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medium_convergence_00752 | Both the paired limb/fin and the external soft tissue zone contain a shared anatomical component. Evidence regarding this shared component describes it as 'An appendage that is part of an appendage girdle complex.' Which anatomical structure is this shared component a part of? | vascular system | Medium | convergence | {"qa_id":"medium_convergence_00752","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the paired limb/fin and the external soft tissue zone contain a shared anatomical component. Evidence regarding this shared component describes it as 'A... | |
medium_convergence_00753 | Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this gene in a study (GSE135833) reports a log2 fold change of approximately 3.80 and an adjusted p-value of approximately 0.0104. Which cell type is this gene enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_00753","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this gene in a study (GSE135833) reports a log2 fold ch... | |
medium_convergence_00755 | CTNNB1 and BRD4 share multiple interacting partners. One such partner is described by the evidence: 'We demonstrate that USP17 directly interacts with and deubiquitinates β-catenin, preventing its degradation and enhancing its stability.' Which protein is encoded by the gene corresponding to this interacting partner? | Ubiquitin carboxyl-terminal hydrolase 17 | Medium | convergence | {"qa_id":"medium_convergence_00755","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and BRD4 share multiple interacting partners. One such partner is described by the evidence: 'We demonstrate that USP17 directly interacts with and de... | |
medium_convergence_00756 | CHMP4A and TSG101 both interact with a common protein partner. Experimental evidence indicates that this partner, along with TSG101, co-immunoprecipitated with VPS37B-FLAG, and the three proteins comigrated together in soluble complexes of the correct size for human ESCRT-I (approximately 350 kDa). Which protein is enc... | Vacuolar protein sorting-associated protein 28 homolog | Medium | convergence | {"qa_id":"medium_convergence_00756","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4A and TSG101 both interact with a common protein partner. Experimental evidence indicates that this partner, along with TSG101, co-immunoprecipitated wi... | |
medium_convergence_00757 | CTNNA2 and ULK4 are both associated with multiple shared biological processes. One of these shared processes is linked to an entity whose loss in neurons results in defects in neurite stability and migration, and which is expressed in the human cerebral cortex. Which broader biological category is this specific process... | regulation of cell migration | Medium | convergence | {"qa_id":"medium_convergence_00757","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNA2 and ULK4 are both associated with multiple shared biological processes. One of these shared processes is linked to an entity whose loss in neurons res... | |
medium_convergence_00758 | BIRC2 and BIRC3 both interact with a shared protein. Evidence regarding this shared entity states: 'The N-terminal (BIR1) and C-terminal (BIR3) BIR domains of cIAP1 were determined to be necessary and sufficient for binding TRAF2 and a specific apoptotic regulator, respectively.' Which molecular function is enabled by ... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_00758","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and BIRC3 both interact with a shared protein. Evidence regarding this shared entity states: 'The N-terminal (BIR1) and C-terminal (BIR3) BIR domains o... | |
medium_convergence_00759 | DCUN1D1 and CUL1 both interact with a specific protein. Evidence indicates that Cullin1 binds to the N-terminus of this protein via SKP1, while Cullin7 associates with its C-terminus to form a cooperative Cullin1-SKP1-protein-Cullin7 functional complex. Which protein is encoded by the gene corresponding to this entity? | F-box/WD repeat-containing protein 8 | Medium | convergence | {"qa_id":"medium_convergence_00759","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCUN1D1 and CUL1 both interact with a specific protein. Evidence indicates that Cullin1 binds to the N-terminus of this protein via SKP1, while Cullin7 assoc... | |
medium_convergence_00760 | AKT1 and MAPK8IP2 share a common interacting partner. Evidence indicates that a direct association between this shared entity and a JNK-interacting scaffold protein was observed in primary neurons. Which protein is encoded by this shared entity? | C-Jun-amino-terminal kinase-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00760","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and MAPK8IP2 share a common interacting partner. Evidence indicates that a direct association between this shared entity and a JNK-interacting scaffold ... | |
medium_convergence_00761 | Both Orthohepevirus A and Zika virus have been shown to downregulate a specific gene. Experimental data for this gene, derived from hepatocytes in study GSE135619, reports a log2 fold change of approximately -1.296 and an adjusted p-value of 0.04032. Which protein is encoded by this gene? | Zinc finger protein 395 | Medium | convergence | {"qa_id":"medium_convergence_00761","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Zika virus have been shown to downregulate a specific gene. Experimental data for this gene, derived from hepatocytes in study GSE1... | |
medium_convergence_00762 | DLAT and PDHA1 both interact with a shared protein component of the pyruvate dehydrogenase complex. Evidence regarding this shared entity states: 'The assembled core structure of mammalian pyruvate dehydrogenase complex also includes the dihydrolipoyl dehydrogenase (E3)-binding protein that binds the I domain of E2 by ... | Pyruvate dehydrogenase protein X component, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_00762","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLAT and PDHA1 both interact with a shared protein component of the pyruvate dehydrogenase complex. Evidence regarding this shared entity states: 'The assemb... | |
medium_convergence_00763 | Vaccinia virus and Enterovirus A both downregulate a specific host gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately -4.57 and an adjusted p-value of 0.0224. In which cellular component is this gene product located? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_00763","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific host gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicate... | |
medium_convergence_00764 | BCAP31 and AGR2 share common interaction partners. One such partner is described in evidence stating: 'We show that BAP31 specifically associates with nonmuscle myosin heavy chain B and nonmuscle gamma-actin, two components of the cytoskeleton actomyosin complex.' Which protein encodes the entity identified in this evi... | Myosin-10 | Medium | convergence | {"qa_id":"medium_convergence_00764","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BCAP31 and AGR2 share common interaction partners. One such partner is described in evidence stating: 'We show that BAP31 specifically associates with nonmus... | |
medium_convergence_00765 | Both Human alphaherpesvirus 3 and Zika virus are known to downregulate a specific host gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of -1.111 and an adjusted p-value of 8.964e-05. Which protein is encoded by this gene? | Zinc transporter ZIP10 | Medium | convergence | {"qa_id":"medium_convergence_00765","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zika virus are known to downregulate a specific host gene. Experimental data from a melanoma cell line study (GSE136586) in... | |
medium_convergence_00766 | CRKL and EPHA2 both interact with a specific shared protein. Experimental evidence indicates that this shared protein binds directly to the regulatory subunit of PI3K in vitro, as demonstrated by Far Western blotting using a fusion protein containing the SH3 domain of the shared entity. Which protein is encoded by the ... | Phosphatidylinositol 3-kinase regulatory subunit beta | Medium | convergence | {"qa_id":"medium_convergence_00766","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRKL and EPHA2 both interact with a specific shared protein. Experimental evidence indicates that this shared protein binds directly to the regulatory subuni... | |
medium_convergence_00767 | GH2 and GHR each interact with more than one shared protein. Evidence concerning one shared entity reports that CIS and a second suppressor of cytokine signaling protein bound to fusions containing as few as 80 COOH-terminal residues of the growth hormone receptor, provided the fusion protein was tyrosine-phosphorylate... | Suppressor of cytokine signaling 2 | Medium | convergence | {"qa_id":"medium_convergence_00767","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GH2 and GHR each interact with more than one shared protein. Evidence concerning one shared entity reports that CIS and a second suppressor of cytokine signa... | |
medium_convergence_00768 | Prednisone and Thalidomide both interact with a specific drug. Clinical evidence indicates that for this drug, when used as monotherapy, the concurrent prescription of steroids at doses exceeding 20 mg per day was associated with worse overall survival (P for trend = .005). Which disease is this drug indicated for? | colorectal cancer | Medium | convergence | {"qa_id":"medium_convergence_00768","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Prednisone and Thalidomide both interact with a specific drug. Clinical evidence indicates that for this drug, when used as monotherapy, the concurrent presc... | |
medium_convergence_00769 | AURKB and CDC20 share common binding partners. One such shared partner is implicated in a mechanism where Aurora-B interacts with the APC/C complex specifically through this subunit, leading to Aurora-B ubiquitination and increased protein levels upon proteasome inhibition. Which gene interacts with this specific share... | CDH1 | Medium | convergence | {"qa_id":"medium_convergence_00769","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AURKB and CDC20 share common binding partners. One such shared partner is implicated in a mechanism where Aurora-B interacts with the APC/C complex specifica... | |
medium_convergence_00770 | Both Human respirovirus 3 and Zaire ebolavirus are associated with the upregulation of a specific gene. Experimental data from a non-small cell lung adenocarcinoma cell line (study GSE147507) indicates that this gene exhibits a log2 fold change of approximately 1.896 and an adjusted p-value of 0.04844. Which protein is... | Interleukin-6 | Medium | convergence | {"qa_id":"medium_convergence_00770","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Zaire ebolavirus are associated with the upregulation of a specific gene. Experimental data from a non-small cell lung adenocar... | |
medium_convergence_00771 | Lidocaine and Cyproheptadine share a common interacting drug. Evidence indicates that this shared entity enhanced the anticonvulsive action of most benzodiazepines tested. Which disease is this shared entity indicated for? | alcohol withdrawal | Medium | convergence | {"qa_id":"medium_convergence_00771","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Lidocaine and Cyproheptadine share a common interacting drug. Evidence indicates that this shared entity enhanced the anticonvulsive action of most benzodiaz... | |
medium_convergence_00772 | Measles morbillivirus and Rift Valley fever phlebovirus both upregulate a specific gene. In a study of pleural mesothelioma cells (GSE117668), this gene showed a log2 fold change of 1.351 and an adjusted p-value of 0.02852. Which protein is encoded by this gene? | 3'-5' exoribonuclease HELZ2 | Medium | convergence | {"qa_id":"medium_convergence_00772","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Rift Valley fever phlebovirus both upregulate a specific gene. In a study of pleural mesothelioma cells (GSE117668), this gene show... | |
medium_convergence_00773 | LEO1 and RNF20 both interact with a common protein partner. Evidence indicates that this shared partner interacts with the RNF20/40 complex through its C-terminal coiled-coil region and promotes the complex's E3 ligase activity for H2B ubiquitination. Which protein is encoded by this shared partner? | WW domain-containing adapter protein with coiled-coil | Medium | convergence | {"qa_id":"medium_convergence_00773","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LEO1 and RNF20 both interact with a common protein partner. Evidence indicates that this shared partner interacts with the RNF20/40 complex through its C-ter... | |
medium_convergence_00774 | MCM3 and GINS3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In vitro binding assays indicate that MCM3 does not interact directly with Stat1, suggesting that the presence of MCM3 in the group of Stat1TAD-interacting proteins is due to the association... | DNA replication licensing factor MCM5 | Medium | convergence | {"qa_id":"medium_convergence_00774","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM3 and GINS3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In vitro binding assays ind... | |
medium_convergence_00775 | GRB2 and NCK1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We show here that the cytoplasmic domain of the shared entity, metargidin, can interact specifically with Src family protein-tyrosine kinases (PTKs) and the adaptor protein Grb2 in hematopoietic cells (Jurkat, THP... | Disintegrin and metalloproteinase domain-containing protein 15 | Medium | convergence | {"qa_id":"medium_convergence_00775","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and NCK1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We show here that the cytoplasmic domain of the sh... | |
medium_convergence_00776 | WNT5A and WNT2B are both implicated in multiple shared biological processes. One such process is supported by evidence showing that exposure to stromal cell layers expressing Wnt genes significantly increased the numbers of hematopoietic progenitor cells, including mixed colony-forming units (CFU-MIX), CFU-granulocyte ... | hemopoiesis | Medium | convergence | {"qa_id":"medium_convergence_00776","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WNT5A and WNT2B are both implicated in multiple shared biological processes. One such process is supported by evidence showing that exposure to stromal cell ... | |
medium_convergence_00778 | HSP90AA1 and STING1 share common interacting partners. One such shared partner is described in evidence stating: 'Using a mass spectrometric-based approach, we have identified a cohort of chaperones and co-chaperones including Hsp90 and Cdc37, which bind to a specific interleukin-1 receptor-associated kinase but not an... | Interleukin-1 receptor-associated kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_00778","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and STING1 share common interacting partners. One such shared partner is described in evidence stating: 'Using a mass spectrometric-based approach, ... | |
medium_convergence_00779 | FOXP3 and SFTPD are both associated with multiple shared biological processes. One such process is characterized by evidence that ectopic expression of the corresponding regulatory entity in conventional T cells is sufficient to confer suppressive activity, specifically repressing the production of cytokines such as in... | interleukin-2 production | Medium | convergence | {"qa_id":"medium_convergence_00779","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOXP3 and SFTPD are both associated with multiple shared biological processes. One such process is characterized by evidence that ectopic expression of the c... | |
medium_convergence_00780 | HUWE1 and EP300 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We found that p300, a CREB-binding protein-related protein, interacts with this protein both in vitro and in vivo and activates transcription.' Which cellular component is this protein located in? | chromatin | Medium | convergence | {"qa_id":"medium_convergence_00780","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and EP300 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We found that p300, a CREB-binding protein-relat... | |
medium_convergence_00781 | ESR1 and MYC share a common interacting partner. Evidence regarding this shared partner indicates that its interaction with MYC suggests a new mechanism for the regulation of MYC-driven tumors by a chromatin complex involving BRD4. Which biological process is this shared partner involved in? | positive regulation of DNA-templated transcription | Medium | convergence | {"qa_id":"medium_convergence_00781","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and MYC share a common interacting partner. Evidence regarding this shared partner indicates that its interaction with MYC suggests a new mechanism for ... | |
medium_convergence_00783 | ACTB and EPC1 both interact with a common protein partner. Evidence regarding this partner states: 'Finally, analogous to yeast, a recombinant trimeric complex formed by Tip60, EPC1, and this partner is sufficient to reconstitute robust nucleosomal HAT activity in vitro.' Which protein is encoded by the gene correspond... | Inhibitor of growth protein 3 | Medium | convergence | {"qa_id":"medium_convergence_00783","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTB and EPC1 both interact with a common protein partner. Evidence regarding this partner states: 'Finally, analogous to yeast, a recombinant trimeric compl... | |
medium_convergence_00784 | CAND1 and CUL3 each interact with multiple shared partners. One such partner is part of a novel CUL3 RING ubiquitin ligase complex, which also contains another substrate adaptor, and together they mediate the ubiquitylation and proteasomal degradation of TIAM1, a RAC1-specific GEF. Which protein is encoded by this spec... | Kelch repeat and BTB domain-containing protein 6 | Medium | convergence | {"qa_id":"medium_convergence_00784","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL3 each interact with multiple shared partners. One such partner is part of a novel CUL3 RING ubiquitin ligase complex, which also contains anoth... | |
medium_convergence_00785 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of -2.112 and an adjusted p-value of 0.04933. Which protein interacts with this gene product? | PRNP | Medium | convergence | {"qa_id":"medium_convergence_00785","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) ind... | |
medium_convergence_00786 | COMMD1 and CUL5 both interact with a shared protein. Evidence indicates that this shared protein is involved in the formation of a novel E3 ligase through interaction with a CUL5-ELOB/C-RNF7 complex, and that specific deleterious variants affect the binding amount of this protein and CUL5. Which cell type is this share... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_00786","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL5 both interact with a shared protein. Evidence indicates that this shared protein is involved in the formation of a novel E3 ligase through in... | |
medium_convergence_00787 | HSPA8 and TP53 share a common interacting partner. Evidence indicates that this partner phosphorylates human p53 at Thr18 and disrupts the p53-Mdm2 interaction in vitro, although a significant decrease in p53 ubiquitination by Mdm2 in vivo was not detected. Which cell type is enriched for this interacting partner? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_00787","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA8 and TP53 share a common interacting partner. Evidence indicates that this partner phosphorylates human p53 at Thr18 and disrupts the p53-Mdm2 interacti... | |
medium_convergence_00789 | Mefloquine and Cimetidine both interact with a specific shared drug. Evidence regarding this shared drug describes pharmacokinetic interactions between artesunate-mefloquine and ritonavir-boosted versions of this drug in healthy Thai adults. Which disease is this shared drug indicated for? | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_00789","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Mefloquine and Cimetidine both interact with a specific shared drug. Evidence regarding this shared drug describes pharmacokinetic interactions between artes... | |
medium_convergence_00790 | STUB1 and TRIM21 both interact with a specific ubiquitin-conjugating enzyme. Evidence indicates that CHIP acts as a functional partner of Ubc13 and this enzyme in the formation of Lys63-linked polyubiquitin chains, extending CHIP's roles into ubiquitin regulation. Which protein is encoded by the gene corresponding to t... | Ubiquitin-conjugating enzyme E2 variant 1 | Medium | convergence | {"qa_id":"medium_convergence_00790","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and TRIM21 both interact with a specific ubiquitin-conjugating enzyme. Evidence indicates that CHIP acts as a functional partner of Ubc13 and this enzy... | |
medium_convergence_00791 | BIRC3 and ATM both interact with a shared protein. Evidence indicates that cIAP2 (encoded by BIRC3) normally inhibits antigen receptor signaling by mediating the ubiquitination and degradation of this shared entity, which is described as a critical component for antigenic signaling to NF-kappaB. Which protein is encode... | B-cell lymphoma/leukemia 10 | Medium | convergence | {"qa_id":"medium_convergence_00791","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and ATM both interact with a shared protein. Evidence indicates that cIAP2 (encoded by BIRC3) normally inhibits antigen receptor signaling by mediating... | |
medium_convergence_00792 | Both ABL1 and AR interact with a specific shared protein. Contextual evidence regarding this shared entity states: 'Moreover, both Csk and c-Abl were also not defective in binding to these mutants, although Csk and c-Abl were either unable to degrade or increased the steady-state levels of all c-[Entity] mutants respec... | Transcription factor Jun | Medium | convergence | {"qa_id":"medium_convergence_00792","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ABL1 and AR interact with a specific shared protein. Contextual evidence regarding this shared entity states: 'Moreover, both Csk and c-Abl were also no... | |
medium_convergence_00793 | Human gammaherpesvirus 4 and Human immunodeficiency virus 1 both downregulate a specific gene. In a study of gamma delta T-lymphocytes (GSE13906), this gene exhibited a log2 fold change of approximately -1.647 and an adjusted p-value of 0.02096. Which biological process is this gene involved in? | positive regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_00793","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human gammaherpesvirus 4 and Human immunodeficiency virus 1 both downregulate a specific gene. In a study of gamma delta T-lymphocytes (GSE13906), this gene ... | |
medium_convergence_00794 | CENPA and CENPC both interact with a shared protein complex component. Evidence indicates that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (a specific centromere protein, CENP-N and CENP-T), along with CENP-U, CENP-C and CENP... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00794","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPC both interact with a shared protein complex component. Evidence indicates that CENP-A nucleosomes directly recruit a proximal CENP-A nucleoso... | |
medium_convergence_00795 | ANAPC2 and BUB1 both interact with a common protein partner. Evidence indicates that this shared partner specifically recognizes APC substrates involved in the metaphase-to-anaphase transition and plays a pivotal role in APC activation through direct interaction with the APC. Which protein is encoded by this shared par... | Cell division cycle protein 20 homolog | Medium | convergence | {"qa_id":"medium_convergence_00795","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC2 and BUB1 both interact with a common protein partner. Evidence indicates that this shared partner specifically recognizes APC substrates involved in t... | |
medium_convergence_00796 | Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared host gene. Experimental data for this gene indicates a log2 fold change of approximately -1.058 and an adjusted p-value of 0.03401. In which cellular component is the protein product of this gene primarily located? | mitochondrion | Medium | convergence | {"qa_id":"medium_convergence_00796","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared host gene. Experimental data for this gene indicates a log2 fold... | |
medium_convergence_00797 | Both Human betaherpesvirus 5 and Dengue virus are known to downregulate a specific host gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE130665) reports a log2 fold change of approximately -1.200 and an adjusted p-value of 2.879e-06. Which cellular component is this gene located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_00797","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Dengue virus are known to downregulate a specific host gene. Experimental data for this gene in foreskin fibroblast cell lin... | |
medium_convergence_00798 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are reported to upregulate a specific gene. Evidence for this shared target indicates a log2 fold change of approximately 1.21 and an adjusted p-value of 0.038. Which cellular component is this gene located in? | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_00798","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are reported to upregulate a specific gene. Evidence for this shared ta... | |
medium_convergence_00799 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.40 and an adjusted p-value of approximately 0.0019. Which protein is encoded by this gene? | Protein S100-A10 | Medium | convergence | {"qa_id":"medium_convergence_00799","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study G... | |
medium_convergence_00800 | CSNK2B and PCGF6 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Further biochemical dissection revealed that the six PCGF-RING1A/B combinations form multiple complexes through association with this protein or its homolog YAF2, which prevents the incorporation of other c... | RING1 and YY1-binding protein | Medium | convergence | {"qa_id":"medium_convergence_00800","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and PCGF6 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Further biochemical dissection revealed tha... | |
medium_convergence_00802 | USP51 and RNF168 share a common interaction partner. Evidence indicates that radiation-induced ATM-dependent phosphorylation of this shared entity at serine 677 facilitates USP51 to bind, deubiquitinate, and stabilize it, leading to the recruitment of this entity and RNF168 to MDC1 and RNF8 at DNA double-strand breaks.... | Microprocessor complex subunit DGCR8 | Medium | convergence | {"qa_id":"medium_convergence_00802","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"USP51 and RNF168 share a common interaction partner. Evidence indicates that radiation-induced ATM-dependent phosphorylation of this shared entity at serine ... | |
medium_convergence_00803 | FAF2 and UBQLN2 share multiple interacting partners. One such shared partner is experimentally confirmed to interact with FAF2, AUP1, TRIM47, ACSL3, SQSTM1, and PCBP2 via Co-IP and confocal microscopy. Which disease is associated with this specific shared partner through genomic alterations? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_00803","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAF2 and UBQLN2 share multiple interacting partners. One such shared partner is experimentally confirmed to interact with FAF2, AUP1, TRIM47, ACSL3, SQSTM1, ... | |
medium_convergence_00804 | Both Zaire ebolavirus and Zika virus have been shown to downregulate a specific host gene. In a study of retinal pigment epithelium cells (GSE100839), this gene exhibited a log2 fold change of approximately -1.166 and an adjusted p-value of 0.01345. Which biological process is this gene involved in? | sulfate transmembrane transport | Medium | convergence | {"qa_id":"medium_convergence_00804","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Zaire ebolavirus and Zika virus have been shown to downregulate a specific host gene. In a study of retinal pigment epithelium cells (GSE100839), this g... | |
medium_convergence_00805 | TRIM28 and RAC1 share a common interacting partner. Evidence indicates that this shared partner interacts with TRIM28, described as a master regulator of gene expression, within the nucleus of non-small cell lung cancer (NSCLC) cells. Which protein is encoded by this shared interacting partner? | Rho guanine nucleotide exchange factor TIAM1 | Medium | convergence | {"qa_id":"medium_convergence_00805","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and RAC1 share a common interacting partner. Evidence indicates that this shared partner interacts with TRIM28, described as a master regulator of gen... | |
medium_convergence_00806 | DCUN1D3 and CUL1 each interact with more than one shared protein. Experimental evidence indicates that one of these shared proteins forms a complex with recombinant Skp1 and recombinant CUL1 in vitro, even in the absence of recombinant CRY1. Which protein is encoded by the gene corresponding to this shared entity? | F-box/LRR-repeat protein 3 | Medium | convergence | {"qa_id":"medium_convergence_00806","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCUN1D3 and CUL1 each interact with more than one shared protein. Experimental evidence indicates that one of these shared proteins forms a complex with reco... | |
medium_convergence_00807 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.193 and an adjusted p-value of 0.0002079. Which cell type is ... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_00807","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific shared gene. Experimental data f... | |
medium_convergence_00808 | GRB2 and WASL both bind to a shared protein. Evidence regarding this shared entity states: 'Although the WASP homology 1 (WH1) domain of N-WASP interacts directly with [the shared protein], we still lack the exact nature of its binding site.' Which gene does this shared entity interact with? | NCK2 | Medium | convergence | {"qa_id":"medium_convergence_00808","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and WASL both bind to a shared protein. Evidence regarding this shared entity states: 'Although the WASP homology 1 (WH1) domain of N-WASP interacts dir... | |
medium_convergence_00809 | EIF3D and EIF3I share multiple binding partners. One such partner is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein, encoded by the gene corresponding to this specific binding partner, is the target of the 'encodes' relationship? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_00809","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3D and EIF3I share multiple binding partners. One such partner is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 im... | |
medium_convergence_00811 | KRAS and MAPK3 share multiple protein interaction partners. One such shared partner is implicated in a mechanism where Sur-8 interacts with Ras and Raf to form a ternary complex. Which protein, among the shared partners of KRAS and MAPK3, is the one associated with this Sur-8/Ras/Raf interaction context, and what is th... | RAF proto-oncogene serine/threonine-protein kinase | Medium | convergence | {"qa_id":"medium_convergence_00811","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRAS and MAPK3 share multiple protein interaction partners. One such shared partner is implicated in a mechanism where Sur-8 interacts with Ras and Raf to fo... | |
medium_convergence_00812 | MAPK1 and MAPK3 share a common interacting partner. Evidence regarding one such partner states: 'In this report we show that RSK1 and ERK1/2 form a complex in quiescent HEK293 cells that transiently dissociates upon mitogen stimulation.' Identify the gene that interacts with this specific shared partner. | RPS6KA3 | Medium | convergence | {"qa_id":"medium_convergence_00812","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK1 and MAPK3 share a common interacting partner. Evidence regarding one such partner states: 'In this report we show that RSK1 and ERK1/2 form a complex i... | |
medium_convergence_00813 | Rift Valley fever phlebovirus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of approximately 2.79 and an adjusted p-value of approximately 0.0035. Which biological process is this gene involved in? | protein autoubiquitination | Medium | convergence | {"qa_id":"medium_convergence_00813","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a lo... | |
medium_convergence_00814 | CHMP4B and CHMP3 both interact with a specific protein. Experimental evidence from a yeast two-hybrid assay indicates that HD-PTP shows positive interactions with this protein (also known as Shax1), endophilin A1, and ALG-2, but does not interact with RabGAPLP or CIN85. Which disease is associated with this protein? | microcephaly 29, primary, autosomal recessive | Medium | convergence | {"qa_id":"medium_convergence_00814","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and CHMP3 both interact with a specific protein. Experimental evidence from a yeast two-hybrid assay indicates that HD-PTP shows positive interactions... | |
medium_convergence_00815 | EEF1A1 and AKT1 share a common interacting partner. Evidence regarding this shared partner states: 'Immunoprecipitation and glutathione S-transferase (GST) pull-down studies showed that Akt was associated with p38 kinase, MK2, and a heat shock protein in neutrophils, and this heat shock protein dissociated from the com... | Heat shock protein beta-1 | Medium | convergence | {"qa_id":"medium_convergence_00815","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EEF1A1 and AKT1 share a common interacting partner. Evidence regarding this shared partner states: 'Immunoprecipitation and glutathione S-transferase (GST) p... | |
medium_convergence_00816 | CFTR and ADRB2 share a common interacting partner. Experimental evidence indicates that this shared partner binds to the DeltaF508 mutant of CFTR via its CUE (coupling of ubiquitin to ER degradation) domain. Which protein is encoded by this shared interacting partner? | E3 ubiquitin-protein ligase AMFR | Medium | convergence | {"qa_id":"medium_convergence_00816","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFTR and ADRB2 share a common interacting partner. Experimental evidence indicates that this shared partner binds to the DeltaF508 mutant of CFTR via its CUE... | |
medium_convergence_00817 | ERCC4 and CENPS both interact with a common protein partner. Biochemical evidence indicates that MHF1 and MHF2 form a heterodimer that binds DNA and enhances the DNA branch migration activity of this shared partner. Which protein is encoded by the gene corresponding to this shared partner? | Fanconi anemia core complex-associated protein 100 | Medium | convergence | {"qa_id":"medium_convergence_00817","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC4 and CENPS both interact with a common protein partner. Biochemical evidence indicates that MHF1 and MHF2 form a heterodimer that binds DNA and enhances... | |
medium_convergence_00818 | EGR2 and CBX5 both interact with a shared histone variant. Evidence regarding this shared entity states: 'We find that the chromoshadow-domain interacts with histone H3 in a region located partially inside the nucleosomal barrel at the entry/exit point of the nucleosome.' Which disease is associated with this entity vi... | squamous cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00818","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGR2 and CBX5 both interact with a shared histone variant. Evidence regarding this shared entity states: 'We find that the chromoshadow-domain interacts with... | |
medium_convergence_00819 | HOXB9 and SKP2 both interact with a specific shared protein. Evidence regarding this interaction states: 'Here we report the physical and functional association between these proteins and the homeodomain protein Hoxb9.' Which protein is encoded by the gene corresponding to this shared interacting partner? | Protein BTG2 | Medium | convergence | {"qa_id":"medium_convergence_00819","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HOXB9 and SKP2 both interact with a specific shared protein. Evidence regarding this interaction states: 'Here we report the physical and functional associat... | |
medium_convergence_00820 | DIS3 and DCP1A both interact with a shared protein component of the human exosome core. Evidence indicates that the homologs hDIS3 and hDIS3L are associated with this complex. Which protein, encoded by the gene corresponding to this shared component, is the target of the 'encodes' relationship? | Exosome complex component RRP4 | Medium | convergence | {"qa_id":"medium_convergence_00820","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIS3 and DCP1A both interact with a shared protein component of the human exosome core. Evidence indicates that the homologs hDIS3 and hDIS3L are associated ... | |
medium_convergence_00821 | PSMA8 and POMP both interact with a common protein partner. Evidence indicates that proteassemblin interacts with beta5, but not beta5i, suggesting a role in the propeptide-dependent differential incorporation of these subunits. Which protein is encoded by the gene corresponding to this shared partner? | Proteasome subunit beta type-5 | Medium | convergence | {"qa_id":"medium_convergence_00821","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA8 and POMP both interact with a common protein partner. Evidence indicates that proteassemblin interacts with beta5, but not beta5i, suggesting a role in... | |
medium_convergence_00822 | CDK2 and DDB1 share multiple interacting partners. One such shared partner is characterized by evidence stating: 'Further analysis reveals that this protein interacts with cyclin/cyclin-dependent kinase (Cdk) complexes through a cyclin/Cdk binding consensus site, located at the N terminus of this protein.' Which protei... | DNA replication factor Cdt1 | Medium | convergence | {"qa_id":"medium_convergence_00822","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and DDB1 share multiple interacting partners. One such shared partner is characterized by evidence stating: 'Further analysis reveals that this protein ... | |
medium_convergence_00823 | SOX2 and TP53 share a common interacting partner. Evidence indicates that this partner forms a complex with BRG1 that interacts directly with p53, and that mutations in this partner's gene and TP53 are mutually exclusive in tumor specimens. Which disease is associated with this entity as a biomarker? | Burkitt lymphoma | Medium | convergence | {"qa_id":"medium_convergence_00823","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SOX2 and TP53 share a common interacting partner. Evidence indicates that this partner forms a complex with BRG1 that interacts directly with p53, and that m... | |
medium_convergence_00824 | TRIM28 and PRDX4 both interact with a specific shared protein. Experimental evidence indicates that TIF1beta (encoded by TRIM28) interacts directly with NGFI-B and other Nur family members. Which protein product is encoded by this shared interacting partner? | Nuclear receptor subfamily 4immunitygroup A member 1 | Medium | convergence | {"qa_id":"medium_convergence_00824","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and PRDX4 both interact with a specific shared protein. Experimental evidence indicates that TIF1beta (encoded by TRIM28) interacts directly with NGFI... | |
medium_convergence_00825 | CTNNA1 and DAG1 both interact with a shared protein. Evidence regarding this shared protein states: 'We therefore propose that cadherin/catenin complexes are linked to the actin cytoskeleton via a direct association between alpha-actinin and alpha-catenin.' Which cell type is this shared protein enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_00825","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNA1 and DAG1 both interact with a shared protein. Evidence regarding this shared protein states: 'We therefore propose that cadherin/catenin complexes are... | |
medium_convergence_00826 | HBEGF and ERBB3 share multiple binding partners. One such partner is described by the evidence: 'Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases.' Which disease is associated with this specific shared partner? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00826","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HBEGF and ERBB3 share multiple binding partners. One such partner is described by the evidence: 'Like NRG-1, the EGF-like domain of the new ligands binds to ... | |
medium_convergence_00827 | LEFTY2 and ACVR1B both interact with a common protein partner. Experimental evidence indicates that this partner, identified as a specific Nodal co-receptor, binds to cell surface ALK4 on mammalian epithelial cells, as demonstrated by fluorescence-activated cell sorter analysis and coimmunoprecipitation. Which protein ... | Protein Cripto | Medium | convergence | {"qa_id":"medium_convergence_00827","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LEFTY2 and ACVR1B both interact with a common protein partner. Experimental evidence indicates that this partner, identified as a specific Nodal co-receptor,... | |
medium_convergence_00828 | ARRB1 and ARRB2 each interact with multiple shared partners. One such partner is described in evidence stating: 'Our data demonstrate that β-arrestin 1 and β-arrestin 2 bind constitutively to the most common dopamine D4 receptor polymorphic variants and to KLHL12 and that all three proteins can interact within a single... | D(4) dopamine receptor | Medium | convergence | {"qa_id":"medium_convergence_00828","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARRB1 and ARRB2 each interact with multiple shared partners. One such partner is described in evidence stating: 'Our data demonstrate that β-arrestin 1 and β... | |
medium_convergence_00829 | Human respirovirus 3 and Human immunodeficiency virus 1 both upregulate a specific gene. In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), this gene showed a log2 fold change of 1.223 and an adjusted p-value of 0.04216. Which protein is encoded by this gene? | Interferon-induced transmembrane protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00829","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Human immunodeficiency virus 1 both upregulate a specific gene. In a study of non-small cell lung adenocarcinoma cell lines (GSE1475... | |
medium_convergence_00830 | BRD8 and EP400 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Yeast two-hybrid screening and subsequent immunoprecipitation analysis identified bromodomain containing 8 (BRD8) as an [entity]-interacting protein.' Which protein is encoded by that entity? | MRG/MORF4L-binding protein | Medium | convergence | {"qa_id":"medium_convergence_00830","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD8 and EP400 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Yeast two-hybrid screening and subsequent imm... | |
medium_convergence_00831 | COL1A1 and ACTB share common binding partners. One such partner is associated with evidence stating: 'Cultured cells synthesized proalpha2(I) chains that were slow to assemble with proalpha1(I) chains to form heterotrimers and that were retained intracellularly.' Which protein encodes the entity described in this evide... | Collagen alpha-2(I) chain | Medium | convergence | {"qa_id":"medium_convergence_00831","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COL1A1 and ACTB share common binding partners. One such partner is associated with evidence stating: 'Cultured cells synthesized proalpha2(I) chains that wer... | |
medium_convergence_00832 | GNA15 and GNB4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In vitro translation co-precipitation analyses revealed that Gbeta4 can form stable dimers with Ggamma1, Ggamma2, Ggamma3, Ggamma4, Ggamma5, Ggamma7, Ggamma10, Ggamma11, Ggamma12, and Ggamma... | extracellular exosome | Medium | convergence | {"qa_id":"medium_convergence_00832","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA15 and GNB4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In vitro translation co-pre... | |
medium_convergence_00833 | The intervertebral disk of the sacral vertebra and the sacral vertebra endochondral element are both anatomical structures located within the pelvic region. Evidence indicates that an intervertebral disk in the sacral region connects sacral vertebrae. Given this anatomical localization, which broader anatomical categor... | abdominal segment element | Medium | convergence | {"qa_id":"medium_convergence_00833","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The intervertebral disk of the sacral vertebra and the sacral vertebra endochondral element are both anatomical structures located within the pelvic region. ... | |
medium_convergence_00834 | Etanercept and Morphine share interactions with multiple drugs. One such shared drug is an L-type dihydropyridine calcium channel blocker with relatively high blood-brain barrier penetration, for which experimental evidence indicates it enhances the antinociceptive properties of Morphine. Which disease is this specific... | subarachnoid hemorrhage | Medium | convergence | {"qa_id":"medium_convergence_00834","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Etanercept and Morphine share interactions with multiple drugs. One such shared drug is an L-type dihydropyridine calcium channel blocker with relatively hig... | |
medium_convergence_00838 | BEX3 and IKBKB each interact with more than one shared gene. Evidence concerning one shared entity reports that Aβ significantly reduced NF-κB activity by attenuating the interaction of p75(NTR) with IKKβ. Which disease is connected to that entity through a causal relationship? | brain neoplasm | Medium | convergence | {"qa_id":"medium_convergence_00838","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BEX3 and IKBKB each interact with more than one shared gene. Evidence concerning one shared entity reports that Aβ significantly reduced NF-κB activity by at... | |
medium_convergence_00839 | FGFR1 and RHOB share a common interacting partner. Experimental evidence indicates that a specific tyrosine kinase directly associates with FGFR-1beta via co-immunoprecipitation. Which protein is encoded by this shared interacting partner? | Tyrosine-protein kinase Yes | Medium | convergence | {"qa_id":"medium_convergence_00839","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGFR1 and RHOB share a common interacting partner. Experimental evidence indicates that a specific tyrosine kinase directly associates with FGFR-1beta via co... | |
medium_convergence_00841 | KDM1A and HDAC1 both interact with a shared protein partner. Evidence indicates that a transcriptional co-repressor complex containing LSD1, this shared partner, and HDAC1 (termed LCH) represses transcription by coordinately removing histone modifications associated with transcriptional activation. Which protein is enc... | REST corepressor 1 | Medium | convergence | {"qa_id":"medium_convergence_00841","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KDM1A and HDAC1 both interact with a shared protein partner. Evidence indicates that a transcriptional co-repressor complex containing LSD1, this shared part... | |
medium_convergence_00842 | Influenza A virus and Pegivirus C both upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line shows a log2 fold change of approximately 1.087 and an adjusted p-value of 0.01159. Which cellular component is this gene located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00842","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Influenza A virus and Pegivirus C both upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line shows a ... | |
medium_convergence_00843 | MYC and HIST1H3A share multiple interacting partners. One such shared partner is characterized by evidence stating: 'In this study, we characterized the chromatin association of this protein and found that it preferentially binds histone H3/H4 via its C-terminal NAP-like domain both in vitro and ex vivo.' Which protein... | Testis-specific Y-encoded-like protein 5 | Medium | convergence | {"qa_id":"medium_convergence_00843","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and HIST1H3A share multiple interacting partners. One such shared partner is characterized by evidence stating: 'In this study, we characterized the chro... | |
medium_convergence_00844 | Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.235 and an adjusted p-value of 0.0001682. Which protein does this gene product interact with? | ITCH | Medium | convergence | {"qa_id":"medium_convergence_00844","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports... | |
medium_convergence_00846 | PCNA and NPLOC4 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'The only functional data available about mammalian Ufd1p is the ability to form a complex with the rat Npl4 protein, a component of the nuclear pore complex.' Which protein is encoded by the gene correspondi... | Ubiquitin recognition factor in ER-associated degradation protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00846","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCNA and NPLOC4 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'The only functional data available about mam... | |
medium_convergence_00847 | CDC7 and CDC6 both interact with a specific shared protein. Experimental evidence indicates that after reoxygenation, this shared protein undergoes significant phosphorylation and shows increased coimmunoprecipitation with CDC7, which acts as its kinase. Which disease is associated with this shared protein? | autosomal dominant nonsyndromic hearing loss 70 | Medium | convergence | {"qa_id":"medium_convergence_00847","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC7 and CDC6 both interact with a specific shared protein. Experimental evidence indicates that after reoxygenation, this shared protein undergoes significa... | |
medium_convergence_00848 | RBCK1 and RNF31 both interact with a shared protein partner. Evidence regarding one such partner states: 'We identified an unexpected interaction between the E2 [partner] and the E3 RNF31 (HOIP), the catalytic subunit of the LUBAC complex.' Which protein is encoded by this shared partner? | Ubiquitin-conjugating enzyme E2 L3 | Medium | convergence | {"qa_id":"medium_convergence_00848","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBCK1 and RNF31 both interact with a shared protein partner. Evidence regarding one such partner states: 'We identified an unexpected interaction between the... | |
medium_convergence_00849 | UBR5 and BRCA1 both interact with a shared protein entity. Evidence indicates that this entity interacts with gamma-tubulin, as demonstrated by in vitro translation studies showing full-length protein interaction. Which cell type is this entity enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_00849","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBR5 and BRCA1 both interact with a shared protein entity. Evidence indicates that this entity interacts with gamma-tubulin, as demonstrated by in vitro tran... | |
medium_convergence_00851 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of 1.849 and an adjusted p-value of 0.01213. Which cellular component is this gene located in? | chromosome, telomeric region | Medium | convergence | {"qa_id":"medium_convergence_00851","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a... | |
medium_convergence_00853 | CREBBP and FBXW7 both interact with a specific gene product. Evidence regarding this shared entity states: 'In an unbiased search for potential coactivators of SREBP, we isolated a protein of 265 kD from HeLa cells that directly bound SREBP-1 and SREBP-2.' Which protein is encoded by this shared gene? | Sterol regulatory element-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00853","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and FBXW7 both interact with a specific gene product. Evidence regarding this shared entity states: 'In an unbiased search for potential coactivators ... | |
medium_convergence_00854 | PARP2 and BRD4 both interact with a specific shared protein. Experimental evidence indicates that this shared protein interacts significantly with the transition protein TP2 and acts as a transition chaperone, whereas PARP1 binds to it only weakly. Which protein is encoded by the gene corresponding to this shared entit... | Heat shock-related 70 kDa protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00854","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP2 and BRD4 both interact with a specific shared protein. Experimental evidence indicates that this shared protein interacts significantly with the transi... | |
medium_convergence_00855 | Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of approximately 2.59 and an adjusted p-value of 0.0307. In which cellular component is this gene product located? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00855","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data for this gene reports a log2 f... | |
medium_convergence_00856 | BMP2 and ACVR2B both interact with a shared downstream signaling component. Evidence regarding this component states: 'We have used BMP-2 as a key representative of the BMPs to identify the epitopes for type I and type II receptor binding by mutational interaction analyses and have solved the crystal structure of a BMP... | Bone morphogenetic protein receptor type-1A | Medium | convergence | {"qa_id":"medium_convergence_00856","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP2 and ACVR2B both interact with a shared downstream signaling component. Evidence regarding this component states: 'We have used BMP-2 as a key representa... | |
medium_convergence_00857 | DYNLL2 and DBN1 share a common interacting partner. Evidence indicates that in healthy cells, the protein Bmf is sequestered to myosin V motors through its association with dynein light chain 2 (DYNLL2). Which cell type is enriched for this shared interacting partner? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_00857","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DYNLL2 and DBN1 share a common interacting partner. Evidence indicates that in healthy cells, the protein Bmf is sequestered to myosin V motors through its a... | |
medium_convergence_00858 | CNOT6L and PABPC1 share a common interaction partner. Experimental evidence confirms that this shared partner interacts with CIN85, cytoplasmic poly(A) binding protein (PABP), nucleolin, and heat shock protein 70 via co-immunoprecipitation. Which protein is encoded by this shared interaction partner? | mRNA decay activator protein ZFP36 | Medium | convergence | {"qa_id":"medium_convergence_00858","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNOT6L and PABPC1 share a common interaction partner. Experimental evidence confirms that this shared partner interacts with CIN85, cytoplasmic poly(A) bindi... | |
medium_convergence_00860 | EIF1AX and EIF3J share multiple binding partners. One shared partner is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which cellular component is this specific shared partner located in? | eukaryotic translation initiation factor 3 complex | Medium | convergence | {"qa_id":"medium_convergence_00860","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF1AX and EIF3J share multiple binding partners. One shared partner is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1... | |
medium_convergence_00861 | YWHAQ and SFN share a common interaction partner. Experimental evidence indicates that this shared partner binds to SFN in vitro and co-localizes with it at early endosomes in lung adenocarcinoma cells. Which disease is associated with this shared partner through genomic alterations? | ACTH-dependent Cushing syndrome | Medium | convergence | {"qa_id":"medium_convergence_00861","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and SFN share a common interaction partner. Experimental evidence indicates that this shared partner binds to SFN in vitro and co-localizes with it at ... | |
medium_convergence_00862 | ELAVL1 and PRKN share multiple interacting partners. One such shared partner is described by the following evidence: 'Moreover, Parkin interacts with and ubiquitinates a specific protein facilitating its degradation through the ubiquitin proteasome system.' Which cellular component is this specific shared partner locat... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00862","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ELAVL1 and PRKN share multiple interacting partners. One such shared partner is described by the following evidence: 'Moreover, Parkin interacts with and ubi... | |
medium_convergence_00863 | Succinylcholine and Cisatracurium both interact with a specific drug. Clinical evidence regarding this drug states: 'No patient in the magnesium group had an increase in serum potassium (mean change -0.05 +/- 0.02 mmol/L). The difference between the groups was statistically significant (P less than 0.01).' Which diseas... | eclampsia | Medium | convergence | {"qa_id":"medium_convergence_00863","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Succinylcholine and Cisatracurium both interact with a specific drug. Clinical evidence regarding this drug states: 'No patient in the magnesium group had an... | |
medium_convergence_00864 | LGR4 and LGR6 both interact with a specific protein. Mechanistic evidence indicates that R-spondin interacts with the extracellular domain of this protein and induces its association with LGR4, resulting in the membrane clearance of this protein. Which disease is associated with this protein through genomic alterations... | primary angle-closure glaucoma | Medium | convergence | {"qa_id":"medium_convergence_00864","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LGR4 and LGR6 both interact with a specific protein. Mechanistic evidence indicates that R-spondin interacts with the extracellular domain of this protein an... | |
medium_convergence_00865 | KCNA5 and SCN5A are both associated with multiple shared biological processes. One specific shared process is linked to evidence stating: 'In human heart, the Shaker-related voltage-gated K(+) channel KCNA5 alpha-subunit forms the major basis of an atrial-specific, ultra-rapid delayed rectifier K(+) current, I(Kur).' W... | cardiac muscle cell action potential involved in contraction | Medium | convergence | {"qa_id":"medium_convergence_00865","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNA5 and SCN5A are both associated with multiple shared biological processes. One specific shared process is linked to evidence stating: 'In human heart, th... |
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