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medium_convergence_00638 | MYD88 and CD36 share common interaction partners. One such shared partner is known to form homodimers and heterodimers with MyD88. Which protein is encoded by this shared partner? | Toll/interleukin-1 receptor domain-containing adapter protein | Medium | convergence | {"qa_id":"medium_convergence_00638","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYD88 and CD36 share common interaction partners. One such shared partner is known to form homodimers and heterodimers with MyD88. Which protein is encoded b... | |
medium_convergence_00640 | GABARAPL2 and MAP1LC3C share interaction partners. One such shared partner is characterized by evidence stating it binds ATG8 family proteins, with a preference for LC3C, and directly interacts with SOD1. Which protein is encoded by this shared partner? | Tumor protein p53-inducible nuclear protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00640","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GABARAPL2 and MAP1LC3C share interaction partners. One such shared partner is characterized by evidence stating it binds ATG8 family proteins, with a prefere... | |
medium_convergence_00642 | CTNNB1 and RICTOR share common interacting partners. One such shared partner is implicated in evidence stating that IKKalpha and a specific kinase subunit interact with and phosphorylate beta-catenin in both in vitro and in vivo assays. Which protein is encoded by this shared interacting partner? | Inhibitor of nuclear factor kappa-B kinase subunit beta | Medium | convergence | {"qa_id":"medium_convergence_00642","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and RICTOR share common interacting partners. One such shared partner is implicated in evidence stating that IKKalpha and a specific kinase subunit in... | |
medium_convergence_00643 | Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.268 and an adjusted p-value of 0.003694. In which cell type is this gene enriched? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_00643","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114... | |
medium_convergence_00645 | BMPR2 and ACVR2B each interact with a shared protein partner. For one of these shared partners, evidence indicates that PINCH-1 interacts with it, thereby inhibiting its interaction with BMPR2 and consequently suppressing the degradation of BMPR2. Which protein is encoded by the gene corresponding to this shared partne... | E3 ubiquitin-protein ligase SMURF1 | Medium | convergence | {"qa_id":"medium_convergence_00645","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMPR2 and ACVR2B each interact with a shared protein partner. For one of these shared partners, evidence indicates that PINCH-1 interacts with it, thereby in... | |
medium_convergence_00646 | COPS5 and HSPA1A share multiple interacting partners. One of these shared partners is characterized by experimental evidence showing that its SH3 domain directly binds to the MPN domain of COPS5, as demonstrated by a GST pull-down assay. Which disease is associated with this specific shared partner? | acute myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_00646","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and HSPA1A share multiple interacting partners. One of these shared partners is characterized by experimental evidence showing that its SH3 domain dire... | |
medium_convergence_00647 | CDC37 and CTNNB1 share multiple interaction partners. One such partner is implicated in evidence stating that an N-terminal fragment of a specific spectrin-repeat protein was sufficient for cell-cell junction localization and interacted with β-catenin. Which cell type is this specific partner enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_00647","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and CTNNB1 share multiple interaction partners. One such partner is implicated in evidence stating that an N-terminal fragment of a specific spectrin-r... | |
medium_convergence_00648 | ARPC3 and AP2S1 both interact with a shared protein partner. Evidence indicates that the NTA region of this partner interacts directly with the Arp2/3 complex, as demonstrated by affinity chromatography, immunoprecipitation assays, and binding assays using purified components. Which cell type is this shared protein par... | peripheral blood mononuclear cell | Medium | convergence | {"qa_id":"medium_convergence_00648","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC3 and AP2S1 both interact with a shared protein partner. Evidence indicates that the NTA region of this partner interacts directly with the Arp2/3 comple... | |
medium_convergence_00649 | GNB1 and BDKRB2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that Gbetagamma dimers containing Gbeta(1-4) complexed with gamma(2) stimulated P-Rex1 activity with EC(50) values ranging from 10 to 20 nm. Which protein is connected to that specific sha... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | Medium | convergence | {"qa_id":"medium_convergence_00649","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNB1 and BDKRB2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that Gbetagamma dimers co... | |
medium_convergence_00650 | GTF3C1 and GTF3C4 share multiple binding partners. One such shared partner is described by evidence stating: 'Furthermore, a specific TFIIIC subunit specifically interacts with the human TFIIIC subunits TFIIIC63 and, to a lesser extent, TFIIIC90 in vitro.' Which cell type is this specific shared partner enriched in? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_00650","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF3C1 and GTF3C4 share multiple binding partners. One such shared partner is described by evidence stating: 'Furthermore, a specific TFIIIC subunit specific... | |
medium_convergence_00651 | JMJD6 and USP7 share multiple interacting partners. One such shared partner is described in evidence stating: 'This confirmed reported associations of USP7 with USP11, PPM1G phosphatase and TRIP12 E3 ubiquitin ligase as well as identifying novel interactions with two DEAD/DEAH-box RNA helicases, DDX24 and this shared p... | Probable ATP-dependent RNA helicase DHX40 | Medium | convergence | {"qa_id":"medium_convergence_00651","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JMJD6 and USP7 share multiple interacting partners. One such shared partner is described in evidence stating: 'This confirmed reported associations of USP7 w... | |
medium_convergence_00652 | Both INS and INSR interact with multiple shared partners. One such partner is distinguished by the fact that its protein product, IRS-2, contains an interaction domain spanning residues 591 to 786, a feature absent in IRS-1. Which gene encodes this specific protein? | Insulin receptor substrate 2 | Medium | convergence | {"qa_id":"medium_convergence_00652","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both INS and INSR interact with multiple shared partners. One such partner is distinguished by the fact that its protein product, IRS-2, contains an interact... | |
medium_convergence_00654 | COPS5 and CTBP2 both interact with a shared protein. Evidence regarding this shared protein states: 'The novel Bcl-3 interactors Jab1, Pirin, Tip60 and Bard1 are nuclear proteins which also bind to other transcription factors including c-Jun, nuclear factor I (NFI), HIV-1 Tat or the tumor suppressor and PolII holoenzym... | B-cell lymphoma 3 protein | Medium | convergence | {"qa_id":"medium_convergence_00654","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and CTBP2 both interact with a shared protein. Evidence regarding this shared protein states: 'The novel Bcl-3 interactors Jab1, Pirin, Tip60 and Bard1... | |
medium_convergence_00655 | MED1 and NCOR1 both interact with a specific nuclear receptor. Evidence regarding this receptor indicates that TRAP220 and TRAP100 contain LXXLL domains, are found in other nuclear receptor-interacting proteins, and reside in a single complex with other TRAPs (in the absence of TR). Which protein is encoded by this nuc... | Thyroid hormone receptor alpha | Medium | convergence | {"qa_id":"medium_convergence_00655","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED1 and NCOR1 both interact with a specific nuclear receptor. Evidence regarding this receptor indicates that TRAP220 and TRAP100 contain LXXLL domains, are... | |
medium_convergence_00656 | MECOM and MYC both interact with a shared protein. Evidence indicates that Evi1 (the protein product of MECOM) interacts with this specific entity, but not with other MBD family members such as Mbd1, Mbd2, Mbd4, or MeCP2. Which disease is associated with this entity as a biomarker? | autism spectrum disorder | Medium | convergence | {"qa_id":"medium_convergence_00656","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MECOM and MYC both interact with a shared protein. Evidence indicates that Evi1 (the protein product of MECOM) interacts with this specific entity, but not w... | |
medium_convergence_00658 | EP300 and SIRT1 share multiple interacting partners. One such partner is implicated in evidence stating that non-phosphorylatable p300 (S106A) destabilized this partner and decreased the interaction between this partner and p300. Which cell type is this specific partner enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_00658","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and SIRT1 share multiple interacting partners. One such partner is implicated in evidence stating that non-phosphorylatable p300 (S106A) destabilized t... | |
medium_convergence_00659 | KRT8 and KRT15 both interact with a specific protein. Experimental evidence from two-hybrid assays indicates that this protein interacts significantly with K16 and K18, and to some extent with K5, K6a, K8, and K14. Which protein is encoded by the gene corresponding to this interacting partner? | Trichoplein keratin filament-binding protein | Medium | convergence | {"qa_id":"medium_convergence_00659","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRT8 and KRT15 both interact with a specific protein. Experimental evidence from two-hybrid assays indicates that this protein interacts significantly with K... | |
medium_convergence_00660 | CEP164 and CLSPN both interact with a shared protein partner. Evidence indicates that TRIM21-mediated K63-linked ubiquitination of CLASPIN counteracts K6-linked ubiquitination of CLASPIN, a process essential for CLASPIN's interaction with this shared partner and its subsequent chromatin loading. Which protein is encode... | TIMELESS-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_00660","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEP164 and CLSPN both interact with a shared protein partner. Evidence indicates that TRIM21-mediated K63-linked ubiquitination of CLASPIN counteracts K6-lin... | |
medium_convergence_00661 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.187 and an adjusted p-value of 0.002873. Which protein is encoded by this gene? | GTP-binding protein RAD | Medium | convergence | {"qa_id":"medium_convergence_00661","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (stud... | |
medium_convergence_00662 | AKAP9 and MAPRE1 both interact with a shared protein. Evidence indicates that this shared protein, also known as CG-NAP, contains two sets of putative RII (regulatory subunit of protein kinase A)-binding motifs and tightly binds to RIIalpha in HeLa cells. Which protein is encoded by this shared entity? | cAMP-dependent protein kinase type II-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_00662","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP9 and MAPRE1 both interact with a shared protein. Evidence indicates that this shared protein, also known as CG-NAP, contains two sets of putative RII (r... | |
medium_convergence_00663 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Evidence for this gene's upregulation in a retinal pigment epithelium cell line reports a log2 fold change of approximately 2.88 and an adjusted p-value of approximately 0.00016. Which disease is genetically associated with this gene? | acidosis disorder | Medium | convergence | {"qa_id":"medium_convergence_00663","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Evidence for this gene's upregulation in a retinal pigment epithelium cell line rep... | |
medium_convergence_00664 | NFKB1 and BTRC share multiple binding partners. One such shared partner is described as interacting with various NF-kappaB proteins, including p65, c-Rel, p50, and p52, both in vitro and in vivo. This interaction effectively inhibits the DNA-binding activity of p50-p65 and p50-c-Rel complexes. Which disease is associat... | follicular lymphoma | Medium | convergence | {"qa_id":"medium_convergence_00664","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFKB1 and BTRC share multiple binding partners. One such shared partner is described as interacting with various NF-kappaB proteins, including p65, c-Rel, p5... | |
medium_convergence_00666 | Both Orthohepevirus A and Human gammaherpesvirus 8 are known to downregulate a specific gene. In a study of hepatocytes (GSE135619), this gene was found to have a log2 fold change of -1.524 and an adjusted p-value of 0.02309. Which protein does this gene interact with? | TP53BP2 | Medium | convergence | {"qa_id":"medium_convergence_00666","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Human gammaherpesvirus 8 are known to downregulate a specific gene. In a study of hepatocytes (GSE135619), this gene was found to h... | |
medium_convergence_00667 | BRD4 and HIF1A share multiple interacting partners. One such shared partner is implicated in a study demonstrating that multiple MCM proteins bind directly to the HIF-1α subunit and synergistically inhibit HIF-1 transcriptional activity via distinct O(2)-dependent mechanisms. Which protein is connected to this shared p... | DNA replication licensing factor MCM7 | Medium | convergence | {"qa_id":"medium_convergence_00667","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and HIF1A share multiple interacting partners. One such shared partner is implicated in a study demonstrating that multiple MCM proteins bind directly t... | |
medium_convergence_00668 | FBXW11 and NFKB1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Cotransfection experiments demonstrated that a TNIP2 isoform could interact with TPL-2 in addition to p105 but preferentially formed a ternary complex with both proteins.' Which disease is associated with t... | endometrial carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00668","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and NFKB1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Cotransfection experiments demonstrated tha... | |
medium_convergence_00669 | U2AF2 and AR both interact with a shared protein. Evidence indicates that this shared protein directly associates with AR. Which protein is encoded by this shared entity? | ATP-dependent chromatin remodeler CHD8 | Medium | convergence | {"qa_id":"medium_convergence_00669","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"U2AF2 and AR both interact with a shared protein. Evidence indicates that this shared protein directly associates with AR. Which protein is encoded by this s... | |
medium_convergence_00670 | AKT1 and AKT2 each interact with multiple shared partners. One such partner is described as disrupting insulin signaling by binding directly to Akt and blocking kinase activation. Which disease is associated with this specific partner? | thymoma | Medium | convergence | {"qa_id":"medium_convergence_00670","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and AKT2 each interact with multiple shared partners. One such partner is described as disrupting insulin signaling by binding directly to Akt and block... | |
medium_convergence_00671 | Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific gene. Experimental data from a study on macrophages (GSE108897) indicates that this gene has a log2 fold change of -1.963 and an adjusted p-value of 1.658e-05. What molecular function is enabled by this gene? | structural constituent of cytoskeleton | Medium | convergence | {"qa_id":"medium_convergence_00671","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific gene. Experimental data from a study on macrophages (GSE108897) indicates that t... | |
medium_convergence_00672 | APAF1 and CASP9 each interact with more than one shared gene product. Evidence concerning one shared entity reports that a cytochrome protein binds to Apaf-1, an event that may trigger the activation of caspase-3, leading to apoptosis. Which disease is connected to that entity through a protective relationship? | colitis | Medium | convergence | {"qa_id":"medium_convergence_00672","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"APAF1 and CASP9 each interact with more than one shared gene product. Evidence concerning one shared entity reports that a cytochrome protein binds to Apaf-1... | |
medium_convergence_00673 | Measles morbillivirus and Rift Valley fever phlebovirus both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of 2.284 and an adjusted p-value of 0.03663. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_00673","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Rift Valley fever phlebovirus both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold cha... | |
medium_convergence_00675 | PAXIP1 and HERC2 both interact with a common protein partner. Evidence indicates that this partner, identified as hPTIP, exhibits increased association with a DNA damage response protein specifically in response to ionizing radiation, but not to other DNA-damaging agents. Which disease is linked to this protein partner... | glioblastoma | Medium | convergence | {"qa_id":"medium_convergence_00675","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PAXIP1 and HERC2 both interact with a common protein partner. Evidence indicates that this partner, identified as hPTIP, exhibits increased association with ... | |
medium_convergence_00676 | RRAGA and ATP6V0D1 both interact with a specific shared protein. Evidence describes this shared entity as an uncharacterized protein with sequence similarity to amino acid transporters, identified as a lysosomal transmembrane protein that interacts with Rag GTPases and Ragulator in an amino acid-sensitive manner. Which... | Neutral amino acid transporter 9 | Medium | convergence | {"qa_id":"medium_convergence_00676","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RRAGA and ATP6V0D1 both interact with a specific shared protein. Evidence describes this shared entity as an uncharacterized protein with sequence similarity... | |
medium_convergence_00677 | DLG4 and YWHAE both interact with a shared protein entity. Evidence regarding this entity states: 'Here, we describe the isolation of a novel Ras-GTPase activating protein, [ENTITY], that interacts with the PDZ domains of PSD-95 and SAP102 in vitro and in vivo.' Which protein is connected to this entity through the 'en... | Ras/Rap GTPase-activating protein SynGAP | Medium | convergence | {"qa_id":"medium_convergence_00677","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG4 and YWHAE both interact with a shared protein entity. Evidence regarding this entity states: 'Here, we describe the isolation of a novel Ras-GTPase acti... | |
medium_convergence_00678 | CREBBP and JAG2 both interact with a specific receptor protein. Experimental evidence indicates that three DSL family proteins bind to this endogenous receptor on the surface of BaF3 cells, with Jagged2 exhibiting distinct binding characteristics compared to Delta1 and Jagged1. Which protein is encoded by the gene corr... | Neurogenic locus notch homolog protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00678","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and JAG2 both interact with a specific receptor protein. Experimental evidence indicates that three DSL family proteins bind to this endogenous recept... | |
medium_convergence_00679 | IL12B and VSIR are both involved in more than one shared biological process. One shared process is supported by evidence stating: 'In contrast, IL-12 mediated specific inhibition of IL-17 production.' Which biological process is connected to this entity through the relation 'negatively regulates'? | interleukin-17 production | Medium | convergence | {"qa_id":"medium_convergence_00679","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL12B and VSIR are both involved in more than one shared biological process. One shared process is supported by evidence stating: 'In contrast, IL-12 mediate... | |
medium_convergence_00680 | ARMC8 and MKLN1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Immunoprecipitation and gel-filtration analyses indicated that both Twa1 and hMuskelin did indeed comprise a protein complex with the protein encoded by this shared entity.' Which protein is encoded ... | Ran-binding protein 9 | Medium | convergence | {"qa_id":"medium_convergence_00680","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARMC8 and MKLN1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Immunoprecipitation and gel-filtrati... | |
medium_convergence_00681 | Human mastadenovirus C and Primate bocaparvovirus 1 are both reported to upregulate a specific gene. Experimental data for this gene in lung fibroblast cell lines (study GSE120891) indicates a log2 fold change of approximately 2.775 and an adjusted p-value of 0.04181. Which protein is encoded by this gene? | TNF receptor-associated factor 1 | Medium | convergence | {"qa_id":"medium_convergence_00681","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human mastadenovirus C and Primate bocaparvovirus 1 are both reported to upregulate a specific gene. Experimental data for this gene in lung fibroblast cell ... | |
medium_convergence_00682 | NCBP2 and PPP2CA both interact with a shared protein partner. Evidence regarding this partner notes that 'Similar chromatographic profiles were also observed for the heterotrimer reconstituted from recombinant A alpha, purified B and C, and the native bovine cardiac heterotrimeric holoenzyme.' Which disease is associat... | biliary atresia | Medium | convergence | {"qa_id":"medium_convergence_00682","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCBP2 and PPP2CA both interact with a shared protein partner. Evidence regarding this partner notes that 'Similar chromatographic profiles were also observed... | |
medium_convergence_00684 | KPNB1 and MAGOH both interact with a shared nucleoporin. Experimental evidence indicates that the importin beta transport complex binds to nucleoporins with progressively increasing affinity as it moves from Nup358 to this specific entity and to Nup153. Which disease is associated with this entity? | familial infantile bilateral striatal necrosis | Medium | convergence | {"qa_id":"medium_convergence_00684","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KPNB1 and MAGOH both interact with a shared nucleoporin. Experimental evidence indicates that the importin beta transport complex binds to nucleoporins with ... | |
medium_convergence_00685 | Influenza A virus and Pegivirus C both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of approximately 1.04 and an adjusted p-value of 0.00151. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_00685","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Influenza A virus and Pegivirus C both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of approximately 1.04 and an ad... | |
medium_convergence_00686 | COPS4 and CUL4A share a common binding partner. Evidence indicates that the UV-DDB complex consists of this shared entity and another protein, and that this complex functions as a component of the cullin 4A-based ubiquitin ligase. Which protein is encoded by this shared entity? | DNA damage-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00686","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS4 and CUL4A share a common binding partner. Evidence indicates that the UV-DDB complex consists of this shared entity and another protein, and that this ... | |
medium_convergence_00687 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of -1.023 and an adjusted p-value of 0.0001724. Which disease is causally linked to thi... | rectum adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00687","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for t... | |
medium_convergence_00688 | DCUN1D3 and CUL1 both interact with a shared protein partner. Evidence for this interaction states: 'This is validated by co-immunoprecipitation experiments from cells expressing the mutant protein and from human heart tissue from two of the affected patients.' Which protein is encoded by this shared partner? | F-box only protein 32 | Medium | convergence | {"qa_id":"medium_convergence_00688","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCUN1D3 and CUL1 both interact with a shared protein partner. Evidence for this interaction states: 'This is validated by co-immunoprecipitation experiments ... | |
medium_convergence_00690 | UBE2D1 and UBE2D2 both interact with a shared protein. Evidence indicates that this shared protein is an E3 ligase that can be loaded with ubiquitin from the E2 enzyme UBE2D2. Which cell type is this shared protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_00690","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBE2D1 and UBE2D2 both interact with a shared protein. Evidence indicates that this shared protein is an E3 ligase that can be loaded with ubiquitin from the... | |
medium_convergence_00691 | CSNK2B and PCGF2 both interact with a shared protein partner. Biochemical evidence indicates that this partner, or its homolog YAF2, associates with PCGF-RING1A/B combinations to form complexes that prevent the incorporation of canonical PRC1 subunits such as CBX, PHC, and SCM. Which protein is encoded by the gene corr... | RING1 and YY1-binding protein | Medium | convergence | {"qa_id":"medium_convergence_00691","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and PCGF2 both interact with a shared protein partner. Biochemical evidence indicates that this partner, or its homolog YAF2, associates with PCGF-RIN... | |
medium_convergence_00693 | COPS5 and COPS2 both interact with a shared protein partner. Evidence regarding this partner states: 'We demonstrated that the C-terminal half of the subunit encoded by the gene corresponding to this shared partner encompassing the PCI domain is responsible for interaction with CSN2, CSN3, and CSN4 subunits and is requ... | COP9 signalosome complex subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_00693","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and COPS2 both interact with a shared protein partner. Evidence regarding this partner states: 'We demonstrated that the C-terminal half of the subunit... | |
medium_convergence_00694 | AMOT and GSK3B share interaction partners. One shared partner was identified using human glycogen synthase kinase 3beta (GSK-3beta) as bait in a yeast two-hybrid system, revealing a novel human centrosome-associated protein. Which protein is encoded by this shared partner? | Ninein | Medium | convergence | {"qa_id":"medium_convergence_00694","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMOT and GSK3B share interaction partners. One shared partner was identified using human glycogen synthase kinase 3beta (GSK-3beta) as bait in a yeast two-hy... | |
medium_convergence_00695 | ASF1A and ASF1B both interact with a shared protein entity. Evidence indicates that hAsf1 proteins interact directly with the p60 subunit of hCAF-1. Which disease is associated with this shared entity via a biomarker relationship? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_00695","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ASF1A and ASF1B both interact with a shared protein entity. Evidence indicates that hAsf1 proteins interact directly with the p60 subunit of hCAF-1. Which di... | |
medium_convergence_00696 | DNMT1 and NCOR1 both interact with a shared protein. Evidence indicates that this shared protein also binds the N-CoR corepressor and is required for N-CoR-mediated repression by antagonist-bound estrogen receptor and the homeodomain protein Rpx, as well as N-CoR suppression of transactivation by the POU domain protein... | Histone deacetylase complex subunit SAP30 | Medium | convergence | {"qa_id":"medium_convergence_00696","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT1 and NCOR1 both interact with a shared protein. Evidence indicates that this shared protein also binds the N-CoR corepressor and is required for N-CoR-m... | |
medium_convergence_00697 | ANAPC16 and ANAPC5 both interact with a common protein partner. Structural and biochemical evidence indicates that this partner is recruited to the APC3 dimer by APC16. Which disease is associated with this specific protein partner? | Ferguson-Bonni neurodevelopmental syndrome | Medium | convergence | {"qa_id":"medium_convergence_00697","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC16 and ANAPC5 both interact with a common protein partner. Structural and biochemical evidence indicates that this partner is recruited to the APC3 dime... | |
medium_convergence_00698 | Both Vaccinia virus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.088 and an adjusted p-value of 0.03641. Which disease is associated with this gene as a bioma... | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_00698","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinoma cell... | |
medium_convergence_00699 | The biological processes 'positive regulation of RNA import into nucleus' and 'positive regulation of RNA export from nucleus' share a common parent process. Evidence regarding one of the shared entities states: 'Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm... | nucleocytoplasmic transport | Medium | convergence | {"qa_id":"medium_convergence_00699","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'positive regulation of RNA import into nucleus' and 'positive regulation of RNA export from nucleus' share a common parent process.... | |
medium_convergence_00700 | KLHDC2 and KPNB1 both interact with a common protein partner. Research evidence describes the crystal structures of KLHDC2, acting as a CRL2 substrate receptor, in complex with the diglycine-ending C-end degrons of two early-terminated selenoproteins and the N-terminal proteolytic fragment of this shared partner. Which... | Ubiquitin carboxyl-terminal hydrolase 1 | Medium | convergence | {"qa_id":"medium_convergence_00700","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KLHDC2 and KPNB1 both interact with a common protein partner. Research evidence describes the crystal structures of KLHDC2, acting as a CRL2 substrate recept... | |
medium_convergence_00701 | Human alphaherpesvirus 3 and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.182 and an adjusted p-value of 3.76e-08. Which biological process is this gene involved in? | protein O-linked glycosylation via glucose | Medium | convergence | {"qa_id":"medium_convergence_00701","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) repor... | |
medium_convergence_00702 | RAD50 and ATM both interact with a shared protein. Evidence regarding this protein states: 'This effect is dependent on a direct interaction between MRN and the tandem breast cancer carboxy-terminal (BRCT) repeats in this protein, and is accompanied by hyper-phosphorylation of both Nbs1 and this protein.' Which disease... | lupus vulgaris | Medium | convergence | {"qa_id":"medium_convergence_00702","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD50 and ATM both interact with a shared protein. Evidence regarding this protein states: 'This effect is dependent on a direct interaction between MRN and ... | |
medium_convergence_00703 | Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately -5.005 and an adjusted p-value of 0.02592. Which disease is associated with this gene as a biomarke... | cervical cancer | Medium | convergence | {"qa_id":"medium_convergence_00703","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene in macrophages (fr... | |
medium_convergence_00704 | Neuromedin U (NMU) and Neuromedin S (NMS) both interact with a specific receptor protein. Experimental evidence indicates that radiolabeled neuromedin U binds with high affinity to membrane fractions prepared from cells expressing this receptor. Which protein is encoded by the gene corresponding to this receptor? | Neuromedin-U receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_00704","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Neuromedin U (NMU) and Neuromedin S (NMS) both interact with a specific receptor protein. Experimental evidence indicates that radiolabeled neuromedin U bind... | |
medium_convergence_00705 | KPNA1 and MYC share multiple interacting partners. One such shared partner is characterized by evidence indicating that its N-terminal region directly binds karyopherin αs, rather than karyopherin β. Which protein is encoded by this specific shared partner? | Beta-catenin-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00705","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KPNA1 and MYC share multiple interacting partners. One such shared partner is characterized by evidence indicating that its N-terminal region directly binds ... | |
medium_convergence_00706 | POLR1A and POLR1E each share a binding partner with another gene. Evidence concerning one such shared partner indicates that a protein was shown to interact with PAF53 through its N-terminal segment. Which protein is encoded by that shared partner? | DNA-directed RNA polymerase I subunit RPA34 | Medium | convergence | {"qa_id":"medium_convergence_00706","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLR1A and POLR1E each share a binding partner with another gene. Evidence concerning one such shared partner indicates that a protein was shown to interact ... | |
medium_convergence_00707 | CCL4 and LAMTOR3 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In a two-hybrid screen with p14 as a bait, we identified the mitogen-activated protein kinase (MAPK) scaffolding protein MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) partner 1 (MP1) as an i... | Dual specificity mitogen-activated protein kinase kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_00707","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCL4 and LAMTOR3 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In a two-hybrid screen with p14 as a bait, ... | |
medium_convergence_00708 | PLK1 and AKIRIN2 share common interaction partners. One such shared partner is implicated in evidence stating that Immunoprecipitation and mass spectrometry (IP-MS) studies identified numerous proteins interacting with phosphorylated α5, including PLK1, a key regulator of mitosis. Which protein is encoded by this share... | Proteasome subunit alpha type-5 | Medium | convergence | {"qa_id":"medium_convergence_00708","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PLK1 and AKIRIN2 share common interaction partners. One such shared partner is implicated in evidence stating that Immunoprecipitation and mass spectrometry ... | |
medium_convergence_00710 | VPS11 and VPS18 both interact with a specific protein that functions as a Beclin1-binding autophagic tumor suppressor and interacts with the class C Vps complex, a key component of the endosomal fusion machinery. Which protein is encoded by this gene? | UV radiation resistance-associated gene protein | Medium | convergence | {"qa_id":"medium_convergence_00710","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS11 and VPS18 both interact with a specific protein that functions as a Beclin1-binding autophagic tumor suppressor and interacts with the class C Vps comp... | |
medium_convergence_00711 | HIF1A and ARF1 both interact with a specific phospholipase D isoform. Evidence indicates that this protein acts as a molecular platform, interacting directly with HIF-1α, PHD, and VHL to mediate the efficient, O2-dependent degradation of HIF-1α. Which gene encodes this protein? | Phospholipase D1 | Medium | convergence | {"qa_id":"medium_convergence_00711","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIF1A and ARF1 both interact with a specific phospholipase D isoform. Evidence indicates that this protein acts as a molecular platform, interacting directly... | |
medium_convergence_00712 | DAG1 and DTNA both interact with a shared protein partner. Contextual evidence specifies that dystrobrevin binds directly to the syntrophins, a group of dystrophin-associated proteins. Which protein, encoded by the gene corresponding to this shared partner, is the target of the 'encodes' relationship? | Alpha-1-syntrophin | Medium | convergence | {"qa_id":"medium_convergence_00712","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAG1 and DTNA both interact with a shared protein partner. Contextual evidence specifies that dystrobrevin binds directly to the syntrophins, a group of dyst... | |
medium_convergence_00714 | CDKN2A and MDM2 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here we demonstrate a novel p53-independent interaction between the nucleolar tumor suppressors, p14 Arf and Werners helicase.' Which protein is connected to that entity through the 'encodes' relationsh... | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_00714","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN2A and MDM2 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here we demonstrate a novel p53-indepen... | |
medium_convergence_00715 | PARP1 and RHOA share common interacting partners. One such partner is described as a HECT-type E3 ubiquitin ligase and a suggested tumor suppressor that physically interacts with PARP1, directly ubiquitinates it in vitro, and stimulates its PARylation activity in cells, a process requiring the partner's E3 ligase funct... | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_00715","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and RHOA share common interacting partners. One such partner is described as a HECT-type E3 ubiquitin ligase and a suggested tumor suppressor that phys... | |
medium_convergence_00716 | KCNE1 and KCNQ1 both enable a shared molecular function. Evidence indicates that one of these shared functions involves KCNE1 encoding beta-subunits (hminK) that co-assemble with KvLQT1 alpha-subunits to form the slowly activating delayed rectifier K+ (IKs) channel. Which biological process is connected to this specifi... | membrane repolarization during ventricular cardiac muscle cell action potential | Medium | convergence | {"qa_id":"medium_convergence_00716","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNE1 and KCNQ1 both enable a shared molecular function. Evidence indicates that one of these shared functions involves KCNE1 encoding beta-subunits (hminK) ... | |
medium_convergence_00717 | FBXW11 and GSK3B both interact with a shared protein entity. Evidence regarding this entity states: 'Here, two-dimensional (2D) gel electrophoresis and site-directed mutagenesis allowed us to identify two serines of the target protein that are phosphorylated by glycogen synthase kinase 3β (GSK-3β) in the sequence DSGIS... | Nuclear factor erythroid 2-related factor 2 | Medium | convergence | {"qa_id":"medium_convergence_00717","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and GSK3B both interact with a shared protein entity. Evidence regarding this entity states: 'Here, two-dimensional (2D) gel electrophoresis and site-... | |
medium_convergence_00718 | COPB1 and ANK2 both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which cellular component is this shared partner ... | Golgi membrane | Medium | convergence | {"qa_id":"medium_convergence_00718","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and ANK2 both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer... | |
medium_convergence_00719 | Zaire ebolavirus and Primate bocaparvovirus 1 both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839) shows a log2 fold change of -2.656 and an adjusted p-value of 0.0009316. Which protein is encoded by this gene? | Protein c-Fos | Medium | convergence | {"qa_id":"medium_convergence_00719","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Primate bocaparvovirus 1 both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (s... | |
medium_convergence_00720 | DAP3 and CASP8 both interact with a shared protein entity. Evidence regarding this entity states: 'We have found that the GTP-binding protein [this entity] binds directly (with high affinity) to the death domain of TNF-related apoptosis-inducing ligand (TRAIL) receptors, and is required for TRAIL-induced apoptosis.' Wh... | Tumor necrosis factor receptor superfamily member 10A | Medium | convergence | {"qa_id":"medium_convergence_00720","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAP3 and CASP8 both interact with a shared protein entity. Evidence regarding this entity states: 'We have found that the GTP-binding protein [this entity] b... | |
medium_convergence_00721 | POLR3B and GTF3C4 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports: 'These include novel interactions of hTFIIIC63 with hTFIIIC102, with hTFIIIB90, and with hRPC62, in addition to the hTFIIIC102-hTFIIIB90 and hTFIIIB90-hRPC39 interactions that parallel the pre... | DNA-directed RNA polymerase III subunit RPC3 | Medium | convergence | {"qa_id":"medium_convergence_00721","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLR3B and GTF3C4 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports: 'These include novel interact... | |
medium_convergence_00722 | RARG and NCOA1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'As anticipated from its location, the L454S mutant interacts weakly with CoAs, such as SRC1 and glucocorticoid receptor interacting protein 1 (GRIP1) in gel mobility shift assays and in mammalian... | Thyroid hormone receptor alpha | Medium | convergence | {"qa_id":"medium_convergence_00722","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RARG and NCOA1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'As anticipated from its location... | |
medium_convergence_00723 | ERBB2 and PLXNB1 share a common binding partner. Evidence indicates that this shared entity is a member of the Rho family GTPases and directly interacts with the cytoplasmic domain of Plexin-B1. Which protein is encoded by this shared entity? | Rho-related GTP-binding protein Rho6 | Medium | convergence | {"qa_id":"medium_convergence_00723","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and PLXNB1 share a common binding partner. Evidence indicates that this shared entity is a member of the Rho family GTPases and directly interacts with... | |
medium_convergence_00724 | Both MCM9 and MCM2 interact with a shared protein partner. Experimental evidence indicates that this partner, when co-expressed in insect cells, interacts with individual MCM proteins 2 through 7 and significantly enhances the recovery of certain recombinant MCM proteins. Which protein is encoded by the gene correspond... | Mini-chromosome maintenance complex-binding protein | Medium | convergence | {"qa_id":"medium_convergence_00724","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both MCM9 and MCM2 interact with a shared protein partner. Experimental evidence indicates that this partner, when co-expressed in insect cells, interacts wi... | |
medium_convergence_00725 | CDK4 and CASP10 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Fluorescent resonance energy transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of this protein.' Which protein is encoded by that e... | FAS-associated death domain protein | Medium | convergence | {"qa_id":"medium_convergence_00725","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK4 and CASP10 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Fluorescent resonance energy transfer analys... | |
medium_convergence_00726 | Measles morbillivirus and Cardiovirus A both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of -1.128 and an adjusted p-value of 0.03561. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_00726","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Cardiovirus A both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of -1.128 and an adjusted... | |
medium_convergence_00727 | GFRA1 and GFRA3 both interact with a specific protein. Evidence indicates that NTN, in the presence of NTNR-alpha, induces tyrosine-phosphorylation of this protein, and that NTN, NTNR-alpha, and this protein form a physical complex on the cell surface. Which protein is encoded by the gene corresponding to this entity? | Proto-oncogene tyrosine-protein kinase receptor Ret | Medium | convergence | {"qa_id":"medium_convergence_00727","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GFRA1 and GFRA3 both interact with a specific protein. Evidence indicates that NTN, in the presence of NTNR-alpha, induces tyrosine-phosphorylation of this p... | |
medium_convergence_00728 | LIN54 and E2F5 share multiple binding partners. One such shared partner is a component of the DREAM complex, which is described as containing mammalian homologs of synMuvB proteins including LIN-9, LIN-37, LIN-52, LIN-54, and LIN-53/RBBP4. Which protein is encoded by the gene corresponding to this shared partner? | Retinoblastoma-like protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00728","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LIN54 and E2F5 share multiple binding partners. One such shared partner is a component of the DREAM complex, which is described as containing mammalian homol... | |
medium_convergence_00729 | Both IKBKB and IKBKG interact with a common protein partner. Contextual evidence describes this partner as a RICK-related kinase that associates with IKKgamma via its intermediate region. Which cell type is this protein partner enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_00729","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKB and IKBKG interact with a common protein partner. Contextual evidence describes this partner as a RICK-related kinase that associates with IKKgamm... | |
medium_convergence_00730 | PRNP and BAG6 both interact with a shared protein. Evidence regarding this shared entity states: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified as novel interaction partners while interaction with Hsc70 was confirmed.' Which disease is associated with this shared protein? | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_00730","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRNP and BAG6 both interact with a shared protein. Evidence regarding this shared entity states: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified as no... | |
medium_convergence_00731 | Cardiovirus A and Zika virus both upregulate a specific gene in cervical adenocarcinoma cells. Experimental data for this gene shows a log2 fold change of approximately 1.209 and an adjusted p-value of 0.009975. Which protein is encoded by this gene? | CCN family member 2 | Medium | convergence | {"qa_id":"medium_convergence_00731","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cardiovirus A and Zika virus both upregulate a specific gene in cervical adenocarcinoma cells. Experimental data for this gene shows a log2 fold change of ap... | |
medium_convergence_00732 | CLTA and PRKN each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here, we investigate the role of the endosomal adaptor this entity during the mitochondrial stress response and identify its interaction and colocalisation with the Parkinson's disease-associated E3 ubiqu... | Toll-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_00732","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLTA and PRKN each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here, we investigate the role of the endo... | |
medium_convergence_00733 | YWHAQ and ATG16L1 share a common interaction partner. Evidence regarding this shared partner states: 'We established that ATG16L1 binds to the kinase domain of this shared partner and negatively regulates TLR2-mediated nuclear factor-kappa B (NF-κB) activation and pro-inflammatory cytokine responses by inhibiting the i... | Receptor-interacting serine/threonine-protein kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_00733","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and ATG16L1 share a common interaction partner. Evidence regarding this shared partner states: 'We established that ATG16L1 binds to the kinase domain ... | |
medium_convergence_00734 | BICD2 and PRKN (PARK2) share common interaction partners. Evidence regarding one specific shared partner indicates that a mutant form of BICD2 (R747C) was deficient in binding to HOPS complex components and to this specific nucleoporin. Which protein is encoded by this shared interaction partner? | E3 SUMO-protein ligase RanBP2 | Medium | convergence | {"qa_id":"medium_convergence_00734","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BICD2 and PRKN (PARK2) share common interaction partners. Evidence regarding one specific shared partner indicates that a mutant form of BICD2 (R747C) was de... | |
medium_convergence_00735 | AP2A1 and AP2B1 both interact with a shared protein. Evidence indicates that beta2-Adaptin binds this shared protein in a yeast two-hybrid assay and co-immunoprecipitates with it and beta2AR in an agonist-dependent manner in HEK-293 cells. Which cell type is this shared protein enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_00735","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2A1 and AP2B1 both interact with a shared protein. Evidence indicates that beta2-Adaptin binds this shared protein in a yeast two-hybrid assay and co-immun... | |
medium_convergence_00736 | Both Orthohepevirus A and Zika virus downregulate a specific gene in hepatocytes. Experimental data from study GSE135619 indicates that for one such shared target, the log2 fold change is -2.136 and the adjusted p-value is 0.04032. What molecular function is enabled by this specific gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_00736","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Zika virus downregulate a specific gene in hepatocytes. Experimental data from study GSE135619 indicates that for one such shared t... | |
medium_convergence_00737 | CISH and GH1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that CIS and SOCS-2 bound to fusions containing as few as 80 COOH-terminal residues of this entity, provided the fusion protein was tyrosine-phosphorylated. Which disease is connected to this entity throu... | Laron-type isolated somatotropin defect | Medium | convergence | {"qa_id":"medium_convergence_00737","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CISH and GH1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that CIS and SOCS-2 bound to fusions cont... | |
medium_convergence_00738 | Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific gene. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.14 and an adjusted p-value of 0.0038. Which biological process is this gene involved in? | proteasome-mediated ubiquitin-dependent protein catabolic process | Medium | convergence | {"qa_id":"medium_convergence_00738","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific gene. In a study of macrophages (GSE108897), this gene exhibited a log2 fold cha... | |
medium_convergence_00739 | CDH12 and CDH1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'By using the yeast two-hybrid system, we confirmed the direct interaction between CAS and E-cadherin and determined that CAS Arm repeats 1 to 10 are necessary and sufficient for this interaction.' Whi... | Catenin delta-1 | Medium | convergence | {"qa_id":"medium_convergence_00739","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDH12 and CDH1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'By using the yeast two-hybrid system,... | |
medium_convergence_00740 | IL6 and IL12B are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that IL-6 overexpression promoted the proliferation of PBMCs and increased the levels of TNF-α, IL-8, IL-1β, and IL-10. Which biological process, connected to that entity through the r... | interleukin-10 production | Medium | convergence | {"qa_id":"medium_convergence_00740","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL6 and IL12B are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that IL-6 overexpress... | |
medium_convergence_00743 | CTNNB1 and BCL9 both interact with a shared protein. Evidence regarding this shared protein states: 'A crystal structure of beta-catenin bound to the beta-catenin binding domain of a TCF family transcription factor has been determined.' Which cellular component is this shared protein located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00743","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and BCL9 both interact with a shared protein. Evidence regarding this shared protein states: 'A crystal structure of beta-catenin bound to the beta-ca... | |
medium_convergence_00744 | Interferon beta-1a and Methotrexate share a common drug interaction partner. Evidence regarding this shared partner states: 'When these values for Ki obtained with PEN were compared to values obtained with methotrexate and p-aminohippurate, the values of Ki were similar, implying the presence of a similar transport car... | urinary tract infection | Medium | convergence | {"qa_id":"medium_convergence_00744","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interferon beta-1a and Methotrexate share a common drug interaction partner. Evidence regarding this shared partner states: 'When these values for Ki obtaine... | |
medium_convergence_00745 | TRIM28 and LMNA share multiple interaction partners. One such shared partner is implicated in DNA replication, as evidence indicates that KAP1 associates with several DNA replication factors including PCNA, MCM3, and this specific entity. Which protein is encoded by this shared interaction partner? | DNA replication licensing factor MCM6 | Medium | convergence | {"qa_id":"medium_convergence_00745","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and LMNA share multiple interaction partners. One such shared partner is implicated in DNA replication, as evidence indicates that KAP1 associates wit... | |
medium_convergence_00746 | Both Human alphaherpesvirus 1 and Hepacivirus C are reported to downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.953 and an adjusted p-value of 0.001434. What is the protein encoded by this gene? | CCN family member 2 | Medium | convergence | {"qa_id":"medium_convergence_00746","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Hepacivirus C are reported to downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell li... | |
medium_convergence_00747 | VPS28 and UBC each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we show that a regulator of proliferation, hepatocellular carcinoma related protein 1, interacts with Tsg101, hVps28, and their upstream regulator Hrs.' Which disease is connected to that entity through ... | hereditary spastic paraplegia 53 | Medium | convergence | {"qa_id":"medium_convergence_00747","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS28 and UBC each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we show that a regulator of proliferatio... | |
medium_convergence_00748 | PRKN and SIAH1 share multiple interacting partners. One such partner is characterized by evidence stating: 'Here, we showed that Parkin directly interacts with this protein, but did not bind to pathogenic mutants of this protein.' Which protein is encoded by this gene? | Serine/threonine-protein kinase PINK1, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_00748","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and SIAH1 share multiple interacting partners. One such partner is characterized by evidence stating: 'Here, we showed that Parkin directly interacts wi... | |
medium_convergence_00749 | PLK1 and CCNA2 share common interaction partners. One such shared partner exhibits a specific binding mechanism where the interaction with PLK1 occurs through the polo-box domain of PLK1, and this partner is phosphorylated by PLK1 at threonine 37 (T37). Which protein is encoded by this shared interaction partner? | Cell division control protein 6 homolog | Medium | convergence | {"qa_id":"medium_convergence_00749","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PLK1 and CCNA2 share common interaction partners. One such shared partner exhibits a specific binding mechanism where the interaction with PLK1 occurs throug... | |
medium_convergence_00750 | Both KPNA1 and KPNB1 interact with a shared protein. Evidence for one such shared partner states: 'We found that [the protein encoded by PTPN2] co-immunoprecipitated with the nuclear import factor p97 from cell lysates and that purified recombinant p97 and [the protein encoded by PTPN2] interacted directly in vitro.' W... | Tyrosine-protein phosphatase non-receptor type 2 | Medium | convergence | {"qa_id":"medium_convergence_00750","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both KPNA1 and KPNB1 interact with a shared protein. Evidence for one such shared partner states: 'We found that [the protein encoded by PTPN2] co-immunoprec... | |
medium_convergence_00751 | EP300 and ESR1 share multiple binding partners. One of these shared interactors is described as the most estrogen-enriched ER interactor and is considered a potential clinical biomarker with no known function. Which disease is associated with this specific entity via a biomarker relationship? | hepatoblastoma | Medium | convergence | {"qa_id":"medium_convergence_00751","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and ESR1 share multiple binding partners. One of these shared interactors is described as the most estrogen-enriched ER interactor and is considered a ... |
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