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medium_hidden_intermediate_09761 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with NCOR1. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.367 and an adjusted p-value of 0.001033. Which protein is encoded by this ge... | Transcription factor ETV6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09761","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with NCOR1. Experimental data for this inte... | |
medium_hidden_intermediate_09763 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the nuclear pore. One of these genes exhibits a log2 fold change of 1.225 and an adjusted p-value of 0.02629 in a specific study. Which biological process is this specific gene involved in? | tRNA export from nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09763","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the nuclear pore. One ... | |
medium_hidden_intermediate_09765 | Zika virus downregulates a gene that interacts with SNAP29. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.436 and an adjusted p-value of 0.02871. Which protein is encoded by this gene? | EH domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09765","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with SNAP29. In a study of glioma stem cells (GSE114907), one such gene exhib... | |
medium_hidden_intermediate_09767 | Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to Gamma delta(γδ) T cells via an enrichment relationship. One of these genes is associated with a specific dataset entry reporting a log2 fold change of 1.369 and an adjusted p-value of 0.0009953. Which protein is ... | Zinc finger protein 266 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09767","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to Gamma delta(γδ) ... | |
medium_hidden_intermediate_09768 | Vaccinia virus upregulates a gene that enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene showed a log2 fold change of 1.131 and an adjusted p-value of 0.001527. Which disease is associated with this gene as a biomarker? | bipolar disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09768","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. In a study of cervical ... | |
medium_hidden_intermediate_09771 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to NOTCH2 via an 'interacts with' relationship. One of these genes is reported in a study (GSE108897) with a log2 fold change of approximately -2.001 and an adjusted p-value of approximately 0.0089. Which cell typ... | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09771","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to NOTCH2 via an ... | |
medium_hidden_intermediate_09772 | Human respirovirus 3 downregulates a gene that enables protein binding. Evidence for this gene in non-small cell lung adenocarcinoma cell lines (study GSE147507) reports a log2 fold change of -1.269 and an adjusted p-value of 0.04844. Which disease is associated with this gene through genomic alterations? | autism spectrum disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09772","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human respirovirus 3 downregulates a gene that enables protein binding. Evidence for this gene in non-small cell lung adenoc... | |
medium_hidden_intermediate_09773 | Human alphaherpesvirus 3 is known to downregulate a specific gene that is enriched in eosinophils. In a study of melanoma cell lines (GSE136586), this gene exhibited a log2 fold change of -1.367 and an adjusted p-value of 0.0002459. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09773","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is known to downregulate a specific gene that is enriched in eosinophils. In a study of melanoma ce... | |
medium_hidden_intermediate_09774 | Rhinovirus A infection leads to the downregulation of certain genes whose products are located in the extracellular space. One such gene exhibits a log2 fold change of approximately -1.58 and an adjusted p-value of 0.0026 in cytotoxic T-lymphocytes. What molecular function is enabled by the protein product of this spec... | RNA nuclease activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09774","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain genes whose products are located in the extracellular space. O... | |
medium_hidden_intermediate_09775 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is downregulated and enables receptor ligand activity. Evidence for this gene reports a log2 fold change of -4.018 and an adjusted p-value of 0.004225. Which disease is associated with this gene? | chronic rhinosinusitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09775","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is downregulat... | |
medium_hidden_intermediate_09777 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the CDP-diacylglycerol biosynthetic process. Evidence for this specific gene reports a log2 fold change of 1.351 and an adjusted p-value of 0.004043. Which protein is encoded by this gene? | Phosphatidate cytidylyltransferase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09777","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the CDP-diacylglycerol biosynth... | |
medium_hidden_intermediate_09779 | Zika virus infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to SEPT7. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.658 and an adjusted p-value of 0.009677. Which protein is encoded by this gene? | Mitogen-activated protein kinase 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09779","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to SEPT7. In... | |
medium_hidden_intermediate_09780 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables cadherin binding. Experimental data for this gene in lung cells shows a log2 fold change of approximately -1.000 and an adjusted p-value of 0.01825. Which protein is encoded by this gene? | Testin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09780","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables cadherin binding. Experimental data ... | |
medium_hidden_intermediate_09781 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for colorectal carcinoma. Transcriptomic data for this gene in choroid plexus epithelium (study GSE157852) reports a log2 fold change of approximately 1.23 and an adjusted p-value of approximately 0.00042. What mole... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09781","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for colorectal carc... | |
medium_hidden_intermediate_09782 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and enabling nucleoside triphosphate adenylate kinase activity was found to have a log2 fold change of 1.573 and an adjusted p-value of 1.215e-09. Which disease is associated with this specific gene? | trisomy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09782","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and enabling nucleoside tr... | |
medium_hidden_intermediate_09783 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of DNA-templated transcription. Experimental data for this gene, derived from peripheral blood mononuclear cells in study GSE131504, indicates a log2 fold change of approximately -1.30 and an adjusted p-va... | lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09783","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of DNA-te... | |
medium_hidden_intermediate_09784 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene located in chromatin. This specific gene exhibited a log2 fold change of approximately -1.018 and an adjusted p-value of 0.00431. Which protein does this gene interact with? | CDC7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09784","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_09785 | Two genes are upregulated by Human alphaherpesvirus 3 and enriched in basophils. One of these genes exhibits a log2 fold change of 1.512 and an adjusted p-value of 1.185e-06 in a melanoma cell line study. Which cellular component is the location of this specific gene? | early endosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09785","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 3 and enriched in basophils. One of these genes exhibits a log2 fold cha... | |
medium_hidden_intermediate_09786 | Pegivirus C is reported to downregulate a specific gene, which in turn is associated with a protein-containing complex. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene exhibits a log2 fold change of approximately -1.96 and an adjusted p-value of 0.0027. Which pr... | Exportin-6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09786","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn is associated with a protein-containing complex. Expe... | |
medium_hidden_intermediate_09787 | In a study of vascular endothelial cells (GSE16354), a gene is downregulated by Human gammaherpesvirus 8 and its protein product binds to UBB. This gene exhibits a log2 fold change of approximately -1.85 and an adjusted p-value of 0.021. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase RNF144B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09787","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of vascular endothelial cells (GSE16354), a gene is downregulated by Human gammaherpesvirus 8 and its protein pro... | |
medium_hidden_intermediate_09788 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to refractory malignant neoplasm via an 'associated with' relationship. One of these genes has a reported log2 fold change of -2.832 and an adjusted p-value of 0.0002383 in lung tissue data.... | Cytidine deaminase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09788","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_09791 | Zika virus downregulates a specific gene that is located in the cell cortex. Experimental data for this gene in glioma stem cells reports a log2 fold change of approximately -1.04 and an adjusted p-value of 0.02375. In which cell type is this gene enriched? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09791","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is located in the cell cortex. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_09792 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in aerobic respiration and respiratory electron transport. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibited a log2 fold change of approximately -1.80 and an adjusted p-value of 0.0494. Which protein is encoded ... | NADP-dependent malic enzyme | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09792","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in aerobic respiration and respiratory electron... | |
medium_hidden_intermediate_09793 | A gene is upregulated by Hepacivirus C and enriched in regulatory T (Treg) cells. Experimental data for this gene in hepatocytes from study GSE132606 reports a log2 fold change of 1.133 and an adjusted p-value of 0.005751. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09793","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and enriched in regulatory T (Treg) cells. Experimental data for this gene in hepatoc... | |
medium_hidden_intermediate_09794 | Human alphaherpesvirus 1 upregulates a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for one such gene reports a log2 fold change of 1.998 and an adjusted p-value of 0.008952. Which protein is encoded by that gene? | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09794","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for one... | |
medium_hidden_intermediate_09795 | In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and serving as a biomarker for schizophrenia. This specific gene exhibits a log2 fold change of approximately -1.77 and an adjusted p-value of approximately 0.0147. Which protein is encoded by this gene? | Coiled-coil domain-containing protein 86 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09795","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and ser... | |
medium_hidden_intermediate_09796 | Identify the gene that serves as a marker for monocytes and is located in the mitochondrion. Contextual evidence indicates this gene encodes a component of the translocase of the outer mitochondrial membrane (TOM) complex involved in preprotein import. Which disease is associated with this gene via a biomarker relation... | Ischemic stroke | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09796","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Identify the gene that serves as a marker for monocytes and is located in the mitochondrion. Contextual evidence indicates t... | |
medium_hidden_intermediate_09800 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with MAP3K14. One of these genes exhibits a log2 fold change of approximately -1.14 and an adjusted p-value of 0.004006 in SAEC cells. Which protein is encoded by this specific gene? | E3 ubiquitin-protein ligase ZFP91 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09800","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with MAP3K14. One of these... | |
medium_hidden_intermediate_09802 | Pegivirus C is reported to downregulate a gene whose protein product is located in the lysosomal membrane. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of -1.330 and an adjusted p-value of 0.00186. Which protein is encoded by this gene? | Lysosomal dipeptide transporter MFSD1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09802","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene whose protein product is located in the lysosomal membrane. In a study of per... | |
medium_hidden_intermediate_09803 | Benzatropine and Homatropine are both known to interact with a specific intermediate drug. Evidence indicates that 2% homatropine hydrobromide eyedrops effectively antagonize the actions of this intermediate drug. Which disease is this intermediate drug indicated for? | glaucoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09803","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Benzatropine and Homatropine are both known to interact with a specific intermediate drug. Evidence indicates that 2% homatr... | |
medium_hidden_intermediate_09804 | Human betaherpesvirus 5 is known to downregulate a specific gene that is involved in the positive regulation of the MAPK cascade. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE111036) show a log2 fold change of -2.421 and an adjusted p-value of 0.0288. Which disease is associated with... | major affective disorder 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09804","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate a specific gene that is involved in the positive regulation of the MAPK cas... | |
medium_hidden_intermediate_09806 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with leukemia. Experimental data for this gene reports a log2 fold change of approximately 1.324 and an adjusted p-value of 0.006505. Which disease is linked to this gene through genomic alterations? | coronary artery disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09806","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with leukemia. Experimental... | |
medium_hidden_intermediate_09807 | Zika virus downregulates a gene that interacts with TTC4. In glioma stem cells, one such gene exhibits a log2 fold change of -2.305 and an adjusted p-value of 0.02152. Which protein is encoded by this gene? | Co-chaperone protein HGH1 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09807","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with TTC4. In glioma stem cells, one such gene exhibits a log2 fold change of... | |
medium_hidden_intermediate_09808 | Measles morbillivirus upregulates a gene that is involved in the positive regulation of cell population proliferation. In a study of pleural mesothelioma cells (GSE117668), one such gene exhibited a log2 fold change of 3.855 and an adjusted p-value of 0.04696. Which protein is encoded by this gene? | C-X-C motif chemokine 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09808","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the positive regulation of cell population proliferation. In a ... | |
medium_hidden_intermediate_09809 | Measles morbillivirus upregulates a gene that interacts with CANX. Evidence for one such gene reports a log2 fold change of 1.284 and an adjusted p-value of 0.002689. Which protein is encoded by that gene? | FAD-dependent oxidoreductase domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09809","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with CANX. Evidence for one such gene reports a log2 fold change of ... | |
medium_hidden_intermediate_09810 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the TNFR2 non-canonical NF-kB pathway. One of these genes shows a log2 fold change of 1.941 and an adjusted p-value of 0.01958 in bronchial epithelial cells. Which disease is associated with this specific gene as a bio... | Schwartz-Jampel syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09810","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the TNFR2 non-canonica... | |
medium_hidden_intermediate_09812 | Hepacivirus C upregulates a gene that participates in Viral Infection Pathways. Evidence for this gene in hepatocytes (study GSE132606) reports a log2 fold change of 1.484 and an adjusted p-value of 0.001756. Which cellular component is this gene located in? | trans-Golgi network membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09812","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in Viral Infection Pathways. Evidence for this gene in hepatocytes (study... | |
medium_hidden_intermediate_09813 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and its product is located in the Golgi membrane. This gene exhibits a log2 fold change of 1.574 and an adjusted p-value of 7.202e-06. Which protein is encoded by this gene? | UDP-sugar transporter protein SLC35A5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09813","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and its product is ... | |
medium_hidden_intermediate_09814 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with the VCP protein. This gene exhibited a log2 fold change of approximately 2.21 and an adjusted p-value of 0.007871. Which protein is encoded by this gene? | Ankyrin repeat domain-containing protein 13B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09814","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_09817 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in immunoregulatory interactions between a lymphoid and a non-lymphoid cell. Evidence for one such gene reports a log2 fold change of -1.249 and an adjusted p-value of 0.008029. Which molecular function is enabled by that gene? | carbohydrate binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09817","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in immunoregulatory interaction... | |
medium_hidden_intermediate_09818 | Rift Valley fever phlebovirus upregulates a gene that is enriched in natural killer cells. Evidence for one such gene reports a log2 fold change of 1.527 and an adjusted p-value of 0.0009826. Which protein does this gene interact with? | BTRC | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09818","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that is enriched in natural killer cells. Evidence for one such gene report... | |
medium_hidden_intermediate_09819 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes involved in the synthesis of Prostaglandins (PG) and Thromboxanes (TX). One such gene exhibited a log2 fold change of 1.683 and an adjusted p-value of 0.01506. Which protein is encoded by this spe... | Prostaglandin reductase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09819","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_09823 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with SOCS6. This gene exhibited a log2 fold change of 3.775 and an adjusted p-value of 1.655e-06. Which biological process is this gene involved in? | protein insertion into mitochondrial inner membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09823","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, wh... | |
medium_hidden_intermediate_09824 | Two genes are structurally linked to Enterovirus A via an upregulation relationship and to the positive regulation of cold-induced thermogenesis via an involvement relationship. One of these genes exhibits a log2 fold change of 2.563 and an adjusted p-value of 0.00464 in rhabdomyosarcoma cells. Which disease is associa... | ulcerative colitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09824","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via an upregulation relationship and to the positive regulation of cold-i... | |
medium_hidden_intermediate_09826 | Hepacivirus C upregulates a gene that is located in the ubiquitin ligase complex. Evidence for one such gene reports a log2 fold change of 1.168 and an adjusted p-value of 0.01773. Which protein is encoded by that gene? | LIM domain only protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09826","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is located in the ubiquitin ligase complex. Evidence for one such gene reports a log2 ... | |
medium_hidden_intermediate_09828 | Hepacivirus C is reported to downregulate a gene that is involved in the immune response. Experimental data for this gene shows a log2 fold change of -1.156 and an adjusted p-value of 0.003195. In which cell type is this gene enriched? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09828","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is involved in the immune response. Experimental data for this gene sh... | |
medium_hidden_intermediate_09829 | A gene is upregulated by Measles morbillivirus and enables DNA binding. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of approximately 2.706 and an adjusted p-value of 0.000379. Which disease is associated with this gene? | arthritic joint disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09829","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and enables DNA binding. Experimental data for this gene in pleural mesotheli... | |
medium_hidden_intermediate_09830 | Zaire ebolavirus upregulates a gene that is associated with gastric adenocarcinoma. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of 1.163 and an adjusted p-value of 8.343e-05. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase TRIM31 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09830","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is associated with gastric adenocarcinoma. In a study of retinal pigment epithelium... | |
medium_hidden_intermediate_09831 | Human immunodeficiency virus 1 upregulates a gene that participates in the CDC42 GTPase cycle. Evidence for this gene reports a log2 fold change of 1.402 and an adjusted p-value of 0.0343. Which protein is encoded by this gene? | Cdc42 effector protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09831","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the CDC42 GTPase cycle. Evidence for this gene report... | |
medium_hidden_intermediate_09832 | Human mastadenovirus C downregulates a gene that subsequently binds to MRPS28. Experimental data for this intermediate gene in lung fibroblast cell lines (study GSE120891) reports a log2 fold change of approximately -1.42 and an adjusted p-value of approximately 0.046. Which protein is encoded by this intermediate gene... | Large ribosomal subunit protein uL1m | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09832","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human mastadenovirus C downregulates a gene that subsequently binds to MRPS28. Experimental data for this intermediate gene ... | |
medium_hidden_intermediate_09833 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate a specific gene involved in the regulation of transcription by RNA polymerase II. This gene exhibited a log2 fold change of 1.175 and an adjusted p-value of 1.646e-10. Which disease is associated... | myocardial infarction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09833","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_09835 | Cardiovirus A is reported to downregulate a gene that enables protein-macromolecule adaptor activity. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibits a log2 fold change of approximately -1.018 and an adjusted p-value of 0.02645. Which protein is encoded by this specific gene? | RNA-binding protein 33 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09835","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A is reported to downregulate a gene that enables protein-macromolecule adaptor activity. In a study of cervical... | |
medium_hidden_intermediate_09836 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to melanoma via association. One of these genes was reported in a study (GSE148729) using a lung adenocarcinoma cell line, showing a log2 fold change of approximately 3.336 and an adjusted p-value of 4.2e-10. Which protei... | DNA-binding protein inhibitor ID-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09836","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to melanoma via associati... | |
medium_hidden_intermediate_09837 | Two genes are structurally linked from Hepacivirus C via an upregulation relationship and onward to neuroblastoma via an association relationship. One of these genes is reported in a study (GSE132606) with a log2 fold change of approximately 1.256 and an adjusted p-value of approximately 0.0028. Which disease is connec... | chronic periodontitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09837","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Hepacivirus C via an upregulation relationship and onward to neuroblastoma via an ass... | |
medium_hidden_intermediate_09838 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Keratan sulfate biosynthesis. One of these genes exhibits a log2 fold change of -1.727 and an adjusted p-value of 4.357e-05 in a specific study. Which biological process is this specific gene involved in? | lactosylceramide biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09838","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Keratan sulfate bios... | |
medium_hidden_intermediate_09839 | Two genes are upregulated by Enterovirus A and are both associated with seminoma. One of these genes exhibits a log2 fold change of 1.470 and an adjusted p-value of 0.03875 in rhabdomyosarcoma cells. Which disease is linked to this specific gene through genomic alterations? | cervical carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09839","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and are both associated with seminoma. One of these genes exhibits a log2 fold ch... | |
medium_hidden_intermediate_09840 | In a study of colonic adenocarcinoma cells (GSE148729), Severe acute respiratory syndrome-related coronavirus upregulates a gene that subsequently binds to WAPL. One such gene exhibits a log2 fold change of 1.542 and an adjusted p-value of 0.04172. Which biological process is this specific gene involved in? | nucleocytoplasmic transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09840","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of colonic adenocarcinoma cells (GSE148729), Severe acute respiratory syndrome-related coronavirus upregulates a ... | |
medium_hidden_intermediate_09841 | A gene is upregulated by Enterovirus A and enriched in Regulatory T (Treg) cells. Evidence for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of 2.746 and an adjusted p-value of 0.006517. Which cellular component is this gene located in? | transcription repressor complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09841","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Enterovirus A and enriched in Regulatory T (Treg) cells. Evidence for this gene in rhabdomyosarcoma... | |
medium_hidden_intermediate_09843 | In a study of cardiomyocyte cell lines, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables DNA-binding transcription factor activity, RNA polymerase II-specific. Evidence for this gene reports a log2 fold change of approximately 1.38 and an adjusted p-value of approximately 0.04.... | Transcription factor COE4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09843","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and e... | |
medium_hidden_intermediate_09844 | Zika virus downregulates a gene that is involved in the negative regulation of the cell cycle. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.337 and an adjusted p-value of 0.01114. Which protein interacts with this specific gene? | MRM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09844","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the negative regulation of the cell cycle. In a study of glioma stem cel... | |
medium_hidden_intermediate_09846 | Zika virus upregulates a specific gene that is involved in protein phosphorylation. Transcriptomic data from neural stem cells (study GSE129180) indicates this gene has a log2 fold change of approximately 1.99 and an adjusted p-value of 0.0387. Which disease is causally linked to this gene? | polyploidy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09846","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene that is involved in protein phosphorylation. Transcriptomic data from neural stem cel... | |
medium_hidden_intermediate_09847 | A gene serves as a marker for microglial cells and is enriched in intermediate monocytes. Evidence for one such gene reports a mean expression of 7.94 TPM, a z-score of 2.84, and a fold enrichment of 13.86. Which disease is associated with this gene through genomic alterations? | microphthalmia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09847","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for microglial cells and is enriched in intermediate monocytes. Evidence for one such gene reports... | |
medium_hidden_intermediate_09848 | Two genes are downregulated by Human immunodeficiency virus 1 and are located in caveola. One of these genes exhibits a log2 fold change of -1.641 and an adjusted p-value of 5.432e-06 in macrophages (study GSE108897). Which disease is associated with this specific gene as a biomarker? | benign neoplasm of large intestine | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09848","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and are located in caveola. One of these genes exhibits a log2... | |
medium_hidden_intermediate_09850 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specific gene, which in turn interacts with PPP1CA. This gene exhibits a log2 fold change of 6.770 and an adjusted p-value of 2.524e-09. Which protein is encoded by this upregulated gene? | Cell division cycle-associated protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09850","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specifi... | |
medium_hidden_intermediate_09851 | Hepacivirus C upregulates a gene that participates in the Innate Immune System. Evidence for one such gene reports a log2 fold change of 4.747 and an adjusted p-value of 0.02119. Which disease is associated with that gene? | follicular lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09851","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the Innate Immune System. Evidence for one such gene reports a log2 fo... | |
medium_hidden_intermediate_09854 | Hepacivirus C is associated with the downregulation of a specific gene, which is in turn enriched in Memory CD8+ T cells. Experimental data for this gene reports a log2 fold change of -1.593 and an adjusted p-value of 0.002433. Which protein is encoded by this gene? | Copine-7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09854","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a specific gene, which is in turn enriched in Memory CD8+ T cells. Ex... | |
medium_hidden_intermediate_09855 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with diabetes mellitus. Experimental data for this gene reports a log2 fold change of 1.382 and an adjusted p-value of 0.04949. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09855","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with diabetes mellitus. Exp... | |
medium_hidden_intermediate_09856 | Human immunodeficiency virus 1 downregulates a gene that is involved in chemical synaptic transmission. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately -1.49 and an adjusted p-value of 0.026. Which protein is encoded by this specific gene? | G-protein coupled receptor 176 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09856","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in chemical synaptic transmission. In a study of macrop... | |
medium_hidden_intermediate_09857 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn encodes a protein that binds to PTPRF. The upregulation of this gene is characterized by a log2 fold change of approximately 2.44 and an adjusted p-value of 1... | Liprin-alpha-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09857","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upre... | |
medium_hidden_intermediate_09858 | Human betaherpesvirus 5 is linked to hepatocellular carcinoma via a gene that acts as a biomarker for the cancer and is downregulated by the virus. One such gene exhibits a log2 fold change of -1.755 and an adjusted p-value of 0.001407 in foreskin fibroblast cell lines. Which protein is encoded by this specific gene? | Tissue factor pathway inhibitor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09858","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to hepatocellular carcinoma via a gene that acts as a biomarker for the cancer and is down... | |
medium_hidden_intermediate_09859 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of cell migration. Evidence for one such gene reports a log2 fold change of approximately 1.16 and an adjusted p-value of approximately 5.45e-05. In which cell type is this specific gene enriched? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09859","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of cell... | |
medium_hidden_intermediate_09862 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to VAPA via a 'binds' relationship. One of these genes has an associated expression profile showing a log2 fold change of approximately 1.02 and an adjusted p-value of 0.007099. Which protein... | Golgi to ER traffic protein 4 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09862","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_09863 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Selenoamino acid metabolism. One of these genes exhibits a log2 fold change of 1.315 and an adjusted p-value of 2.35e-05 in a specific study. Which cellular component is the location of this specific gene? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09863","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Selenoamino acid metab... | |
medium_hidden_intermediate_09864 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate multiple genes involved in vesicle-mediated transport. One such gene exhibited a log2 fold change of approximately 1.387 and an adjusted p-value of 6.294e-07. What molecular function is enabled by this specific gene... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09864","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate multiple genes invo... | |
medium_hidden_intermediate_09865 | Hepacivirus C is reported to upregulate a specific gene, which is subsequently found to be enriched in conventional dendritic cells. Experimental data for this gene indicates a log2 fold change of approximately 1.19 and an adjusted p-value of 8.11e-05. Which disease is associated with this gene as a biomarker? | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09865","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a specific gene, which is subsequently found to be enriched in conventional dendriti... | |
medium_hidden_intermediate_09866 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enriched in Memory CD4+ T cells. Evidence for this gene reports a log2 fold change of 1.457 and an adjusted p-value of 0.01963. Which biological process is this gene involved in? | signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09866","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enriched in Memory CD4+ T cells. Evidence... | |
medium_hidden_intermediate_09867 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the metabolism of fat-soluble vitamins. Evidence for this gene reports a log2 fold change of -1.065 and an adjusted p-value of 0.000121. Which disease is connected to this gene through genomic alterations? | familial isolated deficiency of vitamin E | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09867","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the metabolism of fat-s... | |
medium_hidden_intermediate_09868 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated by the virus and known to bind NCK1. This gene exhibits a log2 fold change of approximately 2.36 and an adjusted p-value of 6.80e-08. Which biological process is this gene involved in? | Arp2/3 complex-mediated actin nucleation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09868","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated by the virus and kn... | |
medium_hidden_intermediate_09872 | Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and associated with glioma. One of these genes exhibits a log2 fold change of -1.627 and an adjusted p-value of 0.0314 in a specific study. Which disease is linked to this specific gene via a biomarker relationship? | alveolar rhabdomyosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09872","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and associated with glioma. One of... | |
medium_hidden_intermediate_09873 | Two genes are structurally linked from Pegivirus C via a 'downregulates' relationship and subsequently to NAD(P)H oxidase H2O2-forming activity via an 'enables' relationship. One of these genes exhibits a log2 fold change of -2.223 and an adjusted p-value of 0.01736 in peripheral blood mononuclear cells (study GSE13150... | cutaneous melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09873","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Pegivirus C via a 'downregulates' relationship and subsequently to NAD(P)H oxidase H2... | |
medium_hidden_intermediate_09874 | Measles morbillivirus upregulates a gene that interacts with LMNA. One such gene exhibits a log2 fold change of 1.070 and an adjusted p-value of 0.002831. Which protein is encoded by this gene? | Sentrin-specific protease 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09874","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with LMNA. One such gene exhibits a log2 fold change of 1.070 and an... | |
medium_hidden_intermediate_09875 | In a study of cytotoxic T-lymphocytes (GSE106475), Human orthopneumovirus infection was found to upregulate a specific gene, which in turn enables protein binding. This gene exhibited a log2 fold change of 1.177 and an adjusted p-value of 0.03705. Which protein is encoded by this gene? | ADP-ribosylation factor-like protein 4D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09875","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cytotoxic T-lymphocytes (GSE106475), Human orthopneumovirus infection was found to upregulate a specific gene,... | |
medium_hidden_intermediate_09876 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable DNA-binding transcription activator activity, RNA polymerase II-specific. One of these genes was reported in a study of bronchial epithelial cells (GSE147507) with a log2 fold change of approximately 1.01 and an adjusted ... | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09876","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable DNA-binding transcription... | |
medium_hidden_intermediate_09878 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with VPS35. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) shows a log2 fold change of -1.788 and an adjusted p-value of 0.0001853. What is the protein encoded by this gene? | Ganglioside-induced differentiation-associated protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09878","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with VPS35. Experimental data for this gene... | |
medium_hidden_intermediate_09879 | Zika virus downregulates a specific gene that is enriched in conventional dendritic cells. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.01 and an adjusted p-value of 0.009253. Which protein is encoded by this gene? | Oxysterol-binding protein-related protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09879","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is enriched in conventional dendritic cells. Experimental data for this gene i... | |
medium_hidden_intermediate_09881 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the epigenetic regulation of gene expression by MLL3 and MLL4 complexes. Evidence for this gene reports a log2 fold change of 2.259 and an adjusted p-value of 0.0103. Which disease is connected to this gene through genomi... | prostate carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09881","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the epigenetic regulation... | |
medium_hidden_intermediate_09882 | In a study of pancreatic cell lines (GSE151803), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which in turn is associated with electron transfer activity. Evidence for this gene reports a log2 fold change of -1.151 and an adjusted p-value of 0.01466. Which protein is ... | Alcohol dehydrogenase class-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09882","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pancreatic cell lines (GSE151803), Severe acute respiratory syndrome-related coronavirus was found to downregu... | |
medium_hidden_intermediate_09884 | Human alphaherpesvirus 1 upregulates a gene that participates in the Immune System. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibited a log2 fold change of 3.607 and an adjusted p-value of 0.03276. Which protein does this specific gene bind to? | SERPINB13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09884","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in the Immune System. In a study of monocytic leukemia cell li... | |
medium_hidden_intermediate_09885 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in pyrimidine salvage. Evidence for this gene reports a log2 fold change of 3.828 and an adjusted p-value of 0.004368. Which protein does this gene product interact with? | VIM | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09885","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in pyrimidine salvage. Evidence f... | |
medium_hidden_intermediate_09886 | Two genes are structurally linked from Cardiovirus A to Conventional dendritic cell via a 'downregulates' relationship followed by an 'enriched in' relationship. One of these genes has an associated expression profile in cervical adenocarcinoma cell lines (study GSE122967) showing a log2 fold change of -1.245 and an ad... | Plasma membrane ascorbate-dependent reductase CYBRD1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09886","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Cardiovirus A to Conventional dendritic cell via a 'downregulates' relationship follo... | |
medium_hidden_intermediate_09887 | Human betaherpesvirus 5 is known to upregulate certain genes that are subsequently associated with glioma. One such gene exhibits a log2 fold change of 2.359 and an adjusted p-value of 0.04605 in a specific study. Which disease is linked to this gene via a biomarker relationship? | coronary artery disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09887","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to upregulate certain genes that are subsequently associated with glioma. One such gene exh... | |
medium_hidden_intermediate_09888 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in mitochondrial translation termination. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene has a log2 fold change of -1.282 and an adjusted p-value of 0.0006781. Which protein is ... | NADH-ubiquinone oxidoreductase chain 4L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09888","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in mitochondrial translation termination... | |
medium_hidden_intermediate_09889 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes involved in the positive regulation of translation. One such gene exhibited a log2 fold change of 1.662 and an adjusted p-value of 2.595e-12. Which protein is encoded by this specific gene? | La-related protein 4B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09889","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_09890 | Severe acute respiratory syndrome-related coronavirus is reported to downregulate multiple genes involved in the L-aspartate catabolic process. One such gene exhibits a log2 fold change of -1.013 and an adjusted p-value of 9.648e-05 in a specific study. Which protein is encoded by this gene? | Aspartate aminotransferase, cytoplasmic | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09890","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is reported to downregulate multiple genes involved in the L-aspartate... | |
medium_hidden_intermediate_09891 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and enable protein-lysine N-methyltransferase activity. One of these genes was reported in a study with a log2 fold change of approximately 1.185 and an adjusted p-value of 0.04652. Which protein is encoded by this specific gene? | EEF1A lysine methyltransferase 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09891","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and enable protein-lysine N-methyltransfe... | |
medium_hidden_intermediate_09892 | Hepacivirus C is associated with the downregulation of a specific gene, which is subsequently found to be enriched in Regulatory T (Treg) cells. Experimental data for this gene indicates a log2 fold change of -1.355 and an adjusted p-value of 0.001448. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09892","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a specific gene, which is subsequently found to be enriched in Regula... | |
medium_hidden_intermediate_09893 | Zika virus upregulates a gene that is enriched in basophils. Evidence for this gene reports a log2 fold change of approximately 3.20 and an adjusted p-value of 0.0036. Which molecular function is enabled by this gene? | hydroxyacid-oxoacid transhydrogenase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09893","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is enriched in basophils. Evidence for this gene reports a log2 fold change of approximat... | |
medium_hidden_intermediate_09896 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and associated with leukopenia via genomic alterations. This specific gene exhibits a log2 fold change of approximately 1.078 and an adjusted p-value of 0.0005152. Which protein is encoded by this gene? | GTP-binding protein Di-Ras1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09896","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and associated with leukopeni... | |
medium_hidden_intermediate_09897 | In a study of lung cells (GSE148697), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene that enables microtubule binding. One such gene exhibited a log2 fold change of -1.445 and an adjusted p-value of 8.441e-07. Which protein is encoded by this specific gene? | ADP-ribosylation factor-like protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09897","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells (GSE148697), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene... | |
medium_hidden_intermediate_09898 | Rhinovirus A infection is associated with the upregulation of specific genes that are enriched in basophils. One such gene exhibits a log2 fold change of approximately 1.62 and an adjusted p-value of approximately 0.029 in cytotoxic T-lymphocytes. Which protein is encoded by this gene? | Popeye domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09898","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the upregulation of specific genes that are enriched in basophils. One such gene e... |
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