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medium_convergence_06995 | FAAP20 and FANCE each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In normal cells, HA-tagged FANCE protein coimmunoprecipitates with FANCA, FANCC, and this shared protein but not with FANCD2.' Which disease is connected to this shared protein through genomic alterations? | ovarian neoplasm | Medium | convergence | {"qa_id":"medium_convergence_06995","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAAP20 and FANCE each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In normal cells, HA-tagged FANCE protein co... | |
medium_convergence_06996 | EP300 and HIST1H4A share multiple interacting partners. One such partner is implicated in a study describing the solution NMR structure of MLL4-PHD6 in complex with a H4K16ac peptide, which reveals mechanistic features underlying the recognition of H4K16ac. Which protein encodes this specific interacting partner? | Histone-lysine N-methyltransferase 2C | Medium | convergence | {"qa_id":"medium_convergence_06996","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and HIST1H4A share multiple interacting partners. One such partner is implicated in a study describing the solution NMR structure of MLL4-PHD6 in compl... | |
medium_convergence_06997 | DVL2 and RAC1 share multiple interacting partners. One such shared partner is described in a mechanism study as interacting with DVL2, an important upstream regulator for beta-catenin/TCF signaling, and activating this pathway. Which protein is encoded by this shared partner? | Ras-related protein Rap-1b | Medium | convergence | {"qa_id":"medium_convergence_06997","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DVL2 and RAC1 share multiple interacting partners. One such shared partner is described in a mechanism study as interacting with DVL2, an important upstream ... | |
medium_convergence_06998 | STUB1 and GSK3B both interact with a specific shared protein. Evidence indicates that CHIP binds directly to an intrinsically disordered domain in the central region of this protein (residues 106-140), a site sufficient to form a stable complex with CHIP in cells and compete in trans with the full-length protein, there... | Interferon regulatory factor 1 | Medium | convergence | {"qa_id":"medium_convergence_06998","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and GSK3B both interact with a specific shared protein. Evidence indicates that CHIP binds directly to an intrinsically disordered domain in the centra... | |
medium_convergence_06999 | CHD4 and DAXX both interact with a specific shared protein. Evidence regarding this shared entity states: 'We discovered that DNMTs and the core components of the NuRD (Mi-2/nucleosome remodeling and deacetylase) nucleosome remodeling complex, chromo domain helicase DNA-binding protein 4 (CHD4) and histone deacetylase ... | DNA (cytosine-5)-methyltransferase 1 | Medium | convergence | {"qa_id":"medium_convergence_06999","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and DAXX both interact with a specific shared protein. Evidence regarding this shared entity states: 'We discovered that DNMTs and the core components o... | |
medium_convergence_07000 | CDK2 and HSP90AA1 share multiple interacting partners. One of these shared partners has been identified through yeast two-hybrid assays and functional analyses as a specific E3 ubiquitin ligase that regulates the degradation of CDK2. Which gene interacts with this specific E3 ubiquitin ligase? | TOX | Medium | convergence | {"qa_id":"medium_convergence_07000","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and HSP90AA1 share multiple interacting partners. One of these shared partners has been identified through yeast two-hybrid assays and functional analys... | |
medium_convergence_07001 | NEDD4L and TSG101 both interact with a specific protein complex component. Evidence indicates that hepatocellular carcinoma related protein 1 interacts with this component, along with Tsg101, hVps28, and their upstream regulator Hrs. Which protein is encoded by the gene corresponding to this interacting component? | Vacuolar protein sorting-associated protein 37A | Medium | convergence | {"qa_id":"medium_convergence_07001","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and TSG101 both interact with a specific protein complex component. Evidence indicates that hepatocellular carcinoma related protein 1 interacts with ... | |
medium_convergence_07003 | ALK and KRAS both interact with a specific protein. Evidence from LC/MS-MS analysis indicates that this protein, along with SHP2, was identified and validated as an interactor of ALK in neuroblastoma (NB) cells. Which protein is encoded by the gene corresponding to this shared interactor? | Inactive tyrosine-protein kinase PEAK1 | Medium | convergence | {"qa_id":"medium_convergence_07003","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALK and KRAS both interact with a specific protein. Evidence from LC/MS-MS analysis indicates that this protein, along with SHP2, was identified and validate... | |
medium_convergence_07004 | CHD4 and KCNA3 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Moreover, Kv1.3 is shown to form a complex with the upstream binding factor 1 in the nucleus.' Which protein is connected to that entity through the 'encodes' relationship? | Nucleolar transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_07004","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and KCNA3 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Moreover, Kv1.3 is shown to form a compl... | |
medium_convergence_07005 | CSNK1E and BTRC both interact with a shared protein. Evidence indicates that SUMO2 conjugation facilitates the interaction of this shared protein with β-TrCP, leading to its proteasomal degradation. Which cellular component is this shared protein located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_07005","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1E and BTRC both interact with a shared protein. Evidence indicates that SUMO2 conjugation facilitates the interaction of this shared protein with β-TrCP... | |
medium_convergence_07006 | GRIN1 and GRIN2B both interact with a specific protein partner. Experimental evidence indicates that immunoprecipitation using an anti-NR1 antibody shows this partner (NR3A) is predominantly associated with NR1 in the postnatal day 10 rat cortex (80 +/- 8%), a level that decreases by half (38 +/- 4%) in the adult rat c... | Glutamate receptor ionotropic, NMDA 3A | Medium | convergence | {"qa_id":"medium_convergence_07006","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRIN1 and GRIN2B both interact with a specific protein partner. Experimental evidence indicates that immunoprecipitation using an anti-NR1 antibody shows thi... | |
medium_convergence_07008 | Morphine and Tripelennamine both interact with a specific drug. Evidence regarding this drug states: 'Among patients receiving prescription opioids, after controlling for all confounding factors, concomitant treatment with Z-drugs was associated with a substantial relative increase in the risk of overdose.' What diseas... | insomnia | Medium | convergence | {"qa_id":"medium_convergence_07008","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Tripelennamine both interact with a specific drug. Evidence regarding this drug states: 'Among patients receiving prescription opioids, after co... | |
medium_convergence_07009 | Both Human respirovirus 3 and Enterovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of approximately 1.229 and an adjusted p-value of 0.04727. Which disease is associated with this gene... | epilepsy | Medium | convergence | {"qa_id":"medium_convergence_07009","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Enterovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a non-small cell lung adenocar... | |
medium_convergence_07010 | AMOT and LATS2 share interaction partners. One such shared partner is described in evidence stating: 'We found that, by binding LATS1/2, this protein, and YAP, angiomotins function as a scaffold that connects LATS1/2 to both its activator this protein-MST1 and its target YAP.' Which protein is encoded by this shared en... | Protein salvador homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_07010","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMOT and LATS2 share interaction partners. One such shared partner is described in evidence stating: 'We found that, by binding LATS1/2, this protein, and YA... | |
medium_convergence_07011 | PDIA3 and TAP1 both interact with a shared protein partner. Evidence regarding this partner indicates that photolabeling experiments with 8-azido-ATP demonstrate a cooperative interaction between two nucleotide-binding domains (NBDs) that can be stimulated by peptide. Which disease is associated with this protein throu... | psoriasis | Medium | convergence | {"qa_id":"medium_convergence_07011","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDIA3 and TAP1 both interact with a shared protein partner. Evidence regarding this partner indicates that photolabeling experiments with 8-azido-ATP demonst... | |
medium_convergence_07012 | H2AFZ and MYCN share multiple interacting partners. One such shared partner is supported by evidence stating: 'The interaction between a specific protein and n-Myc was validated by pull-down experiments.' Which protein is encoded by this specific shared partner? | YEATS domain-containing protein 4 | Medium | convergence | {"qa_id":"medium_convergence_07012","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AFZ and MYCN share multiple interacting partners. One such shared partner is supported by evidence stating: 'The interaction between a specific protein and... | |
medium_convergence_07013 | Both Influenza A virus and Zaire ebolavirus are known to downregulate a specific host gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE106279) reports a log2 fold change of approximately -1.208 and an adjusted p-value of 1.278e-05. Which protein does this downregulated g... | SH3GL2 | Medium | convergence | {"qa_id":"medium_convergence_07013","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Zaire ebolavirus are known to downregulate a specific host gene. Experimental data for this gene in a non-small cell lung adenocar... | |
medium_convergence_07014 | CSNK2A1 and JAK3 both interact with a shared gene product. Experimental evidence indicates that casein kinase 2 (CKII) interacts with immobilized NAP-II and phosphorylates both NAP-2 and nucleosome assembly protein 1 (NAP-1) in vitro. Which disease is associated with this shared entity via a biomarker relationship? | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_07014","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and JAK3 both interact with a shared gene product. Experimental evidence indicates that casein kinase 2 (CKII) interacts with immobilized NAP-II and ... | |
medium_convergence_07015 | HOXA1 and TIFAB are both involved in more than one shared biological process. Evidence concerning one of these shared processes reports a phenotype that includes horizontal gaze abnormalities, deafness, facial weakness, hypoventilation, vascular malformations of the internal carotid arteries and cardiac outflow tract, ... | internal ear | Medium | convergence | {"qa_id":"medium_convergence_07015","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HOXA1 and TIFAB are both involved in more than one shared biological process. Evidence concerning one of these shared processes reports a phenotype that incl... | |
medium_convergence_07017 | EP300 and LIPA both interact with a specific nuclear receptor protein. Evidence indicates that the E region of this protein's alpha1 isoform interacts with p300, a cofactor functioning as a coactivator in nuclear receptor and MyoD-mediated transactivation. Which gene encodes this protein? | Nuclear receptor ROR-alpha | Medium | convergence | {"qa_id":"medium_convergence_07017","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and LIPA both interact with a specific nuclear receptor protein. Evidence indicates that the E region of this protein's alpha1 isoform interacts with p... | |
medium_convergence_07019 | CDKN1A and COPS4 share a common interacting partner. Evidence indicates that this shared partner functions as the substrate recruiting factor for p21 within the CRL4 ubiquitin ligase complex. Which protein is encoded by this shared interacting partner? | Denticleless protein homolog | Medium | convergence | {"qa_id":"medium_convergence_07019","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1A and COPS4 share a common interacting partner. Evidence indicates that this shared partner functions as the substrate recruiting factor for p21 within ... | |
medium_convergence_07020 | GRSF1 and MAPK1 both interact with a shared protein. Evidence regarding this shared protein states: 'In this report we show that RSK1 and ERK1/2 form a complex in quiescent HEK293 cells that transiently dissociates upon mitogen stimulation.' Which cell type is this shared protein enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_07020","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRSF1 and MAPK1 both interact with a shared protein. Evidence regarding this shared protein states: 'In this report we show that RSK1 and ERK1/2 form a compl... | |
medium_convergence_07021 | GNAT1 and GNB2 each interact with multiple shared G-protein gamma subunits. One such shared subunit is implicated in a process where PhLP1 plays a vital role in the assembly of Ggamma2 with all four Gbeta1-4 subunits and in the assembly of Gbeta2 with all twelve Ggamma subunits, without affecting the specificity of the... | signal transduction | Medium | convergence | {"qa_id":"medium_convergence_07021","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAT1 and GNB2 each interact with multiple shared G-protein gamma subunits. One such shared subunit is implicated in a process where PhLP1 plays a vital role... | |
medium_convergence_07023 | BRD4 and KCNA3 share common interaction partners. One such shared partner is implicated in a specific nuclear event: Kv1.3 is shown to form a complex with this entity in the nucleus. Which protein is encoded by this shared interaction partner? | Nucleolar transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_07023","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and KCNA3 share common interaction partners. One such shared partner is implicated in a specific nuclear event: Kv1.3 is shown to form a complex with th... | |
medium_convergence_07024 | HUWE1 and TP53 share multiple interacting partners. One such partner is described by the following evidence: 'Here, we demonstrate that this protein directly interacts with p53 via the p53 DNA-binding domain.' Which disease is associated with this specific entity? | diarrhea 14, congenital | Medium | convergence | {"qa_id":"medium_convergence_07024","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and TP53 share multiple interacting partners. One such partner is described by the following evidence: 'Here, we demonstrate that this protein directly... | |
medium_convergence_07025 | PEX2 and CBL both interact with a specific ubiquitin-conjugating enzyme. Evidence indicates that this enzyme, along with members of the Ube2e family and Ube2n/2v1, catalyzes the autoubiquitination of the Cbl protein and mediates the ubiquitination of EGFR and SYK substrates. Which protein is encoded by the gene corresp... | Ubiquitin-conjugating enzyme E2 D3 | Medium | convergence | {"qa_id":"medium_convergence_07025","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PEX2 and CBL both interact with a specific ubiquitin-conjugating enzyme. Evidence indicates that this enzyme, along with members of the Ube2e family and Ube2... | |
medium_convergence_07026 | STK38 and ANKRD52 both interact with a specific protein. Experimental evidence indicates that this protein, along with hMOB2, binds to the N-terminal region of NDR1. Which protein is encoded by the gene corresponding to this interacting partner? | MOB kinase activator 1A | Medium | convergence | {"qa_id":"medium_convergence_07026","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STK38 and ANKRD52 both interact with a specific protein. Experimental evidence indicates that this protein, along with hMOB2, binds to the N-terminal region ... | |
medium_convergence_07027 | YAP1 and ADRB2 share a common interacting partner. Experimental evidence confirms that this specific partner, along with ARRDC1, interacts with YAP1, whereas other alpha-arrestin family proteins do not. Which protein is encoded by this shared interacting partner? | Arrestin domain-containing protein 3 | Medium | convergence | {"qa_id":"medium_convergence_07027","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and ADRB2 share a common interacting partner. Experimental evidence confirms that this specific partner, along with ARRDC1, interacts with YAP1, whereas... | |
medium_convergence_07028 | Human alphaherpesvirus 1 and Human orthopneumovirus both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 2.045 and an adjusted p-value of 0.02199. Which protein is encoded by this gene? | Suppressor of cytokine signaling 3 | Medium | convergence | {"qa_id":"medium_convergence_07028","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human orthopneumovirus both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study... | |
medium_convergence_07029 | AEBP2 and E2F6 both interact with a shared protein partner. Experimental evidence indicates that this partner co-elutes with DP1, EPC1, and Sin3B in affinity purification assays, suggesting the formation of a novel complex in vivo within both normal and transformed human cell lines. Which protein is encoded by this sha... | Histone-lysine N-methyltransferase EZH2 | Medium | convergence | {"qa_id":"medium_convergence_07029","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AEBP2 and E2F6 both interact with a shared protein partner. Experimental evidence indicates that this partner co-elutes with DP1, EPC1, and Sin3B in affinity... | |
medium_convergence_07030 | POLA2 and POLD1 each share a binding partner. Evidence concerning one such shared partner states: 'These assays revealed that p12 interacts with p125 as well as p50.' Which protein is encoded by that shared partner? | DNA polymerase delta subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_07030","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLA2 and POLD1 each share a binding partner. Evidence concerning one such shared partner states: 'These assays revealed that p12 interacts with p125 as well... | |
medium_convergence_07031 | Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.231 and an adjusted p-value of 0.01941. Which disease is therapeutically associated with this gene? | hypothyroidism | Medium | convergence | {"qa_id":"medium_convergence_07031","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Experimental data for this gene in a monocytic leuke... | |
medium_convergence_07032 | WDR5 and HDAC2 share multiple interacting partners. One such partner is characterized by evidence stating that Atrophin-2 selectively binds histone deacetylase 1/2 (HDAC1/2) through its ELM2/SANT domains. Which cellular component is this specific partner located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_07032","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WDR5 and HDAC2 share multiple interacting partners. One such partner is characterized by evidence stating that Atrophin-2 selectively binds histone deacetyla... | |
medium_convergence_07033 | EHMT2 and CTBP1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'In addition, the shared entity also interacts with another histone methyltransferase, G9a, but not with SET9.' Which protein is encoded by this shared entity? | Histone-lysine N-methyltransferase MECOM | Medium | convergence | {"qa_id":"medium_convergence_07033","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and CTBP1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'In addition, the shared entity also interacts wi... | |
medium_convergence_07034 | EP300 and ERG share a common interaction partner. Evidence indicates that this shared partner interacts with CBP in a phosphorylation-enhanced manner in vivo. Which protein is encoded by this shared interaction partner? | Protein C-ets-2 | Medium | convergence | {"qa_id":"medium_convergence_07034","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and ERG share a common interaction partner. Evidence indicates that this shared partner interacts with CBP in a phosphorylation-enhanced manner in vivo... | |
medium_convergence_07035 | HUWE1 and PSMC5 both interact with a shared protein. Evidence indicates that HUWE1, an E3 ubiquitin ligase, acts as a binding partner and regulator of this shared protein's function. Which disease is associated with this shared protein through genomic alterations? | Noonan syndrome | Medium | convergence | {"qa_id":"medium_convergence_07035","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and PSMC5 both interact with a shared protein. Evidence indicates that HUWE1, an E3 ubiquitin ligase, acts as a binding partner and regulator of this s... | |
medium_convergence_07036 | BMI1 and PCGF5 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The RING domains of both proteins mediate their association and subsequent stabilization.' Which protein is connected to that shared partner through the 'encodes' relationship? | E3 ubiquitin-protein ligase RING2 | Medium | convergence | {"qa_id":"medium_convergence_07036","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMI1 and PCGF5 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The RING domains of both pr... | |
medium_convergence_07037 | CBX3 and CBX5 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'In a yeast two-hybrid screen, the nucleoplasmic domain of a specific inner nuclear membrane integral protein, associated with two human polypeptides homologous to Drosophila HP1, a heterochromatin protein involve... | regressive spondylometaphyseal dysplasia | Medium | convergence | {"qa_id":"medium_convergence_07037","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and CBX5 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'In a yeast two-hybrid screen, the nucleoplasmic d... | |
medium_convergence_07038 | CDK7 and EAF2 both interact with a shared protein partner. Experimental evidence for one such partner states: 'Using specific antibodies generated to EAF2, we coimmunoprecipitated [the partner] and EAF2 from multiple cell lines.' Which disease is associated with this specific protein partner? | myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_07038","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK7 and EAF2 both interact with a shared protein partner. Experimental evidence for one such partner states: 'Using specific antibodies generated to EAF2, w... | |
medium_convergence_07039 | SIN3A and HDAC1 share a common interacting partner. Evidence indicates that this partner interacts with histone methyltransferase (PRC2) and histone deacetylase (NuRD and SIN3A) complexes through their common subunit, RBBP4/7. Which protein is encoded by this shared interacting partner? | BCL11 transcription factor A | Medium | convergence | {"qa_id":"medium_convergence_07039","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and HDAC1 share a common interacting partner. Evidence indicates that this partner interacts with histone methyltransferase (PRC2) and histone deacetyl... | |
medium_convergence_07040 | Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes shows a log2 fold change of approximately 3.06 and an adjusted p-value of 0.028. Which protein is encoded by this gene? | Interferon alpha-1 | Medium | convergence | {"qa_id":"medium_convergence_07040","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes shows a log2 fold change of app... | |
medium_convergence_07041 | CDK8 and KDM6A both interact with a specific protein. Evidence indicates that UTX interacts with the C-terminal region of this shared interaction partner. Which protein, encoded by the gene corresponding to this shared interaction partner, is linked to the entity described in the evidence? | Histone-lysine N-methyltransferase 2D | Medium | convergence | {"qa_id":"medium_convergence_07041","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK8 and KDM6A both interact with a specific protein. Evidence indicates that UTX interacts with the C-terminal region of this shared interaction partner. Wh... | |
medium_convergence_07042 | EIF2B4 and EIF2B2 both interact with a common protein partner. Experimental evidence indicates that removing either the N- or C-terminal conserved domains of this partner leads to a significant loss of GEF activity and disrupts its interaction with the alpha, gamma, and delta subunits of eIF2B. Which disease is associa... | leukoencephalopathy with vanishing white matter 5 | Medium | convergence | {"qa_id":"medium_convergence_07042","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF2B4 and EIF2B2 both interact with a common protein partner. Experimental evidence indicates that removing either the N- or C-terminal conserved domains of... | |
medium_convergence_07043 | Both Pegivirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for this gene, derived from peripheral blood mononuclear cells in study GSE131504, reports a log2 fold change of approximately 1.090 and an adjusted p-value of 0.03858. W... | Cytochrome b5 reductase 4 | Medium | convergence | {"qa_id":"medium_convergence_07043","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Pegivirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for thi... | |
medium_convergence_07044 | Dengue virus and Cardiovirus A both downregulate a specific gene. Evidence for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately -1.508 and an adjusted p-value of 0.04474. Which disease is associated with this gene? | glioma | Medium | convergence | {"qa_id":"medium_convergence_07044","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Cardiovirus A both downregulate a specific gene. Evidence for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change... | |
medium_convergence_07045 | Cyclosporine and Cimetidine both interact with a specific drug. Clinical evidence regarding this drug notes that pharmacokinetic parameters for cyclosporine A changed (Cmax -64%, Cmin +14%, AUC -47%; n = 2) before and after antiretroviral therapy (ART), although the changes were not statistically significant. What dise... | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_07045","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyclosporine and Cimetidine both interact with a specific drug. Clinical evidence regarding this drug notes that pharmacokinetic parameters for cyclosporine ... | |
medium_convergence_07046 | LAMTOR3 and ATG13 both interact with a specific protein. Evidence regarding this protein states: 'This phosphorylation inhibited the kinase activity of this protein, preventing it from binding to the downstream effector ATG13, and reduced autophagy in microglia.' Which protein is encoded by the gene corresponding to th... | Serine/threonine-protein kinase ULK1 | Medium | convergence | {"qa_id":"medium_convergence_07046","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR3 and ATG13 both interact with a specific protein. Evidence regarding this protein states: 'This phosphorylation inhibited the kinase activity of this ... | |
medium_convergence_07047 | DCUN1D3 and CUL1 both interact with a specific F-box protein that functions as part of the SCF complex alongside Skp1 and Cullin1. This protein specifically interacts with phosphorylated IkappaB and beta-catenin, targeting them for proteasome-dependent degradation in vivo. Which disease is associated with this protein? | neurodevelopmental, jaw, eye, and digital syndrome | Medium | convergence | {"qa_id":"medium_convergence_07047","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCUN1D3 and CUL1 both interact with a specific F-box protein that functions as part of the SCF complex alongside Skp1 and Cullin1. This protein specifically ... | |
medium_convergence_07048 | MIS18A and KNL1 both interact with a shared protein partner. Evidence regarding this partner states: 'We show that the N-terminal region of this protein spanning amino acid residues 20-130 directly interacts with Mis18α/β to form the Mis18 complex.' Which protein is encoded by the gene corresponding to this shared part... | Mis18-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_07048","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIS18A and KNL1 both interact with a shared protein partner. Evidence regarding this partner states: 'We show that the N-terminal region of this protein span... | |
medium_convergence_07049 | Human alphaherpesvirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.005 and an adjusted p-value of 0.002812. Which protein does this gene product bind to? | MDM2 | Medium | convergence | {"qa_id":"medium_convergence_07049","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) ... | |
medium_convergence_07050 | Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of -4.768 and an adjusted p-value of 0.04382. Which protein is encoded by this gene? | DNA dC->dU-editing enzyme APOBEC-3B | Medium | convergence | {"qa_id":"medium_convergence_07050","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475... | |
medium_convergence_07051 | PARP1 and H2AFZ share multiple interacting partners. One such shared partner is confirmed to interact with H2AFZ via GST pull-down, co-immunoprecipitation, and co-localization assays. Which protein is encoded by the gene corresponding to this specific shared partner? | Zinc finger protein 24 | Medium | convergence | {"qa_id":"medium_convergence_07051","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and H2AFZ share multiple interacting partners. One such shared partner is confirmed to interact with H2AFZ via GST pull-down, co-immunoprecipitation, a... | |
medium_convergence_07053 | CSNK1D and HSP90AB1 share a common interacting partner. Evidence from an Affinity Capture-MS study using Significance Analysis of INTeractome (SAINT) confirms a true interaction between this shared partner and heat shock protein 90 (Hsp90). Which disease is associated with this shared interacting partner? | ductal breast carcinoma in situ | Medium | convergence | {"qa_id":"medium_convergence_07053","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1D and HSP90AB1 share a common interacting partner. Evidence from an Affinity Capture-MS study using Significance Analysis of INTeractome (SAINT) confirm... | |
medium_convergence_07054 | Vaccinia virus and Human betaherpesvirus 5 both downregulate the expression of a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), the downregulation of this gene was associated with a log2 fold change of approximately -2.697 and an adjusted p-value of 0.01205. Which protein is encoded by ... | Juxtaposed with another zinc finger protein 1 | Medium | convergence | {"qa_id":"medium_convergence_07054","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate the expression of a specific gene. In a study using a cervical adenocarcinoma cell line (GSE1123... | |
medium_convergence_07055 | EIF3K and EIF3H share multiple binding partners. One shared partner is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein, encoded by the gene corresponding to this shared partner, is the target of the 'encodes' relationship? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_07055","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3K and EIF3H share multiple binding partners. One shared partner is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 ... | |
medium_convergence_07056 | CHRM3 and GNB1 both interact with multiple shared protein partners. One such shared partner is implicated in evidence stating: 'Co-immunoprecipitation assays using Cos-7 cells transiently expressing 48 different combinations of Gbeta(1-4) and Ggamma(1-5, 7-13) subunits showed that Gbeta(1) and Gbeta(4) could form dimer... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | Medium | convergence | {"qa_id":"medium_convergence_07056","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHRM3 and GNB1 both interact with multiple shared protein partners. One such shared partner is implicated in evidence stating: 'Co-immunoprecipitation assays... | |
medium_convergence_07057 | Both West Nile virus and Zaire ebolavirus are known to upregulate a specific shared gene. Experimental data for this gene in monocyte-derived dendritic cells (from study GSE136342) reports a log2 fold change of approximately 1.415 and an adjusted p-value of 0.04609. Which disease is associated with this specific gene? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_07057","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Zaire ebolavirus are known to upregulate a specific shared gene. Experimental data for this gene in monocyte-derived dendritic cells... | |
medium_convergence_07059 | UBLCP1 and PRKN share common interaction partners. One such shared partner is characterized by evidence indicating it binds to the proteasome subunit Rpn1 and dephosphorylates the proteasome. Which disease is associated with this specific shared partner? | lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_07059","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBLCP1 and PRKN share common interaction partners. One such shared partner is characterized by evidence indicating it binds to the proteasome subunit Rpn1 an... | |
medium_convergence_07060 | STUB1 and PARP1 share multiple interacting partners. One such partner is described in the following context: 'Here, using in vitro protein-protein interaction assays, we show that Parp2 interacts significantly with both the transition protein TP2 and the transition chaperone [ENTITY], whereas Parp1 binds weakly to [ENT... | Heat shock-related 70 kDa protein 2 | Medium | convergence | {"qa_id":"medium_convergence_07060","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and PARP1 share multiple interacting partners. One such partner is described in the following context: 'Here, using in vitro protein-protein interactio... | |
medium_convergence_07061 | ANKRD9 and ASB2 both interact with a shared protein partner. Evidence indicates that this partner associates with ELOC and presumably RNF7 subunits, forming a cullin-RING superfamily E3 ligase complex, and is distinct from CUL2. Which protein is encoded by this shared partner? | Cullin-5 | Medium | convergence | {"qa_id":"medium_convergence_07061","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANKRD9 and ASB2 both interact with a shared protein partner. Evidence indicates that this partner associates with ELOC and presumably RNF7 subunits, forming ... | |
medium_convergence_07062 | GNAI3 and GNAO1 both interact with a shared protein partner. Experimental evidence indicates that immunoprecipitation of the shared partner polypeptide in transfected cells leads to the co-precipitation of G(i) alpha 1 and G(i) alpha 3 polypeptides. Which cellular component is this shared partner located in? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_07062","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI3 and GNAO1 both interact with a shared protein partner. Experimental evidence indicates that immunoprecipitation of the shared partner polypeptide in tr... | |
medium_convergence_07063 | Both lung vasculature and urinary bladder vasculature are subtypes of a specific anatomical category. Evidence indicates that this category includes structures composed of tubules that carry blood or lymph in the lungs. Which anatomical structure is this category a part of? | organ | Medium | convergence | {"qa_id":"medium_convergence_07063","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both lung vasculature and urinary bladder vasculature are subtypes of a specific anatomical category. Evidence indicates that this category includes structur... | |
medium_convergence_07064 | GARS1 and HSPA1A both interact with a shared protein. Evidence regarding this shared protein states: 'Interestingly, the N-terminal extension of human glycyl-tRNA synthetase containing a single motif homologous to those in the bifunctional tRNA synthetase also interacted with the C-terminal motif of the isoleucyl-tRNA ... | Isoleucine--tRNA ligase, cytoplasmic | Medium | convergence | {"qa_id":"medium_convergence_07064","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GARS1 and HSPA1A both interact with a shared protein. Evidence regarding this shared protein states: 'Interestingly, the N-terminal extension of human glycyl... | |
medium_convergence_07065 | Both the androgen receptor (AR) and NONO share interaction partners. One such shared partner is a subunit of the SWI/SNF chromatin remodeling complex, which has been shown to display hormone-dependent interactions with AR through its FxxFF motif. Which protein encodes this shared interaction partner? | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 | Medium | convergence | {"qa_id":"medium_convergence_07065","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the androgen receptor (AR) and NONO share interaction partners. One such shared partner is a subunit of the SWI/SNF chromatin remodeling complex, which ... | |
medium_convergence_07066 | SMAD3 and MYC share multiple interacting partners. One such partner is identified in the following evidence: 'Here, we report that [protein X] is a novel SMAD3-interacting protein.' Which protein is encoded by this specific interacting partner? | Tribbles homolog 3 | Medium | convergence | {"qa_id":"medium_convergence_07066","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD3 and MYC share multiple interacting partners. One such partner is identified in the following evidence: 'Here, we report that [protein X] is a novel SMA... | |
medium_convergence_07067 | CRK and MLLT4 share multiple binding partners. One shared partner is implicated in evidence stating: 'We further demonstrate that both Ras and Rap1 interact with full-length AF-6 in vivo in mammalian cells and that a fraction of Rap1 colocalizes with AF-6 at the membrane.' Which protein is encoded by the gene correspon... | Ras-related protein Rap-1A | Medium | convergence | {"qa_id":"medium_convergence_07067","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and MLLT4 share multiple binding partners. One shared partner is implicated in evidence stating: 'We further demonstrate that both Ras and Rap1 interact ... | |
medium_convergence_07068 | CENPS and CENPL each interact with more than one shared partner. Evidence concerning one shared entity reports that Fluorescent two-hybrid analysis identified this shared partner as a uniquely strong CENP-S binding protein, and this association was confirmed by FRET, revealing a centromere-bound complex containing CENP... | short stature and microcephaly with genital anomalies | Medium | convergence | {"qa_id":"medium_convergence_07068","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPS and CENPL each interact with more than one shared partner. Evidence concerning one shared entity reports that Fluorescent two-hybrid analysis identifie... | |
medium_convergence_07069 | STX6 and STX1A both interact with a shared protein. Evidence indicates that in vitro binding studies established that SNAP-23 binds to syntaxin 6. Which cell type is enriched for this shared protein? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_07069","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STX6 and STX1A both interact with a shared protein. Evidence indicates that in vitro binding studies established that SNAP-23 binds to syntaxin 6. Which cell... | |
medium_convergence_07071 | The androgen receptor (AR) and the histone variant H4C1 (encoded by HIST1H4A) both interact with a common protein partner. Experimental evidence indicates that the AR antagonist RU486 (mifepristone) strongly stimulates the binding between AR and this shared partner, which functions as a nuclear receptor corepressor. Wh... | Nuclear receptor corepressor 1 | Medium | convergence | {"qa_id":"medium_convergence_07071","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The androgen receptor (AR) and the histone variant H4C1 (encoded by HIST1H4A) both interact with a common protein partner. Experimental evidence indicates th... | |
medium_convergence_07072 | Both Influenza A virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene, derived from bronchial epithelial cells, reports a log2 fold change of approximately 1.064 and an adjusted p-value of 0.01375. Which disease is associated with this gene as a biomarker? | glioma | Medium | convergence | {"qa_id":"medium_convergence_07072","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene, derived from bronchial epithelial c... | |
medium_convergence_07073 | PCNA and ISG15 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Indeed, we show that both polymerases interact noncovalently with free polyUb chains, as well as mono-ubiquitinated proliferating cell nuclear antigen (Ub-PCNA).' Which protein is connected to that entity thr... | DNA polymerase iota | Medium | convergence | {"qa_id":"medium_convergence_07073","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCNA and ISG15 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Indeed, we show that both polymerases interac... | |
medium_convergence_07074 | Both the androgen receptor (AR) and the nuclear factor I/C (NFIC) protein interact with a specific shared partner protein. Evidence indicates that the SWI/SNF chromatin remodeling complex is critical for the transcriptional activity of this shared partner, and that a subunit of the SWI/SNF complex facilitates direct in... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 | Medium | convergence | {"qa_id":"medium_convergence_07074","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the androgen receptor (AR) and the nuclear factor I/C (NFIC) protein interact with a specific shared partner protein. Evidence indicates that the SWI/SN... | |
medium_convergence_07075 | VPS36 and CHMP1A share common binding partners. One such shared partner is described by evidence stating: 'Immunocytochemistry and biochemical fractionation localize CHMP1 to early endosomes and CHMP1 physically interacts with a highly conserved protein directly linked to multivesicular body sorting in yeast.' Which pr... | Vacuolar protein sorting-associated protein 4A | Medium | convergence | {"qa_id":"medium_convergence_07075","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS36 and CHMP1A share common binding partners. One such shared partner is described by evidence stating: 'Immunocytochemistry and biochemical fractionation ... | |
medium_convergence_07077 | AKAP9 and CDK5RAP2 share a common interacting partner. Evidence indicates that SMYLE associates with this shared partner through an evolutionarily conserved N-terminal domain, and this partner is anchored at the centrosome via CDK5RAP2. Which protein is encoded by this shared interacting partner? | Myomegalin | Medium | convergence | {"qa_id":"medium_convergence_07077","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP9 and CDK5RAP2 share a common interacting partner. Evidence indicates that SMYLE associates with this shared partner through an evolutionarily conserved ... | |
medium_convergence_07078 | HDAC1 and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports that co-immunoprecipitations indicated that this entity bridges an interaction between E2Fs 3 and 4 and HDAC1. Which disease is connected to that entity through genomic alterations? | kidney Wilms tumor | Medium | convergence | {"qa_id":"medium_convergence_07078","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports that co-immunoprecipitations indicated that thi... | |
medium_convergence_07079 | CLTC and DNAJC6 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The interaction with clathrin is direct and not mediated by epsin-bound AP-2.' Which protein is encoded by the gene corresponding to that specific shared partner? | Epsin-1 | Medium | convergence | {"qa_id":"medium_convergence_07079","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLTC and DNAJC6 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The interaction with clath... | |
medium_convergence_07080 | PARP1 and HDAC1 share multiple interacting partners. One such shared partner is known to associate with transcriptional repressors including KAP1, histone deacetylases HDAC1/2, and the histone methyltransferase G9a/GLP, and it modulates the interaction of HDAC1 and KAP1 with heterochromatin. Which cell type is enriched... | basophil | Medium | convergence | {"qa_id":"medium_convergence_07080","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and HDAC1 share multiple interacting partners. One such shared partner is known to associate with transcriptional repressors including KAP1, histone de... | |
medium_convergence_07081 | COPB1 and COPG1 both interact with a shared protein. Evidence indicates that this shared protein was identified for the first time as an interaction partner of hSAC1, specifically as a member of the coatomer I (COPI) complex. Which protein is encoded by this shared entity? | Phosphatidylinositol-3-phosphatase SAC1 | Medium | convergence | {"qa_id":"medium_convergence_07081","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and COPG1 both interact with a shared protein. Evidence indicates that this shared protein was identified for the first time as an interaction partner ... | |
medium_convergence_07082 | COG2 and COG4 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Our results suggest that COG4 serves as a core component of the complex by interacting directly with COG1, COG2, COG5, and this shared partner.' Which protein is encoded by the gene corresponding ... | Conserved oligomeric Golgi complex subunit 7 | Medium | convergence | {"qa_id":"medium_convergence_07082","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COG2 and COG4 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Our results suggest that COG4 ser... | |
medium_convergence_07083 | DBF4 and ORC3 both interact with a common protein partner. Experimental evidence regarding this partner describes the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4, HsOrc3-HsOrc4, HsOrc2-HsOrc6, and HsOrc3-HsOrc6. Which protein is encoded by the gene corresponding to this shared partner? | Origin recognition complex subunit 6 | Medium | convergence | {"qa_id":"medium_convergence_07083","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DBF4 and ORC3 both interact with a common protein partner. Experimental evidence regarding this partner describes the following binary interactions: HsOrc2-H... | |
medium_convergence_07084 | Human polyomavirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of 1.614 and an adjusted p-value of 0.03798. Which protein is encoded by this gene? | Autophagy-related protein 13 | Medium | convergence | {"qa_id":"medium_convergence_07084","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a lo... | |
medium_convergence_07085 | GNAI2 and GNAQ both interact with a shared protein partner. Experimental evidence indicates that this partner, along with RGS16, binds to the Galphai and Galphao subunits of heterotrimeric G-proteins in vitro, but does not bind to Galphas. What is the name of the protein encoded by this shared partner? | Regulator of G-protein signaling 5 | Medium | convergence | {"qa_id":"medium_convergence_07085","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI2 and GNAQ both interact with a shared protein partner. Experimental evidence indicates that this partner, along with RGS16, binds to the Galphai and Gal... | |
medium_convergence_07086 | The pedal digit metatarsal endochondral element and the tarsus endochondral element share a common anatomical category. Evidence regarding one of these shared entities describes it as a pedal digit metatarsal bone or its cartilage or pre-cartilage precursor. Which anatomical structure is this shared entity a part of? | autopodial skeleton | Medium | convergence | {"qa_id":"medium_convergence_07086","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The pedal digit metatarsal endochondral element and the tarsus endochondral element share a common anatomical category. Evidence regarding one of these share... | |
medium_convergence_07088 | CD55 and ARCN1 both interact with a shared protein partner. Experimental evidence for this partner includes immunoprecipitation and two-hybrid analysis from a complete COP screen, which demonstrated physical interactions between alpha- and epsilon-COPs, as well as between beta- and delta-COPs. Which protein is encoded ... | Coatomer subunit beta | Medium | convergence | {"qa_id":"medium_convergence_07088","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CD55 and ARCN1 both interact with a shared protein partner. Experimental evidence for this partner includes immunoprecipitation and two-hybrid analysis from ... | |
medium_convergence_07089 | GABRA2 and GABRB1 are both involved in multiple shared biological processes. One of these shared processes is supported by evidence stating: 'we determined the impact of GABRB mutations on GABAA receptor function and biogenesis.' Which broader biological process is this specific shared process a subclass of? | cell-cell signaling | Medium | convergence | {"qa_id":"medium_convergence_07089","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GABRA2 and GABRB1 are both involved in multiple shared biological processes. One of these shared processes is supported by evidence stating: 'we determined t... | |
medium_convergence_07090 | HSPA9 and GRPEL1 both interact with a shared mitochondrial protein. Evidence indicates that this shared entity is a peripheral inner-membrane protein that tethers the complex to the import channel. Which protein product is encoded by the gene corresponding to this shared entity? | Mitochondrial import inner membrane translocase subunit TIM44 | Medium | convergence | {"qa_id":"medium_convergence_07090","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA9 and GRPEL1 both interact with a shared mitochondrial protein. Evidence indicates that this shared entity is a peripheral inner-membrane protein that te... | |
medium_convergence_07091 | CHEK1 and GRB10 both interact with a specific protein. Experimental evidence for this interaction describes a yeast two-hybrid screen where the cytoplasmic tail of this protein was fused to LexA as bait against a mouse embryo cDNA library, revealing that the Grb10 SH2 domain interacted with the protein's receptor tyros... | Mast/stem cell growth factor receptor Kit | Medium | convergence | {"qa_id":"medium_convergence_07091","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and GRB10 both interact with a specific protein. Experimental evidence for this interaction describes a yeast two-hybrid screen where the cytoplasmic t... | |
medium_convergence_07092 | TRIM28 and EGFR share a common interacting partner. Evidence regarding this shared entity states: 'The structure of the protein tyrosine phosphatase bound with DADEpYL-NH(2) offers a structural explanation for its preference for acidic residues [Jia, Z., Barford, D., Flint, A. J., and Tonks, N. K. (1995) Science 268, 1... | childhood leukemia | Medium | convergence | {"qa_id":"medium_convergence_07092","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and EGFR share a common interacting partner. Evidence regarding this shared entity states: 'The structure of the protein tyrosine phosphatase bound wi... | |
medium_convergence_07093 | KCNA5 and KCNQ1 are both involved in multiple shared biological processes. One of these shared processes is linked to evidence stating: 'Thus, the S140G mutation is likely to initiate and maintain AF by reducing action potential duration and effective refractory period in atrial myocytes.' Which biological process is t... | regulation of cardiac muscle cell membrane repolarization | Medium | convergence | {"qa_id":"medium_convergence_07093","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNA5 and KCNQ1 are both involved in multiple shared biological processes. One of these shared processes is linked to evidence stating: 'Thus, the S140G muta... | |
medium_convergence_07094 | PSMA1 and PSMA5 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein is encoded by this shared partner? | Proteasome subunit alpha type-7 | Medium | convergence | {"qa_id":"medium_convergence_07094","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA1 and PSMA5 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S prote... | |
medium_convergence_07095 | YWHAE and HIST1H4A share common interaction partners. One such shared partner is described in literature stating: 'We now identify 14-3-3 proteins as in vivo interaction partners of this protein, both in yeast and mammalian cells.' Which gene is connected to this specific shared entity through an 'interacts with' relat... | DCAF1 | Medium | convergence | {"qa_id":"medium_convergence_07095","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAE and HIST1H4A share common interaction partners. One such shared partner is described in literature stating: 'We now identify 14-3-3 proteins as in vivo... | |
medium_convergence_07096 | EGFR and MET share a common interacting partner. Evidence indicates that for this shared partner, the long isoform (but not the short isoform) interacts with the complex formed by the partner, HSP70, and HSP90 via the DnaJ domain. This interaction counteracts the partner's regulatory function on HSP90 by inducing the p... | ovarian neoplasm | Medium | convergence | {"qa_id":"medium_convergence_07096","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and MET share a common interacting partner. Evidence indicates that for this shared partner, the long isoform (but not the short isoform) interacts with... | |
medium_convergence_07097 | RPA1 and TP53 share a common interacting partner. Evidence indicates that this partner phosphorylates human p53 at Thr18 and disrupts the p53-Mdm2 interaction in vitro, although a significant decrease in p53 ubiquitination by Mdm2 in vivo was not detected. Which protein is encoded by the gene corresponding to this inte... | Serine/threonine-protein kinase VRK1 | Medium | convergence | {"qa_id":"medium_convergence_07097","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPA1 and TP53 share a common interacting partner. Evidence indicates that this partner phosphorylates human p53 at Thr18 and disrupts the p53-Mdm2 interactio... | |
medium_convergence_07098 | GTF2H1 and RBX1 both interact with a common protein. Experimental evidence indicates that at physiological ionic strength, the TFIIH complex associates significantly with this protein (in a complex with HR23B) and with XPG, but not with other repair factors. Which protein product is encoded by this common interacting p... | DNA repair protein complementing XP-C cells | Medium | convergence | {"qa_id":"medium_convergence_07098","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2H1 and RBX1 both interact with a common protein. Experimental evidence indicates that at physiological ionic strength, the TFIIH complex associates signi... | |
medium_convergence_07099 | FANCA and FANCF both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Here, we demonstrate that the WD40 repeats of this protein are required for interaction with other subunits of the FA complex.' Which protein product is encoded by this shared interaction partner? | E3 ubiquitin-protein ligase FANCL | Medium | convergence | {"qa_id":"medium_convergence_07099","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and FANCF both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Here, we demonstrate that the WD40 repeats... | |
medium_convergence_07101 | HDAC1 and RNF4 each interact with more than one shared gene. Evidence concerning one shared entity reports that coimmunoprecipitation experiments indicate that the entity and HDAC2 are associated with Topo II in vivo under normal physiological conditions. Which disease is connected to that entity through an association... | B-cell immunodeficiency, distal limb anomalies, and urogenital malformations | Medium | convergence | {"qa_id":"medium_convergence_07101","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and RNF4 each interact with more than one shared gene. Evidence concerning one shared entity reports that coimmunoprecipitation experiments indicate th... | |
medium_convergence_07102 | CAND1 and AURKB both interact with a shared protein. Evidence regarding this shared protein states: 'Instead, the protein(Δ403-459) auto-ubiquitylates and loses interaction with two important Cullin regulators: the COP9-signalosome and CAND1.' Which protein is encoded by this shared entity? | Cullin-3 | Medium | convergence | {"qa_id":"medium_convergence_07102","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and AURKB both interact with a shared protein. Evidence regarding this shared protein states: 'Instead, the protein(Δ403-459) auto-ubiquitylates and lo... | |
medium_convergence_07103 | LEF1 and BCL9 both interact with a shared protein partner. Evidence regarding this partner states: 'Here, we identify four conserved residues at the putative PHD domain surface of Drosophila and mouse Pygopus that are required for their binding to Legless in vitro and in vivo.' Which protein is encoded by the gene corr... | Pygopus homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_07103","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LEF1 and BCL9 both interact with a shared protein partner. Evidence regarding this partner states: 'Here, we identify four conserved residues at the putative... | |
medium_convergence_07105 | CSNK2A2 and MSH3 share multiple interacting partners. One such shared partner is a protein component of the human 9-1-1 complex, which is specifically phosphorylated by casein kinase 2 (CK2) at serines 341 and 387 in its C-terminal tail. Which protein is encoded by the gene corresponding to this shared interacting part... | Cell cycle checkpoint control protein RAD9A | Medium | convergence | {"qa_id":"medium_convergence_07105","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A2 and MSH3 share multiple interacting partners. One such shared partner is a protein component of the human 9-1-1 complex, which is specifically phosph... | |
medium_convergence_07106 | CDK9 and AR share multiple interacting partners. One such partner is an E3 ubiquitin ligase that associates with the CDK9 subunit of positive transcription elongation factor b to mediate its polyubiquitination in human cells. Which protein is encoded by this E3 ubiquitin ligase gene? | E3 ubiquitin-protein ligase UBR5 | Medium | convergence | {"qa_id":"medium_convergence_07106","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK9 and AR share multiple interacting partners. One such partner is an E3 ubiquitin ligase that associates with the CDK9 subunit of positive transcription e... |
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