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medium_convergence_05753 | BUB1B and AURKB each interact with more than one shared protein. Evidence concerning one shared entity states: 'We call this factor the mitotic checkpoint complex (MCC) as it consists of hBUBR1, hBUB3, CDC20, and MAD2 checkpoint proteins in near equal stoichiometry.' Which cellular component is connected to that entity... | kinetochore | Medium | convergence | {"qa_id":"medium_convergence_05753","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BUB1B and AURKB each interact with more than one shared protein. Evidence concerning one shared entity states: 'We call this factor the mitotic checkpoint co... | |
medium_convergence_05755 | Morphine and Omeprazole both interact with a specific drug. Evidence regarding this drug notes that five cases were caused by interactions between it and other antiepileptic drugs, etravirine-based antiretroviral therapy, the drug itself, or meropenem. Which disease is this drug indicated for? | epilepsy | Medium | convergence | {"qa_id":"medium_convergence_05755","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Omeprazole both interact with a specific drug. Evidence regarding this drug notes that five cases were caused by interactions between it and oth... | |
medium_convergence_05756 | RAD51C and BRIP1 both interact with a shared protein partner. Experimental evidence indicates that this partner is a core component of a large protein complex (often defined as BCDX2) that includes RAD51B, RAD51D, and XRCC3, as demonstrated by immunoprecipitation studies. Which protein is encoded by the gene correspond... | DNA repair protein XRCC2 | Medium | convergence | {"qa_id":"medium_convergence_05756","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51C and BRIP1 both interact with a shared protein partner. Experimental evidence indicates that this partner is a core component of a large protein comple... | |
medium_convergence_05757 | BLM and BABAM2 each interact with more than one shared protein. Evidence concerning one shared entity reports that interaction between polyubiquitylated BLM and the protein product of NBN is essential for the helicase to be retained at the DSBs. Which cell type is that shared entity enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_05757","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BLM and BABAM2 each interact with more than one shared protein. Evidence concerning one shared entity reports that interaction between polyubiquitylated BLM ... | |
medium_convergence_05758 | EP300 and NCOR1 both interact with a shared nuclear receptor. Evidence indicates that this receptor interacts with corepressors N-CoR and SMRT, which are released upon agonist binding. Which disease is associated with this receptor through genomic alterations? | oral cavity cancer | Medium | convergence | {"qa_id":"medium_convergence_05758","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and NCOR1 both interact with a shared nuclear receptor. Evidence indicates that this receptor interacts with corepressors N-CoR and SMRT, which are rel... | |
medium_convergence_05759 | Both Human immunodeficiency virus 1 and Zaire ebolavirus downregulate a specific gene. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.392 and an adjusted p-value of 0.03696. Which disease is associated with this gene? | severe intellectual disability-corpus callosum agenesis-facial dysmorphism-cerebellar ataxia syndrome | Medium | convergence | {"qa_id":"medium_convergence_05759","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Zaire ebolavirus downregulate a specific gene. In a study of macrophages (GSE108897), this gene exhibited a log2 fold... | |
medium_convergence_05760 | DUSP10 and BOC both interact with a specific protein kinase. Evidence indicates that the dual-specificity phosphatase MKP-5 binds to and inactivates a specific MAPK family member and SAPK/JNK, but does not bind to or inactivate MAPK/ERK. Given that MKP-5 is an alias for DUSP10, which protein kinase, known to be a targe... | Mitogen-activated protein kinase 14 | Medium | convergence | {"qa_id":"medium_convergence_05760","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DUSP10 and BOC both interact with a specific protein kinase. Evidence indicates that the dual-specificity phosphatase MKP-5 binds to and inactivates a specif... | |
medium_convergence_05761 | MAPT and TNF are both associated with multiple shared biological processes. One such shared process involves an entity implicated in neurological disorders that plays a key role in the activation of microglia and astrocytes. Which cell type serves as the primary input for this specific biological process? | astrocyte | Medium | convergence | {"qa_id":"medium_convergence_05761","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPT and TNF are both associated with multiple shared biological processes. One such shared process involves an entity implicated in neurological disorders t... | |
medium_convergence_05762 | BIRC2 and IKBKE each interact with more than one shared gene. Evidence concerning one shared entity reports that the protein encoded by TNFAIP3 directly binds to cIAP1 through the seventh zinc finger of the protein encoded by TNFAIP3, resulting in dissociation of the TRAF2/TRAF3 interaction, thereby inactivating the li... | myocarditis | Medium | convergence | {"qa_id":"medium_convergence_05762","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and IKBKE each interact with more than one shared gene. Evidence concerning one shared entity reports that the protein encoded by TNFAIP3 directly bind... | |
medium_convergence_05763 | BRAP and KSR1 share common binding partners. One such shared partner is described in evidence stating that C-TAK1 constitutively associates with this entity and phosphorylates serine 392 to confer 14-3-3 binding and cytoplasmic sequestration of the entity in unstimulated cells. Which protein is encoded by this shared p... | MAP/microtubule affinity-regulating kinase 3 | Medium | convergence | {"qa_id":"medium_convergence_05763","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRAP and KSR1 share common binding partners. One such shared partner is described in evidence stating that C-TAK1 constitutively associates with this entity ... | |
medium_convergence_05764 | Vaccinia virus and Measles morbillivirus both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of approximately -1.501 and an adjusted p-value of 0.03128. Which protein is encoded by this gene? | Uronyl 2-sulfotransferase | Medium | convergence | {"qa_id":"medium_convergence_05764","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Measles morbillivirus both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibi... | |
medium_convergence_05765 | EP300 and IRF8 share a common interacting partner. Evidence regarding one such partner states: 'Here we investigate the mechanism by which IRF-1 and p53 synergize at the p21 promoter and show that stimulation of p21 transcription by IRF-1 does not require its DNA-binding activity but relies on the ability of IRF-1 to b... | Interferon regulatory factor 1 | Medium | convergence | {"qa_id":"medium_convergence_05765","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and IRF8 share a common interacting partner. Evidence regarding one such partner states: 'Here we investigate the mechanism by which IRF-1 and p53 syne... | |
medium_convergence_05767 | ANLN and PTEN share multiple interacting partners. One such shared partner has an interaction with PTEN that was confirmed by co-immunoprecipitation in transfected mammalian cells. Which protein is encoded by this shared partner? | Major vault protein | Medium | convergence | {"qa_id":"medium_convergence_05767","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANLN and PTEN share multiple interacting partners. One such shared partner has an interaction with PTEN that was confirmed by co-immunoprecipitation in trans... | |
medium_convergence_05768 | FANCD2 and FANCE each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'The human protein reportedly functions as a molecular adaptor within the FA nuclear complex, bridging between the subcomplexes A:G and C:E.' Which disease is connected to that entity through genom... | Fanconi anemia | Medium | convergence | {"qa_id":"medium_convergence_05768","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCD2 and FANCE each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'The human protein reportedly func... | |
medium_convergence_05769 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 1.669 and an adjusted p-value of 0.003917. Which protein is encoded by this gene? | EMILIN-2 | Medium | convergence | {"qa_id":"medium_convergence_05769","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) rep... | |
medium_convergence_05771 | FANCC and FANCB each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here, we demonstrate the ability of FANCE to mediate the interaction between FANCC and this partner in the yeast three-hybrid system and confirm the FANCE-mediated association of FANCC with this... | childhood leukemia | Medium | convergence | {"qa_id":"medium_convergence_05771","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCC and FANCB each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here, we demonstrate the abilit... | |
medium_convergence_05772 | ACTB and CUL3 both interact with a shared protein. Evidence indicates that while the wild-type form of this protein (referred to as NRP/B) associates with actin, mutations in its Kelch domains reduce its binding affinity to actin. Which protein is encoded by this shared entity? | Ectoderm-neural cortex protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05772","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTB and CUL3 both interact with a shared protein. Evidence indicates that while the wild-type form of this protein (referred to as NRP/B) associates with ac... | |
medium_convergence_05773 | CYLD and IFIH1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here, we show that Optineurin (Optn) dampens the antiviral innate immune response by targeting the deubiquitinating enzyme CYLD to this protein in order to inhibit its enzymatic activity.' Which ... | myelofibrosis | Medium | convergence | {"qa_id":"medium_convergence_05773","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CYLD and IFIH1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here, we show that Optineurin (O... | |
medium_convergence_05774 | NUB1 and PSMA6 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'A yeast two-hybrid screen identified NEDD8 ultimate buster-1L as a non-covalent binding partner of a ubiquitin-like modifier, and this interaction was confirmed by coimmunoprecipitation and glutathione S-tran... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_05774","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUB1 and PSMA6 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'A yeast two-hybrid screen identified NEDD8 ul... | |
medium_convergence_05775 | HDAC6 and FGF1 both interact with a specific shared protein. Evidence indicates that this shared protein is a direct binding partner of HDAC6 that regulates the formation of aggresome-like bodies (ALBs) containing NEDDylated cytosolic protein aggregates during ubiquitin stress. Which protein is encoded by the gene corr... | Ubiquitin-like protein NEDD8 | Medium | convergence | {"qa_id":"medium_convergence_05775","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and FGF1 both interact with a specific shared protein. Evidence indicates that this shared protein is a direct binding partner of HDAC6 that regulates ... | |
medium_convergence_05776 | The facial vein and the conjunctival vein share a common anatomical classification. Evidence regarding one of these shared categories describes an entity that commences at the side of the root of the nose as a direct continuation of the angular vein, receiving a small nasal branch. This entity lies behind the facial ar... | blood vessel | Medium | convergence | {"qa_id":"medium_convergence_05776","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The facial vein and the conjunctival vein share a common anatomical classification. Evidence regarding one of these shared categories describes an entity tha... | |
medium_convergence_05777 | KHDRBS1 and RHOA both interact with a shared protein. Evidence indicates that Sam68 associates with p120GAP and PLC gamma 1 in human mature T cells and in the HUT78 CD4+ T cell line. Which protein is encoded by this shared entity? | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Medium | convergence | {"qa_id":"medium_convergence_05777","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KHDRBS1 and RHOA both interact with a shared protein. Evidence indicates that Sam68 associates with p120GAP and PLC gamma 1 in human mature T cells and in th... | |
medium_convergence_05778 | ERBB3 and NRG2 share a common interacting partner. Evidence regarding this partner states: 'In a screen for proteins that might regulate the trafficking or localization of the ErbB3 receptor, we have identified a tripartite or RBCC (RING, B-box, coiled-coil) protein that interacts with the cytoplasmic tail of the recep... | E3 ubiquitin-protein ligase NRDP1 | Medium | convergence | {"qa_id":"medium_convergence_05778","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB3 and NRG2 share a common interacting partner. Evidence regarding this partner states: 'In a screen for proteins that might regulate the trafficking or l... | |
medium_convergence_05779 | IL23R and CARD9 are both involved in more than one shared biological process. Contextual evidence indicates that IL-23, an IL-12p40/p19 heterodimeric protein, binds to IL-12Rbeta1/IL-23R receptor complexes. Which of the shared biological processes is defined as positively regulating a specific downstream immune respons... | T-helper 17 type immune response | Medium | convergence | {"qa_id":"medium_convergence_05779","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL23R and CARD9 are both involved in more than one shared biological process. Contextual evidence indicates that IL-23, an IL-12p40/p19 heterodimeric protein... | |
medium_convergence_05780 | UBQLN1 and PSEN1 both interact with a specific proteasome subunit. Experimental evidence demonstrates a direct physical interaction between this subunit and two other subunits, HC5 and the alpha-5 subunit, of the 20S proteasome. Which protein is encoded by the gene corresponding to this interacting subunit? | Proteasome subunit alpha type-5 | Medium | convergence | {"qa_id":"medium_convergence_05780","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBQLN1 and PSEN1 both interact with a specific proteasome subunit. Experimental evidence demonstrates a direct physical interaction between this subunit and ... | |
medium_convergence_05781 | Human alphaherpesvirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 4.081 and an adjusted p-value of 0.002963. Which protein is encoded by this gene? | Cell division control protein 6 homolog | Medium | convergence | {"qa_id":"medium_convergence_05781","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) ... | |
medium_convergence_05784 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. Experimental data for this gene shows a log2 fold change of 2.339 and an adjusted p-value of 0.02477. Which cellular component is this gene located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_05784","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. Experimental data for this gene shows a log2 fold change of 2.339 and ... | |
medium_convergence_05785 | EP300 and JAK3 share multiple interacting partners. One such partner is described in evidence stating: 'We show that the interaction between E2 and hNAP-1 is direct and not merely mediated by the transcriptional coactivator p300, which is bound by both proteins.' Which disease is associated with this specific shared pa... | depressive disorder | Medium | convergence | {"qa_id":"medium_convergence_05785","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and JAK3 share multiple interacting partners. One such partner is described in evidence stating: 'We show that the interaction between E2 and hNAP-1 is... | |
medium_convergence_05786 | FZR1 and SKP1 both interact with a specific shared protein. Evidence indicates that beta-TrCP is the F-box protein that targets phosphorylated forms of this shared protein for degradation by the Skp1/Cul1/F-box protein complex. Which protein is encoded by the gene corresponding to this shared entity? | M-phase inducer phosphatase 1 | Medium | convergence | {"qa_id":"medium_convergence_05786","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FZR1 and SKP1 both interact with a specific shared protein. Evidence indicates that beta-TrCP is the F-box protein that targets phosphorylated forms of this ... | |
medium_convergence_05787 | CENPA and CENPI each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we show that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (a shared protein, CENP-N and CENP-T), along with... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_05787","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPI each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we show that CENP-A nucleosomes direct... | |
medium_convergence_05788 | EP300 and FOSB both interact with a shared protein partner. Experimental evidence indicates that Immunoprecipitation and chromatin immunoprecipitation analysis demonstrate the interaction of this shared entity and p300 in vivo. Which protein is encoded by this shared entity? | Transcription factor JunB | Medium | convergence | {"qa_id":"medium_convergence_05788","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and FOSB both interact with a shared protein partner. Experimental evidence indicates that Immunoprecipitation and chromatin immunoprecipitation analys... | |
medium_convergence_05789 | TAB1 and ALPK1 both interact with a specific shared protein. Evidence regarding this shared protein describes two distinct complexes: one comprising TAK1, TAB2, and the shared protein, and the other comprising TAK1, TAB1, and the shared protein. Which protein is encoded by the gene corresponding to this shared entity? | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | Medium | convergence | {"qa_id":"medium_convergence_05789","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TAB1 and ALPK1 both interact with a specific shared protein. Evidence regarding this shared protein describes two distinct complexes: one comprising TAK1, TA... | |
medium_convergence_05790 | Both AURKA and AURKB share binding partners. One shared partner is implicated in a context where Aurora-B interacts with the APC/C complex through this specific subunit, leading to Aurora-B ubiquitination and increased protein levels upon proteasome inhibition. Which gene does this specific shared partner interact with... | CDH1 | Medium | convergence | {"qa_id":"medium_convergence_05790","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both AURKA and AURKB share binding partners. One shared partner is implicated in a context where Aurora-B interacts with the APC/C complex through this speci... | |
medium_convergence_05791 | MIR448 and NR4A3 are both involved in multiple shared biological processes. One shared process is supported by evidence that overexpression of miR-448 promoted vascular smooth muscle cell (VSMC) migration. Which biological process, connected to this shared entity via a 'positively regulates' relationship, corresponds t... | vascular associated smooth muscle cell migration | Medium | convergence | {"qa_id":"medium_convergence_05791","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIR448 and NR4A3 are both involved in multiple shared biological processes. One shared process is supported by evidence that overexpression of miR-448 promot... | |
medium_convergence_05792 | Both Influenza A virus and Dengue virus are known to downregulate a specific gene. Experimental data from a study on neutrophils (GSE100865) indicates that this gene exhibits a log2 fold change of approximately -1.007 and an adjusted p-value of 0.006134. Which disease is associated with this gene via genomic alteration... | acute promyelocytic leukemia | Medium | convergence | {"qa_id":"medium_convergence_05792","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Dengue virus are known to downregulate a specific gene. Experimental data from a study on neutrophils (GSE100865) indicates that t... | |
medium_convergence_05793 | CARD11 and BCL10 both interact with a specific shared protein. Experimental evidence indicates that PKCδ inhibits the interaction between this shared protein and TRAF6, but does not inhibit the association of CARMA1 with PKCθ, BCL10, or this shared protein. Which disease is associated with this shared protein via a bio... | aneuploidy | Medium | convergence | {"qa_id":"medium_convergence_05793","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CARD11 and BCL10 both interact with a specific shared protein. Experimental evidence indicates that PKCδ inhibits the interaction between this shared protein... | |
medium_convergence_05794 | Both Influenza A virus and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene reports a log2 fold change of -1.642 and an adjusted p-value of 0.003734. Which protein is encoded by this gene? | Adenylate kinase isoenzyme 5 | Medium | convergence | {"qa_id":"medium_convergence_05794","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene reports a log2 fold change... | |
medium_convergence_05795 | Clemastine and Cyproheptadine both interact with a specific shared drug. Evidence indicates that the anticataleptic effect of two antiparkinsonian drugs, L-DOPA or this shared entity, was potentiated by Cyproheptadine. Which disease is this shared entity indicated for? | swine influenza | Medium | convergence | {"qa_id":"medium_convergence_05795","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Clemastine and Cyproheptadine both interact with a specific shared drug. Evidence indicates that the anticataleptic effect of two antiparkinsonian drugs, L-D... | |
medium_convergence_05796 | COPS5 and MYC both interact with a shared protein. Evidence indicates that this shared protein physically interacts with Jab1 (c-jun activation-domain binding protein 1), a finding confirmed by coimmunoprecipitation in breast cancer cells. Which protein is encoded by the gene corresponding to this shared entity? | Protein S100-A7 | Medium | convergence | {"qa_id":"medium_convergence_05796","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and MYC both interact with a shared protein. Evidence indicates that this shared protein physically interacts with Jab1 (c-jun activation-domain bindin... | |
medium_convergence_05797 | CHAF1A and TLK2 both interact with a shared protein entity. Experimental evidence indicates that hAsf1 proteins interact directly with the p60 subunit of hCAF-1. Which protein is encoded by this shared entity? | Histone chaperone ASF1A | Medium | convergence | {"qa_id":"medium_convergence_05797","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHAF1A and TLK2 both interact with a shared protein entity. Experimental evidence indicates that hAsf1 proteins interact directly with the p60 subunit of hCA... | |
medium_convergence_05798 | HDAC1 and HDAC8 both interact with a specific transcriptional corepressor. Evidence indicates that interactions between Groucho and this corepressor are enhanced by the sumoylation of Groucho, a process mediated by the SUMO-interaction motif of the corepressor. Which disease is associated with this corepressor? | fibrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_05798","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HDAC8 both interact with a specific transcriptional corepressor. Evidence indicates that interactions between Groucho and this corepressor are enha... | |
medium_convergence_05799 | Both ABLIM2 and NTN1 interact with a specific shared protein. Experimental evidence indicates that sNetrin binds exclusively to the fifth fibronectin type III repeat of this shared protein and to each immunoglobulin repeat of UNC5. Which protein is encoded by the gene corresponding to this shared entity? | Netrin receptor DCC | Medium | convergence | {"qa_id":"medium_convergence_05799","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ABLIM2 and NTN1 interact with a specific shared protein. Experimental evidence indicates that sNetrin binds exclusively to the fifth fibronectin type II... | |
medium_convergence_05801 | Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 2.21 and an adjusted p-value of 0.0027. Which cellular component is this gene located in? | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_05801","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold ... | |
medium_convergence_05802 | ATXN7 and SAP130 share multiple binding partners. One such shared partner is identified by evidence stating: 'We previously demonstrated that the SCA7 gene product, ataxin-7, is a subunit of the GCN5 histone acetyltransferase-containing coactivator complexes TFTC/STAGA.' What molecular function is enabled by this speci... | transcription coactivator activity | Medium | convergence | {"qa_id":"medium_convergence_05802","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATXN7 and SAP130 share multiple binding partners. One such shared partner is identified by evidence stating: 'We previously demonstrated that the SCA7 gene p... | |
medium_convergence_05803 | AP4E1 and AP4M1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We have shown by a combination of coimmunoprecipitation and yeast two-hybrid analysis that these four proteins (epsilon, beta4, mu4, and sigma4) are components of a novel adaptor-like heterotetr... | AP-4 complex subunit sigma-1 | Medium | convergence | {"qa_id":"medium_convergence_05803","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP4E1 and AP4M1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We have shown by a combination ... | |
medium_convergence_05804 | FANCC and FANCB each interact with more than one shared protein. Evidence concerning one shared entity reports: 'The N terminus appears to stabilize the interaction with FANCA and FANCG and is essential for the binding of the FANCC/FANCE subcomplex.' Which disease is connected to that entity through genomic alterations... | Fanconi anemia | Medium | convergence | {"qa_id":"medium_convergence_05804","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCC and FANCB each interact with more than one shared protein. Evidence concerning one shared entity reports: 'The N terminus appears to stabilize the inte... | |
medium_convergence_05805 | BIRC2 and BIRC3 both interact with a specific shared protein. Evidence regarding this protein states: 'Similarly to XIAP, in vitro binding experiments indicated that c-IAP-1 and c-IAP-2 bound specifically to the terminal effector cell death proteases, caspases-3 and -7, but not to the proximal protease caspase-8, caspa... | ovarian cancer | Medium | convergence | {"qa_id":"medium_convergence_05805","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and BIRC3 both interact with a specific shared protein. Evidence regarding this protein states: 'Similarly to XIAP, in vitro binding experiments indica... | |
medium_convergence_05806 | Both Human alphaherpesvirus 1 and Hepacivirus C are known to downregulate a specific host gene. In a study using a monocytic leukemia cell line (GSE114966), this gene exhibited a log2 fold change of -1.187 and an adjusted p-value of 0.00324. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05806","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Hepacivirus C are known to downregulate a specific host gene. In a study using a monocytic leukemia cell line (GSE114966), ... | |
medium_convergence_05807 | Both the androgen receptor (AR) and valosin-containing protein (VCP) interact with a common partner protein. Evidence indicates that this partner directly interacts with the AR protein to increase its stability, thereby enhancing its transcriptional activity. Which protein is encoded by the gene corresponding to this p... | Thioredoxin domain-containing protein 5 | Medium | convergence | {"qa_id":"medium_convergence_05807","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the androgen receptor (AR) and valosin-containing protein (VCP) interact with a common partner protein. Evidence indicates that this partner directly in... | |
medium_convergence_05809 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicates that for one such shared target, the log2 fold change is -1.374 and the adjusted p-value is 3.819e-05. Which disease ... | infectious mononucleosis | Medium | convergence | {"qa_id":"medium_convergence_05809","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific gene. Experimental data from a m... | |
medium_convergence_05810 | Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of -1.092 and an adjusted p-value of 0.006557. Which protein is encoded by this gene? | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 | Medium | convergence | {"qa_id":"medium_convergence_05810","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold c... | |
medium_convergence_05811 | UBLCP1 and PSMB8 both interact with a shared protein. Evidence indicates that this shared protein binds to proteasome subunit Rpn1 and dephosphorylates the proteasome. Which protein is encoded by this shared entity? | 26S proteasome non-ATPase regulatory subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_05811","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBLCP1 and PSMB8 both interact with a shared protein. Evidence indicates that this shared protein binds to proteasome subunit Rpn1 and dephosphorylates the p... | |
medium_convergence_05812 | CREBBP and AR both interact with a shared protein. Evidence regarding one such shared protein states: 'Using mass spectrometry to identify nuclear and cytoplasmic CBP-interacting proteins that regulate compartmentalized CBP E4 activity, we identified deleted in breast cancer 1 (a stoichiometric CBP-interacting protein)... | Wallerian degeneration | Medium | convergence | {"qa_id":"medium_convergence_05812","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and AR both interact with a shared protein. Evidence regarding one such shared protein states: 'Using mass spectrometry to identify nuclear and cytopl... | |
medium_convergence_05814 | CREBBP and BCL9L each interact with more than one shared protein. Evidence concerning one shared entity reports that transfected and endogenous human Pygopus2 and CBP proteins co-immunoprecipitate in HEK-293 cells and both proteins co-localize in SW480 colorectal cancer cells. Which molecular function is connected to t... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05814","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and BCL9L each interact with more than one shared protein. Evidence concerning one shared entity reports that transfected and endogenous human Pygopus... | |
medium_convergence_05815 | DCUN1D3 and CUL1 each interact with more than one shared protein. Evidence concerning one shared entity reports that it contains an F-box domain and is associated with the proteins Skp1, Roc-1, and Cullin-1, suggesting that it is a component of a SCF ubiquitination complex. Which protein is encoded by that entity? | F-box only protein 31 | Medium | convergence | {"qa_id":"medium_convergence_05815","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCUN1D3 and CUL1 each interact with more than one shared protein. Evidence concerning one shared entity reports that it contains an F-box domain and is assoc... | |
medium_convergence_05817 | CHEK2 and PPP2R1A each interact with more than one shared gene product. Evidence concerning one shared entity states: 'To identify new regulators of this kinase, we performed a yeast two-hybrid screen and found that Chk2 associated with the B' regulatory subunit of protein phosphatase PP2A.' Which protein is connected ... | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Medium | convergence | {"qa_id":"medium_convergence_05817","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and PPP2R1A each interact with more than one shared gene product. Evidence concerning one shared entity states: 'To identify new regulators of this kin... | |
medium_convergence_05818 | CHD3 and TOPBP1 both interact with a shared protein. Experimental evidence using nuclear co-immunoprecipitation indicates that this shared protein interacts with ATR, Claspin, and Chk1 (as part of the MutSalpha complex interactions) and with Claspin (as part of the MutLalpha complex interactions). Which protein is enco... | DNA mismatch repair protein Msh6 | Medium | convergence | {"qa_id":"medium_convergence_05818","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and TOPBP1 both interact with a shared protein. Experimental evidence using nuclear co-immunoprecipitation indicates that this shared protein interacts ... | |
medium_convergence_05819 | Both Human mastadenovirus C and Enterovirus A are associated with the upregulation of a specific gene. In a study of lung fibroblast cell lines (GSE120891), this gene exhibited a log2 fold change of approximately 2.415 and an adjusted p-value of 0.04502. Which protein is encoded by this gene? | Zinc finger protein 40 | Medium | convergence | {"qa_id":"medium_convergence_05819","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Enterovirus A are associated with the upregulation of a specific gene. In a study of lung fibroblast cell lines (GSE120891), ... | |
medium_convergence_05820 | RARA and NCOA1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In electrophoretic mobility shift assays, wild-type [Thyroid hormone receptor beta] interacted with N-CoR in the absence of ligand, whereas T3 caused dissociation of the [Thyroid hormone receptor... | Thyroid hormone receptor beta | Medium | convergence | {"qa_id":"medium_convergence_05820","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RARA and NCOA1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In electrophoretic mobility shif... | |
medium_convergence_05821 | HDAC1 and APC both interact with a shared protein. Evidence indicates that plakoglobin also associates with this shared protein. Which protein is encoded by the gene corresponding to this shared entity? | Junction plakoglobin | Medium | convergence | {"qa_id":"medium_convergence_05821","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and APC both interact with a shared protein. Evidence indicates that plakoglobin also associates with this shared protein. Which protein is encoded by ... | |
medium_convergence_05822 | EXOC8 and EXOC2 both interact with a specific protein. Evidence regarding this interaction states: 'The Sec5 subunit of the mammalian sec6/8 complex binds a small GTPase in a GTP-dependent manner.' Which protein is encoded by the gene corresponding to this interacting partner? | Ras-related protein Ral-A | Medium | convergence | {"qa_id":"medium_convergence_05822","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EXOC8 and EXOC2 both interact with a specific protein. Evidence regarding this interaction states: 'The Sec5 subunit of the mammalian sec6/8 complex binds a ... | |
medium_convergence_05823 | FGF1 and FGF16 both interact with a specific receptor protein. Evidence regarding this receptor states: 'We have crystallized a complex between human FGF1 and a two-domain extracellular fragment of human [receptor].' Which protein is encoded by the gene corresponding to this receptor? | Fibroblast growth factor receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_05823","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF1 and FGF16 both interact with a specific receptor protein. Evidence regarding this receptor states: 'We have crystallized a complex between human FGF1 an... | |
medium_convergence_05824 | NIPBL and STRA6 are both associated with multiple shared biological processes. A specific study reports: 'We identified mutations in one gene in this region, which we named NIPBL, in four sporadic and two familial cases of CdLS.' Based on this evidence, which shared biological process is connected to NIPBL through an '... | growth | Medium | convergence | {"qa_id":"medium_convergence_05824","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NIPBL and STRA6 are both associated with multiple shared biological processes. A specific study reports: 'We identified mutations in one gene in this region,... | |
medium_convergence_05825 | CREBBP and ARNT each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We have previously shown that the C-terminal PAS domains of an HIF-alpha isoform (HIF-2alpha) and ARNT interact in vitro, and that mutations in the solvent-exposed beta-sheet surface of the HIF-... | Endothelial PAS domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05825","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and ARNT each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We have previously shown that t... | |
medium_convergence_05826 | MEF2A and MEF2C each interact with more than one shared gene product. Evidence concerning one of these shared entities states: 'The myogenic bHLH proteins cooperatively activate transcription and myogenesis through protein-protein interactions with members of the myocyte enhancer factor 2 (MEF2) family of MADS domain t... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_05826","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MEF2A and MEF2C each interact with more than one shared gene product. Evidence concerning one of these shared entities states: 'The myogenic bHLH proteins co... | |
medium_convergence_05827 | Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a log2 fold change of approximately 1.155 and an adjusted p-value of 0.01493. Which disease is associated with this gene as a biomarker? | multiple sclerosis | Medium | convergence | {"qa_id":"medium_convergence_05827","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a ... | |
medium_convergence_05830 | SMOC2 and VEGFA are both associated with multiple shared biological processes. One specific shared process is supported by evidence that SMOC-2 adenovirus induced a 3-fold increase in the number of cells invading Matrigel plugs compared to a control. Which biological process is positively regulated by this shared entit... | endothelial cell chemotaxis | Medium | convergence | {"qa_id":"medium_convergence_05830","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMOC2 and VEGFA are both associated with multiple shared biological processes. One specific shared process is supported by evidence that SMOC-2 adenovirus in... | |
medium_convergence_05831 | LAMTOR1 and ATG101 both interact with a specific protein complex component. Evidence indicates that a complex termed Ragulator, encoded by the MAPKSP1, ROBLD3, and c11orf59 genes, interacts with Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation. Which protein, among those shared by LAMTOR1... | Ras-related GTP-binding protein C | Medium | convergence | {"qa_id":"medium_convergence_05831","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR1 and ATG101 both interact with a specific protein complex component. Evidence indicates that a complex termed Ragulator, encoded by the MAPKSP1, ROBLD... | |
medium_convergence_05833 | ACTN4 and CAV1 both interact with a specific protein. Evidence states: 'Here, we report that actinin-4, an actin-bundling protein, is a potential binding partner for the protein encoded by COL17A1.' Which protein is encoded by the gene corresponding to this shared interaction partner? | Collagen alpha-1(XVII) chain | Medium | convergence | {"qa_id":"medium_convergence_05833","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTN4 and CAV1 both interact with a specific protein. Evidence states: 'Here, we report that actinin-4, an actin-bundling protein, is a potential binding par... | |
medium_convergence_05834 | Human betaherpesvirus 5 and Human respirovirus 3 both upregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of 3.582 and an adjusted p-value of 0.0004512. Which protein is encoded by this gene? | Stanniocalcin-1 | Medium | convergence | {"qa_id":"medium_convergence_05834","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human respirovirus 3 both upregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of 3.582 and a... | |
medium_convergence_05835 | POLA1 and POLD4 both interact with a shared protein partner. Evidence regarding this partner states: 'Conversely, a pol1 peptide spanning the last 16 residues binds primase with high affinity, and the equivalent peptide from human Pol α binds primase in an analogous fashion.' Which protein is encoded by the gene corres... | DNA primase large subunit | Medium | convergence | {"qa_id":"medium_convergence_05835","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLA1 and POLD4 both interact with a shared protein partner. Evidence regarding this partner states: 'Conversely, a pol1 peptide spanning the last 16 residue... | |
medium_convergence_05836 | RHOB and PPP1CC both interact with a common protein partner. Experimental evidence indicates that this partner is selectively targeted by PP1gamma1 in brain and muscle extracts, distinguishing it from partners of PP1beta. Which protein is encoded by this shared interaction partner? | Neurabin-1 | Medium | convergence | {"qa_id":"medium_convergence_05836","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOB and PPP1CC both interact with a common protein partner. Experimental evidence indicates that this partner is selectively targeted by PP1gamma1 in brain ... | |
medium_convergence_05837 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific gene. In a study of lung fibroblast cell lines (GSE120891), one such shared target exhibited a log2 fold change of approximately 2.95 and an adjusted p-value of 0.038. Which protein is encoded by thi... | Intercellular adhesion molecule 1 | Medium | convergence | {"qa_id":"medium_convergence_05837","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific gene. In a study of lung fibroblast ... | |
medium_convergence_05839 | CHUK and TBK1 share common interaction partners. One such shared partner is implicated in a mechanism where TXLNA impairs its binding to TBK1, thereby inhibiting the dephosphorylation of TBK1 and contributing to the abnormal enhancement of TBK1 activity in cancer cells. Which protein is encoded by this shared partner? | Protein phosphatase 1B | Medium | convergence | {"qa_id":"medium_convergence_05839","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and TBK1 share common interaction partners. One such shared partner is implicated in a mechanism where TXLNA impairs its binding to TBK1, thereby inhibi... | |
medium_convergence_05840 | HRAS and NRAS both interact with a specific guanine nucleotide dissociation stimulator (GDS) that regulates guanine nucleotide exchange on Ral. Which cell type is this GDS enriched in? | gamma-delta T cell | Medium | convergence | {"qa_id":"medium_convergence_05840","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HRAS and NRAS both interact with a specific guanine nucleotide dissociation stimulator (GDS) that regulates guanine nucleotide exchange on Ral. Which cell ty... | |
medium_convergence_05841 | FANCC and FANCF each interact with more than one shared gene product. Evidence concerning one shared entity reports that the protein is a component of a nuclear protein complex containing FANCA and FANCC. Which cell type is connected to that entity through the 'enriched in' relationship? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05841","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCC and FANCF each interact with more than one shared gene product. Evidence concerning one shared entity reports that the protein is a component of a nucl... | |
medium_convergence_05842 | Both aorta smooth muscle tissue and arteriole smooth muscle are types of a specific shared anatomical entity. Evidence regarding this entity states: 'The nonstriated, involuntary muscle tissue located in the wall of the aorta.' Which anatomical structure is this shared entity a part of? | arterial system | Medium | convergence | {"qa_id":"medium_convergence_05842","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both aorta smooth muscle tissue and arteriole smooth muscle are types of a specific shared anatomical entity. Evidence regarding this entity states: 'The non... | |
medium_convergence_05843 | DAB1 and EGFR both interact with a shared protein entity. Evidence regarding this entity states: 'Using yeast 2-hybrid and protein coprecipitation approaches in vitro, we show that the neuronal adaptor proteins FE65 and mammalian Disabled bind to the cytoplasmic tails of a low-density lipoprotein receptor-related prote... | Alzheimer disease | Medium | convergence | {"qa_id":"medium_convergence_05843","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAB1 and EGFR both interact with a shared protein entity. Evidence regarding this entity states: 'Using yeast 2-hybrid and protein coprecipitation approaches... | |
medium_convergence_05844 | MAP3K11 and ARHGEF2 both interact with a common protein scaffold. Experimental evidence indicates that TRAF6-mediated ubiquitination is required for the dissociation of inactive monomeric MLK3 from this scaffold, identified as a JNK-interacting protein, thereby facilitating the subsequent dimerization, autophosphorylat... | C-Jun-amino-terminal kinase-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05844","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP3K11 and ARHGEF2 both interact with a common protein scaffold. Experimental evidence indicates that TRAF6-mediated ubiquitination is required for the diss... | |
medium_convergence_05845 | H2AX and SMARCC1 share multiple interacting partners. One such shared partner is the subject of a study reporting: 'In this study we solve the crystal structures of the natural variant (A761) C-terminal tandem BRCT domains alone as well as in complex with γH2AX tail.' Which protein is encoded by this shared partner? | Microcephalin | Medium | convergence | {"qa_id":"medium_convergence_05845","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and SMARCC1 share multiple interacting partners. One such shared partner is the subject of a study reporting: 'In this study we solve the crystal struct... | |
medium_convergence_05846 | PRKDC and YWHAZ share common interaction partners. One such shared partner is associated with a histone acetyltransferase, which has been found to interact with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a key component of nonhomologous end-joining (NHEJ) repair. Which protein is encoded by this sha... | Histone acetyltransferase KAT8 | Medium | convergence | {"qa_id":"medium_convergence_05846","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKDC and YWHAZ share common interaction partners. One such shared partner is associated with a histone acetyltransferase, which has been found to interact w... | |
medium_convergence_05847 | Human betaherpesvirus 5 and Pegivirus C both upregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of approximately 1.299 and an adjusted p-value of 0.001977. Which protein is encoded by this gene? | Serine/threonine-protein kinase pim-3 | Medium | convergence | {"qa_id":"medium_convergence_05847","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Pegivirus C both upregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of approximately 1.299 ... | |
medium_convergence_05848 | EGFR and KRAS share a common interacting partner. Evidence indicates that a specific calcium-binding protein associates directly with the kinase domain of this shared partner in a ligand-dependent manner. Which protein is encoded by this shared interacting partner? | Guided entry of tail-anchored proteins factor CAMLG | Medium | convergence | {"qa_id":"medium_convergence_05848","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and KRAS share a common interacting partner. Evidence indicates that a specific calcium-binding protein associates directly with the kinase domain of th... | |
medium_convergence_05849 | CLNS1A and COPRS each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We have recently described a large (20 S) protein arginine methyltransferase complex, termed the methylosome, that contains the methyltransferase JBP1 and the pICln protein.' Which protein is encoded by tha... | Protein arginine N-methyltransferase 5 | Medium | convergence | {"qa_id":"medium_convergence_05849","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLNS1A and COPRS each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We have recently described a large (20 S) p... | |
medium_convergence_05850 | Both XRCC6 and PRKDC interact with a specific shared protein. Evidence indicates that for this shared protein, the Ku70 subunit specifically interacts with its N-terminus (amino acids 1-368), while the Ku80 subunit interacts with its C-terminus (amino acids 940-1432). Which protein is this shared entity? | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_05850","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both XRCC6 and PRKDC interact with a specific shared protein. Evidence indicates that for this shared protein, the Ku70 subunit specifically interacts with i... | |
medium_convergence_05851 | EGF and PDGFB are both involved in more than one shared biological process. Evidence indicates that human dermal fibroblasts exhibited the highest hyaluronan-synthesizing activity in response to PDGF-BB. Which biological process, connected to the entity implicated by this evidence, is the target of the 'positively regu... | hyaluronan biosynthetic process | Medium | convergence | {"qa_id":"medium_convergence_05851","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGF and PDGFB are both involved in more than one shared biological process. Evidence indicates that human dermal fibroblasts exhibited the highest hyaluronan... | |
medium_convergence_05852 | The angular vein and the palpebral vein share a common anatomical classification. Evidence regarding one such shared entity states: 'The angular vein, formed by the junction of the frontal vein and supraorbital vein, runs obliquely downward, on the side of the root of the nose, to the level of the lower margin of the o... | cranial blood vasculature | Medium | convergence | {"qa_id":"medium_convergence_05852","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The angular vein and the palpebral vein share a common anatomical classification. Evidence regarding one such shared entity states: 'The angular vein, formed... | |
medium_convergence_05853 | KMT2C and MED20 both interact with a shared protein. Evidence indicates that this shared entity is Activating signal cointegrator-2 (ASC-2), a coactivator of transcription factors such as the retinoic acid receptor (RAR), which associates with histone H3-K4 methyltransferases MLL3 and MLL4 in mixed-lineage leukemia. Wh... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_05853","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KMT2C and MED20 both interact with a shared protein. Evidence indicates that this shared entity is Activating signal cointegrator-2 (ASC-2), a coactivator of... | |
medium_convergence_05854 | Human betaherpesvirus 5 and Dengue virus both upregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE120891) reports a log2 fold change of approximately 2.57 and an adjusted p-value of 0.0032. Which protein is encoded by this gene? | Krueppel-like factor 4 | Medium | convergence | {"qa_id":"medium_convergence_05854","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Dengue virus both upregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GS... | |
medium_convergence_05855 | ANAPC7 and AURKA share common binding partners. One such shared partner is identified as a gene encoding a protein that binds APC16 and APC7 and contains a >200-residue loop that is heavily phosphorylated during mitosis. Which gene interacts with this specific shared partner? | CDH1 | Medium | convergence | {"qa_id":"medium_convergence_05855","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC7 and AURKA share common binding partners. One such shared partner is identified as a gene encoding a protein that binds APC16 and APC7 and contains a >... | |
medium_convergence_05856 | HUWE1 and CDKN2A share multiple interacting partners. One such shared partner is described as a component of the 19 S regulatory subunit of the 26 S proteasome, which is involved in transcriptional regulation and cell proliferation control, and specifically interacts with ARF in both yeast and mammalian cells. Which di... | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_05856","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and CDKN2A share multiple interacting partners. One such shared partner is described as a component of the 19 S regulatory subunit of the 26 S proteaso... | |
medium_convergence_05857 | RANBP9 and ARMC8 both interact with a shared gene product. Experimental evidence indicates that RanBPM (encoded by RANBP9) was identified as a binding partner for this shared entity using the yeast two-hybrid method. Which cellular component is this shared entity located in? | ubiquitin ligase complex | Medium | convergence | {"qa_id":"medium_convergence_05857","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RANBP9 and ARMC8 both interact with a shared gene product. Experimental evidence indicates that RanBPM (encoded by RANBP9) was identified as a binding partne... | |
medium_convergence_05858 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that this gene exhibits a log2 fold change of approximately 1.738 and an adjusted p-value of 0.03048. Which cel... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_05858","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from ... | |
medium_convergence_05859 | Vaccinia virus and Dengue virus both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 4.205 and an adjusted p-value of 1.284e-09. Which biological process is this gene involved in? | chromosome segregation | Medium | convergence | {"qa_id":"medium_convergence_05859","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Dengue virus both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log... | |
medium_convergence_05860 | THRA and VDR share multiple interacting partners. One such shared partner is characterized by evidence stating that 'This protein interacts with TR only in the absence of hormone.' Which protein product is encoded by this specific shared partner? | COP9 signalosome complex subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_05860","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"THRA and VDR share multiple interacting partners. One such shared partner is characterized by evidence stating that 'This protein interacts with TR only in t... | |
medium_convergence_05861 | SMG1 and ATR share common interaction partners. One such shared partner is reported to interact with and stabilize all six members of the PIKK family of proteins (mTOR, ATM, the partner itself, DNA-PKcs, SMG-1, and TRRAP). Which protein is encoded by the gene corresponding to this shared partner? | TELO2-interacting protein 1 homolog | Medium | convergence | {"qa_id":"medium_convergence_05861","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMG1 and ATR share common interaction partners. One such shared partner is reported to interact with and stabilize all six members of the PIKK family of prot... | |
medium_convergence_05862 | Both Human alphaherpesvirus 3 and Zaire ebolavirus are reported to downregulate a specific host gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.28 and an adjusted p-value of approximately 6.02e-07. Which protein is encoded by t... | Ubiquitin-associated and SH3 domain-containing protein B | Medium | convergence | {"qa_id":"medium_convergence_05862","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zaire ebolavirus are reported to downregulate a specific host gene. Experimental data from a melanoma cell line (study GSE1... | |
medium_convergence_05864 | Human betaherpesvirus 5 and Human respirovirus 3 both upregulate a specific gene. Experimental data for this gene shows a log2 fold change of 7.739 and an adjusted p-value of 0.008893. Which protein is encoded by this gene? | Cholesterol 25-hydroxylase | Medium | convergence | {"qa_id":"medium_convergence_05864","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human respirovirus 3 both upregulate a specific gene. Experimental data for this gene shows a log2 fold change of 7.739 and an ad... | |
medium_convergence_05866 | Doxylamine and Cyproheptadine both interact with a specific shared drug. Evidence indicates that while p-Chlorophenylalanine and methergoline had no effect, this shared drug enhanced the anticonvulsive action of most benzodiazepines tested. Which disease is this shared drug indicated for? | anxiety | Medium | convergence | {"qa_id":"medium_convergence_05866","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Doxylamine and Cyproheptadine both interact with a specific shared drug. Evidence indicates that while p-Chlorophenylalanine and methergoline had no effect, ... | |
medium_convergence_05867 | CSNK2A1 and EGFR share multiple interacting partners. One such partner is implicated in evidence stating that Casein kinase II (CKII) is the major kinase mediating arrestin-3 phosphorylation, supported by the presence of Thr-382 within a canonical CKII consensus sequence and the observation that wild-type arrestin-3, b... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_05867","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and EGFR share multiple interacting partners. One such partner is implicated in evidence stating that Casein kinase II (CKII) is the major kinase med... |
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