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medium_convergence_05530 | Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of -1.366 and an adjusted p-value of 0.03026. Which disease is associated with this gene? | neurodevelopmental disorder with hypotonia, facial dysmorphism, and brain abnormalities | Medium | convergence | {"qa_id":"medium_convergence_05530","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_05531 | The laryngeal apparatus and laryngeal associated mesenchyme are both components of a shared anatomical structure. Evidence regarding this shared structure describes an apparatus located between the lungs and the buccal cavity, composed of a pair of arytenoid cartilages supported by the cricoid ring. Which anatomical en... | proximo-distal subdivision of respiratory tract | Medium | convergence | {"qa_id":"medium_convergence_05531","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The laryngeal apparatus and laryngeal associated mesenchyme are both components of a shared anatomical structure. Evidence regarding this shared structure de... | |
medium_convergence_05532 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately -2.88 and an adjusted p-value of approximately 0.017. Which protein is encoded by this gene? | TGF-beta receptor type-2 | Medium | convergence | {"qa_id":"medium_convergence_05532","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates tha... | |
medium_convergence_05533 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data from a study on hepatocytes (GSE135619) indicates that this gene exhibits a log2 fold change of approximately -2.017 and an adjusted p-value of 0.04032. Which prot... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | Medium | convergence | {"qa_id":"medium_convergence_05533","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data ... | |
medium_convergence_05534 | POU5F1 and FOXH1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Using experimental high-resolution structure determination, followed by model building and experimental validation, we found that Oct4 and this partner were able to dimerize onto DNA in distinc... | Transcription factor SOX-2 | Medium | convergence | {"qa_id":"medium_convergence_05534","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POU5F1 and FOXH1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Using experimental high-resolu... | |
medium_convergence_05535 | POU5F1 and NANOG both interact with a shared protein partner. Experimental evidence involving high-resolution structure determination, model building, and validation indicates that Oct4 (the protein product of POU5F1) and this shared partner are capable of dimerizing onto DNA in distinct conformational arrangements. Wh... | Transcription factor SOX-2 | Medium | convergence | {"qa_id":"medium_convergence_05535","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POU5F1 and NANOG both interact with a shared protein partner. Experimental evidence involving high-resolution structure determination, model building, and va... | |
medium_convergence_05536 | Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific host gene. Experimental data from a study on macrophages (GSE108897) indicates that this gene exhibits a log2 fold change of approximately -1.64 and an adjusted p-value of 0.0028. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05536","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific host gene. Experimental data from a study on macrophages (GSE108897) indicates t... | |
medium_convergence_05537 | Lenalidomide and Thalidomide share a common interacting drug. Clinical evidence highlights the excessive and unpredictable toxicity associated with combining this specific drug with either Lenalidomide or Pomalidomide. Which disease is this drug indicated for? | colorectal cancer | Medium | convergence | {"qa_id":"medium_convergence_05537","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Lenalidomide and Thalidomide share a common interacting drug. Clinical evidence highlights the excessive and unpredictable toxicity associated with combining... | |
medium_convergence_05538 | Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) shows a log2 fold change of approximately -1.715 and an adjusted p-value of 0.002578. In which cellular component is the protein product of this gene located? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_05538","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) show... | |
medium_convergence_05539 | Pharyngeal taste buds and esophageal taste buds share multiple anatomical classifications. One shared classification is an entity located in the esophagus. Which anatomical structure is this entity a part of? | digestive system | Medium | convergence | {"qa_id":"medium_convergence_05539","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Pharyngeal taste buds and esophageal taste buds share multiple anatomical classifications. One shared classification is an entity located in the esophagus. W... | |
medium_convergence_05540 | COPS5 and CSNK2A2 both interact with a shared protein subunit of the 9-1-1 complex. Experimental evidence indicates that Jab1 physically associates with the 9-1-1 complex, and this association is mediated through a direct interaction between Jab1 and this specific subunit. Which protein is encoded by the gene correspon... | Cell cycle checkpoint protein RAD1 | Medium | convergence | {"qa_id":"medium_convergence_05540","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and CSNK2A2 both interact with a shared protein subunit of the 9-1-1 complex. Experimental evidence indicates that Jab1 physically associates with the ... | |
medium_convergence_05541 | Both CYLD and RACGAP1 interact with a common protein partner. Evidence regarding one such partner states: 'We have isolated B56epsilon, a PP2A regulatory subunit, as a new MgcRacGAP partner.' Which disease is associated with this specific protein partner? | Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development | Medium | convergence | {"qa_id":"medium_convergence_05541","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CYLD and RACGAP1 interact with a common protein partner. Evidence regarding one such partner states: 'We have isolated B56epsilon, a PP2A regulatory sub... | |
medium_convergence_05542 | MEN1 and SMARCB1 both interact with a specific protein. Evidence indicates that the human SWI/SNF component hSNF5 (encoded by SMARCB1) interacts with this protein, which functions as a UV damage recognition factor, and that hSNF5 colocalizes with this protein at DNA damage sites. Which protein is encoded by the gene co... | DNA repair protein complementing XP-C cells | Medium | convergence | {"qa_id":"medium_convergence_05542","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MEN1 and SMARCB1 both interact with a specific protein. Evidence indicates that the human SWI/SNF component hSNF5 (encoded by SMARCB1) interacts with this pr... | |
medium_convergence_05543 | CSK and EGFR share multiple interacting partners. One such shared partner is characterized by the following evidence: 'Addition of EGF to the cells induces dephosphorylation of these two molecules, leads to disassociation of the [shared partner]-focal adhesion kinase-p130Cas complex, and enhances the interaction betwee... | thyrotoxicosis | Medium | convergence | {"qa_id":"medium_convergence_05543","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSK and EGFR share multiple interacting partners. One such shared partner is characterized by the following evidence: 'Addition of EGF to the cells induces d... | |
medium_convergence_05544 | RAB25 and YWHAG share a common interacting partner. Experimental evidence indicates that this shared partner, along with three other interacting proteins, associates with wild-type Rab11a, dominant-active Rab11a (Rab11aS20V), Rab11b, and RAB25. Which protein is encoded by this shared interacting partner? | Rab11 family-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05544","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAB25 and YWHAG share a common interacting partner. Experimental evidence indicates that this shared partner, along with three other interacting proteins, as... | |
medium_convergence_05545 | SMAD7 and TGFBR2 each interact with more than one shared protein. Evidence concerning one shared entity reports that it binds to the SMAD7-SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) complex and deubiquitinates and stabilizes type I TGF-β receptor (TβR-I), leading to an enhanced TGF-β signal. Which protein is ... | Ubiquitin carboxyl-terminal hydrolase 15 | Medium | convergence | {"qa_id":"medium_convergence_05545","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD7 and TGFBR2 each interact with more than one shared protein. Evidence concerning one shared entity reports that it binds to the SMAD7-SMAD specific E3 u... | |
medium_convergence_05546 | Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of -1.294 and an adjusted p-value of 0.008035. Which protein is encoded by this gene? | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like | Medium | convergence | {"qa_id":"medium_convergence_05546","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of -1.294 and an adjusted p-va... | |
medium_convergence_05547 | MEN1 and PPP1CA both interact with a specific protein. Evidence indicates that ATR and CHK1 kinase inhibitors induce Ser2205 phosphorylation of this protein in a CDK1-dependent manner, disrupting its interaction with PP1 phosphatase. Which protein is encoded by the gene corresponding to this entity? | Telomere-associated protein RIF1 | Medium | convergence | {"qa_id":"medium_convergence_05547","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MEN1 and PPP1CA both interact with a specific protein. Evidence indicates that ATR and CHK1 kinase inhibitors induce Ser2205 phosphorylation of this protein ... | |
medium_convergence_05548 | FANCE and FANCB each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In normal cells, HA-tagged FANCE protein coimmunoprecipitates with FANCA, FANCC, and this shared partner but not with FANCD2.' Which protein is encoded by the gene corresponding to that shared p... | Fanconi anemia group G protein | Medium | convergence | {"qa_id":"medium_convergence_05548","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCE and FANCB each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In normal cells, HA-tagged FANC... | |
medium_convergence_05549 | ARPC5 and AP2A2 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'This region is sufficient to confer binding to the alpha-adaptin subunit of the clathrin adaptor protein, AP-2.' Which disease is associated with that specific entity through genomic alterations? | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05549","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC5 and AP2A2 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'This region is sufficient to confe... | |
medium_convergence_05550 | PARP1 and SIRT1 share a common interaction partner. Evidence indicates that up-regulated KAT2B promotes the acetylation of this shared entity, causing it to dissociate from SIRT1, exit the nucleus, and be secreted from the cell. Which disease is associated with this entity through genomic alterations? | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_05550","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and SIRT1 share a common interaction partner. Evidence indicates that up-regulated KAT2B promotes the acetylation of this shared entity, causing it to ... | |
medium_convergence_05552 | The pontine nuclear group and the nucleus of the medulla oblongata share a common anatomical classification. Evidence regarding one such shared entity describes nuclei located in the basal pons, intermingled among descending cortical axons, which receive neocortical input and send axons across the midline to the contra... | hindbrain | Medium | convergence | {"qa_id":"medium_convergence_05552","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The pontine nuclear group and the nucleus of the medulla oblongata share a common anatomical classification. Evidence regarding one such shared entity descri... | |
medium_convergence_05553 | BIRC2 and MAP3K5 both interact with a shared protein. Evidence regarding this shared entity states: 'We show that cIAP1 and cIAP2 directly ubiquitinate [shared protein] and induce constitutive [shared protein] ubiquitination in cancer cells and demonstrate that constitutively ubiquitinated [shared protein] associates w... | Receptor-interacting serine/threonine-protein kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_05553","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and MAP3K5 both interact with a shared protein. Evidence regarding this shared entity states: 'We show that cIAP1 and cIAP2 directly ubiquitinate [shar... | |
medium_convergence_05554 | MDH2 and PRKN (PARK2) share common interaction partners. One such shared partner is described in a study where MDHDH was found to directly bind to this partner, which is identified as the 20S proteasomal core subunit alpha-type 1. In this mechanism, the partner acts as a molecular scaffold to accelerate the degradation... | Proteasome subunit alpha type-1 | Medium | convergence | {"qa_id":"medium_convergence_05554","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDH2 and PRKN (PARK2) share common interaction partners. One such shared partner is described in a study where MDHDH was found to directly bind to this partn... | |
medium_convergence_05555 | ALYREF and CPSF3 both interact with a shared protein partner. Evidence indicates that Aly directly interacts with THO subunits, specifically identifying this shared partner alongside Thoc5. Which protein product is encoded by this shared partner? | THO complex subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_05555","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALYREF and CPSF3 both interact with a shared protein partner. Evidence indicates that Aly directly interacts with THO subunits, specifically identifying this... | |
medium_convergence_05556 | Dengue virus and Human gammaherpesvirus 8 both upregulate a specific gene. In a study using a hepatoma cell line (GSE110512), this gene showed a log2 fold change of approximately 1.18 and an adjusted p-value of 0.028. Which disease is associated with genomic alterations in this gene? | Infantile nephronophthisis | Medium | convergence | {"qa_id":"medium_convergence_05556","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Human gammaherpesvirus 8 both upregulate a specific gene. In a study using a hepatoma cell line (GSE110512), this gene showed a log2 fold ch... | |
medium_convergence_05557 | ECT2 and BRD4 both interact with a shared protein. Evidence indicates that for one such shared partner, in vitro analysis demonstrated direct binding to the largest subunit, RFC-140, thereby interacting with the entire RFC complex. Which protein is encoded by this specific shared partner? | Replication factor C subunit 5 | Medium | convergence | {"qa_id":"medium_convergence_05557","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ECT2 and BRD4 both interact with a shared protein. Evidence indicates that for one such shared partner, in vitro analysis demonstrated direct binding to the ... | |
medium_convergence_05558 | Vaccinia virus and Human respirovirus 3 both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 1.635 and an adjusted p-value of 6.68e-05. Which protein does this gene product interact with? | CCNF | Medium | convergence | {"qa_id":"medium_convergence_05558","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human respirovirus 3 both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE112... | |
medium_convergence_05559 | BRCA2 and FAM175A share common interaction partners. One such shared partner is involved in a process where it forms an acid-stable biochemical complex with BRCA1 on chromatin following DNA damage. Which protein is encoded by this shared partner? | Histone H2AX | Medium | convergence | {"qa_id":"medium_convergence_05559","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCA2 and FAM175A share common interaction partners. One such shared partner is involved in a process where it forms an acid-stable biochemical complex with ... | |
medium_convergence_05560 | CPLX1 and PPFIA4 share common binding partners. One of these shared partners is described as binding in an antiparallel alpha-helical conformation to the groove between the synaptobrevin and syntaxin helices. Which disease is associated with this specific shared partner via a biomarker relationship? | epilepsy | Medium | convergence | {"qa_id":"medium_convergence_05560","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CPLX1 and PPFIA4 share common binding partners. One of these shared partners is described as binding in an antiparallel alpha-helical conformation to the gro... | |
medium_convergence_05561 | MCM5 and MCM6 both interact with a specific protein. Evidence indicates that this protein is capable of interacting with individual MCM proteins 2 through 7 when co-expressed in insect cells and can greatly increase the recovery of some recombinant MCM proteins. Which protein is encoded by the gene corresponding to thi... | Mini-chromosome maintenance complex-binding protein | Medium | convergence | {"qa_id":"medium_convergence_05561","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM5 and MCM6 both interact with a specific protein. Evidence indicates that this protein is capable of interacting with individual MCM proteins 2 through 7 ... | |
medium_convergence_05562 | CHMP4B and TSG101 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The ability of HCRP1 (which we assign the alternative name hVps37A) to interact with Tsg101 is conferred by its mod(r) domain and is shared with hVps37B and hVps37C, two other mod(r) domain-co... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05562","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and TSG101 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The ability of HCRP1 (which w... | |
medium_convergence_05563 | PSMD14 and UBQLN2 both interact with a shared gene product. Experimental evidence indicates that the wild-type form of this shared entity can homodimerize and heterodimerize with wild-type UBQLN2. Which disease is associated with this entity via genomic alterations? | Brown-Vialetto-van Laere syndrome 1 | Medium | convergence | {"qa_id":"medium_convergence_05563","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMD14 and UBQLN2 both interact with a shared gene product. Experimental evidence indicates that the wild-type form of this shared entity can homodimerize an... | |
medium_convergence_05564 | Cardiovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately 1.87 and an adjusted p-value of approximately 0.014. Which protein is encoded by this gene? | Interleukin-8 | Medium | convergence | {"qa_id":"medium_convergence_05564","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cardiovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) ... | |
medium_convergence_05565 | CSNK2B and CBX2 both interact with a shared protein partner. Evidence regarding one of these partners states: 'By crosslinking mass spectrometry, we identified novel interactions between this partner and the three non-catalytic subunits.' Which disease is associated with this specific protein partner? | Luo-Schoch-Yamamoto syndrome | Medium | convergence | {"qa_id":"medium_convergence_05565","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and CBX2 both interact with a shared protein partner. Evidence regarding one of these partners states: 'By crosslinking mass spectrometry, we identifi... | |
medium_convergence_05566 | Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE111036) show a log2 fold change of -1.374 and an adjusted p-value of 0.0288. What molecular function is enabled by this gene? | succinyl-CoA:3-oxo-acid CoA-transferase activity | Medium | convergence | {"qa_id":"medium_convergence_05566","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE... | |
medium_convergence_05567 | FGF3 and FGF23 both interact with a common protein target. Evidence indicates that the binding of FGF23 to this target (specifically the FGFR1c isoform) is stronger in osteoarthritis chondrocytes compared with normal cells. Which protein is encoded by the gene corresponding to this target? | Fibroblast growth factor receptor 1 | Medium | convergence | {"qa_id":"medium_convergence_05567","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF3 and FGF23 both interact with a common protein target. Evidence indicates that the binding of FGF23 to this target (specifically the FGFR1c isoform) is s... | |
medium_convergence_05568 | Both West Nile virus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in monocyte-derived dendritic cells (from study GSE136342) reports a log2 fold change of approximately 1.067 and an adjusted p-value of 0.04715. Which protein is encoded by this gene? | E3 ISG15--protein ligase HERC5 | Medium | convergence | {"qa_id":"medium_convergence_05568","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in monocyte-derived d... | |
medium_convergence_05571 | ALK and NEDD4 share common interaction partners. One such partner is an adaptor protein that acts as a novel binding partner for NEDD4-1, regulating its activity and its association with PTEN to control PTEN ubiquitination. Which cell type is enriched with this adaptor protein? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05571","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALK and NEDD4 share common interaction partners. One such partner is an adaptor protein that acts as a novel binding partner for NEDD4-1, regulating its acti... | |
medium_convergence_05572 | ABI2 and ABL1 both interact with a shared protein. Experimental evidence indicates that Bcr/Abl tyrosine kinase and three tyrosine-phosphorylated proteins (115, 120, and 155 kDa) are co-immunoprecipitated using an antibody against this shared protein from lysates of the human leukemia cell line K562. Which disease is a... | lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05572","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ABI2 and ABL1 both interact with a shared protein. Experimental evidence indicates that Bcr/Abl tyrosine kinase and three tyrosine-phosphorylated proteins (1... | |
medium_convergence_05573 | IKZF1 and EHMT2 both interact with a specific protein entity. Experimental evidence indicates that this entity interacts with Ikaros isoforms via a PEDLS motif located at their N-terminus, but does not interact with homologues like Aiolos that lack this motif. Which protein is encoded by this interacting entity? | C-terminal-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05573","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IKZF1 and EHMT2 both interact with a specific protein entity. Experimental evidence indicates that this entity interacts with Ikaros isoforms via a PEDLS mot... | |
medium_convergence_05574 | Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.155 and an adjusted p-value of 0.01493. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05574","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports ... | |
medium_convergence_05575 | Both Human alphaherpesvirus 1 and Influenza A virus have been shown to downregulate a specific gene. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene exhibits a log2 fold change of -1.580 and an adjusted p-value of 0.009408. Which protein is encoded by this gene? | Integrin alpha-11 | Medium | convergence | {"qa_id":"medium_convergence_05575","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Influenza A virus have been shown to downregulate a specific gene. Experimental data from a monocytic leukemia cell line (s... | |
medium_convergence_05576 | Both Hepacivirus C and Human mastadenovirus C are reported to upregulate a specific gene. Experimental evidence for this gene, derived from peripheral blood mononuclear cells, indicates a log2 fold change of approximately 1.22 and an adjusted p-value of 0.027. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05576","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Human mastadenovirus C are reported to upregulate a specific gene. Experimental evidence for this gene, derived from peripheral blood ... | |
medium_convergence_05577 | NR3C1 and STK4 both interact with a shared protein. Experimental evidence indicates that the full-length version of this shared protein interacts with GR (glucocorticoid receptor) in vitro. Which protein is encoded by this shared entity? | Small ribosomal subunit protein mS29 | Medium | convergence | {"qa_id":"medium_convergence_05577","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NR3C1 and STK4 both interact with a shared protein. Experimental evidence indicates that the full-length version of this shared protein interacts with GR (gl... | |
medium_convergence_05578 | DLG3 and DLG4 both interact with a shared protein entity. Evidence regarding this entity states: 'We have isolated here a novel protein family consisting of at least four members which specifically interact with PSD-95/SAP90 and its related proteins through the guanylate kinase domain, and named these proteins SAPAPs (... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05578","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG3 and DLG4 both interact with a shared protein entity. Evidence regarding this entity states: 'We have isolated here a novel protein family consisting of ... | |
medium_convergence_05579 | FANCD2 and FAAP100 both interact with a specific protein. Evidence regarding this protein states: 'In addition, we characterize the binding of human [the protein] with its partners, Ube2t, [the protein], and FANCI.' Which protein is encoded by the gene corresponding to this entity? | E3 ubiquitin-protein ligase FANCL | Medium | convergence | {"qa_id":"medium_convergence_05579","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCD2 and FAAP100 both interact with a specific protein. Evidence regarding this protein states: 'In addition, we characterize the binding of human [the pro... | |
medium_convergence_05581 | Both NMU and GNAQ interact with a specific receptor protein. Evidence regarding this receptor states: 'The receptors characterized in this report are activated by neuromedin U at nanomolar potency in heterologous expression systems and bind radiolabeled neuromedin U with high affinity.' Which protein is encoded by the ... | Neuromedin-U receptor 1 | Medium | convergence | {"qa_id":"medium_convergence_05581","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both NMU and GNAQ interact with a specific receptor protein. Evidence regarding this receptor states: 'The receptors characterized in this report are activat... | |
medium_convergence_05582 | DAB1 and ARHGEF2 both interact with a shared protein. Evidence indicates that signaling through specific receptors requires the interaction of their cytoplasmic tails with the intracellular adaptor protein Disabled-1 (DAB1). Which protein is encoded by the gene corresponding to this shared entity? | Low-density lipoprotein receptor-related protein 8 | Medium | convergence | {"qa_id":"medium_convergence_05582","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAB1 and ARHGEF2 both interact with a shared protein. Evidence indicates that signaling through specific receptors requires the interaction of their cytoplas... | |
medium_convergence_05583 | Both Hepacivirus C and Zaire ebolavirus are associated with the downregulation of a specific gene. Experimental data for this gene, derived from peripheral blood mononuclear cells in study GSE119117, shows a log2 fold change of approximately -1.048 and an adjusted p-value of 0.0052. Which disease is genetically associa... | dopa-responsive dystonia | Medium | convergence | {"qa_id":"medium_convergence_05583","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Zaire ebolavirus are associated with the downregulation of a specific gene. Experimental data for this gene, derived from peripheral b... | |
medium_convergence_05584 | KDM1A and NCOR1 both interact with a specific nuclear receptor. Evidence indicates that LXRs interact with corepressors, including N-CoR (NCOR1) and SMRT, and are released upon binding agonists. Which protein is encoded by this shared nuclear receptor? | Oxysterols receptor LXR-alpha | Medium | convergence | {"qa_id":"medium_convergence_05584","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KDM1A and NCOR1 both interact with a specific nuclear receptor. Evidence indicates that LXRs interact with corepressors, including N-CoR (NCOR1) and SMRT, an... | |
medium_convergence_05585 | FANCB and FAAP24 both interact with a specific protein. Evidence indicates that this protein forms a conserved DNA-remodeling complex with the histone-fold heterodimer MHF. Which protein is encoded by the gene corresponding to this interacting partner? | Fanconi anemia group M protein | Medium | convergence | {"qa_id":"medium_convergence_05585","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCB and FAAP24 both interact with a specific protein. Evidence indicates that this protein forms a conserved DNA-remodeling complex with the histone-fold h... | |
medium_convergence_05586 | OPTN and CFTR share interaction partners. One such shared partner is involved in a process where αTOS inhibits its interaction with a substrate, thereby preventing the ubiquitination and plasma membrane elimination of ΔF508-CFTR in epithelial cells, which results in increased functional CFTR channels. Which protein enc... | E3 ubiquitin-protein ligase rififylin | Medium | convergence | {"qa_id":"medium_convergence_05586","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OPTN and CFTR share interaction partners. One such shared partner is involved in a process where αTOS inhibits its interaction with a substrate, thereby prev... | |
medium_convergence_05587 | CRK and LYN both interact with a specific gene product. Experimental evidence indicates that a GST fusion protein of full-length CrkII binds to the activated PDGF beta-receptor. Which protein is encoded by this gene product? | Platelet-derived growth factor receptor beta | Medium | convergence | {"qa_id":"medium_convergence_05587","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and LYN both interact with a specific gene product. Experimental evidence indicates that a GST fusion protein of full-length CrkII binds to the activated... | |
medium_convergence_05589 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of approximately 1.287 and an adjusted p-value of 8.33e-08. In which cell type is this gene enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05589","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) sho... | |
medium_convergence_05590 | AP1S1 and AP1B1 both interact with a shared protein. Evidence regarding this shared protein states: 'Analysis using a yeast two-hybrid system has revealed that, similarly to gamma1-adaptin, gamma2-adaptin is capable of interacting not only with the sigma1 chain (called as sigma1A in this paper), the small chain of the ... | AP-1 complex subunit gamma-like 2 | Medium | convergence | {"qa_id":"medium_convergence_05590","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP1S1 and AP1B1 both interact with a shared protein. Evidence regarding this shared protein states: 'Analysis using a yeast two-hybrid system has revealed th... | |
medium_convergence_05591 | CNOT11 and EIF3A both interact with a shared protein. Evidence indicates that activating mTOR signaling with insulin increases the amount of this shared protein bound to eIF3 by as much as five-fold. Which protein is encoded by the gene corresponding to this shared entity? | Eukaryotic translation initiation factor 4 gamma 1 | Medium | convergence | {"qa_id":"medium_convergence_05591","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNOT11 and EIF3A both interact with a shared protein. Evidence indicates that activating mTOR signaling with insulin increases the amount of this shared prot... | |
medium_convergence_05592 | Hepacivirus C and Rhinovirus A both downregulate a specific gene. Evidence for this gene reports a log2 fold change of -1.141 and an adjusted p-value of 0.0001716. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05592","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Rhinovirus A both downregulate a specific gene. Evidence for this gene reports a log2 fold change of -1.141 and an adjusted p-value of 0.00... | |
medium_convergence_05593 | AKAP1 and IQGAP1 both interact with a specific regulatory subunit of protein kinase A. Experimental evidence indicates that RIalpha and RIbeta homodimers, as well as an RIalpha:RIbeta heterodimer, bind to the R-binding domain of this entity. Which protein encodes this regulatory subunit? | cAMP-dependent protein kinase type I-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_05593","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP1 and IQGAP1 both interact with a specific regulatory subunit of protein kinase A. Experimental evidence indicates that RIalpha and RIbeta homodimers, as... | |
medium_convergence_05594 | Both IRAK1 and CD14 interact with a common protein target. Experimental evidence indicates that IRAK-1 directly binds to and phosphorylates this specific target in vitro. Which protein is encoded by the gene corresponding to this target? | Interferon regulatory factor 7 | Medium | convergence | {"qa_id":"medium_convergence_05594","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IRAK1 and CD14 interact with a common protein target. Experimental evidence indicates that IRAK-1 directly binds to and phosphorylates this specific tar... | |
medium_convergence_05595 | DLG4 and CALM3 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The associations of PSD95 with Fyn and a shared partner increased at 0-24 h, 0-1 h of reperfusion, up to 6.9- and 2.1-fold relative to sham groups, respectively.' Which protein is encoded by the ... | Glutamate receptor ionotropic, NMDA 2A | Medium | convergence | {"qa_id":"medium_convergence_05595","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG4 and CALM3 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The associations of PSD95 with F... | |
medium_convergence_05596 | STIP1 and YWHAQ share multiple interacting partners. One such shared partner is described in evidence stating that 14-3-3tau binds to p21, MDM2, and the C8 subunit of the 20S proteasome during the G1 phase, thereby facilitating the proteasomal targeting of p21. Which protein is encoded by the gene corresponding to this... | Proteasome subunit alpha type-3 | Medium | convergence | {"qa_id":"medium_convergence_05596","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STIP1 and YWHAQ share multiple interacting partners. One such shared partner is described in evidence stating that 14-3-3tau binds to p21, MDM2, and the C8 s... | |
medium_convergence_05598 | BIRC2 and RNF31 both interact with a specific shared protein. Evidence indicates that this protein interacts via its PUB domain with CYLD, and a PUB interaction motif (PIM) within this protein binds to the PUB domain of the LUBAC component HOIP. Which disease is associated with this protein through genomic alterations? | brain neoplasm | Medium | convergence | {"qa_id":"medium_convergence_05598","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and RNF31 both interact with a specific shared protein. Evidence indicates that this protein interacts via its PUB domain with CYLD, and a PUB interact... | |
medium_convergence_05599 | SIN3A and HDAC2 both interact with a specific transcription factor. Evidence indicates that this factor interacts with histone methyltransferase (PRC2) and histone deacetylase (NuRD and SIN3A) complexes through their common subunit, RBBP4/7. Which disease is associated with this transcription factor as a biomarker? | stroke disorder | Medium | convergence | {"qa_id":"medium_convergence_05599","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and HDAC2 both interact with a specific transcription factor. Evidence indicates that this factor interacts with histone methyltransferase (PRC2) and h... | |
medium_convergence_05600 | Both AHR and JUN interact with a shared protein entity. Evidence regarding this entity states: 'In protein-protein interaction studies, the acidic Q-rich region bound to components of the general transcription machinery [TATA-binding protein (TBP), TAF4, and TAF6] as well as the coactivator proteins SRC-1a and TIF2.' W... | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_05600","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both AHR and JUN interact with a shared protein entity. Evidence regarding this entity states: 'In protein-protein interaction studies, the acidic Q-rich reg... | |
medium_convergence_05601 | The biological processes 'positive regulation of gamma-aminobutyric acid secretion' and 'positive regulation of glycine secretion, neurotransmission' share a common parent process. Evidence regarding one of the shared entities states: 'Any process that activates or increases the frequency, rate or extent of the regulat... | organic acid transport | Medium | convergence | {"qa_id":"medium_convergence_05601","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'positive regulation of gamma-aminobutyric acid secretion' and 'positive regulation of glycine secretion, neurotransmission' share a... | |
medium_convergence_05602 | Human alphaherpesvirus 3 and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately 1.100 and an adjusted p-value of 0.04861. Which disease is associated with this gene through genomic alterations? | Ischemic stroke | Medium | convergence | {"qa_id":"medium_convergence_05602","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a... | |
medium_convergence_05603 | HUWE1 and CTNNB1 share a common interacting partner. Evidence regarding this shared partner indicates that domain mapping results revealed its C-terminal catalytic domain is responsible for β-catenin binding and nuclear transport. Which protein is encoded by this shared interacting partner? | Ubiquitin carboxyl-terminal hydrolase 4 | Medium | convergence | {"qa_id":"medium_convergence_05603","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and CTNNB1 share a common interacting partner. Evidence regarding this shared partner indicates that domain mapping results revealed its C-terminal cat... | |
medium_convergence_05604 | AKAP10 and PRKACA both interact with a shared regulatory subunit of protein kinase A. Evidence regarding this shared entity states: 'We interrogated compound libraries using this assay in combination with a counter-screen based on luciferase complementation by the two subunits of protein kinase A (PKA).' Which protein ... | cAMP-dependent protein kinase type II-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_05604","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP10 and PRKACA both interact with a shared regulatory subunit of protein kinase A. Evidence regarding this shared entity states: 'We interrogated compound... | |
medium_convergence_05605 | FAF2 and VCP share a common interaction partner. Experimental evidence confirms that this shared partner interacts with FAF2, among other proteins, via Co-IP and confocal microscopy. Which protein is encoded by this shared interaction partner? | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein | Medium | convergence | {"qa_id":"medium_convergence_05605","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAF2 and VCP share a common interaction partner. Experimental evidence confirms that this shared partner interacts with FAF2, among other proteins, via Co-IP... | |
medium_convergence_05606 | OPTN and IKBKE each interact with more than one shared protein. Evidence concerning one shared entity reports that a specific molecule was isolated as interacting specifically with inducible IkappaB kinase (IKK-i) by the yeast two-hybrid screening procedure. Which protein is connected to that entity through the 'encode... | TRAF family member-associated NF-kappa-B activator | Medium | convergence | {"qa_id":"medium_convergence_05606","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OPTN and IKBKE each interact with more than one shared protein. Evidence concerning one shared entity reports that a specific molecule was isolated as intera... | |
medium_convergence_05607 | MTOR and ATP6V0D1 share a common binding partner. Evidence indicates that this shared partner interacts with a regulatory-associated protein of mTOR and GbetaL to form a complex that serves as the target of rapamycin. Which protein is encoded by the gene corresponding to this shared partner? | Regulatory-associated protein of mTOR | Medium | convergence | {"qa_id":"medium_convergence_05607","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTOR and ATP6V0D1 share a common binding partner. Evidence indicates that this shared partner interacts with a regulatory-associated protein of mTOR and Gbet... | |
medium_convergence_05608 | LETM1 and MCU are both involved in more than one shared biological process. Evidence regarding one of these shared processes indicates that RNAi knockdown, overexpression, and liposome reconstitution of the purified protein demonstrate that the entity is a mitochondrial Ca2+/H+ antiporter. Which biological process is c... | calcium ion transmembrane transport | Medium | convergence | {"qa_id":"medium_convergence_05608","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LETM1 and MCU are both involved in more than one shared biological process. Evidence regarding one of these shared processes indicates that RNAi knockdown, o... | |
medium_convergence_05609 | CEBPA and ESR1 share common interacting partners. One such shared partner exhibits an estrogen-responsive interaction with ERalpha. Which disease is associated with this specific shared partner via a biomarker relationship? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_05609","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPA and ESR1 share common interacting partners. One such shared partner exhibits an estrogen-responsive interaction with ERalpha. Which disease is associat... | |
medium_convergence_05611 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that for one such shared entity, the log2 fold change is approximately 1.329 and the adjusted p-value is approx... | extracellular exosome | Medium | convergence | {"qa_id":"medium_convergence_05611","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from ... | |
medium_convergence_05612 | LAMTOR2 and BRAF both interact with a shared protein. Evidence regarding this shared protein states: 'In a two-hybrid screen with p14 as a bait, we identified the mitogen-activated protein kinase (MAPK) scaffolding protein MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) partner 1 as an interacting protein... | Ragulator complex protein LAMTOR3 | Medium | convergence | {"qa_id":"medium_convergence_05612","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR2 and BRAF both interact with a shared protein. Evidence regarding this shared protein states: 'In a two-hybrid screen with p14 as a bait, we identifie... | |
medium_convergence_05613 | PKM and UBE2D3 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Here we describe a physical interaction between the HECT domain of this protein, a giant protein involved in intracellular membrane traffic, and the M2 isoform of glycolytic enzyme pyruvate kinase (M2-PK).' Which... | Probable E3 ubiquitin-protein ligase HERC1 | Medium | convergence | {"qa_id":"medium_convergence_05613","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PKM and UBE2D3 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Here we describe a physical interaction between t... | |
medium_convergence_05614 | EGFR and AREG both interact with a shared protein partner. Evidence regarding this partner states: 'By immunoprecipitation and Western blots, we showed the formation of heterodimers between all members of the family.' Which disease is associated with this protein partner through genomic alterations? | Parkinson disease | Medium | convergence | {"qa_id":"medium_convergence_05614","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and AREG both interact with a shared protein partner. Evidence regarding this partner states: 'By immunoprecipitation and Western blots, we showed the f... | |
medium_convergence_05615 | BARD1 and XRCC4 both interact with a common protein partner. Evidence indicates that the SCF(FBXW7) E3 ligase promotes the polyubiquitylation of this shared partner at lysine 296 via lysine 63 linkage, thereby enhancing its association with the Ku70/80 complex to facilitate non-homologous end joining (NHEJ) repair. Whi... | DNA repair protein Ku80 | Medium | convergence | {"qa_id":"medium_convergence_05615","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BARD1 and XRCC4 both interact with a common protein partner. Evidence indicates that the SCF(FBXW7) E3 ligase promotes the polyubiquitylation of this shared ... | |
medium_convergence_05616 | CDKN2A and CREBBP both interact with a specific protein. Evidence regarding this protein states: 'Here we show that an important tumor suppressor protein, p14ARF (alternative reading frame product of the INK4A locus) can directly inhibit the transcriptional activity of HIF-1 by sequestering its alpha subunit into the n... | Hypoxia-inducible factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_05616","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN2A and CREBBP both interact with a specific protein. Evidence regarding this protein states: 'Here we show that an important tumor suppressor protein, p1... | |
medium_convergence_05617 | HSP90AA1 and MAP3K7 share multiple interacting partners. One such shared partner is identified in evidence stating: 'Furthermore, we identify TbetaRI and TbetaRII as Hsp90-interacting proteins in vitro and in vivo.' Which disease is associated with this specific shared entity via a biomarker relationship? | systemic sclerosis | Medium | convergence | {"qa_id":"medium_convergence_05617","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and MAP3K7 share multiple interacting partners. One such shared partner is identified in evidence stating: 'Furthermore, we identify TbetaRI and Tbe... | |
medium_convergence_05619 | CSTF2T and DHX16 both interact with a shared protein. Evidence indicates that this shared protein interacts directly with DHX16 (also known as hPRP2) and with RNA. Which biological process is this shared protein involved in? | mRNA splicing, via spliceosome | Medium | convergence | {"qa_id":"medium_convergence_05619","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSTF2T and DHX16 both interact with a shared protein. Evidence indicates that this shared protein interacts directly with DHX16 (also known as hPRP2) and wit... | |
medium_convergence_05622 | PSMA2 and PSMA4 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein is encoded by this shared partner? | Proteasome subunit alpha type-5 | Medium | convergence | {"qa_id":"medium_convergence_05622","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA2 and PSMA4 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S prote... | |
medium_convergence_05624 | DAB2 and FNBP1L both interact with a shared protein partner. Evidence for one such partner states: 'The interaction between these two proteins was confirmed by a binding assay in vitro and by the co-immunoprecipitation of both proteins from renal cell lysates.' Which gene encodes this specific shared protein partner? | Low-density lipoprotein receptor-related protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05624","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAB2 and FNBP1L both interact with a shared protein partner. Evidence for one such partner states: 'The interaction between these two proteins was confirmed ... | |
medium_convergence_05625 | FGF7 and FGF10 are both involved in a shared biological process. Experimental evidence states: 'We next demonstrated that FGF7 and FGF10 were able to induce the proliferation of the epithelial cells in vitro.' Which biological process, connected to this shared regulatory function via the relation 'positively regulates'... | epithelial cell proliferation | Medium | convergence | {"qa_id":"medium_convergence_05625","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF7 and FGF10 are both involved in a shared biological process. Experimental evidence states: 'We next demonstrated that FGF7 and FGF10 were able to induce ... | |
medium_convergence_05626 | Both Human orthopneumovirus and Human immunodeficiency virus 1 are associated with the upregulation of a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.468 and an adjusted p-value of 0.02306. Which protein is encoded by this... | Leukemia inhibitory factor | Medium | convergence | {"qa_id":"medium_convergence_05626","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Human immunodeficiency virus 1 are associated with the upregulation of a specific gene. Experimental data for this gene in cy... | |
medium_convergence_05627 | BARD1 and FAM175A share multiple binding partners. One such shared partner interacts with Abraxas via coiled-coil domains on both proteins. Which disease is associated with this specific shared partner? | leiomyoma | Medium | convergence | {"qa_id":"medium_convergence_05627","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BARD1 and FAM175A share multiple binding partners. One such shared partner interacts with Abraxas via coiled-coil domains on both proteins. Which disease is ... | |
medium_convergence_05628 | Both Human alphaherpesvirus 1 and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately -1.071 and an adjusted p-value of 0.0081. Which protein is encoded by this gene? | Tumor necrosis factor ligand superfamily member 10 | Medium | convergence | {"qa_id":"medium_convergence_05628","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in a monocytic leuk... | |
medium_convergence_05629 | EIF2S3 and EIF3E each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'A direct protein-protein interaction occurs between the protein encoded by the shared partner gene and Int-6, but the analysis of different mutants of the protein encoded by the shared partner ... | Eukaryotic translation initiation factor 3 subunit L | Medium | convergence | {"qa_id":"medium_convergence_05629","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF2S3 and EIF3E each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'A direct protein-protein inter... | |
medium_convergence_05630 | CRK and CRKL each interact with more than one shared gene. Evidence concerning one shared entity reports that deduced amino acid sequence analysis revealed pp105 contains conserved motifs with p130Cas, and both pp105 and p130Cas bind to focal adhesion kinase (pp125FAK) and Crk. Which disease is connected to that entity... | Hodgkins lymphoma | Medium | convergence | {"qa_id":"medium_convergence_05630","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and CRKL each interact with more than one shared gene. Evidence concerning one shared entity reports that deduced amino acid sequence analysis revealed p... | |
medium_convergence_05631 | CHMP2A and CHMP1A both interact with a common protein partner. Evidence indicates that the ESCRT-III component CHMP2A is directed to the forming nuclear envelope through binding to this specific partner, providing an activity essential for nuclear envelope reformation. Which protein is encoded by the gene corresponding... | Charged multivesicular body protein 4b | Medium | convergence | {"qa_id":"medium_convergence_05631","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP2A and CHMP1A both interact with a common protein partner. Evidence indicates that the ESCRT-III component CHMP2A is directed to the forming nuclear enve... | |
medium_convergence_05632 | GNAI1 and ASMT both interact with a specific gene product. Evidence regarding this interaction notes that the method was validated by the co-purification of G(i) proteins, which are well-known GPCR interaction partners but difficult to identify with current protein-protein interaction assays. Which protein is encoded b... | Melatonin receptor type 1A | Medium | convergence | {"qa_id":"medium_convergence_05632","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI1 and ASMT both interact with a specific gene product. Evidence regarding this interaction notes that the method was validated by the co-purification of ... | |
medium_convergence_05633 | Dengue virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of approximately -3.005 and an adjusted p-value of 0.0422. Which protein is encoded by this gene? | Dual specificity protein phosphatase 6 | Medium | convergence | {"qa_id":"medium_convergence_05633","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold ... | |
medium_convergence_05634 | Zaire ebolavirus and Primate bocaparvovirus 1 each downregulate more than one shared gene. Evidence concerning one such shared entity reports a log2 fold change of -1.606 and an adjusted p-value of 0.0195. Which cellular component is that entity located in? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_05634","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Primate bocaparvovirus 1 each downregulate more than one shared gene. Evidence concerning one such shared entity reports a log2 fold cha... | |
medium_convergence_05635 | STUB1 and ESR1 share multiple interacting partners. One such shared partner is implicated in a mechanism where the Met receptor interacts with the C-terminus of heat shock protein 70-interacting protein (CHIP), resulting in the proteasomal degradation of the receptor in vitro. Which protein is encoded by this shared in... | Heat shock 70 kDa protein 4 | Medium | convergence | {"qa_id":"medium_convergence_05635","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and ESR1 share multiple interacting partners. One such shared partner is implicated in a mechanism where the Met receptor interacts with the C-terminus... | |
medium_convergence_05636 | CDK8 and H3C1 each interact with more than one shared protein. Evidence concerning one of these shared entities states that it physically links the CDK8 module to the Mediator complex. Which disease is associated with that specific entity? | intellectual developmental disorder 61 | Medium | convergence | {"qa_id":"medium_convergence_05636","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK8 and H3C1 each interact with more than one shared protein. Evidence concerning one of these shared entities states that it physically links the CDK8 modu... | |
medium_convergence_05638 | BIRC2 and MAP3K7 both interact with a specific shared protein. Evidence regarding this shared protein describes two distinct complexes: one comprising TAK1 complexed with the shared protein and TAB2, and the other comprising TAK1 complexed with the shared protein and TAB3. Which protein is encoded by the gene correspon... | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05638","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and MAP3K7 both interact with a specific shared protein. Evidence regarding this shared protein describes two distinct complexes: one comprising TAK1 c... | |
medium_convergence_05639 | IL12B and FOXP3 are both involved in more than one shared biological process. One of these shared processes is supported by evidence stating: 'In contrast, IL-12 mediated specific inhibition of IL-17 production.' Which biological process is connected to this shared entity through the relation 'negatively regulates'? | interleukin-17 production | Medium | convergence | {"qa_id":"medium_convergence_05639","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL12B and FOXP3 are both involved in more than one shared biological process. One of these shared processes is supported by evidence stating: 'In contrast, I... | |
medium_convergence_05640 | HMGA2 and RBX1 are both involved in a shared biological process. Evidence regarding one of these shared processes states: 'Our results establish HMGA2 as a regulator of human genes linked to mesenchymal cell differentiation, adipogenesis, and hES cell growth.' Which biological process is connected to that entity throug... | stem cell population maintenance | Medium | convergence | {"qa_id":"medium_convergence_05640","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HMGA2 and RBX1 are both involved in a shared biological process. Evidence regarding one of these shared processes states: 'Our results establish HMGA2 as a r... | |
medium_convergence_05641 | BAZ2A and MECP2 both interact with a shared protein partner. Evidence indicates that this partner is a transcriptional repressor that cofractionates with Sin3 and histone deacetylase, and is involved in the repression complex associated with methylated DNA. Which protein is encoded by the gene corresponding to this sha... | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_05641","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BAZ2A and MECP2 both interact with a shared protein partner. Evidence indicates that this partner is a transcriptional repressor that cofractionates with Sin... |
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