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medium_convergence_05201 | CENPC and CENPT each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'The CENP-T·CENP-W complex is a recently identified inner centromere component that plays crucial roles in the formation of a functional kinetochore involved in cell division during mitosis.' Which molec... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05201","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPC and CENPT each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'The CENP-T·CENP-W complex is a recently... | |
medium_convergence_05203 | NEDD4L and NEDD4 both interact with a shared gene product. Evidence regarding this shared entity states: 'We demonstrate that KIAA0439 WW domains bind all three ENaC subunits.' Which gene interacts with this shared entity? | USP2 | Medium | convergence | {"qa_id":"medium_convergence_05203","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and NEDD4 both interact with a shared gene product. Evidence regarding this shared entity states: 'We demonstrate that KIAA0439 WW domains bind all th... | |
medium_convergence_05206 | EME1 and CENPS both interact with a shared protein. Biochemical evidence indicates that MHF1 and MHF2 form a heterodimer that binds DNA and enhances the DNA branch migration activity of this shared protein. Which protein is encoded by the gene corresponding to this shared entity? | Fanconi anemia core complex-associated protein 24 | Medium | convergence | {"qa_id":"medium_convergence_05206","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EME1 and CENPS both interact with a shared protein. Biochemical evidence indicates that MHF1 and MHF2 form a heterodimer that binds DNA and enhances the DNA ... | |
medium_convergence_05207 | Lenalidomide and Prednisone both interact with a specific third drug. Clinical evidence highlights that combining this third drug with either Lenalidomide or Pomalidomide results in excessive and unpredictable toxicity. Which disease is this third drug indicated for? | colorectal cancer | Medium | convergence | {"qa_id":"medium_convergence_05207","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Lenalidomide and Prednisone both interact with a specific third drug. Clinical evidence highlights that combining this third drug with either Lenalidomide or... | |
medium_convergence_05208 | HSP90AA1 and STING1 (encoded by TMEM173) share common interacting partners. One such shared partner is reported to be ubiquitinated by CHIP when CHIP is bound to HSP90. Which protein encodes this specific shared interacting partner? | Ubiquitin carboxyl-terminal hydrolase 35 | Medium | convergence | {"qa_id":"medium_convergence_05208","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and STING1 (encoded by TMEM173) share common interacting partners. One such shared partner is reported to be ubiquitinated by CHIP when CHIP is boun... | |
medium_convergence_05209 | CSNK2A1 and FBXL6 both interact with a shared protein. Evidence indicates that CK2 binds to DeltaCSN3(111-403) and CSN7, whereas PKD interacts with full-length CSN3. Which protein is encoded by the gene corresponding to this shared entity? | COP9 signalosome complex subunit 7a | Medium | convergence | {"qa_id":"medium_convergence_05209","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and FBXL6 both interact with a shared protein. Evidence indicates that CK2 binds to DeltaCSN3(111-403) and CSN7, whereas PKD interacts with full-leng... | |
medium_convergence_05210 | Primate erythroparvovirus 1 and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene. Evidence for this shared target in erythroid progenitor cells (from study GSE103460) reports a log2 fold change of 1.372 and an adjusted p-value of 0.04162. Which disease is associated with this gene a... | vitiligo | Medium | convergence | {"qa_id":"medium_convergence_05210","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Primate erythroparvovirus 1 and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene. Evidence for this shared target in ery... | |
medium_convergence_05211 | Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. In cytotoxic T-lymphocytes, experimental data for this gene shows a log2 fold change of approximately -1.28 and an adjusted p-value of 1.806e-05. Which protein does this gene product bind to? | TNC | Medium | convergence | {"qa_id":"medium_convergence_05211","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. In cytotoxic T-lymphocytes, experimental data for this gene shows a log2 fold ch... | |
medium_convergence_05212 | Measles morbillivirus and Human orthopneumovirus both upregulate a specific gene. Evidence for this gene in study GSE131840 reports a log2 fold change of 1.902 and an adjusted p-value of 0.03782. Which disease is associated with this gene as a biomarker? | type 1 diabetes mellitus 1 | Medium | convergence | {"qa_id":"medium_convergence_05212","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Human orthopneumovirus both upregulate a specific gene. Evidence for this gene in study GSE131840 reports a log2 fold change of 1.9... | |
medium_convergence_05213 | Both Vaccinia virus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.026 and an adjusted p-value of 0.0431. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_05213","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinoma cell... | |
medium_convergence_05214 | RASSF1 and AMOT share interaction partners. One such shared partner is involved in a pathway where the Angiomotin p130 isoform is phosphorylated on a conserved HXRXXS motif by Lats1/2 downstream of GPCR signaling. Which protein, among the shared interactors of RASSF1 and AMOT, is described in this context? | Serine/threonine-protein kinase LATS2 | Medium | convergence | {"qa_id":"medium_convergence_05214","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RASSF1 and AMOT share interaction partners. One such shared partner is involved in a pathway where the Angiomotin p130 isoform is phosphorylated on a conserv... | |
medium_convergence_05215 | TMOD4 and HSP90AA1 both interact with a shared protein. Experimental evidence indicates that this shared protein binds Hsp90, but unlike Cdc37, it does not bind Src family kinases or Raf-1. Which protein is encoded by the gene corresponding to this shared entity? | Hsp90 co-chaperone Cdc37-like 1 | Medium | convergence | {"qa_id":"medium_convergence_05215","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TMOD4 and HSP90AA1 both interact with a shared protein. Experimental evidence indicates that this shared protein binds Hsp90, but unlike Cdc37, it does not b... | |
medium_convergence_05217 | PRKN and MAPK8 share multiple interacting partners. One such partner is experimentally validated to associate with JNK1 in vivo in Jurkat T cells via coimmunoprecipitation and to bind JNK1 directly in yeast two-hybrid assays. Which disease is linked to this specific interacting partner through a biomarker relationship? | nodular sclerosis classical Hodgkin lymphoma | Medium | convergence | {"qa_id":"medium_convergence_05217","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and MAPK8 share multiple interacting partners. One such partner is experimentally validated to associate with JNK1 in vivo in Jurkat T cells via coimmun... | |
medium_convergence_05218 | HDAC1 and SAP30 both interact with a shared protein partner. Experimental evidence indicates that this partner forms a complex with Myt1, which was co-immunoprecipitated from transfected mammalian cells along with HDAC1 and HDAC2. Which protein is encoded by this shared partner? | Paired amphipathic helix protein Sin3b | Medium | convergence | {"qa_id":"medium_convergence_05218","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and SAP30 both interact with a shared protein partner. Experimental evidence indicates that this partner forms a complex with Myt1, which was co-immuno... | |
medium_convergence_05219 | FGF2 and FGF20 both interact with a specific shared receptor. Evidence indicates that FGF-2 binds well to this receptor, as well as to FGFR2, but interacts poorly with KGFR. Which protein is encoded by the gene corresponding to this shared receptor? | Fibroblast growth factor receptor 1 | Medium | convergence | {"qa_id":"medium_convergence_05219","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF2 and FGF20 both interact with a specific shared receptor. Evidence indicates that FGF-2 binds well to this receptor, as well as to FGFR2, but interacts p... | |
medium_convergence_05220 | CLSPN and GINS4 share common binding partners. One such shared partner is a DNA helicase subunit whose interaction with Claspin is lost upon Cdc7 inhibition. Which disease is associated with this specific shared partner? | autosomal dominant nonsyndromic hearing loss 70 | Medium | convergence | {"qa_id":"medium_convergence_05220","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLSPN and GINS4 share common binding partners. One such shared partner is a DNA helicase subunit whose interaction with Claspin is lost upon Cdc7 inhibition.... | |
medium_convergence_05221 | SCAP and SEC24C both interact with a specific transcription factor. Experimental evidence indicates that this transcription factor forms a complex with SCAP, which can be co-immunoprecipitated using antibodies against either protein. Which protein is encoded by the gene corresponding to this transcription factor? | Sterol regulatory element-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05221","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SCAP and SEC24C both interact with a specific transcription factor. Experimental evidence indicates that this transcription factor forms a complex with SCAP,... | |
medium_convergence_05222 | CSNK1G2 and APC both interact with a common protein partner. Experimental evidence indicates that this shared partner was co-precipitated with either GSK3beta or beta-catenin in both cell lines using immunoprecipitation. Which protein is encoded by this shared partner? | Glycogen synthase kinase-3 beta | Medium | convergence | {"qa_id":"medium_convergence_05222","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1G2 and APC both interact with a common protein partner. Experimental evidence indicates that this shared partner was co-precipitated with either GSK3bet... | |
medium_convergence_05223 | COPS5 and COMMD1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'The CSN subunit, CSN5, binds both the CODD of HIF-1 alpha and the pVHL tumor suppressor.' Which protein is connected to that entity through the 'encodes' relationship? | Hypoxia-inducible factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_05223","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and COMMD1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'The CSN subunit, CSN5, binds both the CODD ... | |
medium_convergence_05224 | GOLGA2 and LMAN1 each interact with a shared protein partner. Evidence indicates that one such partner is localized to the ERGIC through a direct, calcium-dependent interaction with LMAN1. Which protein is encoded by the gene corresponding to this specific partner? | Multiple coagulation factor deficiency protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05224","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GOLGA2 and LMAN1 each interact with a shared protein partner. Evidence indicates that one such partner is localized to the ERGIC through a direct, calcium-de... | |
medium_convergence_05225 | PRKACA and AKAP1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Analysis of ternary complexes by the yeast two-hybrid system revealed that RIalpha and RIbeta homodimers as well as an RIalpha:RIbeta heterodimer and several of the mutants were able to bi... | cAMP-dependent protein kinase type I-beta regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_05225","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKACA and AKAP1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Analysis of ternary compl... | |
medium_convergence_05226 | ORC1 and MCM10 share common binding partners. One such shared partner is described by evidence stating: 'Further analyses indicate that this protein physically interacts with ORC1 on non-chromatin nuclear structures.' Which protein is encoded by this specific shared partner? | Origin recognition complex subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_05226","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ORC1 and MCM10 share common binding partners. One such shared partner is described by evidence stating: 'Further analyses indicate that this protein physical... | |
medium_convergence_05227 | ESR1 and HSPA1A both interact with a shared protein. Evidence regarding this shared entity states: 'In vitro interaction studies revealed direct interaction of the TrxR1b with the estrogen receptors alpha and beta.' Which protein is encoded by this shared entity? | Thioredoxin reductase 1, cytoplasmic | Medium | convergence | {"qa_id":"medium_convergence_05227","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HSPA1A both interact with a shared protein. Evidence regarding this shared entity states: 'In vitro interaction studies revealed direct interaction ... | |
medium_convergence_05228 | KHDRBS1 and RFFL share a common interaction partner. Evidence indicates that this shared partner binds to Sam68 and Tap both in vivo and in vitro. Which protein is encoded by this shared interaction partner? | ATP-dependent RNA helicase A | Medium | convergence | {"qa_id":"medium_convergence_05228","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KHDRBS1 and RFFL share a common interaction partner. Evidence indicates that this shared partner binds to Sam68 and Tap both in vivo and in vitro. Which prot... | |
medium_convergence_05229 | CHD4 and CTBP1 both interact with a shared protein. Experimental evidence, including in vitro pull-down assays, in vivo interaction studies, and immunofluorescence combined with overexpression and RNA interference, demonstrates that this shared protein interacts with the transcriptional corepressor CTBP1. Which protein... | Pinin | Medium | convergence | {"qa_id":"medium_convergence_05229","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and CTBP1 both interact with a shared protein. Experimental evidence, including in vitro pull-down assays, in vivo interaction studies, and immunofluore... | |
medium_convergence_05230 | Human respirovirus 3 and Human immunodeficiency virus 1 both downregulate a specific gene. Experimental data for this gene in non-small cell lung adenocarcinoma cells (study GSE147507) shows a log2 fold change of approximately -2.165 and an adjusted p-value of 0.04216. Which cellular component is this gene located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_05230","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Human immunodeficiency virus 1 both downregulate a specific gene. Experimental data for this gene in non-small cell lung adenocarcin... | |
medium_convergence_05231 | STX6 and STX12 share common interaction partners. One such partner is identified by evidence stating: 'In vitro binding studies established that SNAP-23 binds to syntaxin 6.' Which cell type is this specific partner enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_05231","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STX6 and STX12 share common interaction partners. One such partner is identified by evidence stating: 'In vitro binding studies established that SNAP-23 bind... | |
medium_convergence_05233 | MDM2 and TP53 share multiple interacting partners. One such shared partner physically interacts with MDM2 and promotes ATM-mediated inhibitory phosphorylation of MDM2 following ionizing radiation. Which protein is encoded by the gene corresponding to this shared partner? | Nonsense-mediated mRNA decay factor SMG7 | Medium | convergence | {"qa_id":"medium_convergence_05233","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and TP53 share multiple interacting partners. One such shared partner physically interacts with MDM2 and promotes ATM-mediated inhibitory phosphorylatio... | |
medium_convergence_05234 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene in a lung fibroblast cell line (study GSE120891) reports a log2 fold change of approximately 2.48 and an adjusted p-value of approximately 0.047. Which ce... | mucosal-associated invariant T cell | Medium | convergence | {"qa_id":"medium_convergence_05234","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for t... | |
medium_convergence_05235 | PAK1 and PIK3R1 both interact with a shared protein. Evidence indicates that the interaction of TbetaRI with p85 was induced by treatment with TGFbeta. Which protein is encoded by the gene corresponding to this shared entity? | TGF-beta receptor type-1 | Medium | convergence | {"qa_id":"medium_convergence_05235","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PAK1 and PIK3R1 both interact with a shared protein. Evidence indicates that the interaction of TbetaRI with p85 was induced by treatment with TGFbeta. Which... | |
medium_convergence_05236 | Human alphaherpesvirus 3 and Human immunodeficiency virus 1 both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately -1.078 and an adjusted p-value of approximately 2.447e-06. Which biological process is this gene involved in? | response to X-ray | Medium | convergence | {"qa_id":"medium_convergence_05236","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Human immunodeficiency virus 1 both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study... | |
medium_convergence_05237 | SLC18A2 and STX1A share common binding partners. One such partner is described in a study stating: 'In the present study, several binding assays were used to demonstrate that Munc-18a significantly binds both isoforms of syntaxin 1 (syntaxins 1A and 1B).' Which protein is encoded by the gene corresponding to this share... | Syntaxin-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05237","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SLC18A2 and STX1A share common binding partners. One such partner is described in a study stating: 'In the present study, several binding assays were used to... | |
medium_convergence_05238 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 2.78 and an adjusted p-value of 0.04085. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05238","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2... | |
medium_convergence_05239 | FBXW11 and CUL1 both interact with a specific gene product. Evidence regarding this shared entity states: 'One central step controlling p100 processing consists in the interaction of the E3 ubiquitin ligase β-TrCP with p100, thereby leading to its ubiquitinylation and subsequent either complete degradation or partial p... | Nuclear factor NF-kappa-B p100 subunit | Medium | convergence | {"qa_id":"medium_convergence_05239","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and CUL1 both interact with a specific gene product. Evidence regarding this shared entity states: 'One central step controlling p100 processing consi... | |
medium_convergence_05240 | The epithelium of the lobar bronchus and the epithelium of the segmental bronchus share a common anatomical classification. Evidence regarding one of these shared entities states: 'The tissue made up of epithelial cells that lines the inside of the lobar bronchus.' Which anatomical entity is this shared classification ... | tracheobronchial epithelium | Medium | convergence | {"qa_id":"medium_convergence_05240","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The epithelium of the lobar bronchus and the epithelium of the segmental bronchus share a common anatomical classification. Evidence regarding one of these s... | |
medium_convergence_05241 | BCL6 and TP53 share a common interacting partner. Evidence indicates that this shared partner is targeted for ubiquitylation and proteasomal degradation by a SKP1–CUL1–F-box protein (SCF) ubiquitin ligase complex containing an orphan F-box protein. Which protein is encoded by this shared interacting partner? | F-box only protein 11 | Medium | convergence | {"qa_id":"medium_convergence_05241","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BCL6 and TP53 share a common interacting partner. Evidence indicates that this shared partner is targeted for ubiquitylation and proteasomal degradation by a... | |
medium_convergence_05242 | CENPA and CENPW each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified this protein.' Which disease is associated with this protein? | astrocytoma (excluding glioblastoma) | Medium | convergence | {"qa_id":"medium_convergence_05242","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPW each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosoma... | |
medium_convergence_05243 | ALPK2 and PTK2 are both associated with multiple shared biological processes. A specific study highlights ALPK2 as a candidate negative regulator of WNT/β-catenin signaling in cardiogenesis. Which biological process, linked to ALPK2 via an 'is_a' relationship, is most consistent with this context of heart development? | animal organ morphogenesis | Medium | convergence | {"qa_id":"medium_convergence_05243","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALPK2 and PTK2 are both associated with multiple shared biological processes. A specific study highlights ALPK2 as a candidate negative regulator of WNT/β-ca... | |
medium_convergence_05244 | Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both associated with the downregulation of a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of -1.222 and an adjusted p-value of 0.01915. Which protein is encoded by this gene? | Transgelin | Medium | convergence | {"qa_id":"medium_convergence_05244","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both associated with the downregulation of a specific gene. Experimental data for this gene in a mo... | |
medium_convergence_05245 | CHD4 and CDC37 both interact with a shared protein. Evidence indicates that this shared protein directly associates with CK2alpha in an E. coli system. Which protein product is encoded by this shared gene? | Casein kinase II subunit alpha | Medium | convergence | {"qa_id":"medium_convergence_05245","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and CDC37 both interact with a shared protein. Evidence indicates that this shared protein directly associates with CK2alpha in an E. coli system. Which... | |
medium_convergence_05246 | CSK and EGFR share multiple interacting partners. One such partner is described by the evidence: 'We have found that a major interaction also exists between beta-arrestin1 and the catalytic or kinase domain (SH1) of c-SRC.' Which cell type is this specific partner enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_05246","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSK and EGFR share multiple interacting partners. One such partner is described by the evidence: 'We have found that a major interaction also exists between ... | |
medium_convergence_05248 | DCANP1 and HOXA1 are both involved in more than one shared biological process. One such shared process is associated with a phenotype characterized by horizontal gaze abnormalities, deafness, facial weakness, hypoventilation, vascular malformations of the internal carotid arteries and cardiac outflow tract, mental reta... | internal ear | Medium | convergence | {"qa_id":"medium_convergence_05248","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCANP1 and HOXA1 are both involved in more than one shared biological process. One such shared process is associated with a phenotype characterized by horizo... | |
medium_convergence_05249 | STUB1 and HDAC2 both interact with a specific shared protein. Evidence indicates that STUB1 interacts with this protein to promote its K48-linked polyubiquitination in an Hsp70-dependent manner. Which protein is encoded by the gene corresponding to this shared interaction partner? | Forkhead box protein P3 | Medium | convergence | {"qa_id":"medium_convergence_05249","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and HDAC2 both interact with a specific shared protein. Evidence indicates that STUB1 interacts with this protein to promote its K48-linked polyubiquit... | |
medium_convergence_05250 | OPTN and IKBKG both interact with a shared protein. Experimental evidence for this interaction indicates that it was confirmed by co-immunoprecipitation and found to be abrogated by panr2. Which protein is encoded by the gene corresponding to this shared entity? | Sharpin | Medium | convergence | {"qa_id":"medium_convergence_05250","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OPTN and IKBKG both interact with a shared protein. Experimental evidence for this interaction indicates that it was confirmed by co-immunoprecipitation and ... | |
medium_convergence_05251 | Human betaherpesvirus 5 and Pegivirus C both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of 1.423 and an adjusted p-value of 0.006819. In which cell type is this gene enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05251","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Pegivirus C both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of 1.423 and an adjusted ... | |
medium_convergence_05252 | AP2A2 and AAK1 both interact with a specific protein. Evidence regarding this protein states: 'The central region of epsin binds AP-2 and its carboxy-terminal region binds Eps15.' Which disease is associated with this protein? | colon carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05252","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2A2 and AAK1 both interact with a specific protein. Evidence regarding this protein states: 'The central region of epsin binds AP-2 and its carboxy-termina... | |
medium_convergence_05253 | EFNB1 and EPHB2 share common binding partners. One such partner is implicated in a study stating: 'Here we show that the SH2/SH3 domain adaptor protein Grb4 binds to the cytoplasmic domain of B ephrins in a phosphotyrosine-dependent manner.' Which protein is encoded by the gene corresponding to this shared binding part... | Cytoplasmic protein NCK2 | Medium | convergence | {"qa_id":"medium_convergence_05253","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EFNB1 and EPHB2 share common binding partners. One such partner is implicated in a study stating: 'Here we show that the SH2/SH3 domain adaptor protein Grb4 ... | |
medium_convergence_05254 | YAP1 and CREBBP share multiple interacting partners. One such shared partner is described by evidence stating: 'Coexpression of CREB-binding protein (CBP)/p300 with a specific protein has an additive effect on promoter activity, and the proteins were demonstrated to interact physically.' Which gene interacts with this ... | MIDEAS | Medium | convergence | {"qa_id":"medium_convergence_05254","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and CREBBP share multiple interacting partners. One such shared partner is described by evidence stating: 'Coexpression of CREB-binding protein (CBP)/p3... | |
medium_convergence_05255 | EGFR and ERBB2 both interact with a specific shared gene product. Evidence regarding one such shared entity states: 'Here, we report that the expression of this kinase was observed in 70 out of 80 primary breast cancer specimens but not in normal breast tissues (0/19).' Which protein is encoded by the gene correspondin... | Megakaryocyte-associated tyrosine-protein kinase | Medium | convergence | {"qa_id":"medium_convergence_05255","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ERBB2 both interact with a specific shared gene product. Evidence regarding one such shared entity states: 'Here, we report that the expression of t... | |
medium_convergence_05256 | CSNK1E and KMT2A both interact with a shared circadian regulator. Evidence indicates that mammalian CKIepsilon binds to and phosphorylates the murine circadian regulator mPER1. Which protein is encoded by this shared entity? | Period circadian protein homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_05256","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1E and KMT2A both interact with a shared circadian regulator. Evidence indicates that mammalian CKIepsilon binds to and phosphorylates the murine circadi... | |
medium_convergence_05257 | RHOA and NRAS both interact with a specific shared gene product. Contextual evidence indicates that this entity, along with KRas and Rac1, acts as a substrate for a guanine nucleotide exchange factor, binding to it in both active and inactive forms, a process requiring poly-basic residues in the C-termini of the GTPase... | T-cell adult acute lymphocytic leukemia | Medium | convergence | {"qa_id":"medium_convergence_05257","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOA and NRAS both interact with a specific shared gene product. Contextual evidence indicates that this entity, along with KRas and Rac1, acts as a substrat... | |
medium_convergence_05258 | Human alphaherpesvirus 1 and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.187 and an adjusted p-value of 0.002873. Which disease is associated with this gene as a biomarker? | seasonal allergic rhinitis | Medium | convergence | {"qa_id":"medium_convergence_05258","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_05259 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gene exhibited a log2 fold change of approximately -1.285 and an adjusted p-value of 0.005856. Which protein is encoded by this gene? | Zinc finger matrin-type protein 3 | Medium | convergence | {"qa_id":"medium_convergence_05259","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gen... | |
medium_convergence_05260 | KDM1A and HIF1A share multiple protein interaction partners. One such shared partner is identified in evidence stating: 'Results from co-association studies revealed a protein encoded by the gene CBFA2T3 to interact with HIF1α.' Which protein is encoded by the gene corresponding to this shared interaction partner? | Transcriptional corepressor CBFA2T3 | Medium | convergence | {"qa_id":"medium_convergence_05260","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KDM1A and HIF1A share multiple protein interaction partners. One such shared partner is identified in evidence stating: 'Results from co-association studies ... | |
medium_convergence_05261 | SIRT1 and HIF1A both interact with a specific shared protein. Evidence indicates that this protein acts as a molecular platform, interacting directly with HIF-1α, PHD, and VHL to mediate the O2-dependent degradation of HIF-1α. Which cell type is this protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05261","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIRT1 and HIF1A both interact with a specific shared protein. Evidence indicates that this protein acts as a molecular platform, interacting directly with HI... | |
medium_convergence_05262 | KLF3 and RBBP4 both interact with a shared gene product. Experimental evidence indicates that RBBP4 binds to the N-terminal amino acid residues of PRDM3 and this shared entity, with a dissociation constant of 3.0 μM, as measured by isothermal titration calorimetry. Which gene does this shared entity interact with? | MTA1 | Medium | convergence | {"qa_id":"medium_convergence_05262","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KLF3 and RBBP4 both interact with a shared gene product. Experimental evidence indicates that RBBP4 binds to the N-terminal amino acid residues of PRDM3 and ... | |
medium_convergence_05263 | PARP1 and MEN1 share multiple interacting partners. Experimental evidence indicates that one specific shared partner, along with Cenpa and Cenpb (but not Cenpc), interacts with PARP-1 and undergoes poly(ADP-ribosyl)ation following DNA damage induction. Which disease is associated with this specific shared partner? | aneuploidy | Medium | convergence | {"qa_id":"medium_convergence_05263","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and MEN1 share multiple interacting partners. Experimental evidence indicates that one specific shared partner, along with Cenpa and Cenpb (but not Cen... | |
medium_convergence_05264 | SKP1 and RBX1 each interact with more than one shared partner. Evidence concerning one shared entity reports that this entity is an F-box protein that forms the SCF complex with SKP1 and Cullin-1 to constitute an E3 ligase for ubiquitylation. Which cellular component is connected to that entity through the 'located in'... | SCF ubiquitin ligase complex | Medium | convergence | {"qa_id":"medium_convergence_05264","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SKP1 and RBX1 each interact with more than one shared partner. Evidence concerning one shared entity reports that this entity is an F-box protein that forms ... | |
medium_convergence_05265 | HIPK2 and MYC both interact with a shared protein. Evidence regarding one such shared partner states: 'Here, we report that homeodomain-interacting protein kinase-2 (HIPK2) forms a complex with a transcription factor and p300, and phosphorylates both the transcription factor and p300 to stimulate transcription activati... | Runt-related transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_05265","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIPK2 and MYC both interact with a shared protein. Evidence regarding one such shared partner states: 'Here, we report that homeodomain-interacting protein k... | |
medium_convergence_05266 | Cardiovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately 1.28 and an adjusted p-value of approximately 0.019. Which disease is associated with genomic alterations in this gene? | myelodysplastic syndrome | Medium | convergence | {"qa_id":"medium_convergence_05266","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cardiovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) ... | |
medium_convergence_05267 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.15 and an adjusted p-value of approximately 0.0186. Which disease is causally linked to this gene? | congestive heart failure | Medium | convergence | {"qa_id":"medium_convergence_05267","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (stud... | |
medium_convergence_05268 | CHUK and STAT1 both interact with a shared protein. Experimental evidence indicates that this shared protein directly interacts with TNFR1 and STAT1, but does not interact with FADD. Which cell type is enriched for this shared protein? | CD4-positive, alpha-beta memory T cell | Medium | convergence | {"qa_id":"medium_convergence_05268","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and STAT1 both interact with a shared protein. Experimental evidence indicates that this shared protein directly interacts with TNFR1 and STAT1, but doe... | |
medium_convergence_05269 | HDAC1 and PLK1 share a common interacting partner. Evidence indicates that this shared partner binds to HDAC1 and downregulates it by inducing its polyubiquitylation, both in vitro and in vivo. Which protein product is encoded by this shared interacting partner? | E3 ubiquitin-protein ligase CHFR | Medium | convergence | {"qa_id":"medium_convergence_05269","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and PLK1 share a common interacting partner. Evidence indicates that this shared partner binds to HDAC1 and downregulates it by inducing its polyubiqui... | |
medium_convergence_05270 | YWHAQ and AKT1 share multiple interacting partners. One such partner is part of a complex that directly phosphorylates Akt/PKB on Ser473 in vitro and facilitates Thr308 phosphorylation by PDK1. Which cell type is this specific partner enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05270","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and AKT1 share multiple interacting partners. One such partner is part of a complex that directly phosphorylates Akt/PKB on Ser473 in vitro and facilit... | |
medium_convergence_05271 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene in lung fibroblast cell lines (study GSE120891) reports a log2 fold change of approximately 2.48 and an adjusted p-value of approximately 0.047. Which cel... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_05271","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for t... | |
medium_convergence_05273 | MDM2 and ACE2 share common interacting partners. One such shared partner is distinguished by the fact that its N-terminal region binds to the central acidic domain of MDM2. Which disease is associated with this specific shared partner? | Diamond-Blackfan anemia 17 | Medium | convergence | {"qa_id":"medium_convergence_05273","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and ACE2 share common interacting partners. One such shared partner is distinguished by the fact that its N-terminal region binds to the central acidic ... | |
medium_convergence_05275 | HERC5 and EIF4E2 both interact with a specific shared protein. Evidence indicates that this shared protein is the substrate conjugated by HERC5, which acts as the main cellular E3 ligase for this IFN-induced protein. Which protein is encoded by the gene corresponding to this shared entity? | Ubiquitin-like protein ISG15 | Medium | convergence | {"qa_id":"medium_convergence_05275","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HERC5 and EIF4E2 both interact with a specific shared protein. Evidence indicates that this shared protein is the substrate conjugated by HERC5, which acts a... | |
medium_convergence_05276 | CHEK1 and SUPT16H share common interacting partners. One such partner is identified in a study reporting the identification of the heterohexamic minichromosome maintenance (MCM) complex that interacts with Chk1 by mass spectrometry. Which protein is encoded by this specific shared interacting partner? | DNA replication licensing factor MCM4 | Medium | convergence | {"qa_id":"medium_convergence_05276","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and SUPT16H share common interacting partners. One such partner is identified in a study reporting the identification of the heterohexamic minichromoso... | |
medium_convergence_05278 | Both the negative regulation of bile acid biosynthetic process and the negative regulation of testosterone biosynthetic process are subtypes of a shared biological process. Evidence regarding this shared process states: 'Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reaction... | steroid biosynthetic process | Medium | convergence | {"qa_id":"medium_convergence_05278","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the negative regulation of bile acid biosynthetic process and the negative regulation of testosterone biosynthetic process are subtypes of a shared biol... | |
medium_convergence_05279 | Both Human orthopneumovirus and Human immunodeficiency virus 1 are associated with the upregulation of a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.46 and an adjusted p-value of 0.047. Which protein is encoded by this ge... | Desmin | Medium | convergence | {"qa_id":"medium_convergence_05279","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Human immunodeficiency virus 1 are associated with the upregulation of a specific gene. Experimental data for this gene in cy... | |
medium_convergence_05280 | GNA12 and GNAQ each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that WDR36 co-immunoprecipitated with Gαq and promoted the interaction between TPβ and Gαq. Which protein is encoded by the gene corresponding to that shared partner? | Thromboxane A2 receptor | Medium | convergence | {"qa_id":"medium_convergence_05280","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA12 and GNAQ each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that WDR36 co-immunoprecipitate... | |
medium_convergence_05281 | Orthohepevirus A and Primate bocaparvovirus 1 both downregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of -1.165 and an adjusted p-value of 0.04032. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05281","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Orthohepevirus A and Primate bocaparvovirus 1 both downregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) report... | |
medium_convergence_05283 | DDX47 and IMP4 both interact with a specific shared protein partner. Evidence regarding this partner states: 'In addition, we have found that hImp3, hImp4 and hMpp10 can form a stable hetero-trimeric complex in vitro, which is generated by direct interactions of both hImp3 and hImp4 with hMpp10.' Which protein is encod... | U3 small nucleolar ribonucleoprotein protein MPP10 | Medium | convergence | {"qa_id":"medium_convergence_05283","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX47 and IMP4 both interact with a specific shared protein partner. Evidence regarding this partner states: 'In addition, we have found that hImp3, hImp4 an... | |
medium_convergence_05285 | Erythromycin and Palonosetron both interact with a specific drug. Evidence regarding this shared drug highlights pharmacological interactions with other medications metabolized by the cytochrome P450 3A4 (CYP3A4) isoform, specifically mentioning azole antifungals and HIV protease inhibitors. Which disease is this share... | erectile dysfunction | Medium | convergence | {"qa_id":"medium_convergence_05285","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Erythromycin and Palonosetron both interact with a specific drug. Evidence regarding this shared drug highlights pharmacological interactions with other medi... | |
medium_convergence_05286 | Human respirovirus 3 and Influenza A virus both upregulate a specific gene. Evidence for this gene in a non-small cell lung adenocarcinoma cell line reports a log2 fold change of 1.249 and an adjusted p-value of 0.03663. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05286","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Influenza A virus both upregulate a specific gene. Evidence for this gene in a non-small cell lung adenocarcinoma cell line reports ... | |
medium_convergence_05287 | Human polyomavirus 2 and Influenza A virus both upregulate a specific host gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of 1.012 and an adjusted p-value of 0.0339. What protein is encoded by this gene? | Ras and Rab interactor 2 | Medium | convergence | {"qa_id":"medium_convergence_05287","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 2 and Influenza A virus both upregulate a specific host gene. Experimental data for this gene in renal epithelial cells (study GSE135833) ... | |
medium_convergence_05289 | DAXX and HIST1H4A each interact with more than one shared protein. Evidence concerning one shared entity reports that its recruitment to ND10 from condensed chromatin requires a small ubiquitin-related modifier (SUMO-1) modification of this entity and reflects the interaction between the COOH-terminal domain of DAXX an... | Protein PML | Medium | convergence | {"qa_id":"medium_convergence_05289","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and HIST1H4A each interact with more than one shared protein. Evidence concerning one shared entity reports that its recruitment to ND10 from condensed ... | |
medium_convergence_05290 | Atenolol and Levobunolol (ophthalmic) share a common interacting drug. Evidence regarding this shared entity states: 'The selective beta-blocker atenolol showed a tendency to improve the FBF response to MCh (from 28.8 +/- 9.2 to 32.6 +/- 8.7 ml/min/ml tissue, p < 0.05).' Identify the drug that interacts with this share... | Amifampridine | Medium | convergence | {"qa_id":"medium_convergence_05290","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Atenolol and Levobunolol (ophthalmic) share a common interacting drug. Evidence regarding this shared entity states: 'The selective beta-blocker atenolol sho... | |
medium_convergence_05291 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of approximately 1.208 and an adjusted p-value of 0.02262. Which disease is associated with this gene? | glioma | Medium | convergence | {"qa_id":"medium_convergence_05291","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific gene. Experimental data for this gene in h... | |
medium_convergence_05292 | CHUK and PRKN share multiple interacting partners. One such shared partner is described by the evidence: 'We report here that alphaPKC as well as the atypical PKCs bind to the IKKs in vitro and in vivo.' Which cell type is this specific shared partner enriched in? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_05292","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and PRKN share multiple interacting partners. One such shared partner is described by the evidence: 'We report here that alphaPKC as well as the atypica... | |
medium_convergence_05293 | EP300 and EGLN1 both interact with a specific transcription factor. Evidence indicates that while CBP can bind to HIF-2α independent of its C-terminal activation domain via enzyme/substrate interactions, p300 only complexes with HIF-2α through this C-terminal activation domain. Based on this evidence identifying the sh... | transcription regulator complex | Medium | convergence | {"qa_id":"medium_convergence_05293","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and EGLN1 both interact with a specific transcription factor. Evidence indicates that while CBP can bind to HIF-2α independent of its C-terminal activa... | |
medium_convergence_05294 | ACTR3 and CHRM2 both interact with a shared protein partner. Evidence regarding this partner states: 'The NTA region interacts directly with the Arp2/3 complex based on affinity chromatography, immunoprecipitation assays, and binding assays using purified components.' Which protein is encoded by the gene corresponding ... | Src substrate cortactin | Medium | convergence | {"qa_id":"medium_convergence_05294","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR3 and CHRM2 both interact with a shared protein partner. Evidence regarding this partner states: 'The NTA region interacts directly with the Arp2/3 compl... | |
medium_convergence_05295 | YWHAQ and CREBBP both interact with a specific shared protein. Evidence indicates that CBP directly acetylates and inhibits the kinase activity of this shared protein. Which protein is encoded by the gene corresponding to this shared entity? | Serine/threonine-protein kinase MARK2 | Medium | convergence | {"qa_id":"medium_convergence_05295","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and CREBBP both interact with a specific shared protein. Evidence indicates that CBP directly acetylates and inhibits the kinase activity of this share... | |
medium_convergence_05296 | Both Measles morbillivirus and Cardiovirus A are reported to upregulate a specific gene. Evidence for this shared target indicates a log2 fold change of approximately 1.33 and an adjusted p-value of approximately 0.029. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05296","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are reported to upregulate a specific gene. Evidence for this shared target indicates a log2 fold change of appr... | |
medium_convergence_05298 | Human betaherpesvirus 5 and Human polyomavirus 1 both upregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines reports a log2 fold change of 1.352 and an adjusted p-value of 0.02854. Which molecular function is enabled by this gene? | sequence-specific double-stranded DNA binding | Medium | convergence | {"qa_id":"medium_convergence_05298","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human polyomavirus 1 both upregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines reports a log2 fol... | |
medium_convergence_05299 | Rhinovirus A and Primate bocaparvovirus 1 both upregulate a shared gene. Evidence for one such shared target reports a log2 fold change of 1.345 and an adjusted p-value of 0.0001831. Which protein is encoded by that gene? | Interleukin-1 receptor-associated kinase-like 2 | Medium | convergence | {"qa_id":"medium_convergence_05299","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Primate bocaparvovirus 1 both upregulate a shared gene. Evidence for one such shared target reports a log2 fold change of 1.345 and an adjus... | |
medium_convergence_05300 | CDC73 and EAF1 both interact with a shared protein partner. Experimental evidence indicates that endogenous EAF1 and this shared partner were co-immunoprecipitated from multiple cell lines using specific antibodies. Which disease is associated with this shared protein partner? | myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_05300","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC73 and EAF1 both interact with a shared protein partner. Experimental evidence indicates that endogenous EAF1 and this shared partner were co-immunoprecip... | |
medium_convergence_05301 | CREBBP and HDAC1 both interact with a shared protein. Evidence regarding this protein states: 'We further demonstrate that transactivation by FG repeat-rich segments of this protein correlates with their ability to interact functionally and physically with the transcriptional coactivators CREB binding protein (CBP) and... | Nuclear pore complex protein Nup98-Nup96 | Medium | convergence | {"qa_id":"medium_convergence_05301","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and HDAC1 both interact with a shared protein. Evidence regarding this protein states: 'We further demonstrate that transactivation by FG repeat-rich ... | |
medium_convergence_05302 | DCUN1D3 and CUL1 both interact with a shared protein. Evidence regarding this shared entity states: 'The evolutionarily conserved protein [ENTITY] acts as a substrate receptor for the SKP1-cullin-1-RBX1 ubiquitin ligase.' Which protein is encoded by this entity? | F-box only protein 9 | Medium | convergence | {"qa_id":"medium_convergence_05302","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCUN1D3 and CUL1 both interact with a shared protein. Evidence regarding this shared entity states: 'The evolutionarily conserved protein [ENTITY] acts as a ... | |
medium_convergence_05303 | FGF1 and FGF20 both interact with a specific receptor protein. Experimental evidence indicates that this receptor forms complexes with acidic FGF (FGF-1) and basic FGF (FGF-2) in solution, regardless of the presence of heparin. Which protein is encoded by the gene corresponding to this receptor? | Fibroblast growth factor receptor 4 | Medium | convergence | {"qa_id":"medium_convergence_05303","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF1 and FGF20 both interact with a specific receptor protein. Experimental evidence indicates that this receptor forms complexes with acidic FGF (FGF-1) and... | |
medium_convergence_05304 | DDIT3 and MYC share multiple interacting partners. One such shared partner is a mammalian tribbles homolog that functions as a repressor of CHOP, interacts with CHOP via its N-terminal portion, and significantly blocks the association of p300 with CHOP. Which disease is associated with this specific entity? | thymoma | Medium | convergence | {"qa_id":"medium_convergence_05304","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDIT3 and MYC share multiple interacting partners. One such shared partner is a mammalian tribbles homolog that functions as a repressor of CHOP, interacts w... | |
medium_convergence_05305 | Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are associated with the downregulation of a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.101 and an adjusted p-value of 3.622e-05. Which protein is encoded by this ... | BRI3-binding protein | Medium | convergence | {"qa_id":"medium_convergence_05305","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are associated with the downregulation of a specific gene. Experimental data for this gene i... | |
medium_convergence_05306 | TEX10 and LAS1L both interact with a shared protein. Evidence regarding this shared protein states: 'In this paper, we demonstrate that LAS1L interacts with PELP1, TEX10, and [the shared protein], the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 and SENP3, to form a novel nucleolar complex th... | WD repeat-containing protein 18 | Medium | convergence | {"qa_id":"medium_convergence_05306","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TEX10 and LAS1L both interact with a shared protein. Evidence regarding this shared protein states: 'In this paper, we demonstrate that LAS1L interacts with ... | |
medium_convergence_05307 | FOXE3 and WNT9A are both involved in multiple shared biological processes. One of these shared processes is associated with an entity where evidence indicates that most tissues of the anterior segment—specifically the iris, cornea, ciliary body, and trabecular meshwork—are malformed or exhibit differentiation defects. ... | anatomical structure morphogenesis | Medium | convergence | {"qa_id":"medium_convergence_05307","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOXE3 and WNT9A are both involved in multiple shared biological processes. One of these shared processes is associated with an entity where evidence indicate... | |
medium_convergence_05308 | GLI2 and GLI3 both physically interact with a specific shared protein. Evidence indicates that this protein, known as HSu(fu) in Drosophila, represses the activity of the zinc-finger transcription factor Gli (which mediates Hedgehog signaling in vertebrates) and physically interacts with Gli, Gli2, and Gli3. Additional... | ULK3 | Medium | convergence | {"qa_id":"medium_convergence_05308","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GLI2 and GLI3 both physically interact with a specific shared protein. Evidence indicates that this protein, known as HSu(fu) in Drosophila, represses the ac... | |
medium_convergence_05309 | Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately -2.39 and an adjusted p-value of approximately 0.041. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05309","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475... | |
medium_convergence_05310 | TAP1 and TAP2 both enable a specific molecular function. Evidence regarding one of these functions states: 'At the same time TAP is arrested in a peptide transport incompetent conformation, although ATP and peptide binding to TAP are not affected.' Which molecular function is this, and what is its immediate parent term... | transmembrane transporter activity | Medium | convergence | {"qa_id":"medium_convergence_05310","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TAP1 and TAP2 both enable a specific molecular function. Evidence regarding one of these functions states: 'At the same time TAP is arrested in a peptide tra... | |
medium_convergence_05311 | Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene shows a log2 fold change of approximately 2.21 and an adjusted p-value of 0.0027. Which disease is associated with this gene as a biomarker? | intestinal obstruction | Medium | convergence | {"qa_id":"medium_convergence_05311","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene shows a log2 fold change of approximately 2.21 and an adjusted p-value... | |
medium_convergence_05312 | COPS5 and CSNK2A1 both interact with a shared protein. Evidence indicates that phosphorylation of this protein at Thr285 and Thr290 by CK2 disrupts its binding to the speckle-type POZ protein (an adaptor for the CUL3 ubiquitin E3 ligase complex), thereby protecting it from CUL3-mediated proteasomal degradation. Which d... | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_05312","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and CSNK2A1 both interact with a shared protein. Evidence indicates that phosphorylation of this protein at Thr285 and Thr290 by CK2 disrupts its bindi... | |
medium_convergence_05313 | STUB1 and XRCC6 both interact with a common protein. Evidence regarding this shared partner indicates that monoubiquitination of CHIP by Ube2w stabilizes the interaction between CHIP and this protein, which, through its deubiquitinase (DUB) activity, limits the length of ubiquitin chains attached to CHIP substrates. Wh... | Ataxin-3 | Medium | convergence | {"qa_id":"medium_convergence_05313","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and XRCC6 both interact with a common protein. Evidence regarding this shared partner indicates that monoubiquitination of CHIP by Ube2w stabilizes the... |
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