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medium_convergence_07107 | GSK3B and KRAS both interact with a specific shared protein. Experimental evidence indicates that GSK-3 beta binds to and phosphorylates this protein in both in vitro and in vivo settings. Which protein is encoded by the gene corresponding to this shared interaction partner? | Neurogenic locus notch homolog protein 2 | Medium | convergence | {"qa_id":"medium_convergence_07107","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GSK3B and KRAS both interact with a specific shared protein. Experimental evidence indicates that GSK-3 beta binds to and phosphorylates this protein in both... | |
medium_convergence_07108 | CSNK1D and APC both interact with a shared protein. Experimental evidence indicates that this shared protein was co-precipitated with either GSK3beta or beta-catenin in both cell lines using immunoprecipitation. Which disease is associated with this shared protein? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_07108","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1D and APC both interact with a shared protein. Experimental evidence indicates that this shared protein was co-precipitated with either GSK3beta or beta... | |
medium_convergence_07109 | Gatifloxacin and Norfloxacin both interact with a specific shared entity. Evidence indicates that when Selacid GG is added to feeds, the number of E. coli isolates resistant to this entity is significantly reduced, and the susceptibility of E. coli to this entity is increased. Which drug interacts with this entity? | Aluminum hydroxide | Medium | convergence | {"qa_id":"medium_convergence_07109","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Gatifloxacin and Norfloxacin both interact with a specific shared entity. Evidence indicates that when Selacid GG is added to feeds, the number of E. coli is... | |
medium_convergence_07110 | YAP1 and EP300 share multiple interaction partners. One such shared partner is described in evidence stating: 'We demonstrate that both P300 and PCAF act as cofactors for this protein, forming a P300/PCAF/this protein complex on the miR200c/141 promoter.' Which protein is encoded by this shared entity? | Zinc finger E-box-binding homeobox 1 | Medium | convergence | {"qa_id":"medium_convergence_07110","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and EP300 share multiple interaction partners. One such shared partner is described in evidence stating: 'We demonstrate that both P300 and PCAF act as ... | |
medium_convergence_07112 | Both IL1B and IL1R1 interact with a shared downstream signaling molecule. Experimental evidence indicates that when human embryonic kidney cells (HEK293) over-expressing IL-1RI or HeLa cells are exposed to IL-1, this molecule rapidly associates with the IL-1RI complex and undergoes phosphorylation. Which cell type is t... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_07112","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IL1B and IL1R1 interact with a shared downstream signaling molecule. Experimental evidence indicates that when human embryonic kidney cells (HEK293) ove... | |
medium_convergence_07113 | SEC61B and CTNNB1 share common interaction partners. One such partner is reported to interact with CTNNB1 and stabilize it by suppressing its degradation. Which protein is encoded by this stabilizing partner? | Ubiquitin carboxyl-terminal hydrolase 33 | Medium | convergence | {"qa_id":"medium_convergence_07113","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SEC61B and CTNNB1 share common interaction partners. One such partner is reported to interact with CTNNB1 and stabilize it by suppressing its degradation. Wh... | |
medium_convergence_07116 | GNB1 and PTH both interact with a specific receptor protein. Experimental evidence indicates that an analog photocrosslinks specifically to the recombinant human PTH/PTHrP receptor stably transfected into human embryonic kidney cells (HEK-293/C-21 cells), generating a diffuse approximately 87-kDa band on SDS/PAGE autor... | Parathyroid hormone/parathyroid hormone-related peptide receptor | Medium | convergence | {"qa_id":"medium_convergence_07116","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNB1 and PTH both interact with a specific receptor protein. Experimental evidence indicates that an analog photocrosslinks specifically to the recombinant h... | |
medium_convergence_07117 | JAK1 and LYN both interact with a specific shared protein. Evidence indicates that the kinase inhibitory region of this protein targets the substrate binding groove of JAK with high specificity, thereby blocking subsequent phosphorylation. In which cellular component is this protein located? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_07117","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JAK1 and LYN both interact with a specific shared protein. Evidence indicates that the kinase inhibitory region of this protein targets the substrate binding... | |
medium_convergence_07119 | KAT5 and CBX3 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here, we show that chromobox homolog 8, a Polycomb Group protein that interacts with MLL-AF9 and TIP60, is required for MLL-AF9-induced transcriptional activation and leukemogenesis.' Which protein is conn... | Chromobox protein homolog 8 | Medium | convergence | {"qa_id":"medium_convergence_07119","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and CBX3 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here, we show that chromobox homolog 8, a ... | |
medium_convergence_07121 | MED6 and TAF11 both interact with a specific nuclear receptor. Experimental evidence indicates that the interaction between hTAF(II)28 and this receptor's ligand-binding domain (LBD) is ligand-reversible, whereas no such interactions were observed with retinoid X receptors (RXRs) or other receptors. Which protein is en... | Thyroid hormone receptor alpha | Medium | convergence | {"qa_id":"medium_convergence_07121","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED6 and TAF11 both interact with a specific nuclear receptor. Experimental evidence indicates that the interaction between hTAF(II)28 and this receptor's li... | |
medium_convergence_07123 | DCTN1 and DYNC1I1 both interact with a specific shared protein. Evidence indicates that dynein and dynactin depend on each other for this protein-mediated targeting to cargo, and that the N-terminus of this protein strongly promotes stable interaction between dynein and dynactin both in vitro and in vivo. Which protein... | Protein bicaudal D homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_07123","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCTN1 and DYNC1I1 both interact with a specific shared protein. Evidence indicates that dynein and dynactin depend on each other for this protein-mediated ta... | |
medium_convergence_07124 | CHEK1 and TP53 share multiple interacting partners. One such partner is confirmed to interact with Chk1 during the cell cycle based on co-immunoprecipitation experiments using exogenous protein transfected into human cells. Which cell type is this specific interacting partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_07124","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and TP53 share multiple interacting partners. One such partner is confirmed to interact with Chk1 during the cell cycle based on co-immunoprecipitation... | |
medium_convergence_07125 | RHOB and MLLT4 both interact with a specific shared protein. Evidence indicates that this shared protein was identified as a ligand for the PDZ domain of the cell junction and Ras-interacting protein AF-6. Which protein is encoded by this shared entity? | Breakpoint cluster region protein | Medium | convergence | {"qa_id":"medium_convergence_07125","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOB and MLLT4 both interact with a specific shared protein. Evidence indicates that this shared protein was identified as a ligand for the PDZ domain of the... | |
medium_convergence_07126 | CAPN1 and CAPN2 both interact with a shared protein partner. Evidence regarding this partner states: 'The best characterized calpains are the ubiquitously expressed mu- and m-calpains, consisting of a common 30 kDa small S-subunit (domains V and VI) and slightly differing 80 kDa large L-subunits (domains I to IV).' Whi... | Calpain small subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_07126","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAPN1 and CAPN2 both interact with a shared protein partner. Evidence regarding this partner states: 'The best characterized calpains are the ubiquitously ex... | |
medium_convergence_07127 | BARD1 and UBC both interact with a specific ubiquitin-conjugating enzyme. Evidence regarding this shared partner states: 'We present the structure of the BRCA1/BARD1 RING heterodimer with the E2 enzyme [shared partner] bound to its cellular target, the nucleosome, along with biochemical data that explain how the comple... | Ubiquitin-conjugating enzyme E2 D3 | Medium | convergence | {"qa_id":"medium_convergence_07127","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BARD1 and UBC both interact with a specific ubiquitin-conjugating enzyme. Evidence regarding this shared partner states: 'We present the structure of the BRC... | |
medium_convergence_07128 | EWSR1 and MYC share multiple interacting partners. One such partner is identified in a study reporting that a specific protein interacts with EWS in both two-hybrid assays and glutathione S-transferase pull-down experiments. Which protein is encoded by this shared interacting partner? | Splicing factor 1 | Medium | convergence | {"qa_id":"medium_convergence_07128","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EWSR1 and MYC share multiple interacting partners. One such partner is identified in a study reporting that a specific protein interacts with EWS in both two... | |
medium_convergence_07129 | PSMA2 and PSMA4 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein is encoded by this shared partner? | Proteasome subunit alpha type-6 | Medium | convergence | {"qa_id":"medium_convergence_07129","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA2 and PSMA4 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S prote... | |
medium_convergence_07130 | COPS6 and JUN each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here, we show that CSN6 associates with a kinase and reduces its expression level by facilitating the ubiquitin-mediated degradation of that kinase.' Which protein is connected to that entity through the '... | Mitogen-activated protein kinase kinase kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_07130","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS6 and JUN each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here, we show that CSN6 associates with a ... | |
medium_convergence_07132 | Cardiovirus A and Zika virus both upregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE122967) indicates that this gene has a log2 fold change of approximately 1.826 and an adjusted p-value of 0.004997. Which protein does this gene product bind to? | TP53 | Medium | convergence | {"qa_id":"medium_convergence_07132","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cardiovirus A and Zika virus both upregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE122967) indicates that thi... | |
medium_convergence_07133 | TSG101 and CHMP4C each interact with more than one shared partner. Evidence concerning one shared entity reports: 'Specifically, a subunit of the ESCRT-II complex bound ubiquitin via its N-terminal GRAM-like ubiquitin-binding domain, both this subunit and another ESCRT-II subunit bound the C-terminal domain of TSG101/E... | lipoma | Medium | convergence | {"qa_id":"medium_convergence_07133","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TSG101 and CHMP4C each interact with more than one shared partner. Evidence concerning one shared entity reports: 'Specifically, a subunit of the ESCRT-II co... | |
medium_convergence_07134 | BRCC3 and MDC1 share multiple binding partners. One such shared partner facilitates the accumulation of checkpoint mediator proteins BRCA1 and 53BP1 at damaged chromatin, specifically through phospho-dependent binding via its FHA domain to MDC1. Which disease is associated with this shared partner as a biomarker? | Fanconi anemia complementation group A | Medium | convergence | {"qa_id":"medium_convergence_07134","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCC3 and MDC1 share multiple binding partners. One such shared partner facilitates the accumulation of checkpoint mediator proteins BRCA1 and 53BP1 at damag... | |
medium_convergence_07135 | CDC37 and ARHGEF12 both interact with a specific shared protein. Experimental evidence indicates that LARG forms a complex with the IGF-1 receptor in vivo, and the PDZ domain of LARG interacts directly with the COOH-terminal domain of the IGF-1 receptor in vitro. Based on this evidence identifying the shared entity, wh... | Insulin-like growth factor 1 receptor | Medium | convergence | {"qa_id":"medium_convergence_07135","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and ARHGEF12 both interact with a specific shared protein. Experimental evidence indicates that LARG forms a complex with the IGF-1 receptor in vivo, a... | |
medium_convergence_07137 | CHAF1A and CBX1 each interact with more than one shared gene product. Evidence concerning one of these shared entities states: 'Members of the heterochromatin protein 1 (HP1) family are silencing nonhistone proteins. Here, we show that in P19 embryonal carcinoma (EC) nuclei, HP1 alpha, beta, and gamma form homo- and he... | Chromobox protein homolog 3 | Medium | convergence | {"qa_id":"medium_convergence_07137","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHAF1A and CBX1 each interact with more than one shared gene product. Evidence concerning one of these shared entities states: 'Members of the heterochromati... | |
medium_convergence_07138 | MDM2 and NPM1 share multiple interacting partners. One such shared partner is distinguished by the following evidence: the N-terminal region of either this entity or RPS27 binds to MDM2 on the central acidic domain of MDM2. Which cellular component is this shared partner located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_07138","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and NPM1 share multiple interacting partners. One such shared partner is distinguished by the following evidence: the N-terminal region of either this e... | |
medium_convergence_07139 | Human betaherpesvirus 5 and Human gammaherpesvirus 4 both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE130665) reports a log2 fold change of -1.216 and an adjusted p-value of 0.04117. Which molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_07139","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human gammaherpesvirus 4 both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (fr... | |
medium_convergence_07140 | BICD2 and RAN share multiple interacting partners. One such shared partner was purified from HeLa cell lysates and was found to induce the GTPase activity of RAN, but not Ras, by more than three orders of magnitude. Which protein is encoded by this shared interacting partner? | Ran GTPase-activating protein 1 | Medium | convergence | {"qa_id":"medium_convergence_07140","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BICD2 and RAN share multiple interacting partners. One such shared partner was purified from HeLa cell lysates and was found to induce the GTPase activity of... | |
medium_convergence_07141 | DAXX and DHX9 both interact with a specific shared protein. Evidence indicates that this shared protein, described as a modulator of apoptosis and a repressor of basal transcription, was identified in a two-hybrid screen as capable of interacting with a trimeric form of human heat shock factor 1. Which protein is encod... | Heat shock factor protein 1 | Medium | convergence | {"qa_id":"medium_convergence_07141","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and DHX9 both interact with a specific shared protein. Evidence indicates that this shared protein, described as a modulator of apoptosis and a represso... | |
medium_convergence_07142 | EHMT2 and EZH2 share multiple interacting partners. One such shared partner has been shown to bind G9a, a finding confirmed by glutathione S-transferase pulldown assays in vitro and coimmunoprecipitation in vivo. Which disease is associated with this specific shared partner through genomic alterations? | Familial X-linked hypophosphatemic vitamin D refractory rickets | Medium | convergence | {"qa_id":"medium_convergence_07142","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and EZH2 share multiple interacting partners. One such shared partner has been shown to bind G9a, a finding confirmed by glutathione S-transferase pull... | |
medium_convergence_07143 | CDC37 and DDX3X both interact with a shared protein. Evidence indicates that virus infection induces an association between DDX3 and IKKepsilon. Which protein is encoded by this shared entity? | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | Medium | convergence | {"qa_id":"medium_convergence_07143","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and DDX3X both interact with a shared protein. Evidence indicates that virus infection induces an association between DDX3 and IKKepsilon. Which protei... | |
medium_convergence_07144 | AMOT and EGFR share interaction partners. One such shared partner is described in a study stating: 'Here, we demonstrate that the cellular protein Angiomotin can bind both this protein and HIV-1 Gag.' Which protein is encoded by this shared interaction partner? | E3 ubiquitin-protein ligase NEDD4-like | Medium | convergence | {"qa_id":"medium_convergence_07144","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMOT and EGFR share interaction partners. One such shared partner is described in a study stating: 'Here, we demonstrate that the cellular protein Angiomotin... | |
medium_convergence_07145 | PARD6A and PARD3 both interact with a shared protein partner. One piece of evidence states: 'On the other hand, we also found that aPKC associates not only with ASIP/PAR-3, but also with a mammalian homologue of C. elegans PAR-6 (mPAR-6), and thereby mediates the formation of an aPKC-ASIP/PAR-3-PAR-6 ternary complex th... | ovarian cancer | Medium | convergence | {"qa_id":"medium_convergence_07145","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARD6A and PARD3 both interact with a shared protein partner. One piece of evidence states: 'On the other hand, we also found that aPKC associates not only w... | |
medium_convergence_07146 | Both FUS and AR interact with a shared protein partner. Experimental evidence indicates that this partner was identified as a binding partner of AR via co-immunoprecipitation in luteinized granulosa cells, with confirmation through co-localization and GST pull-down assays. Which protein is encoded by this shared partne... | Phosphoglycerate kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_07146","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both FUS and AR interact with a shared protein partner. Experimental evidence indicates that this partner was identified as a binding partner of AR via co-im... | |
medium_convergence_07147 | EGFR and LYN both interact with a shared protein. Evidence indicates that this shared protein forms a physical complex with EGFRvIII. Which protein is encoded by the gene corresponding to this shared entity? | Hepatocyte growth factor receptor | Medium | convergence | {"qa_id":"medium_convergence_07147","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and LYN both interact with a shared protein. Evidence indicates that this shared protein forms a physical complex with EGFRvIII. Which protein is encode... | |
medium_convergence_07148 | CTNNB1 and APC share multiple interacting partners. One such partner is distinguished by evidence that Siah-1 alone was able to polyubiquitinate beta-catenin. Which protein is connected to this specific interacting partner through the 'encodes' relationship? | E3 ubiquitin-protein ligase SIAH1 | Medium | convergence | {"qa_id":"medium_convergence_07148","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and APC share multiple interacting partners. One such partner is distinguished by evidence that Siah-1 alone was able to polyubiquitinate beta-catenin... | |
medium_convergence_07149 | EIF3A and EIF3C both interact with a shared protein partner. Experimental evidence indicates that eIF3-p44 interacts strongly and specifically with the eIF3-p170 subunit, and weakly with p116/p110, p66, p40, and itself. Which protein, encoded by the gene corresponding to this shared partner, is the subject of this inte... | Eukaryotic translation initiation factor 3 subunit D | Medium | convergence | {"qa_id":"medium_convergence_07149","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3A and EIF3C both interact with a shared protein partner. Experimental evidence indicates that eIF3-p44 interacts strongly and specifically with the eIF3-... | |
medium_convergence_07150 | Vaccinia virus and Human mastadenovirus C both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 2.97 and an adjusted p-value of 2.24e-05. In which cell type is this gene enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_07150","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human mastadenovirus C both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE1... | |
medium_convergence_07151 | CTNNB1 and SIRT1 share multiple interacting partners. One such shared partner is known to form a complex with β-Catenin in both the nucleus and the cytoplasm. Which protein is encoded by this shared partner? | Hypoxia-inducible factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_07151","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and SIRT1 share multiple interacting partners. One such shared partner is known to form a complex with β-Catenin in both the nucleus and the cytoplasm... | |
medium_convergence_07152 | MED16 and TAF11 both interact with a specific nuclear receptor. Experimental evidence indicates that the interaction between hTAF(II)28 and this receptor's ligand-binding domain (LBD) is ligand-reversible, whereas no such interactions were observed with retinoid X receptors (RXRs) or other receptors. Which protein is e... | Thyroid hormone receptor alpha | Medium | convergence | {"qa_id":"medium_convergence_07152","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED16 and TAF11 both interact with a specific nuclear receptor. Experimental evidence indicates that the interaction between hTAF(II)28 and this receptor's l... | |
medium_convergence_07153 | TRIM28 and CCT5 share multiple interacting partners. One such shared partner is part of a PP4C/R3β complex that interacts with KAP-1; silencing this complex results in the persistence of phospho-S824 and phospho-S473. Which disease is associated with this specific shared partner via a biomarker relationship? | endometrioid stromal sarcoma | Medium | convergence | {"qa_id":"medium_convergence_07153","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CCT5 share multiple interacting partners. One such shared partner is part of a PP4C/R3β complex that interacts with KAP-1; silencing this complex ... | |
medium_convergence_07154 | EP300 and FOS both interact with a shared protein partner. Experimental evidence indicates that immunoprecipitation and chromatin immunoprecipitation analyses demonstrate the in vivo interaction between this specific partner and p300. Which disease is causally linked to this protein partner? | congestive heart failure | Medium | convergence | {"qa_id":"medium_convergence_07154","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and FOS both interact with a shared protein partner. Experimental evidence indicates that immunoprecipitation and chromatin immunoprecipitation analyse... | |
medium_convergence_07155 | RAB32 and RAB38 are both localized to a specific cellular component. Experimental evidence indicates that silencing the BLOC-3 subunits Hps1 and Hps4 leads to the mislocalization of RAB32 and RAB38, accompanied by a reduction in pigmentation. Based on this evidence, which cellular component is the parent category (is_a... | pigment granule membrane | Medium | convergence | {"qa_id":"medium_convergence_07155","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAB32 and RAB38 are both localized to a specific cellular component. Experimental evidence indicates that silencing the BLOC-3 subunits Hps1 and Hps4 leads t... | |
medium_convergence_07156 | CTNNB1 and FANCA share a common interacting partner. Evidence indicates that this shared partner, along with IKKalpha, interacts with and phosphorylates beta-catenin in both in vitro and in vivo assays. Which protein is encoded by this shared interacting partner? | Inhibitor of nuclear factor kappa-B kinase subunit beta | Medium | convergence | {"qa_id":"medium_convergence_07156","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and FANCA share a common interacting partner. Evidence indicates that this shared partner, along with IKKalpha, interacts with and phosphorylates beta... | |
medium_convergence_07157 | CSNK2B and MAPK1 share multiple interacting partners. One specific shared partner is characterized by evidence stating: 'These two kinases were found to be associated in unstimulated PMN but dissociated upon activation of the cells by fMLP.' Which disease is linked to this specific shared partner via a biomarker relati... | Alzheimer disease | Medium | convergence | {"qa_id":"medium_convergence_07157","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and MAPK1 share multiple interacting partners. One specific shared partner is characterized by evidence stating: 'These two kinases were found to be a... | |
medium_convergence_07158 | Both Orthohepevirus A and Zika virus have been shown to downregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of approximately -1.765 and an adjusted p-value of 0.04032. Which protein is encoded by this gene? | F-box/LRR-repeat protein 18 | Medium | convergence | {"qa_id":"medium_convergence_07158","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Zika virus have been shown to downregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) r... | |
medium_convergence_07159 | HDAC1 and HDAC2 both interact with a shared protein partner. Experimental evidence indicates that Myt1 forms a complex with this shared partner, and this complex was co-immunoprecipitated from transfected mammalian cells, containing HDAC1 and HDAC2. Which protein is encoded by this shared partner? | Paired amphipathic helix protein Sin3b | Medium | convergence | {"qa_id":"medium_convergence_07159","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HDAC2 both interact with a shared protein partner. Experimental evidence indicates that Myt1 forms a complex with this shared partner, and this com... | |
medium_convergence_07160 | Human alphaherpesvirus 3 and Human mastadenovirus C both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately 2.28 and an adjusted p-value of approximately 0.037. Which protein is encoded by this gene? | E3 SUMO-protein ligase EGR2 | Medium | convergence | {"qa_id":"medium_convergence_07160","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Human mastadenovirus C both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586... | |
medium_convergence_07161 | FGFR3 and IFITM5 are both involved in a shared biological process. Evidence indicates that BRIL and PEDF have a relationship connecting the genes for types V and VI Osteogenesis Imperfecta (OI) to their roles in this specific process. Which biological process is this, and what is its parent term in the 'is_a' hierarchy... | biomineral tissue development | Medium | convergence | {"qa_id":"medium_convergence_07161","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGFR3 and IFITM5 are both involved in a shared biological process. Evidence indicates that BRIL and PEDF have a relationship connecting the genes for types V... | |
medium_convergence_07162 | The biological processes 'positive regulation of T-helper 2 cell differentiation' and 'positive regulation of T-helper 17 cell differentiation' share a common parent process in the ontology hierarchy. Evidence regarding one of these shared entities states: 'Any process that activates or increases the frequency, rate or... | T-helper cell differentiation | Medium | convergence | {"qa_id":"medium_convergence_07162","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'positive regulation of T-helper 2 cell differentiation' and 'positive regulation of T-helper 17 cell differentiation' share a commo... | |
medium_convergence_07163 | DLG3 and NLGN1 both interact with a common protein partner. Experimental evidence indicates that soluble neuroligins-1 bind to this partner (specifically the neurexin-1beta isoform), whereas acetylcholinesterase does not associate with it. Which disease is linked to this shared protein partner through genomic alteratio... | autism spectrum disorder | Medium | convergence | {"qa_id":"medium_convergence_07163","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG3 and NLGN1 both interact with a common protein partner. Experimental evidence indicates that soluble neuroligins-1 bind to this partner (specifically the... | |
medium_convergence_07164 | CTNNB1 and HDAC2 share multiple interacting partners. One such shared partner is described in the following evidence: 'Here we show that this protein forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtBP1 and regulates Wnt/β-catenin-dependent gene expression.' Which disease is associated with thi... | platelet-type bleeding disorder 17 | Medium | convergence | {"qa_id":"medium_convergence_07164","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and HDAC2 share multiple interacting partners. One such shared partner is described in the following evidence: 'Here we show that this protein forms c... | |
medium_convergence_07165 | YWHAQ and FGFR1 both interact with a specific shared protein. Evidence indicates that cytoplasmic protein 14-3-3 theta binds to this shared entity and, upon apoptotic stimulation, releases it via a caspase-independent mechanism, as well as through direct cleavage of 14-3-3 theta by caspases. Which protein is encoded by... | Apoptosis regulator BAX | Medium | convergence | {"qa_id":"medium_convergence_07165","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and FGFR1 both interact with a specific shared protein. Evidence indicates that cytoplasmic protein 14-3-3 theta binds to this shared entity and, upon ... | |
medium_convergence_07166 | PLK1 and YWHAE share multiple interacting partners. One such shared partner is characterized by evidence stating that it responds to the HER2 signaling cascade by translocating into the nucleus following Ser273 phosphorylation, and subsequently contributes to cell mitosis regulation by binding with PLK1 to promote the ... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_07166","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PLK1 and YWHAE share multiple interacting partners. One such shared partner is characterized by evidence stating that it responds to the HER2 signaling casca... | |
medium_convergence_07167 | PES1 and LAS1L both interact with a specific shared protein. Experimental evidence indicates that this shared protein, along with Bop1, co-immunoprecipitates with mutant M1 and M5 proteins associated with large pre-ribosomal complexes, demonstrating their proper incorporation into the PeBoW complex. Which protein is en... | Ribosome biogenesis protein WDR12 | Medium | convergence | {"qa_id":"medium_convergence_07167","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PES1 and LAS1L both interact with a specific shared protein. Experimental evidence indicates that this shared protein, along with Bop1, co-immunoprecipitates... | |
medium_convergence_07169 | Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE111036) show a log2 fold change of approximately -1.796 and an adjusted p-value of 0.04341. Which disease is associated with this gene as a biomarker? | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_07169","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE... | |
medium_convergence_07170 | YBX1 and PRKN (PARK2) share common interaction partners. One such shared partner is reported to form a complex with YBX1 to promote PFKFB4 transcription. Which cell type is this shared partner enriched in? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_07170","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YBX1 and PRKN (PARK2) share common interaction partners. One such shared partner is reported to form a complex with YBX1 to promote PFKFB4 transcription. Whi... | |
medium_convergence_07171 | CREB1 and CTNNB1 share multiple interacting partners. One such shared partner is implicated in a mechanism where S1P and PGE2 promote its direct interaction with CREB, a process potentiated by C/EBPdelta, CREB-binding protein (CBP), and steroid receptor coactivator-3 (SRC-3). Which protein is encoded by this shared int... | Nuclear receptor subfamily 5 group A member 2 | Medium | convergence | {"qa_id":"medium_convergence_07171","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREB1 and CTNNB1 share multiple interacting partners. One such shared partner is implicated in a mechanism where S1P and PGE2 promote its direct interaction ... | |
medium_convergence_07172 | ESR1 and ESR2 both interact with a shared protein entity. Evidence indicates that this entity is a variable component of the Mediator complex that enhances ligand-dependent ERα-mediated transcriptional activation of the CYP2C9 promoter and interacts with activated ERα via its C-terminal LXXLL motif. Which disease is as... | nephrolithiasis | Medium | convergence | {"qa_id":"medium_convergence_07172","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and ESR2 both interact with a shared protein entity. Evidence indicates that this entity is a variable component of the Mediator complex that enhances l... | |
medium_convergence_07173 | Both IKBKB and PRKCI interact with a common protein partner. A mechanistic study indicates that SKP2 acts as an adaptor to facilitate the interaction between active IKKβ and the autophagic cargo receptor encoded by SQSTM1, thereby mediating IKKβ degradation via selective autophagy. Which protein is encoded by the gene ... | Sequestosome-1 | Medium | convergence | {"qa_id":"medium_convergence_07173","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKB and PRKCI interact with a common protein partner. A mechanistic study indicates that SKP2 acts as an adaptor to facilitate the interaction between... | |
medium_convergence_07174 | FSTL3 and ACVR2A both interact with a shared protein entity. Evidence regarding this entity states: 'We hypothesized that, in addition to its canonical receptor ACVR2, activin A might similarly bind and signal via BMPR2.' Which protein is encoded by this shared entity? | Inhibin beta A chain | Medium | convergence | {"qa_id":"medium_convergence_07174","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FSTL3 and ACVR2A both interact with a shared protein entity. Evidence regarding this entity states: 'We hypothesized that, in addition to its canonical recep... | |
medium_convergence_07175 | EP300 and TP53 share multiple interacting partners. One such partner is described in evidence stating: 'Furthermore, [a specific DNA damage-associated protein] also associates with the acetyltransferase p300 and is required for efficient transcriptional activation of the p53 target gene p21 by affecting the acetylation... | SOSS complex subunit B1 | Medium | convergence | {"qa_id":"medium_convergence_07175","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and TP53 share multiple interacting partners. One such partner is described in evidence stating: 'Furthermore, [a specific DNA damage-associated protei... | |
medium_convergence_07176 | Both Enterovirus A and Rhinovirus A are known to downregulate the expression of a specific gene. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2 fold change of -1.756 and an adjusted p-value of 0.004348. Which protein interacts with this downregulated gene product? | SIAH1 | Medium | convergence | {"qa_id":"medium_convergence_07176","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Enterovirus A and Rhinovirus A are known to downregulate the expression of a specific gene. In a study of rhabdomyosarcoma cells (GSE103308), this gene ... | |
medium_convergence_07177 | GATA1 and GATA2 both interact with a specific transcription factor. Evidence indicates that the protein encoded by the gene LMO2 interacts directly with this transcription factor, as well as with the basic helix-loop-helix protein TAL1. Which protein is encoded by this transcription factor? | Rhombotin-2 | Medium | convergence | {"qa_id":"medium_convergence_07177","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA1 and GATA2 both interact with a specific transcription factor. Evidence indicates that the protein encoded by the gene LMO2 interacts directly with this... | |
medium_convergence_07178 | EHMT2 and EZH2 share common interaction partners. One such shared partner is described by the following evidence: 'Here we show that this protein binds histone lysine methyltransferase G9a, and both are co-localized in the nucleus in a cell-cycle-dependent manner.' Which protein is encoded by this shared interaction pa... | E3 ubiquitin-protein ligase UHRF1 | Medium | convergence | {"qa_id":"medium_convergence_07178","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and EZH2 share common interaction partners. One such shared partner is described by the following evidence: 'Here we show that this protein binds histo... | |
medium_convergence_07180 | CDH5 and CDH7 both interact with a shared protein partner. Evidence regarding this partner states: 'Using a mutant VE-cadherin lacking a highly conserved octapeptide, we demonstrated that it is required for the binding of this partner to VE-cadherin as determined by immunoprecipitation and colocalization studies.' Whic... | Catenin delta-1 | Medium | convergence | {"qa_id":"medium_convergence_07180","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDH5 and CDH7 both interact with a shared protein partner. Evidence regarding this partner states: 'Using a mutant VE-cadherin lacking a highly conserved oct... | |
medium_convergence_07182 | DMD and DTNB share multiple interacting partners. One such partner is described by the following evidence: 'Finally, we used in vitro translated proteins in an immunoprecipitation assay to show that, like beta 1-syntrophin, both beta 2- and alpha 1-syntrophin interact with peptides encoding the syntrophin-binding regio... | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_07182","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DMD and DTNB share multiple interacting partners. One such partner is described by the following evidence: 'Finally, we used in vitro translated proteins in ... | |
medium_convergence_07183 | PRMT5 and HDAC1 both interact with a specific shared protein. Evidence indicates that this shared protein contributes to germinal center formation and affinity maturation, at least in part, through its direct interaction with and methylation by PRMT5 at arginine 305 (R305). This modification is necessary for the full t... | B-cell lymphoma 6 protein | Medium | convergence | {"qa_id":"medium_convergence_07183","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRMT5 and HDAC1 both interact with a specific shared protein. Evidence indicates that this shared protein contributes to germinal center formation and affini... | |
medium_convergence_07184 | ASB10 and CUL5 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Finally, a stable complex containing Vif-CBFβ-EloB/C was purified in large quantity and shown to bind purified Cullin5.' Which protein is encoded by the gene corresponding to that shared entity? | Elongin-C | Medium | convergence | {"qa_id":"medium_convergence_07184","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ASB10 and CUL5 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Finally, a stable complex contain... | |
medium_convergence_07185 | NRP1 and CDC42 both interact with a specific protein. Evidence regarding this protein states: 'We have characterized the interactions of a 22-residue CRIB peptide derived from human [protein] [protein(71-92)] with Cdc42 using proton and heteronuclear NMR spectroscopy.' Which protein is this? | Serine/threonine-protein kinase PAK 2 | Medium | convergence | {"qa_id":"medium_convergence_07185","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NRP1 and CDC42 both interact with a specific protein. Evidence regarding this protein states: 'We have characterized the interactions of a 22-residue CRIB pe... | |
medium_convergence_07186 | ERP44 and PDIA3 share common interaction partners. One such partner is characterized by evidence stating it forms mixed disulfides with both hEROs and cargo folding intermediates. Which cell type is this specific partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_07186","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERP44 and PDIA3 share common interaction partners. One such partner is characterized by evidence stating it forms mixed disulfides with both hEROs and cargo ... | |
medium_convergence_07187 | Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific gene. Experimental data for this gene from study GSE131840 indicates a log2 fold change of approximately 3.42 and an adjusted p-value of approximately 4.17e-05. In which cellular component is the protein product of this gene located? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_07187","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific gene. Experimental data for this gene from study GSE131840 indicates a log2 f... | |
medium_convergence_07188 | ATM and TP53 both interact with a shared protein. Evidence indicates that this shared protein associates with a zinc finger protein in an HDACi-dependent manner, as revealed by co-immunoprecipitation. Which disease is associated with this shared protein? | global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies | Medium | convergence | {"qa_id":"medium_convergence_07188","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and TP53 both interact with a shared protein. Evidence indicates that this shared protein associates with a zinc finger protein in an HDACi-dependent man... | |
medium_convergence_07189 | Both Human mastadenovirus C and Enterovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a lung fibroblast cell line (study GSE120891) reports a log2 fold change of approximately 2.48 and an adjusted p-value of approximately 0.047. Which cell type is this gene enriched in? | mucosal-associated invariant T cell | Medium | convergence | {"qa_id":"medium_convergence_07189","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Enterovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a lung fibroblast cell line ... | |
medium_convergence_07190 | HLA-E and TAP1 both interact with a common protein partner. Evidence regarding this shared partner indicates that photolabeling experiments with 8-azido-ATP demonstrate a cooperative interaction between two nucleotide-binding domains (NBDs) that can be stimulated by peptide. Which disease is associated with this shared... | psoriasis | Medium | convergence | {"qa_id":"medium_convergence_07190","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HLA-E and TAP1 both interact with a common protein partner. Evidence regarding this shared partner indicates that photolabeling experiments with 8-azido-ATP ... | |
medium_convergence_07191 | MED1 and NCOR2 both interact with a shared protein. Evidence regarding this shared protein states: 'We show that SMRT interacts with the shared protein in glutathione S-transferase pull-down, yeast two-hybrid, and mammalian two-hybrid assays.' Which disease is therapeutically associated with this shared protein? | epilepsy | Medium | convergence | {"qa_id":"medium_convergence_07191","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED1 and NCOR2 both interact with a shared protein. Evidence regarding this shared protein states: 'We show that SMRT interacts with the shared protein in gl... | |
medium_convergence_07192 | Bivalirudin and Ticlopidine share a common interacting drug. Evidence regarding one such shared entity indicates that isobole analysis of its combination with Ticlopidine revealed synergism with potentiation in antithrombotic effects. Which disease is this specific shared drug indicated for? | heparin-induced thrombocytopenia | Medium | convergence | {"qa_id":"medium_convergence_07192","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Bivalirudin and Ticlopidine share a common interacting drug. Evidence regarding one such shared entity indicates that isobole analysis of its combination wit... | |
medium_convergence_07193 | NCOR1 and NCOR2 each interact with multiple shared partners. One such partner is described by the following evidence: 'Here we show that the pregnane X receptor interacts more strongly with SMRTalpha than with SMRTtau both in vitro and in vivo.' Which disease is therapeutically associated with this specific partner? | epilepsy | Medium | convergence | {"qa_id":"medium_convergence_07193","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCOR1 and NCOR2 each interact with multiple shared partners. One such partner is described by the following evidence: 'Here we show that the pregnane X recep... | |
medium_convergence_07194 | Both IPO7 and MYC interact with a common protein partner. Experimental evidence for this partner indicates that it forms stable complexes with several importins (including importin-β, importin-7, importin-β/7, importin-13, and transportin 1) and is imported into the nucleus in digitonin-permeabilized cells by these fac... | Nitric oxide synthase-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_07194","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IPO7 and MYC interact with a common protein partner. Experimental evidence for this partner indicates that it forms stable complexes with several import... | |
medium_convergence_07195 | CSNK2B and MAPK1 both interact with a shared protein. Evidence regarding this shared protein states: 'These two kinases were found to be associated in unstimulated PMN but dissociated upon activation of the cells by fMLP.' Which protein is encoded by the gene corresponding to this shared entity? | MAP kinase-activated protein kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_07195","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and MAPK1 both interact with a shared protein. Evidence regarding this shared protein states: 'These two kinases were found to be associated in unstim... | |
medium_convergence_07196 | EP300 and XRCC6 both interact with a shared protein. Evidence indicates that a non-phosphorylatable mutant of p300 (S106A) destabilizes this shared protein and reduces the interaction between this shared protein and p300. Which cell type is enriched for this shared protein? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_07196","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and XRCC6 both interact with a shared protein. Evidence indicates that a non-phosphorylatable mutant of p300 (S106A) destabilizes this shared protein a... | |
medium_convergence_07197 | BET1 and ARCN1 both interact with a shared protein partner. Experimental evidence for this interaction includes immunoprecipitation and two-hybrid analysis within a complete COP screen, which demonstrated physical interactions between alpha- and epsilon-COPs, as well as between beta- and delta-COPs. Which protein is en... | Coatomer subunit beta | Medium | convergence | {"qa_id":"medium_convergence_07197","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BET1 and ARCN1 both interact with a shared protein partner. Experimental evidence for this interaction includes immunoprecipitation and two-hybrid analysis w... | |
medium_convergence_07198 | TRAF3IP2 and AKT1 both interact with a shared protein. Experimental evidence indicates that IL-17 stimulation activates this shared protein and induces its association with Act1. Which protein is encoded by the gene corresponding to this shared entity? | Serine/threonine-protein kinase TBK1 | Medium | convergence | {"qa_id":"medium_convergence_07198","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRAF3IP2 and AKT1 both interact with a shared protein. Experimental evidence indicates that IL-17 stimulation activates this shared protein and induces its a... | |
medium_convergence_07200 | CHEK1 and KPNA2 share a common interacting partner. Evidence indicates that this shared partner binds Chk1 and dephosphorylates the ATR-targeted phospho-Ser 345 residue, resulting in decreased Chk1 kinase activity. Which protein is encoded by the gene corresponding to this shared interacting partner? | Protein phosphatase 1D | Medium | convergence | {"qa_id":"medium_convergence_07200","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and KPNA2 share a common interacting partner. Evidence indicates that this shared partner binds Chk1 and dephosphorylates the ATR-targeted phospho-Ser ... | |
medium_convergence_07201 | CENPA and BUB3 share multiple binding partners. One such shared partner is part of a complex described as follows: 'Here, we show that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (CENP-M, CENP-N and CENP-T), along with CENP-U... | Centromere protein N | Medium | convergence | {"qa_id":"medium_convergence_07201","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and BUB3 share multiple binding partners. One such shared partner is part of a complex described as follows: 'Here, we show that CENP-A nucleosomes dir... | |
medium_convergence_07202 | CREBBP and FOXG1 both interact with a specific transcription factor. Evidence indicates that the CR2C and CR3 regions of this factor's isoform 'a' interact with the KIX domain of CBP/p300 at both 'MLL' and 'c-Myb' binding sites simultaneously. Which protein is encoded by this transcription factor? | Forkhead box protein O3 | Medium | convergence | {"qa_id":"medium_convergence_07202","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and FOXG1 both interact with a specific transcription factor. Evidence indicates that the CR2C and CR3 regions of this factor's isoform 'a' interact w... | |
medium_convergence_07203 | Both West Nile virus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific gene. Experimental data from monocyte-derived dendritic cells (study GSE136342) indicates that for one such shared target, the log2 fold change is approximately 1.045 and the adjusted p-value is 0.004282. W... | Interferon-induced protein with tetratricopeptide repeats 5 | Medium | convergence | {"qa_id":"medium_convergence_07203","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific gene. Experimental data from monocyte-deriv... | |
medium_convergence_07204 | Both Human alphaherpesvirus 1 and Dengue virus have been shown to downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately -1.044 and an adjusted p-value of 0.005865. Which protein is encoded by this gene? | Annexin A3 | Medium | convergence | {"qa_id":"medium_convergence_07204","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Dengue virus have been shown to downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell ... | |
medium_convergence_07205 | CHUK and FLNA share interaction partners. One such partner is described in a study stating: 'We demonstrated, for the first time, that inhibitor of nuclear factor κ-B kinase (IKK) interacted with this protein and regulated mTORC2 activity.' Which cell type is this protein enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_07205","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and FLNA share interaction partners. One such partner is described in a study stating: 'We demonstrated, for the first time, that inhibitor of nuclear f... | |
medium_convergence_07206 | Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of -2.636 and an adjusted p-value of 0.003649. Which disease is associated with this gene? | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_07206","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene in macrophages (fr... | |
medium_convergence_07207 | NCF2 and NCF1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Here we identify a novel domain PB1 in the budding yeast protein Bem1p, which functions in polarity establishment, and mammalian p67(phox), which activates the microbicidal phagocyte NADPH ox... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_07207","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCF2 and NCF1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Here we identify a novel dom... | |
medium_convergence_07208 | EGFR and GRB2 share multiple binding partners. One such shared partner is an intracellular protein that binds the adaptor protein GRB2, a feature consistent with its intracellular localization. Which cell type is this shared protein enriched in? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_07208","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and GRB2 share multiple binding partners. One such shared partner is an intracellular protein that binds the adaptor protein GRB2, a feature consistent ... | |
medium_convergence_07209 | SIRT1 and HSP90AA1 both interact with a specific gene product. Evidence indicates that endogenous Hsp90 interacts with this product in DLBCL cells, stabilizing its mRNA and protein. Which protein is encoded by this gene product? | B-cell lymphoma 6 protein | Medium | convergence | {"qa_id":"medium_convergence_07209","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIRT1 and HSP90AA1 both interact with a specific gene product. Evidence indicates that endogenous Hsp90 interacts with this product in DLBCL cells, stabilizi... | |
medium_convergence_07210 | HDAC1 and HDAC3 both interact with a specific transcriptional corepressor. Evidence indicates that interactions between Groucho and this corepressor are enhanced by the sumoylation of Groucho, a process mediated by the SUMO-interaction motif of the corepressor. Which cell type is this corepressor enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_07210","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HDAC3 both interact with a specific transcriptional corepressor. Evidence indicates that interactions between Groucho and this corepressor are enha... | |
medium_convergence_07211 | YAP1 and YWHAQ share a common interaction partner. Evidence regarding this shared partner states: 'In this study, we show that the kinase corresponding to the shared partner directly phosphorylates Yap1 at position Y357 in response to DNA damage.' Which protein is encoded by the gene corresponding to this shared intera... | Tyrosine-protein kinase ABL1 | Medium | convergence | {"qa_id":"medium_convergence_07211","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and YWHAQ share a common interaction partner. Evidence regarding this shared partner states: 'In this study, we show that the kinase corresponding to th... | |
medium_convergence_07212 | DDX39A and CSTF1 both interact with a shared protein partner. Experimental evidence indicates that Co-immunoprecipitation and mass spectrometry analyses identified a primary interacting protein for DDX39. Which protein product is encoded by this shared partner? | SAP domain-containing ribonucleoprotein | Medium | convergence | {"qa_id":"medium_convergence_07212","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX39A and CSTF1 both interact with a shared protein partner. Experimental evidence indicates that Co-immunoprecipitation and mass spectrometry analyses iden... | |
medium_convergence_07213 | FGF1 and FGF23 both interact with a common protein partner. Experimental evidence for this partner includes the statement: 'We have crystallized a complex between human [the partner] and a two-domain extracellular fragment of human [the partner].' Which protein is encoded by the gene corresponding to this partner? | Fibroblast growth factor receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_07213","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF1 and FGF23 both interact with a common protein partner. Experimental evidence for this partner includes the statement: 'We have crystallized a complex be... | |
medium_convergence_07214 | NEDD4 and YWHAB both interact with a shared gene product. Evidence regarding one such shared entity states: 'Here we identify Nedd4 as an IRS-2 ubiquitin ligase.' Which gene interacts with this specific shared entity? | USP15 | Medium | convergence | {"qa_id":"medium_convergence_07214","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4 and YWHAB both interact with a shared gene product. Evidence regarding one such shared entity states: 'Here we identify Nedd4 as an IRS-2 ubiquitin lig... | |
medium_convergence_07215 | STUB1 and HSPA8 share multiple interacting partners. One such shared partner is implicated in the following context: 'In addition, two cochaperones, the C terminus of Hsp70-interacting protein (CHIP) and the Hsp70/Hsp90 organizer protein, were associated with the thiazide-sensitive sodium-chloride cotransporter.' Which... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_07215","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and HSPA8 share multiple interacting partners. One such shared partner is implicated in the following context: 'In addition, two cochaperones, the C te... | |
medium_convergence_07216 | CNTROB and PABPC1 both interact with a shared protein entity. Evidence indicates that a single amino acid substitution in the PAM2 motif of this shared entity abolishes its interaction with PABPC1. Which protein is encoded by this shared entity? | Trinucleotide repeat-containing gene 6A protein | Medium | convergence | {"qa_id":"medium_convergence_07216","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNTROB and PABPC1 both interact with a shared protein entity. Evidence indicates that a single amino acid substitution in the PAM2 motif of this shared entit... | |
medium_convergence_07217 | CDK9 and YAP1 share multiple interacting partners. One such shared partner is reported to directly interact with YAP1 via a WB motif-WW domain interaction. Which protein is encoded by this specific shared partner? | Poly(rC)-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_07217","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK9 and YAP1 share multiple interacting partners. One such shared partner is reported to directly interact with YAP1 via a WB motif-WW domain interaction. W... | |
medium_convergence_07218 | IKBKB and CD14 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'We show that MUC1 interacts with the high-molecular-weight IkappaB kinase (IKK) complex in vivo and that the MUC1 cytoplasmic domain binds directly to IKKbeta and IKKgamma.' Which protein is encod... | NF-kappa-B essential modulator | Medium | convergence | {"qa_id":"medium_convergence_07218","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IKBKB and CD14 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'We show that MUC1 interacts with ... |
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