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medium_convergence_03960 | POMP and PSMA3 both interact with a specific proteasome subunit. Evidence indicates that proteassemblin interacts with beta5, but not beta5i, suggesting a role in the differential incorporation of these subunits. Which protein is encoded by the gene corresponding to this interacting subunit? | Proteasome subunit beta type-5 | Medium | convergence | {"qa_id":"medium_convergence_03960","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POMP and PSMA3 both interact with a specific proteasome subunit. Evidence indicates that proteassemblin interacts with beta5, but not beta5i, suggesting a ro... | |
medium_convergence_03961 | Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene has a log2 fold change of -1.236 and an adjusted p-value of 4.539e-06. Which protein does this gene product bind to? | IFNGR1 | Medium | convergence | {"qa_id":"medium_convergence_03961","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this... | |
medium_convergence_03962 | PRKDC and TTI2 both interact with a shared protein. Evidence regarding this shared entity states: 'Quantitative immunoblotting showed that the abundance of the shared protein is low compared with the PIKKs, and the shared protein preferentially bound newly synthesized ATM, ATR, mTOR, and DNA-PKcs.' Which disease is ass... | TELO2-related intellectual disability-neurodevelopmental disorder | Medium | convergence | {"qa_id":"medium_convergence_03962","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKDC and TTI2 both interact with a shared protein. Evidence regarding this shared entity states: 'Quantitative immunoblotting showed that the abundance of t... | |
medium_convergence_03963 | UBA52 and UBC each interact with more than one shared gene product. Evidence concerning one shared entity reports that OspG has been reported to bind host E2 ubiquitin-conjugating enzymes activated with ubiquitin (E2~Ub), a key enzyme complex in ubiquitin transfer pathways. Which protein is connected to that entity thr... | Ubiquitin-conjugating enzyme E2 D3 | Medium | convergence | {"qa_id":"medium_convergence_03963","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBA52 and UBC each interact with more than one shared gene product. Evidence concerning one shared entity reports that OspG has been reported to bind host E2... | |
medium_convergence_03964 | FBL and ZRANB1 both interact with a shared protein. Evidence indicates that this shared protein binds directly to fibrillarin and GAR1. Which protein is encoded by the gene corresponding to this shared entity? | Survival motor neuron protein | Medium | convergence | {"qa_id":"medium_convergence_03964","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBL and ZRANB1 both interact with a shared protein. Evidence indicates that this shared protein binds directly to fibrillarin and GAR1. Which protein is enco... | |
medium_convergence_03965 | EP300 and BRD4 both interact with a specific transcription factor. Evidence regarding this factor describes a tetra-mutant form in which four lysine residues were simultaneously mutated; this mutant retained nuclear localization and the ability to interact with cofactors including FOG-2, GATA6, and p300, but lacked p30... | Transcription factor GATA-4 | Medium | convergence | {"qa_id":"medium_convergence_03965","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and BRD4 both interact with a specific transcription factor. Evidence regarding this factor describes a tetra-mutant form in which four lysine residues... | |
medium_convergence_03966 | Rift Valley fever phlebovirus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of approximately 3.87 and an adjusted p-value of approximately 0.0019. Which protein is encoded by this gene? | Ubl carboxyl-terminal hydrolase 18 | Medium | convergence | {"qa_id":"medium_convergence_03966","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a lo... | |
medium_convergence_03969 | CHD4 and HDAC1 both interact with a shared protein component of the NuRD/Mi2 complex. Evidence indicates that the MBD domain of this shared entity is necessary and sufficient for binding to HDAC1 and MTA2. Which protein is encoded by this shared entity? | Methyl-CpG-binding domain protein 3 | Medium | convergence | {"qa_id":"medium_convergence_03969","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and HDAC1 both interact with a shared protein component of the NuRD/Mi2 complex. Evidence indicates that the MBD domain of this shared entity is necessa... | |
medium_convergence_03970 | Both Measles morbillivirus and Influenza A virus are associated with the downregulation of a specific gene. Experimental data for this gene reports a log2 fold change of approximately -1.062 and an adjusted p-value of 0.004681. Which protein is encoded by this gene? | Coiled-coil domain-containing protein 167 | Medium | convergence | {"qa_id":"medium_convergence_03970","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are associated with the downregulation of a specific gene. Experimental data for this gene reports a log2 fo... | |
medium_convergence_03971 | CSF1 and IL34 are both associated with the same biological process via the 'involved in' relationship. A specific piece of evidence states: 'We report here that IL-34 induces the differentiation of monocytes into CD14(high) CD163(high) CD1a(-) Mφ (IL-34-Mφ).' Which biological process, linked to this shared entity via t... | monocyte differentiation | Medium | convergence | {"qa_id":"medium_convergence_03971","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSF1 and IL34 are both associated with the same biological process via the 'involved in' relationship. A specific piece of evidence states: 'We report here t... | |
medium_convergence_03972 | HSPA1A and SMURF1 both interact with a common protein. Evidence indicates that this shared protein interacts with SMURF1 and is degraded via the ubiquitin-proteasome pathway mediated by SMURF1. Which protein is encoded by the gene corresponding to this shared entity? | Ubiquitin carboxyl-terminal hydrolase 5 | Medium | convergence | {"qa_id":"medium_convergence_03972","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA1A and SMURF1 both interact with a common protein. Evidence indicates that this shared protein interacts with SMURF1 and is degraded via the ubiquitin-pr... | |
medium_convergence_03974 | PRKACA and IQGAP1 both interact with a shared protein partner. Evidence regarding this partner states: 'We interrogated compound libraries using this assay in combination with a counter-screen based on luciferase complementation by the two subunits of protein kinase A (PKA).' Which protein is encoded by this shared par... | cAMP-dependent protein kinase type II-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_03974","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKACA and IQGAP1 both interact with a shared protein partner. Evidence regarding this partner states: 'We interrogated compound libraries using this assay i... | |
medium_convergence_03975 | FANCE and FAAP24 each interact with more than one shared protein partner. Evidence concerning one of these shared entities states: 'The human protein reportedly functions as a molecular adaptor within the FA nuclear complex, bridging between the subcomplexes A:G and C:E.' Which disease is connected to that entity throu... | Fanconi anemia | Medium | convergence | {"qa_id":"medium_convergence_03975","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCE and FAAP24 each interact with more than one shared protein partner. Evidence concerning one of these shared entities states: 'The human protein reporte... | |
medium_convergence_03976 | Both ACTN4 and ACTN2 interact with a shared protein partner. Experimental evidence involving immunoprecipitation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry indicates that nonmuscle alpha-actinin-1 and alpha-actinin-4 form complexes with this shared partner. Which protein is encoded... | PDZ and LIM domain protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03976","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ACTN4 and ACTN2 interact with a shared protein partner. Experimental evidence involving immunoprecipitation and matrix-assisted laser desorption/ionizat... | |
medium_convergence_03977 | Both seminal vesicle epithelium and seminiferous tubule epithelium share a common anatomical classification. Evidence regarding one of these shared entities describes it as 'An epithelium that is part of a seminal vesicle'. Which anatomical structure is the parent of this shared entity via a 'part of' relationship? | testis | Medium | convergence | {"qa_id":"medium_convergence_03977","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both seminal vesicle epithelium and seminiferous tubule epithelium share a common anatomical classification. Evidence regarding one of these shared entities ... | |
medium_convergence_03978 | EGFR and NEDD4L both interact with a specific shared protein. Evidence indicates that this shared protein is a substrate for NEDD4L, an E3 ligase involved in ubiquitin-mediated protein degradation, which binds to the Annexin 1 domain of the substrate and promotes its degradation. Which protein is encoded by the gene co... | Annexin A2 | Medium | convergence | {"qa_id":"medium_convergence_03978","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and NEDD4L both interact with a specific shared protein. Evidence indicates that this shared protein is a substrate for NEDD4L, an E3 ligase involved in... | |
medium_convergence_03979 | EGFR and PABPC1 share multiple interacting partners. One such shared partner is supported by evidence stating: 'For PABP1 and eIF4b the interactions were confirmed in the context of the corresponding full-length proteins in cellular lysates.' Which protein is encoded by this specific shared interacting partner? | Tumor susceptibility gene 101 protein | Medium | convergence | {"qa_id":"medium_convergence_03979","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and PABPC1 share multiple interacting partners. One such shared partner is supported by evidence stating: 'For PABP1 and eIF4b the interactions were con... | |
medium_convergence_03980 | Both Vaccinia virus and Human alphaherpesvirus 1 are known to downregulate a specific shared host gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE11238) indicates that this gene exhibits a log2 fold change of approximately -1.18 and an adjusted p-value of 0.00065. Which protein interacts ... | EIF5B | Medium | convergence | {"qa_id":"medium_convergence_03980","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Human alphaherpesvirus 1 are known to downregulate a specific shared host gene. Experimental data from a study on cervical adenocarci... | |
medium_convergence_03981 | CENPO and AURKB each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Approximately half of Aurora B in mitotic cells is complexed with the shared entity, Borealin, and Survivin; and Borealin binds Survivin and the shared entity in vitro.' Which protein is encoded by the gene ... | Inner centromere protein | Medium | convergence | {"qa_id":"medium_convergence_03981","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPO and AURKB each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Approximately half of Aurora B in mitotic ce... | |
medium_convergence_03982 | PRMT5 and BCL11A both interact with a shared protein. Evidence indicates that this shared protein contributes to germinal center formation and affinity maturation, at least in part, through its direct interaction with and methylation by PRMT5 at arginine 305 (R305). This specific modification is necessary for the full ... | B-cell lymphoma 6 protein | Medium | convergence | {"qa_id":"medium_convergence_03982","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRMT5 and BCL11A both interact with a shared protein. Evidence indicates that this shared protein contributes to germinal center formation and affinity matur... | |
medium_convergence_03983 | Both Cardiovirus A and Zaire ebolavirus are known to upregulate a specific gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE122967) indicates that for one such shared target, the log2 fold change is 2.752 and the adjusted p-value is 0.04051. Which cellular component is this specific gene l... | membrane | Medium | convergence | {"qa_id":"medium_convergence_03983","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Cardiovirus A and Zaire ebolavirus are known to upregulate a specific gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE122... | |
medium_convergence_03984 | DUOX2 and DUOX1 are both involved in a shared biological process. Evidence indicates that alterations to the NH(2)-terminal domain of DUOXA2 modify the activity of the associated enzyme, triggering superoxide leaking. Which biological process, connected to this entity via an 'is_a' relationship, is the correct answer? | superoxide metabolic process | Medium | convergence | {"qa_id":"medium_convergence_03984","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DUOX2 and DUOX1 are both involved in a shared biological process. Evidence indicates that alterations to the NH(2)-terminal domain of DUOXA2 modify the activ... | |
medium_convergence_03985 | Pegaspargase and Erythromycin both interact with a specific drug. Evidence regarding this drug states: 'Studies using the CYP3A4 inhibitors ketoconazole, troleandomycin, and erythromycin suggested a role for CYP3A4 in the formation of 2-, 8-, and 12-hydroxyNVP.' Which disease is this drug indicated for? | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_03985","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Pegaspargase and Erythromycin both interact with a specific drug. Evidence regarding this drug states: 'Studies using the CYP3A4 inhibitors ketoconazole, tro... | |
medium_convergence_03986 | Measles morbillivirus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) shows a log2 fold change of -1.075 and an adjusted p-value of 6.457e-05. Which disease is associated with this gene through genomic alterations? | myelomeningocele | Medium | convergence | {"qa_id":"medium_convergence_03986","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) sho... | |
medium_convergence_03989 | Both ADRB2 and PTGFRN interact with a common protein partner. Experimental evidence for one such partner indicates that cross-linking experiments detected a complex of the size of this protein plus its proteolytic fragment (P-1), demonstrating that these glycoproteins directly associate with each other, likely in the a... | CD9 antigen | Medium | convergence | {"qa_id":"medium_convergence_03989","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ADRB2 and PTGFRN interact with a common protein partner. Experimental evidence for one such partner indicates that cross-linking experiments detected a ... | |
medium_convergence_03990 | PRKN and UBA6 share multiple interacting partners. One such partner is described by the following evidence: 'Here, we show that Parkin binds to the E2 ubiquitin-conjugating human enzyme 8 through its C-terminal ring-finger.' Which cellular component is this specific interacting partner located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_03990","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and UBA6 share multiple interacting partners. One such partner is described by the following evidence: 'Here, we show that Parkin binds to the E2 ubiqui... | |
medium_convergence_03992 | Both Human immunodeficiency virus 1 and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene, derived from macrophages in study GSE108897, reports a log2 fold change of approximately 3.86 and an adjusted p-value of approximately 0.0093. What molecular function is enable... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03992","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene, derived from ... | |
medium_convergence_03993 | Both Human alphaherpesvirus 3 and Cardiovirus A are known to downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.168 and an adjusted p-value of 2.019e-05. Which disease is associated with this gene as a biomarker? | kidney neoplasm | Medium | convergence | {"qa_id":"medium_convergence_03993","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Cardiovirus A are known to downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (st... | |
medium_convergence_03995 | PPP2CA and YWHAH share multiple interacting partners. One such shared partner is supported by evidence stating that a specific mRNA decay activator physically interacted with PP2A in transfected mammalian cells. Which protein is encoded by this shared partner? | mRNA decay activator protein ZFP36 | Medium | convergence | {"qa_id":"medium_convergence_03995","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CA and YWHAH share multiple interacting partners. One such shared partner is supported by evidence stating that a specific mRNA decay activator physicall... | |
medium_convergence_03996 | BRD4 and KPNB1 share a common interacting partner. Evidence indicates that for one such shared partner, Gβγ and clathrin regulate its nuclear entry by mediating the interaction between this partner and importin β1. Which disease is associated with this specific shared partner? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_03996","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and KPNB1 share a common interacting partner. Evidence indicates that for one such shared partner, Gβγ and clathrin regulate its nuclear entry by mediat... | |
medium_convergence_03997 | EGFR and LRRC59 share common interaction partners. One such partner is described in evidence stating: 'Analysis of the interaction in prostate carcinoma cells between this protein and leucine-rich repeat-containing protein 59 suggests that this protein is translocated into the nucleus at G2/M through its association wi... | chromosome | Medium | convergence | {"qa_id":"medium_convergence_03997","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and LRRC59 share common interaction partners. One such partner is described in evidence stating: 'Analysis of the interaction in prostate carcinoma cell... | |
medium_convergence_03998 | Both Vaccinia virus and Influenza A virus are known to downregulate a specific shared gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE11238) indicates that this gene exhibits a log2 fold change of approximately -1.48 and an adjusted p-value of 0.0137. Which protein interacts with this dow... | MMGT1 | Medium | convergence | {"qa_id":"medium_convergence_03998","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Influenza A virus are known to downregulate a specific shared gene. Experimental data from a study on cervical adenocarcinoma cell li... | |
medium_convergence_03999 | BMAL1 and CLOCK each interact with more than one shared partner. Evidence concerning one such shared partner indicates that it (or its homolog) engages in light-independent interactions with BMAL1 and CLOCK, as well as with PER1, PER2, and TIM. Which cell type is enriched for this specific shared partner? | mucosal-associated invariant T cell | Medium | convergence | {"qa_id":"medium_convergence_03999","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMAL1 and CLOCK each interact with more than one shared partner. Evidence concerning one such shared partner indicates that it (or its homolog) engages in li... | |
medium_convergence_04000 | Both Human alphaherpesvirus 3 and Rhinovirus A are reported to upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately 3.046 and an adjusted p-value of 4.455e-12. Which protein is encoded by this gene? | Phorbol-12-myristate-13-acetate-induced protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04000","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Rhinovirus A are reported to upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE... | |
medium_convergence_04001 | CHEK2 and BABAM2 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'This association is mediated by the [entity] FHA domain and the phosphorylated Thr 68 of CHK2.' Which disease is connected to that specific entity through a biomarker relationship? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04001","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and BABAM2 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'This association is mediated by t... | |
medium_convergence_04002 | Lepirudin and Bivalirudin both interact with a specific drug. Clinical evidence from the HIT-4 trial demonstrates that Recombinant hirudin (Lepirudin) improves thrombolysis outcomes when combined with this specific drug in patients with acute myocardial infarction. What disease is this specific drug indicated for? | pulmonary embolism | Medium | convergence | {"qa_id":"medium_convergence_04002","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Lepirudin and Bivalirudin both interact with a specific drug. Clinical evidence from the HIT-4 trial demonstrates that Recombinant hirudin (Lepirudin) improv... | |
medium_convergence_04003 | ESR1 and HNF4G share multiple binding partners. One such partner is implicated in evidence stating: 'In vivo and in vitro binding assays revealed that whereas 4-hydroxytamoxifen (OHT) induced binding of ERalpha to both an AF-1 coactivator complex (p68/p72 and p300) and corepressor complexes (a corepressor protein/SMRT)... | Nuclear receptor corepressor 1 | Medium | convergence | {"qa_id":"medium_convergence_04003","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HNF4G share multiple binding partners. One such partner is implicated in evidence stating: 'In vivo and in vitro binding assays revealed that wherea... | |
medium_convergence_04004 | CREBBP and DDX3X both interact with a specific transcription factor. Experimental evidence indicates that this transcription factor interacts with CBP in a ligand-independent manner, specifically involving the middle portion (amino acids 119-375) of the transcription factor and two distinct regions (amino acids 271-451... | Hepatocyte nuclear factor 4-alpha | Medium | convergence | {"qa_id":"medium_convergence_04004","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and DDX3X both interact with a specific transcription factor. Experimental evidence indicates that this transcription factor interacts with CBP in a l... | |
medium_convergence_04005 | Cyclosporine and Terfenadine share a common drug interaction partner. Evidence regarding one such partner specifically describes the pharmacokinetic and pharmacodynamic interaction between that drug and Terfenadine. Which disease is that shared drug indicated for? | asthma | Medium | convergence | {"qa_id":"medium_convergence_04005","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyclosporine and Terfenadine share a common drug interaction partner. Evidence regarding one such partner specifically describes the pharmacokinetic and phar... | |
medium_convergence_04006 | YWHAQ and NEDD4L both interact with a shared protein. Evidence regarding this shared entity states: 'Further evidence for the importance of this protein in this process comes from the ability of Nedd4-2 to bind to it.' Which protein is encoded by the gene corresponding to this shared entity? | Serine/threonine-protein kinase WNK1 | Medium | convergence | {"qa_id":"medium_convergence_04006","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and NEDD4L both interact with a shared protein. Evidence regarding this shared entity states: 'Further evidence for the importance of this protein in t... | |
medium_convergence_04007 | IL15 and IL23A are both involved in more than one shared biological process. Evidence indicates that IL-23 enhances IL-17 secretion, a function shared by IL-2, IL-15, IL-18, and IL-21. Which biological process, connected to this shared entity via the relation 'positively regulates', is best supported by this evidence? | interleukin-17 production | Medium | convergence | {"qa_id":"medium_convergence_04007","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL15 and IL23A are both involved in more than one shared biological process. Evidence indicates that IL-23 enhances IL-17 secretion, a function shared by IL-... | |
medium_convergence_04009 | ASAP1 and EXOC6 both interact with a common protein partner. Experimental evidence indicates that this shared partner directly binds to FIP3 via its BAR domain, as confirmed by coimmunoprecipitation and in vitro pulldown assays. Which gene encodes this shared protein partner? | Rab11 family-interacting protein 3 | Medium | convergence | {"qa_id":"medium_convergence_04009","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ASAP1 and EXOC6 both interact with a common protein partner. Experimental evidence indicates that this shared partner directly binds to FIP3 via its BAR doma... | |
medium_convergence_04011 | STUB1 and NFAT5 both interact with a specific shared protein. Evidence indicates that STUB1 interacts with this protein, ubiquitinates it, and targets it for degradation in a chaperone-dependent manner. Which protein is encoded by the gene corresponding to this shared interaction partner? | Protein argonaute-2 | Medium | convergence | {"qa_id":"medium_convergence_04011","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and NFAT5 both interact with a specific shared protein. Evidence indicates that STUB1 interacts with this protein, ubiquitinates it, and targets it for... | |
medium_convergence_04012 | BMPR2 and ACVR2A share common interaction partners. One such partner is described as a transmembrane serine/threonine kinase (BMPR-II) that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which protein is encoded by the gene corresponding to this specifi... | Bone morphogenetic protein receptor type-1A | Medium | convergence | {"qa_id":"medium_convergence_04012","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMPR2 and ACVR2A share common interaction partners. One such partner is described as a transmembrane serine/threonine kinase (BMPR-II) that binds BMP-2 and B... | |
medium_convergence_04013 | The His-Purkinje system and the Purkinje fiber network are both subtypes of a specific anatomical entity. Evidence indicates that this entity receives signals from the AV node and is composed of fibers that regulate cardiac muscle contraction in the ventricles. Which anatomical category is this entity a subtype of? | cardiac muscle tissue | Medium | convergence | {"qa_id":"medium_convergence_04013","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The His-Purkinje system and the Purkinje fiber network are both subtypes of a specific anatomical entity. Evidence indicates that this entity receives signal... | |
medium_convergence_04015 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of approximately 1.034 and an adjusted p-value of 0.006443. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04015","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of a... | |
medium_convergence_04017 | Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data from a retinal pigment epithelium cell line (study GSE100839) indicates that this gene has a log2 fold change of -1.458 and an adjusted p-value of 0.002794. Which protein is encoded by this gene? | Protein sprouty homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_04017","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data from a retinal pigment epithelium cell line (study GSE100839) indicates ... | |
medium_convergence_04018 | CDCA8 and AURKB each interact with more than one shared partner. Evidence concerning one shared entity reports that Aurora B directly binds to the substrate-recognition domain of this entity in vitro and coimmunoprecipitates with the Cul3 complex during mitosis. Which cellular component is connected to that entity thro... | Cul3-RING ubiquitin ligase complex | Medium | convergence | {"qa_id":"medium_convergence_04018","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDCA8 and AURKB each interact with more than one shared partner. Evidence concerning one shared entity reports that Aurora B directly binds to the substrate-... | |
medium_convergence_04019 | Both FOXO1 and FOXO3 interact with a specific protein. Evidence indicates that this protein, an NAD-dependent deacetylase, forms a complex with FOXO1 and the promyelocytic leukemia protein Pml to protect beta cells against oxidative stress and activate the expression of NeuroD and MafA. Which gene encodes this protein? | NAD-dependent protein deacetylase sirtuin-1 | Medium | convergence | {"qa_id":"medium_convergence_04019","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both FOXO1 and FOXO3 interact with a specific protein. Evidence indicates that this protein, an NAD-dependent deacetylase, forms a complex with FOXO1 and the... | |
medium_convergence_04020 | NUB1 and PSMA3 both interact with a common protein partner. Experimental evidence indicates that a yeast two-hybrid screen identified NEDD8 ultimate buster-1L (NUB1L) as a non-covalent binding partner of a ubiquitin-like modifier, an interaction confirmed by coimmunoprecipitation and glutathione S-transferase pull-down... | Ubiquitin D | Medium | convergence | {"qa_id":"medium_convergence_04020","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUB1 and PSMA3 both interact with a common protein partner. Experimental evidence indicates that a yeast two-hybrid screen identified NEDD8 ultimate buster-1... | |
medium_convergence_04021 | AMPH and BIN1 both interact with a shared protein partner. Evidence regarding one such partner states: 'The simplest interaction appeared to take place with the amphiphysin-SH3 domain; this bound to a single high affinity site (K(D) approximately 10 nm) in the C terminus of dynamin-1 PRD, as predicted by previous studi... | Dynamin-2 | Medium | convergence | {"qa_id":"medium_convergence_04021","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMPH and BIN1 both interact with a shared protein partner. Evidence regarding one such partner states: 'The simplest interaction appeared to take place with ... | |
medium_convergence_04023 | MECP2 and FBXW7 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Whereas the N-terminal region of this protein interacts with c-Myc, the rest of the helicase interacts with the c-Myc E3 ligase Fbw7.' Which protein is encoded by this shared entity? | RecQ-like DNA helicase BLM | Medium | convergence | {"qa_id":"medium_convergence_04023","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MECP2 and FBXW7 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Whereas the N-terminal region of this protein i... | |
medium_convergence_04024 | TNRC6A and RNF219 share a common interacting partner. Evidence regarding one such shared partner states: 'We demonstrate that RNF219 is an active RING-type E3 ligase which stably associates with CCR4-NOT via NOT9 through a short linear motif (SLiM) embedded within the C-terminal low-complexity region of RNF219.' Which ... | KIAA0232 | Medium | convergence | {"qa_id":"medium_convergence_04024","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNRC6A and RNF219 share a common interacting partner. Evidence regarding one such shared partner states: 'We demonstrate that RNF219 is an active RING-type E... | |
medium_convergence_04025 | Human alphaherpesvirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (study GSE100576) reports a log2 fold change of approximately 1.588 and an adjusted p-value of 0.04214. Which protein is encoded by this gene? | 2'-5'-oligoadenylate synthase 3 | Medium | convergence | {"qa_id":"medium_convergence_04025","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (study GSE100576)... | |
medium_convergence_04026 | CHRM4 and GNB1 both interact with multiple shared protein partners. One such shared partner is implicated in evidence stating: 'Co-immunoprecipitation assays using Cos-7 cells transiently expressing 48 different combinations of Gbeta(1-4) and Ggamma(1-5, 7-13) subunits showed that Gbeta(1) and Gbeta(4) could form dimer... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | Medium | convergence | {"qa_id":"medium_convergence_04026","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHRM4 and GNB1 both interact with multiple shared protein partners. One such shared partner is implicated in evidence stating: 'Co-immunoprecipitation assays... | |
medium_convergence_04027 | CBX3 and DDB1 both interact with a specific gene product. Evidence regarding this shared entity states: 'We identified three ubiquitylated lysine residues and showed that DNA ligase I interacts with and is targeted for ubiquitylation by DCAF7, a specificity factor for the Cul4-DDB1 complex.' Which protein is encoded by... | DNA ligase 1 | Medium | convergence | {"qa_id":"medium_convergence_04027","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and DDB1 both interact with a specific gene product. Evidence regarding this shared entity states: 'We identified three ubiquitylated lysine residues an... | |
medium_convergence_04029 | UBLCP1 and KCNA3 both interact with a specific proteasome regulatory subunit. Evidence indicates that this shared partner binds to proteasome subunit Rpn1 and dephosphorylates the proteasome. Which protein is encoded by this shared partner? | 26S proteasome non-ATPase regulatory subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_04029","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBLCP1 and KCNA3 both interact with a specific proteasome regulatory subunit. Evidence indicates that this shared partner binds to proteasome subunit Rpn1 an... | |
medium_convergence_04030 | CBX5 and XRCC6 both interact with a specific shared protein. Experimental evidence indicates that in a yeast two-hybrid screen, the nucleoplasmic domain of this shared entity, identified as an integral protein of the inner nuclear membrane, associated with two human polypeptides homologous to Drosophila HP1, a heteroch... | Delta(14)-sterol reductase LBR | Medium | convergence | {"qa_id":"medium_convergence_04030","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX5 and XRCC6 both interact with a specific shared protein. Experimental evidence indicates that in a yeast two-hybrid screen, the nucleoplasmic domain of t... | |
medium_convergence_04031 | DCC and ABLIM1 share a common binding partner. Evidence indicates that sNetrin binds exclusively to the fifth fibronectin type III repeat of this shared entity and to each immunoglobulin repeat of UNC5. Which protein is encoded by this shared entity? | Netrin-1 | Medium | convergence | {"qa_id":"medium_convergence_04031","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCC and ABLIM1 share a common binding partner. Evidence indicates that sNetrin binds exclusively to the fifth fibronectin type III repeat of this shared enti... | |
medium_convergence_04032 | CRKL and EGFR share multiple interacting partners. One such partner is described by evidence stating that it constitutively binds Grb2 and becomes associated with Crk-L upon TCR stimulation. Which cellular component is this specific partner located in? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_04032","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRKL and EGFR share multiple interacting partners. One such partner is described by evidence stating that it constitutively binds Grb2 and becomes associated... | |
medium_convergence_04033 | FANCC and FAAP24 both interact with a specific protein. Evidence regarding this shared partner states: 'Here, we show that this protein forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF.' Which protein is encoded by this shared partner? | Fanconi anemia group M protein | Medium | convergence | {"qa_id":"medium_convergence_04033","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCC and FAAP24 both interact with a specific protein. Evidence regarding this shared partner states: 'Here, we show that this protein forms a conserved DNA... | |
medium_convergence_04035 | Human betaherpesvirus 5 and Human orthopneumovirus both upregulate a specific gene. Evidence for this shared target in dendritic cells reports a log2 fold change of 1.563 and an adjusted p-value of 0.04004. Which protein is encoded by this gene? | mRNA decay activator protein ZFP36 | Medium | convergence | {"qa_id":"medium_convergence_04035","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human orthopneumovirus both upregulate a specific gene. Evidence for this shared target in dendritic cells reports a log2 fold ch... | |
medium_convergence_04036 | ALK and NEDD4 both interact with a specific shared protein. Evidence indicates that TMEM127 binds to this shared protein and recruits NEDD4, an E3 ubiquitin ligase, to facilitate the ubiquitination and degradation of the shared protein via TMEM127's C-terminal PxxY motifs. Which gene encodes this shared protein? | Proto-oncogene tyrosine-protein kinase receptor Ret | Medium | convergence | {"qa_id":"medium_convergence_04036","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALK and NEDD4 both interact with a specific shared protein. Evidence indicates that TMEM127 binds to this shared protein and recruits NEDD4, an E3 ubiquitin ... | |
medium_convergence_04037 | Both ELOC and ELOB share binding partners. One such shared partner is described as follows: 'Like other SOCS family members, SOCS-6 binds to elongins B and C through its SOCS box, suggesting that it might act as an E3 ubiquitin ligase that targets proteins bound to its SH2 domain for ubiquitination and proteasomal degr... | UBE2F | Medium | convergence | {"qa_id":"medium_convergence_04037","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ELOC and ELOB share binding partners. One such shared partner is described as follows: 'Like other SOCS family members, SOCS-6 binds to elongins B and C... | |
medium_convergence_04038 | Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus upregulate a specific gene. Evidence for this shared target indicates a log2 fold change of approximately 1.437 and an adjusted p-value of 0.04844. Which biological process is this gene involved in? | positive regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_04038","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus upregulate a specific gene. Evidence for this shared target indicates a l... | |
medium_convergence_04039 | CPSF6 and ESR1 share multiple interacting partners. One such partner is characterized by evidence stating: 'Immunoprecipitation indicates that this protein associates with the N-terminal of ER alpha in the cytoplasm via its HECT domain.' Which protein is encoded by this specific interacting partner? | E3 ubiquitin-protein ligase SMURF1 | Medium | convergence | {"qa_id":"medium_convergence_04039","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CPSF6 and ESR1 share multiple interacting partners. One such partner is characterized by evidence stating: 'Immunoprecipitation indicates that this protein a... | |
medium_convergence_04040 | Both outer root sheath cells and hair germinal matrix cells are subtypes of a specific cell class. Evidence indicates that an epithelial cell belonging to the outer root sheath is an instance of this class. Which anatomical structure is this cell class a part of? | outer epithelium | Medium | convergence | {"qa_id":"medium_convergence_04040","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both outer root sheath cells and hair germinal matrix cells are subtypes of a specific cell class. Evidence indicates that an epithelial cell belonging to th... | |
medium_convergence_04041 | DMD and AGRN share multiple protein interaction partners. One such shared partner is described in the following evidence: 'Finally, we used in vitro translated proteins in an immunoprecipitation assay to show that, like beta 1-syntrophin, both beta 2- and alpha 1-syntrophin interact with peptides encoding the syntrophi... | Beta-2-syntrophin | Medium | convergence | {"qa_id":"medium_convergence_04041","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DMD and AGRN share multiple protein interaction partners. One such shared partner is described in the following evidence: 'Finally, we used in vitro translat... | |
medium_convergence_04042 | YAP1 and COPS5 both interact with a shared protein. Experimental evidence indicates that this protein, referred to as a thioredoxin family member, colocalizes and directly interacts with Jab1, as demonstrated by fluorescence resonance energy transfer and co-immunoprecipitation studies. Which disease is associated with ... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04042","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and COPS5 both interact with a shared protein. Experimental evidence indicates that this protein, referred to as a thioredoxin family member, colocalize... | |
medium_convergence_04043 | The intervertebral disk of the cervical vertebra and the intervertebral disk of the lumbar vertebra share a common anatomical classification. Evidence regarding one such shared entity describes it as an intervertebral disk that is part of the cervical region of the vertebral column, connecting at least one cervical ver... | cartilage element | Medium | convergence | {"qa_id":"medium_convergence_04043","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The intervertebral disk of the cervical vertebra and the intervertebral disk of the lumbar vertebra share a common anatomical classification. Evidence regard... | |
medium_convergence_04044 | ASB18 and CUL5 both interact with a shared protein. Evidence regarding this shared entity states: 'We show that a protein encoded by the gene DCUN1D1 binds to the components of the neddylation pathway (Cullin-ROC1, Ubc12, and CAND1) and augments but is not required for cullin neddylation in reactions using purified rec... | DCN1-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04044","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ASB18 and CUL5 both interact with a shared protein. Evidence regarding this shared entity states: 'We show that a protein encoded by the gene DCUN1D1 binds t... | |
medium_convergence_04045 | West Nile virus and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in monocyte-derived dendritic cells (from study GSE136342) reports a log2 fold change of 1.415 and an adjusted p-value of 0.04609. Which protein is encoded by this gene? | Antiviral innate immune response effector IFIT1 | Medium | convergence | {"qa_id":"medium_convergence_04045","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"West Nile virus and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in monocyte-derived dendritic cells (from study... | |
medium_convergence_04046 | DPY30 and ASH2L both interact with a common protein partner. Evidence regarding this partner states: 'Here we show that a minimized human RBBP5-ASH2L heterodimer is the structural unit that interacts with and activates all MLL family histone methyltransferases.' Which disease is associated with this protein partner? | intellectual developmental disorder with seizures and language delay | Medium | convergence | {"qa_id":"medium_convergence_04046","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DPY30 and ASH2L both interact with a common protein partner. Evidence regarding this partner states: 'Here we show that a minimized human RBBP5-ASH2L heterod... | |
medium_convergence_04047 | CSTF1 and CHTOP both interact with a shared protein partner. Evidence regarding one such partner states: 'In a cleavage and polyadenylation specificity factor subunit, a small region, highly conserved in metazoa, is responsible for interactions with two proteins, CstF-77 and symplekin, a nuclear protein of previously u... | intellectual developmental disorder, X-linked 113 | Medium | convergence | {"qa_id":"medium_convergence_04047","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSTF1 and CHTOP both interact with a shared protein partner. Evidence regarding one such partner states: 'In a cleavage and polyadenylation specificity facto... | |
medium_convergence_04048 | Both Influenza A virus and Cardiovirus A are reported to upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line shows a log2 fold change of 1.054 and an adjusted p-value of 0.02595. Which protein is encoded by this gene? | CD83 antigen | Medium | convergence | {"qa_id":"medium_convergence_04048","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Cardiovirus A are reported to upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma ... | |
medium_convergence_04049 | EGFR and CTTN both interact with a shared protein. Evidence indicates that the majority of this shared protein is localized to the cytoplasmic fraction, where it forms a complex with the actin-binding protein cortactin. Which protein is encoded by the gene corresponding to this shared entity? | Tyrosine-protein kinase Fer | Medium | convergence | {"qa_id":"medium_convergence_04049","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and CTTN both interact with a shared protein. Evidence indicates that the majority of this shared protein is localized to the cytoplasmic fraction, wher... | |
medium_convergence_04050 | ACTR3 and AP2S1 both interact with a shared protein. Evidence for one such shared partner indicates that its NTA region interacts directly with the Arp2/3 complex, as demonstrated by affinity chromatography, immunoprecipitation assays, and binding assays using purified components. Which cell type is this specific share... | peripheral blood mononuclear cell | Medium | convergence | {"qa_id":"medium_convergence_04050","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR3 and AP2S1 both interact with a shared protein. Evidence for one such shared partner indicates that its NTA region interacts directly with the Arp2/3 co... | |
medium_convergence_04051 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene in lung fibroblast cell lines (from study GSE120891) reports a log2 fold change of approximately 1.07 and an adjusted p-value of 0.038. Which disease is c... | hypokalemic periodic paralysis | Medium | convergence | {"qa_id":"medium_convergence_04051","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for t... | |
medium_convergence_04052 | POLR2E and TAF1 both interact with a shared protein partner. Contextual evidence indicates that a complex involving TAF(II)250 and TAF(II)150 selects sequences matching the Initiator (Inr) consensus. Which protein, encoded by the gene corresponding to this shared partner, is the subject of this description? | Transcription initiation factor TFIID subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_04052","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLR2E and TAF1 both interact with a shared protein partner. Contextual evidence indicates that a complex involving TAF(II)250 and TAF(II)150 selects sequenc... | |
medium_convergence_04053 | PSMA1 and PSMA3 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which disease is associated with this protein pa... | lung cancer | Medium | convergence | {"qa_id":"medium_convergence_04053","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA1 and PSMA3 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S prote... | |
medium_convergence_04054 | Both Human alphaherpesvirus 1 and Zika virus are known to upregulate the expression of a specific host gene. In a study using a monocytic leukemia cell line (GSE114966), the upregulation of this gene was associated with a log2 fold change of approximately 1.23 and an adjusted p-value of approximately 0.035. What molecu... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_04054","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Zika virus are known to upregulate the expression of a specific host gene. In a study using a monocytic leukemia cell line ... | |
medium_convergence_04055 | EHMT2 and HDAC1 share multiple interaction partners. One such shared partner is described by the following evidence: 'Strikingly, we found that this protein binds to both SUV39H1 and G9A histone methyl transferases, which provides a direct link between histone methylation and this protein at heterochromatic and euchrom... | platelet-type bleeding disorder 17 | Medium | convergence | {"qa_id":"medium_convergence_04055","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and HDAC1 share multiple interaction partners. One such shared partner is described by the following evidence: 'Strikingly, we found that this protein ... | |
medium_convergence_04056 | NCOA2 and KMT2C both interact with a shared protein. Evidence indicates that a complex involving this shared protein possesses robust histone methyltransferase (HMT) activity and specifically methylates lysine 4 (K4) on histone H3. Which protein is encoded by this shared entity? | PAXIP1-associated glutamate-rich protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04056","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCOA2 and KMT2C both interact with a shared protein. Evidence indicates that a complex involving this shared protein possesses robust histone methyltransfera... | |
medium_convergence_04057 | LAMTOR1 and RB1CC1 both interact with a specific protein. Evidence describes this protein as an uncharacterized entity with sequence similarity to amino acid transporters, identified as a lysosomal transmembrane protein that interacts with Rag GTPases and Ragulator in an amino acid-sensitive manner. Which protein is en... | Neutral amino acid transporter 9 | Medium | convergence | {"qa_id":"medium_convergence_04057","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR1 and RB1CC1 both interact with a specific protein. Evidence describes this protein as an uncharacterized entity with sequence similarity to amino acid... | |
medium_convergence_04058 | LAMTOR2 and ATG13 both interact with a shared protein partner. Evidence regarding this partner states: 'In a two-hybrid screen with p14 as a bait, we identified the mitogen-activated protein kinase (MAPK) scaffolding protein MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) partner 1 as an interacting prote... | Ragulator complex protein LAMTOR3 | Medium | convergence | {"qa_id":"medium_convergence_04058","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR2 and ATG13 both interact with a shared protein partner. Evidence regarding this partner states: 'In a two-hybrid screen with p14 as a bait, we identif... | |
medium_convergence_04059 | PRKN and RAC1 share multiple interacting partners. One such partner is described by the following evidence: 'The PAR6 proteins harbour a PDZ domain and a CRIB-like motif, and directly interact with GTP-bound Rac and Cdc42 via this motif and with the aPKC isoforms PKCiota/lambda and PKCzeta via the N-terminal head-to-he... | Partitioning defective 6 homolog beta | Medium | convergence | {"qa_id":"medium_convergence_04059","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and RAC1 share multiple interacting partners. One such partner is described by the following evidence: 'The PAR6 proteins harbour a PDZ domain and a CRI... | |
medium_convergence_04060 | Both Human respirovirus 3 and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data from a non-small cell lung adenocarcinoma cell line (study GSE147507) indicates that this shared gene exhibits a log2 fold change of approximately 1.409 and an adjusted p-value of 0.04933. Whic... | HGS | Medium | convergence | {"qa_id":"medium_convergence_04060","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data from a non-small cell lung ade... | |
medium_convergence_04061 | KAT6B and PIN1 both interact with a specific shared protein. Evidence indicates that MORF binds to this shared protein in vitro and in vivo through its C-terminal SM (serine- and methionine-rich) domain. Which protein is encoded by this shared entity? | Runt-related transcription factor 2 | Medium | convergence | {"qa_id":"medium_convergence_04061","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT6B and PIN1 both interact with a specific shared protein. Evidence indicates that MORF binds to this shared protein in vitro and in vivo through its C-ter... | |
medium_convergence_04062 | STX6 and RHOA share multiple interacting partners. One such partner is identified by evidence stating: 'In vitro binding studies established that SNAP-23 binds to syntaxin 6.' Which protein is encoded by this specific interacting partner? | Synaptosomal-associated protein 23 | Medium | convergence | {"qa_id":"medium_convergence_04062","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STX6 and RHOA share multiple interacting partners. One such partner is identified by evidence stating: 'In vitro binding studies established that SNAP-23 bin... | |
medium_convergence_04063 | ATP6V0B and RPTOR each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'The Rag GTPases play an essential role in relaying amino acid signals to TORC1 activation through direct interaction with raptor and recruitment of the TORC1 complex to lysosomes.' Which protein ... | Ras-related GTP-binding protein C | Medium | convergence | {"qa_id":"medium_convergence_04063","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATP6V0B and RPTOR each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'The Rag GTPases play an essentia... | |
medium_convergence_04064 | BRCA1 and FAM175A (Abraxas) share common protein interaction partners. One such shared partner is known to associate with Abraxas through coiled-coil domains on each protein. Which disease is associated with this specific shared partner? | leiomyoma | Medium | convergence | {"qa_id":"medium_convergence_04064","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCA1 and FAM175A (Abraxas) share common protein interaction partners. One such shared partner is known to associate with Abraxas through coiled-coil domains... | |
medium_convergence_04065 | KDM1A and NEDD4 both interact with a specific shared protein. Evidence regarding this protein states: 'Using immunoaffinity purification, we identified the nuclear partners in T-ALL cells and showed that, beyond the well-characterized core activation complex (ICN1-CSL-MAML1), this protein assembles a multifunctional co... | Neurogenic locus notch homolog protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04065","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KDM1A and NEDD4 both interact with a specific shared protein. Evidence regarding this protein states: 'Using immunoaffinity purification, we identified the n... | |
medium_convergence_04066 | CSNK2B and MAPK1 share multiple interacting partners. One such partner is described in a report stating: 'In this report we show that RSK1 and ERK1/2 form a complex in quiescent HEK293 cells that transiently dissociates upon mitogen stimulation.' Which gene is connected to this specific shared partner through a 'binds'... | SH3GL2 | Medium | convergence | {"qa_id":"medium_convergence_04066","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and MAPK1 share multiple interacting partners. One such partner is described in a report stating: 'In this report we show that RSK1 and ERK1/2 form a ... | |
medium_convergence_04067 | HSPA1B and HSPA8 each share a binding partner with another protein. Evidence indicates that one such shared partner, a co-chaperone, interacts with a portion of the carboxy-terminal domain of hsp70s, a region distinct from that involved in the binding of misfolded proteins. Which protein is encoded by the gene correspo... | Stress-induced-phosphoprotein 1 | Medium | convergence | {"qa_id":"medium_convergence_04067","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA1B and HSPA8 each share a binding partner with another protein. Evidence indicates that one such shared partner, a co-chaperone, interacts with a portion... | |
medium_convergence_04068 | DLG1 and DLG4 both interact with a specific potassium channel gene. Evidence indicates that the protein encoded by this gene-associated brain proteins include members of the MAGUK family (such as SAP97, PSD-95, Chapsyn-110, SAP102, CASK, Dlg2, Dlg3, and Pals2), Veli isoforms, Mint1, and abLIM. Which protein is encoded ... | ATP-sensitive inward rectifier potassium channel 12 | Medium | convergence | {"qa_id":"medium_convergence_04068","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG1 and DLG4 both interact with a specific potassium channel gene. Evidence indicates that the protein encoded by this gene-associated brain proteins includ... | |
medium_convergence_04069 | DSG4 and DSG3 share binding partners. One such partner is described by the evidence: 'We found that this protein binds all three desmogleins, desmocollin (Dsc) 3a and -3b, and possibly also Dsc1a and -2a.' Which protein is encoded by this specific binding partner? | Plakophilin-3 | Medium | convergence | {"qa_id":"medium_convergence_04069","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DSG4 and DSG3 share binding partners. One such partner is described by the evidence: 'We found that this protein binds all three desmogleins, desmocollin (Ds... | |
medium_convergence_04071 | Human polyomavirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (from study GSE135833) reports a log2 fold change of approximately 1.29 and an adjusted p-value of approximately 0.0195. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04071","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (from study GSE135833) reports... | |
medium_convergence_04072 | CALCOCO2 and RHOA share multiple interacting partners. One such shared partner is identified by evidence stating: 'Here, we show that NDP52 interacts with mitochondrial RNA poly(A) polymerase via the SKICH domain.' Which disease is associated with this entity? | spastic ataxia 4 | Medium | convergence | {"qa_id":"medium_convergence_04072","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CALCOCO2 and RHOA share multiple interacting partners. One such shared partner is identified by evidence stating: 'Here, we show that NDP52 interacts with mi... | |
medium_convergence_04073 | CD160 and AP1G1 are both associated with multiple shared biological processes. One specific piece of evidence states: 'we provide evidence that CD160-TM represents a novel activating receptor, as assessed by the increased CD107a NK cell surface mobilization observed upon its engagement.' This evidence highlights a mech... | natural killer cell degranulation | Medium | convergence | {"qa_id":"medium_convergence_04073","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CD160 and AP1G1 are both associated with multiple shared biological processes. One specific piece of evidence states: 'we provide evidence that CD160-TM repr... | |
medium_convergence_04074 | MDM2 and ANLN both interact with a shared ribosomal protein. Evidence indicates that this shared protein binds to a specific ribosomal protein and drives its polyubiquitylation and proteasomal degradation. Which protein is encoded by this shared entity? | Large ribosomal subunit protein uL24 | Medium | convergence | {"qa_id":"medium_convergence_04074","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and ANLN both interact with a shared ribosomal protein. Evidence indicates that this shared protein binds to a specific ribosomal protein and drives its... |
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