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medium_convergence_07219 | KIF26A and ULK4 are both associated with multiple shared biological processes. Evidence regarding one of these shared entities states: 'Combining mice and human iPSC-derived organoid models, we discovered that loss of KIF26A causes excitatory neuron-specific defects in radial migration, localization, dendritic and axon... | neuron migration | Medium | convergence | {"qa_id":"medium_convergence_07219","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KIF26A and ULK4 are both associated with multiple shared biological processes. Evidence regarding one of these shared entities states: 'Combining mice and hu... | |
medium_convergence_07220 | CAMK2D and CAMK2G both interact with a shared protein partner. Evidence indicates that the loss of PTENα impairs the interaction between CaMKII and this shared partner, resulting in deficits in hippocampal long-term potentiation, fear-conditioned memory, and spatial learning. Which disease is therapeutically linked to ... | fetal growth restriction | Medium | convergence | {"qa_id":"medium_convergence_07220","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAMK2D and CAMK2G both interact with a shared protein partner. Evidence indicates that the loss of PTENα impairs the interaction between CaMKII and this shar... | |
medium_convergence_07222 | CDK2 and CHEK2 both interact with a specific phosphatase gene. Experimental evidence regarding this gene's protein product indicates that a Cys-to-Ser mutant of this protein interacts strongly with cyclin A-Cdk2, cyclin B-Cdc2, and cyclin E-Cdk2, whereas a Cdc25B mutant was found to bind significantly only to cyclin A-... | M-phase inducer phosphatase 1 | Medium | convergence | {"qa_id":"medium_convergence_07222","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and CHEK2 both interact with a specific phosphatase gene. Experimental evidence regarding this gene's protein product indicates that a Cys-to-Ser mutant... | |
medium_convergence_07223 | CTBP2 and PACS2 both interact with a specific shared protein. Evidence regarding this interaction states: 'We found that [the shared protein] interacts with CtBP2 via through BIR domains to regulates the steady-state levels of CtBP2 protein in the nucleus.' Which protein is encoded by this shared entity? | Baculoviral IAP repeat-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_07223","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP2 and PACS2 both interact with a specific shared protein. Evidence regarding this interaction states: 'We found that [the shared protein] interacts with ... | |
medium_convergence_07224 | PCGF2 and PCGF5 both interact with a specific protein. Biochemical evidence indicates that this protein, along with its homolog YAF2, associates with PCGF-RING1A/B combinations to form complexes that prevent the incorporation of canonical PRC1 subunits such as CBX, PHC, and SCM. Which protein is encoded by the gene cor... | RING1 and YY1-binding protein | Medium | convergence | {"qa_id":"medium_convergence_07224","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCGF2 and PCGF5 both interact with a specific protein. Biochemical evidence indicates that this protein, along with its homolog YAF2, associates with PCGF-RI... | |
medium_convergence_07225 | ITCH and ATG12 both interact with a shared protein. Evidence indicates that TAX1BP1 recruits the E3 ligase ITCH to this shared protein to trigger its ubiquitination and degradation, and that loss of either TAX1BP1 or ITCH leads to increased expression of this shared protein. Which protein is encoded by the gene corresp... | Mitochondrial antiviral-signaling protein | Medium | convergence | {"qa_id":"medium_convergence_07225","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ITCH and ATG12 both interact with a shared protein. Evidence indicates that TAX1BP1 recruits the E3 ligase ITCH to this shared protein to trigger its ubiquit... | |
medium_convergence_07226 | Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific gene. In a study of pleural mesothelioma cells (GSE117668), this gene exhibited a log2 fold change of approximately 3.25 and an adjusted p-value of 0.0089. What is the name of the protein encoded by this gene? | 2'-5'-oligoadenylate synthase 3 | Medium | convergence | {"qa_id":"medium_convergence_07226","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific gene. In a study of pleural mesothelioma cells (GSE117668), t... | |
medium_convergence_07227 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.72 and an adjusted p-value of approximately 0.0013. Which protein does this gene product interact with? | VIL1 | Medium | convergence | {"qa_id":"medium_convergence_07227","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2... | |
medium_convergence_07228 | Anistreplase and Streptokinase share a common interacting drug. Evidence indicates that this shared drug, at therapeutic concentrations (10-50 µg/ml), blocked Streptokinase- and GAS-induced fibrinolysis. Which disease is this shared drug indicated for? | hemophilia | Medium | convergence | {"qa_id":"medium_convergence_07228","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Anistreplase and Streptokinase share a common interacting drug. Evidence indicates that this shared drug, at therapeutic concentrations (10-50 µg/ml), blocke... | |
medium_convergence_07229 | ATP6V1E1 and ATP6V1E2 both interact with a common protein partner. Experimental evidence states: 'We searched for proteins that bind to the E subunit of V-ATPase using the yeast two-hybrid assay and identified the H subunit as an interacting partner.' Which protein is encoded by the gene corresponding to this interacti... | V-type proton ATPase subunit H | Medium | convergence | {"qa_id":"medium_convergence_07229","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATP6V1E1 and ATP6V1E2 both interact with a common protein partner. Experimental evidence states: 'We searched for proteins that bind to the E subunit of V-AT... | |
medium_convergence_07230 | Estradiol and topical Dienestrol both interact with a specific shared entity. Clinical evidence indicates that Letrozole results in higher testosterone levels and lower levels of this shared entity compared to the entity itself. Which disease is this shared entity indicated for? | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_07230","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Estradiol and topical Dienestrol both interact with a specific shared entity. Clinical evidence indicates that Letrozole results in higher testosterone level... | |
medium_convergence_07231 | GH1 and JAK2 both interact with a shared protein partner. Experimental evidence indicates that the interaction between this shared partner and JAK2 is impaired, as demonstrated by a lack of co-immunoprecipitation. Which disease is associated with this shared protein partner through genomic alterations? | breast benign neoplasm | Medium | convergence | {"qa_id":"medium_convergence_07231","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GH1 and JAK2 both interact with a shared protein partner. Experimental evidence indicates that the interaction between this shared partner and JAK2 is impair... | |
medium_convergence_07232 | IKZF1 and DDB1 share a common interacting partner. Contextual evidence indicates that this partner, when bound by lenalidomide, acquires the ability to target specific B cell transcription factors, including IKZF1 and IKZF3, for proteasomal degradation. Which protein is encoded by the gene corresponding to this shared ... | Protein cereblon | Medium | convergence | {"qa_id":"medium_convergence_07232","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IKZF1 and DDB1 share a common interacting partner. Contextual evidence indicates that this partner, when bound by lenalidomide, acquires the ability to targe... | |
medium_convergence_07233 | PHC1 and PCGF2 both interact with a shared protein. Biochemical evidence indicates that this protein (or its homolog YAF2) associates with PCGF-RING1A/B combinations to form complexes that prevent the incorporation of other canonical PRC1 subunits, such as CBX, PHC, and SCM. Which gene encodes this shared protein? | RING1 and YY1-binding protein | Medium | convergence | {"qa_id":"medium_convergence_07233","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PHC1 and PCGF2 both interact with a shared protein. Biochemical evidence indicates that this protein (or its homolog YAF2) associates with PCGF-RING1A/B comb... | |
medium_convergence_07234 | NUP188 and KPNB1 both interact with a common protein. Evidence regarding this shared partner states: 'The import reaction is terminated by the direct binding of nuclear RanGTP to importin-beta which dissociates the importin heterodimer.' Which disease is associated with this shared protein through genomic alterations? | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_07234","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUP188 and KPNB1 both interact with a common protein. Evidence regarding this shared partner states: 'The import reaction is terminated by the direct binding... | |
medium_convergence_07235 | HSP90AA1 and CD14 share multiple binding partners. One of these shared partners is specifically described as a client protein of Hsp90 in vivo. Which cell type is enriched for this specific shared partner? | basophil | Medium | convergence | {"qa_id":"medium_convergence_07235","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and CD14 share multiple binding partners. One of these shared partners is specifically described as a client protein of Hsp90 in vivo. Which cell ty... | |
medium_convergence_07236 | Human polyomavirus 1 and Primate bocaparvovirus 1 each upregulate more than one shared gene. Evidence concerning one such shared entity reports a log2 fold change of 1.602 and an adjusted p-value of 1.88e-05. Which disease is connected to that entity through genomic alterations? | amyotrophic lateral sclerosis | Medium | convergence | {"qa_id":"medium_convergence_07236","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Primate bocaparvovirus 1 each upregulate more than one shared gene. Evidence concerning one such shared entity reports a log2 fold c... | |
medium_convergence_07237 | EP300 and HIF1A both interact with a specific shared protein. Evidence indicates that the lysine acetyltransferase p300 targets this protein at lysine 40 (K40) for acetylation, a modification that is reversed by the deacetylase SIRT3. Which disease is associated with this protein through genomic alterations? | follicular lymphoma | Medium | convergence | {"qa_id":"medium_convergence_07237","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and HIF1A both interact with a specific shared protein. Evidence indicates that the lysine acetyltransferase p300 targets this protein at lysine 40 (K4... | |
medium_convergence_07238 | TRIM38 and PRKN (PARK2) share common interacting partners. One such shared partner is described as directly binding to galectin-3-binding protein (LGALS3BP) and forming a complex with the E3 ubiquitin ligase TRIM38, thereby facilitating the ubiquitination-mediated degradation of LGALS3BP at the K104 residue. Which prot... | Ubiquitin-conjugating enzyme E2 G2 | Medium | convergence | {"qa_id":"medium_convergence_07238","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM38 and PRKN (PARK2) share common interacting partners. One such shared partner is described as directly binding to galectin-3-binding protein (LGALS3BP) ... | |
medium_convergence_07239 | Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately 1.77 and an adjusted p-value of approximately 0.0031. Which protein is encoded by this gene? | Transcription factor A, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_07239","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_07240 | RAD50 and XRCC6 both interact with a specific shared protein. Evidence indicates that this shared protein is a novel Ku70-interacting protein identified by yeast two-hybrid screening. Which protein is encoded by this shared entity? | DNA mismatch repair protein Msh6 | Medium | convergence | {"qa_id":"medium_convergence_07240","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD50 and XRCC6 both interact with a specific shared protein. Evidence indicates that this shared protein is a novel Ku70-interacting protein identified by y... | |
medium_convergence_07241 | SMAD7 and BMPR2 both interact with a common protein partner. Experimental evidence indicates that this partner interacts with TβRI and SMAD7, leading to increased ubiquitination levels of both TβRI and SMAD7. Which protein is encoded by the gene corresponding to this partner? | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_07241","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD7 and BMPR2 both interact with a common protein partner. Experimental evidence indicates that this partner interacts with TβRI and SMAD7, leading to incr... | |
medium_convergence_07242 | CBL and FGF17 both interact with a shared protein entity. Evidence regarding this entity states: 'Here, we demonstrate that Grb2 bound to tyrosine-phosphorylated [Entity] alpha forms a ternary complex with Cbl by means of its Src homology 3 domains resulting in the ubiquitination of fibroblast growth factor (FGF) recep... | Fibroblast growth factor receptor substrate 2 | Medium | convergence | {"qa_id":"medium_convergence_07242","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBL and FGF17 both interact with a shared protein entity. Evidence regarding this entity states: 'Here, we demonstrate that Grb2 bound to tyrosine-phosphoryl... | |
medium_convergence_07243 | EP300 and NFIB share interaction partners. One such shared partner is described in evidence stating that a zinc finger protein physically associates with the histone acetyltransferases p300 and Gcn5/Trrap, and occupies common sites with Gcn5 within the human globin loci. Which protein is encoded by the gene correspondi... | Zinc finger protein 148 | Medium | convergence | {"qa_id":"medium_convergence_07243","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and NFIB share interaction partners. One such shared partner is described in evidence stating that a zinc finger protein physically associates with the... | |
medium_convergence_07244 | CEP55 and YWHAE share common interaction partners. One such shared partner interacts with CEP55 via a short GPPXXXY motif, a mechanism analogous to that used by endosomal sorting complex required for transport-I components. Which protein is encoded by this shared interaction partner? | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 | Medium | convergence | {"qa_id":"medium_convergence_07244","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEP55 and YWHAE share common interaction partners. One such shared partner interacts with CEP55 via a short GPPXXXY motif, a mechanism analogous to that used... | |
medium_convergence_07245 | Glucagon and Octreotide both interact with a specific beta-blocker. Clinical evidence regarding this beta-blocker includes a randomized trial titled 'High-Dose Glucagon Has Hemodynamic Effects Regardless of Cardiac Beta-Adrenoceptor Blockade'. Which disease is this beta-blocker indicated for? | atrial flutter | Medium | convergence | {"qa_id":"medium_convergence_07245","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Glucagon and Octreotide both interact with a specific beta-blocker. Clinical evidence regarding this beta-blocker includes a randomized trial titled 'High-Do... | |
medium_convergence_07246 | DNMT1 and UHRF1 share multiple interaction partners. One such shared partner is implicated in a study where proteomic analysis of immunoprecipitates revealed its association with the epigenetic machinery, specifically DNMT1, UHRF1, G9a, and the transcription factor Snail1. Which protein is encoded by this shared intera... | LIM and SH3 domain protein 1 | Medium | convergence | {"qa_id":"medium_convergence_07246","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT1 and UHRF1 share multiple interaction partners. One such shared partner is implicated in a study where proteomic analysis of immunoprecipitates revealed... | |
medium_convergence_07247 | STUB1 and GSK3B both interact with a specific shared protein. Evidence indicates that the extreme C-terminal sequence of this shared protein plays an indispensable role in its direct association with the tetratricopeptide repeat (TPR) domain of CHIP. Which protein is encoded by the gene corresponding to this shared ent... | SMAD family member 1 | Medium | convergence | {"qa_id":"medium_convergence_07247","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and GSK3B both interact with a specific shared protein. Evidence indicates that the extreme C-terminal sequence of this shared protein plays an indispe... | |
medium_convergence_07248 | CEBPA and KHDRBS1 share common interaction partners. One such shared partner is implicated in evidence stating that Sam68 and a histone acetyltransferase interact in vivo and colocalize in nuclear sub-domains. Which protein is encoded by this shared partner? | CREB-binding protein | Medium | convergence | {"qa_id":"medium_convergence_07248","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPA and KHDRBS1 share common interaction partners. One such shared partner is implicated in evidence stating that Sam68 and a histone acetyltransferase int... | |
medium_convergence_07249 | EAF1 and CCNK both interact with a shared protein partner. Experimental evidence indicates that endogenous EAF1 and this shared partner were co-immunoprecipitated from multiple cell lines using specific antibodies. Which disease is associated with this shared partner through genomic alterations? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_07249","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EAF1 and CCNK both interact with a shared protein partner. Experimental evidence indicates that endogenous EAF1 and this shared partner were co-immunoprecipi... | |
medium_convergence_07252 | CDK4 and CCND1 share multiple binding partners. One such partner is characterized by evidence showing that Thr172-phosphorylated CDK4 is enriched in complexes containing p21 or p27, even at inhibitory levels of p27 that preclude CDK4 activity. Which disease is genetically associated with this specific shared partner? | melanocytic nevus | Medium | convergence | {"qa_id":"medium_convergence_07252","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK4 and CCND1 share multiple binding partners. One such partner is characterized by evidence showing that Thr172-phosphorylated CDK4 is enriched in complexe... | |
medium_convergence_07254 | EP300 and RPA2 share common interaction partners. One such shared partner is described in evidence stating: 'The [shared partner]-associated proteins included RPA1 and RPA2, two components of the replication protein A (RPA) complex.' Which disease is associated with this specific shared entity via genomic alterations? | lupus vulgaris | Medium | convergence | {"qa_id":"medium_convergence_07254","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and RPA2 share common interaction partners. One such shared partner is described in evidence stating: 'The [shared partner]-associated proteins include... | |
medium_convergence_07255 | MAPRE1 and SNCA share a common interacting partner. Evidence for one such partner states: 'A direct interaction between α-synuclein and this protein was confirmed by GST pull-down and co-immunoprecipitation assays.' Which protein is encoded by this interacting partner? | Spectrin beta chain, non-erythrocytic 1 | Medium | convergence | {"qa_id":"medium_convergence_07255","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPRE1 and SNCA share a common interacting partner. Evidence for one such partner states: 'A direct interaction between α-synuclein and this protein was conf... | |
medium_convergence_07257 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.817 and an adjusted p-value of 0.004662. Which protein is encoded by this gene? | Creatine kinase B-type | Medium | convergence | {"qa_id":"medium_convergence_07257","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (stud... | |
medium_convergence_07258 | CHAF1A and DAXX share multiple interaction partners. One such shared partner is a histone variant encoded by a gene whose protein product forms an H3.3-H4 heterodimer. Evidence indicates that the histone-binding domain of DAXX binds this heterodimer, making extensive contacts with both H3.3 and H4. Which disease is ass... | childhood oligodendroglioma | Medium | convergence | {"qa_id":"medium_convergence_07258","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHAF1A and DAXX share multiple interaction partners. One such shared partner is a histone variant encoded by a gene whose protein product forms an H3.3-H4 he... | |
medium_convergence_07259 | ANAPC13 and CDC20 both interact with a shared protein complex component. Experimental evidence indicates that in extracts from M phase HeLa cells (but not interphase), p55CDC coimmunoprecipitates with this shared entity, along with Cdc16 and Mad2. Which gene product interacts with this shared entity? | CDH1 | Medium | convergence | {"qa_id":"medium_convergence_07259","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC13 and CDC20 both interact with a shared protein complex component. Experimental evidence indicates that in extracts from M phase HeLa cells (but not in... | |
medium_convergence_07260 | Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Evidence for this shared target includes a log2 fold change of approximately -1.057 and an adjusted p-value of 0.00396. Which protein is encoded by this gene? | FAST kinase domain-containing protein 1, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_07260","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Evidence for this shared target includes a log2 fold ... | |
medium_convergence_07261 | YWHAQ and SFN share a common interaction partner. Evidence regarding this shared entity states: 'The nuclear-to-cytoplasmic translocation was mediated by phosphorylation-dependent [entity] binding to 14-3-3theta but not 14-3-3beta or -sigma.' Which biological process is this entity involved in? | negative regulation of G2/M transition of mitotic cell cycle | Medium | convergence | {"qa_id":"medium_convergence_07261","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and SFN share a common interaction partner. Evidence regarding this shared entity states: 'The nuclear-to-cytoplasmic translocation was mediated by pho... | |
medium_convergence_07262 | Both KRAS and STX4 interact with multiple shared gene products. One such shared entity is supported by evidence stating: 'Using microcapillary reverse-phase high-performance liquid chromatography-nano-electrospray tandem mass spectrometry, we identified VAMP-3 and VAMP-8 as VAMP isoforms coimmunoprecipitated from plate... | Vesicle-associated membrane protein 3 | Medium | convergence | {"qa_id":"medium_convergence_07262","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both KRAS and STX4 interact with multiple shared gene products. One such shared entity is supported by evidence stating: 'Using microcapillary reverse-phase ... | |
medium_convergence_07264 | HDAC1 and JUN both interact with a shared protein. Evidence indicates that nuclear Bcl-3 associates with STAT-1 and histone deacetylase 1 (HDAC-1), increasing HDAC-1 recruitment to the IL-8 promoter. Which protein is encoded by the gene corresponding to this shared entity? | B-cell lymphoma 3 protein | Medium | convergence | {"qa_id":"medium_convergence_07264","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and JUN both interact with a shared protein. Evidence indicates that nuclear Bcl-3 associates with STAT-1 and histone deacetylase 1 (HDAC-1), increasin... | |
medium_convergence_07265 | ARF6 and BCAR1 both interact with a specific protein. Evidence indicates that disrupting the binding between CAS and this protein blocks downstream effectors of the actin cytoskeleton and focal adhesion assembly, inhibits cell migration, and disrupts survival signals leading to apoptosis. Which protein is encoded by th... | Adapter molecule crk | Medium | convergence | {"qa_id":"medium_convergence_07265","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARF6 and BCAR1 both interact with a specific protein. Evidence indicates that disrupting the binding between CAS and this protein blocks downstream effectors... | |
medium_convergence_07266 | CBX3 and CBX5 share a common interaction partner. Evidence indicates that this shared partner interacts with HP1 isoforms α and β, but not with HP1γ. Which cellular component is this shared partner located in? | mitotic spindle | Medium | convergence | {"qa_id":"medium_convergence_07266","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and CBX5 share a common interaction partner. Evidence indicates that this shared partner interacts with HP1 isoforms α and β, but not with HP1γ. Which c... | |
medium_convergence_07267 | POLH and RFC3 share common binding partners. One such partner is described as binding to replicative DNA polymerase POLD3 and PDIP1 under normal conditions, but preferentially associating with TLS polymerase η (POLH) upon UV damage. Which protein is encoded by this specific shared partner? | DNA-dependent metalloprotease SPRTN | Medium | convergence | {"qa_id":"medium_convergence_07267","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLH and RFC3 share common binding partners. One such partner is described as binding to replicative DNA polymerase POLD3 and PDIP1 under normal conditions, ... | |
medium_convergence_07268 | Rhinovirus A and Primate bocaparvovirus 1 both downregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a log2 fold change of -3.665 and an adjusted p-value of 0.002104. Which cellular component is this gene located in? | cytosol | Medium | convergence | {"qa_id":"medium_convergence_07268","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Primate bocaparvovirus 1 both downregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a... | |
medium_convergence_07269 | ADRM1 and PSMC4 both interact with a shared protein partner. Evidence indicates that this partner was identified as gankyrin, a liver oncoprotein, in a yeast two-hybrid screen involving the human S6 (TBP7, RPT3) ATPase of the 26 S proteasome. Which disease is associated with this shared protein partner? | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_07269","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRM1 and PSMC4 both interact with a shared protein partner. Evidence indicates that this partner was identified as gankyrin, a liver oncoprotein, in a yeast... | |
medium_convergence_07270 | JAK2 and KITLG both interact with a common protein partner. Experimental evidence regarding this partner indicates that direct binding and covalent cross-linking of radiolabeled Stem Cell Factor (SCF) demonstrated that the protein fully retained high-affinity ligand binding and underwent efficient dimerization in the p... | Mast/stem cell growth factor receptor Kit | Medium | convergence | {"qa_id":"medium_convergence_07270","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JAK2 and KITLG both interact with a common protein partner. Experimental evidence regarding this partner indicates that direct binding and covalent cross-lin... | |
medium_convergence_07271 | GH2 and JAK2 each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that the interaction between this protein and JAK2 is impaired, as evidenced by a lack of co-immunoprecipitation. Which protein is connected to that entity through the 'encodes' relationship? | Prolactin receptor | Medium | convergence | {"qa_id":"medium_convergence_07271","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GH2 and JAK2 each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that the interaction between this prot... | |
medium_convergence_07272 | Urokinase and Eptifibatide share a common interacting drug. Evidence indicates that PKSI-527, anti-uPA, and anti-tPA IgGs suppressed thrombolysis induced by this shared entity. Which disease is this entity indicated for? | heparin-induced thrombocytopenia | Medium | convergence | {"qa_id":"medium_convergence_07272","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Urokinase and Eptifibatide share a common interacting drug. Evidence indicates that PKSI-527, anti-uPA, and anti-tPA IgGs suppressed thrombolysis induced by ... | |
medium_convergence_07273 | FYN and MAP2K7 share multiple binding partners. One such shared partner is described in evidence stating: 'Both DLK and a mitogen-activated protein kinase kinase kinase associated with, phosphorylated, and activated MKK7 in vitro.' Which disease is associated with this specific shared partner? | Aarskog-Scott syndrome, X-linked | Medium | convergence | {"qa_id":"medium_convergence_07273","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and MAP2K7 share multiple binding partners. One such shared partner is described in evidence stating: 'Both DLK and a mitogen-activated protein kinase ki... | |
medium_convergence_07274 | RPA1 and STX1A share common interacting partners. One such shared partner forms a trans-SNARE complex with syntaxin1 that excludes SNAP23, SNAP25, and SNAP29, and this complex does not mediate membrane fusion. Which protein is encoded by the gene corresponding to this specific shared partner? | Vesicle-trafficking protein SEC22b | Medium | convergence | {"qa_id":"medium_convergence_07274","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPA1 and STX1A share common interacting partners. One such shared partner forms a trans-SNARE complex with syntaxin1 that excludes SNAP23, SNAP25, and SNAP29... | |
medium_convergence_07277 | HRAS and KSR1 both interact with a specific protein. Evidence indicates that the Ras transforming activity correlates best with the ability of the encoded protein to interact with this protein. Which cell type is this protein enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_07277","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HRAS and KSR1 both interact with a specific protein. Evidence indicates that the Ras transforming activity correlates best with the ability of the encoded pr... | |
medium_convergence_07279 | ERBB4 and ANLN share a common interaction partner. Evidence indicates that in the absence of GWRQ, trophinin interacts with the cytoplasmic protein bystin, which binds to this shared entity and blocks its autophosphorylation. Which cell type is enriched for this shared entity? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_07279","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB4 and ANLN share a common interaction partner. Evidence indicates that in the absence of GWRQ, trophinin interacts with the cytoplasmic protein bystin, w... | |
medium_convergence_07280 | CENPH and HIST1H4A share multiple binding partners. One of these shared partners is described as binding at a stoichiometric ratio to the CENP-A/H4 tetramer but not to the H3/H4 tetramer. Which disease is associated with this specific shared partner? | astrocytoma (excluding glioblastoma) | Medium | convergence | {"qa_id":"medium_convergence_07280","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPH and HIST1H4A share multiple binding partners. One of these shared partners is described as binding at a stoichiometric ratio to the CENP-A/H4 tetramer ... | |
medium_convergence_07281 | MAPK1 and MAPK3 share a binding partner that is described as a protein variably expressed in multiple cell types, which blocks ERK-dependent transcription and proliferation by binding ERKs and preventing their nuclear localization. What molecular function is enabled by this shared entity? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_07281","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK1 and MAPK3 share a binding partner that is described as a protein variably expressed in multiple cell types, which blocks ERK-dependent transcription an... | |
medium_convergence_07282 | KRR1 and TRIM71 both interact with a specific shared protein. Evidence indicates that, compared to its paralog, this shared protein possesses a C-terminal unique ~50 amino acid stretch that is essential for its interaction with TRIM71 and subsequent polyubiquitination. Which protein is encoded by the gene corresponding... | Protein lin-28 homolog B | Medium | convergence | {"qa_id":"medium_convergence_07282","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRR1 and TRIM71 both interact with a specific shared protein. Evidence indicates that, compared to its paralog, this shared protein possesses a C-terminal un... | |
medium_convergence_07283 | PRDM14 and RUNX1 both interact with a shared gene product. Experimental evidence regarding this shared entity states: 'Immunoprecipitation analysis indicates that this region is required for AML1-MTG8 to form a stable complex with the shared entity.' Which cellular component is this shared entity located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_07283","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRDM14 and RUNX1 both interact with a shared gene product. Experimental evidence regarding this shared entity states: 'Immunoprecipitation analysis indicates... | |
medium_convergence_07284 | Both the positive regulation of type 2 immune response and interleukin-4 production are enabled by more than one cell type. One shared cell type is described as a mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses. Which cell type does this specific entity develop from? | activated CD4-negative, CD8-negative type I NK T cell | Medium | convergence | {"qa_id":"medium_convergence_07284","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the positive regulation of type 2 immune response and interleukin-4 production are enabled by more than one cell type. One shared cell type is described... | |
medium_convergence_07285 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (study GSE132081) shows a log2 fold change of approximately 1.52 and an adjusted p-value of 0.0167. Which biological process is this gene involved in? | negative regulation of fibroblast growth factor receptor signaling pathway | Medium | convergence | {"qa_id":"medium_convergence_07285","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (study GSE132081... | |
medium_convergence_07286 | PARP1 and ASF1A both interact with a specific gene product. Evidence indicates that newly synthesized histones H3-H4 first bind the histone chaperone Asf1 and are subsequently transferred to other chaperones for nucleosome assembly. Which protein is encoded by the gene product that fits this description? | Histone H3.3 | Medium | convergence | {"qa_id":"medium_convergence_07286","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and ASF1A both interact with a specific gene product. Evidence indicates that newly synthesized histones H3-H4 first bind the histone chaperone Asf1 an... | |
medium_convergence_07287 | Both Human alphaherpesvirus 1 and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene, derived from a monocytic leukemia cell line (study GSE114966), reports a log2 fold change of approximately -1.89 and an adjusted p-value of 0.0117. Which disease is associated with this... | schizoaffective disorder | Medium | convergence | {"qa_id":"medium_convergence_07287","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene, derived from a monocyt... | |
medium_convergence_07288 | Both CS and SIRT3 interact with multiple shared genes. One of these shared entities is directly deacetylated by SIRT3 at lysine 228 (K228). Which cell type is enriched for this specific entity? | memory B cell | Medium | convergence | {"qa_id":"medium_convergence_07288","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CS and SIRT3 interact with multiple shared genes. One of these shared entities is directly deacetylated by SIRT3 at lysine 228 (K228). Which cell type i... | |
medium_convergence_07290 | MAPT and MYC share common interacting partners. One such shared partner is characterized by evidence stating it binds to only one pT-P motif in tau and copurifies with paired helical filaments (PHFs). Which protein is encoded by this specific shared interacting partner? | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Medium | convergence | {"qa_id":"medium_convergence_07290","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPT and MYC share common interacting partners. One such shared partner is characterized by evidence stating it binds to only one pT-P motif in tau and copur... | |
medium_convergence_07291 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately 3.296 and an adjusted p-value of approximately 0.01255. Which protein is encoded by this gene? | Interleukin-11 | Medium | convergence | {"qa_id":"medium_convergence_07291","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (stud... | |
medium_convergence_07292 | BET1 and NAPA both interact with a specific protein. Experimental evidence indicates that both the NH2-terminal (residues 1-160) and COOH-terminal (residues 160-295) fragments of alpha-SNAP bind to this protein, suggesting that alpha-SNAP possesses distinct binding sites for it. Which protein product is encoded by this... | Vesicle-fusing ATPase | Medium | convergence | {"qa_id":"medium_convergence_07292","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BET1 and NAPA both interact with a specific protein. Experimental evidence indicates that both the NH2-terminal (residues 1-160) and COOH-terminal (residues ... | |
medium_convergence_07293 | INPP5D and CBL both interact with a shared protein. Evidence regarding this shared protein states: 'We also showed that [the protein encoded by INPPL1] was able to coimmunoprecipitate with endogenous c-Cbl protein in the absence of CAP and with the insulin receptor in CHO-IR cell extracts.' Which protein is encoded by ... | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | Medium | convergence | {"qa_id":"medium_convergence_07293","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"INPP5D and CBL both interact with a shared protein. Evidence regarding this shared protein states: 'We also showed that [the protein encoded by INPPL1] was a... | |
medium_convergence_07295 | DAXX and MYC both interact with a specific chromatin-associated protein. Experimental evidence using co-fractionation and co-immunoprecipitation demonstrates that this protein associates with factors critical for transcriptional repression, including histone deacetylase II, core histones (H2A, H2B, H3, and H4), and is ... | Protein DEK | Medium | convergence | {"qa_id":"medium_convergence_07295","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and MYC both interact with a specific chromatin-associated protein. Experimental evidence using co-fractionation and co-immunoprecipitation demonstrates... | |
medium_convergence_07296 | GDF7 and BMPR1B both interact with a common receptor. Evidence indicates this receptor is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which disease is causally linked to this specific receptor? | portal hypertension | Medium | convergence | {"qa_id":"medium_convergence_07296","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GDF7 and BMPR1B both interact with a common receptor. Evidence indicates this receptor is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 ... | |
medium_convergence_07298 | Cardiovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.218 and an adjusted p-value of 0.02872. Which protein is encoded by this gene? | N-acetylneuraminate lyase | Medium | convergence | {"qa_id":"medium_convergence_07298","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cardiovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967... | |
medium_convergence_07299 | EGFR and ERBB4 share interaction partners. One such partner is described by the following evidence: 'We observed that in co-transfected 293T cells, this protein forms a complex with each of the ErbB receptors independent of growth factor binding.' Which protein is encoded by this shared interaction partner? | Leucine-rich repeats and immunoglobulin-like domains protein 1 | Medium | convergence | {"qa_id":"medium_convergence_07299","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ERBB4 share interaction partners. One such partner is described by the following evidence: 'We observed that in co-transfected 293T cells, this prot... | |
medium_convergence_07300 | TP53 and VHL share multiple interacting partners. One such partner is reported to phosphorylate human p53 at Thr18 and disrupt the p53-Mdm2 interaction in vitro, although a significant decrease in p53 ubiquitination by Mdm2 in vivo was not detected. Which cell type is enriched for this specific interacting partner? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_07300","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TP53 and VHL share multiple interacting partners. One such partner is reported to phosphorylate human p53 at Thr18 and disrupt the p53-Mdm2 interaction in vi... | |
medium_convergence_07301 | PTP4A3 and TMPRSS11B both interact with a specific shared protein. Evidence indicates that this shared protein forms a functional heterodimer with PRL-2 to regulate intracellular magnesium levels. Which protein is encoded by this shared entity? | Metal transporter CNNM3 | Medium | convergence | {"qa_id":"medium_convergence_07301","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PTP4A3 and TMPRSS11B both interact with a specific shared protein. Evidence indicates that this shared protein forms a functional heterodimer with PRL-2 to r... | |
medium_convergence_07302 | CDK2 and PIN1 share a common interaction partner. Evidence indicates that this shared entity interacts with a nuclear receptor corepressor both in vitro and in mammalian cells, specifically noting the role of the peptidyl-prolyl isomerase Pin1. Which disease is associated with this shared entity via a biomarker relatio... | polyarticular arthritis | Medium | convergence | {"qa_id":"medium_convergence_07302","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and PIN1 share a common interaction partner. Evidence indicates that this shared entity interacts with a nuclear receptor corepressor both in vitro and ... | |
medium_convergence_07303 | The olfactory cortex layer 2 and the dorsal cochlear nucleus pyramidal cell layer are both classified as a specific type of anatomical structure. Evidence regarding one of these structures describes it as the middle layer of the olfactory cortex, located deep to layer 1 and superficial to layer 3, characterized by a co... | nervous system | Medium | convergence | {"qa_id":"medium_convergence_07303","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The olfactory cortex layer 2 and the dorsal cochlear nucleus pyramidal cell layer are both classified as a specific type of anatomical structure. Evidence re... | |
medium_convergence_07305 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -1.787 and an adjusted p-value of 0.01405. Which disease is associated with this gene through genomic alterations? | microcephaly | Medium | convergence | {"qa_id":"medium_convergence_07305","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study G... | |
medium_convergence_07307 | EYA4 and EYA2 both interact with a shared protein partner. Experimental evidence for this partner indicates that a specific interaction between its Six domain and homeodomain and EYA2 was observed via yeast two-hybrid analysis. Which protein is encoded by this shared partner? | Homeobox protein SIX4 | Medium | convergence | {"qa_id":"medium_convergence_07307","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EYA4 and EYA2 both interact with a shared protein partner. Experimental evidence for this partner indicates that a specific interaction between its Six domai... | |
medium_convergence_07308 | NEDD4 and YWHAH both interact with a shared gene product. Evidence indicates that the PY (Pro-Tyr) motif of this shared entity binds to the WW (Trp-Trp) domains of NEDD4. Which gene does this shared entity interact with? | RB1CC1 | Medium | convergence | {"qa_id":"medium_convergence_07308","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4 and YWHAH both interact with a shared gene product. Evidence indicates that the PY (Pro-Tyr) motif of this shared entity binds to the WW (Trp-Trp) doma... | |
medium_convergence_07309 | The biological processes 'regulation of branching involved in salivary gland morphogenesis' and 'regulation of branching involved in mammary gland duct morphogenesis' share a common parent process. Evidence for one such shared entity states: 'Any process that modulates the rate, frequency, or extent of branching morpho... | morphogenesis of an epithelium | Medium | convergence | {"qa_id":"medium_convergence_07309","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of branching involved in salivary gland morphogenesis' and 'regulation of branching involved in mammary gland duct morph... | |
medium_convergence_07310 | RSPO1 and RSPO2 both interact with a specific receptor protein. Experimental evidence indicates that in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, the binding affinities of RSPOs to the LRR1-14 domain of this receptor follow the order: RSPO4 > RSPO2 > RSPO3 > RSPO1. Which cellular component... | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_07310","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RSPO1 and RSPO2 both interact with a specific receptor protein. Experimental evidence indicates that in a time-resolved fluorescence resonance energy transfe... | |
medium_convergence_07311 | CHD4 and HDAC1 both interact with a shared protein. Evidence indicates that an affinity-purified HDAC1 corepressor complex contains this shared protein, suggesting that MeCP1 corresponds to a fraction of this complex. In which cell type is this shared protein enriched? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_07311","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and HDAC1 both interact with a shared protein. Evidence indicates that an affinity-purified HDAC1 corepressor complex contains this shared protein, sugg... | |
medium_convergence_07312 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.58 and an adjusted p-value of approximately 0.0409. Which protein is encoded by this gene? | Period circadian protein homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_07312","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (stud... | |
medium_convergence_07313 | NUP188 and NUP98 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here we show that this protein, the mammalian homologue of Gle2p, binds to a GLEBS-like motif at the NPC through multiple domains that include WD-repeats and a COOH-terminal non-WD-repeat exten... | mRNA export factor RAE1 | Medium | convergence | {"qa_id":"medium_convergence_07313","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUP188 and NUP98 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here we show that this protein... | |
medium_convergence_07314 | RAD51 and BRCA2 both interact with a shared protein partner. Evidence regarding one such partner states: 'Using the yeast two-hybrid system, we isolated a cDNA encoding a novel human protein, named [a RAD51-interacting protein], that strongly interacts with human Rad51 recombinase.' Which cell type is enriched in this ... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_07314","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51 and BRCA2 both interact with a shared protein partner. Evidence regarding one such partner states: 'Using the yeast two-hybrid system, we isolated a cD... | |
medium_convergence_07315 | CENPA and CENPW each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified this protein.' Which protein is encoded by that entity? | Holliday junction recognition protein | Medium | convergence | {"qa_id":"medium_convergence_07315","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPW each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosoma... | |
medium_convergence_07316 | Both Human alphaherpesvirus 1 and Human alphaherpesvirus 3 upregulate a specific gene. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene has a log2 fold change of approximately 2.42 and an adjusted p-value of approximately 0.012. What molecular function is enabled by this ... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_07316","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Human alphaherpesvirus 3 upregulate a specific gene. Experimental data from a monocytic leukemia cell line (study GSE114966... | |
medium_convergence_07317 | CAND1 and CUL3 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'The identified variant altered the localization pattern of this protein and abrogated interaction with cullin-3, a ubiquitin-ligase component and known interactor of this protein.' Which disease is ... | progressive myoclonic epilepsy type 3 | Medium | convergence | {"qa_id":"medium_convergence_07317","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL3 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'The identified variant altered the ... | |
medium_convergence_07318 | PARP1 and EZH2 share a common interacting partner. Experimental evidence indicates that this partner, along with Cenpa and Cenpb (but not Cenpc), interacts with PARP-1 and undergoes poly(ADP-ribosyl)ation following DNA damage. Which cellular component is this shared partner located in? | kinetochore | Medium | convergence | {"qa_id":"medium_convergence_07318","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and EZH2 share a common interacting partner. Experimental evidence indicates that this partner, along with Cenpa and Cenpb (but not Cenpc), interacts w... | |
medium_convergence_07319 | HEXIM1 and KMT2A both interact with a shared protein entity. Experimental evidence indicates that MAQ1 binds directly to the N-terminal cyclin homology region of cyclins T1 and T2. Which protein is encoded by the gene corresponding to this shared entity? | Cyclin-T1 | Medium | convergence | {"qa_id":"medium_convergence_07319","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HEXIM1 and KMT2A both interact with a shared protein entity. Experimental evidence indicates that MAQ1 binds directly to the N-terminal cyclin homology regio... | |
medium_convergence_07320 | GSK3B and FBXW7 share a common interaction partner. Evidence indicates that phosphorylation of cyclin E at threonine 380 by its associated CDK facilitates binding to Fbw7, the receptor subunit of the SCF(Fbw7) ubiquitin ligase. Which protein is connected to this shared entity through the 'encodes' relationship? | G1/S-specific cyclin-E1 | Medium | convergence | {"qa_id":"medium_convergence_07320","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GSK3B and FBXW7 share a common interaction partner. Evidence indicates that phosphorylation of cyclin E at threonine 380 by its associated CDK facilitates bi... | |
medium_convergence_07321 | Measles morbillivirus and Cardiovirus A both downregulate a specific gene. Experimental data for this gene reports a log2 fold change of -1.702 and an adjusted p-value of 0.0001111. In which cell type is this gene enriched? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_07321","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Cardiovirus A both downregulate a specific gene. Experimental data for this gene reports a log2 fold change of -1.702 and an adjust... | |
medium_convergence_07322 | Both CSF2RB and DMBT1 interact with a common protein partner. Evidence regarding this partner states: 'We have shown that soluble gp-340 binds the surfactant protein A family member in a calcium-dependent manner independent of the lectin activity of the surfactant protein A family member.' Which disease is associated w... | bronchiolitis | Medium | convergence | {"qa_id":"medium_convergence_07322","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CSF2RB and DMBT1 interact with a common protein partner. Evidence regarding this partner states: 'We have shown that soluble gp-340 binds the surfactant... | |
medium_convergence_07323 | DISC1 and MECP2 share common interacting partners. One such shared partner is functionally linked to repression through its in vivo association with human Brahma (Brm), a catalytic component of the SWI/SNF-related chromatin-remodeling complex. Which protein is encoded by this shared interacting partner? | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 | Medium | convergence | {"qa_id":"medium_convergence_07323","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DISC1 and MECP2 share common interacting partners. One such shared partner is functionally linked to repression through its in vivo association with human Br... | |
medium_convergence_07325 | COMMD1 and CUL1 both interact with a specific protein that functions as part of the SCF complex alongside Skp1 and Cullin1. This protein specifically interacts with phosphorylated IkappaB and beta-catenin, targeting them for proteasome-dependent degradation in vivo. Which protein is encoded by the gene corresponding to... | F-box/WD repeat-containing protein 11 | Medium | convergence | {"qa_id":"medium_convergence_07325","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL1 both interact with a specific protein that functions as part of the SCF complex alongside Skp1 and Cullin1. This protein specifically interac... | |
medium_convergence_07326 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.081 and an adjusted p-value of approximately 0.0237. Which cellular component is this gene located in? | extracellular exosome | Medium | convergence | {"qa_id":"medium_convergence_07326","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2... | |
medium_convergence_07327 | CPLX1 and PPFIA4 share common binding partners. One of these shared partners is described as binding in an antiparallel alpha-helical conformation to the groove between the synaptobrevin and syntaxin helices. Which disease is associated with this specific shared partner through genomic alterations? | oppositional defiant disorder | Medium | convergence | {"qa_id":"medium_convergence_07327","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CPLX1 and PPFIA4 share common binding partners. One of these shared partners is described as binding in an antiparallel alpha-helical conformation to the gro... | |
medium_convergence_07328 | ANAPC7 and ANAPC1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that a human protein also binds APC16 and APC7 and contains a >200-residue loop that is heavily phosphorylated during mitosis, although the basis for its interactions and whether loop phos... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_07328","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC7 and ANAPC1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that a human protein also... | |
medium_convergence_07329 | CHMP4B and CHMP6 both interact with a specific protein. Experimental evidence indicates that in a yeast two-hybrid assay, HD-PTP showed positive interactions with this protein (also known as Shax1), endophilin A1, and ALG-2, but not with RabGAPLP or CIN85. Which disease is associated with this protein? | microcephaly 29, primary, autosomal recessive | Medium | convergence | {"qa_id":"medium_convergence_07329","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and CHMP6 both interact with a specific protein. Experimental evidence indicates that in a yeast two-hybrid assay, HD-PTP showed positive interactions... | |
medium_convergence_07330 | EGFR and EPHA2 both interact with a specific shared protein. Evidence regarding this shared protein indicates that double and triple immunofluorescence, proximity ligation immunofluorescence, and co-immunoprecipitation studies revealed its association with KSHV-containing macropinosomes. Furthermore, increased levels o... | Tumor susceptibility gene 101 protein | Medium | convergence | {"qa_id":"medium_convergence_07330","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and EPHA2 both interact with a specific shared protein. Evidence regarding this shared protein indicates that double and triple immunofluorescence, prox... | |
medium_convergence_07331 | HSPA8 and HSP90AA1 both interact with a shared protein entity. Evidence regarding this entity states: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified as novel interaction partners while interaction with Hsc70 was confirmed.' Which protein is encoded by this shared entity? | Small glutamine-rich tetratricopeptide repeat-containing protein alpha | Medium | convergence | {"qa_id":"medium_convergence_07331","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA8 and HSP90AA1 both interact with a shared protein entity. Evidence regarding this entity states: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified ... | |
medium_convergence_07332 | MDM2 and PRKN share multiple interacting partners. One such partner is described in evidence stating that a specific protein interacts with both p53 and HDM2, inhibiting the auto-ubiquitination of HDM2 and thereby promoting p53 degradation. Which disease is associated with this specific shared partner via a biomarker r... | Lyme disease | Medium | convergence | {"qa_id":"medium_convergence_07332","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and PRKN share multiple interacting partners. One such partner is described in evidence stating that a specific protein interacts with both p53 and HDM2... | |
medium_convergence_07333 | CDT1 and CDC7 both interact with a specific protein component of the MCM complex. Evidence indicates that poly-ubiquitination of Geminin prevents DNA replication over-firing by indirectly blocking the association of Cdt1 with this MCM protein complex, an interaction required for DNA unwinding and replication. Which dis... | Meier-Gorlin syndrome | Medium | convergence | {"qa_id":"medium_convergence_07333","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDT1 and CDC7 both interact with a specific protein component of the MCM complex. Evidence indicates that poly-ubiquitination of Geminin prevents DNA replica... |
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