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medium_convergence_05422 | Both Dengue virus and Cardiovirus A are known to downregulate the expression of a specific gene. In a study using a hepatoma cell line (GSE110512), this gene was found to have a log2 fold change of -1.331 and an adjusted p-value of 0.007869. Which protein does this gene product interact with? | RAB7A | Medium | convergence | {"qa_id":"medium_convergence_05422","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Dengue virus and Cardiovirus A are known to downregulate the expression of a specific gene. In a study using a hepatoma cell line (GSE110512), this gene... | |
medium_convergence_05424 | COG4 and ANK3 each interact with more than one shared protein. Evidence concerning one shared entity states: 'Our results suggest that COG4 serves as a core component of the complex by interacting directly with COG1, COG2, COG5, and this entity.' Which molecular function is enabled by this entity? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05424","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COG4 and ANK3 each interact with more than one shared protein. Evidence concerning one shared entity states: 'Our results suggest that COG4 serves as a core ... | |
medium_convergence_05425 | MIR145 and MIR18A are both involved in more than one shared biological process. One such shared process is linked to evidence stating that 'miR-145 was found to regulate numerous genes involved in the EMT.' Which biological process is negatively regulated by this shared entity? | epithelial to mesenchymal transition | Medium | convergence | {"qa_id":"medium_convergence_05425","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIR145 and MIR18A are both involved in more than one shared biological process. One such shared process is linked to evidence stating that 'miR-145 was found... | |
medium_convergence_05426 | Human polyomavirus 1 and Zika virus both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of approximately 2.57 and an adjusted p-value of 0.0218. In which cell type is this gene reported to be enriched? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_05426","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Zika virus both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of approximately... | |
medium_convergence_05427 | Both LAMC2 and CDC42 interact with a specific protein kinase. Experimental evidence indicates that this kinase binds strongly to GTP-Cdc42 and weakly to GTP-Rac. Which protein is encoded by the gene corresponding to this kinase? | Serine/threonine-protein kinase PAK 6 | Medium | convergence | {"qa_id":"medium_convergence_05427","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both LAMC2 and CDC42 interact with a specific protein kinase. Experimental evidence indicates that this kinase binds strongly to GTP-Cdc42 and weakly to GTP-... | |
medium_convergence_05429 | ERCC4 and PCNA each interact with a shared protein. Evidence concerning one such shared entity states: 'The DNA polymerase processivity factor PCNA is monoubiquitinated and interacts with Polkappa in cells treated with the bulky adduct-forming genotoxin benzo[a]pyrene dihydrodiol epoxide (BPDE).' Which protein is encod... | DNA polymerase kappa | Medium | convergence | {"qa_id":"medium_convergence_05429","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC4 and PCNA each interact with a shared protein. Evidence concerning one such shared entity states: 'The DNA polymerase processivity factor PCNA is monoub... | |
medium_convergence_05430 | MYD88 and BGN share multiple binding partners. One shared partner is known to form homodimers and heterodimers with MyD88. Which protein is encoded by this shared partner? | Toll/interleukin-1 receptor domain-containing adapter protein | Medium | convergence | {"qa_id":"medium_convergence_05430","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYD88 and BGN share multiple binding partners. One shared partner is known to form homodimers and heterodimers with MyD88. Which protein is encoded by this s... | |
medium_convergence_05431 | CC2D2A and CEP135 both interact with a shared protein partner. Evidence for one of these partners indicates that the proteins can physically interact in vitro, as demonstrated by yeast two-hybrid and GST pull-down experiments. Which disease is associated with this specific protein partner through genomic alterations? | Leber congenital amaurosis 1 | Medium | convergence | {"qa_id":"medium_convergence_05431","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CC2D2A and CEP135 both interact with a shared protein partner. Evidence for one of these partners indicates that the proteins can physically interact in vitr... | |
medium_convergence_05432 | CHD4 and HDAC1 both interact with a shared protein. Experimental evidence from a yeast two-hybrid screen using this shared protein identified chromodomain helicase DNA-binding protein 4 (CHD4) as an interactor. Which cell type is enriched for this shared protein? | naive thymus-derived CD8-positive, alpha-beta T cell | Medium | convergence | {"qa_id":"medium_convergence_05432","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and HDAC1 both interact with a shared protein. Experimental evidence from a yeast two-hybrid screen using this shared protein identified chromodomain he... | |
medium_convergence_05433 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximately 1.71 and an adjusted p-value of 0.0089. In which cell type is this gene enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05433","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximate... | |
medium_convergence_05434 | COPS6 and COPS2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The immunoprecipitation assay verified that COP9 signalosome subunit 6 (CSN6) interacted with CULA4.' Which protein is encoded by the gene corresponding to that shared partner? | Cullin-4A | Medium | convergence | {"qa_id":"medium_convergence_05434","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS6 and COPS2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The immunoprecipitation assay v... | |
medium_convergence_05435 | CRKL and DOK1 both interact with a shared protein. Evidence regarding this shared protein indicates that its activation induces tyrosine phosphorylation of CRKL, and that CRKL coprecipitates with this protein through an interaction requiring the CRKL SH3 domains but not the SH2 domain. Which protein is encoded by the g... | Mast/stem cell growth factor receptor Kit | Medium | convergence | {"qa_id":"medium_convergence_05435","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRKL and DOK1 both interact with a shared protein. Evidence regarding this shared protein indicates that its activation induces tyrosine phosphorylation of C... | |
medium_convergence_05436 | RAB32 and GPR143 are both localized to more than one shared cellular component. Evidence indicates that silencing the BLOC-3 subunits Hps1 and Hps4 leads to the mislocalization of RAB32 (along with Rab38) and a reduction in pigmentation. Which cellular component, connected to the entity affected by this mislocalization... | chitosome | Medium | convergence | {"qa_id":"medium_convergence_05436","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAB32 and GPR143 are both localized to more than one shared cellular component. Evidence indicates that silencing the BLOC-3 subunits Hps1 and Hps4 leads to ... | |
medium_convergence_05437 | ACTR10 and COPB2 both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which cellular component is this shared partne... | Golgi membrane | Medium | convergence | {"qa_id":"medium_convergence_05437","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR10 and COPB2 both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatom... | |
medium_convergence_05438 | EZH2 and SUZ12 share a common interaction partner. Evidence indicates that this shared partner physically binds to EZH2, a component of the Polycomb repressive complex 2, which is required to repress CLU. Which protein is encoded by this shared interaction partner? | N-myc proto-oncogene protein | Medium | convergence | {"qa_id":"medium_convergence_05438","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and SUZ12 share a common interaction partner. Evidence indicates that this shared partner physically binds to EZH2, a component of the Polycomb repressi... | |
medium_convergence_05439 | COPB1 and CAPZA2 share a common interacting partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which protein is encoded by the gene corresponding to t... | Coatomer subunit beta' | Medium | convergence | {"qa_id":"medium_convergence_05439","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and CAPZA2 share a common interacting partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consis... | |
medium_convergence_05440 | YWHAB and YWHAE both interact with a specific ubiquitin-specific protease. Evidence indicates this protease is a regulatory component of the T cell antigen receptor (TCR) signalosome, interacting with the adaptor Gads and the regulatory molecule 14-3-3β. Which protein is encoded by this ubiquitin-specific protease gene... | Ubiquitin carboxyl-terminal hydrolase 8 | Medium | convergence | {"qa_id":"medium_convergence_05440","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAB and YWHAE both interact with a specific ubiquitin-specific protease. Evidence indicates this protease is a regulatory component of the T cell antigen r... | |
medium_convergence_05441 | FLT4 and KDR each interact with more than one shared ligand. Evidence concerning one shared entity reports: 'Here we present the crystal structure of a VEGF family member bound to the VEGFR-2 high-affinity-binding site, which consists of immunoglobulin homology domains D2 and D3.' Which protein is connected to that ent... | Vascular endothelial growth factor C | Medium | convergence | {"qa_id":"medium_convergence_05441","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FLT4 and KDR each interact with more than one shared ligand. Evidence concerning one shared entity reports: 'Here we present the crystal structure of a VEGF ... | |
medium_convergence_05442 | RC3H1 and ANLN both interact with a shared protein. Evidence indicates that Co-IP experiments confirmed a novel interaction between this shared protein and RC3H1. Which protein is encoded by this shared entity? | Ensconsin | Medium | convergence | {"qa_id":"medium_convergence_05442","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RC3H1 and ANLN both interact with a shared protein. Evidence indicates that Co-IP experiments confirmed a novel interaction between this shared protein and R... | |
medium_convergence_05443 | Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of -1.125 and an adjusted p-value of 0.004503. Which cellular component is this gene located in? | cytosol | Medium | convergence | {"qa_id":"medium_convergence_05443","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 ... | |
medium_convergence_05444 | Both Orthohepevirus A and Primate bocaparvovirus 1 are associated with the downregulation of a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of -1.616 and an adjusted p-value of 0.04951. Which protein is encoded by this gene? | Y+L amino acid transporter 1 | Medium | convergence | {"qa_id":"medium_convergence_05444","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Primate bocaparvovirus 1 are associated with the downregulation of a specific gene. Experimental data for this gene in hepatocytes ... | |
medium_convergence_05445 | EIF4A1 and EIF4A2 each interact with a shared protein partner. Experimental evidence involving Far-Western analysis and coimmunoprecipitation demonstrates that this shared partner directly interacts with eIF4E, eIF4A, and eIF3. Which protein is encoded by the gene corresponding to this shared partner? | Eukaryotic translation initiation factor 4 gamma 3 | Medium | convergence | {"qa_id":"medium_convergence_05445","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF4A1 and EIF4A2 each interact with a shared protein partner. Experimental evidence involving Far-Western analysis and coimmunoprecipitation demonstrates th... | |
medium_convergence_05446 | EIF3F and EIF3I each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein is encoded by the gene corresponding to that shared entity? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_05446","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3F and EIF3I each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Indeed, CIF-1 binds eIF-3.F and ... | |
medium_convergence_05448 | HDAC1 and BCL7B share multiple binding partners. One such shared partner is a component of a complex that contains HDAC1/2, RbAp46/48, and MBD3, but explicitly excludes Sin3 and Mi2. Which protein is encoded by the gene corresponding to this shared partner? | Metastasis-associated protein MTA1 | Medium | convergence | {"qa_id":"medium_convergence_05448","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and BCL7B share multiple binding partners. One such shared partner is a component of a complex that contains HDAC1/2, RbAp46/48, and MBD3, but explicit... | |
medium_convergence_05449 | GNAI1 and GNAQ both interact with a specific protein. Experimental evidence indicates that this protein interacts strongly with Galphai1, Galphai3, and Galphao, interacts weakly with Galphai2, and does not interact with Galphas. What molecular function is enabled by this protein? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05449","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI1 and GNAQ both interact with a specific protein. Experimental evidence indicates that this protein interacts strongly with Galphai1, Galphai3, and Galph... | |
medium_convergence_05450 | STUB1 and PIN1 both interact with a specific shared protein. Evidence indicates that CHIP binds to this shared protein, induces K6-linked polyubiquitylation of it, and suppresses DISC formation. Which protein is encoded by the gene corresponding to this shared entity? | FAS-associated death domain protein | Medium | convergence | {"qa_id":"medium_convergence_05450","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and PIN1 both interact with a specific shared protein. Evidence indicates that CHIP binds to this shared protein, induces K6-linked polyubiquitylation ... | |
medium_convergence_05451 | The vasculature of the liver and the vasculature of the heart share a common anatomical superclass. Evidence regarding one such shared entity describes it as 'An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart.' Which anatomical structure is this shared en... | trunk | Medium | convergence | {"qa_id":"medium_convergence_05451","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The vasculature of the liver and the vasculature of the heart share a common anatomical superclass. Evidence regarding one such shared entity describes it as... | |
medium_convergence_05452 | Vaccinia virus and Human alphaherpesvirus 1 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately -2.78 and an adjusted p-value of 0.013. Which protein is encoded by this gene? | Sestrin-3 | Medium | convergence | {"qa_id":"medium_convergence_05452","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human alphaherpesvirus 1 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) in... | |
medium_convergence_05453 | CHEK1 and KPNA2 both interact with a shared protein entity. Evidence regarding this entity states: 'Here we report the identification of the heterohexamic minichromosome maintenance (MCM) complex that interacts with Chk1 by mass spectrometry.' Which protein is connected to that entity through the 'encodes' relation? | DNA replication licensing factor MCM2 | Medium | convergence | {"qa_id":"medium_convergence_05453","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and KPNA2 both interact with a shared protein entity. Evidence regarding this entity states: 'Here we report the identification of the heterohexamic mi... | |
medium_convergence_05454 | CFTR and YWHAQ share multiple interacting partners. One such shared partner is characterized by evidence stating: 'We identified K18 Ser33 as an interphase phosphorylation site, which increases its phosphorylation during mitosis in cultured cells and regenerating liver, and as an in vitro cdc2 kinase phosphorylation si... | cholangiocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_05454","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFTR and YWHAQ share multiple interacting partners. One such shared partner is characterized by evidence stating: 'We identified K18 Ser33 as an interphase p... | |
medium_convergence_05455 | HERC5 and ISG15 both physically interact with a specific shared protein. Experimental evidence indicates that a physical association was found between the enzyme that activates ISG15 and this shared entity in vivo. Which protein is encoded by the gene corresponding to this shared entity? | Ubiquitin-like modifier-activating enzyme 7 | Medium | convergence | {"qa_id":"medium_convergence_05455","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HERC5 and ISG15 both physically interact with a specific shared protein. Experimental evidence indicates that a physical association was found between the en... | |
medium_convergence_05456 | NEDD4 and YWHAE both interact with a specific shared protein. Experimental evidence indicates that this shared protein, identified as CNrasGEF, possesses two PY motifs at its C-terminus that are responsible for binding to NEDD4 in vitro. Which protein is encoded by this shared entity? | Rap guanine nucleotide exchange factor 2 | Medium | convergence | {"qa_id":"medium_convergence_05456","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4 and YWHAE both interact with a specific shared protein. Experimental evidence indicates that this shared protein, identified as CNrasGEF, possesses two... | |
medium_convergence_05457 | SIRT1 and PRKDC both interact with a shared protein. Evidence regarding one such shared entity states: 'We identified DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Ku80, and Ku70 as [shared entity] associated factors.' Which protein is encoded by the gene corresponding to this shared entity? | Bile acid receptor | Medium | convergence | {"qa_id":"medium_convergence_05457","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIRT1 and PRKDC both interact with a shared protein. Evidence regarding one such shared entity states: 'We identified DNA-dependent protein kinase catalytic ... | |
medium_convergence_05458 | DNMT3A and AGO2 both interact with a specific histone variant gene. Experimental evidence indicates that Histone H3 (specifically excluding the H3K4me3 modification) disrupts the interaction between the ADD and CD domains of DNMT3A, induces a large conformational change in the ADD domain, and thereby releases the autoi... | Histone H3.3 | Medium | convergence | {"qa_id":"medium_convergence_05458","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT3A and AGO2 both interact with a specific histone variant gene. Experimental evidence indicates that Histone H3 (specifically excluding the H3K4me3 modif... | |
medium_convergence_05459 | IRF7 and IFIH1 each interact with more than one shared protein. Evidence concerning one shared entity reports that a mitochondrial antiviral-signaling adaptor contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infec... | Mitochondrial antiviral-signaling protein | Medium | convergence | {"qa_id":"medium_convergence_05459","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRF7 and IFIH1 each interact with more than one shared protein. Evidence concerning one shared entity reports that a mitochondrial antiviral-signaling adapto... | |
medium_convergence_05460 | GATA1 and ASH2L both interact with a specific protein. Evidence indicates that a minimized human RBBP5-ASH2L heterodimer serves as the structural unit interacting with and activating all MLL family histone methyltransferases. Which protein, connected to this shared entity via an 'encodes' relationship, is best supporte... | Histone-lysine N-methyltransferase 2C | Medium | convergence | {"qa_id":"medium_convergence_05460","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA1 and ASH2L both interact with a specific protein. Evidence indicates that a minimized human RBBP5-ASH2L heterodimer serves as the structural unit intera... | |
medium_convergence_05461 | Human polyomavirus 1 and Influenza A virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of 2.851 and an adjusted p-value of 0.009472. Which protein is encoded by this gene? | CCAAT/enhancer-binding protein gamma | Medium | convergence | {"qa_id":"medium_convergence_05461","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Influenza A virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) repor... | |
medium_convergence_05462 | COL5A1 and COL5A2 are both involved in multiple shared biological processes. One shared process is associated with evidence stating that 'Collagen fibril diameters were increased, but fibril density was decreased throughout the stroma at all developmental stages.' Which biological process is this, and what is its paren... | sensory organ morphogenesis | Medium | convergence | {"qa_id":"medium_convergence_05462","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COL5A1 and COL5A2 are both involved in multiple shared biological processes. One shared process is associated with evidence stating that 'Collagen fibril dia... | |
medium_convergence_05463 | The sphenoid bone pre-cartilage condensation and the sphenoid cartilage element share a common anatomical structure. Evidence indicates that this shared structure is composed primarily of a pre-cartilage condensation. Which anatomical structure is this shared entity a part of? | facial skeleton | Medium | convergence | {"qa_id":"medium_convergence_05463","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The sphenoid bone pre-cartilage condensation and the sphenoid cartilage element share a common anatomical structure. Evidence indicates that this shared stru... | |
medium_convergence_05464 | Both Human polyomavirus 1 and Enterovirus A are known to upregulate a specific gene. Experimental data for this gene in renal epithelial cells (from study GSE135833) reports a log2 fold change of approximately 1.499 and an adjusted p-value of 0.003227. Which disease is associated with this gene? | autism spectrum disorder due to AUTS2 deficiency | Medium | convergence | {"qa_id":"medium_convergence_05464","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human polyomavirus 1 and Enterovirus A are known to upregulate a specific gene. Experimental data for this gene in renal epithelial cells (from study GS... | |
medium_convergence_05465 | CNOT7 and CNOT3 share interaction partners. One such shared partner is MEX-3C, a canonical RNA-binding ubiquitin ligase that associates with cytoplasmic deadenylation complexes and ubiquitinates CNOT7 (also known as Caf1), the main catalytic subunit of the CCR4-NOT deadenylation machinery. Which protein is encoded by t... | RNA-binding E3 ubiquitin-protein ligase MEX3C | Medium | convergence | {"qa_id":"medium_convergence_05465","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNOT7 and CNOT3 share interaction partners. One such shared partner is MEX-3C, a canonical RNA-binding ubiquitin ligase that associates with cytoplasmic dead... | |
medium_convergence_05466 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene has a log2 fold change of approximately -1.897 and an adjusted p-value of 0.003339. Which protein is encoded by this gene? | C-C motif chemokine 2 | Medium | convergence | {"qa_id":"medium_convergence_05466","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_05467 | PSMA3 and PSMA5 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein is encoded by this shared partner? | Proteasome subunit alpha type-7 | Medium | convergence | {"qa_id":"medium_convergence_05467","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA3 and PSMA5 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S prote... | |
medium_convergence_05468 | Glimepiride and Acetohexamide both interact with a specific shared drug. Clinical evidence indicates that administering the enanthate ester of this shared drug to patients resulted in increased plasma levels of the drug, reduced plasma hsCRP, and improved insulin sensitivity. Which disease is this shared drug indicated... | hypogonadotropic hypogonadism | Medium | convergence | {"qa_id":"medium_convergence_05468","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Glimepiride and Acetohexamide both interact with a specific shared drug. Clinical evidence indicates that administering the enanthate ester of this shared dr... | |
medium_convergence_05470 | Both the androgen receptor (AR) and the protein encoded by the PRKN gene (PARK2) share interaction partners. One such shared partner was identified as a novel binding partner of AR in luteinized granulosa cells, with the interaction confirmed by co-immunoprecipitation, co-localization, and GST pull-down assays. Which p... | Phosphoglycerate kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_05470","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the androgen receptor (AR) and the protein encoded by the PRKN gene (PARK2) share interaction partners. One such shared partner was identified as a nove... | |
medium_convergence_05472 | NRAS and RAC1 share interaction partners. One such shared partner is distinguished by evidence showing that a specific guanine nucleotide exchange factor specifically interacts with both dominant negative and nucleotide-free forms of H-Ras and this partner, but not with their corresponding oncogenic forms. Which protei... | Rap1 GTPase-GDP dissociation stimulator 1 | Medium | convergence | {"qa_id":"medium_convergence_05472","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NRAS and RAC1 share interaction partners. One such shared partner is distinguished by evidence showing that a specific guanine nucleotide exchange factor spe... | |
medium_convergence_05473 | SORBS1 and EGFR both interact with a shared protein. Evidence regarding this shared protein states: 'Using yeast two-hybrid, GST-pulldown, and coimmunoprecipitation studies, we isolated the CAP cDNA as a specific partner of the proline-rich domain of this shared protein and showed by GST-pulldown experiments that the i... | opsismodysplasia | Medium | convergence | {"qa_id":"medium_convergence_05473","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SORBS1 and EGFR both interact with a shared protein. Evidence regarding this shared protein states: 'Using yeast two-hybrid, GST-pulldown, and coimmunoprecip... | |
medium_convergence_05475 | Human betaherpesvirus 5 and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line shows a log2 fold change of approximately -1.395 and an adjusted p-value of 0.04109. In which cell type is this gene enriched? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_05475","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line shows a lo... | |
medium_convergence_05476 | YAP1 and ERBB2 both interact with a shared protein. Evidence indicates that the c-erbB-2 gene product associates directly with this protein (along with beta-catenin) through its cytoplasmic domain core region, which shares extensive homology with the epidermal growth factor receptor. Which protein is encoded by the gen... | Junction plakoglobin | Medium | convergence | {"qa_id":"medium_convergence_05476","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and ERBB2 both interact with a shared protein. Evidence indicates that the c-erbB-2 gene product associates directly with this protein (along with beta-... | |
medium_convergence_05477 | BRD4 and the histone variant H1.2 (encoded by HIST1H1C) share common interaction partners. One such shared partner is involved in a complex where H1.2 stably interacts with Cul4A E3 ubiquitin ligase, and this interaction potentiates target gene transcription via induction of H4K31 ubiquitylation, H3K4me3, and H3K79me2.... | RNA polymerase II-associated factor 1 homolog | Medium | convergence | {"qa_id":"medium_convergence_05477","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and the histone variant H1.2 (encoded by HIST1H1C) share common interaction partners. One such shared partner is involved in a complex where H1.2 stably... | |
medium_convergence_05478 | LRRK2 and SFN share multiple interacting partners. One such shared partner is described in evidence stating: 'We recently demonstrated that LRRK2 binds to MKK6, -3, and -7.' Which protein is encoded by this shared interacting partner? | Dual specificity mitogen-activated protein kinase kinase 3 | Medium | convergence | {"qa_id":"medium_convergence_05478","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LRRK2 and SFN share multiple interacting partners. One such shared partner is described in evidence stating: 'We recently demonstrated that LRRK2 binds to MK... | |
medium_convergence_05479 | DSG2 and JUP each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We found that this protein binds all three desmogleins, desmocollin (Dsc) 3a and -3b, and possibly also Dsc1a and -2a.' Which protein is encoded by that shared partner? | Plakophilin-3 | Medium | convergence | {"qa_id":"medium_convergence_05479","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DSG2 and JUP each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We found that this protein binds a... | |
medium_convergence_05480 | NUP188 and NUP153 both interact with a common protein partner. Evidence indicates that this shared partner is a GDP-binding protein and that the interaction is mediated by the zinc finger region of NUP153. Which disease is associated with this shared protein partner through genomic alterations? | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_05480","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUP188 and NUP153 both interact with a common protein partner. Evidence indicates that this shared partner is a GDP-binding protein and that the interaction ... | |
medium_convergence_05481 | EGFR and SMAD3 share multiple interacting partners. One such shared partner has been demonstrated to interact with EGFR both physically and functionally in Hep3B human hepatoma cells. Which protein is encoded by this shared partner? | M-phase inducer phosphatase 1 | Medium | convergence | {"qa_id":"medium_convergence_05481","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and SMAD3 share multiple interacting partners. One such shared partner has been demonstrated to interact with EGFR both physically and functionally in H... | |
medium_convergence_05482 | Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus both downregulate a specific gene. Evidence for this gene in gamma delta T-lymphocytes (from study GSE13906) reports a log2 fold change of -2.398 and an adjusted p-value of 0.04148. Which molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05482","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus both downregulate a specific gene. Evidence for this gene in gamma delta T... | |
medium_convergence_05483 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of approximately -1.148 and an adjusted p-value of approximately 0.0403. Which prote... | Stanniocalcin-2 | Medium | convergence | {"qa_id":"medium_convergence_05483","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data ... | |
medium_convergence_05484 | CTTN and RB1 both interact with a specific protein. Evidence indicates that Cortactin, HS1, and HIP-55 are direct substrates of the protein encoded by this gene. Which protein is encoded by this gene? | Caspase-3 | Medium | convergence | {"qa_id":"medium_convergence_05484","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTTN and RB1 both interact with a specific protein. Evidence indicates that Cortactin, HS1, and HIP-55 are direct substrates of the protein encoded by this g... | |
medium_convergence_05485 | YAP1 and EGFR share common interaction partners. One such partner is described in experimental evidence as binding to YAP1 and mediating the ubiquitination and degradation of YAP1. Which protein is encoded by this specific interaction partner? | E3 ubiquitin-protein ligase NEDD4-like | Medium | convergence | {"qa_id":"medium_convergence_05485","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and EGFR share common interaction partners. One such partner is described in experimental evidence as binding to YAP1 and mediating the ubiquitination a... | |
medium_convergence_05486 | Both Zaire ebolavirus and Zika virus have been shown to downregulate the expression of a specific host gene. In a study of retinal pigment epithelium cells (GSE100839), this gene exhibited a log2 fold change of approximately -1.798 and an adjusted p-value of 1.84e-07. What molecular function is enabled by the protein p... | transcription corepressor activity | Medium | convergence | {"qa_id":"medium_convergence_05486","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Zaire ebolavirus and Zika virus have been shown to downregulate the expression of a specific host gene. In a study of retinal pigment epithelium cells (... | |
medium_convergence_05487 | EGFR and ABL1 share common interaction partners. One such shared partner is characterized by evidence stating: 'The results show that the c-Abl SH3 domain binds directly to a proline-rich site (amino acids 567-576) in the C-terminal region of the protein encoded by this partner gene.' Which protein is encoded by the ge... | Tyrosine-protein kinase ABL2 | Medium | convergence | {"qa_id":"medium_convergence_05487","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ABL1 share common interaction partners. One such shared partner is characterized by evidence stating: 'The results show that the c-Abl SH3 domain bi... | |
medium_convergence_05488 | FAF2 and MAPK1 share multiple interacting partners. One such partner is described by the finding: 'We found that ERK1 and ERK2 interact with this partner in cells and mediate its phosphorylation in vivo and in vitro.' Which disease is associated with this specific interacting partner via a biomarker relationship? | kwashiorkor | Medium | convergence | {"qa_id":"medium_convergence_05488","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAF2 and MAPK1 share multiple interacting partners. One such partner is described by the finding: 'We found that ERK1 and ERK2 interact with this partner in ... | |
medium_convergence_05489 | Methotrexate and Repaglinide share a common interacting drug. Evidence regarding this shared entity states: 'The three fibrates inhibited CYP2C8 (Ki: bezafibrate 9.7 microM, gemfibrozil 30.4 microM and the shared entity 92.6 microM) and repaglinide metabolism (IC50: bezafibrate 37.7 microM, gemfibrozil 111 microM and t... | inherited lipid metabolism disorder | Medium | convergence | {"qa_id":"medium_convergence_05489","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Methotrexate and Repaglinide share a common interacting drug. Evidence regarding this shared entity states: 'The three fibrates inhibited CYP2C8 (Ki: bezafib... | |
medium_convergence_05490 | FHL2 and GATA4 both interact with a specific transcription factor. Evidence indicates that this transcription factor physically interacts with FHL2, and that FHL2 binds to the promoters of genes responsive to this transcription factor in smooth muscle cells, but not to the promoters of immediate-early genes, in respons... | Serum response factor | Medium | convergence | {"qa_id":"medium_convergence_05490","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FHL2 and GATA4 both interact with a specific transcription factor. Evidence indicates that this transcription factor physically interacts with FHL2, and that... | |
medium_convergence_05491 | ATM and BARD1 both interact with a specific protein. Evidence regarding this protein states: 'The 97-kDa full-length (FL) BARD1 coimmunoprecipitates with BRCA1, but the 82-kDa BARD1beta coimmunoprecipitates with Aurora B and this protein.' Which protein is encoded by the gene corresponding to this interaction partner? | Breast cancer type 2 susceptibility protein | Medium | convergence | {"qa_id":"medium_convergence_05491","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and BARD1 both interact with a specific protein. Evidence regarding this protein states: 'The 97-kDa full-length (FL) BARD1 coimmunoprecipitates with BRC... | |
medium_convergence_05492 | ATF2 and FOSL2 both interact with a specific transcription factor. Evidence indicates that the protein product of this gene can form a complex with HB16, whereas c-Fos cannot. Which protein is encoded by this shared interaction partner? | Transcription factor Jun | Medium | convergence | {"qa_id":"medium_convergence_05492","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATF2 and FOSL2 both interact with a specific transcription factor. Evidence indicates that the protein product of this gene can form a complex with HB16, whe... | |
medium_convergence_05493 | RAD51 and BLM both interact with a common partner protein. Experimental evidence indicates that phosphorylation of RAD51 by c-Abl enhances the formation of a complex between RAD51 and this partner, which cooperates with RAD51 in recombination and repair. Which gene interacts with this partner protein? | SUMO1 | Medium | convergence | {"qa_id":"medium_convergence_05493","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51 and BLM both interact with a common partner protein. Experimental evidence indicates that phosphorylation of RAD51 by c-Abl enhances the formation of a... | |
medium_convergence_05494 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately -3.335 and an adjusted p-value of 0.02044. Which protein is encoded by this gene? | Double-stranded RNA-specific editase 1 | Medium | convergence | {"qa_id":"medium_convergence_05494","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) ind... | |
medium_convergence_05495 | EPC2 and MBTD1 both interact with a common protein partner. Research indicates that this partner functions as a stable subunit of a complex, utilizing a histone reader domain for H4K20me1/2 to enable TIP60 association with specific gene promoters and to facilitate DNA double-strand break repair via homologous recombina... | E1A-binding protein p400 | Medium | convergence | {"qa_id":"medium_convergence_05495","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPC2 and MBTD1 both interact with a common protein partner. Research indicates that this partner functions as a stable subunit of a complex, utilizing a hist... | |
medium_convergence_05496 | Both Human alphaherpesvirus 3 and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.182 and an adjusted p-value of 3.76e-08. Which protein is encoded by this gene... | Glucoside xylosyltransferase 1 | Medium | convergence | {"qa_id":"medium_convergence_05496","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line study ... | |
medium_convergence_05497 | MED10 and HELZ2 share multiple protein interaction partners. One such shared partner is identified in a study comparing MudPIT data sets from six independent Mediator preparations, which were immunoaffinity purified through subunits including Nut2 (MED10), Med25 (MED9), Intersex, LCMR1, AK007855, or CRSP70 (MED26). The... | Mediator of RNA polymerase II transcription subunit 29 | Medium | convergence | {"qa_id":"medium_convergence_05497","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED10 and HELZ2 share multiple protein interaction partners. One such shared partner is identified in a study comparing MudPIT data sets from six independent... | |
medium_convergence_05498 | LAMTOR2 and ATP6V1H each interact with more than one shared protein. Evidence concerning one shared entity describes it as an uncharacterized protein with sequence similarity to amino acid transporters, functioning as a lysosomal transmembrane protein that interacts with the Rag guanosine triphosphatases (GTPases) and ... | Neutral amino acid transporter 9 | Medium | convergence | {"qa_id":"medium_convergence_05498","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR2 and ATP6V1H each interact with more than one shared protein. Evidence concerning one shared entity describes it as an uncharacterized protein with se... | |
medium_convergence_05499 | CTSL and HSPA8 both interact with a shared gene product. Evidence for one such shared entity states: 'Like other Hsp40 proteins, ABBP-2 binds to Hsp70 and has ATPase-stimulating activity.' Which disease is associated with this specific entity? | polycystic kidney disease 6 with or without polycystic liver disease | Medium | convergence | {"qa_id":"medium_convergence_05499","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTSL and HSPA8 both interact with a shared gene product. Evidence for one such shared entity states: 'Like other Hsp40 proteins, ABBP-2 binds to Hsp70 and ha... | |
medium_convergence_05500 | ACTR1A and BET1 both interact with a shared protein partner. Evidence regarding this partner states: 'Affinity chromatography experiments demonstrate that the shared partner binds directly to the Arp1 subunit of dynactin.' Which disease is associated with this shared protein partner through genomic alterations? | cystic fibrosis | Medium | convergence | {"qa_id":"medium_convergence_05500","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR1A and BET1 both interact with a shared protein partner. Evidence regarding this partner states: 'Affinity chromatography experiments demonstrate that th... | |
medium_convergence_05501 | HIST3H3 and H3C1 share common interacting partners. One such shared partner is characterized by evidence stating: 'Using a stable isotope labeling by amino acids in cell culture (SILAC)-based proteomic screening we show that the basal transcription factor TFIID directly binds to the H3K4me3 mark via the plant homeodoma... | Transcription initiation factor TFIID subunit 3 | Medium | convergence | {"qa_id":"medium_convergence_05501","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIST3H3 and H3C1 share common interacting partners. One such shared partner is characterized by evidence stating: 'Using a stable isotope labeling by amino a... | |
medium_convergence_05502 | Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately 1.31 and an adjusted p-value of approximately 0.0366. Which cellular component is the protein product of this gene located in? | late endosome | Medium | convergence | {"qa_id":"medium_convergence_05502","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_05503 | PRKAB1 and ATG13 both interact with a shared protein partner. Evidence regarding this partner states: 'In addition to binding of each noncatalytic subunit to the alpha subunit, the beta and gamma subunits bind to each other, likely resulting in a more stable heterotrimeric complex.' Which protein is encoded by this sha... | 5'-AMP-activated protein kinase subunit gamma-1 | Medium | convergence | {"qa_id":"medium_convergence_05503","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKAB1 and ATG13 both interact with a shared protein partner. Evidence regarding this partner states: 'In addition to binding of each noncatalytic subunit to... | |
medium_convergence_05504 | CREBBP and HDAC3 both interact with a shared protein. Evidence regarding this shared protein states: 'The HDAC activity of this protein maps to a carboxyl-terminal domain and is dependent on the interaction with the class I HDAC, HDAC3, in the cell nucleus.' Which cell type is this shared protein enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05504","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and HDAC3 both interact with a shared protein. Evidence regarding this shared protein states: 'The HDAC activity of this protein maps to a carboxyl-te... | |
medium_convergence_05505 | JAK2 and KIT each interact with more than one shared protein. Evidence concerning one of these shared entities reports: 'Pull-down experiments using GST (glutathione transferase)-fusion proteins of the different domains of c-Kit showed that a specific adapter protein almost exclusively binds to the phosphorylated juxta... | SH2B adapter protein 3 | Medium | convergence | {"qa_id":"medium_convergence_05505","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JAK2 and KIT each interact with more than one shared protein. Evidence concerning one of these shared entities reports: 'Pull-down experiments using GST (glu... | |
medium_convergence_05506 | KAT2A and TAF10 share a common interaction partner. Evidence regarding one such partner states: 'Here we show that Myc co-recruits this entity and GCN5 via direct physical interactions of its N-terminal activation/transformation domain with the human STAGA (SPT3-TAF-GCN5 acetylase) coactivator complex.' Which disease i... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_05506","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT2A and TAF10 share a common interaction partner. Evidence regarding one such partner states: 'Here we show that Myc co-recruits this entity and GCN5 via d... | |
medium_convergence_05507 | GRPEL2 and HSPA9 both interact with a shared mitochondrial protein. Evidence indicates that this shared entity is a peripheral inner-membrane protein that tethers the complex to the import channel. Which protein product is encoded by the gene corresponding to this shared entity? | Mitochondrial import inner membrane translocase subunit TIM44 | Medium | convergence | {"qa_id":"medium_convergence_05507","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRPEL2 and HSPA9 both interact with a shared mitochondrial protein. Evidence indicates that this shared entity is a peripheral inner-membrane protein that te... | |
medium_convergence_05508 | Both Measles morbillivirus and Human orthopneumovirus are associated with the upregulation of a specific gene. In a study (GSE131840), this gene exhibited a log2 fold change of approximately 3.23 and an adjusted p-value of approximately 0.00036. Which protein is encoded by this gene? | Endothelial lipase | Medium | convergence | {"qa_id":"medium_convergence_05508","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Human orthopneumovirus are associated with the upregulation of a specific gene. In a study (GSE131840), this gene exhibited a ... | |
medium_convergence_05510 | Both Zaire ebolavirus and Zika virus are known to downregulate a specific gene. Experimental data from a study on retinal pigment epithelium cells (GSE100839) indicates that this gene exhibits a log2 fold change of approximately -1.28 and an adjusted p-value of 0.0011. Which protein does this gene product bind to? | SH3GL2 | Medium | convergence | {"qa_id":"medium_convergence_05510","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Zaire ebolavirus and Zika virus are known to downregulate a specific gene. Experimental data from a study on retinal pigment epithelium cells (GSE100839... | |
medium_convergence_05512 | NOD2 and MAP3K7 (TAK1) both interact with a specific adaptor protein. Evidence indicates that this adaptor protein forms a complex with TAK1 and TAB1, and is functionally related to another complex containing TAK1, TAB1, and TAB3. Which protein is encoded by the gene corresponding to this adaptor protein? | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05512","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NOD2 and MAP3K7 (TAK1) both interact with a specific adaptor protein. Evidence indicates that this adaptor protein forms a complex with TAK1 and TAB1, and is... | |
medium_convergence_05513 | HDAC2 and NFIA share common interaction partners. One such partner is implicated in a study showing that ATRA-induced phosphorylation of HDAC2 at Ser424 in vascular smooth muscle cells inhibits the interaction between HDAC2 and this partner. Which protein is encoded by the gene corresponding to this interaction partner... | Krueppel-like factor 4 | Medium | convergence | {"qa_id":"medium_convergence_05513","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and NFIA share common interaction partners. One such partner is implicated in a study showing that ATRA-induced phosphorylation of HDAC2 at Ser424 in v... | |
medium_convergence_05514 | MPP7 and KCNJ12 share common interaction partners. One such partner is implicated in a study stating: 'We further demonstrated by using in vitro protein interaction assays that SAP97, Veli-1, or Veli-3 binds directly to the Kir2.2 C terminus and recruits CASK.' Which protein is encoded by the gene corresponding to this... | Protein lin-7 homolog C | Medium | convergence | {"qa_id":"medium_convergence_05514","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MPP7 and KCNJ12 share common interaction partners. One such partner is implicated in a study stating: 'We further demonstrated by using in vitro protein inte... | |
medium_convergence_05515 | Hepacivirus C and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE119117) shows a log2 fold change of -1.410 and an adjusted p-value of 0.01368. Which disease is associated with this gene as a biomarker? | renal fibrosis | Medium | convergence | {"qa_id":"medium_convergence_05515","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE11... | |
medium_convergence_05516 | NEDD4L and PRKN (PARK2) both interact with a shared protein. Evidence regarding this shared protein states: 'Further evidence for the importance of this protein in this process comes from the ability of Nedd4-2 to bind to it.' Which protein is encoded by the gene corresponding to this shared entity? | Serine/threonine-protein kinase WNK1 | Medium | convergence | {"qa_id":"medium_convergence_05516","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and PRKN (PARK2) both interact with a shared protein. Evidence regarding this shared protein states: 'Further evidence for the importance of this prot... | |
medium_convergence_05517 | UBE2D1 and UBE2D2 both interact with a shared protein. Biochemical characterization of recombinant versions of this shared protein and UBE2D demonstrated that they form a stable, stoichiometric complex that can be purified to near homogeneity. Which protein is encoded by the gene corresponding to this shared entity? | Ubiquitin domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05517","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBE2D1 and UBE2D2 both interact with a shared protein. Biochemical characterization of recombinant versions of this shared protein and UBE2D demonstrated tha... | |
medium_convergence_05518 | Dengue virus and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of approximately -1.48 and an adjusted p-value of approximately 0.0436. Which protein is encoded by this gene? | CREB3 regulatory factor | Medium | convergence | {"qa_id":"medium_convergence_05518","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold... | |
medium_convergence_05519 | PPP2CA and PPP2R1B share multiple interacting partners. One such shared partner is distinguished by the following localization pattern: when complexed with the protein phosphatase 2A A and C subunits, B56alpha, B56beta, and this specific isoform localize to the cytoplasm, whereas B56delta, B56gamma1, and B56gamma3 are ... | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_05519","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CA and PPP2R1B share multiple interacting partners. One such shared partner is distinguished by the following localization pattern: when complexed with t... | |
medium_convergence_05520 | Human mastadenovirus C and Pegivirus C both downregulate a specific gene. Experimental data for this gene in lung fibroblast cell lines (study GSE120891) shows a log2 fold change of approximately -1.16 and an adjusted p-value of 0.038. Which protein is encoded by this gene? | Cytochrome c oxidase assembly factor 5 | Medium | convergence | {"qa_id":"medium_convergence_05520","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human mastadenovirus C and Pegivirus C both downregulate a specific gene. Experimental data for this gene in lung fibroblast cell lines (study GSE120891) sho... | |
medium_convergence_05521 | DNMT1 and AKT1 share a common interacting partner. Evidence indicates that this shared partner physically associates with DNMT1 and can deacetylate acetylated DNMT1 in vitro and in vivo. Which protein is encoded by this shared interacting partner? | NAD-dependent protein deacetylase sirtuin-1 | Medium | convergence | {"qa_id":"medium_convergence_05521","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT1 and AKT1 share a common interacting partner. Evidence indicates that this shared partner physically associates with DNMT1 and can deacetylate acetylate... | |
medium_convergence_05522 | NCK1 and PDGFC both interact with a common protein target. Experimental evidence regarding this target states: 'Competition binding and immunoprecipitation studies on cells bearing both PDGF alpha and beta receptors reveal a high affinity binding of recombinant GFD (PDGF-CC) to PDGF receptor-alpha homodimers and PDGF r... | Platelet-derived growth factor receptor alpha | Medium | convergence | {"qa_id":"medium_convergence_05522","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCK1 and PDGFC both interact with a common protein target. Experimental evidence regarding this target states: 'Competition binding and immunoprecipitation s... | |
medium_convergence_05523 | CACNG2 and EPB41L1 share a common interacting partner. Evidence indicates that this shared partner, identified as Stargazin, interacts with AMPA receptor subunits and synaptic PDZ proteins such as PSD-95. Which protein is encoded by the gene corresponding to this shared interacting partner? | Glutamate receptor 1 | Medium | convergence | {"qa_id":"medium_convergence_05523","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CACNG2 and EPB41L1 share a common interacting partner. Evidence indicates that this shared partner, identified as Stargazin, interacts with AMPA receptor sub... | |
medium_convergence_05524 | IRAK1 and MAP3K7 (TAK1) both interact with a shared adaptor protein. Evidence indicates that this adaptor is part of a complex with TAK1 and TAB1, and also part of a complex with TAK1 and TAB3. Which cell type is this adaptor protein enriched in? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_05524","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRAK1 and MAP3K7 (TAK1) both interact with a shared adaptor protein. Evidence indicates that this adaptor is part of a complex with TAK1 and TAB1, and also p... | |
medium_convergence_05525 | Both ATR and ATRIP interact with a specific gene product. Contextual evidence indicates that the protein encoded by this gene product interacts with the checkpoint proteins ATR and Rad9. Which protein is encoded by this gene product? | Claspin | Medium | convergence | {"qa_id":"medium_convergence_05525","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ATR and ATRIP interact with a specific gene product. Contextual evidence indicates that the protein encoded by this gene product interacts with the chec... | |
medium_convergence_05526 | TCF4 and TCF12 both interact with a shared transcription factor. Evidence indicates that this shared factor binds the promoter of the melanoma metastasis-suppressing gene KiSS1 and enhances its expression through interaction with E12 (a TCF3 isoform) and TCF12. Which biological process is this shared factor involved in... | negative regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_05526","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TCF4 and TCF12 both interact with a shared transcription factor. Evidence indicates that this shared factor binds the promoter of the melanoma metastasis-sup... | |
medium_convergence_05527 | CTBP1 and HDAC2 share multiple interacting partners. One such shared partner was identified in a study where a complex of nuclear binding proteins was purified by affinity chromatography and its components were identified by mass spectrometry as Jarid1b/Plu-1, G9a, LSD1, CoREST, and the entity in question. Which diseas... | adenoma | Medium | convergence | {"qa_id":"medium_convergence_05527","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and HDAC2 share multiple interacting partners. One such shared partner was identified in a study where a complex of nuclear binding proteins was purifi... | |
medium_convergence_05528 | KAT5 and COPS5 both interact with a specific shared protein. Evidence regarding this shared entity states: 'The novel Bcl-3 interactors Jab1, Pirin, Tip60 and Bard1 are nuclear proteins which also bind to other transcription factors including c-Jun, nuclear factor I (NFI), HIV-1 Tat or the tumor suppressor and PolII ho... | B-cell lymphoma 3 protein | Medium | convergence | {"qa_id":"medium_convergence_05528","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and COPS5 both interact with a specific shared protein. Evidence regarding this shared entity states: 'The novel Bcl-3 interactors Jab1, Pirin, Tip60 an... | |
medium_convergence_05529 | CDK2 and MAPK14 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with cyclin/cyclin-dependent kinase (Cdk) complexes via a cyclin/Cdk binding consensus site located at its N-terminus. Which protein is encoded by the gene corresponding to this shared entity? | DNA replication factor Cdt1 | Medium | convergence | {"qa_id":"medium_convergence_05529","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and MAPK14 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with cyclin/cyclin-dependent kinase (Cdk)... |
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