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medium_convergence_05868 | KHDRBS1 and FGFR1 share multiple interacting partners. One such partner is supported by evidence stating: 'Co-immunoprecipitation studies revealed that the YES1 gene product directly associated with FGFR-1beta.' Which disease is linked to this specific interacting partner via a biomarker relationship? | malignant colon neoplasm | Medium | convergence | {"qa_id":"medium_convergence_05868","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KHDRBS1 and FGFR1 share multiple interacting partners. One such partner is supported by evidence stating: 'Co-immunoprecipitation studies revealed that the Y... | |
medium_convergence_05870 | TRIM28 and CHEK1 both interact with a specific shared protein. Evidence regarding this shared protein states: 'We identified a novel interaction between this protein and checkpoint kinase CHK1 and showed that the defective damage response in cells deficient for this protein is at least in part due to altered CHK1 subce... | DNA (cytosine-5)-methyltransferase 1 | Medium | convergence | {"qa_id":"medium_convergence_05870","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CHEK1 both interact with a specific shared protein. Evidence regarding this shared protein states: 'We identified a novel interaction between this... | |
medium_convergence_05871 | Both YWHAE and YWHAH interact with multiple shared genes. One of these shared partners is described in evidence stating: 'We now report that the adaptor proteins 14-3-3 bind to hMex-3B but not to the three other hMex-3 family members.' Identify the gene corresponding to this entity, and then determine which gene it int... | CFLAR | Medium | convergence | {"qa_id":"medium_convergence_05871","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both YWHAE and YWHAH interact with multiple shared genes. One of these shared partners is described in evidence stating: 'We now report that the adaptor prot... | |
medium_convergence_05872 | Both ACTN4 and ACTN1 share a binding partner. A study reports that actinin-4 (encoded by ACTN4) is a potential binding partner for a specific protein. Which protein is encoded by the gene corresponding to this specific protein? | Collagen alpha-1(XVII) chain | Medium | convergence | {"qa_id":"medium_convergence_05872","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ACTN4 and ACTN1 share a binding partner. A study reports that actinin-4 (encoded by ACTN4) is a potential binding partner for a specific protein. Which ... | |
medium_convergence_05873 | TSG101 and CHMP6 both physically interact with a specific shared protein. Evidence indicates that this shared protein is a component of a complex containing a fraction of total cellular TSG101 and VPS37A, but explicitly excluding VPS37C. Which gene interacts with this shared protein? | ZFYVE16 | Medium | convergence | {"qa_id":"medium_convergence_05873","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TSG101 and CHMP6 both physically interact with a specific shared protein. Evidence indicates that this shared protein is a component of a complex containing ... | |
medium_convergence_05874 | EGFR and PTPN11 share a common interacting partner. Evidence indicates that this partner is recruited to EGFRvIII and inhibits the transformation of NIH 3T3 cells by EGFRvIII. Which cell type is enriched for this shared interacting partner? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_05874","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and PTPN11 share a common interacting partner. Evidence indicates that this partner is recruited to EGFRvIII and inhibits the transformation of NIH 3T3 ... | |
medium_convergence_05875 | RAD51 and BLM both interact with a shared protein partner. Experimental evidence indicates that phosphorylation of this shared partner by c-Abl enhances its complex formation with RAD51, a process that cooperates with RAD51 in recombination and repair. Which protein is encoded by the gene corresponding to this shared p... | DNA repair protein RAD52 homolog | Medium | convergence | {"qa_id":"medium_convergence_05875","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51 and BLM both interact with a shared protein partner. Experimental evidence indicates that phosphorylation of this shared partner by c-Abl enhances its ... | |
medium_convergence_05876 | Both Vaccinia virus and Enterovirus A are associated with the downregulation of a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of approximately -1.45 and an adjusted p-value of 0.00725. Which protein is encoded by this gene? | Reversion-inducing cysteine-rich protein with Kazal motifs | Medium | convergence | {"qa_id":"medium_convergence_05876","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Enterovirus A are associated with the downregulation of a specific gene. In a study using a cervical adenocarcinoma cell line (GSE112... | |
medium_convergence_05877 | KHDRBS1 and FGFR1 share multiple interacting partners. One such partner is supported by evidence stating: 'Co-immunoprecipitation studies revealed that the kinase encoded by YES1 directly associated with FGFR-1beta.' Which cell type is this specific partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05877","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KHDRBS1 and FGFR1 share multiple interacting partners. One such partner is supported by evidence stating: 'Co-immunoprecipitation studies revealed that the k... | |
medium_convergence_05879 | ERCC4 and ERCC6 each share a binding partner with another gene. Evidence concerning one such shared partner indicates that a protein encoded by that partner gene interacts with the CSB protein and with the p44 protein, a subunit of the human RNA polymerase II transcription factor IIH. Which protein is encoded by that s... | DNA excision repair protein ERCC-8 | Medium | convergence | {"qa_id":"medium_convergence_05879","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC4 and ERCC6 each share a binding partner with another gene. Evidence concerning one such shared partner indicates that a protein encoded by that partner ... | |
medium_convergence_05880 | Both MEN1 and ATM interact with a shared protein. Evidence indicates that this shared protein associates with a zinc finger protein in an HDACi-dependent manner, as revealed by co-immunoprecipitation. Which protein is encoded by this shared entity? | Zinc finger protein 148 | Medium | convergence | {"qa_id":"medium_convergence_05880","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both MEN1 and ATM interact with a shared protein. Evidence indicates that this shared protein associates with a zinc finger protein in an HDACi-dependent man... | |
medium_convergence_05881 | CHUK and AKT1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Fourth, PKC theta co-immunoprecipitated with Akt1; however, neither Akt1 nor PKC theta served as a prominent substrate for each other in vitro as well as in intact T cells.' Which protein is encoded by the gene co... | Protein kinase C theta type | Medium | convergence | {"qa_id":"medium_convergence_05881","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and AKT1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Fourth, PKC theta co-immunoprecipitated with Akt1;... | |
medium_convergence_05882 | PRKAA1 and PRKAA2 both interact with a specific regulatory subunit of the AMP-activated protein kinase (AMPK) complex. Evidence indicates that AMPKbeta and AMPKgamma subunits associate with AMPKalpha, but not with AMPK-related kinases, which explains why AMP does not influence the activity of those related kinases. Bas... | 5'-AMP-activated protein kinase subunit beta-1 | Medium | convergence | {"qa_id":"medium_convergence_05882","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKAA1 and PRKAA2 both interact with a specific regulatory subunit of the AMP-activated protein kinase (AMPK) complex. Evidence indicates that AMPKbeta and A... | |
medium_convergence_05883 | CHD4 and DPF3 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In the ovary, this protein interacted with NuRD proteins CHD4 and HDAC1 and the core cohesin complex protein RAD21.' Which protein is encoded by this gene? | Metastasis-associated protein MTA3 | Medium | convergence | {"qa_id":"medium_convergence_05883","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and DPF3 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In the ovary, this protein intera... | |
medium_convergence_05884 | Both RIGI and HTT share interaction partners. One such shared partner is identified in evidence stating: 'Using the yeast two-hybrid system, we have identified a human ubiquitin-conjugating enzyme (hE2-25K) as a protein that interacts with the gene product for Huntington disease (HD) (Huntingtin).' Which protein is enc... | Ubiquitin-conjugating enzyme E2 K | Medium | convergence | {"qa_id":"medium_convergence_05884","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both RIGI and HTT share interaction partners. One such shared partner is identified in evidence stating: 'Using the yeast two-hybrid system, we have identifi... | |
medium_convergence_05885 | Fluconazole and Quinine both interact with a specific drug. Evidence regarding this drug states: 'We used chemical genetics to elucidate the mode of action of the antimycobacterial drug, a compound with unreported antifungal activity that synergized with several antifungals.' Which disease is this drug indicated for? | lepromatous leprosy | Medium | convergence | {"qa_id":"medium_convergence_05885","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Fluconazole and Quinine both interact with a specific drug. Evidence regarding this drug states: 'We used chemical genetics to elucidate the mode of action o... | |
medium_convergence_05886 | CFTR and COPS5 share common interacting partners. One such shared partner is described by evidence stating: 'We have found that psoriasin physically interacts with Jab1 (c-jun activation-domain binding protein 1) in the yeast two-hybrid assay and confirmed this by coimmunoprecipitation assay in breast cancer cells.' Wh... | fibroma | Medium | convergence | {"qa_id":"medium_convergence_05886","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFTR and COPS5 share common interacting partners. One such shared partner is described by evidence stating: 'We have found that psoriasin physically interact... | |
medium_convergence_05887 | Both IKBKB and BCL10 interact with a common protein partner. Evidence regarding this shared partner states: 'The human paracaspase prodomain binds Bcl10, a protein involved in the t(1;14)(p22;q32) translocation of mucosa-associated lymphoid tissue (MALT) lymphoma.' Which protein is encoded by the gene corresponding to ... | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05887","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKB and BCL10 interact with a common protein partner. Evidence regarding this shared partner states: 'The human paracaspase prodomain binds Bcl10, a p... | |
medium_convergence_05888 | NEDD4L and NEDD4 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We show that this protein binds the ubiquitin-ligase Nedd4 and GGA3 to promote its sorting from the Golgi to the lysosome, an event that is independent of its ubiquitination.' Which protein is connecte... | Lysosomal-associated transmembrane protein 5 | Medium | convergence | {"qa_id":"medium_convergence_05888","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and NEDD4 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We show that this protein binds the ub... | |
medium_convergence_05889 | The biological processes 'regulation of branching involved in lung morphogenesis' and 'regulation of branching involved in ureteric bud morphogenesis' share a common parent process. Evidence for this shared entity describes it as: 'Any process that modulates the rate, frequency, or extent of the process in which a high... | morphogenesis of a branching structure | Medium | convergence | {"qa_id":"medium_convergence_05889","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of branching involved in lung morphogenesis' and 'regulation of branching involved in ureteric bud morphogenesis' share ... | |
medium_convergence_05891 | YWHAQ and CCNY both interact with a specific protein. Evidence regarding this protein states: 'Using the yeast two-hybrid system we screened a mouse brain cDNA library with a specific kinase as bait, and isolated several clones coding for the mouse homologs of the following proteins: p11 (also known as calpactin I ligh... | Cyclin-dependent kinase 16 | Medium | convergence | {"qa_id":"medium_convergence_05891","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and CCNY both interact with a specific protein. Evidence regarding this protein states: 'Using the yeast two-hybrid system we screened a mouse brain cD... | |
medium_convergence_05892 | WWP1 and EPS15 both interact with a shared protein. Mass spectrometry evidence confirms that this shared protein interacts with ubiquitin and the E3 ubiquitin-protein ligases AIP4 (Itch) and AIP5 (WWP1). Which gene encodes this shared protein? | Spartin | Medium | convergence | {"qa_id":"medium_convergence_05892","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WWP1 and EPS15 both interact with a shared protein. Mass spectrometry evidence confirms that this shared protein interacts with ubiquitin and the E3 ubiquiti... | |
medium_convergence_05894 | CSNK2B and AKT1 both interact with a shared protein. Evidence indicates that the regulatory beta-subunit of protein kinase CK2 interacts with this shared protein in high molecular mass complexes, in addition to CK2's ability to phosphorylate it. Which protein is encoded by this shared entity? | Wee1-like protein kinase | Medium | convergence | {"qa_id":"medium_convergence_05894","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and AKT1 both interact with a shared protein. Evidence indicates that the regulatory beta-subunit of protein kinase CK2 interacts with this shared pro... | |
medium_convergence_05895 | Both Human betaherpesvirus 5 and Human orthopneumovirus are associated with the upregulation of a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of approximately 1.274 and an adjusted p-value of 0.01232. Which protein is encoded by this gene... | Nuclear factor interleukin-3-regulated protein | Medium | convergence | {"qa_id":"medium_convergence_05895","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Human orthopneumovirus are associated with the upregulation of a specific gene. Experimental data for this gene in foreskin ... | |
medium_convergence_05896 | CRY1 and FBXW11 both interact with a specific circadian protein. Evidence indicates that this protein, along with CRY1 and CRY2, engages in light-independent interactions with CLOCK, BMAL1, and TIM. Which protein is encoded by the gene corresponding to this interacting partner? | Period circadian protein homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_05896","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRY1 and FBXW11 both interact with a specific circadian protein. Evidence indicates that this protein, along with CRY1 and CRY2, engages in light-independent... | |
medium_convergence_05897 | STK4 and TMPO share a common interacting partner. Evidence for one such partner states: 'Here I identified a LAP2 interacting protein, termed L2BP1 (LAP2 binding protein 1).' Which disease is associated with this specific shared partner via a biomarker relationship? | nervous system disorder | Medium | convergence | {"qa_id":"medium_convergence_05897","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STK4 and TMPO share a common interacting partner. Evidence for one such partner states: 'Here I identified a LAP2 interacting protein, termed L2BP1 (LAP2 bin... | |
medium_convergence_05898 | CEBPA and EP300 both interact with a shared protein. Evidence regarding this shared entity states: 'We demonstrate that the ets DNA-binding subunit of GABP, physically interacts with p300 in myeloid cells.' Which protein product is encoded by this shared entity? | GA-binding protein alpha chain | Medium | convergence | {"qa_id":"medium_convergence_05898","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPA and EP300 both interact with a shared protein. Evidence regarding this shared entity states: 'We demonstrate that the ets DNA-binding subunit of GABP, ... | |
medium_convergence_05900 | ORC1 and MCM8 share common binding partners. One such shared partner is described by evidence stating: 'Further analyses indicate that this protein physically interacts with ORC1 on non-chromatin nuclear structures.' Which disease is associated with this specific shared partner? | Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome | Medium | convergence | {"qa_id":"medium_convergence_05900","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ORC1 and MCM8 share common binding partners. One such shared partner is described by evidence stating: 'Further analyses indicate that this protein physicall... | |
medium_convergence_05901 | GNB5 and GNB4 both interact with multiple shared partners. One such partner is described by evidence stating: 'In vitro translation co-precipitation analyses revealed that Gbeta4 can form stable dimers with Ggamma1, Ggamma2, Ggamma3, Ggamma4, Ggamma5, Ggamma7, Ggamma10, Ggamma11, Ggamma12, and Ggamma13, dimers which we... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | Medium | convergence | {"qa_id":"medium_convergence_05901","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNB5 and GNB4 both interact with multiple shared partners. One such partner is described by evidence stating: 'In vitro translation co-precipitation analyses... | |
medium_convergence_05902 | KMT2A and BTRC both interact with a shared protein. Evidence indicates that SUMO2 conjugation facilitates the interaction of this shared protein with β-TrCP, leading to its proteasomal degradation. Which protein is encoded by the gene corresponding to this shared entity? | Period circadian protein homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_05902","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KMT2A and BTRC both interact with a shared protein. Evidence indicates that SUMO2 conjugation facilitates the interaction of this shared protein with β-TrCP,... | |
medium_convergence_05903 | EP300 and SMAD1 share a common interaction partner. Experimental evidence indicates that a monoclonal antibody raised against the carboxyl terminus of this shared entity coimmunoprecipitates CBP/p300, supporting the model that the entity is a CBP binding protein found in a cellular protein complex. Which protein is enc... | Chromatin remodeling protein SRCAP | Medium | convergence | {"qa_id":"medium_convergence_05903","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and SMAD1 share a common interaction partner. Experimental evidence indicates that a monoclonal antibody raised against the carboxyl terminus of this s... | |
medium_convergence_05904 | HLA-A and HLA-C both interact with a specific protein complex component. Evidence indicates that the T134K variant's inefficiency in presenting intracellular antigen is linked to its failure to interact with the TAP heterodimer. Which disease is associated with this specific protein component via a biomarker relationsh... | glaucoma | Medium | convergence | {"qa_id":"medium_convergence_05904","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HLA-A and HLA-C both interact with a specific protein complex component. Evidence indicates that the T134K variant's inefficiency in presenting intracellular... | |
medium_convergence_05905 | ESR1 and JAK2 each interact with more than one shared protein. Evidence concerning one of these shared proteins indicates that it interacts with ERalpha as well as with the general transcriptional coactivators p300 and CBP (cAMP response element-binding protein-binding protein). Which protein is encoded by the gene cor... | Proline-, glutamic acid- and leucine-rich protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05905","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and JAK2 each interact with more than one shared protein. Evidence concerning one of these shared proteins indicates that it interacts with ERalpha as w... | |
medium_convergence_05906 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (study GSE100576) reports a log2 fold change of approximately 1.709 and an adjusted p-value of 0.008871. Which protein does this upregulated gene product interact wit... | IFIT3 | Medium | convergence | {"qa_id":"medium_convergence_05906","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (st... | |
medium_convergence_05908 | CBX3 and CBX8 both interact with a specific histone H3 variant gene. Evidence regarding this shared entity states: 'We find that the chromoshadow-domain interacts with histone H3 in a region located partially inside the nucleosomal barrel at the entry/exit point of the nucleosome.' Which protein is encoded by this shar... | Histone H3.1 | Medium | convergence | {"qa_id":"medium_convergence_05908","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and CBX8 both interact with a specific histone H3 variant gene. Evidence regarding this shared entity states: 'We find that the chromoshadow-domain inte... | |
medium_convergence_05909 | CBX3 and ANAPC16 both interact with a specific protein. Evidence regarding this protein indicates that automethylation of a histone methyltransferase at the ARKT motif creates a binding site for the HP1 class of proteins, and that mutation of the lysine in this motif impairs this binding. Which protein is encoded by th... | Histone-lysine N-methyltransferase EHMT2 | Medium | convergence | {"qa_id":"medium_convergence_05909","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and ANAPC16 both interact with a specific protein. Evidence regarding this protein indicates that automethylation of a histone methyltransferase at the ... | |
medium_convergence_05910 | DLG1 and GRIN2B both interact with a specific Ca(2+)/calmodulin-dependent Ras-guanine-nucleotide-releasing factor. Experimental evidence indicates that the NR2B subunit of the NMDAR, but not the NR2A or NR1 subunits, interacts with this factor in vivo and in vitro. Which disease is associated with this factor through g... | infantile spasms | Medium | convergence | {"qa_id":"medium_convergence_05910","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG1 and GRIN2B both interact with a specific Ca(2+)/calmodulin-dependent Ras-guanine-nucleotide-releasing factor. Experimental evidence indicates that the N... | |
medium_convergence_05911 | SIN3A and TRIM27 both interact with a shared protein. Evidence indicates that this shared protein directly binds to SIN3A and HDAC1 at three central regions that overlap transcriptional repression domains. Which protein is encoded by the gene corresponding to this shared entity? | Methyl-CpG-binding domain protein 4 | Medium | convergence | {"qa_id":"medium_convergence_05911","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and TRIM27 both interact with a shared protein. Evidence indicates that this shared protein directly binds to SIN3A and HDAC1 at three central regions ... | |
medium_convergence_05913 | Ketoconazole and Dasatinib both interact with a specific drug. Evidence regarding this drug indicates that a pharmacokinetic model performed well in recovering the observed effects of CYP3A4 inhibitors (specifically the drug itself and cyclosporine) and the CYP3A4 inducer rifampicin, as well as in predicting interactio... | pulmonary arterial hypertension | Medium | convergence | {"qa_id":"medium_convergence_05913","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Ketoconazole and Dasatinib both interact with a specific drug. Evidence regarding this drug indicates that a pharmacokinetic model performed well in recoveri... | |
medium_convergence_05914 | ESR1 and AR each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'The largest member of this family, Bag-1L, enhances the transactivation function of the androgen receptor.' Which protein is connected to that entity through the 'encodes' relation? | BAG family molecular chaperone regulator 1 | Medium | convergence | {"qa_id":"medium_convergence_05914","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and AR each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'The largest member of this family, Bag-1L, ... | |
medium_convergence_05915 | BRCA2 and FAAP24 both interact with a specific shared protein. Experimental evidence for this shared protein states: 'We found that the protein was capable of binding to two separate sites in the BRCA2 protein, located either side of the BRC repeats.' Which protein is encoded by the gene corresponding to this shared en... | Fanconi anemia group G protein | Medium | convergence | {"qa_id":"medium_convergence_05915","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCA2 and FAAP24 both interact with a specific shared protein. Experimental evidence for this shared protein states: 'We found that the protein was capable o... | |
medium_convergence_05916 | TNIP1 and SEPT9 share a common interacting partner. Evidence indicates that cyclin-dependent kinase 1 (Cdk1) phosphorylates SEPT9 upon mitotic entry, a modification that controls its association with a specific proline isomerase. Which protein is encoded by this shared interacting partner? | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Medium | convergence | {"qa_id":"medium_convergence_05916","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNIP1 and SEPT9 share a common interacting partner. Evidence indicates that cyclin-dependent kinase 1 (Cdk1) phosphorylates SEPT9 upon mitotic entry, a modif... | |
medium_convergence_05917 | CYLD and TBK1 share a common interaction partner. Evidence indicates that this shared partner interacts with CYLD to promote APC/C-mediated E3 ligase activity, leading to the ubiquitination and subsequent 26S proteasomal degradation of PFKFB3. Which cellular component is this shared partner located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_05917","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CYLD and TBK1 share a common interaction partner. Evidence indicates that this shared partner interacts with CYLD to promote APC/C-mediated E3 ligase activit... | |
medium_convergence_05918 | Cyclosporine and Sorafenib share a common drug interaction partner. Evidence regarding one such shared partner highlights a potential for pharmacokinetic interactions, specifically noting a clinically relevant interaction with cyclosporine that necessitates a dose reduction of the shared drug. Which disease is this sha... | pulmonary arterial hypertension | Medium | convergence | {"qa_id":"medium_convergence_05918","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyclosporine and Sorafenib share a common drug interaction partner. Evidence regarding one such shared partner highlights a potential for pharmacokinetic int... | |
medium_convergence_05919 | AFG3L2 and MICU2 are both involved in more than one shared biological process. One of these shared processes involves an entity that, along with MICU1, acts as a main regulator of the mitochondrial Ca(2+)-uniporter (MCU). Which biological process is this shared entity a subclass of (is_a)? | intracellular calcium ion homeostasis | Medium | convergence | {"qa_id":"medium_convergence_05919","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AFG3L2 and MICU2 are both involved in more than one shared biological process. One of these shared processes involves an entity that, along with MICU1, acts ... | |
medium_convergence_05920 | GSPT2 and PPP2CA both interact with a shared protein partner. Experimental evidence regarding this partner notes: 'Similar chromatographic profiles were also observed for the heterotrimer reconstituted from recombinant A alpha, purified B and C, and the native bovine cardiac heterotrimeric holoenzyme.' Which protein is... | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Medium | convergence | {"qa_id":"medium_convergence_05920","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GSPT2 and PPP2CA both interact with a shared protein partner. Experimental evidence regarding this partner notes: 'Similar chromatographic profiles were also... | |
medium_convergence_05922 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE100576) reports a log2 fold change of approximately 1.16 and an adjusted p-value of 0.016. Which disease is associated with this gene as a biomarker? | systemic lupus erythematosus | Medium | convergence | {"qa_id":"medium_convergence_05922","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (stu... | |
medium_convergence_05923 | CSNK2A1 and MSH6 share multiple interacting partners. One such shared partner is described in a study stating: 'In this study, we show that each subunit of the human 9-1-1 complex physically interacts with hMSH2, hMSH3, and hMSH6.' Which protein is encoded by this shared interacting partner? | Cell cycle checkpoint protein RAD1 | Medium | convergence | {"qa_id":"medium_convergence_05923","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and MSH6 share multiple interacting partners. One such shared partner is described in a study stating: 'In this study, we show that each subunit of t... | |
medium_convergence_05924 | LIN54 and LIN9 both interact with a shared protein partner. Evidence regarding one such partner states: 'Using an integrated approach combining proteomics, genomics, and bioinformatic analyses, we identified a complex termed DP, RB-like, E2F, and MuvB (DREAM) that contains mammalian homologs of synMuvB proteins LIN-9, ... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05924","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LIN54 and LIN9 both interact with a shared protein partner. Evidence regarding one such partner states: 'Using an integrated approach combining proteomics, g... | |
medium_convergence_05925 | The biological processes 'positive regulation of defense response to insect' and 'positive regulation of defense response to bacterium' share a common parent process in the ontology hierarchy. Evidence for one of these shared parent processes states: 'Any process that activates or increases the frequency, rate or exten... | response to biotic stimulus | Medium | convergence | {"qa_id":"medium_convergence_05925","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'positive regulation of defense response to insect' and 'positive regulation of defense response to bacterium' share a common parent... | |
medium_convergence_05926 | CDK7 and DDB1 share multiple binding partners. One such shared partner exhibits a counteracting effect on X stabilization that is dependent on its interaction with DDB1. Which protein is encoded by the gene corresponding to this shared partner? | DNA damage-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05926","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK7 and DDB1 share multiple binding partners. One such shared partner exhibits a counteracting effect on X stabilization that is dependent on its interactio... | |
medium_convergence_05927 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene has a log2 fold change of -1.488 and an adjusted p-value of 0.00148. Which protein is encoded by this gene? | MAM domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05927","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_05928 | NFKB1 and CUL1 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Correspondingly, coimmunoprecipitation assays demonstrated that the NF-κB-inhibitory IκBα-p65-p50 complex was intact in VV811-infected cells.' Which protein is encoded by the gene corresponding to... | NF-kappa-B inhibitor alpha | Medium | convergence | {"qa_id":"medium_convergence_05928","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFKB1 and CUL1 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Correspondingly, coimmunoprecipit... | |
medium_convergence_05929 | BMP2 and BMPR1A each interact with more than one shared gene product. Evidence concerning one shared entity reports that a transmembrane serine/threonine kinase is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-... | anemia due to chronic disorder | Medium | convergence | {"qa_id":"medium_convergence_05929","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP2 and BMPR1A each interact with more than one shared gene product. Evidence concerning one shared entity reports that a transmembrane serine/threonine kin... | |
medium_convergence_05930 | PRKN and PSMD1 share multiple interacting partners. One such partner is characterized by evidence stating: 'Here, we showed that Parkin directly interacts with this protein, but did not bind to pathogenic mutants of this protein.' Which protein is encoded by this gene? | Serine/threonine-protein kinase PINK1, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_05930","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and PSMD1 share multiple interacting partners. One such partner is characterized by evidence stating: 'Here, we showed that Parkin directly interacts wi... | |
medium_convergence_05931 | EAF1 and CTR9 both interact with a shared protein component. Evidence regarding this component states: 'Using functionally tagged forms of the Paf1 complex factors, we have determined that, except for the more loosely associated Rtf1, the remaining components stay stably associated with one another in an RNase-resistan... | RNA polymerase-associated protein LEO1 | Medium | convergence | {"qa_id":"medium_convergence_05931","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EAF1 and CTR9 both interact with a shared protein component. Evidence regarding this component states: 'Using functionally tagged forms of the Paf1 complex f... | |
medium_convergence_05932 | CDKN1A and IMMT both interact with a common protein partner. Experimental evidence for this partner includes pull-down assays demonstrating an association with p21, specifically involving the C-terminal part of the p21 protein. Which protein is encoded by this common partner? | Poly [ADP-ribose] polymerase 1 | Medium | convergence | {"qa_id":"medium_convergence_05932","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1A and IMMT both interact with a common protein partner. Experimental evidence for this partner includes pull-down assays demonstrating an association wi... | |
medium_convergence_05933 | The biological processes 'negative regulation of defense response to insect' and 'negative regulation of defense response to bacterium' share a common parent process. Evidence regarding this shared parent process states: 'Any process that stops, prevents or reduces the frequency, rate or extent of defense response to i... | response to biotic stimulus | Medium | convergence | {"qa_id":"medium_convergence_05933","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'negative regulation of defense response to insect' and 'negative regulation of defense response to bacterium' share a common parent... | |
medium_convergence_05934 | TAB2 and TRAF6 share a common interaction partner. Evidence indicates that this shared partner interacts with TAK1, TAB2, TAB3, and TRAF6 under both overexpression and physiological conditions. Which protein is encoded by the gene corresponding to this shared interaction partner? | Cytoplasmic dynein 2 intermediate chain 2 | Medium | convergence | {"qa_id":"medium_convergence_05934","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TAB2 and TRAF6 share a common interaction partner. Evidence indicates that this shared partner interacts with TAK1, TAB2, TAB3, and TRAF6 under both overexpr... | |
medium_convergence_05935 | TAB3 and RIPK1 each interact with more than one shared protein. Evidence concerning one of these shared entities states that a specific adapter molecule recruited the kinases receptor interacting protein (RIP)-1 and RIP3 through its RIP homotypic interaction motif. Which protein is encoded by that entity? | TIR domain-containing adapter molecule 1 | Medium | convergence | {"qa_id":"medium_convergence_05935","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TAB3 and RIPK1 each interact with more than one shared protein. Evidence concerning one of these shared entities states that a specific adapter molecule recr... | |
medium_convergence_05936 | MLH1 and MSH2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Using a yeast two-hybrid assay, we show that these MutL homologues can form heterodimers by interacting with the same amino acid residues of hMLH1, residues 492-742.' Which protein is encoded by t... | Mismatch repair endonuclease PMS2 | Medium | convergence | {"qa_id":"medium_convergence_05936","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MLH1 and MSH2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Using a yeast two-hybrid assay, w... | |
medium_convergence_05937 | Human alphaherpesvirus 3 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene has a log2 fold change of -1.429 and an adjusted p-value of 2.607e-05. Which protein is encoded by this gene? | Cell division cycle-associated 7-like protein | Medium | convergence | {"qa_id":"medium_convergence_05937","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicat... | |
medium_convergence_05938 | HDAC1 and TCF7L2 both interact with a common protein partner. Evidence indicates that interactions between Groucho and this specific partner are enhanced by the sumoylation of Groucho, a process mediated by the SUMO-interaction motif of the partner. Which disease is associated with this protein partner? | fibrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_05938","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and TCF7L2 both interact with a common protein partner. Evidence indicates that interactions between Groucho and this specific partner are enhanced by ... | |
medium_convergence_05939 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 1.744 and an adjusted p-value of 0.00716. Which protein is encoded by this gene? | Histone H2B type 1-D | Medium | convergence | {"qa_id":"medium_convergence_05939","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (stud... | |
medium_convergence_05940 | BRD8 and ACTL6A each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Yeast two-hybrid screening and subsequent immunoprecipitation analysis identified bromodomain containing 8 (BRD8) as an [entity]-interacting protein.' Which disease is associated with that entity? | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05940","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD8 and ACTL6A each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Yeast two-hybrid screening and subsequent im... | |
medium_convergence_05941 | Human immunodeficiency virus 1 and Dengue virus both upregulate a specific gene. Evidence for this shared target indicates a log2 fold change of 2.579 and an adjusted p-value of 0.01823. Which protein is encoded by this gene? | Histone H4 | Medium | convergence | {"qa_id":"medium_convergence_05941","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human immunodeficiency virus 1 and Dengue virus both upregulate a specific gene. Evidence for this shared target indicates a log2 fold change of 2.579 and an... | |
medium_convergence_05943 | STUB1 and CRK both interact with a specific shared protein. Experimental evidence indicates that both exogenously expressed and endogenous CHIP coprecipitate with this kinase. Which protein is encoded by this shared entity? | Receptor tyrosine-protein kinase erbB-2 | Medium | convergence | {"qa_id":"medium_convergence_05943","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and CRK both interact with a specific shared protein. Experimental evidence indicates that both exogenously expressed and endogenous CHIP coprecipitate... | |
medium_convergence_05944 | Desmoplakin (DSP) and Junction Plakoglobin (JUP) both interact with a specific shared protein partner. Experimental evidence indicates that in extracts from HaCaT cells, distinct soluble complexes containing this shared partner and desmoplakin I (DPI) have been identified by co-immunoprecipitation and sucrose density f... | Plakophilin-1 | Medium | convergence | {"qa_id":"medium_convergence_05944","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Desmoplakin (DSP) and Junction Plakoglobin (JUP) both interact with a specific shared protein partner. Experimental evidence indicates that in extracts from ... | |
medium_convergence_05945 | CREBBP and PSMD4 share multiple interacting partners. One such shared partner is described by evidence stating: 'Additionally, a human homolog of RAD23 was shown to interact in vitro and in vivo with p300 segments harboring C/H1 domain.' Which protein is connected to this shared entity through the 'encodes' relation? | Lysine-specific demethylase RAD23A | Medium | convergence | {"qa_id":"medium_convergence_05945","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and PSMD4 share multiple interacting partners. One such shared partner is described by evidence stating: 'Additionally, a human homolog of RAD23 was s... | |
medium_convergence_05946 | SMAD3 and POU5F1 share multiple binding partners. One such shared partner is described in evidence stating: 'Using experimental high-resolution structure determination, followed by model building and experimental validation, we found that Oct4 and this partner were able to dimerize onto DNA in distinct conformational a... | Transcription factor SOX-2 | Medium | convergence | {"qa_id":"medium_convergence_05946","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD3 and POU5F1 share multiple binding partners. One such shared partner is described in evidence stating: 'Using experimental high-resolution structure det... | |
medium_convergence_05948 | COPB1 and BET1L both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which protein is encoded by the gene correspond... | Coatomer subunit gamma-1 | Medium | convergence | {"qa_id":"medium_convergence_05948","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and BET1L both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatome... | |
medium_convergence_05949 | EGFR and SH3KBP1 share a common interaction partner. Evidence for this shared partner includes the statement: 'In support of the possibility that this may be a direct interaction, we show that the two receptors can be coimmunoprecipitated from untransfected Hs27 fibroblasts and from COS-7 cells.' Which protein is encod... | Platelet-derived growth factor receptor beta | Medium | convergence | {"qa_id":"medium_convergence_05949","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and SH3KBP1 share a common interaction partner. Evidence for this shared partner includes the statement: 'In support of the possibility that this may be... | |
medium_convergence_05950 | SMAD1 and SMAD2 each interact with a shared protein partner. Experimental evidence indicates that this partner interacts with receptor-activated Smads (R-Smads), specifically including Smad1, Smad2, and Smad3, but not Smad4. Which protein is encoded by the gene corresponding to this shared partner? | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_05950","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD1 and SMAD2 each interact with a shared protein partner. Experimental evidence indicates that this partner interacts with receptor-activated Smads (R-Sma... | |
medium_convergence_05951 | FGF1 and FGF10 both interact with a specific receptor protein. Experimental evidence indicates that a complex has been crystallized between human FGF1 and a two-domain extracellular fragment of this receptor. Which protein is encoded by the gene corresponding to this receptor? | Fibroblast growth factor receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_05951","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF1 and FGF10 both interact with a specific receptor protein. Experimental evidence indicates that a complex has been crystallized between human FGF1 and a ... | |
medium_convergence_05953 | LTBP1 and ARRB2 each interact with more than one shared protein. Evidence concerning one shared entity reports that TGF-beta1 associates with the 3rd 8-Cys repeat of LTBP-1 via LAP. Which protein is connected to that entity through the 'encodes' relationship? | Transforming growth factor beta-1 proprotein | Medium | convergence | {"qa_id":"medium_convergence_05953","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LTBP1 and ARRB2 each interact with more than one shared protein. Evidence concerning one shared entity reports that TGF-beta1 associates with the 3rd 8-Cys r... | |
medium_convergence_05954 | HDAC5 and the androgen receptor (AR) both interact with a specific corepressor protein. A study highlights that a repression domain (RD), conserved in this corepressor and SMRT, represses transcription by interacting directly with class II HDAC4 and HDAC5. Based on this evidence identifying the shared interaction partn... | Nuclear receptor corepressor 1 | Medium | convergence | {"qa_id":"medium_convergence_05954","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC5 and the androgen receptor (AR) both interact with a specific corepressor protein. A study highlights that a repression domain (RD), conserved in this c... | |
medium_convergence_05955 | DHX9 and GRSF1 both interact with a common protein partner. Evidence indicates that this shared partner directly interacts with DHX9 via its Tudor domain. Which protein is encoded by this shared partner? | Tudor domain-containing protein 3 | Medium | convergence | {"qa_id":"medium_convergence_05955","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DHX9 and GRSF1 both interact with a common protein partner. Evidence indicates that this shared partner directly interacts with DHX9 via its Tudor domain. Wh... | |
medium_convergence_05956 | CEBPA and ESR2 both interact with a shared protein entity. Evidence regarding one such shared entity states: 'The protein-protein interaction of C/EBPalpha and ASC-2 was detected by coimmunoprecipitation during granulocyte differentiation.' Which protein is encoded by the gene corresponding to this shared entity? | Nuclear receptor coactivator 6 | Medium | convergence | {"qa_id":"medium_convergence_05956","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPA and ESR2 both interact with a shared protein entity. Evidence regarding one such shared entity states: 'The protein-protein interaction of C/EBPalpha a... | |
medium_convergence_05957 | SIMC1 and PML both interact with a specific shared protein. Experimental evidence indicates that this shared protein was isolated from the proteomic environment of the SMC5/6 complex within polyomavirus large T antigen (LT)-induced subnuclear compartments. Which protein is encoded by the gene corresponding to this shar... | Structural maintenance of chromosomes protein 6 | Medium | convergence | {"qa_id":"medium_convergence_05957","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIMC1 and PML both interact with a specific shared protein. Experimental evidence indicates that this shared protein was isolated from the proteomic environm... | |
medium_convergence_05958 | ARRB2 and PDYN each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In vitro data from glutathione-S-transferase pull-down assay showed that the carboxyl terminus (CT) and the third intracellular loop (I3L) of DOR are both capable of and either domain is sufficient for bindin... | common cold | Medium | convergence | {"qa_id":"medium_convergence_05958","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARRB2 and PDYN each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In vitro data from glutathione-S-transferase ... | |
medium_convergence_05959 | Human alphaherpesvirus 3 and Human betaherpesvirus 5 both downregulate a specific gene. Evidence for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.31 and an adjusted p-value of approximately 4.14e-06. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_05959","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Human betaherpesvirus 5 both downregulate a specific gene. Evidence for this gene in a melanoma cell line (study GSE136586) repo... | |
medium_convergence_05960 | Human betaherpesvirus 5 and Dengue virus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of -2.212 and an adjusted p-value of 0.003417. Which protein is encoded by this gene? | Filamin A-interacting protein 1-like | Medium | convergence | {"qa_id":"medium_convergence_05960","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Dengue virus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 ... | |
medium_convergence_05961 | FOS and JUN each interact with more than one shared gene product. Evidence concerning one such shared entity states: 'Here, we demonstrate interaction between c-Jun and c-Fos with Cbfa/Runt proteins.' Which protein is encoded by that entity? | Runt-related transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_05961","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOS and JUN each interact with more than one shared gene product. Evidence concerning one such shared entity states: 'Here, we demonstrate interaction betwee... | |
medium_convergence_05962 | HDAC6 and BCAP31 share multiple protein interaction partners. One such shared partner is described in evidence stating: 'We show that BAP31 specifically associates with nonmuscle myosin heavy chain B and nonmuscle gamma-actin, two components of the cytoskeleton actomyosin complex.' Which protein is encoded by the gene ... | Myosin-10 | Medium | convergence | {"qa_id":"medium_convergence_05962","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and BCAP31 share multiple protein interaction partners. One such shared partner is described in evidence stating: 'We show that BAP31 specifically asso... | |
medium_convergence_05963 | EIF2S3 and EIF3F share multiple binding partners. One such partner is identified by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which cellular component is this specific partner located in? | eukaryotic translation initiation factor 3 complex | Medium | convergence | {"qa_id":"medium_convergence_05963","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF2S3 and EIF3F share multiple binding partners. One such partner is identified by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 ... | |
medium_convergence_05964 | ANAPC13 and BUB1B each interact with more than one shared protein. Evidence concerning one shared entity reports that purified BubR1 binds to recombinant versions of this entity and that this interaction is direct. Which protein is encoded by the gene corresponding to that entity? | Cell division cycle protein 20 homolog | Medium | convergence | {"qa_id":"medium_convergence_05964","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC13 and BUB1B each interact with more than one shared protein. Evidence concerning one shared entity reports that purified BubR1 binds to recombinant ver... | |
medium_convergence_05965 | EGFR and FGFR1 share common interaction partners. One such shared partner has been experimentally shown to interact with both Cbl and EGFR. Which cell type is enriched for this specific shared partner? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05965","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and FGFR1 share common interaction partners. One such shared partner has been experimentally shown to interact with both Cbl and EGFR. Which cell type i... | |
medium_convergence_05966 | ACTR3 and CDC42 share a common binding partner. Experimental evidence regarding this partner indicates that mutations such as V42A and L174A in CDC42 cause large, selective changes in binding to specific CRIB effectors. Specifically, neither mutation alters PAK binding, both severely disrupt ACK binding, and only the L... | Actin nucleation-promoting factor WAS | Medium | convergence | {"qa_id":"medium_convergence_05966","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR3 and CDC42 share a common binding partner. Experimental evidence regarding this partner indicates that mutations such as V42A and L174A in CDC42 cause l... | |
medium_convergence_05967 | AKT1 and FGFR1 share a common interacting partner. Evidence indicates that the C-terminal region of a protein kinase C-related kinase, specifically amino acids 862 to 908, binds to Akt in yeast and mammalian cells. Which cell type is enriched for this shared interacting partner? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05967","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and FGFR1 share a common interacting partner. Evidence indicates that the C-terminal region of a protein kinase C-related kinase, specifically amino aci... | |
medium_convergence_05968 | DTX3 and PRKN (Parkin) both interact with a specific ubiquitin-conjugating enzyme. Evidence indicates that Parkin binds to this E2 ubiquitin-conjugating enzyme through its C-terminal ring-finger. Which protein is encoded by the gene corresponding to this interacting entity? | Ubiquitin/ISG15-conjugating enzyme E2 L6 | Medium | convergence | {"qa_id":"medium_convergence_05968","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DTX3 and PRKN (Parkin) both interact with a specific ubiquitin-conjugating enzyme. Evidence indicates that Parkin binds to this E2 ubiquitin-conjugating enzy... | |
medium_convergence_05969 | HDAC1 and ARID4B both interact with a specific protein that serves as a component of the human histone deacetylase complex. This complex is described as including Sin3, the histone deacetylases HDAC1 and HDAC2, histone binding proteins RbAp46 and RbAp48, and other polypeptides. Which gene encodes this specific protein? | Histone deacetylase complex subunit SAP30 | Medium | convergence | {"qa_id":"medium_convergence_05969","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and ARID4B both interact with a specific protein that serves as a component of the human histone deacetylase complex. This complex is described as incl... | |
medium_convergence_05970 | PHB2 and DPP4 share a common interacting partner. Experimental evidence involving Co-immunoprecipitation (co-IP) of a known stoichiometric binding partner of dipeptidyl-peptidase IV corroborates the identification of this shared entity. Which protein is encoded by this shared interacting partner? | Prolyl endopeptidase FAP | Medium | convergence | {"qa_id":"medium_convergence_05970","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PHB2 and DPP4 share a common interacting partner. Experimental evidence involving Co-immunoprecipitation (co-IP) of a known stoichiometric binding partner of... | |
medium_convergence_05971 | PSMB1 and PSMC5 both interact with a common protein partner. Experimental evidence regarding this partner states: 'By means of chemical cross-linking, immunoprecipitation, and blotting, we have determined that the ATPases are organized in the order S6-S6'-S10b-S8-S4-S7.' Which protein is encoded by this shared partner? | 26S proteasome regulatory subunit 10B | Medium | convergence | {"qa_id":"medium_convergence_05971","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMB1 and PSMC5 both interact with a common protein partner. Experimental evidence regarding this partner states: 'By means of chemical cross-linking, immuno... | |
medium_convergence_05972 | Both Human betaherpesvirus 5 and Dengue virus have been shown to downregulate a specific gene. Experimental data from a study on foreskin fibroblast cell lines (GSE111036) indicates that this gene exhibits a log2 fold change of -1.917 and an adjusted p-value of 0.04604. Which cellular component is this gene located in? | mitochondrion | Medium | convergence | {"qa_id":"medium_convergence_05972","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Dengue virus have been shown to downregulate a specific gene. Experimental data from a study on foreskin fibroblast cell lin... | |
medium_convergence_05973 | CENPW and MIS18A both interact with a shared protein partner. Evidence regarding this partner states: 'We report here that a specific arrangement of Yippee domains in a human Mis18α:Mis18β 4:2 hexamer binds two copies of M18BP1 through M18BP1's 140 N-terminal residues.' Which protein is encoded by the gene correspondin... | Protein Mis18-beta | Medium | convergence | {"qa_id":"medium_convergence_05973","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPW and MIS18A both interact with a shared protein partner. Evidence regarding this partner states: 'We report here that a specific arrangement of Yippee d... | |
medium_convergence_05974 | KAT5 and HIST1H1B both interact with a specific protein. Evidence indicates that this protein is chromobox homolog 8, a Polycomb Group protein that interacts with MLL-AF9 and TIP60 and is required for MLL-AF9-induced transcriptional activation and leukemogenesis. Which gene encodes this protein? | Chromobox protein homolog 8 | Medium | convergence | {"qa_id":"medium_convergence_05974","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and HIST1H1B both interact with a specific protein. Evidence indicates that this protein is chromobox homolog 8, a Polycomb Group protein that interacts... | |
medium_convergence_05975 | HIPK2 and TP53 both interact with a shared protein. Evidence indicates that upon DNA damage, HIPK2 site-specifically phosphorylates this shared protein, an event that terminates the protein's function in degrading HIPK2 and triggers its re-localization to the cell nucleus. Which protein is encoded by the gene correspon... | DAZ-associated protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05975","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIPK2 and TP53 both interact with a shared protein. Evidence indicates that upon DNA damage, HIPK2 site-specifically phosphorylates this shared protein, an e... | |
medium_convergence_05976 | Both ATR and BLM interact with a specific shared protein. Contextual evidence indicates that this protein, a shared interaction partner of ATR and Rad9, interacts with the checkpoint proteins ATR and Rad9. Which disease is associated with this entity via a biomarker relationship? | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05976","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ATR and BLM interact with a specific shared protein. Contextual evidence indicates that this protein, a shared interaction partner of ATR and Rad9, inte... | |
medium_convergence_05977 | ESR1 and HSP90AA1 share multiple interacting partners. One specific shared partner is characterized by evidence stating it directly interacts with the ligand binding domain of ER and is recruited to the proximal promoter regions of ER target genes upon gene induction. Which cell type is this specific partner enriched i... | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_05977","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HSP90AA1 share multiple interacting partners. One specific shared partner is characterized by evidence stating it directly interacts with the ligand... | |
medium_convergence_05978 | YAP1 and AMOT share interaction partners. One such shared partner is described in evidence stating that it interacts with yes-associated protein 1 (YAP1), a member of the hippo signaling pathway. Which protein is encoded by this shared partner? | Tyrosine-protein phosphatase non-receptor type 14 | Medium | convergence | {"qa_id":"medium_convergence_05978","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and AMOT share interaction partners. One such shared partner is described in evidence stating that it interacts with yes-associated protein 1 (YAP1), a ... |
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