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medium_convergence_05087 | LMNB1 and FZR1 share multiple interacting partners. One such shared partner is described in the following evidence: 'Here, we show that this protein interacts with two lamin A-binding proteins, proliferating cell nuclear antigen (PCNA), via a canonical PCNA-interacting protein (PIP) motif, and lamin B1.' Which protein ... | E3 ubiquitin-protein ligase HECW2 | Medium | convergence | {"qa_id":"medium_convergence_05087","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LMNB1 and FZR1 share multiple interacting partners. One such shared partner is described in the following evidence: 'Here, we show that this protein interact... | |
medium_convergence_05089 | WWP1 and CSNK2A1 both interact with a shared protein. Evidence indicates a direct interaction between this shared protein and disheveled segment polarity protein 2. Which protein is encoded by this shared entity? | Segment polarity protein dishevelled homolog DVL-2 | Medium | convergence | {"qa_id":"medium_convergence_05089","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WWP1 and CSNK2A1 both interact with a shared protein. Evidence indicates a direct interaction between this shared protein and disheveled segment polarity pro... | |
medium_convergence_05090 | OCLN and KRAS share a common interaction partner. Evidence indicates that occludin colocalizes with a nonreceptor tyrosine kinase at cell junctions and forms an immunoprecipitable complex with this kinase in vivo. Which gene is connected to this shared entity through a 'binds' relationship? | ZAP70 | Medium | convergence | {"qa_id":"medium_convergence_05090","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OCLN and KRAS share a common interaction partner. Evidence indicates that occludin colocalizes with a nonreceptor tyrosine kinase at cell junctions and forms... | |
medium_convergence_05091 | MYC and BRCA1 both interact with a shared protein. Evidence indicates that this shared protein functions as an adaptor molecule to recruit c-Myc to a complex containing itself, c-Myc, and BRCA1. Which gene encodes this shared protein? | N-myc-interactor | Medium | convergence | {"qa_id":"medium_convergence_05091","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and BRCA1 both interact with a shared protein. Evidence indicates that this shared protein functions as an adaptor molecule to recruit c-Myc to a complex... | |
medium_convergence_05092 | CENPA and CENPL each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified this protein.' Which disease is associated with that specific ent... | astrocytoma (excluding glioblastoma) | Medium | convergence | {"qa_id":"medium_convergence_05092","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPL each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosoma... | |
medium_convergence_05094 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Evidence for this shared target reports a log2 fold change of 2.480 and an adjusted p-value of 0.04657. Which protein is encoded by this gene? | Phorbol-12-myristate-13-acetate-induced protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05094","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Evidence for this shared target reports a log2 fold change of 2.480 and an adjusted... | |
medium_convergence_05095 | IMMP1L and PRKN share a common interacting partner. Evidence indicates that Parkinson's disease-causing mutations in PARK2 disrupt its molecular interaction with specific TOMM complex subunits, including the surface receptor, the shared partner, and the channel protein TOMM40. Which protein is encoded by this shared pa... | Mitochondrial import receptor subunit TOM70 | Medium | convergence | {"qa_id":"medium_convergence_05095","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IMMP1L and PRKN share a common interacting partner. Evidence indicates that Parkinson's disease-causing mutations in PARK2 disrupt its molecular interaction ... | |
medium_convergence_05096 | Vaccinia virus and Human alphaherpesvirus 1 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of -5.085 and an adjusted p-value of 0.005725. Which protein is encoded by this gene? | Interleukin-6 | Medium | convergence | {"qa_id":"medium_convergence_05096","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human alphaherpesvirus 1 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study ... | |
medium_convergence_05097 | Both Pegivirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for this gene, derived from peripheral blood mononuclear cells in study GSE131504, reports a log2 fold change of approximately 1.585 and an adjusted p-value of approximat... | Dual specificity protein phosphatase 2 | Medium | convergence | {"qa_id":"medium_convergence_05097","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Pegivirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for thi... | |
medium_convergence_05098 | DDB1 and TP53 share multiple interacting partners. One such partner is supported by evidence stating: 'Here, we demonstrate that this protein directly interacts with p53 via the p53 DNA-binding domain.' Which protein is encoded by this specific interacting partner? | Glutamate-rich WD repeat-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05098","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDB1 and TP53 share multiple interacting partners. One such partner is supported by evidence stating: 'Here, we demonstrate that this protein directly intera... | |
medium_convergence_05099 | Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.034 and an adjusted p-value of 0.01994. Which protein does this gene product interact with? | RHOB | Medium | convergence | {"qa_id":"medium_convergence_05099","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold ... | |
medium_convergence_05100 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of 1.411 and an adjusted p-value of 0.000909. Which protein is encoded by this gene? | Insulin receptor substrate 2 | Medium | convergence | {"qa_id":"medium_convergence_05100","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fo... | |
medium_convergence_05101 | MRE11A and RAD51 both interact with a shared protein partner. Evidence indicates that in assays using purified components, phosphorylation of RAD51 by c-Abl enhances complex formation between RAD51 and this shared partner, which cooperates with RAD51 in recombination and repair. Which gene interacts with this shared pa... | SUMO1 | Medium | convergence | {"qa_id":"medium_convergence_05101","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MRE11A and RAD51 both interact with a shared protein partner. Evidence indicates that in assays using purified components, phosphorylation of RAD51 by c-Abl ... | |
medium_convergence_05103 | AURKB and CDC20 share multiple binding partners. One specific shared partner mediates the interaction between Aurora-B and the APC/C complex; evidence indicates that Aurora-B is ubiquitinated and its protein levels increase upon treatment with proteasome inhibitors. Which disease is associated with this specific shared... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05103","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AURKB and CDC20 share multiple binding partners. One specific shared partner mediates the interaction between Aurora-B and the APC/C complex; evidence indica... | |
medium_convergence_05104 | EGFR and AMPH share multiple binding partners. One such shared partner is described by evidence stating that HB-EGF(44-86) exhibits high binding affinity to the EGF-receptor, similar to human-EGF. Which protein is encoded by this specific shared entity? | Proheparin-binding EGF-like growth factor | Medium | convergence | {"qa_id":"medium_convergence_05104","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and AMPH share multiple binding partners. One such shared partner is described by evidence stating that HB-EGF(44-86) exhibits high binding affinity to ... | |
medium_convergence_05105 | CREBBP and PARP1 share multiple interaction partners. One such shared partner has been shown to physically interact with the coactivator CREB-binding protein (CBP) both in vitro and in vivo. Which protein is encoded by this shared interaction partner? | Homeobox protein Hox-B7 | Medium | convergence | {"qa_id":"medium_convergence_05105","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and PARP1 share multiple interaction partners. One such shared partner has been shown to physically interact with the coactivator CREB-binding protein... | |
medium_convergence_05107 | PRKCA and PRKCZ each interact with more than one shared gene product. Evidence concerning one shared entity reports that PKCzeta was found to bind to a specific kinase under basal conditions using coimmunoprecipitation and the mammalian 2-hybrid assay. Which protein is encoded by that entity? | Mitogen-activated protein kinase 7 | Medium | convergence | {"qa_id":"medium_convergence_05107","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKCA and PRKCZ each interact with more than one shared gene product. Evidence concerning one shared entity reports that PKCzeta was found to bind to a speci... | |
medium_convergence_05108 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that for one such shared entity, the log2 fold change is approximately 1.01 and the adjusted p-value is approxi... | microtubule associated complex | Medium | convergence | {"qa_id":"medium_convergence_05108","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from ... | |
medium_convergence_05109 | DHX9 and LSM2 both interact with a specific gene product. Evidence indicates that this product interacts with RHA in vitro, and this interaction is impaired in mutant forms of the protein found in patients with spinal muscular atrophy. Which protein is encoded by this gene? | Survival motor neuron protein | Medium | convergence | {"qa_id":"medium_convergence_05109","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DHX9 and LSM2 both interact with a specific gene product. Evidence indicates that this product interacts with RHA in vitro, and this interaction is impaired ... | |
medium_convergence_05111 | PARP1 and BRD4 share common interacting partners. One such partner is described by the following mechanism: it binds PARP1 via a central PAR-binding WWE domain and, using its carboxy-terminal HECT domain, catalyzes the polyubiquitylation of PARP1, thereby triggering proteasomal degradation and preventing supra-physiolo... | basophil | Medium | convergence | {"qa_id":"medium_convergence_05111","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and BRD4 share common interacting partners. One such partner is described by the following mechanism: it binds PARP1 via a central PAR-binding WWE doma... | |
medium_convergence_05112 | ARAF and PRKN share common interaction partners. One such partner is supported by evidence showing that endogenous Parkin and this partner co-immunoprecipitated from HEK293 cells, SH-SY5Y cells, and adult mouse brain. Which cell type is this partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05112","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARAF and PRKN share common interaction partners. One such partner is supported by evidence showing that endogenous Parkin and this partner co-immunoprecipita... | |
medium_convergence_05113 | The biological processes 'negative regulation of glycine import across plasma membrane' and 'negative regulation of glycine secretion, neurotransmission' both share a common parent process. Evidence regarding this shared process states: 'Any process that stops, prevents or reduces the frequency, rate or extent of glyci... | amino acid transport | Medium | convergence | {"qa_id":"medium_convergence_05113","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'negative regulation of glycine import across plasma membrane' and 'negative regulation of glycine secretion, neurotransmission' bot... | |
medium_convergence_05114 | KRT40 and KRT18 both interact with a common partner protein. Evidence regarding this partner states: 'The explanation does not appear to reside in an inability of K18 to form 10-nm filaments with K5, which it does in vitro and in vivo.' Which biological process is this partner protein involved in? | epidermis development | Medium | convergence | {"qa_id":"medium_convergence_05114","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRT40 and KRT18 both interact with a common partner protein. Evidence regarding this partner states: 'The explanation does not appear to reside in an inabili... | |
medium_convergence_05115 | Efalizumab and Interferon alfa-2b share interactions with multiple drugs. One such shared drug was studied in a trial enrolling 70 non-Hodgkin's lymphoma (NHL) patients, who received either the drug alone (10 mg/day) or in combination with Interferon alfa-2b (5 million units/m2 subcutaneously three times a week). Which... | lymphosarcoma | Medium | convergence | {"qa_id":"medium_convergence_05115","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Efalizumab and Interferon alfa-2b share interactions with multiple drugs. One such shared drug was studied in a trial enrolling 70 non-Hodgkin's lymphoma (NH... | |
medium_convergence_05116 | KAT2A and BAZ1B both interact with a shared protein partner. Evidence regarding one such partner states: 'We show here that the WICH complex (WSTF-SNF2h) interacts with several nuclear proteins as follows: Sf3b155/SAP155, RNA helicase II/Gualpha, [a Myb-binding protein], CSB, the proto-oncogene Dek, and nuclear myosin ... | small cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05116","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT2A and BAZ1B both interact with a shared protein partner. Evidence regarding one such partner states: 'We show here that the WICH complex (WSTF-SNF2h) int... | |
medium_convergence_05117 | ELK1 and ARRB2 share common binding partners. One such shared partner is a kinase that, when acetylated, exhibits reduced enzymatic activity toward the transcription factor ELK1, which is a well-known substrate of this kinase. Which protein is encoded by this shared kinase? | Mitogen-activated protein kinase 3 | Medium | convergence | {"qa_id":"medium_convergence_05117","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ELK1 and ARRB2 share common binding partners. One such shared partner is a kinase that, when acetylated, exhibits reduced enzymatic activity toward the trans... | |
medium_convergence_05118 | COPS4 and CUL4A each interact with more than one shared protein. Evidence concerning one shared entity reports that UV-DDB consists of this entity and another partner, and it is a component of the cullin 4A-based ubiquitin ligase. Which protein is connected to that entity through the 'encodes' relation? | DNA damage-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05118","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS4 and CUL4A each interact with more than one shared protein. Evidence concerning one shared entity reports that UV-DDB consists of this entity and anothe... | |
medium_convergence_05119 | CHEK1 and ESCO2 share common interacting partners. One such partner is identified in a study reporting the identification of the heterohexamic minichromosome maintenance (MCM) complex that interacts with Chk1 by mass spectrometry. Which disease is associated with this specific interacting entity? | cervical cancer | Medium | convergence | {"qa_id":"medium_convergence_05119","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and ESCO2 share common interacting partners. One such partner is identified in a study reporting the identification of the heterohexamic minichromosome... | |
medium_convergence_05120 | MYC and PLK1 share common interacting partners. One such shared partner has an interaction with PLK1 that was confirmed using a β-galactosidase and growth test in selective media, in vitro glutathione S-transferase pull-down, and in vivo immunoprecipitation assays. Which protein product is encoded by this specific shar... | E3 ubiquitin-protein ligase RING2 | Medium | convergence | {"qa_id":"medium_convergence_05120","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and PLK1 share common interacting partners. One such shared partner has an interaction with PLK1 that was confirmed using a β-galactosidase and growth te... | |
medium_convergence_05122 | PARP1 and EP300 share multiple interacting partners. One such shared partner is reported to physically interact with both PARP-1 and NFATc2. Which cell type is this shared partner enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_05122","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and EP300 share multiple interacting partners. One such shared partner is reported to physically interact with both PARP-1 and NFATc2. Which cell type ... | |
medium_convergence_05124 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental evidence for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately 1.277 and an adjusted p-value of 1.378e-06. Which protein does this gene product bind to? | RHOQ | Medium | convergence | {"qa_id":"medium_convergence_05124","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental evidence for this gene in foreskin fibroblast cell lines reports a log... | |
medium_convergence_05125 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene in monocytic leukemia cell lines (study GSE114966). Evidence for this shared target reports a log2 fold change of 3.275 and an adjusted p-value of 0.007785. Which protein is encoded by this gene? | Histone H2A type 1-H | Medium | convergence | {"qa_id":"medium_convergence_05125","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene in monocytic leukemia cell lines (study GSE114966). Evidence for this sh... | |
medium_convergence_05128 | Both Influenza A virus and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of -2.453 and an adjusted p-value of 0.001072. In which cell type is this gene enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05128","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of -... | |
medium_convergence_05129 | Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of -1.266 and an adjusted p-value of 0.004108. Which protein is encoded by this gene? | Serine/arginine-rich splicing factor 8 | Medium | convergence | {"qa_id":"medium_convergence_05129","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_05130 | Both Measles morbillivirus and Rhinovirus A are reported to downregulate a specific gene. Evidence for this shared target indicates a log2 fold change of -1.275 and an adjusted p-value of 0.0003926. Which disease is associated with this gene? | aortic valve stenosis | Medium | convergence | {"qa_id":"medium_convergence_05130","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rhinovirus A are reported to downregulate a specific gene. Evidence for this shared target indicates a log2 fold change of -1.... | |
medium_convergence_05131 | Rhinovirus A and Zika virus both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.66 and an adjusted p-value of 0.004459. Which cellular component is this gene located in? | cytosol | Medium | convergence | {"qa_id":"medium_convergence_05131","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold cha... | |
medium_convergence_05132 | CCT2 and IGBP1 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Using the yeast two-hybrid system, we have found that alpha 4, a previously identified phosphoprotein, associates constitutively with the catalytic subunits of [Protein X], PP6, and both isoforms of PP2A.' ... | Serine/threonine-protein phosphatase 4 catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_05132","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCT2 and IGBP1 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Using the yeast two-hybrid system, we have ... | |
medium_convergence_05133 | Both Human immunodeficiency virus 1 and Dengue virus are reported to upregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) indicates a log2 fold change of approximately 1.99 and an adjusted p-value of 0.00025. What is the protein encoded by this gene? | Krueppel-like factor 4 | Medium | convergence | {"qa_id":"medium_convergence_05133","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to upregulate a specific gene. Experimental data for this gene in macrophages (from study G... | |
medium_convergence_05134 | CSNK1E and CTNNB1 share a common binding partner. Evidence indicates that this shared entity, also known as a specific F-box protein, functions as part of the SCF complex with Skp1 and Cullin1, specifically interacting with phosphorylated IkappaB and beta-catenin to target them for proteasome-dependent degradation in v... | neurodevelopmental, jaw, eye, and digital syndrome | Medium | convergence | {"qa_id":"medium_convergence_05134","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1E and CTNNB1 share a common binding partner. Evidence indicates that this shared entity, also known as a specific F-box protein, functions as part of th... | |
medium_convergence_05135 | M6PR and RAB9A share binding partners. One shared partner is described as a 40-kD protein (p40) that binds Rab9-GTP with roughly fourfold preference to Rab9-GDP. Which cellular component is this specific protein located in? | endosome | Medium | convergence | {"qa_id":"medium_convergence_05135","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"M6PR and RAB9A share binding partners. One shared partner is described as a 40-kD protein (p40) that binds Rab9-GTP with roughly fourfold preference to Rab9-... | |
medium_convergence_05136 | CTBP1 and CTNNB1 share a common interaction partner. Evidence indicates that this shared partner interacts directly with CTBP1 and other Fanconi anemia (FA) core complex proteins. Which cell type is this shared partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05136","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and CTNNB1 share a common interaction partner. Evidence indicates that this shared partner interacts directly with CTBP1 and other Fanconi anemia (FA) ... | |
medium_convergence_05137 | Human respirovirus 3 and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of 1.446 and an adjusted p-value of 0.04936. Which disease is associated with this gene through genomic alterations? | breast ductal adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_05137","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line ... | |
medium_convergence_05138 | POLR2E and POLR2L both interact with a specific protein. Evidence indicates that the interaction between this protein and RNA Polymerase II is direct and mediated by the RPB1 subunit of RNA Polymerase II. Which protein product is encoded by this interacting protein? | ATP-dependent DNA helicase Q5 | Medium | convergence | {"qa_id":"medium_convergence_05138","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLR2E and POLR2L both interact with a specific protein. Evidence indicates that the interaction between this protein and RNA Polymerase II is direct and med... | |
medium_convergence_05139 | Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus both downregulate a specific gene. Evidence for this shared target in gamma delta T-lymphocytes (from study GSE13906) reports a log2 fold change of -2.069 and an adjusted p-value of 0.03338. Which protein is encoded by this gene? | Endothelial lipase | Medium | convergence | {"qa_id":"medium_convergence_05139","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus both downregulate a specific gene. Evidence for this shared target in gamm... | |
medium_convergence_05140 | AKT1 and FGFR1 share a common interacting partner. Evidence regarding this partner states: 'We identified a novel protein, which binds to PKB, using a yeast two-hybrid screening system.' Which protein is encoded by this shared interacting partner? | Girdin | Medium | convergence | {"qa_id":"medium_convergence_05140","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and FGFR1 share a common interacting partner. Evidence regarding this partner states: 'We identified a novel protein, which binds to PKB, using a yeast ... | |
medium_convergence_05141 | The pontine raphe nucleus and the nucleus of the superior olivary complex are both classified as a specific type of anatomical structure. Evidence indicates that the pontine raphe nucleus is one of the raphe nuclei and is located in the pontine tegmentum. Based on this classification, which larger anatomical region is ... | brainstem | Medium | convergence | {"qa_id":"medium_convergence_05141","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The pontine raphe nucleus and the nucleus of the superior olivary complex are both classified as a specific type of anatomical structure. Evidence indicates ... | |
medium_convergence_05142 | CHUK and RIGI each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In this study, we identified REUL, a RING-finger protein, as a specific RIG-I-interacting protein.' Which protein is connected to that entity through the 'encodes' relationship? | E3 ubiquitin-protein ligase RNF135 | Medium | convergence | {"qa_id":"medium_convergence_05142","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and RIGI each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In this study, we identified REUL, a RING-fing... | |
medium_convergence_05143 | Both 'negative regulation of eosinophil degranulation' and 'negative regulation of neutrophil degranulation' are subtypes of a shared biological process. Evidence regarding this shared process states: 'Any process that stops, prevents, or reduces the rate of eosinophil degranulation.' Which biological process is negati... | immune response | Medium | convergence | {"qa_id":"medium_convergence_05143","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'negative regulation of eosinophil degranulation' and 'negative regulation of neutrophil degranulation' are subtypes of a shared biological process. Evi... | |
medium_convergence_05144 | RAB4A and YWHAE share a common interaction partner. Evidence regarding this shared partner states: 'This domain mediates the direct interaction with the GTP-bound form of Rab4, a small GTPase that has been implicated in recycling from early endosomes to the cell surface.' Which protein is encoded by this shared interac... | Rab GTPase-binding effector protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05144","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAB4A and YWHAE share a common interaction partner. Evidence regarding this shared partner states: 'This domain mediates the direct interaction with the GTP-... | |
medium_convergence_05145 | ERBB2 and BTC both interact with a shared protein partner. Evidence regarding this partner states: 'We show that 8 of 10 possible homo-and heterodimeric complexes of ErbB proteins can be hierarchically induced by ligand binding.' Which protein is encoded by this shared partner? | Receptor tyrosine-protein kinase erbB-4 | Medium | convergence | {"qa_id":"medium_convergence_05145","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and BTC both interact with a shared protein partner. Evidence regarding this partner states: 'We show that 8 of 10 possible homo-and heterodimeric comp... | |
medium_convergence_05146 | FANCD2 and MSH2 both interact with a shared protein. Experimental evidence indicates that this shared protein colocalizes and co-immunoprecipitates with FANCD2 following treatment with DNA crosslinkers or agents inducing replication arrest. Which protein is encoded by the gene corresponding to this shared entity? | RecQ-like DNA helicase BLM | Medium | convergence | {"qa_id":"medium_convergence_05146","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCD2 and MSH2 both interact with a shared protein. Experimental evidence indicates that this shared protein colocalizes and co-immunoprecipitates with FANC... | |
medium_convergence_05147 | FKBP5 and HSP90AA1 both interact with a specific gene product. Evidence regarding this shared interaction partner states: 'We also identify a PXLE motif in HSP90 itself that can mediate binding to the shared partner but find that this interaction is maintained with the D4E/C127S haplotype of the shared partner.' Which ... | Egl nine homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_05147","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FKBP5 and HSP90AA1 both interact with a specific gene product. Evidence regarding this shared interaction partner states: 'We also identify a PXLE motif in H... | |
medium_convergence_05148 | PDGFB and XBP1 are both involved in more than one shared biological process. Evidence indicates that spliced XBP1 increases smooth muscle cell (SMC) migration via PI3K/Akt activation. Which biological process, connected to this entity through the relation 'positively regulates', is supported by this evidence? | vascular associated smooth muscle cell migration | Medium | convergence | {"qa_id":"medium_convergence_05148","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDGFB and XBP1 are both involved in more than one shared biological process. Evidence indicates that spliced XBP1 increases smooth muscle cell (SMC) migratio... | |
medium_convergence_05149 | ATG12 and ATG5 both interact with a specific protein. Evidence indicates that Atg16L1 directly binds this protein, which is identified as a WD-repeat PtdIns(3)P effector (a WIPI protein). Which protein is encoded by the gene corresponding to this interacting partner? | WD repeat domain phosphoinositide-interacting protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05149","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG12 and ATG5 both interact with a specific protein. Evidence indicates that Atg16L1 directly binds this protein, which is identified as a WD-repeat PtdIns(... | |
medium_convergence_05150 | DLG2 and DLG4 both interact with a shared protein entity. Evidence regarding this entity states: 'We have isolated here a novel protein family consisting of at least four members which specifically interact with PSD-95/SAP90 and its related proteins through the guanylate kinase domain, and named these proteins SAPAPs (... | Disks large-associated protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05150","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG2 and DLG4 both interact with a shared protein entity. Evidence regarding this entity states: 'We have isolated here a novel protein family consisting of ... | |
medium_convergence_05151 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE11238) indicates that this gene has a log2 fold change of -2.314 and an adjusted p-value of 0.005765. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05151","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE11238) indicates... | |
medium_convergence_05152 | Carmustine and Bleomycin both interact with a specific shared drug. Evidence indicates that a combination regimen including this shared drug, along with mitomycin C and carmustine, is effective in pretreated patients. Which disease is this shared drug indicated for? | liver cancer | Medium | convergence | {"qa_id":"medium_convergence_05152","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Carmustine and Bleomycin both interact with a specific shared drug. Evidence indicates that a combination regimen including this shared drug, along with mito... | |
medium_convergence_05154 | MDM2 and TP53 share a common interacting partner. Evidence for this partner states: 'We found that hPer2 binds the C-terminal half of human p53 (hp53) and forms a stable trimeric complex with hp53's negative regulator, Mdm2.' Which cellular component is this partner located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_05154","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and TP53 share a common interacting partner. Evidence for this partner states: 'We found that hPer2 binds the C-terminal half of human p53 (hp53) and fo... | |
medium_convergence_05155 | Both Human immunodeficiency virus 1 and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene, derived from natural killer cells, reports a log2 fold change of approximately 1.19 and an adjusted p-value of 0.034. Which cellular component is this gene located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_05155","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene, derived from ... | |
medium_convergence_05156 | MAPK3 and BRAF both interact with a shared protein. Biochemical evidence indicates that residues Raf-Arg59 and Raf-Arg67 from the Raf RBD interact with Ras-Glu37 in the Ras effector region. Which cell type is this shared protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05156","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK3 and BRAF both interact with a shared protein. Biochemical evidence indicates that residues Raf-Arg59 and Raf-Arg67 from the Raf RBD interact with Ras-G... | |
medium_convergence_05157 | ADRM1 and PSMA5 both interact with a common protein partner. Evidence regarding this shared partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein is encoded by this shared p... | Proteasome subunit alpha type-7 | Medium | convergence | {"qa_id":"medium_convergence_05157","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRM1 and PSMA5 both interact with a common protein partner. Evidence regarding this shared partner states: 'In the present study, we demonstrate that the 20... | |
medium_convergence_05158 | PRMT5 and CREBBP share multiple interacting partners. One such shared partner is described in a study using mass spectrometry to identify nuclear and cytoplasmic CBP-interacting proteins, which identified a protein encoded by the gene CCAR2 as a stoichiometric CBP-interacting protein that negatively regulates CBP-depen... | Cell cycle and apoptosis regulator protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05158","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRMT5 and CREBBP share multiple interacting partners. One such shared partner is described in a study using mass spectrometry to identify nuclear and cytopla... | |
medium_convergence_05159 | Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene indicates a log2 fold change of -1.103 and an adjusted p-value of 0.003948. Which protein is encoded by this gene? | Acylphosphatase-1 | Medium | convergence | {"qa_id":"medium_convergence_05159","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene indicates a log2 fold... | |
medium_convergence_05160 | PARP1 and SIRT1 share common interaction partners. One such partner is characterized by evidence stating: 'We found that DNA damage provokes interaction of SIRT1 and [this entity], which phosphorylates SIRT1 at Serine 682 upon lethal damage.' Which disease is associated with this entity via genomic alterations? | childhood pilocytic astrocytoma | Medium | convergence | {"qa_id":"medium_convergence_05160","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and SIRT1 share common interaction partners. One such partner is characterized by evidence stating: 'We found that DNA damage provokes interaction of S... | |
medium_convergence_05161 | GNB5 and GNB1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The gamma 10 is modified by a geranylgeranyl group and is capable of interacting with beta 1 and beta 2 but not with beta 3.' Which protein is encoded by the gene corresponding to that shared... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | Medium | convergence | {"qa_id":"medium_convergence_05161","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNB5 and GNB1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The gamma 10 is modified by ... | |
medium_convergence_05162 | EPS15L1 and CBL each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we demonstrate that h[ENTITY] associates directly with c-Cbl, a known down-regulator of RTK signaling.' Which disease is connected to that entity through genomic alterations? | Metaphyseal chondrodysplasia, McKusick type | Medium | convergence | {"qa_id":"medium_convergence_05162","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPS15L1 and CBL each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we demonstrate that h[ENTITY] associat... | |
medium_convergence_05163 | Triamcinolone and Hydrocortisone share a common interacting drug. Evidence regarding this shared entity notes that similar increases in acetylcholine (ACh) are observed with other glucocorticoids (plus Physostigmine), specifically prednisolone (6-9 microM), corticosterone (2 microM), and the shared entity (2 microM). F... | myasthenia gravis | Medium | convergence | {"qa_id":"medium_convergence_05163","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Triamcinolone and Hydrocortisone share a common interacting drug. Evidence regarding this shared entity notes that similar increases in acetylcholine (ACh) a... | |
medium_convergence_05165 | Both Human alphaherpesvirus 3 and Measles morbillivirus are known to downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of -1.168 and an adjusted p-value of 2.019e-05. Which disease is associated with this gene through genomic altera... | Miller-Dieker lissencephaly syndrome | Medium | convergence | {"qa_id":"medium_convergence_05165","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Measles morbillivirus are known to downregulate a specific shared gene. Experimental data for this gene in a melanoma cell ... | |
medium_convergence_05166 | NUB1 and PSMA3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'A yeast two-hybrid screen identified NEDD8 ultimate buster-1L (NUB1L) as a non-covalent binding partner of a ubiquitin-like modifier, and this interaction was confirmed by coimmunoprecipitat... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_05166","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUB1 and PSMA3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'A yeast two-hybrid screen i... | |
medium_convergence_05167 | FUS and RBMX both interact with a shared protein. Evidence indicates that this shared protein is involved in the specific binding of Htra2-beta1, an SR-like splicing factor known to stimulate the inclusion of exon 7 in SMN2 pre-mRNA through direct interaction with an AG-rich exonic splicing enhancer. Which protein is e... | Transformer-2 protein homolog beta | Medium | convergence | {"qa_id":"medium_convergence_05167","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FUS and RBMX both interact with a shared protein. Evidence indicates that this shared protein is involved in the specific binding of Htra2-beta1, an SR-like ... | |
medium_convergence_05168 | BRD4 and KMT2A both interact with a shared protein entity. Evidence regarding this entity states: 'Here we show MLL interacts directly with the polymerase associated factor complex (PAFc) through sequences flanking the CxxC domain.' Which protein is connected to this entity through the 'encodes' relationship? | RNA polymerase II-associated factor 1 homolog | Medium | convergence | {"qa_id":"medium_convergence_05168","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and KMT2A both interact with a shared protein entity. Evidence regarding this entity states: 'Here we show MLL interacts directly with the polymerase as... | |
medium_convergence_05169 | CNIH3 and GOLGA2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'The GTP form of this protein regulates ER to Golgi transport by interaction with the vesicle tethering factor p115 and the cis-Golgi matrix protein GM130, also part of a complex with GRASP65 important for t... | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_05169","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNIH3 and GOLGA2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'The GTP form of this protein regulates ER t... | |
medium_convergence_05170 | TRIOBP and HSP90AA1 both interact with a common protein. Evidence regarding this shared partner describes the localization and functional consequences of its direct interaction with a potassium channel protein in the heart. Which protein is encoded by the gene corresponding to this shared partner? | Voltage-gated inwardly rectifying potassium channel KCNH2 | Medium | convergence | {"qa_id":"medium_convergence_05170","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIOBP and HSP90AA1 both interact with a common protein. Evidence regarding this shared partner describes the localization and functional consequences of its... | |
medium_convergence_05171 | Osteocytes and non-terminally differentiated osteoblasts are both components of a specific anatomical structure. Evidence indicates that this structure is a type of mineralized tissue that always includes both osteocytes and non-terminally differentiated osteoblasts. What is the broader tissue category to which this sp... | mineralized bone tissue | Medium | convergence | {"qa_id":"medium_convergence_05171","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Osteocytes and non-terminally differentiated osteoblasts are both components of a specific anatomical structure. Evidence indicates that this structure is a ... | |
medium_convergence_05172 | UBE2D2 and UBE2L3 both interact with a shared protein. Evidence indicates that this shared protein is an E3 ligase that can be loaded with ubiquitin from the E2 enzyme UBE2D2. Which protein is encoded by the gene corresponding to this shared entity? | E3 ubiquitin-protein ligase RNF14 | Medium | convergence | {"qa_id":"medium_convergence_05172","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBE2D2 and UBE2L3 both interact with a shared protein. Evidence indicates that this shared protein is an E3 ligase that can be loaded with ubiquitin from the... | |
medium_convergence_05173 | CENPH and CENPT each interact with more than one shared partner. Evidence concerning one shared entity reports: 'The CENP-T·CENP-W complex is a recently identified inner centromere component that plays crucial roles in the formation of a functional kinetochore involved in cell division during mitosis.' Which molecular ... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05173","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPH and CENPT each interact with more than one shared partner. Evidence concerning one shared entity reports: 'The CENP-T·CENP-W complex is a recently iden... | |
medium_convergence_05174 | CDKN1A and CDKN1B both interact with a shared gene product. Experimental evidence indicates that immunoprecipitations from HTLV-1 infected cells revealed p21/waf1 in a stable complex with this shared gene product and cdk4. Which disease is associated with this shared gene product through genomic alterations? | ductal breast carcinoma in situ | Medium | convergence | {"qa_id":"medium_convergence_05174","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1A and CDKN1B both interact with a shared gene product. Experimental evidence indicates that immunoprecipitations from HTLV-1 infected cells revealed p21... | |
medium_convergence_05175 | ESR1 and BCL11B both interact with a shared protein. Evidence regarding this shared protein states: 'The enhancement of the human estrogen receptor alpha (hER alpha, NR3A1) activity by the orphan nuclear receptor [shared protein] is found to depend on the establishment of a tight hER alpha-[shared protein] complex.' Wh... | COUP transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_05175","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and BCL11B both interact with a shared protein. Evidence regarding this shared protein states: 'The enhancement of the human estrogen receptor alpha (hE... | |
medium_convergence_05176 | UBE2D2 and UBE2E2 both interact with a shared protein. Evidence indicates that this shared protein is an E3 ligase that can be loaded with ubiquitin from the E2 enzyme UBE2D2. Which cell type is this shared protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05176","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBE2D2 and UBE2E2 both interact with a shared protein. Evidence indicates that this shared protein is an E3 ligase that can be loaded with ubiquitin from the... | |
medium_convergence_05177 | CSNK2A1 and DAB2 both interact with a shared protein. Evidence regarding this shared protein states: 'Using a small-pool cDNA screening strategy, we identify that the N-terminal domain of Dab2 interacts with Dishevelled-3 (Dvl-3), a signaling mediator of the Wnt pathway.' Which protein is encoded by this shared entity? | Segment polarity protein dishevelled homolog DVL-3 | Medium | convergence | {"qa_id":"medium_convergence_05177","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and DAB2 both interact with a shared protein. Evidence regarding this shared protein states: 'Using a small-pool cDNA screening strategy, we identify... | |
medium_convergence_05178 | CHMP4B and CHMP7 both interact with a specific protein. Experimental evidence indicates that in a yeast two-hybrid assay, HD-PTP showed positive interactions with this protein (also known as Shax1), endophilin A1, and ALG-2, but not with RabGAPLP or CIN85. Which protein is encoded by the gene corresponding to this inte... | Programmed cell death 6-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_05178","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and CHMP7 both interact with a specific protein. Experimental evidence indicates that in a yeast two-hybrid assay, HD-PTP showed positive interactions... | |
medium_convergence_05179 | Both Human alphaherpesvirus 3 and Dengue virus are known to upregulate the expression of specific host genes. One such shared target gene exhibits a log2 fold change of approximately 1.405 and an adjusted p-value of 7.635e-05 in melanoma cell lines (study GSE136586). What molecular function is enabled by this specific ... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05179","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Dengue virus are known to upregulate the expression of specific host genes. One such shared target gene exhibits a log2 fol... | |
medium_convergence_05180 | Alveolar type 1 fibroblast cells and alveolar adventitial fibroblasts share a common parent cell type. Evidence indicates that a specific instance of this shared cell type is part of the alveolus and contains lipid droplets. Which anatomical structure is this shared cell type a part of? | respiratory system | Medium | convergence | {"qa_id":"medium_convergence_05180","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Alveolar type 1 fibroblast cells and alveolar adventitial fibroblasts share a common parent cell type. Evidence indicates that a specific instance of this sh... | |
medium_convergence_05181 | XRCC6 and AR both interact with a shared protein. Evidence indicates that a ligand-dependent protein-protein interaction was identified between a specific protein and this shared entity. Which protein is encoded by this shared entity? | Zinc finger and BTB domain-containing protein 7A | Medium | convergence | {"qa_id":"medium_convergence_05181","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and AR both interact with a shared protein. Evidence indicates that a ligand-dependent protein-protein interaction was identified between a specific pr... | |
medium_convergence_05182 | Rhinovirus A and Zika virus both upregulate a specific gene in cytotoxic T-lymphocytes. Evidence for this shared target reports a log2 fold change of approximately 1.71 and an adjusted p-value of 0.0494. Which protein is encoded by this gene? | Putative histone H2B type 2-D | Medium | convergence | {"qa_id":"medium_convergence_05182","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene in cytotoxic T-lymphocytes. Evidence for this shared target reports a log2 fold change of approxi... | |
medium_convergence_05183 | ERBB2 and RPA1 share a common interaction partner. Evidence indicates that this shared entity is nuclear, physically associates with β-actin and RNA Polymerase I, and coincides with active RNA Polymerase I transcription sites in nucleoli. Which cell type is enriched for this entity? | mucosal-associated invariant T cell | Medium | convergence | {"qa_id":"medium_convergence_05183","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and RPA1 share a common interaction partner. Evidence indicates that this shared entity is nuclear, physically associates with β-actin and RNA Polymera... | |
medium_convergence_05184 | GABRA1 and GABRB3 are both involved in multiple shared biological processes. One of these shared processes is characterized by evidence that the associated entities support spontaneous and action potential-driven postsynaptic GABAergic currents. What is the parent biological process (via an 'is a' relationship) of this... | chemical synaptic transmission | Medium | convergence | {"qa_id":"medium_convergence_05184","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GABRA1 and GABRB3 are both involved in multiple shared biological processes. One of these shared processes is characterized by evidence that the associated e... | |
medium_convergence_05185 | Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Evidence for this shared target reports a log2 fold change of -1.155 and an adjusted p-value of 0.01869. Which protein is encoded by this gene? | Threonine synthase-like 1 | Medium | convergence | {"qa_id":"medium_convergence_05185","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Evidence for this shared target reports a log2 fold c... | |
medium_convergence_05186 | E2F1 and ESR1 share multiple interacting partners. One such shared partner is specifically reported to interact with the E2F-1 transactivation domain. Which protein is encoded by this shared partner? | Transformation/transcription domain-associated protein | Medium | convergence | {"qa_id":"medium_convergence_05186","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F1 and ESR1 share multiple interacting partners. One such shared partner is specifically reported to interact with the E2F-1 transactivation domain. Which ... | |
medium_convergence_05187 | ATP1A1 and ATP1A2 both interact with a specific beta subunit of the sodium/potassium-transporting ATPase. Experimental evidence indicates that RNF183 interacts with both the alpha-1 and beta-1 subunits, but ubiquitinates only the beta-1 subunit. Which protein product is encoded by the gene corresponding to this beta-1 ... | Sodium/potassium-transporting ATPase subunit beta-1 | Medium | convergence | {"qa_id":"medium_convergence_05187","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATP1A1 and ATP1A2 both interact with a specific beta subunit of the sodium/potassium-transporting ATPase. Experimental evidence indicates that RNF183 interac... | |
medium_convergence_05188 | EHMT2 and PARP1 share common interaction partners. One such shared partner is described by the following evidence: 'Here we show that this protein binds histone lysine methyltransferase G9a, and both are co-localized in the nucleus in a cell-cycle-dependent manner.' Which protein is encoded by this shared entity? | E3 ubiquitin-protein ligase UHRF1 | Medium | convergence | {"qa_id":"medium_convergence_05188","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and PARP1 share common interaction partners. One such shared partner is described by the following evidence: 'Here we show that this protein binds hist... | |
medium_convergence_05189 | CSNK2B and MAPK1 both interact with a shared protein. Experimental evidence indicates that ERK1 and ERK2 were detected in immunoprecipitates of RSK3 (and to a lesser extent, a related kinase), but were absent in RSK1 immunoprecipitates. Which cell type is enriched for this shared protein? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05189","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and MAPK1 both interact with a shared protein. Experimental evidence indicates that ERK1 and ERK2 were detected in immunoprecipitates of RSK3 (and to ... | |
medium_convergence_05191 | UHRF2 and PARP1 both interact with a common protein. Evidence indicates that this shared protein physically interacts with UHRF2 in a DNA damage-dependent manner, specifically mediated by UHRF2's TTD domain. Which protein is encoded by this shared entity? | Serine/threonine-protein kinase ATR | Medium | convergence | {"qa_id":"medium_convergence_05191","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UHRF2 and PARP1 both interact with a common protein. Evidence indicates that this shared protein physically interacts with UHRF2 in a DNA damage-dependent ma... | |
medium_convergence_05192 | TGFB2 and TGFB3 are both involved in more than one shared biological process. Evidence regarding one of these shared processes indicates that TGF-beta 2 was detected starting from the bud stage of the salivary gland, with expression observed in ductal cells that increased along gland differentiation. Which biological p... | gland morphogenesis | Medium | convergence | {"qa_id":"medium_convergence_05192","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TGFB2 and TGFB3 are both involved in more than one shared biological process. Evidence regarding one of these shared processes indicates that TGF-beta 2 was ... | |
medium_convergence_05194 | NCF2 and NCF4 share common binding partners. One such shared partner is Rac1. Evidence indicates that this shared partner can bind to p67(phox) amino acid residues 170-199, and the N terminus (amino acids 1-192) of p67(phox) can be used as a specific inhibitor of Rac signaling. Which protein is connected to this shared... | Ras-related C3 botulinum toxin substrate 2 | Medium | convergence | {"qa_id":"medium_convergence_05194","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCF2 and NCF4 share common binding partners. One such shared partner is Rac1. Evidence indicates that this shared partner can bind to p67(phox) amino acid re... | |
medium_convergence_05195 | SIN3B and RB1 share multiple interacting partners. One such partner is Retinoblastoma-binding protein 2 (Rbp2), which was originally identified as a retinoblastoma protein (RB) pocket domain-binding protein. Which cell type is enriched for the gene encoding this specific shared partner? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05195","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3B and RB1 share multiple interacting partners. One such partner is Retinoblastoma-binding protein 2 (Rbp2), which was originally identified as a retinobl... | |
medium_convergence_05196 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data for this gene in a study (GSE135619) reports a log2 fold change of approximately -1.602 and an adjusted p-value of 0.04951. Which cell type is this gene enriched i... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_05196","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data ... | |
medium_convergence_05197 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of -1.248 and an adjusted p-value of 0.03817. Which protein is encoded by this gene? | SH3 domain-binding protein 5 | Medium | convergence | {"qa_id":"medium_convergence_05197","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) ind... | |
medium_convergence_05198 | Both Influenza A virus and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE106279) reports a log2 fold change of -2.958 and an adjusted p-value of 0.002389. Which protein is encoded by this gene? | Transforming growth factor-beta-induced protein ig-h3 | Medium | convergence | {"qa_id":"medium_convergence_05198","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in a non-small cell lung a... | |
medium_convergence_05200 | BIRC2 and BIRC6 both interact with a shared protein. Evidence regarding this shared entity states: 'Similarly to XIAP, in vitro binding experiments indicated that c-IAP-1 and c-IAP-2 bound specifically to the terminal effector cell death proteases, caspases-3 and -7, but not to the proximal protease caspase-8, caspases... | medulloblastoma | Medium | convergence | {"qa_id":"medium_convergence_05200","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and BIRC6 both interact with a shared protein. Evidence regarding this shared entity states: 'Similarly to XIAP, in vitro binding experiments indicated... |
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