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medium_convergence_05642 | XRCC6 and HSP90AA1 share multiple interacting partners. One such partner is described by the following evidence: 'Two reactive clones were found to encode the dimerization domain of a mammalian telomeric protein that binds to duplex TTAGGG repeats at chromosome ends.' Which disease is associated with this specific prot... | adult T-cell leukemia/lymphoma | Medium | convergence | {"qa_id":"medium_convergence_05642","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and HSP90AA1 share multiple interacting partners. One such partner is described by the following evidence: 'Two reactive clones were found to encode th... | |
medium_convergence_05643 | ERCC1 and CENPS each share a binding partner with a specific gene. Evidence indicates that one such shared partner, a Fanconi anemia (FA) protein, associates with the histone-fold complex MHF to form a branched DNA remodeling complex that senses and repairs stalled replication forks and activates the FA DNA damage resp... | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_05643","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC1 and CENPS each share a binding partner with a specific gene. Evidence indicates that one such shared partner, a Fanconi anemia (FA) protein, associates... | |
medium_convergence_05644 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.071 and an adjusted p-value of 0.0081. In which cell type is this gene enriched? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05644","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (st... | |
medium_convergence_05645 | CTNNB1 and ARID1A share a common interaction partner. Evidence indicates that a transcriptional coactivator interacts with beta-catenin (encoded by CTNNB1) in vitro and in vivo and is critical for beta-catenin-mediated neoplastic transformation. Which protein is encoded by the gene corresponding to this shared interact... | Histone acetyltransferase p300 | Medium | convergence | {"qa_id":"medium_convergence_05645","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and ARID1A share a common interaction partner. Evidence indicates that a transcriptional coactivator interacts with beta-catenin (encoded by CTNNB1) i... | |
medium_convergence_05646 | BARD1 and BRCA1 both interact with a specific shared protein partner. Experimental evidence using NMR spectroscopy and site-directed mutagenesis has mapped the binding site on the BRCA1-BARD1 heterodimer for the Ub-conjugating enzyme UbcH5c, implicating this shared partner in the interaction. Which disease is associate... | arthritic joint disease | Medium | convergence | {"qa_id":"medium_convergence_05646","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BARD1 and BRCA1 both interact with a specific shared protein partner. Experimental evidence using NMR spectroscopy and site-directed mutagenesis has mapped t... | |
medium_convergence_05647 | Rhinovirus A and Cardiovirus A both downregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately -1.18 and an adjusted p-value of 0.0005368. Which protein is encoded by this gene? | Mitotic checkpoint serine/threonine-protein kinase BUB1 | Medium | convergence | {"qa_id":"medium_convergence_05647","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both downregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fol... | |
medium_convergence_05648 | EIF3G and EIF3I each interact with more than one shared protein partner. Evidence concerning one of these shared partners states that activating mTOR signaling with insulin increased by as much as five-fold the amount of the protein product of this partner bound to eIF3. Which protein is connected to that entity throug... | Eukaryotic translation initiation factor 4 gamma 1 | Medium | convergence | {"qa_id":"medium_convergence_05648","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3G and EIF3I each interact with more than one shared protein partner. Evidence concerning one of these shared partners states that activating mTOR signali... | |
medium_convergence_05649 | XRCC6 and PRKN share common interaction partners. One such shared partner is a protein encoded by TPT1, which has been shown to interact with p53 and the DNA-binding subunits Ku70 and Ku80 of DNA-dependent protein kinase. Which disease is associated with this shared partner via a biomarker relationship? | Lyme disease | Medium | convergence | {"qa_id":"medium_convergence_05649","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and PRKN share common interaction partners. One such shared partner is a protein encoded by TPT1, which has been shown to interact with p53 and the DNA... | |
medium_convergence_05652 | MAPT and MDM2 share multiple interacting partners. One such partner is described in evidence stating: 'The zinc-binding protein [S100 family member] has been identified as an interacting partner with the microtubule-associated protein tau.' Which protein is encoded by this gene? | Protein S100-B | Medium | convergence | {"qa_id":"medium_convergence_05652","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPT and MDM2 share multiple interacting partners. One such partner is described in evidence stating: 'The zinc-binding protein [S100 family member] has been... | |
medium_convergence_05653 | HSP90AA1 and PSEN1 share multiple interacting partners. One such shared partner is identified in evidence stating: 'Furthermore, we identify TbetaRI and TbetaRII as Hsp90-interacting proteins in vitro and in vivo.' Which disease is associated with this specific shared entity via a biomarker relationship? | systemic sclerosis | Medium | convergence | {"qa_id":"medium_convergence_05653","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and PSEN1 share multiple interacting partners. One such shared partner is identified in evidence stating: 'Furthermore, we identify TbetaRI and Tbet... | |
medium_convergence_05654 | HCK and CBL both interact with a specific shared protein. Experimental evidence indicates that a phosphatase co-immunoprecipitates with the endogenous form of this protein in the absence of CAP, as well as with the insulin receptor in CHO-IR cell extracts. Which disease is associated with this protein through genomic a... | opsismodysplasia | Medium | convergence | {"qa_id":"medium_convergence_05654","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HCK and CBL both interact with a specific shared protein. Experimental evidence indicates that a phosphatase co-immunoprecipitates with the endogenous form o... | |
medium_convergence_05655 | Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -3.90 and an adjusted p-value of 0.0161. Which biological process is this gene involved in? | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Medium | convergence | {"qa_id":"medium_convergence_05655","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE... | |
medium_convergence_05656 | CTCF and ASH2L both interact with a specific protein. Evidence regarding this protein states: 'Here we show that a minimized human RBBP5-ASH2L heterodimer is the structural unit that interacts with and activates all MLL family histone methyltransferases.' Which protein is encoded by this entity? | Histone-lysine N-methyltransferase 2C | Medium | convergence | {"qa_id":"medium_convergence_05656","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTCF and ASH2L both interact with a specific protein. Evidence regarding this protein states: 'Here we show that a minimized human RBBP5-ASH2L heterodimer is... | |
medium_convergence_05657 | FLII and STK4 each interact with more than one shared protein. Evidence concerning one such shared entity reports: 'Two-hybrid screens using FLI LRR as bait identified a novel LRR binding partner. The 0.65-kilobase pair (kb) clone from the screen survived additional rounds of stringent two-hybrid pairwise assays, estab... | Leucine-rich repeat flightless-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05657","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FLII and STK4 each interact with more than one shared protein. Evidence concerning one such shared entity reports: 'Two-hybrid screens using FLI LRR as bait ... | |
medium_convergence_05658 | BRF1 and GTF3C2 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that the protein hTFIIIC90 interacts with the hTFIIIC220, hTFIIIC110, and hTFIIIC63 subunits of TFIIIC, the hTFIIIB90 subunit of TFIIIB, and the human RPC39 (hRPC39) and hRPC62 subunits of an i... | General transcription factor 3C polypeptide 4 | Medium | convergence | {"qa_id":"medium_convergence_05658","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRF1 and GTF3C2 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that the protein hTFIIIC90 int... | |
medium_convergence_05659 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 3.16 and an adjusted p-value of 4.16e-05. Which protein is encoded by this gene? | GTP-binding protein RAD | Medium | convergence | {"qa_id":"medium_convergence_05659","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) rep... | |
medium_convergence_05660 | BIRC3 and IKBKE both interact with a shared protein. Evidence indicates that this protein physically interacts with NF-kappaB-activating kinase (IKK-i/IKKepsilon) and inhibits the dimerization of IRF-3 following TLR3 engagement by dsRNA or Newcastle disease virus infection, thereby suppressing IFN-beta promoter-depende... | mucosal-associated invariant T cell | Medium | convergence | {"qa_id":"medium_convergence_05660","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and IKBKE both interact with a shared protein. Evidence indicates that this protein physically interacts with NF-kappaB-activating kinase (IKK-i/IKKeps... | |
medium_convergence_05661 | Human alphaherpesvirus 3 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of 5.024 and an adjusted p-value of 1.057e-10. Which disease is associated with this gene through genomic alterations? | clear cell renal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05661","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in a melanoma cell line (study GSE136586) reports a log2 fo... | |
medium_convergence_05662 | RICTOR and GSK3B both interact with a shared protein. Evidence regarding one such shared partner states: 'The binding of this protein to mTORC2 was mediated by the ZnF7 domain of this protein and M1 ubiquitin chain in the mTORC2 complex.' Which cell type is enriched for this specific shared protein? | mucosal-associated invariant T cell | Medium | convergence | {"qa_id":"medium_convergence_05662","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RICTOR and GSK3B both interact with a shared protein. Evidence regarding one such shared partner states: 'The binding of this protein to mTORC2 was mediated ... | |
medium_convergence_05663 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from a study on lung fibroblast cell lines (GSE120891) indicates that this gene exhibits a log2 fold change of approximately 1.195 and an adjusted p-value of 0.04322. W... | PTGFR | Medium | convergence | {"qa_id":"medium_convergence_05663","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from ... | |
medium_convergence_05664 | PRMT5 and CREBBP both interact with a specific gene product. Evidence indicates that Mass spectrometry identified PRMT5 as a binding partner of a specific transcription factor, which it symmetrically dimethylated on residue R321 to promote transcriptional activity. Which protein is encoded by the gene corresponding to ... | Sterol regulatory element-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05664","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRMT5 and CREBBP both interact with a specific gene product. Evidence indicates that Mass spectrometry identified PRMT5 as a binding partner of a specific tr... | |
medium_convergence_05665 | CDK2 and PRKN (PARK2) share common interacting partners. One such shared partner is identified by evidence stating: 'When cdk2 was coexpressed with pol delta in Sf9 cells, pol delta was found to coimmunoprecipitate with antibodies against cdk2.' Which protein is encoded by this shared interacting partner? | DNA polymerase delta catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_05665","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and PRKN (PARK2) share common interacting partners. One such shared partner is identified by evidence stating: 'When cdk2 was coexpressed with pol delta... | |
medium_convergence_05666 | HSP90AA1 and IKBKB both interact with a shared protein. Evidence indicates that treatment with a specific peptide (conjugated to the cell-permeating TAT(47-57) peptide) increased the protein-protein interaction between this shared entity and HSP90, enhanced its mitochondrial translocation, increased the phosphorylation... | thyroid tumor | Medium | convergence | {"qa_id":"medium_convergence_05666","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and IKBKB both interact with a shared protein. Evidence indicates that treatment with a specific peptide (conjugated to the cell-permeating TAT(47-5... | |
medium_convergence_05667 | CTSB and EFEMP1 share multiple interacting partners. One specific shared partner is part of a set of eight interactions (including ANXA5, ERdj5, PDIA4, P4HB, PDIA6, SDF2L1, and TXNDC5) that were verified at the western blotting level. Which protein is encoded by this specific shared partner? | Reticulocalbin-1 | Medium | convergence | {"qa_id":"medium_convergence_05667","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTSB and EFEMP1 share multiple interacting partners. One specific shared partner is part of a set of eight interactions (including ANXA5, ERdj5, PDIA4, P4HB,... | |
medium_convergence_05668 | DIO3 and NCOR2 both interact with a specific thyroid hormone receptor. Experimental evidence indicates that in electrophoretic mobility shift assays, wild-type thyroid hormone receptor beta interacts with N-CoR in the absence of ligand, whereas T3 causes dissociation of the thyroid hormone receptor beta/N-CoR complex. ... | Thyroid hormone receptor beta | Medium | convergence | {"qa_id":"medium_convergence_05668","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIO3 and NCOR2 both interact with a specific thyroid hormone receptor. Experimental evidence indicates that in electrophoretic mobility shift assays, wild-ty... | |
medium_convergence_05669 | SIN3A and HDAC1 share multiple interaction partners. One such partner is described in the literature as 'a negative growth regulator involved in the p53 pathway, identified as a SAP30-associated protein.' Which cell type is this specific entity enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05669","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and HDAC1 share multiple interaction partners. One such partner is described in the literature as 'a negative growth regulator involved in the p53 path... | |
medium_convergence_05670 | DLG3 and DLG4 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We report a novel protein, which is highly conserved from mammals to plants and binds selectively to the third PDZ domain (PDZ3) of PSD-95 via its C terminus.' Which protein is encoded by this shared entity? | Cysteine-rich PDZ-binding protein | Medium | convergence | {"qa_id":"medium_convergence_05670","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG3 and DLG4 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We report a novel protein, which is highly conserv... | |
medium_convergence_05671 | DERL2 and SEL1L both interact with a shared protein partner. Evidence regarding one such partner states: 'In this study, we report that although both derlin1 and derlin2 are capable of binding the ERAD-specific ubiquitin ligase [shared partner], they associate with the [shared partner]-containing complex with different... | E3 ubiquitin-protein ligase synoviolin | Medium | convergence | {"qa_id":"medium_convergence_05671","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DERL2 and SEL1L both interact with a shared protein partner. Evidence regarding one such partner states: 'In this study, we report that although both derlin1... | |
medium_convergence_05672 | Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data from a non-small cell lung adenocarcinoma cell line (study GSE147507) indicates that this gene exhibits a log2 fold change of approximately -1.015 and an adjus... | Tribbles homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_05672","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental d... | |
medium_convergence_05673 | E2F1 and AKT1 both interact with a shared protein. Evidence indicates that Akt phosphorylates this shared protein at serine 21, thereby suppressing its methyltransferase activity by preventing its binding to histone H3. This modification leads to decreased lysine 27 trimethylation and the derepression of silenced genes... | Histone-lysine N-methyltransferase EZH2 | Medium | convergence | {"qa_id":"medium_convergence_05673","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F1 and AKT1 both interact with a shared protein. Evidence indicates that Akt phosphorylates this shared protein at serine 21, thereby suppressing its methy... | |
medium_convergence_05674 | MIR129-1 and MIR98 are both involved in more than one shared biological process. One such shared process is supported by evidence stating: 'In addition, we showed that miR-129-1 and miR-133 suppress angiogenesis properties such as proliferation rate, cell viability, and migration activity of human umbilical vein endoth... | vascular endothelial cell proliferation | Medium | convergence | {"qa_id":"medium_convergence_05674","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIR129-1 and MIR98 are both involved in more than one shared biological process. One such shared process is supported by evidence stating: 'In addition, we s... | |
medium_convergence_05675 | H3F3A and KPNA2 both interact with a specific shared protein. Contextual evidence states: 'Moreover, PP1α, PP1β and a specific phosphatase bind H3-H4 in vitro and in vivo, whereas only PP1α and PP1β, but not the specific phosphatase, interact with Pak2 in vivo.' Based on this clue, which protein is the shared interacto... | Protein phosphatase 1D | Medium | convergence | {"qa_id":"medium_convergence_05675","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H3F3A and KPNA2 both interact with a specific shared protein. Contextual evidence states: 'Moreover, PP1α, PP1β and a specific phosphatase bind H3-H4 in vitr... | |
medium_convergence_05676 | NUDT21 and CKB share interaction partners. One such shared partner was identified in a global yeast two-hybrid screen using monomeric B-CK as bait against a brain cDNA library, where the cis-Golgi Matrix protein (encoded by GOLGA2) was repeatedly found as a recurrent interacting partner of B-CK. Which protein is encode... | Golgin subfamily A member 2 | Medium | convergence | {"qa_id":"medium_convergence_05676","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUDT21 and CKB share interaction partners. One such shared partner was identified in a global yeast two-hybrid screen using monomeric B-CK as bait against a ... | |
medium_convergence_05677 | CEBPB and HDAC1 both interact with a shared protein. Evidence indicates that this shared protein interacts with HDAC1 in the cell and in vitro. Which protein is encoded by the gene corresponding to this shared entity? | Krueppel-like factor 5 | Medium | convergence | {"qa_id":"medium_convergence_05677","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPB and HDAC1 both interact with a shared protein. Evidence indicates that this shared protein interacts with HDAC1 in the cell and in vitro. Which protein... | |
medium_convergence_05678 | RANBP9 and HSP90AA1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'In the current study, we have identified RanBPM as a novel binding partner of TβRI by yeast two-hybrid assay.' Which protein is encoded by this shared entity? | TGF-beta receptor type-1 | Medium | convergence | {"qa_id":"medium_convergence_05678","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RANBP9 and HSP90AA1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'In the current study, we have identified Ran... | |
medium_convergence_05679 | BOP1 and TEX10 both interact with a shared protein partner. Experimental evidence indicates that mutant M1 and M5 proteins, which are associated with large pre-ribosomal complexes, co-immunoprecipitate this shared partner along with Bop1, demonstrating their proper incorporation into the PeBoW complex. Which protein is... | Ribosome biogenesis protein WDR12 | Medium | convergence | {"qa_id":"medium_convergence_05679","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BOP1 and TEX10 both interact with a shared protein partner. Experimental evidence indicates that mutant M1 and M5 proteins, which are associated with large p... | |
medium_convergence_05680 | Dengue virus and Enterovirus A both downregulate a specific gene. In a study using a hepatoma cell line (GSE110512), this gene showed a log2 fold change of -1.861 and an adjusted p-value of 0.0422. Which protein is encoded by this gene? | Histone H2A type 1-C | Medium | convergence | {"qa_id":"medium_convergence_05680","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both downregulate a specific gene. In a study using a hepatoma cell line (GSE110512), this gene showed a log2 fold change of -... | |
medium_convergence_05681 | Interferon beta-1b and Methotrexate share a common drug interaction partner. Evidence regarding this shared partner states: 'When these values for Ki obtained with PEN were compared to values obtained with methotrexate and p-aminohippurate, the values of Ki were similar, implying the presence of a similar transport car... | urinary tract infection | Medium | convergence | {"qa_id":"medium_convergence_05681","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interferon beta-1b and Methotrexate share a common drug interaction partner. Evidence regarding this shared partner states: 'When these values for Ki obtaine... | |
medium_convergence_05682 | CREBBP and GTF3A each interact with more than one shared protein. Evidence concerning one shared entity states: 'We report that TDG associates with transcriptional coactivators CBP and p300 and that the resulting complexes are competent for both the excision step of repair and histone acetylation.' Which protein is con... | Histone acetyltransferase KAT2B | Medium | convergence | {"qa_id":"medium_convergence_05682","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and GTF3A each interact with more than one shared protein. Evidence concerning one shared entity states: 'We report that TDG associates with transcrip... | |
medium_convergence_05683 | ADRA2C and GNB2 both interact with a specific G-protein gamma subunit. Evidence regarding this subunit states: 'The gamma 10 is modified by a geranylgeranyl group and is capable of interacting with beta 1 and beta 2 but not with beta 3.' Which cell type is this subunit enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05683","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRA2C and GNB2 both interact with a specific G-protein gamma subunit. Evidence regarding this subunit states: 'The gamma 10 is modified by a geranylgeranyl ... | |
medium_convergence_05684 | The biological processes 'regulation of ketone biosynthetic process' and 'regulation of fatty acid metabolic process' share a common parent process. Evidence regarding one such shared parent process states: 'Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the... | ketone metabolic process | Medium | convergence | {"qa_id":"medium_convergence_05684","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of ketone biosynthetic process' and 'regulation of fatty acid metabolic process' share a common parent process. Evidence... | |
medium_convergence_05685 | Somatotropin and Imatinib share a common interacting drug. Evidence regarding this shared entity describes the combined effects of growth hormone and its replacement treatment in heart failure. Which disease is this shared entity indicated for? | hypogonadotropic hypogonadism | Medium | convergence | {"qa_id":"medium_convergence_05685","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Somatotropin and Imatinib share a common interacting drug. Evidence regarding this shared entity describes the combined effects of growth hormone and its rep... | |
medium_convergence_05686 | Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of -1.665 and an adjusted p-value of 0.03663. Which biological process is this gene involved in? | inorganic anion transport | Medium | convergence | {"qa_id":"medium_convergence_05686","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold c... | |
medium_convergence_05688 | PSMA3 and PSMB2 both interact with a shared protein partner. Evidence regarding this partner states: 'For example, the C-terminal extension of standard subunit beta2 is required for beta2's interaction with adjacent beta3, whereas the C-terminal extension of immunosubunit beta2i is dispensable for beta2i's interaction ... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05688","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA3 and PSMB2 both interact with a shared protein partner. Evidence regarding this partner states: 'For example, the C-terminal extension of standard subun... | |
medium_convergence_05690 | ACTR3 and BAIAP2 both interact with a common protein partner. Contextual evidence notes that this partner and WAVE3, like WAVE1, associate with the Arp2/3 complex. Which protein, encoded by the gene corresponding to this shared partner, is the subject of this context? | Actin-binding protein WASF2 | Medium | convergence | {"qa_id":"medium_convergence_05690","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR3 and BAIAP2 both interact with a common protein partner. Contextual evidence notes that this partner and WAVE3, like WAVE1, associate with the Arp2/3 co... | |
medium_convergence_05691 | Both Rift Valley fever phlebovirus and Enterovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of approximately -2.002 and an adjusted p-value of 0.04806. What is the protein encoded by this gene? | Regulator of G-protein signaling 2 | Medium | convergence | {"qa_id":"medium_convergence_05691","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Rift Valley fever phlebovirus and Enterovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in SAEC cells... | |
medium_convergence_05692 | DAXX and BRD4 both interact with a shared protein. Evidence indicates that the extraterminal (ET) domain, whose function has to date not been determined, interacts with this shared entity, as well as with JMJD6, CHD4, GLTSCR1, and ATAD5. Which biological process is this shared entity involved in? | positive regulation of DNA-templated transcription | Medium | convergence | {"qa_id":"medium_convergence_05692","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and BRD4 both interact with a shared protein. Evidence indicates that the extraterminal (ET) domain, whose function has to date not been determined, int... | |
medium_convergence_05693 | LRP1 and LRP2 share common interacting partners. One such shared partner is distinguished by experimental evidence stating: 'Interestingly, while we confirmed that other LRP1 interactors we identified, including JIP1B and EB-1, were also able to bind to APP, NYGGF4 was unique in that it showed specific binding with LRP... | C-Jun-amino-terminal kinase-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05693","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LRP1 and LRP2 share common interacting partners. One such shared partner is distinguished by experimental evidence stating: 'Interestingly, while we confirme... | |
medium_convergence_05695 | WWP2 and SHMT2 both interact with a common protein partner. Evidence indicates that ABRO1, a subunit of the BRISC isopeptidase complex, competes with WWP2 to bind to this shared partner, thereby preventing WWP2-mediated ubiquitination of the partner and enhancing its stability. Which gene encodes this shared protein pa... | Lys-63-specific deubiquitinase BRCC36 | Medium | convergence | {"qa_id":"medium_convergence_05695","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WWP2 and SHMT2 both interact with a common protein partner. Evidence indicates that ABRO1, a subunit of the BRISC isopeptidase complex, competes with WWP2 to... | |
medium_convergence_05696 | SMAD7 and UBC both interact with a specific protein. Evidence indicates that this protein, similar to Smurfs, associates with SMAD7, induces its nuclear export, and enhances the binding of SMAD7 to the TGF-beta type I receptor, thereby causing the ubiquitination and degradation of the receptor. Which protein is encoded... | NEDD4-like E3 ubiquitin-protein ligase WWP1 | Medium | convergence | {"qa_id":"medium_convergence_05696","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD7 and UBC both interact with a specific protein. Evidence indicates that this protein, similar to Smurfs, associates with SMAD7, induces its nuclear expo... | |
medium_convergence_05697 | Both IKBKG and CD14 interact with a shared protein. Experimental evidence indicates that upon IL-1 stimulation, this protein acquires Lys63-linked polyubiquitin chains and specifically binds to NEMO, the regulatory subunit of the IkappaB kinase (IKK) complex. Which protein is encoded by the gene corresponding to this s... | Interleukin-1 receptor-associated kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_05697","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKG and CD14 interact with a shared protein. Experimental evidence indicates that upon IL-1 stimulation, this protein acquires Lys63-linked polyubiqui... | |
medium_convergence_05698 | TRIM28 and PRMT5 share multiple interacting partners. One such partner is characterized by evidence stating that its methyltransferase-like domain (residues 133-321) interacts with protein-arginine methyltransferase 5 (also known as Janus kinase-binding protein 1). Which protein is encoded by this specific shared partn... | rRNA 2'-O-methyltransferase fibrillarin | Medium | convergence | {"qa_id":"medium_convergence_05698","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and PRMT5 share multiple interacting partners. One such partner is characterized by evidence stating that its methyltransferase-like domain (residues ... | |
medium_convergence_05699 | Both IKZF1 and SCAI interact with a specific transcription factor. Evidence regarding this entity notes that among its many hitherto unknown interaction partners in T cells are Raptor, CHEK1, CREB1, RUNX1, SATB1, Ikaros, and Helios. Which protein is encoded by this transcription factor? | Nuclear factor of activated T-cells, cytoplasmic 2 | Medium | convergence | {"qa_id":"medium_convergence_05699","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKZF1 and SCAI interact with a specific transcription factor. Evidence regarding this entity notes that among its many hitherto unknown interaction part... | |
medium_convergence_05700 | F11R and CDC42 each interact with more than one shared protein. Evidence concerning one shared entity reports that Par6 forms a complex with this entity-GTP, with a human homologue of the multi-PDZ protein PAR-3, and with the regulatory domains of atypical protein kinase C (PKC) proteins. Which protein is connected to ... | Partitioning defective 6 homolog alpha | Medium | convergence | {"qa_id":"medium_convergence_05700","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"F11R and CDC42 each interact with more than one shared protein. Evidence concerning one shared entity reports that Par6 forms a complex with this entity-GTP,... | |
medium_convergence_05701 | DCTN1 and ESR1 share multiple interacting partners. One such partner is implicated in a mechanism where GREB1 catalyzes the O-GlcNAcylation of ERα at residues T553/S554, thereby stabilizing ERα by inhibiting its association with a specific ubiquitin ligase. Which protein is encoded by this ubiquitin ligase? | E3 ubiquitin-protein ligase ZNF598 | Medium | convergence | {"qa_id":"medium_convergence_05701","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCTN1 and ESR1 share multiple interacting partners. One such partner is implicated in a mechanism where GREB1 catalyzes the O-GlcNAcylation of ERα at residue... | |
medium_convergence_05702 | Cerebellar Golgi cell differentiation and eurydendroid cell differentiation share a common biological process. Evidence regarding one of these entities states: 'The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation ... | central nervous system development | Medium | convergence | {"qa_id":"medium_convergence_05702","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cerebellar Golgi cell differentiation and eurydendroid cell differentiation share a common biological process. Evidence regarding one of these entities state... | |
medium_convergence_05703 | GNAI2 and GNAQ both interact with a specific receptor. Evidence indicates that WDR36 co-immunoprecipitated with Gαq and promoted the interaction between TPβ and Gαq. Which gene, known to bind this receptor, is the target of the final interaction step described in the pathway extension? | TGM2 | Medium | convergence | {"qa_id":"medium_convergence_05703","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI2 and GNAQ both interact with a specific receptor. Evidence indicates that WDR36 co-immunoprecipitated with Gαq and promoted the interaction between TPβ ... | |
medium_convergence_05704 | Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data from a hepatoma cell line study (GSE110512) indicates that this gene exhibits a log2 fold change of -1.211 and an adjusted p-value of 0.005104. Which protein is encoded by this gene? | Spermatogenesis-defective protein 39 homolog | Medium | convergence | {"qa_id":"medium_convergence_05704","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data from a hepatoma cell line study (GSE110512) indicates that this gene exhibi... | |
medium_convergence_05705 | Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) show a log2 fold change of approximately -1.35 and an adjusted p-value of 0.0007046. Which protein is encoded by this gene? | BTB/POZ domain-containing protein KCTD12 | Medium | convergence | {"qa_id":"medium_convergence_05705","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in pleural mesothelio... | |
medium_convergence_05706 | CHRM3 and GNB1 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'The gamma 4 is modified by a geranylgeranyl group and is capable of interacting with both beta 1 and beta 2 but not with beta 3.' Which protein is connected to that entity through the 'encodes' rela... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | Medium | convergence | {"qa_id":"medium_convergence_05706","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHRM3 and GNB1 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'The gamma 4 is modified by a gerany... | |
medium_convergence_05707 | CENPS and CENPH each share a binding partner. Evidence concerning one such shared entity reports that Fluorescent two-hybrid analysis identified a uniquely strong CENP-S binding protein, an association confirmed by FRET, revealing a centromere-bound complex containing CENP-S, CENP-X, and that protein in proximity to hi... | H2BC8 | Medium | convergence | {"qa_id":"medium_convergence_05707","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPS and CENPH each share a binding partner. Evidence concerning one such shared entity reports that Fluorescent two-hybrid analysis identified a uniquely s... | |
medium_convergence_05708 | PRKDC and BARD1 both interact with a common protein partner. Evidence regarding this partner states: 'The DNA-dependent protein kinase (DNA-PK) controls the repair of double-stranded DNA breaks in mammalian cells. The protein kinase subunit of DNA-PK (DNA-PKcs) is targeted to DNA breaks by association with the Ku DNA-b... | DNA repair protein Ku80 | Medium | convergence | {"qa_id":"medium_convergence_05708","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKDC and BARD1 both interact with a common protein partner. Evidence regarding this partner states: 'The DNA-dependent protein kinase (DNA-PK) controls the ... | |
medium_convergence_05709 | Glimepiride and Methotrexate share a common interacting drug. Evidence indicates that Salicylates and this shared drug may decrease the plasma protein binding and renal tubular secretion of Methotrexate. Which disease is this shared drug indicated for? | gout | Medium | convergence | {"qa_id":"medium_convergence_05709","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Glimepiride and Methotrexate share a common interacting drug. Evidence indicates that Salicylates and this shared drug may decrease the plasma protein bindin... | |
medium_convergence_05710 | STX6 and STX7 share interaction partners. One such shared partner is part of a complex with syntaxin 7, syntaxin 8, vti1b, and a vesicle-associated membrane protein, which functions in the fusion of late endosomes. Which protein is encoded by this shared partner? | Vesicle-associated membrane protein 8 | Medium | convergence | {"qa_id":"medium_convergence_05710","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STX6 and STX7 share interaction partners. One such shared partner is part of a complex with syntaxin 7, syntaxin 8, vti1b, and a vesicle-associated membrane ... | |
medium_convergence_05711 | FGFR1 and HSPA8 share multiple interacting partners. One such partner is supported by evidence stating: 'Co-immunoprecipitation studies revealed that a specific tyrosine kinase directly associated with FGFR-1beta.' Which protein is encoded by this specific interacting partner? | Tyrosine-protein kinase Yes | Medium | convergence | {"qa_id":"medium_convergence_05711","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGFR1 and HSPA8 share multiple interacting partners. One such partner is supported by evidence stating: 'Co-immunoprecipitation studies revealed that a speci... | |
medium_convergence_05712 | Both Human alphaherpesvirus 3 and Hepacivirus C are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.465 and an adjusted p-value of 3.463e-06. What protein is encoded by this gene... | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | Medium | convergence | {"qa_id":"medium_convergence_05712","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Hepacivirus C are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line study ... | |
medium_convergence_05713 | AKT3 and ADAM17 are both involved in more than one shared biological process. Evidence indicates that miR-152 reduces TNF precursor cleavage and inhibits cell proliferation and migration by targeting one of these shared entities in human umbilical vein endothelial cells (HUVECs). Which biological process, connected to ... | vascular endothelial cell proliferation | Medium | convergence | {"qa_id":"medium_convergence_05713","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT3 and ADAM17 are both involved in more than one shared biological process. Evidence indicates that miR-152 reduces TNF precursor cleavage and inhibits cel... | |
medium_convergence_05714 | AKAP9 and BRAF both interact with a shared downstream effector in the MAPK signaling pathway. Evidence indicates that members of the Raf oncogene family activate mitogen-activated protein kinase kinases (MEKs) through direct interaction and phosphorylation. Specifically, interaction patterns have been dissected for Raf... | Dual specificity mitogen-activated protein kinase kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_05714","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP9 and BRAF both interact with a shared downstream effector in the MAPK signaling pathway. Evidence indicates that members of the Raf oncogene family acti... | |
medium_convergence_05715 | Doxycycline and Methotrexate share a common interacting drug. Evidence indicates that daptomycin was the common element in the most active regimens when combined with this shared drug plus either beta-lactams (specifically cefoperazone or the shared drug itself). Which disease is this shared drug indicated for? | urinary tract infection | Medium | convergence | {"qa_id":"medium_convergence_05715","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Doxycycline and Methotrexate share a common interacting drug. Evidence indicates that daptomycin was the common element in the most active regimens when comb... | |
medium_convergence_05716 | Both Human alphaherpesvirus 3 and Enterovirus A are known to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.24 and an adjusted p-value of approximately 1.08e-06. Which disease is associated with this gene as a biomar... | major depressive disorder | Medium | convergence | {"qa_id":"medium_convergence_05716","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Enterovirus A are known to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE... | |
medium_convergence_05717 | MTOR and CCNF share interaction partners. One such shared partner is described in evidence stating: 'Quantitative immunoblotting showed that the abundance of this protein is low compared with the PIKKs, and it preferentially bound newly synthesized ATM, ATR, mTOR, and DNA-PKcs.' Which disease is associated with this sh... | TELO2-related intellectual disability-neurodevelopmental disorder | Medium | convergence | {"qa_id":"medium_convergence_05717","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTOR and CCNF share interaction partners. One such shared partner is described in evidence stating: 'Quantitative immunoblotting showed that the abundance of... | |
medium_convergence_05718 | CUL2 and RBX1 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'We additionally demonstrated that Type 2B mutant pVHL forms a remnant VBC complex containing the active members ROC1 and Cullin-2 which retains the ability to ubiquitylate HIF-1alpha.' Which protei... | von Hippel-Lindau disease tumor suppressor | Medium | convergence | {"qa_id":"medium_convergence_05718","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL2 and RBX1 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'We additionally demonstrated that ... | |
medium_convergence_05719 | RANBP9 and PSME3 both interact with a specific gene product. Evidence indicates that the RanBPM protein physically interacts with the protein encoded by CDKN1A and deubiquitinates it by recruiting the deubiquitinase USP11 to maintain its protein stability. Which protein is encoded by the gene corresponding to this shar... | Cyclin-dependent kinase inhibitor 1 | Medium | convergence | {"qa_id":"medium_convergence_05719","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RANBP9 and PSME3 both interact with a specific gene product. Evidence indicates that the RanBPM protein physically interacts with the protein encoded by CDKN... | |
medium_convergence_05720 | The facial nucleus and the nucleus of the superior olivary complex share a common anatomical classification. Evidence regarding one of these shared entities describes it as 'The group of motor neurons residing in the pons that innervate the muscles of facial expression.' Which larger anatomical structure is this shared... | hindbrain | Medium | convergence | {"qa_id":"medium_convergence_05720","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The facial nucleus and the nucleus of the superior olivary complex share a common anatomical classification. Evidence regarding one of these shared entities ... | |
medium_convergence_05721 | RRP1B and NCL share multiple interacting partners. One such shared partner is supported by evidence stating that PP1delta and nucleolin were co-immunoprecipitated using anti-nucleolin and anti-PP1delta antibodies. Which protein corresponds to this shared interacting partner? | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_05721","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RRP1B and NCL share multiple interacting partners. One such shared partner is supported by evidence stating that PP1delta and nucleolin were co-immunoprecipi... | |
medium_convergence_05723 | BIRC3 and IKBKG both interact with a shared protein partner. Experimental evidence for this specific interaction indicates that it was confirmed by co-immunoprecipitation and found to be abrogated by panr2. Which protein is encoded by this shared partner? | Sharpin | Medium | convergence | {"qa_id":"medium_convergence_05723","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and IKBKG both interact with a shared protein partner. Experimental evidence for this specific interaction indicates that it was confirmed by co-immuno... | |
medium_convergence_05724 | Both Measles morbillivirus and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene indicates a log2 fold change of approximately -1.275 and an adjusted p-value of 0.0003926. Which protein is encoded by this gene? | Sodium/calcium exchanger 1 | Medium | convergence | {"qa_id":"medium_convergence_05724","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene indicates a log2 fold ... | |
medium_convergence_05725 | Fludrocortisone and Dexamethasone both interact with a specific shared drug. Evidence indicates that treatment with 4-PBA decreased the expression levels of ERS-related proteins. Which drug is this shared entity? | Deflazacort | Medium | convergence | {"qa_id":"medium_convergence_05725","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Fludrocortisone and Dexamethasone both interact with a specific shared drug. Evidence indicates that treatment with 4-PBA decreased the expression levels of ... | |
medium_convergence_05726 | DCUN1D1 and CUL1 both interact with multiple shared partners. One such shared partner is a component of the SCF (SKP1/cullin-1/F-box protein) E3 ubiquitin ligase complex. Which gene encodes this specific shared partner? | F-box only protein 7 | Medium | convergence | {"qa_id":"medium_convergence_05726","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCUN1D1 and CUL1 both interact with multiple shared partners. One such shared partner is a component of the SCF (SKP1/cullin-1/F-box protein) E3 ubiquitin li... | |
medium_convergence_05727 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from a study on cytotoxic T-lymphocytes (GSE106475) indicates that this gene exhibits a log2 fold change of approximately 3.42 and an adjusted p-value of 0.039. Which p... | PRNP | Medium | convergence | {"qa_id":"medium_convergence_05727","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from ... | |
medium_convergence_05729 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of approximately -2.10 and an adjusted p-value of approximately 0.0095. Which protein is encoded by this gene? | General transcription factor II-I repeat domain-containing protein 2B | Medium | convergence | {"qa_id":"medium_convergence_05729","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) s... | |
medium_convergence_05730 | ZFP42 and NR5A1 are both involved in more than one shared biological process. One of these shared processes is linked to a specific entity for which evidence states: 'Mutations in NR5A1 in 46,XX women are associated with primary ovarian insufficiency, which includes a lack of ovary formation, primary and secondary amen... | development of primary female sexual characteristics | Medium | convergence | {"qa_id":"medium_convergence_05730","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ZFP42 and NR5A1 are both involved in more than one shared biological process. One of these shared processes is linked to a specific entity for which evidence... | |
medium_convergence_05731 | CHMP4B and CHMP1A both interact with a shared protein partner. Evidence indicates that this partner interacts with CHMP4b/Shax (a Snf7 homologue) and EAP20 (a component of ESCRT-II), as observed by co-immunoprecipitation of epitope-tagged proteins expressed in HEK-293 cells. Which protein is encoded by the gene corresp... | Charged multivesicular body protein 6 | Medium | convergence | {"qa_id":"medium_convergence_05731","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and CHMP1A both interact with a shared protein partner. Evidence indicates that this partner interacts with CHMP4b/Shax (a Snf7 homologue) and EAP20 (... | |
medium_convergence_05733 | FANCF and FANCG both interact with a specific shared protein. Evidence indicates that MM1 interacts with the Fanconi anemia (FA) core complex by binding to this shared protein, whereas MM2 interacts with RM1 and topoisomerase IIIalpha, which are components of the BLM-Sgs1 complex (BS complex). Which protein is encoded ... | Fanconi anemia group M protein | Medium | convergence | {"qa_id":"medium_convergence_05733","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCF and FANCG both interact with a specific shared protein. Evidence indicates that MM1 interacts with the Fanconi anemia (FA) core complex by binding to t... | |
medium_convergence_05734 | CCND1 and CCND3 both interact with a specific protein kinase. Evidence indicates that the addition of p34(SEI-1) to a complex containing cyclin D1 and this kinase renders the complex resistant to inhibition by p16(INK4a). Which protein is encoded by the gene corresponding to this kinase? | Cyclin-dependent kinase 4 | Medium | convergence | {"qa_id":"medium_convergence_05734","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCND1 and CCND3 both interact with a specific protein kinase. Evidence indicates that the addition of p34(SEI-1) to a complex containing cyclin D1 and this k... | |
medium_convergence_05735 | ADAM22 and ADAM23 both interact with a specific shared protein. Evidence indicates that this shared protein is a transmembrane protein which, when mutated, causes seizures, and that ADAM22 serves as a receptor for it. Which protein is encoded by this shared entity? | Leucine-rich glioma-inactivated protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05735","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADAM22 and ADAM23 both interact with a specific shared protein. Evidence indicates that this shared protein is a transmembrane protein which, when mutated, c... | |
medium_convergence_05736 | YWHAQ and KRAS share multiple interacting partners. One such partner is associated with evidence stating: 'Four 14-3-3 isoforms (beta, epsilon, eta, tau) were identified interacting with the hPFTAIRE1.' Which protein corresponds to this shared partner, and what protein product does it encode? | Cyclin-dependent kinase 14 | Medium | convergence | {"qa_id":"medium_convergence_05736","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and KRAS share multiple interacting partners. One such partner is associated with evidence stating: 'Four 14-3-3 isoforms (beta, epsilon, eta, tau) wer... | |
medium_convergence_05737 | FLII and ANLN both interact with a shared protein. Evidence regarding this shared entity states: 'We report the identification of two related genes, LRRFIP1 and the shared entity, encoding proteins that interact with the LRR domain of human FLI using the yeast two-hybrid system.' Which protein is encoded by the gene co... | Leucine-rich repeat flightless-interacting protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05737","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FLII and ANLN both interact with a shared protein. Evidence regarding this shared entity states: 'We report the identification of two related genes, LRRFIP1 ... | |
medium_convergence_05738 | Both Human immunodeficiency virus 1 and Dengue virus are known to upregulate a specific host gene. Experimental data from a study on macrophages (GSE108897) indicates that this gene exhibits a log2 fold change of approximately 1.36 and an adjusted p-value of 0.0005993. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05738","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are known to upregulate a specific host gene. Experimental data from a study on macrophages (GSE108897) ... | |
medium_convergence_05739 | Both Vaccinia virus and Enterovirus A are associated with the downregulation of a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene exhibits a log2 fold change of approximately -1.19 and an adjusted p-value of 9.28e-05. Which protein is encoded by this g... | Prefoldin subunit 5 | Medium | convergence | {"qa_id":"medium_convergence_05739","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Enterovirus A are associated with the downregulation of a specific gene. Experimental data from a cervical adenocarcinoma cell line (... | |
medium_convergence_05740 | ATG16L1 and TRAF3 both interact with a specific shared protein. Evidence indicates that this shared protein binds to the kinase domain of the protein encoded by the gene RIPK2 and negatively regulates TLR2-mediated NF-κB activation and pro-inflammatory cytokine responses by inhibiting the interaction between TLR2 and t... | Receptor-interacting serine/threonine-protein kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_05740","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG16L1 and TRAF3 both interact with a specific shared protein. Evidence indicates that this shared protein binds to the kinase domain of the protein encoded... | |
medium_convergence_05741 | SMAD4 and SMAD7 both interact with a specific shared protein. Evidence indicates that TRIP12 recruits this shared protein to SMAD4, a process likely responsible for the inhibitory monoubiquitination of SMAD4, as both SMAD4 monoubiquitination and its interaction with this protein are significantly reduced when TRIP12 is... | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_05741","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD4 and SMAD7 both interact with a specific shared protein. Evidence indicates that TRIP12 recruits this shared protein to SMAD4, a process likely responsi... | |
medium_convergence_05742 | Both Human alphaherpesvirus 1 and Cardiovirus A are known to upregulate the expression of a specific shared gene. In a study involving a monocytic leukemia cell line (GSE114966), evidence for one such shared entity reports a log2 fold change of approximately 1.036 and an adjusted p-value of 0.005641. Which cellular com... | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_05742","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Cardiovirus A are known to upregulate the expression of a specific shared gene. In a study involving a monocytic leukemia c... | |
medium_convergence_05743 | The genes SLC29A3 and SLC22A3 both enable a shared molecular function. Evidence regarding one of these functions states: 'The plasma membrane monoamine transporter (PMAT) and organic cation transporter 3 (OCT3) are the two most prominent low-affinity, high-capacity (i.e., uptake(2)) transporters for endogenous biogenic... | active transmembrane transporter activity | Medium | convergence | {"qa_id":"medium_convergence_05743","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The genes SLC29A3 and SLC22A3 both enable a shared molecular function. Evidence regarding one of these functions states: 'The plasma membrane monoamine trans... | |
medium_convergence_05744 | EGFR and CCNE1 share a common interacting partner. Evidence indicates that this shared partner interacts with the epidermal growth factor receptor (EGFR) both physically and functionally in Hep3B human hepatoma cells. Which protein is encoded by this shared interacting partner? | M-phase inducer phosphatase 1 | Medium | convergence | {"qa_id":"medium_convergence_05744","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and CCNE1 share a common interacting partner. Evidence indicates that this shared partner interacts with the epidermal growth factor receptor (EGFR) bot... | |
medium_convergence_05745 | Human polyomavirus 1 and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of 1.059 and an adjusted p-value of 0.01824. Which protein is encoded by this gene? | High mobility group protein B2 | Medium | convergence | {"qa_id":"medium_convergence_05745","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) report... | |
medium_convergence_05746 | RAB4A and YWHAG share common interaction partners. One such partner is described in evidence stating: 'We have identified a novel 80-kDa protein that interacts specifically with the GTP-bound conformation of Rab4, and subsequent work has shown that it also interacts strongly with Rab11.' Which protein is encoded by the... | Rab11 family-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05746","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAB4A and YWHAG share common interaction partners. One such partner is described in evidence stating: 'We have identified a novel 80-kDa protein that interac... | |
medium_convergence_05749 | PARP1 and HDAC1 share multiple interacting partners. One such partner was experimentally validated to interact with PARS (the protein encoded by PARP1) using far-Western blot analysis and co-precipitation with affinity resin, following the construction of His-tagged or GST fusion proteins. Which disease is associated w... | atherosclerosis | Medium | convergence | {"qa_id":"medium_convergence_05749","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and HDAC1 share multiple interacting partners. One such partner was experimentally validated to interact with PARS (the protein encoded by PARP1) using... | |
medium_convergence_05750 | TP53 and UBE2D2 share multiple interacting partners. One such shared partner is described as an E3 ligase that forms a thioester with ubiquitin and assembles ubiquitin chains on its own lysine residues, but does not form a covalent intermediate with E2. Which cellular component is this specific shared partner located i... | P-body | Medium | convergence | {"qa_id":"medium_convergence_05750","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TP53 and UBE2D2 share multiple interacting partners. One such shared partner is described as an E3 ligase that forms a thioester with ubiquitin and assembles... | |
medium_convergence_05752 | RHOA and RHOBTB1 both interact with a specific downstream effector protein. Evidence regarding this effector states: 'The similarity of RhoE and RhoA sequences suggested that RhoE might compete with RhoA for interaction with its targets.' Which protein is encoded by the gene corresponding to this effector? | Rho-associated protein kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_05752","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOA and RHOBTB1 both interact with a specific downstream effector protein. Evidence regarding this effector states: 'The similarity of RhoE and RhoA sequenc... |
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