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medium_convergence_00527 | RAB32 and RAB38 are both localized to a specific cellular compartment. Experimental evidence indicates that silencing the BLOC-3 subunits Hps1 and Hps4 causes the mislocalization of RAB32 and RAB38, accompanied by a reduction in pigmentation. Based on this evidence, which specific sub-compartment (connected via a 'part... | chitosome | Medium | convergence | {"qa_id":"medium_convergence_00527","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAB32 and RAB38 are both localized to a specific cellular compartment. Experimental evidence indicates that silencing the BLOC-3 subunits Hps1 and Hps4 cause... | |
medium_convergence_00528 | Both Hepacivirus C and Zaire ebolavirus are known to upregulate a specific gene. Experimental data for this gene indicates a log2 fold change of approximately 1.21 and an adjusted p-value of 5.067e-07. Which biological process is this gene involved in? | T cell mediated immunity | Medium | convergence | {"qa_id":"medium_convergence_00528","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Zaire ebolavirus are known to upregulate a specific gene. Experimental data for this gene indicates a log2 fold change of approximatel... | |
medium_convergence_00529 | CSF2RA and DMBT1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We have shown that soluble gp-340 binds a surfactant protein A family member in a calcium-dependent manner independent of the lectin activity of that protein.' Which biological process is this shared entity inv... | opsonization | Medium | convergence | {"qa_id":"medium_convergence_00529","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSF2RA and DMBT1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We have shown that soluble gp-340 binds a surfa... | |
medium_convergence_00530 | Both Human betaherpesvirus 5 and Zaire ebolavirus are associated with the downregulation of a specific host gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately -1.38 and an adjusted p-value of 0.038. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase TRIM65 | Medium | convergence | {"qa_id":"medium_convergence_00530","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Zaire ebolavirus are associated with the downregulation of a specific host gene. Experimental data for this gene in foreskin... | |
medium_convergence_00531 | YWHAQ and RAB4A share common interaction partners. One such partner is described by the evidence: 'We have identified a novel 80-kDa protein that interacts specifically with the GTP-bound conformation of Rab4, and subsequent work has shown that it also interacts strongly with Rab11.' Which protein is encoded by the gen... | Rab11 family-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00531","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and RAB4A share common interaction partners. One such partner is described by the evidence: 'We have identified a novel 80-kDa protein that interacts s... | |
medium_convergence_00532 | ESR1 and HDAC3 both interact with a shared protein partner. Evidence regarding one such partner states: 'A protein-protein interaction assay indicated that the full-length ER binds to this partner in vitro.' Which protein is encoded by the gene corresponding to this shared partner? | Nuclear receptor corepressor 2 | Medium | convergence | {"qa_id":"medium_convergence_00532","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HDAC3 both interact with a shared protein partner. Evidence regarding one such partner states: 'A protein-protein interaction assay indicated that t... | |
medium_convergence_00533 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gene was found to have a log2 fold change of approximately 3.047 and an adjusted p-value of 0.00698. Which protein does this gene product interact with? | SOCS6 | Medium | convergence | {"qa_id":"medium_convergence_00533","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gene... | |
medium_convergence_00534 | Rift Valley fever phlebovirus and Rhinovirus A both upregulate a specific gene. Evidence for this shared target in SAEC cells (study GSE102481) reports a log2 fold change of approximately 2.84 and an adjusted p-value of 0.0205. Which protein is encoded by this gene? | Interferon beta | Medium | convergence | {"qa_id":"medium_convergence_00534","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Rhinovirus A both upregulate a specific gene. Evidence for this shared target in SAEC cells (study GSE102481) reports a log... | |
medium_convergence_00535 | Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of approximately -1.68 and an adjusted p-value of 0.0042. Which disease is associated with this gene? | epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome | Medium | convergence | {"qa_id":"medium_convergence_00535","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE13208... | |
medium_convergence_00536 | CXCL10 and CCL5 are both involved in the same biological process. Evidence indicates that inhibiting the recruitment of monocytes during the early phase of metastasis via a receptor antagonist for one of these chemokines significantly reduces tumor cell survival and attenuates metastasis. Which biological process, conn... | monocyte chemotaxis | Medium | convergence | {"qa_id":"medium_convergence_00536","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CXCL10 and CCL5 are both involved in the same biological process. Evidence indicates that inhibiting the recruitment of monocytes during the early phase of m... | |
medium_convergence_00537 | AGO4 and AGO1 each share a binding partner with another gene. Evidence concerning one such shared entity states: 'Here, we show that the N-terminal GW-repeat-containing regions of all three TNRC6s interact with the four human Argonaute proteins (AGO1-AGO4).' Which cell type is that shared entity enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_00537","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AGO4 and AGO1 each share a binding partner with another gene. Evidence concerning one such shared entity states: 'Here, we show that the N-terminal GW-repeat... | |
medium_convergence_00538 | HSPA1A and HSPA8 both interact with a specific gene product. Experimental evidence regarding this shared interaction partner states: 'Analyses of the cotransporter immunoprecipitates revealed that it formed complexes with the core chaperones Hsp90, Hsp70, and Hsp40.' Which protein is encoded by this shared interaction ... | Solute carrier family 12 member 3 | Medium | convergence | {"qa_id":"medium_convergence_00538","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA1A and HSPA8 both interact with a specific gene product. Experimental evidence regarding this shared interaction partner states: 'Analyses of the cotrans... | |
medium_convergence_00539 | The facial nucleus and the pontine raphe nucleus share a common anatomical classification. Evidence regarding one of these shared entities describes it as 'The group of motor neurons residing in the pons that innervate the muscles of facial expression.' Which larger anatomical structure is this shared entity a part of? | brainstem | Medium | convergence | {"qa_id":"medium_convergence_00539","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The facial nucleus and the pontine raphe nucleus share a common anatomical classification. Evidence regarding one of these shared entities describes it as 'T... | |
medium_convergence_00541 | HDAC5 and JUN both interact with a specific shared protein. Contextual evidence states: 'We then demonstrate that [REDACTED] associates in vitro not only with class I HDACs but also with class II enzymes such as HDAC5.' Which protein is encoded by the gene corresponding to this shared entity? | Nuclear receptor-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00541","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC5 and JUN both interact with a specific shared protein. Contextual evidence states: 'We then demonstrate that [REDACTED] associates in vitro not only wit... | |
medium_convergence_00542 | BIRC2 and CD14 share multiple binding partners. One shared partner is part of a cIAP1/cIAP2/TRAF2 E3 ligase complex that binds to and ubiquitinates IKKε. Which disease is associated with this shared partner via a biomarker relationship? | major depressive disorder | Medium | convergence | {"qa_id":"medium_convergence_00542","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and CD14 share multiple binding partners. One shared partner is part of a cIAP1/cIAP2/TRAF2 E3 ligase complex that binds to and ubiquitinates IKKε. Whi... | |
medium_convergence_00543 | CTNNB1 and HDAC1 share multiple binding partners. One shared partner is associated with evidence stating: 'A subset of these mutations also cause a decreased interaction with the HDAC1-associated proteins RbAp48 and mSin3A.' Which protein is encoded by this shared partner? | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_00543","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and HDAC1 share multiple binding partners. One shared partner is associated with evidence stating: 'A subset of these mutations also cause a decreased... | |
medium_convergence_00544 | ATF2 and CREBBP each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Phosphorylation of this entity induced its interaction with the transcriptional co-activator cAMP-response element binding protein-binding protein.' Which protein is connected to that entity through the 'enc... | Interferon regulatory factor 3 | Medium | convergence | {"qa_id":"medium_convergence_00544","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATF2 and CREBBP each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Phosphorylation of this entity induced its i... | |
medium_convergence_00545 | EP300 and ARID1A each interact with more than one shared gene. Evidence concerning one shared entity reports that Coimmunoprecipitation analyses of endogenous proteins demonstrate an association of IRF-3 with the transcriptional coactivators CBP and p300 only subsequent to infection. Which disease is connected to that ... | arteriosclerosis disorder | Medium | convergence | {"qa_id":"medium_convergence_00545","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and ARID1A each interact with more than one shared gene. Evidence concerning one shared entity reports that Coimmunoprecipitation analyses of endogenou... | |
medium_convergence_00546 | KRT16 and KRT18 each interact with a shared keratin partner. Evidence regarding one such partner states: 'We measured interactions between two different keratin pairs and we confirm the findings that K6+K17 form very stable heterodimers whereas the shared partner+K18 interactions were weaker.' Which disease is associat... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00546","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRT16 and KRT18 each interact with a shared keratin partner. Evidence regarding one such partner states: 'We measured interactions between two different kera... | |
medium_convergence_00547 | Human immunodeficiency virus 1 and Pegivirus C both upregulate a specific gene. Evidence for this shared target indicates a log2 fold change of approximately 1.43 and an adjusted p-value of 0.000352. Which protein is encoded by this gene? | UBA-like domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00547","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human immunodeficiency virus 1 and Pegivirus C both upregulate a specific gene. Evidence for this shared target indicates a log2 fold change of approximately... | |
medium_convergence_00548 | EP300 and KMT2D both interact with a shared protein. Evidence indicates that this protein associates with histone-modifying enzymatic complexes, specifically the MLL2 histone methyltransferase (HMT) and STAGA histone acetyltransferase (HAT) complexes, to facilitate their interaction with β-catenin and to augment Wnt1-i... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_00548","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and KMT2D both interact with a shared protein. Evidence indicates that this protein associates with histone-modifying enzymatic complexes, specifically... | |
medium_convergence_00549 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 1.28 and an adjusted p-value of 0.00029. Which protein is encoded by this gene? | Glutathione hydrolase 1 proenzyme | Medium | convergence | {"qa_id":"medium_convergence_00549","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a lo... | |
medium_convergence_00550 | UHRF2 and EP300 both interact with a shared protein. Evidence regarding one such shared entity states: 'Here, we show that the ubiquitin ligase NIRF (also known as UHRF2), which induces G1 arrest, interacts with multiple cell cycle proteins including cyclins (A2, B1, D1 and E1), p53 and pRB, and ubiquitinates cyclins D... | G1/S-specific cyclin-D1 | Medium | convergence | {"qa_id":"medium_convergence_00550","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UHRF2 and EP300 both interact with a shared protein. Evidence regarding one such shared entity states: 'Here, we show that the ubiquitin ligase NIRF (also kn... | |
medium_convergence_00551 | BMP2 and BMP5 both interact with a specific receptor. Evidence regarding this receptor states: 'Using antibody-mediated immunofluorescence copatching of epitope-tagged receptors, we provide evidence in live cells for preexisting heteromeric (BR-II/BR-Ia and BR-II/BR-Ib) and homomeric (BR-II/BR-II, BR-Ia/ BR-Ia, BR-Ib/ ... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00551","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP2 and BMP5 both interact with a specific receptor. Evidence regarding this receptor states: 'Using antibody-mediated immunofluorescence copatching of epit... | |
medium_convergence_00552 | HDAC6 and CREBBP share multiple interacting partners. One such partner is a substrate of MST1/2 and a co-activator of LATS1/2 within the canonical Hippo pathway. This entity is acetylated at lysine 11 by the acetyltransferase CBP and deacetylated by HDAC6. Which disease is associated with this entity as a biomarker? | obesity disorder | Medium | convergence | {"qa_id":"medium_convergence_00552","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and CREBBP share multiple interacting partners. One such partner is a substrate of MST1/2 and a co-activator of LATS1/2 within the canonical Hippo path... | |
medium_convergence_00553 | PPARG and PSMC5 both interact with a specific shared protein. Evidence indicates that PPARγ physically associates with this protein in human breast cancer cells and that its signaling is linked to PPARγ. Which protein is encoded by this shared entity? | Vitamin D3 receptor | Medium | convergence | {"qa_id":"medium_convergence_00553","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPARG and PSMC5 both interact with a specific shared protein. Evidence indicates that PPARγ physically associates with this protein in human breast cancer ce... | |
medium_convergence_00554 | Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.250 and an adjusted p-value of 0.004664. Which biological process is this gene involved in? | substantia nigra development | Medium | convergence | {"qa_id":"medium_convergence_00554","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114... | |
medium_convergence_00555 | STUB1 and GSK3B both interact with a shared protein. Evidence regarding this shared protein states: 'These observations demonstrate the direct interaction between the shared protein and CHIP and this interaction requires conformational change of the shared protein by heat stress.' Which protein is encoded by this share... | Heat shock factor protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00555","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and GSK3B both interact with a shared protein. Evidence regarding this shared protein states: 'These observations demonstrate the direct interaction be... | |
medium_convergence_00557 | LIN54 and LIN37 both interact with a shared protein complex component. Evidence regarding this component states: 'Using an integrated approach combining proteomics, genomics, and bioinformatic analyses, we identified a p130 complex termed DP, RB-like, E2F, and MuvB (DREAM) that contains mammalian homologs of synMuvB pr... | Protein lin-9 homolog | Medium | convergence | {"qa_id":"medium_convergence_00557","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LIN54 and LIN37 both interact with a shared protein complex component. Evidence regarding this component states: 'Using an integrated approach combining prot... | |
medium_convergence_00558 | The bundle of His and the right bundle branch are both classified as types of a specific cardiac anatomy. Evidence regarding this shared anatomical category describes it as a part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers. What is the broader tissue type to which ... | cardiac muscle tissue | Medium | convergence | {"qa_id":"medium_convergence_00558","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The bundle of His and the right bundle branch are both classified as types of a specific cardiac anatomy. Evidence regarding this shared anatomical category ... | |
medium_convergence_00559 | Morphine and Metformin share a common interacting drug. Evidence indicates that isobolographic analyses revealed synergistic interaction between peripheral morphine and this shared entity in the formalin test. Which disease is this entity indicated for? | bipolar I disorder | Medium | convergence | {"qa_id":"medium_convergence_00559","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Metformin share a common interacting drug. Evidence indicates that isobolographic analyses revealed synergistic interaction between peripheral m... | |
medium_convergence_00560 | CHD4 and CHEK1 share multiple interacting partners. One such partner is described in the following context: 'We discovered that DNMTs and the core components of the NuRD (Mi-2/nucleosome remodeling and deacetylase) nucleosome remodeling complex, chromo domain helicase DNA-binding protein 4 (CHD4) and histone deacetylas... | DNA (cytosine-5)-methyltransferase 1 | Medium | convergence | {"qa_id":"medium_convergence_00560","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and CHEK1 share multiple interacting partners. One such partner is described in the following context: 'We discovered that DNMTs and the core components... | |
medium_convergence_00561 | Both EGF and EGFR are reported to bind to a specific shared protein entity. Contextual evidence indicates that a fragment of this entity, specifically residues 44-86, exhibits high binding affinity to the EGFR receptor, similar to human EGF. Which protein is encoded by this shared entity? | Proheparin-binding EGF-like growth factor | Medium | convergence | {"qa_id":"medium_convergence_00561","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both EGF and EGFR are reported to bind to a specific shared protein entity. Contextual evidence indicates that a fragment of this entity, specifically residu... | |
medium_convergence_00562 | DYRK1A and MYC both interact with a shared gene product. Evidence indicates that upregulation of this shared entity increases its binding with c-Myc and activates c-Myc, which in turn induces the expression of CCND1/CDK4, promoting glioma cell temozolomide resistance and proliferation. Which cell type is this entity en... | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_00562","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DYRK1A and MYC both interact with a shared gene product. Evidence indicates that upregulation of this shared entity increases its binding with c-Myc and acti... | |
medium_convergence_00563 | Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that this gene has a log2 fold change of approximately -3.51 and an adjusted p-value of approximately 0.0049. Which protein is encoded by this gene? | Rhophilin-1 | Medium | convergence | {"qa_id":"medium_convergence_00563","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that ... | |
medium_convergence_00564 | IRAK1 and MAP3K7 (TAK1) both interact with a shared adaptor protein. Evidence indicates that this adaptor functions within a complex containing TAK1, TAB1, and either the adaptor itself or TAB3. Which protein is encoded by the gene corresponding to this shared adaptor? | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00564","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRAK1 and MAP3K7 (TAK1) both interact with a shared adaptor protein. Evidence indicates that this adaptor functions within a complex containing TAK1, TAB1, a... | |
medium_convergence_00565 | CCDC47 and VCP share interactions with multiple common partners. One such partner is involved in a process where its interaction with valosin-containing protein (p97/VCP) is crucial for the retrotranslocation of polyubiquitinated substrates in the ERAD pathway. Which protein is encoded by this specific shared partner? | Rhomboid-related protein 4 | Medium | convergence | {"qa_id":"medium_convergence_00565","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCDC47 and VCP share interactions with multiple common partners. One such partner is involved in a process where its interaction with valosin-containing prot... | |
medium_convergence_00566 | BRD4 and HECTD1 both interact with a shared protein. Evidence for one such shared partner indicates that in vitro analysis showed it binds directly to the largest subunit, RFC-140, thereby interacting with the entire RFC complex. Which protein is encoded by this shared partner? | Replication factor C subunit 3 | Medium | convergence | {"qa_id":"medium_convergence_00566","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and HECTD1 both interact with a shared protein. Evidence for one such shared partner indicates that in vitro analysis showed it binds directly to the la... | |
medium_convergence_00568 | AKT1 and ESR1 share multiple interacting partners. One such partner is identified in the following evidence: 'Here we show that a human homologue of the DAF16 transcription factor in Caenorhabditis elegans, is rapidly phosphorylated by human protein kinase Balpha (PKBalpha) at Thr-24, Ser-256, and Ser-319 in vitro and ... | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | convergence | {"qa_id":"medium_convergence_00568","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and ESR1 share multiple interacting partners. One such partner is identified in the following evidence: 'Here we show that a human homologue of the DAF1... | |
medium_convergence_00569 | GRB2 and IL3 both interact with a shared protein entity. Evidence regarding this entity states: 'We show here that human IL-3 induces heterodimerization of IL-3R alpha and beta c and that disulfide linkage of these chains is involved in receptor activation but not high-affinity binding.' Which protein is encoded by the... | Interleukin-3 receptor subunit alpha | Medium | convergence | {"qa_id":"medium_convergence_00569","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and IL3 both interact with a shared protein entity. Evidence regarding this entity states: 'We show here that human IL-3 induces heterodimerization of I... | |
medium_convergence_00570 | CTCF and MDM2 share interaction partners. One such shared partner is distinguished by evidence stating: 'We found that this protein, but not RPS19, binds to the central acidic domain of MDM2, similar to RPL5 and RPL23, and inhibits its E3 ubiquitin ligase activity toward p53.' Which protein is encoded by this specific ... | Small ribosomal subunit protein uS11 | Medium | convergence | {"qa_id":"medium_convergence_00570","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTCF and MDM2 share interaction partners. One such shared partner is distinguished by evidence stating: 'We found that this protein, but not RPS19, binds to ... | |
medium_convergence_00571 | TOPBP1 and E2F1 share multiple interacting partners. One such shared partner is involved in a process where a protein encoded by this partner interacts with and recruits topoisomerase-binding protein 1 (TOPBP1), a key activator of ATR signaling, to sites of DNA damage. Which protein is encoded by this shared partner? | Microcephalin | Medium | convergence | {"qa_id":"medium_convergence_00571","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and E2F1 share multiple interacting partners. One such shared partner is involved in a process where a protein encoded by this partner interacts with ... | |
medium_convergence_00572 | EP300 and LEF1 share multiple binding partners. One such partner is described in the following evidence: 'Here we show the interaction between the basic helix-loop-helix and leucine-zipper region of this transcription factor and LEF-1.' Which disease is associated with this transcription factor via a biomarker relation... | acute monocytic leukemia | Medium | convergence | {"qa_id":"medium_convergence_00572","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and LEF1 share multiple binding partners. One such partner is described in the following evidence: 'Here we show the interaction between the basic heli... | |
medium_convergence_00574 | MCM3 and CDC6 both interact with a specific shared protein. Evidence indicates that this shared protein binds strongly to ORC1 and ORC2. Which protein is encoded by the gene corresponding to this shared entity? | DNA replication licensing factor MCM7 | Medium | convergence | {"qa_id":"medium_convergence_00574","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM3 and CDC6 both interact with a specific shared protein. Evidence indicates that this shared protein binds strongly to ORC1 and ORC2. Which protein is enc... | |
medium_convergence_00575 | Hepacivirus C and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in hepatocytes shows a log2 fold change of -1.213 and an adjusted p-value of 0.01314. Which protein is encoded by this gene? | Plasma protease C1 inhibitor | Medium | convergence | {"qa_id":"medium_convergence_00575","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in hepatocytes shows a log2 fold change of -1.213 and an ad... | |
medium_convergence_00576 | Both West Nile virus and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. In a study of monocyte-derived dendritic cells (GSE136342), evidence for one such shared entity reports a log2 fold change of 1.264 and an adjusted p-value of 0.01457. Which protein is encoded by that specific gene? | Ubiquitin-like protein ISG15 | Medium | convergence | {"qa_id":"medium_convergence_00576","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. In a study of monocyte-derived dendritic cells (GSE136... | |
medium_convergence_00577 | CTNNB1 and HLTF both interact with a specific transcription factor. Experimental evidence indicates that when endogenous Smad7 is repressed by specific small interfering RNA, the TGF-beta-induced increase in activated p38, Akt phosphorylated on Ser473, and glycogen synthase kinase 3beta phosphorylated on Ser9 is preven... | Lymphoid enhancer-binding factor 1 | Medium | convergence | {"qa_id":"medium_convergence_00577","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and HLTF both interact with a specific transcription factor. Experimental evidence indicates that when endogenous Smad7 is repressed by specific small... | |
medium_convergence_00578 | SEC61B and VCP share multiple interacting partners. One such partner is known to associate directly with p97 via its UBX domain. Which cellular component is this specific partner located in? | endoplasmic reticulum membrane | Medium | convergence | {"qa_id":"medium_convergence_00578","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SEC61B and VCP share multiple interacting partners. One such partner is known to associate directly with p97 via its UBX domain. Which cellular component is ... | |
medium_convergence_00579 | Both Measles morbillivirus and Dengue virus are known to downregulate a specific gene. Experimental data for this gene, derived from pleural mesothelioma cells, reports a log2 fold change of -2.681 and an adjusted p-value of 2.926e-05. Which cellular component is this gene located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_00579","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Dengue virus are known to downregulate a specific gene. Experimental data for this gene, derived from pleural mesothelioma cel... | |
medium_convergence_00580 | SFN and PLK1 both interact with a shared protein. Evidence indicates that the association between PLK1 and this shared protein is an essential event in the degradation of the shared protein during an unperturbed cell cycle. Which cellular component is this shared protein located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00580","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SFN and PLK1 both interact with a shared protein. Evidence indicates that the association between PLK1 and this shared protein is an essential event in the d... | |
medium_convergence_00582 | TANK and TBK1 share binding partners. One such shared partner is associated with the N-terminal region of a TIR domain-containing adapter molecule and is linked to TBK1, a kinase of IFN regulatory factor-3 (an essential transcription factor for IFN-beta expression). Which protein is encoded by this shared partner? | TIR domain-containing adapter molecule 1 | Medium | convergence | {"qa_id":"medium_convergence_00582","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TANK and TBK1 share binding partners. One such shared partner is associated with the N-terminal region of a TIR domain-containing adapter molecule and is lin... | |
medium_convergence_00583 | MATK and BRAF each interact with more than one shared entity. Evidence concerning one shared entity reports that CHK was found to be associated with tyrosine-phosphorylated receptors encoded by that entity in PC12 cells upon stimulation with nerve growth factor. Which protein is encoded by that entity? | High affinity nerve growth factor receptor | Medium | convergence | {"qa_id":"medium_convergence_00583","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MATK and BRAF each interact with more than one shared entity. Evidence concerning one shared entity reports that CHK was found to be associated with tyrosine... | |
medium_convergence_00585 | RC3H1 and PSPC1 both interact with a shared protein. Evidence indicates that this shared protein binds directly and with high affinity to Roquin, a interaction that stabilizes the protein within cells. Which gene encodes this shared protein? | FMR1-interacting protein NUFIP2 | Medium | convergence | {"qa_id":"medium_convergence_00585","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RC3H1 and PSPC1 both interact with a shared protein. Evidence indicates that this shared protein binds directly and with high affinity to Roquin, a interacti... | |
medium_convergence_00586 | COPS5 and EGFR share a common interacting partner. Experimental evidence indicates that this partner colocalizes and directly interacts with Jab1, as demonstrated by fluorescence resonance energy transfer and co-immunoprecipitation studies. Which disease is associated with this shared partner through genomic alteration... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00586","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and EGFR share a common interacting partner. Experimental evidence indicates that this partner colocalizes and directly interacts with Jab1, as demonst... | |
medium_convergence_00587 | KDM1A and RCOR1 share multiple interaction partners. One such partner is implicated in a context where LSD1 interacts with a nuclear receptor directly through its SWIRM and amine oxidase domains. Which disease is associated with this specific shared partner? | acute lymphoblastic leukemia | Medium | convergence | {"qa_id":"medium_convergence_00587","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KDM1A and RCOR1 share multiple interaction partners. One such partner is implicated in a context where LSD1 interacts with a nuclear receptor directly throug... | |
medium_convergence_00588 | ERCC2 and ERCC3 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Protein affinity assays demonstrate that TFIIE binds directly to ERCC-3, a DNA repair protein associated with TFIIH.' Which disease is connected to that entity through an association? | trichothiodystrophy 6, nonphotosensitive | Medium | convergence | {"qa_id":"medium_convergence_00588","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC2 and ERCC3 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Protein affinity assays demonstrate ... | |
medium_convergence_00589 | Both Orthohepevirus A and Zika virus downregulate a specific gene in hepatocytes, as reported in study GSE135619. For one such shared target, the observed log2 fold change is -1.391 and the adjusted p-value is 0.04032. Which protein interacts with this specific gene product? | PTPN6 | Medium | convergence | {"qa_id":"medium_convergence_00589","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Zika virus downregulate a specific gene in hepatocytes, as reported in study GSE135619. For one such shared target, the observed lo... | |
medium_convergence_00590 | RAD51 and BRIP1 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'In this study, we report a specific interaction between this protein and BACH1/FANCJ, a DNA helicase involved in the repair of DNA crosslinks.' Which protein is encoded by this shared interaction partner? | DNA topoisomerase 2-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00590","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51 and BRIP1 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'In this study, we report a specific intera... | |
medium_convergence_00591 | NTRK1 and PRKN (Parkin) share multiple interacting partners. One such shared partner is described in the following evidence: 'Here, we show that bcl-2-associated athanogene 5, a BAG family member, directly interacts with parkin and the chaperone Hsp70.' Which protein product is encoded by this shared partner? | BAG family molecular chaperone regulator 5 | Medium | convergence | {"qa_id":"medium_convergence_00591","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NTRK1 and PRKN (Parkin) share multiple interacting partners. One such shared partner is described in the following evidence: 'Here, we show that bcl-2-associ... | |
medium_convergence_00592 | Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of -2.636 and an adjusted p-value of 0.003649. Which disease is associated with this gene as a biomarker? | ovarian cancer | Medium | convergence | {"qa_id":"medium_convergence_00592","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific gene. Experimental data for this gene in macrophages (from stud... | |
medium_convergence_00593 | YAP1 and AR share multiple interacting partners. One such partner is a subunit of the SWI/SNF chromatin remodeling complex, which has been shown to display hormone-dependent interactions with the androgen receptor (AR) through its FxxFF motif. Which disease is associated with this specific shared partner via a biomarke... | intellectual disability | Medium | convergence | {"qa_id":"medium_convergence_00593","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and AR share multiple interacting partners. One such partner is a subunit of the SWI/SNF chromatin remodeling complex, which has been shown to display h... | |
medium_convergence_00594 | BMI1 and HIST1H4A share multiple binding partners. One such shared partner is reported to coimmunoprecipitate and cofractionate with HPH1 and a polyhomeotic protein homolog. Which cell type is enriched for this specific shared partner? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_00594","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMI1 and HIST1H4A share multiple binding partners. One such shared partner is reported to coimmunoprecipitate and cofractionate with HPH1 and a polyhomeotic ... | |
medium_convergence_00595 | Both Rift Valley fever phlebovirus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately 3.598 and an adjusted p-value of 0.004436. In which cell type is this gene enriched? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_00595","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Rift Valley fever phlebovirus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold ch... | |
medium_convergence_00596 | CRK and ITK both interact with a shared protein. Evidence regarding one such shared entity states: 'Third, the Itk Src homology (SH3) 3 and SH2 domains interact cooperatively with Syk-phosphorylated [the shared protein].' Which protein is encoded by the gene corresponding to this shared entity? | Lymphocyte cytosolic protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00596","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and ITK both interact with a shared protein. Evidence regarding one such shared entity states: 'Third, the Itk Src homology (SH3) 3 and SH2 domains inter... | |
medium_convergence_00597 | Human gammaherpesvirus 4 and Measles morbillivirus both downregulate a specific gene. Experimental data for this gene in gamma delta T-lymphocytes (from study GSE13906) shows a log2 fold change of approximately -1.09 and an adjusted p-value of 0.0224. Which protein is encoded by this gene? | Fatty acid-binding protein, heart | Medium | convergence | {"qa_id":"medium_convergence_00597","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human gammaherpesvirus 4 and Measles morbillivirus both downregulate a specific gene. Experimental data for this gene in gamma delta T-lymphocytes (from stud... | |
medium_convergence_00598 | ARPC5 and ACTR2 both interact with a shared protein partner. Evidence indicates that the NTA region of this partner interacts directly with the Arp2/3 complex, as demonstrated by affinity chromatography, immunoprecipitation assays, and binding assays using purified components. Which disease is associated with this prot... | esophageal squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00598","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC5 and ACTR2 both interact with a shared protein partner. Evidence indicates that the NTA region of this partner interacts directly with the Arp2/3 comple... | |
medium_convergence_00599 | RPA2 and SKP1 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Purification of a UvrD DNA helicase, identified a physical interaction with replication protein A (RPA), the major cellular single-stranded DNA (ssDNA)-binding protein complex.' Which protein is encoded b... | F-box DNA helicase 1 | Medium | convergence | {"qa_id":"medium_convergence_00599","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPA2 and SKP1 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Purification of a UvrD DNA helicase, iden... | |
medium_convergence_00600 | CUL4A and CCNH each interact with more than one shared protein. Evidence concerning one shared entity reports that the UV-DDB complex consists of DDB1 and this entity, and it is a component of the cullin 4A (CUL4A)-based ubiquitin ligase, DDB1-CUL4A(this entity). Which cell type is enriched with that entity? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_00600","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL4A and CCNH each interact with more than one shared protein. Evidence concerning one shared entity reports that the UV-DDB complex consists of DDB1 and th... | |
medium_convergence_00602 | ERBB3 and ERBB4 share binding partners. One such shared partner is described in evidence stating: 'Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases.' Which protein is encoded by the gene corresponding to this shared binding partner? | Pro-neuregulin-2, membrane-bound isoform | Medium | convergence | {"qa_id":"medium_convergence_00602","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB3 and ERBB4 share binding partners. One such shared partner is described in evidence stating: 'Like NRG-1, the EGF-like domain of the new ligands binds t... | |
medium_convergence_00604 | Peginterferon alfa-2a and Interferon beta-1b both interact with a specific antiretroviral drug. Clinical evidence indicates that treating hepatitis C increases the risk of lactic acidosis associated with this drug. What condition is this drug indicated for? | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_00604","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Peginterferon alfa-2a and Interferon beta-1b both interact with a specific antiretroviral drug. Clinical evidence indicates that treating hepatitis C increas... | |
medium_convergence_00606 | GATA4 and GATA6 are both involved in a shared biological process. Evidence regarding one such shared process states: 'Our data demonstrate the key role of GATA4 in human testicular development.' Which anatomical structure is the result of the development governed by this specific biological process? | testis | Medium | convergence | {"qa_id":"medium_convergence_00606","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA4 and GATA6 are both involved in a shared biological process. Evidence regarding one such shared process states: 'Our data demonstrate the key role of GA... | |
medium_convergence_00607 | CENPA and CDC42 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we show that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (CENP-M, CENP-N and a shared protein), along with... | short stature and microcephaly with genital anomalies | Medium | convergence | {"qa_id":"medium_convergence_00607","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CDC42 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we show that CENP-A nucleosomes direct... | |
medium_convergence_00608 | INSIG1 and SP1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In sterol-treated cells, the SCAP/SREBP complex binds to Insig-1 or Insig-2, which retains the complex in the ER, blocking SREBP processing and decreasing lipid synthesis.' Which protein is connected to that ... | Sterol regulatory element-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00608","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"INSIG1 and SP1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In sterol-treated cells, the SCAP/SREBP compl... | |
medium_convergence_00609 | DPP4 and HSPA5 both interact with a shared protein. Evidence indicates that this shared protein, identified as a member of the ERdj family, interacts via its DnaJ domain with BiP in an ATP-dependent manner. Which protein is encoded by this gene? | Endoplasmic reticulum disulfide reductase DNAJC10 | Medium | convergence | {"qa_id":"medium_convergence_00609","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DPP4 and HSPA5 both interact with a shared protein. Evidence indicates that this shared protein, identified as a member of the ERdj family, interacts via its... | |
medium_convergence_00611 | SMURF1 and SMURF2 both interact with a specific shared protein. Evidence indicates that this shared protein is involved in a pathway where Smad7 mediates the association with TbetaR-I, leading to the enhanced turnover of both TbetaR-I and Smad7. Which protein is encoded by the gene corresponding to this shared entity? | TGF-beta receptor type-2 | Medium | convergence | {"qa_id":"medium_convergence_00611","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMURF1 and SMURF2 both interact with a specific shared protein. Evidence indicates that this shared protein is involved in a pathway where Smad7 mediates the... | |
medium_convergence_00613 | LATS2 and LATS1 each interact with multiple shared partners. Evidence concerning one such shared entity states: 'Further biochemical characterization of hMOBs showed that only hMOB1A and hMOB1B interact with both LATS1 and LATS2 in vitro and in vivo.' Which protein is encoded by the gene corresponding to the entity men... | MOB kinase activator 1A | Medium | convergence | {"qa_id":"medium_convergence_00613","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LATS2 and LATS1 each interact with multiple shared partners. Evidence concerning one such shared entity states: 'Further biochemical characterization of hMOB... | |
medium_convergence_00614 | YAP1 and MTOR share multiple interacting partners. One such shared partner is characterized by the following evidence: 'Under nutrient-enriched conditions, mTORC1 binds and phosphorylates this entity.' Which disease is associated with this specific shared partner? | xeroderma pigmentosum | Medium | convergence | {"qa_id":"medium_convergence_00614","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and MTOR share multiple interacting partners. One such shared partner is characterized by the following evidence: 'Under nutrient-enriched conditions, m... | |
medium_convergence_00615 | CPSF4 and CSTF1 both interact with a shared protein partner. Evidence regarding one such partner states: 'In a cleavage and polyadenylation specificity factor subunit, a small region, highly conserved in metazoa, is responsible for interactions with two proteins, CstF-77 and symplekin, a nuclear protein of previously u... | intellectual developmental disorder, X-linked 113 | Medium | convergence | {"qa_id":"medium_convergence_00615","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CPSF4 and CSTF1 both interact with a shared protein partner. Evidence regarding one such partner states: 'In a cleavage and polyadenylation specificity facto... | |
medium_convergence_00616 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Evidence for this shared target indicates a log2 fold change of -1.602 and an adjusted p-value of 0.04951. Which protein is encoded by this gene? | Paladin | Medium | convergence | {"qa_id":"medium_convergence_00616","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Evidence for this ... | |
medium_convergence_00617 | LIN37 and LIN52 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Using an integrated approach combining proteomics, genomics, and bioinformatic analyses, we identified a p130 complex termed DP, RB-like, E2F, and MuvB (DREAM) that contains mammalian homologs of... | Protein lin-54 homolog | Medium | convergence | {"qa_id":"medium_convergence_00617","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LIN37 and LIN52 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Using an integrated approach com... | |
medium_convergence_00618 | HSPA4 and YBX1 both interact with a specific shared protein. Experimental evidence indicates that using the RING finger domain of this shared protein as bait in a yeast two-hybrid screen identified YB-1 (Y-box binding protein 1) as a binding partner, with the interaction localized to the last 62 residues of YB-1. Which... | E3 ubiquitin-protein ligase RBBP6 | Medium | convergence | {"qa_id":"medium_convergence_00618","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA4 and YBX1 both interact with a specific shared protein. Experimental evidence indicates that using the RING finger domain of this shared protein as bait... | |
medium_convergence_00619 | Fluconazole and Triprolidine both interact with a specific drug. Evidence regarding this drug states: 'The MIC values of ITZ and FLZ of M. canis decreased in the presence of subinhibitory concentrations of HAL and PTZ, the latter being more effective with a greater increased susceptibility.' Which disease is this drug ... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00619","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Fluconazole and Triprolidine both interact with a specific drug. Evidence regarding this drug states: 'The MIC values of ITZ and FLZ of M. canis decreased in... | |
medium_convergence_00620 | Both Measles morbillivirus and Influenza A virus are associated with the downregulation of a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of -2.357 and an adjusted p-value of 2.367e-05. Which protein is encoded by this gene? | Kelch-like protein 4 | Medium | convergence | {"qa_id":"medium_convergence_00620","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are associated with the downregulation of a specific gene. Experimental data for this gene in pleural mesoth... | |
medium_convergence_00621 | CTNNB1 and PSEN1 share a common interacting partner. Evidence for one such partner states: 'Here we demonstrate the direct physical interaction between PSEN1 and two subunits, HC5 and the alpha-5 subunit, of the 20S proteasome.' Which protein is encoded by this shared interacting partner? | Proteasome subunit alpha type-5 | Medium | convergence | {"qa_id":"medium_convergence_00621","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and PSEN1 share a common interacting partner. Evidence for one such partner states: 'Here we demonstrate the direct physical interaction between PSEN1... | |
medium_convergence_00622 | FBXW11 and PPP1CB both interact with a common protein. Evidence indicates that this protein binds to βTrCP, the substrate-recognition subunit of the SCFβTrCP E3 ligase, leading to its ubiquitylation and degradation. Which gene encodes this protein? | NUAK family SNF1-like kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_00622","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and PPP1CB both interact with a common protein. Evidence indicates that this protein binds to βTrCP, the substrate-recognition subunit of the SCFβTrCP... | |
medium_convergence_00623 | Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) shows a log2 fold change of approximately -1.69 and an adjusted p-value of 0.0115. Which disease is associated with this gene via genomic alterations? | aneurysmal bone cyst | Medium | convergence | {"qa_id":"medium_convergence_00623","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) shows a log2 fo... | |
medium_convergence_00624 | PARP1 and CBX5 both interact with a specific histone protein. Experimental evidence indicates that this interaction occurs in vivo and in vitro, mediated by the hinge and C-terminal domains of the interacting partners, respectively. Which gene encodes this histone protein? | Histone H1.5 | Medium | convergence | {"qa_id":"medium_convergence_00624","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and CBX5 both interact with a specific histone protein. Experimental evidence indicates that this interaction occurs in vivo and in vitro, mediated by ... | |
medium_convergence_00625 | CREBBP and EGR2 both interact with a specific gene product. Evidence indicates that Akt phosphorylates CBP at threonine 1871, which suppresses its acetyltransferase activity by preventing CBP from binding to histone H3. Which protein is encoded by the gene product that interacts with both CREBBP and EGR2 and is involve... | Histone H3.1 | Medium | convergence | {"qa_id":"medium_convergence_00625","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and EGR2 both interact with a specific gene product. Evidence indicates that Akt phosphorylates CBP at threonine 1871, which suppresses its acetyltran... | |
medium_convergence_00626 | RPS27A and UBC both interact with a specific deubiquitinating enzyme. Evidence regarding this enzyme states: 'Here we report the crystal structures of the zinc-finger ubiquitin binding domain (ZnF UBP) from the deubiquitinating enzyme isopeptidase T alone and in complex with ubiquitin.' Which disease is associated with... | glioblastoma | Medium | convergence | {"qa_id":"medium_convergence_00626","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPS27A and UBC both interact with a specific deubiquitinating enzyme. Evidence regarding this enzyme states: 'Here we report the crystal structures of the zi... | |
medium_convergence_00627 | CENPI and CENPQ share multiple binding partners. One such partner is described in the following evidence: 'Here, we demonstrated that a protein directly interacts with CENP-Q, and this interaction was mutually required not only for their stability but also for their centromere localization.' Note that this protein is a... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00627","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPI and CENPQ share multiple binding partners. One such partner is described in the following evidence: 'Here, we demonstrated that a protein directly inte... | |
medium_convergence_00628 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.753 and an adjusted p-value of 2.981e-06. Which cell type is ... | mucosal-associated invariant T cell | Medium | convergence | {"qa_id":"medium_convergence_00628","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific shared gene. Experimental data f... | |
medium_convergence_00629 | CD247 and CD8A share a common binding partner. Evidence indicates that CD8alpha binds to this partner (specifically an HLA-A2/peptide complex), interfacing with its alpha2 and alpha3 domains and contacting beta2-microglobulin. Which cell type is enriched for this shared binding partner? | basophil | Medium | convergence | {"qa_id":"medium_convergence_00629","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CD247 and CD8A share a common binding partner. Evidence indicates that CD8alpha binds to this partner (specifically an HLA-A2/peptide complex), interfacing w... | |
medium_convergence_00630 | The biological processes 'negative regulation of gamma-aminobutyric acid secretion' and 'negative regulation of glycine import across plasma membrane' share a common parent process. Evidence regarding one of the shared entities states: 'Any process that stops, prevents, or reduces the frequency, rate or extent of the r... | organic acid transport | Medium | convergence | {"qa_id":"medium_convergence_00630","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'negative regulation of gamma-aminobutyric acid secretion' and 'negative regulation of glycine import across plasma membrane' share ... | |
medium_convergence_00631 | CBX3 and CBX8 both interact with a specific histone variant. Evidence regarding this interaction states: 'We find that the chromoshadow-domain interacts with histone H3 in a region located partially inside the nucleosomal barrel at the entry/exit point of the nucleosome.' Which disease is associated with this specific ... | squamous cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00631","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and CBX8 both interact with a specific histone variant. Evidence regarding this interaction states: 'We find that the chromoshadow-domain interacts with... | |
medium_convergence_00632 | HJURP and CENPM both interact with a shared protein entity. Evidence indicates that this entity is recruited to centromeres through a direct interaction between its centromere targeting domain and the Mis18α-β C-terminal coiled-coil domains. Which protein is encoded by the gene corresponding to this shared entity? | Protein Mis18-alpha | Medium | convergence | {"qa_id":"medium_convergence_00632","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HJURP and CENPM both interact with a shared protein entity. Evidence indicates that this entity is recruited to centromeres through a direct interaction betw... | |
medium_convergence_00633 | FUS and MECP2 share a common interacting partner. Evidence indicates that this shared partner does not promote DNA demethylation but instead mediates the ubiquitination of MECP2, a methyl-CpG-binding domain (MBD) protein. Which protein is encoded by this shared interacting partner? | E3 ubiquitin-protein ligase RNF4 | Medium | convergence | {"qa_id":"medium_convergence_00633","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FUS and MECP2 share a common interacting partner. Evidence indicates that this shared partner does not promote DNA demethylation but instead mediates the ubi... | |
medium_convergence_00634 | HSPA8 and ERBIN both interact with a shared protein entity. Evidence indicates that this entity is the protein kinase breakpoint cluster region, which functions as a negative regulator of cell proliferation and oncogenic transformation, and has been identified as an ERBIN ligand. Which protein is encoded by this shared... | Breakpoint cluster region protein | Medium | convergence | {"qa_id":"medium_convergence_00634","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA8 and ERBIN both interact with a shared protein entity. Evidence indicates that this entity is the protein kinase breakpoint cluster region, which functi... | |
medium_convergence_00635 | INSIG2 and SP1 both interact with a shared transcription factor. Evidence regarding this shared entity states: 'Two cDNA fragments encoding the same region of the SREBP-2 transcription factor were independently selected and two overlapping cDNA clones corresponded to the splicing factor SF3A120.' Which protein is encod... | Sterol regulatory element-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00635","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"INSIG2 and SP1 both interact with a shared transcription factor. Evidence regarding this shared entity states: 'Two cDNA fragments encoding the same region o... | |
medium_convergence_00636 | Both Human polyomavirus 1 and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in renal epithelial cells (from study GSE135833) indicates a log2 fold change of approximately 4.16 and an adjusted p-value of 0.0032. Which cellular component is the location of ... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00636","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human polyomavirus 1 and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in renal epithel... | |
medium_convergence_00637 | Palifermin and Gemtuzumab ozogamicin share a common interacting drug. Clinical evidence for this shared drug includes a Phase 1/2 trial titled 'Phase 1/2 Trial of CLAG-M with Dose-Escalated Mitoxantrone in Combination with Fractionated-Dose Gemtuzumab Ozogamicin for Newly Diagnosed Acute Myeloid Leukemia and Other High... | hairy cell leukemia | Medium | convergence | {"qa_id":"medium_convergence_00637","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Palifermin and Gemtuzumab ozogamicin share a common interacting drug. Clinical evidence for this shared drug includes a Phase 1/2 trial titled 'Phase 1/2 Tri... |
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