qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_convergence_05314 | Cardiovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately 2.18 and an adjusted p-value of 0.0116. Which disease is associated with this gene as a biomarker? | congenital heart disease | Medium | convergence | {"qa_id":"medium_convergence_05314","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cardiovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) report... | |
medium_convergence_05315 | MAP2K1 and BRAF both interact with a shared protein. Biochemical evidence indicates that residues Raf-Arg59 and Raf-Arg67 from the Raf RBD domain interact with Ras-Glu37 in the Ras effector region. Which cell type is this shared protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05315","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP2K1 and BRAF both interact with a shared protein. Biochemical evidence indicates that residues Raf-Arg59 and Raf-Arg67 from the Raf RBD domain interact wi... | |
medium_convergence_05316 | Both Human alphaherpesvirus 1 and Hepacivirus C are reported to downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.455 and an adjusted p-value of 0.002513. Which protein is encoded by this gene? | Acyl-coenzyme A synthetase ACSM3, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_05316","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Hepacivirus C are reported to downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell li... | |
medium_convergence_05317 | MDM2 and PCM1 both interact with a common protein partner. Experimental evidence for one such partner states: 'In the presence of proteasome inhibitors, we detected a stable complex of this partner with MDM2 at the nucleus.' Which protein is encoded by this specific partner? | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_05317","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and PCM1 both interact with a common protein partner. Experimental evidence for one such partner states: 'In the presence of proteasome inhibitors, we d... | |
medium_convergence_05318 | STUB1 and EMD both interact with a shared protein entity. Experimental evidence indicates that upon treatment with 17-AAG, this specific entity associates with the co-chaperone HSP70 and the ubiquitin E3 ligase CHIP. Which disease is therapeutically linked to this entity? | non-small cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05318","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and EMD both interact with a shared protein entity. Experimental evidence indicates that upon treatment with 17-AAG, this specific entity associates wi... | |
medium_convergence_05319 | GRB2 and GRAP2 both interact with a specific protein. Experimental evidence indicates that the binding of GRB2 to this protein is dependent on intact phosphorylation sites Y703 and Y936. Which cellular component is this protein located in? | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_05319","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and GRAP2 both interact with a specific protein. Experimental evidence indicates that the binding of GRB2 to this protein is dependent on intact phospho... | |
medium_convergence_05320 | BIRC2 and IFIH1 both interact with a specific protein. Evidence regarding this protein states: 'A cIAP1/cIAP2/TRAF2 E3 ligase complex binds to and ubiquitinates IKKε.' Which protein is encoded by the gene corresponding to this entity? | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | Medium | convergence | {"qa_id":"medium_convergence_05320","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and IFIH1 both interact with a specific protein. Evidence regarding this protein states: 'A cIAP1/cIAP2/TRAF2 E3 ligase complex binds to and ubiquitina... | |
medium_convergence_05321 | AIF1 and CXCL10 are both associated with more than one shared biological process. One piece of evidence indicates that MOLT-4 cells overexpressing AIF-1 migrated 95% more rapidly than empty vector controls. Which biological process, linked to this specific evidence, is defined as positively regulating a downstream cell... | T cell migration | Medium | convergence | {"qa_id":"medium_convergence_05321","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AIF1 and CXCL10 are both associated with more than one shared biological process. One piece of evidence indicates that MOLT-4 cells overexpressing AIF-1 migr... | |
medium_convergence_05322 | LRPPRC and WDR5 both interact with a specific shared gene product. Experimental evidence indicates that this shared entity forms a protein complex at the MDM2 promoter together with the protein encoded by MYCN (but not p53), resulting in histone H3K4 trimethylation and the activation of MDM2 transcription. Which protei... | N-myc proto-oncogene protein | Medium | convergence | {"qa_id":"medium_convergence_05322","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LRPPRC and WDR5 both interact with a specific shared gene product. Experimental evidence indicates that this shared entity forms a protein complex at the MDM... | |
medium_convergence_05323 | EIF3B and EIF3C both interact with a shared protein. Evidence indicates that activating mTOR signaling with insulin increases the amount of this protein bound to eIF3 by as much as five-fold. Which disease is associated with this protein as a biomarker? | myocardial ischemia | Medium | convergence | {"qa_id":"medium_convergence_05323","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3B and EIF3C both interact with a shared protein. Evidence indicates that activating mTOR signaling with insulin increases the amount of this protein boun... | |
medium_convergence_05324 | The genes DMD and AGRN both encode proteins that interact with a common partner. Experimental evidence, including Yeast two-hybrid assays and pull-down studies, indicates that this shared partner binds to the C-terminal region of dystrophin and related proteins. Which protein is encoded by the gene representing this sh... | Gamma-2-syntrophin | Medium | convergence | {"qa_id":"medium_convergence_05324","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The genes DMD and AGRN both encode proteins that interact with a common partner. Experimental evidence, including Yeast two-hybrid assays and pull-down studi... | |
medium_convergence_05325 | Both Human betaherpesvirus 5 and Zaire ebolavirus are known to downregulate a specific host gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately -1.05 and an adjusted p-value of 0.0022. Which protein is encoded by this gene? | Dehydrogenase/reductase SDR family member 11 | Medium | convergence | {"qa_id":"medium_convergence_05325","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Zaire ebolavirus are known to downregulate a specific host gene. Experimental data for this gene in foreskin fibroblast cell... | |
medium_convergence_05326 | CTBP1 and ZMYM2 share a common interaction partner. Evidence regarding this partner states: 'Screening for proteins that interact with subdomains 1 and 2 of this protein using yeast two-hybrid analysis revealed that subdomain 2 binds to C-terminal binding protein 1, which can synergistically repress transcription with ... | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_05326","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and ZMYM2 share a common interaction partner. Evidence regarding this partner states: 'Screening for proteins that interact with subdomains 1 and 2 of ... | |
medium_convergence_05327 | FKBP5 and HSP90AA1 share multiple interacting partners. One such partner is a kinase whose activity depends on its interaction with HSP90-1beta, HSC70, and HSP70 proteins. Which cellular component is this specific kinase located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_05327","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FKBP5 and HSP90AA1 share multiple interacting partners. One such partner is a kinase whose activity depends on its interaction with HSP90-1beta, HSC70, and H... | |
medium_convergence_05328 | BIRC3 and RNF31 both interact with a common protein. Evidence indicates that this shared protein interacts via its PUB domain with CYLD, and a PUB interaction motif (PIM) within this protein binds to the PUB domain of the LUBAC component HOIP. Which disease is associated with this protein through genomic alterations? | brain neoplasm | Medium | convergence | {"qa_id":"medium_convergence_05328","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and RNF31 both interact with a common protein. Evidence indicates that this shared protein interacts via its PUB domain with CYLD, and a PUB interactio... | |
medium_convergence_05329 | DBF4 and GINS3 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'We also identified an interaction between MCM-BP and the Dbf4 regulatory component of the DDK kinase in both yeast 2-hybrid and insect cell co-expression assays, and this interaction was verified by... | DNA replication licensing factor MCM7 | Medium | convergence | {"qa_id":"medium_convergence_05329","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DBF4 and GINS3 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'We also identified an interaction b... | |
medium_convergence_05330 | SMG1 and TRRAP both interact with a specific protein. Evidence indicates that this protein interacts with and stabilizes all six members of the PIKK family of proteins (mTOR, ATM, ATR, DNA-PKcs, SMG-1, and TRRAP). Which protein is encoded by the gene corresponding to this stabilizing entity? | TELO2-interacting protein 1 homolog | Medium | convergence | {"qa_id":"medium_convergence_05330","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMG1 and TRRAP both interact with a specific protein. Evidence indicates that this protein interacts with and stabilizes all six members of the PIKK family o... | |
medium_convergence_05331 | Sorafenib and Nilutamide both interact with a specific third drug. Evidence regarding this shared interaction partner states: 'The two-way combination of the drugs led to additive interactions while the combination of the three drugs showed synergistic action.' Which disease is this shared drug indicated for? | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_05331","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Sorafenib and Nilutamide both interact with a specific third drug. Evidence regarding this shared interaction partner states: 'The two-way combination of the... | |
medium_convergence_05332 | DMD and LAMA1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Finally, we used in vitro translated proteins in an immunoprecipitation assay to show that, like beta 1-syntrophin, both beta 2- and alpha 1-syntrophin interact with peptides encoding the syntrophin-binding re... | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_05332","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DMD and LAMA1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Finally, we used in vitro translated proteins ... | |
medium_convergence_05334 | CDAN1 and MMS22L both interact with a shared protein partner. Evidence indicates that Codanin-1 (CDAN1) is part of a cytosolic Asf1-H3.1-H4-Importin-4 complex and binds directly to Asf1 via a conserved B-domain, implying a mutually exclusive interaction with the chaperones CAF-1 and HIRA. Which gene encodes this shared... | Histone chaperone ASF1B | Medium | convergence | {"qa_id":"medium_convergence_05334","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDAN1 and MMS22L both interact with a shared protein partner. Evidence indicates that Codanin-1 (CDAN1) is part of a cytosolic Asf1-H3.1-H4-Importin-4 comple... | |
medium_convergence_05335 | Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.307 and an adjusted p-value of 0.002873. Which protein is encoded by this gene? | Early activation antigen CD69 | Medium | convergence | {"qa_id":"medium_convergence_05335","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114... | |
medium_convergence_05336 | NBN and RAD51 both interact with a shared protein partner. Experimental evidence indicates that this shared partner and its associated protein, RAD51L3, interact with RAD51 in a two-hybrid system. Which protein is encoded by the gene corresponding to this shared partner? | DNA repair protein XRCC2 | Medium | convergence | {"qa_id":"medium_convergence_05336","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NBN and RAD51 both interact with a shared protein partner. Experimental evidence indicates that this shared partner and its associated protein, RAD51L3, inte... | |
medium_convergence_05337 | Both the androgen receptor (AR) and SMAD4 share interaction partners. One such shared partner is described in evidence stating: 'Here we identify a novel PIAS-like protein, [shared partner], as an AR-interacting protein.' Which protein is encoded by this shared interaction partner? | Zinc finger MIZ domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05337","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the androgen receptor (AR) and SMAD4 share interaction partners. One such shared partner is described in evidence stating: 'Here we identify a novel PIA... | |
medium_convergence_05338 | RACK1 and ESR1 share common interaction partners. One such shared partner is known to interact with RACK1 in the cytoplasm, where RACK1 functions as a receptor for activated protein kinase C (PKC). Which protein is encoded by this shared interaction partner? | Eukaryotic translation initiation factor 6 | Medium | convergence | {"qa_id":"medium_convergence_05338","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 and ESR1 share common interaction partners. One such shared partner is known to interact with RACK1 in the cytoplasm, where RACK1 functions as a recept... | |
medium_convergence_05339 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (study GSE106475) reports a log2 fold change of approximately 1.023 and an adjusted p-value of 0.01154. Which cellular component is this gene located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_05339","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (study GSE106475) reports a log2 fold... | |
medium_convergence_05340 | BMP2 and BMP4 are both involved in a shared biological process. Evidence indicates that in vitro studies confirmed BMP2 and BMP4 induce phosphorylation of Smad1/5, as well as migration and proliferation of pulmonary artery endothelial cells (PAECs). Which anatomical structure is the result of the development associated... | lung vasculature | Medium | convergence | {"qa_id":"medium_convergence_05340","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP2 and BMP4 are both involved in a shared biological process. Evidence indicates that in vitro studies confirmed BMP2 and BMP4 induce phosphorylation of Sm... | |
medium_convergence_05342 | Human polyomavirus 1 and Measles morbillivirus both upregulate a specific gene in renal epithelial cells. Experimental data from study GSE135833 indicates that this shared target exhibits a log2 fold change of approximately 3.80 and an adjusted p-value of 0.0104. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05342","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Measles morbillivirus both upregulate a specific gene in renal epithelial cells. Experimental data from study GSE135833 indicates th... | |
medium_convergence_05343 | HSPA1B and HSP90AA1 both interact with a shared protein. Experimental evidence indicates that under basal conditions, this shared protein co-immunoprecipitates with HSP90. Which protein is encoded by this shared entity? | Tyrosine-protein kinase receptor UFO | Medium | convergence | {"qa_id":"medium_convergence_05343","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA1B and HSP90AA1 both interact with a shared protein. Experimental evidence indicates that under basal conditions, this shared protein co-immunoprecipitat... | |
medium_convergence_05344 | Both YWHAQ and YWHAE interact with a common protein partner. Experimental evidence for this partner states: 'We demonstrate direct and robust interaction between h[partner] and six of the seven 14-3-3 isoforms in vitro, suggestive of a novel protein interaction network between DNA repair and cell cycle control.' Which ... | hypersensitivity reaction disease | Medium | convergence | {"qa_id":"medium_convergence_05344","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both YWHAQ and YWHAE interact with a common protein partner. Experimental evidence for this partner states: 'We demonstrate direct and robust interaction bet... | |
medium_convergence_05345 | Eptifibatide and Ibritumomab tiuxetan both interact with a specific drug. Clinical evidence regarding this shared drug describes a phase II dose escalation, randomized, double-blind study evaluating its safety and efficacy versus placebo in patients receiving thrombolytic therapy with it for acute myocardial infarction... | pulmonary embolism | Medium | convergence | {"qa_id":"medium_convergence_05345","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Eptifibatide and Ibritumomab tiuxetan both interact with a specific drug. Clinical evidence regarding this shared drug describes a phase II dose escalation, ... | |
medium_convergence_05348 | HUWE1 and GSK3B both interact with a shared protein. Evidence regarding this shared protein states: 'Of note, the BH3 domain of LASU1 interacted with a Bcl-2 family member but not with Bcl-2 or Bcl-Xl.' Which protein is encoded by the gene corresponding to this shared entity? | Induced myeloid leukemia cell differentiation protein Mcl-1 | Medium | convergence | {"qa_id":"medium_convergence_05348","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and GSK3B both interact with a shared protein. Evidence regarding this shared protein states: 'Of note, the BH3 domain of LASU1 interacted with a Bcl-2... | |
medium_convergence_05349 | WDR5 and EZH2 both interact with a shared protein. Evidence indicates that this shared protein co-localizes with WDR5 and interacts with it, leading to the repression of WDR5's ubiquitination and degradation. Which protein is encoded by the gene corresponding to this shared entity? | Ubiquitin carboxyl-terminal hydrolase 44 | Medium | convergence | {"qa_id":"medium_convergence_05349","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WDR5 and EZH2 both interact with a shared protein. Evidence indicates that this shared protein co-localizes with WDR5 and interacts with it, leading to the r... | |
medium_convergence_05350 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of -1.772 and an adjusted p-value of 0.04329. Which protein is encoded by this gene? | Poliovirus receptor | Medium | convergence | {"qa_id":"medium_convergence_05350","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) ind... | |
medium_convergence_05351 | NRAS and RAC1 share multiple interacting partners. One such shared partner is distinguished by evidence showing that a specific guanine nucleotide exchange factor specifically interacts with both dominant negative and nucleotide-free forms of H-Ras and this partner, but not with their corresponding oncogenic forms. Whi... | T-cell adult acute lymphocytic leukemia | Medium | convergence | {"qa_id":"medium_convergence_05351","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NRAS and RAC1 share multiple interacting partners. One such shared partner is distinguished by evidence showing that a specific guanine nucleotide exchange f... | |
medium_convergence_05352 | NEDD4 and TSG101 both interact with a shared protein. Evidence indicates that for one such shared partner, budding is driven by a specific interaction with a tetrapeptide PSAP motif of an accessory protein, arrestin domain-containing protein 1, which is localized to the plasma membrane through its arrestin domain. Whic... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_05352","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4 and TSG101 both interact with a shared protein. Evidence indicates that for one such shared partner, budding is driven by a specific interaction with a... | |
medium_convergence_05353 | Both KIT and KITLG share a binding partner that is a cytoplasmic, src-related kinase. Evidence indicates this kinase physically associates with c-KIT through a region containing a proline-rich motif located amino-terminal to the SH3 domain. Which gene interacts with this specific kinase? | SOCS1 | Medium | convergence | {"qa_id":"medium_convergence_05353","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both KIT and KITLG share a binding partner that is a cytoplasmic, src-related kinase. Evidence indicates this kinase physically associates with c-KIT through... | |
medium_convergence_05354 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of 1.254 and an adjusted p-value of 0.03989. Which cell type is this gene enriched in? | gamma-delta T cell | Medium | convergence | {"qa_id":"medium_convergence_05354","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this ge... | |
medium_convergence_05355 | SIN3A and ZBTB16 both interact with a shared protein entity. Experimental evidence regarding a mutant of this entity indicates that it retains the ability to homodimerize and bind to N-CoR, but exhibits only weak binding to mSin3A. Which protein is encoded by this shared entity? | Protein CBFA2T1 | Medium | convergence | {"qa_id":"medium_convergence_05355","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and ZBTB16 both interact with a shared protein entity. Experimental evidence regarding a mutant of this entity indicates that it retains the ability to... | |
medium_convergence_05356 | EP300 and ESR1 share multiple interacting partners. One such shared partner is a nuclear protein that is acetylated at Lysine 160 by the acetyltransferase p300/CREB binding protein (CBP) via direct interaction, a modification that stimulates the acetylation and catalytic activity of p300/CBP. Which gene does this speci... | HTT | Medium | convergence | {"qa_id":"medium_convergence_05356","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and ESR1 share multiple interacting partners. One such shared partner is a nuclear protein that is acetylated at Lysine 160 by the acetyltransferase p3... | |
medium_convergence_05357 | Dengue virus and Enterovirus A both upregulate a specific host gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately 3.199 and an adjusted p-value of 0.02197. Which protein is encoded by this gene? | Palmitoyltransferase ZDHHC23 | Medium | convergence | {"qa_id":"medium_convergence_05357","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific host gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2... | |
medium_convergence_05358 | BMP7 and BMP15 both interact with a specific transmembrane serine/threonine kinase. Evidence indicates this kinase binds BMP-7 (and BMP-2) in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which disease is associated with this kinase as a biomarker? | anemia due to chronic disorder | Medium | convergence | {"qa_id":"medium_convergence_05358","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP7 and BMP15 both interact with a specific transmembrane serine/threonine kinase. Evidence indicates this kinase binds BMP-7 (and BMP-2) in association wit... | |
medium_convergence_05359 | ERLIN2 and TP53 share multiple interacting partners. One such shared partner is characterized by evidence stating that Co-immunoprecipitation studies indicate it bridges SPFH2 to gp78 in ER membranes. Which protein is encoded by this specific shared partner? | Transmembrane and ubiquitin-like domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05359","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERLIN2 and TP53 share multiple interacting partners. One such shared partner is characterized by evidence stating that Co-immunoprecipitation studies indicat... | |
medium_convergence_05360 | ATP5F1B and PRKN both interact with a shared protein. Evidence indicates that in cellular models, parkin ubiquitinates this shared protein, thereby regulating its levels via the proteasome system, whereas clinically relevant parkin mutants fail to do so. Which protein is encoded by the gene corresponding to this shared... | Tyrosine-protein phosphatase non-receptor type 5 | Medium | convergence | {"qa_id":"medium_convergence_05360","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATP5F1B and PRKN both interact with a shared protein. Evidence indicates that in cellular models, parkin ubiquitinates this shared protein, thereby regulatin... | |
medium_convergence_05361 | COG4 and ANK1 each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'Our results suggest that COG4 serves as a core component of the complex by interacting directly with COG1, COG2, this shared protein, and COG7.' Which protein is connected to this shared protein thro... | Conserved oligomeric Golgi complex subunit 5 | Medium | convergence | {"qa_id":"medium_convergence_05361","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COG4 and ANK1 each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'Our results suggest that COG4 serves... | |
medium_convergence_05362 | COPS5 and COPS7B both interact with a shared protein partner. Evidence regarding this partner states: 'Purification of the human CSN complex from a stable 293 cell line expressing N-terminal HBTH-tagged CSN5 subunit was achieved by high-affinity streptavidin binding with TEV cleavage elution.' Which protein is encoded ... | COP9 signalosome complex subunit 8 | Medium | convergence | {"qa_id":"medium_convergence_05362","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and COPS7B both interact with a shared protein partner. Evidence regarding this partner states: 'Purification of the human CSN complex from a stable 29... | |
medium_convergence_05363 | VPS25 and MVB12A both interact with a common protein partner. Evidence regarding this partner states: 'The complex has three lobes and contains one copy each of VPS22 and the shared protein and two copies of VPS25.' Which protein is encoded by the gene corresponding to this shared protein? | Vacuolar protein-sorting-associated protein 36 | Medium | convergence | {"qa_id":"medium_convergence_05363","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS25 and MVB12A both interact with a common protein partner. Evidence regarding this partner states: 'The complex has three lobes and contains one copy each... | |
medium_convergence_05364 | CSNK2A1 and ECT2 both interact with a common protein. Experimental evidence indicates that CK2 is recruited to this protein following ionizing radiation and phosphorylates conserved residues Ser 154, 649, 651, and 683 within its N- and C-terminal domains in mouse models. What protein is encoded by the gene correspondin... | NAD-dependent protein deacetylase sirtuin-1 | Medium | convergence | {"qa_id":"medium_convergence_05364","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and ECT2 both interact with a common protein. Experimental evidence indicates that CK2 is recruited to this protein following ionizing radiation and ... | |
medium_convergence_05366 | CCNH and CTR9 both interact with a shared protein complex component. Evidence regarding this component states: 'Using functionally tagged forms of the Paf1 complex factors, we have determined that, except for the more loosely associated Rtf1, the remaining components stay stably associated with one another in an RNase-... | RNA polymerase-associated protein LEO1 | Medium | convergence | {"qa_id":"medium_convergence_05366","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCNH and CTR9 both interact with a shared protein complex component. Evidence regarding this component states: 'Using functionally tagged forms of the Paf1 c... | |
medium_convergence_05367 | CHUK and CD40 share multiple interacting partners. One such partner is described by evidence stating that a MAP3K family member interacts with and stimulates the activities of both IKKalpha and IKKbeta in transfected HeLa and COS-1 cells and directly phosphorylates the IKKs in vitro. Which protein is connected to this ... | Mitogen-activated protein kinase kinase kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_05367","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and CD40 share multiple interacting partners. One such partner is described by evidence stating that a MAP3K family member interacts with and stimulates... | |
medium_convergence_05368 | NMU and GNA11 both interact with a shared protein target. Evidence regarding this target states: 'The receptors characterized in this report are activated by neuromedin U at nanomolar potency in heterologous expression systems and bind radiolabeled neuromedin U with high affinity.' Which protein is encoded by the gene ... | Neuromedin-U receptor 1 | Medium | convergence | {"qa_id":"medium_convergence_05368","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NMU and GNA11 both interact with a shared protein target. Evidence regarding this target states: 'The receptors characterized in this report are activated by... | |
medium_convergence_05369 | RIPK3 and RIPK1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In human HT29 cells, this entity associated with RIPK1 and RIPK3 as well as ubiquitin ligases cIAP1 and LUBAC.' Which protein is connected to that entity through the 'encodes' relation? | Z-DNA-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05369","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RIPK3 and RIPK1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In human HT29 cells, this entity associated ... | |
medium_convergence_05370 | CTNNB1 and CDH1 share multiple binding partners. One such shared partner is described as a recently discovered calmodulin-binding protein that binds stoichiometrically to beta-catenin and regulates the association of beta-catenin with the cell-cell adhesion complex. Which disease is associated with this specific protei... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05370","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and CDH1 share multiple binding partners. One such shared partner is described as a recently discovered calmodulin-binding protein that binds stoichio... | |
medium_convergence_05371 | WDR5 and NFIC share common interaction partners. One such shared partner is implicated in a study where BPA exposure was shown to enhance its interaction with WDR5, promote the recruitment of the resulting complex to the ERβ promoter and Exon 1, and inhibit DNA methylation of CpG islands. Which protein is encoded by th... | Methylcytosine dioxygenase TET2 | Medium | convergence | {"qa_id":"medium_convergence_05371","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WDR5 and NFIC share common interaction partners. One such shared partner is implicated in a study where BPA exposure was shown to enhance its interaction wit... | |
medium_convergence_05372 | NCOA1 and NCOR1 both interact with a specific thyroid hormone receptor gene. Evidence regarding this interaction states: 'In electrophoretic mobility shift assays, wild-type [thyroid hormone receptor beta isoform 1] interacted with N-CoR in the absence of ligand, whereas T3 caused dissociation of the [thyroid hormone r... | Thyroid hormone receptor beta | Medium | convergence | {"qa_id":"medium_convergence_05372","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCOA1 and NCOR1 both interact with a specific thyroid hormone receptor gene. Evidence regarding this interaction states: 'In electrophoretic mobility shift a... | |
medium_convergence_05373 | MARVELD2 and MARVELD3 are both involved in multiple shared biological processes. One of these shared processes is linked to a specific entity described as a novel tight junction protein containing a conserved four-transmembrane MARVEL domain, similar to occludin and tricellulin. Which biological process is connected to... | tight junction assembly | Medium | convergence | {"qa_id":"medium_convergence_05373","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MARVELD2 and MARVELD3 are both involved in multiple shared biological processes. One of these shared processes is linked to a specific entity described as a ... | |
medium_convergence_05374 | Vaccinia virus and Zaire ebolavirus both downregulate a specific host gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of -4.308 and an adjusted p-value of 0.008255. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05374","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Zaire ebolavirus both downregulate a specific host gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE... | |
medium_convergence_05375 | CHUK and AKT1 share multiple interacting partners. One such partner is described in evidence stating: 'Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling an... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_05375","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and AKT1 share multiple interacting partners. One such partner is described in evidence stating: 'Here we show that lithium, a pharmacological agent use... | |
medium_convergence_05376 | EHMT2 and PARP1 both interact with a shared gene product. Contextual evidence indicates that this shared entity associates in vivo with SET/I2PP2A and G9a, but shows no detectable association with HDAC1 or HATs. Which protein is encoded by this shared gene? | Barrier-to-autointegration factor | Medium | convergence | {"qa_id":"medium_convergence_05376","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and PARP1 both interact with a shared gene product. Contextual evidence indicates that this shared entity associates in vivo with SET/I2PP2A and G9a, b... | |
medium_convergence_05377 | GRB2 and GAB2 both interact with a specific protein target. Experimental evidence indicates that the binding of GRB2 to this target is strictly dependent on intact phosphorylation sites Y703 and Y936. Which protein is encoded by the gene corresponding to this target? | Mast/stem cell growth factor receptor Kit | Medium | convergence | {"qa_id":"medium_convergence_05377","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and GAB2 both interact with a specific protein target. Experimental evidence indicates that the binding of GRB2 to this target is strictly dependent on ... | |
medium_convergence_05378 | FOS and JUNB both interact with a specific transcription factor. Evidence indicates that this factor forms dimers with diverse Jun and Fos family proteins, which are stably associated in vivo with ERK-related proteins. Which cell type is this transcription factor enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05378","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOS and JUNB both interact with a specific transcription factor. Evidence indicates that this factor forms dimers with diverse Jun and Fos family proteins, w... | |
medium_convergence_05380 | FAAP20 and FANCE each interact with more than one shared gene product. Evidence concerning one of these shared entities states: 'The human protein reportedly functions as a molecular adaptor within the FA nuclear complex, bridging between the subcomplexes A:G and C:E.' Which gene is connected to that entity through an ... | GINS2 | Medium | convergence | {"qa_id":"medium_convergence_05380","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAAP20 and FANCE each interact with more than one shared gene product. Evidence concerning one of these shared entities states: 'The human protein reportedly... | |
medium_convergence_05381 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.85 and an adjusted p-value of approximately 0.012. Which protein is encoded by this gene? | Zinc finger and BTB domain-containing protein 10 | Medium | convergence | {"qa_id":"medium_convergence_05381","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) ... | |
medium_convergence_05383 | Hepacivirus C and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in peripheral blood mononuclear cells shows a log2 fold change of -2.287 and an adjusted p-value of 0.007515. Which protein is encoded by this gene? | Rhophilin-1 | Medium | convergence | {"qa_id":"medium_convergence_05383","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in peripheral blood mononuclear cells shows a log2 fold cha... | |
medium_convergence_05384 | Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific host gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.084 and an adjusted p-value of 0.001163. Which protein is encoded by this gene? | Dehydrogenase/reductase SDR family member 6 | Medium | convergence | {"qa_id":"medium_convergence_05384","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific host gene. Experimental data for this gene in a monocytic ... | |
medium_convergence_05385 | EXOSC2 and NCBP1 share multiple binding partners. One of these shared partners is a protein that binds the cap-binding complex (CBC), which is universally present on capped RNAs, and also associates with the nuclear exosome targeting (NEXT) complex, thereby linking to RNA decay. Which biological process is this specifi... | RNA destabilization | Medium | convergence | {"qa_id":"medium_convergence_05385","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EXOSC2 and NCBP1 share multiple binding partners. One of these shared partners is a protein that binds the cap-binding complex (CBC), which is universally pr... | |
medium_convergence_05386 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that this gene exhibits a log2 fold change of approximately 1.445 and an adjusted p-value of 0.0309. Which biol... | Golgi organization | Medium | convergence | {"qa_id":"medium_convergence_05386","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from ... | |
medium_convergence_05387 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately 3.99 and an adjusted p-value of 0.03813. In which cell type is this gene enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05387","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for t... | |
medium_convergence_05388 | TOPBP1 and CRY2 share common interaction partners. One such partner is specifically identified in experimental evidence stating: 'We found that the tetratricopeptide repeat protein 1, Tpr1, and the protein serine/threonine phosphatase 5 that contains the TPR motif specifically interacted with hCRY2.' Which disease is a... | ductal breast carcinoma in situ | Medium | convergence | {"qa_id":"medium_convergence_05388","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and CRY2 share common interaction partners. One such partner is specifically identified in experimental evidence stating: 'We found that the tetratric... | |
medium_convergence_05389 | Hepacivirus C and Dengue virus both upregulate a specific gene. Experimental data for this gene in peripheral blood mononuclear cells from study GSE119117 reports a log2 fold change of approximately 1.068 and an adjusted p-value of 0.00182. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_05389","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both upregulate a specific gene. Experimental data for this gene in peripheral blood mononuclear cells from study GSE119117 re... | |
medium_convergence_05390 | AGR2 and CFTR share common interacting partners. One such shared partner forms a stable complex with Reptin in human cell lysates, validating Reptin as a binding protein for this entity. Which disease is associated with this specific shared partner via a biomarker relationship? | Fanconi anemia | Medium | convergence | {"qa_id":"medium_convergence_05390","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AGR2 and CFTR share common interacting partners. One such shared partner forms a stable complex with Reptin in human cell lysates, validating Reptin as a bin... | |
medium_convergence_05391 | PLK1 and MAPK8 both interact with a shared gene product. Experimental evidence indicates that JNK1 (encoded by MAPK8), but not JNK2, interacts with and phosphorylates this shared entity ex vivo and in vitro. Which disease is associated with this shared entity via a biomarker relationship? | myelodysplastic syndrome | Medium | convergence | {"qa_id":"medium_convergence_05391","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PLK1 and MAPK8 both interact with a shared gene product. Experimental evidence indicates that JNK1 (encoded by MAPK8), but not JNK2, interacts with and phosp... | |
medium_convergence_05393 | ALDH3A2 and BAG6 both interact with a shared protein. Evidence regarding this shared protein states: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified as novel interaction partners while interaction with Hsc70 was confirmed.' Which disease is associated with this shared protein? | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_05393","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALDH3A2 and BAG6 both interact with a shared protein. Evidence regarding this shared protein states: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified a... | |
medium_convergence_05394 | ECT2 and GRB2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'By the use of an in vivo genetic approach and through in vitro experiments, we furnish evidence that both Grb2 and Grb3-3 interact with hnRNP C proteins.' Which protein is encoded by this shared entity? | Heterogeneous nuclear ribonucleoproteins C1/C2 | Medium | convergence | {"qa_id":"medium_convergence_05394","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ECT2 and GRB2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'By the use of an in vivo genetic approach and thro... | |
medium_convergence_05395 | CBX1 and CBX3 both interact with a specific protein. Evidence indicates that this protein surprisingly forms a stable complex with the centromeric heterochromatin components HP1alpha and HP1gamma. Which protein is encoded by the gene corresponding to this interacting entity? | Protein MIS12 homolog | Medium | convergence | {"qa_id":"medium_convergence_05395","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX1 and CBX3 both interact with a specific protein. Evidence indicates that this protein surprisingly forms a stable complex with the centromeric heterochro... | |
medium_convergence_05396 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. Experimental data for this gene shows a log2 fold change of 2.339 and an adjusted p-value of 0.02477. Which protein is encoded by this gene? | GTPase RhebL1 | Medium | convergence | {"qa_id":"medium_convergence_05396","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. Experimental data for this gene shows a log2 fold change of 2.339 and ... | |
medium_convergence_05397 | LTA and TNF both interact with a specific shared protein. Evidence indicates that this shared protein, along with LT, binds with higher affinity to the p80 receptor than to the p60 receptor. Which protein is encoded by the gene corresponding to this shared entity? | Tumor necrosis factor receptor superfamily member 1B | Medium | convergence | {"qa_id":"medium_convergence_05397","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LTA and TNF both interact with a specific shared protein. Evidence indicates that this shared protein, along with LT, binds with higher affinity to the p80 r... | |
medium_convergence_05398 | HSP90AA1 and HSP90AB1 both interact with a specific shared protein. Evidence indicates that functional inhibition of Hsp90 by the anti-tumor agent geldanamycin (GA) efficiently disrupts its interaction with this shared protein, resulting in its degradation and subsequent blockage of p100 processing. Which protein is en... | Mitogen-activated protein kinase kinase kinase 14 | Medium | convergence | {"qa_id":"medium_convergence_05398","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and HSP90AB1 both interact with a specific shared protein. Evidence indicates that functional inhibition of Hsp90 by the anti-tumor agent geldanamyc... | |
medium_convergence_05399 | CSNK1E and APC both interact with a shared protein partner. Experimental evidence indicates that this partner was co-precipitated with either GSK3beta or beta-catenin in both cell lines using immunoprecipitation. Which protein is encoded by this shared partner? | Glycogen synthase kinase-3 beta | Medium | convergence | {"qa_id":"medium_convergence_05399","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1E and APC both interact with a shared protein partner. Experimental evidence indicates that this partner was co-precipitated with either GSK3beta or bet... | |
medium_convergence_05400 | COMMD1 and CUL3 share multiple binding partners. One such partner is identified in the literature as an important protein adaptor linking SK1 to the cullin 3 ubiquitin ligase complex, specifically identified via yeast two-hybrid screening as a kelch-like protein. Which cellular component is this entity located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_05400","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL3 share multiple binding partners. One such partner is identified in the literature as an important protein adaptor linking SK1 to the cullin 3... | |
medium_convergence_05401 | EP300 and HDAC1 both interact with a shared protein entity. Evidence indicates that this entity is stably associated with RNA polymerase II and the coactivator p300 on the endogenous MDR1 promoter. Which protein is encoded by the gene corresponding to this shared entity? | DNA repair nuclease/redox regulator APEX1 | Medium | convergence | {"qa_id":"medium_convergence_05401","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and HDAC1 both interact with a shared protein entity. Evidence indicates that this entity is stably associated with RNA polymerase II and the coactivat... | |
medium_convergence_05402 | Fibrinogen beta chain (FGB) and Interleukin-1 receptor type 1 (IL1R1) both interact with a common protein. Experimental evidence indicates that when human embryonic kidney cells (HEK293) over-expressing IL-1RI or HeLa cells are exposed to IL-1, this shared protein rapidly associates with the IL-1RI complex and undergoe... | Interleukin-1 receptor-associated kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_05402","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Fibrinogen beta chain (FGB) and Interleukin-1 receptor type 1 (IL1R1) both interact with a common protein. Experimental evidence indicates that when human em... | |
medium_convergence_05403 | HSP90AA1 and MYC share multiple interacting partners. One such partner is characterized by evidence stating it associates with HSP90 and CRAF in cells via its N-terminal DOC domain, a domain that is mutationally disrupted in tumor cells with activated MAP kinase signaling. Which protein is encoded by this specific inte... | E3 ubiquitin-protein ligase HECTD3 | Medium | convergence | {"qa_id":"medium_convergence_05403","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and MYC share multiple interacting partners. One such partner is characterized by evidence stating it associates with HSP90 and CRAF in cells via it... | |
medium_convergence_05404 | HDAC6 and COPS5 both interact with a specific shared protein. Evidence indicates that Jab1/CSN5, a component of the COP9 signalosome complex, associates constitutively with this shared protein. Which protein is encoded by the gene corresponding to this shared entity? | SMAD family member 7 | Medium | convergence | {"qa_id":"medium_convergence_05404","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and COPS5 both interact with a specific shared protein. Evidence indicates that Jab1/CSN5, a component of the COP9 signalosome complex, associates cons... | |
medium_convergence_05405 | CTBP1 and KDM1A share multiple interacting partners. One such shared partner is described in a study stating: 'Here we show that this protein forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtBP1 and regulates Wnt/β-catenin-dependent gene expression.' Which protein is encoded by this shared inte... | Zinc finger protein Gfi-1b | Medium | convergence | {"qa_id":"medium_convergence_05405","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and KDM1A share multiple interacting partners. One such shared partner is described in a study stating: 'Here we show that this protein forms complexes... | |
medium_convergence_05406 | CREBBP and NCOA6 both interact with a specific transcription factor. Experimental evidence indicates that this transcription factor interacts with CBP (CREBBP) in a ligand-independent manner, specifically involving the middle portion (amino acids 119-375) of the transcription factor and two distinct regions (amino acid... | Hepatocyte nuclear factor 4-alpha | Medium | convergence | {"qa_id":"medium_convergence_05406","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and NCOA6 both interact with a specific transcription factor. Experimental evidence indicates that this transcription factor interacts with CBP (CREBB... | |
medium_convergence_05407 | RNF20 and HIST1H2BC share interaction partners. One such shared partner forms a heterodimer with RNF20, and evidence indicates that this heterodimer functions as an E3 ubiquitin ligase whose activity relies on recruitment to DNA double-strand break sites and ATM-dependent phosphorylation. Which protein is encoded by th... | E3 ubiquitin-protein ligase BRE1B | Medium | convergence | {"qa_id":"medium_convergence_05407","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RNF20 and HIST1H2BC share interaction partners. One such shared partner forms a heterodimer with RNF20, and evidence indicates that this heterodimer function... | |
medium_convergence_05408 | Aldesleukin and Omeprazole both interact with a specific drug. Clinical evidence regarding this drug notes that five cases of adverse events were caused by interactions between the drug and other antiepileptic drugs, etravirine-based antiretroviral therapy, the drug itself, or meropenem. What disease is this drug indic... | epilepsy | Medium | convergence | {"qa_id":"medium_convergence_05408","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Aldesleukin and Omeprazole both interact with a specific drug. Clinical evidence regarding this drug notes that five cases of adverse events were caused by i... | |
medium_convergence_05409 | Both Measles morbillivirus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately 1.516 and an adjusted p-value of 0.03582. In which cellular component is this gene product located? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_05409","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold c... | |
medium_convergence_05410 | LAMTOR4 and ATG13 both interact with a specific protein. Evidence regarding this protein states: 'This phosphorylation inhibited the kinase activity of this protein, preventing it from binding to the downstream effector ATG13, and reduced autophagy in microglia.' Which protein is encoded by the gene corresponding to th... | Serine/threonine-protein kinase ULK1 | Medium | convergence | {"qa_id":"medium_convergence_05410","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR4 and ATG13 both interact with a specific protein. Evidence regarding this protein states: 'This phosphorylation inhibited the kinase activity of this ... | |
medium_convergence_05411 | CCL3 and CCL5 both interact with a specific G protein-coupled receptor. Evidence indicates that this receptor, cloned from human eosinophils, binds eotaxin, MCP-3, and RANTES with dissociation constants (Kd) of 0.1, 2.7, and 3.1 nM, respectively. Which disease is associated with this receptor as a biomarker? | pulmonary fibrosis | Medium | convergence | {"qa_id":"medium_convergence_05411","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCL3 and CCL5 both interact with a specific G protein-coupled receptor. Evidence indicates that this receptor, cloned from human eosinophils, binds eotaxin, ... | |
medium_convergence_05412 | BRD4 and SIRT6 share multiple interaction partners. One such shared partner is reported to interact with the anaphase-promoting complex/cyclosome (APC/C) and serves as its coactivator. Which disease is associated with this specific shared partner via a biomarker relationship? | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05412","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and SIRT6 share multiple interaction partners. One such shared partner is reported to interact with the anaphase-promoting complex/cyclosome (APC/C) and... | |
medium_convergence_05413 | Both Hepacivirus C and Zaire ebolavirus are known to upregulate a specific shared gene. Experimental evidence for this gene reports a log2 fold change of 2.383 and an adjusted p-value of 0.02388. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_05413","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Zaire ebolavirus are known to upregulate a specific shared gene. Experimental evidence for this gene reports a log2 fold change of 2.3... | |
medium_convergence_05414 | The canal of Schlemm and the conjunctival vein share a common anatomical classification. Evidence regarding one of these shared entities describes it as 'The vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation.' Which broader anatomical cat... | blood vessel | Medium | convergence | {"qa_id":"medium_convergence_05414","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The canal of Schlemm and the conjunctival vein share a common anatomical classification. Evidence regarding one of these shared entities describes it as 'The... | |
medium_convergence_05415 | MYC and PPP1CA each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Further characterization of the PP1-associated proteins identified a stable multimeric complex composed of regulatory subunits [Gene:PPP1R10], Tox4, and Wdr82 and a PP1 catalytic subunit (denoted as the ... | Serine/threonine-protein phosphatase 1 regulatory subunit 10 | Medium | convergence | {"qa_id":"medium_convergence_05415","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and PPP1CA each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Further characterization of the PP1-asso... | |
medium_convergence_05416 | Both West Nile virus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in monocyte-derived dendritic cells (from study GSE136342) reports a log2 fold change of approximately 1.067 and an adjusted p-value of 0.04715. Which cellular component is this gene l... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_05416","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in monocyte-derived d... | |
medium_convergence_05417 | BMI1 and CBX4 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Using tandem affinity purification, we find that CBX7 and this shared protein, two Polycomb (Pc) homologs that repress INK4a, both participate in PRC1-like complexes with at least two Posterior sex combs (Psc) pr... | Chromobox protein homolog 8 | Medium | convergence | {"qa_id":"medium_convergence_05417","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMI1 and CBX4 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Using tandem affinity purification, we find that ... | |
medium_convergence_05418 | Both the androgen receptor (AR) and the parkin protein (PRKN) interact with a specific shared gene product. Experimental evidence indicates that this shared entity is physically associated with a proteasome subunit and TBPIP in vitro and in LNCaP cells. Which disease is linked to this entity via a biomarker relationshi... | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_05418","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the androgen receptor (AR) and the parkin protein (PRKN) interact with a specific shared gene product. Experimental evidence indicates that this shared ... | |
medium_convergence_05419 | GDF2 and BMP4 both interact with a specific receptor. Experimental evidence indicates that in transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7, and less efficiently BMP-4, bound to this receptor. Which protein is encoded by the gene corresponding to this receptor? | Bone morphogenetic protein receptor type-2 | Medium | convergence | {"qa_id":"medium_convergence_05419","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GDF2 and BMP4 both interact with a specific receptor. Experimental evidence indicates that in transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7, and l... | |
medium_convergence_05420 | Both Influenza A virus and Rhinovirus A are known to downregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line shows a log2 fold change of approximately -1.28 and an adjusted p-value of 0.0079. In which cellular component is this gene product located? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_05420","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Rhinovirus A are known to downregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma ce... | |
medium_convergence_05421 | DNTT and DCLRE1C each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Here, we report that Artemis forms a complex with the 469 kDa DNA-dependent protein kinase (the protein encoded by PRKDC) in the absence of DNA.' Which protein is connected to that entity through th... | DNA-dependent protein kinase catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_05421","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNTT and DCLRE1C each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Here, we report that Artemis forms ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.