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medium_hidden_intermediate_09627 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with SKP1. Experimental data for this gene in choroid plexus epithelium shows a log2 fold change of 1.432 and an adjusted p-value of 5.051e-05. Which protein is encoded by this gene? | F-box only protein 16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09627","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with SKP1. Experimental data for thi... | |
medium_hidden_intermediate_09628 | A genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is associated with a gene that encodes a protein located in the membrane. Evidence regarding this protein states: 'Primary structure analysis of the protein based on the nucleotide sequence revealed a putative amino-terminal membrane insertion signal pept... | UDP-glucuronosyltransferase 2B17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09628","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is associated with a gene that encodes a protein located in... | |
medium_hidden_intermediate_09630 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene product, which is subsequently associated with retinal degeneration. One such intermediate entity was reported with a log2 fold change of approximately 1.18 and an adjusted p-value of 0.0475. Which pro... | Nuclear protein MDM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09630","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene produ... | |
medium_hidden_intermediate_09632 | Zika virus downregulates a gene that enables membrane insertase activity. In glioma stem cells, one such gene exhibits a log2 fold change of -2.464 and an adjusted p-value of 0.01179. Which protein is encoded by this gene? | Cytochrome c oxidase assembly protein COX18, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09632","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables membrane insertase activity. In glioma stem cells, one such gene exhibits a log... | |
medium_hidden_intermediate_09633 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both bind to YWHAH. One of these genes shows a log2 fold change of approximately 2.02 and an adjusted p-value of 0.0226 in a specific study. Which disease is associated with this gene as a biomarker? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09633","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both bind to YWHAH. One of these gene... | |
medium_hidden_intermediate_09634 | Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for adenocarcinoma. One of these genes was reported in a study (GSE164073) involving sclera cells, with a log2 fold change of approximately 1.326 and an adjusted p-value of 0.00088. Which protein does this sp... | CCNF | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09634","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for adenocar... | |
medium_hidden_intermediate_09635 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the immune response. Evidence for one such gene reports a log2 fold change of -1.379 and an adjusted p-value of 3.301e-10. Which protein is encoded by that gene? | T-cell surface glycoprotein CD1e, membrane-associated | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09635","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the immune response. Evidence... | |
medium_hidden_intermediate_09638 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, multiple genes are upregulated and subsequently found in extracellular exosomes. One such gene exhibits a log2 fold change of approximately 1.316 and an adjusted p-value of 1.964e-07. What molecular function is enabled by this speci... | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09638","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, multiple genes are upregulated and s... | |
medium_hidden_intermediate_09641 | Zika virus upregulates a gene that is involved in the positive regulation of cell population proliferation. Evidence for this gene shows a log2 fold change of 1.222 and an adjusted p-value of 0.0425. Which protein is encoded by this gene? | SERTA domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09641","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is involved in the positive regulation of cell population proliferation. Evidence for thi... | |
medium_hidden_intermediate_09642 | Two genes are each downregulated by Human betaherpesvirus 5 and associated with adenoviridae infectious disease. One of these genes exhibits a log2 fold change of -1.216 and an adjusted p-value of 0.04117 in foreskin fibroblast cell lines. Which protein does this specific gene interact with? | PNPLA2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09642","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Human betaherpesvirus 5 and associated with adenoviridae infectious disease. One of thes... | |
medium_hidden_intermediate_09643 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to the negative regulation of insulin receptor signaling pathway via an 'involved in' relationship. One of these genes is associated with experimental data showing a log2 fold change of 1.029... | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09643","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_09644 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the Cajal body. One of these genes has a reported log2 fold change of 1.664 and an adjusted p-value of 1.259e-05. Which protein is encoded by this specific gene? | U7 snRNA-associated Sm-like protein LSm10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09644","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the Cajal body. One of... | |
medium_hidden_intermediate_09645 | In the hematopoietic hierarchy, basophil differentiation is enabled by a specific progenitor cell, which is a type of granulocytopoietic cell. Consider a cell type described as capable of giving rise to both basophils and mast cells. This cell is characterized by being CD34-positive, CD117-positive, CD125-positive, Fce... | granulocyte monocyte progenitor cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09645","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the hematopoietic hierarchy, basophil differentiation is enabled by a specific progenitor cell, which is a type of granul... | |
medium_hidden_intermediate_09646 | The protein ANK3 is involved in a biological process that is a subtype of membrane organization. One such process is defined as a cellular-level activity resulting in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. Which biological process is this specific entity a part of? | endomembrane system organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09646","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The protein ANK3 is involved in a biological process that is a subtype of membrane organization. One such process is defined... | |
medium_hidden_intermediate_09647 | Measles morbillivirus upregulates a gene that is involved in the mitotic cell cycle. In a study of pleural mesothelioma cells (GSE117668), one such gene showed a log2 fold change of approximately 1.067 and an adjusted p-value of 0.001036. Which protein is encoded by this specific gene? | PHD finger protein 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09647","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the mitotic cell cycle. In a study of pleural mesothelioma cell... | |
medium_hidden_intermediate_09648 | GFRA3 is involved in a biological process that is a type of system development. Evidence for one such process states: 'The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.' Which anatomical structure is the result of the development of this specific ... | nervous system | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09648","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GFRA3 is involved in a biological process that is a type of system development. Evidence for one such process states: 'The p... | |
medium_hidden_intermediate_09650 | Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to ANLN via an interaction relationship. One of these genes is reported in a study (GSE125686) involving natural killer cells, with a log2 fold change of approximately 1.44 and an adjusted p-value of approximately 0... | RNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09650","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to ANLN via an inte... | |
medium_hidden_intermediate_09651 | Zaire ebolavirus downregulates a gene that is enriched in eosinophils. Evidence for this gene in a retinal pigment epithelium cell line (study GSE100839) reports a log2 fold change of -1.184 and an adjusted p-value of 3.603e-06. Which protein is encoded by this gene? | Inositol-trisphosphate 3-kinase B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09651","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that is enriched in eosinophils. Evidence for this gene in a retinal pigment epitheliu... | |
medium_hidden_intermediate_09652 | Two genes are structurally linked from Human immunodeficiency virus 1 via a downregulation relationship and onward to adenoviridae infectious disease via an association. One of these genes exhibits a log2 fold change of -2.420 and an adjusted p-value of 0.005432 in macrophages (study GSE108897). Which biological proces... | response to virus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09652","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human immunodeficiency virus 1 via a downregulation relationship and onward to adenov... | |
medium_hidden_intermediate_09655 | Human betaherpesvirus 5 upregulates a gene that participates in the Innate Immune System. Evidence for this gene reports a log2 fold change of 1.213 and an adjusted p-value of 0.008876. Which gene interacts with this upregulated gene? | STK4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09655","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the Innate Immune System. Evidence for this gene reports a l... | |
medium_hidden_intermediate_09658 | Two genes are structurally linked to Measles morbillivirus via a 'downregulates' relationship and to protein homodimerization activity via an 'enables' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -1.029 and an adjusted p-value of approximately 0.0005... | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09658","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via a 'downregulates' relationship and to protein homodimerizatio... | |
medium_hidden_intermediate_09659 | Human betaherpesvirus 5 is reported to downregulate a gene that is located in the endoplasmic reticulum membrane. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibits a log2 fold change of -1.504 and an adjusted p-value of 0.04876. Which protein is encoded by this specific gene? | Transmembrane protein 41B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09659","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is located in the endoplasmic reticulum membrane. In a study... | |
medium_hidden_intermediate_09660 | Two genes are structurally linked in a pathway starting from Human immunodeficiency virus 1 (via downregulation) and ending at amyloidosis (via association). One of these genes exhibits a log2 fold change of approximately -4.71 and an adjusted p-value of 0.0056 in macrophages from study GSE108897. Which cellular compon... | filopodium membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09660","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked in a pathway starting from Human immunodeficiency virus 1 (via downregulation) and ending ... | |
medium_hidden_intermediate_09661 | A urinary bladder neoplasm is localized to an anatomical structure that is a mesoderm-derived structure. Evidence concerning one such entity describes it as a fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, this entity is joined b... | lower urinary tract | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09661","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A urinary bladder neoplasm is localized to an anatomical structure that is a mesoderm-derived structure. Evidence concerning... | |
medium_hidden_intermediate_09662 | A gene is downregulated by Cardiovirus A and is involved in the positive regulation of transcription by RNA polymerase II. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.340 and an adjusted p-value of 0.0124. Which disease is associated with thi... | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09662","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and is involved in the positive regulation of transcription by RNA polymerase II. E... | |
medium_hidden_intermediate_09663 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cell junction organization. Experimental data for this gene reports a log2 fold change of -1.035 and an adjusted p-value of 0.01708. Which protein is encoded by this gene? | Signal peptidase complex catalytic subunit SEC11A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09663","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cell junction organizat... | |
medium_hidden_intermediate_09664 | Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the regulation of cytokinesis. Experimental data for this gene in foreskin fibroblast cell lines (study GSE111036) show a log2 fold change of -1.215 and an adjusted p-value of 0.044. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09664","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the regulation of cytokinesis. Experimental d... | |
medium_hidden_intermediate_09665 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with hepatocellular carcinoma. One of these genes exhibits a log2 fold change of 1.168 and an adjusted p-value of 0.004893 in a specific study. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09665","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with hepatocellular ca... | |
medium_hidden_intermediate_09667 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that interacts with HIST1H4A. One such gene exhibits a log2 fold change of 1.539 and an adjusted p-value of 0.00111. Which protein is encoded by this specific gene? | Putative E3 ubiquitin-protein ligase UBR7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09667","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that interacts with HIST1H4A.... | |
medium_hidden_intermediate_09668 | Rhinovirus A upregulates a specific gene that is associated with aneuploidy. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 2.21 and an adjusted p-value of 0.0027. Which disease is linked to this gene as a biomarker? | intestinal obstruction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09668","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A upregulates a specific gene that is associated with aneuploidy. Evidence for this gene in cytotoxic T-lymphocyt... | |
medium_hidden_intermediate_09669 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to Hemostasis via a participation relationship. One of these genes exhibits a log2 fold change of -4.064 and an adjusted p-value of 0.008813 in a specific study. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09669","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to Hemostasis via ... | |
medium_hidden_intermediate_09670 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that enables phosphoprotein phosphatase activity. One such gene exhibited a log2 fold change of -2.038 and an adjusted p-value of 0.006651. Which protein is encoded by this specific gene? | Chronophin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09670","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that enables phosphop... | |
medium_hidden_intermediate_09672 | Two genes are structurally linked to Pegivirus C via downregulation and to SNRPF via interaction. One of these genes exhibits a log2 fold change of -1.721 and an adjusted p-value of 0.00105 in peripheral blood mononuclear cells. Which cell type is this specific gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09672","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to SNRPF via interaction. One of these genes exhibit... | |
medium_hidden_intermediate_09673 | Zika virus downregulates a gene that participates in the metabolism of vitamins and cofactors. Evidence for this specific gene reports a log2 fold change of -1.149 and an adjusted p-value of 0.0379. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09673","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the metabolism of vitamins and cofactors. Evidence for this specific ge... | |
medium_hidden_intermediate_09674 | Zika virus upregulates a gene that is enriched in non-classical monocytes. Evidence for this gene reports a log2 fold change of approximately 1.001 and an adjusted p-value of 0.03022. Which protein is encoded by this gene? | SID1 transmembrane family member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09674","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is enriched in non-classical monocytes. Evidence for this gene reports a log2 fold change... | |
medium_hidden_intermediate_09675 | Two genes are downregulated by Measles morbillivirus and participate in infectious disease. One of these genes has a reported log2 fold change of -1.223 and an adjusted p-value of 0.000798. Which cellular component is the location of this specific gene? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09675","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Measles morbillivirus and participate in infectious disease. One of these genes has a reporte... | |
medium_hidden_intermediate_09676 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in the response to oxidative stress. This specific gene exhibited a log2 fold change of approximately 7.96 and an adjusted p-value of 1.14e-05. Which protein is encoded by this gene? | Interactor protein for cytohesin exchange factors 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09676","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in ... | |
medium_hidden_intermediate_09677 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that participates in aerobic respiration and respiratory electron transport. This gene exhibited a log2 fold change of approximately -1.212 and an adjusted p-value of 0.02244. Which biological process is this... | pyruvate import into mitochondria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09677","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that partici... | |
medium_hidden_intermediate_09678 | Influenza A virus downregulates multiple genes that are located in the nucleus. One such gene exhibits a log2 fold change of -2.413 and an adjusted p-value of 1.663e-06. Which cell type is this gene enriched in? | intermediate monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09678","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus downregulates multiple genes that are located in the nucleus. One such gene exhibits a log2 fold change of... | |
medium_hidden_intermediate_09680 | In a study of Primate bocaparvovirus 1 infection, a gene is identified that is downregulated by the virus and involved in cilium assembly. Evidence for this specific gene reports a log2 fold change of -1.196 and an adjusted p-value of 0.007457. Which protein is encoded by this gene? | Trafficking protein particle complex subunit 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09680","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Primate bocaparvovirus 1 infection, a gene is identified that is downregulated by the virus and involved in ci... | |
medium_hidden_intermediate_09681 | A gene is upregulated by Primate bocaparvovirus 1 and is enriched in Regulatory T (Treg) cells. Experimental data for this gene reports a log2 fold change of 1.536 and an adjusted p-value of 0.03369. Which molecular function is enabled by this gene? | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09681","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is enriched in Regulatory T (Treg) cells. Experimental data for this g... | |
medium_hidden_intermediate_09684 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn participates in the process 'TP53 Regulates Metabolic Genes'. Evidence for this specific gene reports a log2 fold change of -1.368 and an adjusted p-value of 0.02084. Which... | Sestrin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09684","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_09685 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and participates in protein localization. Evidence for this gene reports a log2 fold change of -1.410 and an adjusted p-value of 7.527e-05. Which protein is encoded by this gene? | Peroxisomal leader peptide-processing protease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09685","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and particip... | |
medium_hidden_intermediate_09687 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the function of Chromatin modifying enzymes. Experimental data for this gene reports a log2 fold change of approximately 2.87 and an adjusted p-value of approximately 0.044. Which disease is associated with this gene? | spermatogenic failure, Y-linked, 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09687","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the function of Chromatin... | |
medium_hidden_intermediate_09688 | Vaccinia virus upregulates a gene that is associated with prostate cancer. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibited a log2 fold change of approximately 5.46 and an adjusted p-value of approximately 2.13e-12. Which protein is encoded by this gene? | Separin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09688","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that is associated with prostate cancer. In a study of cervical adenocarcinoma cell lines ... | |
medium_hidden_intermediate_09689 | Two genes are linked to Vaccinia virus via upregulation and to major depressive disorder via biomarker association. One of these genes exhibits a log2 fold change of 4.182 and an adjusted p-value of 7.819e-07 in cervical adenocarcinoma cell lines. Which cell type is enriched for this specific gene? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09689","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Vaccinia virus via upregulation and to major depressive disorder via biomarker association. One of t... | |
medium_hidden_intermediate_09690 | Two genes are structurally linked to Cardiovirus A via an upregulation relationship and to Regulatory T (Treg) cells via an enrichment relationship. One of these genes has a reported log2 fold change of 1.181 and an adjusted p-value of 0.01204 in a specific study. Which protein is encoded by this specific gene? | Hyaluronan and proteoglycan link protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09690","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via an upregulation relationship and to Regulatory T (Treg) cells via an ... | |
medium_hidden_intermediate_09692 | Zika virus upregulates a gene that is enriched in conventional dendritic cells. Evidence for this gene reports a log2 fold change of 1.621 and an adjusted p-value of 0.04089. Which protein is encoded by this gene? | Protein Smaug homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09692","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is enriched in conventional dendritic cells. Evidence for this gene reports a log2 fold c... | |
medium_hidden_intermediate_09693 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to the endosome via a 'located in' relationship. One of these genes has an associated expression profile showing a log2 fold change of -1.429 and an adjusted p-value of 0.005069. Which cell type is enriched for th... | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09693","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to the endosome v... | |
medium_hidden_intermediate_09694 | Vaccinia virus downregulates a specific gene that is involved in the regulation of cell population proliferation. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibited a log2 fold change of -1.694 and an adjusted p-value of 0.02633. Which disease is associated with genomic alterations in this... | autosomal recessive primary microcephaly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09694","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a specific gene that is involved in the regulation of cell population proliferation. In a study... | |
medium_hidden_intermediate_09696 | Zika virus downregulates a gene that is located in the mitochondrial matrix. Experimental data from glioma stem cells (study GSE114907) indicate that this specific gene has a log2 fold change of -1.130 and an adjusted p-value of 0.04645. Which disease is associated with this gene? | epsilon-trimethyllysine hydroxylase deficiency | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09696","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the mitochondrial matrix. Experimental data from glioma stem cells (study... | |
medium_hidden_intermediate_09697 | Hepacivirus C is reported to downregulate a gene that participates in mitochondrial protein degradation. Experimental data for one such gene shows a log2 fold change of -1.215 and an adjusted p-value of 0.000851. Which protein is encoded by this gene? | Cytochrome c oxidase subunit 5B, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09697","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that participates in mitochondrial protein degradation. Experimental data f... | |
medium_hidden_intermediate_09698 | Human alphaherpesvirus 1 upregulates a gene that is involved in the ERAD pathway. In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of 1.124 and an adjusted p-value of 0.03497. Which protein is encoded by this gene? | Transmembrane and ubiquitin-like domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09698","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is involved in the ERAD pathway. In a study of monocytic leukemia cell line... | |
medium_hidden_intermediate_09699 | In a study of Severe acute respiratory syndrome-related coronavirus infection, two genes are upregulated and subsequently found to bind RBM17. One of these genes exhibits a log2 fold change of 1.032 and an adjusted p-value of 1.472e-06. Which protein is encoded by the gene matching these statistical values? | THO complex subunit 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09699","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, two genes are upregulated and subsequently fo... | |
medium_hidden_intermediate_09701 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene that participates in the Cell Cycle. This gene exhibited a log2 fold change of approximately -1.66 and an adjusted p-value of 0.025. Which protein is encoded by this gene? | Kinetochore protein Spc24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09701","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_09702 | In a study of Hepacivirus C infection, a specific gene is downregulated and its expression is enriched in conventional dendritic cells. Evidence for this gene reports a log2 fold change of -1.257 and an adjusted p-value of 0.02383. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09702","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection, a specific gene is downregulated and its expression is enriched in conventional dendr... | |
medium_hidden_intermediate_09703 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene involved in cell-cell junction organization. This gene exhibited a log2 fold change of -1.471 and an adjusted p-value of 6.584e-13. Which protein is encoded by this gene? | InaD-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09703","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_09705 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes that are localized to the endosome. One such gene exhibited a log2 fold change of approximately 1.195 and an adjusted p-value of 0.01696. Which protein is encoded by this specific gene? | Flotillin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09705","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes that ... | |
medium_hidden_intermediate_09706 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in the G2/M cell cycle transition. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene exhibits a log2 fold change of approximately -1.857 and an adjusted p-value of 0.03557. Which p... | Protein phosphatase methylesterase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09706","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in the G2/M cell cycle transition. Exper... | |
medium_hidden_intermediate_09707 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Late SARS-CoV-2 Infection Events. Experimental evidence for this gene reports a log2 fold change of 2.454 and an adjusted p-value of 0.02634. Which molecular function is enabled by this gene? | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09707","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Late SARS-CoV-2 Infection... | |
medium_hidden_intermediate_09709 | In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), two genes are downregulated by the virus and both enable sulfotransferase activity. One of these genes exhibits a log2 fold change of approximately -1.147 and an adjusted p-value of 0.0332. Which protein is encoded by this specific... | Galactosylceramide sulfotransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09709","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), two genes are downregulated by the ... | |
medium_hidden_intermediate_09711 | Two genes are upregulated by Enterovirus A and enriched in natural killer cells. One of these genes shows a log2 fold change of 1.607 and an adjusted p-value of 0.006982 in rhabdomyosarcoma cells. Which disease is associated with this specific gene? | urinary bladder carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09711","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and enriched in natural killer cells. One of these genes shows a log2 fold change... | |
medium_hidden_intermediate_09712 | Hepacivirus C is reported to upregulate a specific gene, which is subsequently found to be enriched in non-classical monocytes. Experimental data for this gene indicates a log2 fold change of 1.771 and an adjusted p-value of 0.004555. Which disease is associated with this gene? | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09712","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a specific gene, which is subsequently found to be enriched in non-classical monocyt... | |
medium_hidden_intermediate_09713 | A gene expressed in germ cells interacts with PCNA. Experimental evidence indicates that this gene's protein product interacts with over 60 proteins, including those involved in DNA replication and repair such as MCM2, PCNA, ORC1, DNA polymerase delta, MSH-2, and DNA-dependent protein kinase. Which protein is encoded b... | Methylated-DNA--protein-cysteine methyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09713","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene expressed in germ cells interacts with PCNA. Experimental evidence indicates that this gene's protein product interac... | |
medium_hidden_intermediate_09714 | Human immunodeficiency virus 1 upregulates a gene that participates in O-linked glycosylation. Experimental data for this gene in macrophages (study GSE108897) show a log2 fold change of approximately 1.21 and an adjusted p-value of 0.00024. Which protein is encoded by this gene? | Beta-galactoside alpha-2,6-sialyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09714","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in O-linked glycosylation. Experimental data for this ge... | |
medium_hidden_intermediate_09715 | In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with the RBMX protein. One of these genes exhibits a log2 fold change of approximately 3.02 and an adjusted p-value of approximately 0.009. Which protein is encoded by this specific gene? | Roquin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09715","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with the R... | |
medium_hidden_intermediate_09716 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the clathrin-coated vesicle. Experimental data for this gene in lung cells shows a log2 fold change of approximately 1.035 and an adjusted p-value of 0.0001099. Which protein is encoded by this gene? | DENN domain-containing protein 1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09716","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the clathrin-coated vesicle. Exp... | |
medium_hidden_intermediate_09717 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in turn encodes a protein that binds to POLR2L. The expression data for this gene shows a log2 fold change of 1.095 and an adjusted p-value of 5.859e-05. Which protein is encoded by this gene? | General transcription factor 3C polypeptide 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09717","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in ... | |
medium_hidden_intermediate_09718 | Two genes are upregulated by Human alphaherpesvirus 1 and enriched in non-classical monocytes. One of these genes exhibits a log2 fold change of approximately 2.19 and an adjusted p-value of 0.0159 in a monocytic leukemia cell line. Which biological process is this specific gene involved in? | regulation of cell cycle | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09718","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 1 and enriched in non-classical monocytes. One of these genes exhibits a... | |
medium_hidden_intermediate_09719 | In a study of cervical adenocarcinoma cells (GSE11238), a gene is downregulated by Vaccinia virus and binds to NEDD8. This specific gene exhibits a log2 fold change of -1.664 and an adjusted p-value of 0.007058. Which biological process is this gene involved in? | epigenetic regulation of gene expression | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09719","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), a gene is downregulated by Vaccinia virus and binds to NEDD8. This s... | |
medium_hidden_intermediate_09722 | Two genes are structurally linked to Zika virus via downregulation and to WRN via binding. One of these genes has a reported log2 fold change of -1.456 and an adjusted p-value of 0.04107 in a specific study. Which disease is associated with this specific gene as a biomarker? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09722","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Zika virus via downregulation and to WRN via binding. One of these genes has a reported... | |
medium_hidden_intermediate_09723 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables L-glutamine transmembrane transporter activity. Evidence for one such gene reports a log2 fold change of 5.836 and an adjusted p-value of 0.0006892. Which protein is encoded by that gene? | Sodium-coupled neutral amino acid transporter 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09723","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables L-glutamine transmembrane transporter ... | |
medium_hidden_intermediate_09726 | A specific gene serves as a marker for Natural killer T (NKT) cells and is also identified as a biomarker for breast carcinoma. Evidence indicates that Quantitative RT-PCR demonstrated this gene, along with CXCL9, GNAI2, H2AFX, INDO, and MGC10986, was significantly differentially expressed in recurrence versus non-recu... | schistosomiasis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09726","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene serves as a marker for Natural killer T (NKT) cells and is also identified as a biomarker for breast carcino... | |
medium_hidden_intermediate_09727 | Human betaherpesvirus 5 is known to upregulate certain genes that participate in disease processes. One such gene exhibits a log2 fold change of 1.406 and an adjusted p-value of 2.252e-05 in foreskin fibroblast cell lines. Which disease is associated with this specific gene through genomic alterations? | Sialic acid storage disease, severe infantile type | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09727","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to upregulate certain genes that participate in disease processes. One such gene exhibits a... | |
medium_hidden_intermediate_09729 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to colitis via an 'associated with' relationship. One of these genes is reported in a study (GSE157852) involving choroid plexus epithelium, with a log2 fold change of approximately 4.23 and ... | Aquaporin-8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09729","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_09730 | Human immunodeficiency virus 1 downregulates a gene that is located in the late endosome. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately -1.072 and an adjusted p-value of 0.01672. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09730","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the late endosome. Evidence for this gene in macropha... | |
medium_hidden_intermediate_09732 | Zika virus downregulates a gene that participates in Signaling by TGFB family members. In glioma stem cells, this gene exhibits a log2 fold change of -2.701 and an adjusted p-value of 0.008461. Which protein is encoded by this gene? | SMAD family member 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09732","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Signaling by TGFB family members. In glioma stem cells, this gene exhib... | |
medium_hidden_intermediate_09733 | Hepacivirus C upregulates a gene that is involved in the innate immune response. Evidence for one such gene reports a log2 fold change of 1.172 and an adjusted p-value of 0.01714. Which molecular function is enabled by that gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09733","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the innate immune response. Evidence for one such gene reports a log2 f... | |
medium_hidden_intermediate_09734 | A gene is downregulated by Primate bocaparvovirus 1 and enriched in conventional dendritic cells. Evidence for this gene reports a log2 fold change of -1.033 and an adjusted p-value of 0.01351. Which disease is associated with this gene? | plasma cell myeloma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09734","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and enriched in conventional dendritic cells. Evidence for this gene rep... | |
medium_hidden_intermediate_09735 | Zika virus downregulates a gene that participates in protein ubiquitination. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this specific gene has a log2 fold change of approximately -1.54 and an adjusted p-value of 0.0076. Which protein is encoded by this gene? | Ubiquitin-conjugating enzyme E2 Q2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09735","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in protein ubiquitination. Transcriptomic data from glioma stem cells (stu... | |
medium_hidden_intermediate_09736 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables receptor tyrosine kinase binding. Experimental data for this gene shows a log2 fold change of 1.015 and an adjusted p-value of 0.01953. Which protein is encoded by this gene? | Growth factor receptor-bound protein 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09736","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables receptor tyrosine kinase binding.... | |
medium_hidden_intermediate_09737 | In a study of bronchial epithelial cells (GSE147507), Influenza A virus downregulates a gene that participates in protein metabolism. This specific gene exhibits a log2 fold change of -1.562 and an adjusted p-value of 6.145e-05. What molecular function is enabled by this gene? | arylsulfatase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09737","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells (GSE147507), Influenza A virus downregulates a gene that participates in protein me... | |
medium_hidden_intermediate_09738 | A gene serves as a marker for CD4+ T cells and is enriched in basophils. Evidence for one such gene reports a mean expression of 36.90 TPM, a z-score of 2.33, and a fold enrichment of 4.90. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09738","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for CD4+ T cells and is enriched in basophils. Evidence for one such gene reports a mean expressio... | |
medium_hidden_intermediate_09739 | Zika virus downregulates a gene that participates in the metabolism of amino acids and derivatives. Evidence for this gene reports a log2 fold change of -1.967 and an adjusted p-value of 0.006357. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09739","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the metabolism of amino acids and derivatives. Evidence for this gene r... | |
medium_hidden_intermediate_09740 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate a specific gene that participates in Viral Infection Pathways. This gene exhibited a log2 fold change of approximately 1.12 and an adjusted p-value of approximately 0.0002. Which biological process is this gene involved ... | spermatogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09740","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate a specific gene that par... | |
medium_hidden_intermediate_09741 | Severe acute respiratory syndrome-related coronavirus downregulates a specific gene that participates in MAPK family signaling cascades. Experimental data for this gene in lung cells shows a log2 fold change of -2.080 and an adjusted p-value of 0.0004015. Which biological process is this gene involved in? | myeloid cell differentiation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09741","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a specific gene that participates in MAPK family signali... | |
medium_hidden_intermediate_09743 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in substantia nigra development. One of these genes exhibits a log2 fold change of 1.704 and an adjusted p-value of 6.988e-09 in a specific study. Which cellular component is the location of this specific gene? | NLRP1 inflammasome complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09743","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in substantia nigra deve... | |
medium_hidden_intermediate_09744 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), a gene is identified as being upregulated by Influenza A virus and serving as a biomarker for breast cancer. This specific gene exhibits a log2 fold change of approximately 1.049 and an adjusted p-value of 2.576e-07. Which protein is encoded by th... | Ubiquitin-associated and SH3 domain-containing protein B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09744","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), a gene is identified as being upregulated by Influe... | |
medium_hidden_intermediate_09746 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to uveal melanoma via association. One of these genes exhibits a log2 fold change of -2.579 and an adjusted p-value of 0.004393 in a specific study. Which protein is encoded by the gene matching these statistical values... | Growth arrest-specific protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09746","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to uveal melanoma via a... | |
medium_hidden_intermediate_09747 | A gene is upregulated by Vaccinia virus and interacts with CLPP. Experimental data for this gene in a cervical adenocarcinoma cell line shows a log2 fold change of approximately 3.07 and an adjusted p-value of approximately 3.67e-09. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09747","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and interacts with CLPP. Experimental data for this gene in a cervical adenocarcinom... | |
medium_hidden_intermediate_09748 | Measles morbillivirus upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Evidence for one such gene reports a log2 fold change of 3.493 and an adjusted p-value of 0.03994. Which protein is encoded by that gene? | Cell migration-inducing and hyaluronan-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09748","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. ... | |
medium_hidden_intermediate_09750 | A gene is upregulated by Primate bocaparvovirus 1 and is involved in the negative regulation of viral genome replication. Experimental evidence for this gene shows a log2 fold change of 2.453 and an adjusted p-value of 0.008502. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09750","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is involved in the negative regulation of viral genome replication. Ex... | |
medium_hidden_intermediate_09752 | Human immunodeficiency virus 1 is reported to downregulate a specific gene, which is in turn enriched in naive B cells. Experimental data for this gene in macrophages (from study GSE108897) shows a log2 fold change of -2.945 and an adjusted p-value of 0.01941. Which protein is encoded by this gene? | Neuronal membrane glycoprotein M6-a | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09752","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 is reported to downregulate a specific gene, which is in turn enriched in naive B cells. Expe... | |
medium_hidden_intermediate_09753 | Cardiovirus A downregulates a gene that is involved in the positive regulation of DNA-templated transcription. Experimental data from a cervical adenocarcinoma cell line (study GSE122967) indicates that this specific gene has a log2 fold change of approximately -1.192 and an adjusted p-value of 0.03125. Which protein i... | Swi5-dependent recombination DNA repair protein 1 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09753","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that is involved in the positive regulation of DNA-templated transcription. Experimental ... | |
medium_hidden_intermediate_09755 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are both associated with pituitary gigantism. One of these genes exhibits a log2 fold change of -1.322 and an adjusted p-value of 0.007343 in lung tissue data from study GSE148697. Which disease is linked to this specific gene thro... | atrial septal defect | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09755","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are both associated with pituitary ... | |
medium_hidden_intermediate_09756 | Two genes are downregulated by Hepacivirus C and enriched in conventional dendritic cells. One of these genes exhibits a log2 fold change of approximately -1.875 and an adjusted p-value of 0.04419 in peripheral blood mononuclear cells. What molecular function is enabled by this specific gene? | tubulin binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09756","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Hepacivirus C and enriched in conventional dendritic cells. One of these genes exhibits a log... | |
medium_hidden_intermediate_09757 | Human immunodeficiency virus 1 upregulates a gene that is involved in protein ubiquitination. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of 1.037 and an adjusted p-value of 0.02603. Which protein does this specific gene interact with? | MMS19 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09757","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in protein ubiquitination. In a study of macrophages (GSE... | |
medium_hidden_intermediate_09758 | Human alphaherpesvirus 1 is known to downregulate a gene that participates in the function of the TWIK-related acid-sensitive K+ channel (TASK). In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibited a log2 fold change of -1.393 and an adjusted p-value of 0.007184. Which protein is encoded by ... | Potassium channel subfamily K member 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09758","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is known to downregulate a gene that participates in the function of the TWIK-related acid-sensitiv... | |
medium_hidden_intermediate_09759 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with hepatocellular carcinoma. One of these genes exhibits a log2 fold change of -2.601 and an adjusted p-value of 0.00293 in a specific study. What molecular function is enabled by this specific gene? | sequence-specific double-stranded DNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09759","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with hepatocellular ... | |
medium_hidden_intermediate_09760 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables GTPase activity. Evidence for one such gene reports a log2 fold change of 1.318 and an adjusted p-value of 0.007077. Which cellular component is that gene located in? | cytoplasmic vesicle membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09760","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables GTPase activity. Evidence for one such... |
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