus C upregulates a gene that participates in post-translational protein modification. In a study of lung f... | |
medium_hidden_intermediate_09514 | Cardiovirus A upregulates a gene that is located in the extracellular space. Evidence for one such gene reports a log2 fold change of 1.062 and an adjusted p-value of 0.0119. Which disease is associated with that gene? | altitude sickness | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09514","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that is located in the extracellular space. Evidence for one such gene reports a log2 fold ... | |
medium_hidden_intermediate_09515 | Human alphaherpesvirus 3 is reported to downregulate a gene that participates in the metabolism of lipids. In a study of melanoma cell lines (GSE136586), one such gene exhibited a log2 fold change of -1.169 and an adjusted p-value of 6.646e-05. Which protein is encoded by this specific gene? | Protein phosphatase 1L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09515","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is reported to downregulate a gene that participates in the metabolism of lipids. In a study of mel... | |
medium_hidden_intermediate_09516 | Two genes are upregulated by Human immunodeficiency virus 1 and serve as biomarkers for breast carcinoma. One of these genes exhibits a log2 fold change of 1.977 and an adjusted p-value of 0.002676 in macrophages (study GSE108897). Which cellular component is the location of this specific gene? | endoplasmic reticulum lumen | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09516","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and serve as biomarkers for breast carcinoma. One of these genes... | |
medium_hidden_intermediate_09517 | COPS6 interacts with a specific protein that enables protein binding. Evidence indicates that this protein, when located in the cytoplasm, enhances cellular migration through the ubiquitination and destruction of E-cadherin. Which cellular component is this protein located in? | SCF ubiquitin ligase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09517","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"COPS6 interacts with a specific protein that enables protein binding. Evidence indicates that this protein, when located in ... | |
medium_hidden_intermediate_09518 | Human alphaherpesvirus 1 upregulates a gene that interacts with STK4. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibits a log2 fold change of approximately 1.05 and an adjusted p-value of approximately 0.003. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09518","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that interacts with STK4. In a study of monocytic leukemia cell lines (GSE114966... | |
medium_hidden_intermediate_09520 | Hepacivirus C upregulates a gene that is involved in the innate immune response in mucosa. One such gene exhibits a log2 fold change of 4.110 and an adjusted p-value of 3.938e-05. Which protein is encoded by this gene? | Neutrophil defensin 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09520","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the innate immune response in mucosa. One such gene exhibits a log2 fol... | |
medium_hidden_intermediate_09521 | PDHA1 interacts with a protein that is located in the mitochondrion. Evidence states: 'We have confirmed the mitochondrial localization of FASTKD2 and shown that all FASTKD family members are found in mitochondria.' Which biological process is this protein involved in? | mitochondrial RNA processing | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09521","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PDHA1 interacts with a protein that is located in the mitochondrion. Evidence states: 'We have confirmed the mitochondrial l... | |
medium_hidden_intermediate_09522 | EPHA2 interacts with a protein that is located in the plasma membrane. A specific point mutation (G306E) in the TKB region of this protein has been reported to abolish its binding to receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases, thereby impairing its binding to active EphA2. Which protein is encod... | E3 ubiquitin-protein ligase CBL | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09522","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"EPHA2 interacts with a protein that is located in the plasma membrane. A specific point mutation (G306E) in the TKB region o... | |
medium_hidden_intermediate_09523 | Zika virus downregulates a gene that is involved in DNA replication. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -1.22 and an adjusted p-value of approximately 0.0063. Which protein is encoded by this specific gene? | Transforming growth factor beta regulator 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09523","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in DNA replication. In a study of glioma stem cells (GSE114907), one such g... | |
medium_hidden_intermediate_09525 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in Signaling by Interleukins. This specific gene exhibits a log2 fold change of 2.657 and an adjusted p-value of 0.0002363. Which protein is encoded by this gene? | Thymic stromal lymphopoietin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09525","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in Signaling... | |
medium_hidden_intermediate_09526 | DYNLL1 interacts with a specific protein that enables protein binding. Evidence indicates that two isoforms of DYRK, DYRK1A and this interaction partner, co-immunoprecipitate with HAN11 when coexpressed in COS cells, demonstrating their interaction in mammalian cells. Which cellular component is this interaction partne... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09526","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"DYNLL1 interacts with a specific protein that enables protein binding. Evidence indicates that two isoforms of DYRK, DYRK1A ... | |
medium_hidden_intermediate_09527 | Hepacivirus C upregulates a specific gene that is located in chromatin. Experimental data for this gene shows a log2 fold change of 2.071 and an adjusted p-value of 0.01476. Which biological process is this gene involved in? | negative regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09527","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a specific gene that is located in chromatin. Experimental data for this gene shows a log2 fold ch... | |
medium_hidden_intermediate_09530 | Pegivirus C is reported to downregulate a specific gene that is involved in vesicle fusion. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of approximately -1.96 and an adjusted p-value of approximately 0.035. Which cell type is this gene enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09530","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that is involved in vesicle fusion. In a study of peripheral blood m... | |
medium_hidden_intermediate_09532 | Human immunodeficiency virus 1 upregulates a gene that participates in cellular responses to stress. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately 1.157 and an adjusted p-value of approximately 0.0046. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09532","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in cellular responses to stress. Evidence for this gene ... | |
medium_hidden_intermediate_09533 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables calmodulin binding. Evidence for this gene reports a log2 fold change of approximately 5.002 and an adjusted p-value of 0.005229. Which protein is encoded by this gene? | Intermediate conductance calcium-activated potassium channel protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09533","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables calmodulin binding. Evidence for this ... | |
medium_hidden_intermediate_09534 | In a study of bronchial epithelial cells (GSE153218), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn participates in the expression and translocation of olfactory receptors. Evidence for this specific gene reports a log2 fold change of 1.675 and an adjusted ... | Olfactory receptor 56B1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09534","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells (GSE153218), Severe acute respiratory syndrome-related coronavirus was found to upr... | |
medium_hidden_intermediate_09535 | A gene is upregulated by Primate bocaparvovirus 1 and enriched in natural killer cells. Evidence for this gene reports a log2 fold change of 1.754 and an adjusted p-value of 0.04446. Which biological process is this gene involved in? | response to cold | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09535","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and enriched in natural killer cells. Evidence for this gene reports a log... | |
medium_hidden_intermediate_09536 | A gene is downregulated by Cardiovirus A and located in the endoplasmic reticulum. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.067 and an adjusted p-value of 0.008743. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09536","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and located in the endoplasmic reticulum. Experimental data for this gene in a cerv... | |
medium_hidden_intermediate_09537 | Two genes are structurally linked to Pegivirus C via downregulation and to Phospholipid metabolism via participation. One of these genes exhibits a log2 fold change of -1.255 and an adjusted p-value of 0.007967 in peripheral blood mononuclear cells (study GSE131504). Which gene is this, and what entity does it bind to? | CHKB | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09537","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to Phospholipid metabolism via participation. One of... | |
medium_hidden_intermediate_09538 | Human betaherpesvirus 5 is reported to downregulate a gene whose product is located in the actin cytoskeleton. In a study of foreskin fibroblast cell lines, one such gene exhibited a log2 fold change of approximately -1.24 and an adjusted p-value of 0.036. Which protein is encoded by this specific gene? | Destrin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09538","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene whose product is located in the actin cytoskeleton. In a study of... | |
medium_hidden_intermediate_09539 | Human alphaherpesvirus 3 is reported to upregulate a gene that is enriched in non-classical monocytes. Evidence for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately 2.425 and an adjusted p-value of 0.0001773. Which protein is encoded by this gene? | Bcl-2-related protein A1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09539","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is reported to upregulate a gene that is enriched in non-classical monocytes. Evidence for this gen... | |
medium_hidden_intermediate_09540 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene that participates in the extension of telomeres. This gene exhibited a log2 fold change of approximately -2.01 and an adjusted p-value of 0.0119. Which protein is encoded by this gene? | ATP-dependent DNA helicase PIF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09540","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_09541 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the synthesis of substrates in N-glycan biosynthesis. Evidence for one such gene reports a log2 fold change of -1.518 and an adjusted p-value of 0.04995. Which molecular function is enabled by that gene? | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09541","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the synthesis of substrates ... | |
medium_hidden_intermediate_09543 | Pegivirus C is reported to downregulate a gene that is involved in chemical synaptic transmission. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of approximately -1.03 and an adjusted p-value of approximately 0.00029. Which protein is encoded by this specific gene... | Synaptophysin-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09543","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in chemical synaptic transmission. In a study of peripheral ... | |
medium_hidden_intermediate_09544 | Hepacivirus C is associated with the downregulation of a gene involved in actin cytoskeleton organization. Evidence for one such gene reports a log2 fold change of -2.931 and an adjusted p-value of 0.02214. Which protein is encoded by that gene? | Cdc42 effector protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09544","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a gene involved in actin cytoskeleton organization. Evidence for one ... | |
medium_hidden_intermediate_09545 | Human betaherpesvirus 5 upregulates a gene that is located in the membrane. Evidence for this gene reports a log2 fold change of 1.083 and an adjusted p-value of 0.0003625. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09545","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is located in the membrane. Evidence for this gene reports a log2 fold chang... | |
medium_hidden_intermediate_09547 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to bind POLR2D exhibits a log2 fold change of 1.712 and an adjusted p-value of 3.054e-10. Which gene interacts with this specific entity? | MEPCE | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09547","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to bind POLR2D e... | |
medium_hidden_intermediate_09548 | Zika virus downregulates a gene that is located in the nucleoplasm. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.32 and an adjusted p-value of approximately 0.03. Which protein does this gene product interact with? | RBM39 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09548","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the nucleoplasm. Experimental data for this gene in glioma stem cells (st... | |
medium_hidden_intermediate_09550 | Nerve sheath neoplasms can be localized to specific cranial nerves. One such cranial nerve is characterized by its role in transmitting sound and equilibrium (balance) information from the inner ear to the brain. Which anatomical system is this specific cranial nerve a part of? | vestibulo-auditory system | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09550","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Nerve sheath neoplasms can be localized to specific cranial nerves. One such cranial nerve is characterized by its role in t... | |
medium_hidden_intermediate_09552 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to the RHOQ GTPase cycle via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -1.04 and an adjusted p-val... | ARF GTPase-activating protein GIT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09552","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_09554 | Human betaherpesvirus 5 downregulates a gene that interacts with PRNP. In a study using foreskin fibroblast cell lines (GSE111036), one such gene exhibits a log2 fold change of approximately -1.815 and an adjusted p-value of 0.03822. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09554","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that interacts with PRNP. In a study using foreskin fibroblast cell lines (GSE1... | |
medium_hidden_intermediate_09555 | A gene is downregulated by Primate bocaparvovirus 1 and participates in Signal Transduction. Experimental evidence for this gene reports a log2 fold change of -1.247 and an adjusted p-value of 0.0417. Which biological process is this gene involved in? | negative regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09555","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in Signal Transduction. Experimental evidence for this ... | |
medium_hidden_intermediate_09556 | Zika virus downregulates a gene that is located in the late endosome. Evidence for this gene reports a log2 fold change of -1.021 and an adjusted p-value of 0.01753. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09556","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the late endosome. Evidence for this gene reports a log2 fold change of -... | |
medium_hidden_intermediate_09557 | Hepacivirus C is reported to downregulate a gene that is located in the cytosol. Evidence for one such gene indicates a log2 fold change of -2.039 and an adjusted p-value of 0.001409. Which disease is associated with this specific gene? | follicular lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09557","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is located in the cytosol. Evidence for one such gene indicates a log2... | |
medium_hidden_intermediate_09558 | Astrocytes express multiple markers that interact with SMURF1. One such marker is known to interact with SMURF1, which promotes its ubiquitination and degradation. Which disease is associated with this specific marker? | ureteral obstruction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09558","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Astrocytes express multiple markers that interact with SMURF1. One such marker is known to interact with SMURF1, which promo... | |
medium_hidden_intermediate_09559 | SH3KBP1 interacts with a protein that participates in Signal Transduction. Evidence regarding one such interacting partner states: 'Yeast two-hybrid screening of a p53(-/-) astrocyte cDNA library with this SH3 domain identified a novel gene, SETA binding protein 1 (the interacting partner), with 55% amino acid identity... | SH3KBP1-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09559","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"SH3KBP1 interacts with a protein that participates in Signal Transduction. Evidence regarding one such interacting partner s... | |
medium_hidden_intermediate_09560 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to cervical carcinoma via an 'associated with' relationship. One of these genes has been reported in a study (GSE157852) involving choroid plexus epithelium cells, showing a log2 fold change... | sequence-specific double-stranded DNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09560","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_09561 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of specific genes that are enriched in regulatory T cells. One such gene exhibits a log2 fold change of approximately 4.53 and an adjusted p-value of 5.03e-08. What molecular function is enabled by this speci... | RNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09561","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of specific ... | |
medium_hidden_intermediate_09562 | A specific gene serves as a marker for Natural killer T (NKT) cells and interacts with HSP90AA1. Evidence indicates that this gene exhibits lymphoid-restricted expression, and coimmunoprecipitation studies demonstrate that its expression in myeloma cells is regulated via direct association with the heat shock protein 9... | melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09562","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene serves as a marker for Natural killer T (NKT) cells and interacts with HSP90AA1. Evidence indicates that thi... | |
medium_hidden_intermediate_09563 | Two genes are identified as markers in meiotic prophase fetal germ cells and both enable DNA binding. One of these genes encodes a meiosis-specific protein in yeast that is covalently bound to DNA double-strand breaks (DSBs) during the early stages of meiosis. Which disease is associated with genomic alterations in thi... | azoospermia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09563","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers in meiotic prophase fetal germ cells and both enable DNA binding. One of these genes enc... | |
medium_hidden_intermediate_09564 | Zika virus upregulates a gene that binds to UBA52. Experimental data for this gene reports a log2 fold change of approximately 1.806 and an adjusted p-value of 0.01229. Which disease is associated with this gene? | preeclampsia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09564","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that binds to UBA52. Experimental data for this gene reports a log2 fold change of approximate... | |
medium_hidden_intermediate_09565 | A gene is downregulated by Primate bocaparvovirus 1 and participates in cellular responses to stimuli. Experimental evidence for this gene reports a log2 fold change of -1.666 and an adjusted p-value of 0.001038. Which disease is associated with this gene as a biomarker? | laryngeal squamous cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09565","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in cellular responses to stimuli. Experimental evidence... | |
medium_hidden_intermediate_09566 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the ephrin receptor signaling pathway. Evidence for one such gene reports a log2 fold change of -1.342 and an adjusted p-value of 0.00159. Which protein is encoded by that gene? | Ephrin type-A receptor 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09566","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the ephrin receptor signaling... | |
medium_hidden_intermediate_09568 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in midbody abscission. One of these genes was reported in a study on cardiomyocyte cell lines with a log2 fold change of 1.366 and an adjusted p-value of 0.007264. Which gene interacts with the gene identified by this ex... | MTMR4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09568","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in midbody abscission. O... | |
medium_hidden_intermediate_09571 | Pegivirus C is reported to downregulate a specific gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. Transcriptomic data for this gene indicates a log2 fold change of approximately -1.605 and an adjusted p-value of 0.02742. Which cell type is this gene enriched in? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09571","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that is involved in the proteasome-mediated ubiquitin-dependent prot... | |
medium_hidden_intermediate_09572 | Human betaherpesvirus 5 is reported to downregulate a specific gene that participates in biological oxidations. Experimental data for this gene in foreskin fibroblast cell lines indicates a log2 fold change of approximately -1.748 and an adjusted p-value of 0.04943. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09572","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene that participates in biological oxidations. Experimental... | |
medium_hidden_intermediate_09573 | Human betaherpesvirus 5 upregulates a gene that enables serine-type endopeptidase inhibitor activity. In a study of foreskin fibroblast cell lines (GSE130665), one such gene showed a log2 fold change of approximately 1.32 and an adjusted p-value of 0.003781. Which protein is encoded by this specific gene? | Corticosteroid-binding globulin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09573","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that enables serine-type endopeptidase inhibitor activity. In a study of foreskin... | |
medium_hidden_intermediate_09574 | Zika virus downregulates a specific gene that participates in Phase I - Functionalization of compounds. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.354 and an adjusted p-value of 0.0143. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09574","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in Phase I - Functionalization of compounds. Evidence for this ge... | |
medium_hidden_intermediate_09575 | Measles morbillivirus is reported to upregulate a gene that is associated with squamous cell carcinoma. One such gene exhibits a log2 fold change of 2.828 and an adjusted p-value of 0.0002907 in a specific study. Which protein is encoded by this gene? | Cell division cycle-associated protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09575","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus is reported to upregulate a gene that is associated with squamous cell carcinoma. One such gene exhibi... | |
medium_hidden_intermediate_09576 | Two genes are structurally linked to Pegivirus C via downregulation and to MATR3 via interaction. One of these genes exhibits a log2 fold change of -2.958 and an adjusted p-value of 0.008781 in a specific study. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09576","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to MATR3 via interaction. One of these genes exhibit... | |
medium_hidden_intermediate_09577 | Rhinovirus A infection leads to the downregulation of specific genes that enable DNA-binding transcription repressor activity, RNA polymerase II-specific. In a study of cytotoxic T-lymphocytes (GSE106475), one such gene exhibited a log2 fold change of -1.318 and an adjusted p-value of 8.586e-05. Which protein is encode... | Transcription factor EC | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09577","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of specific genes that enable DNA-binding transcription repressor activit... | |
medium_hidden_intermediate_09578 | Zika virus downregulates a gene that is involved in hemopoiesis. Experimental data from glioma stem cells (study GSE114907) indicates that this specific gene has a log2 fold change of approximately -1.047 and an adjusted p-value of 0.02135. Which protein is encoded by this gene? | Sialomucin core protein 24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09578","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in hemopoiesis. Experimental data from glioma stem cells (study GSE114907) ... | |
medium_hidden_intermediate_09580 | Human betaherpesvirus 5 is reported to upregulate a gene that is enriched in intermediate monocytes. Evidence for this specific gene in foreskin fibroblast cell lines (study GSE132081) indicates a log2 fold change of approximately 1.329 and an adjusted p-value of 3.109e-06. Which protein is encoded by this gene? | Exocyst complex component 3-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09580","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is enriched in intermediate monocytes. Evidence for this speci... | |
medium_hidden_intermediate_09582 | Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the response to ionizing radiation. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibited a log2 fold change of -1.131 and an adjusted p-value of 0.04684. Which protein is encoded by this specific gene? | Ubiquitin carboxyl-terminal hydrolase 28 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09582","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the response to ionizing radiation. In a stud... | |
medium_hidden_intermediate_09583 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the activin receptor signaling pathway. Evidence for this gene reports a log2 fold change of -1.894 and an adjusted p-value of 2.09e-05. Which disease is connected to this gene through genomic alterations? | congestive heart failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09583","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the activin receptor sig... | |
medium_hidden_intermediate_09588 | Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to Class I MHC mediated antigen processing & presentation via a participation relationship. One of these genes is reported in a study with a log2 fold change of approximately 1.094 and an adjusted p-value of 0.02969. Which d... | prostate carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09588","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to Class I MHC mediated anti... | |
medium_hidden_intermediate_09589 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the regulation of DNA-templated transcription. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this gene exhibits a log2 fold change of -1.338 and an adjusted p-value of 0.005425. Whic... | RNA exonuclease 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09589","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the regulation of DNA-templated t... | |
medium_hidden_intermediate_09590 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with RNF10. One of these genes exhibits a log2 fold change of approximately -1.000 and an adjusted p-value of 0.003592 in lung cells. Which cellular component is this specific gene located in? | chromosome, telomeric region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09590","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with RNF10. One of these g... | |
medium_hidden_intermediate_09591 | Pegivirus C is reported to downregulate a gene that participates in the RHO GTPase cycle. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -2.261 and an adjusted p-value of 0.002457. Which protein is encoded by this specific gene? | Serine/threonine-protein kinase 38 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09591","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in the RHO GTPase cycle. In a study of peripheral blood mon... | |
medium_hidden_intermediate_09594 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the process where XBP1(S) activates chaperone genes. Evidence for one such gene reports a log2 fold change of 1.090 and an adjusted p-value of 4.202e-06. Which protein is encoded by that gene? | Protein disulfide-isomerase A6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09594","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the process where XBP1(S) acti... | |
medium_hidden_intermediate_09595 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the negative regulation of epigenetic gene expression. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of approximately -2.37 and an adjusted p-value of 0.0016. Which gene inte... | TP53 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09595","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the negative regulation of epigen... | |
medium_hidden_intermediate_09599 | Zika virus downregulates multiple genes involved in retrograde vesicle-mediated transport from the Golgi to the endoplasmic reticulum. One such gene exhibits a log2 fold change of approximately -2.58 and an adjusted p-value of 0.0015 in glioma stem cells. Which protein is encoded by this specific gene? | Transmembrane protein 115 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09599","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes involved in retrograde vesicle-mediated transport from the Golgi to the endoplasmic ... | |
medium_hidden_intermediate_09600 | In a study of non-small cell lung adenocarcinoma, Influenza A virus infection was found to upregulate a specific gene, which in turn binds to GNAI1. The expression data for this gene shows a log2 fold change of approximately 1.30 and an adjusted p-value of 0.012. Which protein is encoded by this gene? | C-C chemokine receptor type 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09600","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma, Influenza A virus infection was found to upregulate a specific gene, which... | |
medium_hidden_intermediate_09601 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and binds to POU2F1. This gene exhibits a log2 fold change of approximately -1.49 and an adjusted p-value of 0.0077. Which protein is encoded by this gene? | DNA-directed RNA polymerase III subunit RPC3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09601","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and binds to POU2F1. Th... | |
medium_hidden_intermediate_09602 | Measles morbillivirus upregulates a gene that is involved in protein phosphorylation. Evidence for one such gene reports a log2 fold change of 1.133 and an adjusted p-value of 0.02885. Which protein is encoded by that gene? | Cyclin-dependent kinase 17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09602","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in protein phosphorylation. Evidence for one such gene reports a l... | |
medium_hidden_intermediate_09603 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and involved in the positive regulation of canonical NF-kappaB signal transduction. This specific gene exhibits a log2 fold change of -1.263 and an adjusted p-value of 0.002497. Which protein does this ge... | ITCH | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09603","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and invo... | |
medium_hidden_intermediate_09604 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Phospholipid metabolism. One such gene exhibits a log2 fold change of 2.223 and an adjusted p-value of 3.126e-05. Which gene interacts with this specific upregulated gene? | PPP2R1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09604","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Phospholipid m... | |
medium_hidden_intermediate_09605 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a gene that enables metalloendopeptidase activity. One such gene exhibited a log2 fold change of -3.714 and an adjusted p-value of 0.004232. Which cellular component is this specific gene located in? | extracellular region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09605","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a gene that enables meta... | |
medium_hidden_intermediate_09606 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of specific genes involved in vesicle-mediated transport. One such gene exhibits a log2 fold change of -1.060 and an adjusted p-value of 0.01391. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09606","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of specifi... | |
medium_hidden_intermediate_09607 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in platelet activation, signaling, and aggregation showed a log2 fold change of 2.700 and an adjusted p-value of 4.663e-13. Which protein is encoded by this gene? | Saccharopine dehydrogenase-like oxidoreductase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09607","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in platelet a... | |
medium_hidden_intermediate_09608 | A gene is downregulated by Cardiovirus A and enriched in plasmacytoid dendritic cells. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.195 and an adjusted p-value of 0.01496. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09608","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and enriched in plasmacytoid dendritic cells. Evidence for this gene in a cervical ... | |
medium_hidden_intermediate_09609 | Pegivirus C is reported to downregulate a gene that enables sialyltransferase activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -2.21 and an adjusted p-value of 0.0002188. Which protein is encoded by this specific gene? | Beta-galactoside alpha-2,6-sialyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09609","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables sialyltransferase activity. In a study of peripheral blood monon... | |
medium_hidden_intermediate_09610 | Two genes are upregulated by Vaccinia virus and are both associated with polyarticular arthritis. One of these genes exhibits a log2 fold change of approximately 1.75 and an adjusted p-value of approximately 1.12e-05 in cervical adenocarcinoma cell lines. Which disease is linked to this specific gene via a biomarker re... | aspergillosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09610","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and are both associated with polyarticular arthritis. One of these genes exhibit... | |
medium_hidden_intermediate_09611 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in immunoregulatory interactions between a lymphoid and a non-lymphoid cell. Evidence for one such gene reports a log2 fold change of 1.313 and an adjusted p-value of 3.187e-06. Which molecular function is enabled by that gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09611","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in immunoregulatory interactions ... | |
medium_hidden_intermediate_09613 | Human betaherpesvirus 5 is reported to upregulate a gene that participates in the Cell Cycle. In a study using foreskin fibroblast cell lines, one such gene exhibited a log2 fold change of 4.486 and an adjusted p-value of 0.0288. Which protein is encoded by this specific gene? | Histone H4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09613","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that participates in the Cell Cycle. In a study using foreskin fibr... | |
medium_hidden_intermediate_09614 | Two genes are upregulated by Vaccinia virus and interact with HIST1H2BG. One of these genes exhibits a log2 fold change of 3.842 and an adjusted p-value of 2.254e-11 in cervical adenocarcinoma cell lines. Which cell type is this specific gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09614","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with HIST1H2BG. One of these genes exhibits a log2 fold change of 3... | |
medium_hidden_intermediate_09616 | Two genes are upregulated by Vaccinia virus and associated with glioma. One of these genes shows a log2 fold change of 1.904 and an adjusted p-value of 1.347e-10 in cervical adenocarcinoma cell lines (study GSE11238). Which gene interacts with the gene exhibiting these specific expression statistics? | RCC1L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09616","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with glioma. One of these genes shows a log2 fold change of 1.904... | |
medium_hidden_intermediate_09617 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is downregulated and participates in membrane trafficking. This gene exhibits a log2 fold change of approximately -1.52 and an adjusted p-value of 0.0167. Which cellular component is this gene located in? | autophagosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09617","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is downregulated and participates ... | |
medium_hidden_intermediate_09618 | Pegivirus C downregulates a gene that participates in TBC/RABGAPs. Evidence for this gene reports a log2 fold change of -1.313 and an adjusted p-value of 0.0003664. Which protein is encoded by this gene? | TBC1 domain family member 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09618","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in TBC/RABGAPs. Evidence for this gene reports a log2 fold change of -1.3... | |
medium_hidden_intermediate_09619 | Human polyomavirus 1 upregulates a gene that enables protein binding. In a study of renal epithelial cells (GSE135833), this gene exhibited a log2 fold change of 2.367 and an adjusted p-value of 0.02322. Which protein is encoded by this gene? | Zinc finger protein 765 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09619","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that enables protein binding. In a study of renal epithelial cells (GSE135833), this... | |
medium_hidden_intermediate_09621 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of the canonical Wnt signaling pathway. One of these genes exhibits a log2 fold change of 1.275 and an adjusted p-value of 0.01608 in lung tissue data from study GSE155241. Which disease is ass... | Lui-Jee-Baron syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09621","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulati... | |
medium_hidden_intermediate_09622 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enriched in Peripheral blood mononuclear cells (PBMCs). Experimental data for this gene reports a log2 fold change of -2.775 and an adjusted p-value of 0.01213. Which molecular function is enabled by this gene? | polyamine oxidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09622","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enriched in Peripheral blood mononuclea... | |
medium_hidden_intermediate_09626 | Human polyomavirus 1 upregulates a gene that enables protein binding. Evidence for this gene in renal epithelial cells reports a log2 fold change of approximately 1.88 and an adjusted p-value of approximately 0.027. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09626","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that enables protein binding. Evidence for this gene in renal epithelial cells repor... |
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