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medium_convergence_07334 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicate that this gene exhibits a log2 fold change of approximately 1.306 and an adjusted p-value of 0.03705. W... | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Medium | convergence | {"qa_id":"medium_convergence_07334","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental d... | |
medium_convergence_07335 | PARP1 and HIF1A share multiple interacting partners. One such partner is described as a small Maf protein that interacts directly with PARP-1, augmenting the ARE-specific DNA-binding of Nrf2 and enhancing the transcription of Nrf2 target genes. Which cell type is this specific partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_07335","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and HIF1A share multiple interacting partners. One such partner is described as a small Maf protein that interacts directly with PARP-1, augmenting the... | |
medium_convergence_07336 | SMAD4 and PRKN (PARK2) share common interacting partners. One such shared partner interacts with SMAD4, and evidence indicates that nuclear import of this complex requires structural elements present only in the full-length SMAD4. Which protein is encoded by the gene corresponding to this shared interacting partner? | Nuclear pore complex protein Nup214 | Medium | convergence | {"qa_id":"medium_convergence_07336","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD4 and PRKN (PARK2) share common interacting partners. One such shared partner interacts with SMAD4, and evidence indicates that nuclear import of this co... | |
medium_convergence_07337 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data for this gene in a study (GSE135619) reports a log2 fold change of approximately -2.017 and an adjusted p-value of approximately 0.0403. In which cell type is this... | memory B cell | Medium | convergence | {"qa_id":"medium_convergence_07337","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data ... | |
medium_convergence_07338 | TRAF2 and TRAF5 both interact with a specific shared protein. Evidence regarding this shared protein states: 'The intracellular domains of human and mouse [TNFRSF14] share only 25% identity, yet both interact with TRAF5 and TRAF2.' Which cellular component is this shared protein located in? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_07338","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRAF2 and TRAF5 both interact with a specific shared protein. Evidence regarding this shared protein states: 'The intracellular domains of human and mouse [T... | |
medium_convergence_07339 | Human alphaherpesvirus 1 and Pegivirus C both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.005 and an adjusted p-value of 0.002812. Which protein is encoded by this gene? | Cyclin-dependent kinase 4 inhibitor D | Medium | convergence | {"qa_id":"medium_convergence_07339","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Pegivirus C both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966)... | |
medium_convergence_07340 | COPS5 and MSH3 both interact with a shared protein. Evidence indicates that Jab1 physically associates with the 9-1-1 complex, and this association is mediated through a direct interaction between Jab1 and this shared protein, which is a subunit of the 9-1-1 complex. Which protein is encoded by the gene corresponding t... | Cell cycle checkpoint protein RAD1 | Medium | convergence | {"qa_id":"medium_convergence_07340","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and MSH3 both interact with a shared protein. Evidence indicates that Jab1 physically associates with the 9-1-1 complex, and this association is mediat... | |
medium_convergence_07341 | Both the regulation of glutamate secretion and the regulation of gamma-aminobutyric acid secretion are subtypes of a shared biological process. Evidence regarding one of these shared processes states: 'Any process that modulates the frequency, rate or extent of the controlled release of glutamate.' Which biological pro... | regulation of amine transport | Medium | convergence | {"qa_id":"medium_convergence_07341","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the regulation of glutamate secretion and the regulation of gamma-aminobutyric acid secretion are subtypes of a shared biological process. Evidence rega... | |
medium_convergence_07342 | MYB and MYC each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Here we show that, after stimulation with growth factor, this entity forms a complex with the dimer of MYC with MAX (Myc-associated factor X) via the MYC BoxII (MBII) domain.' Which gene is connected to that entity... | SND1 | Medium | convergence | {"qa_id":"medium_convergence_07342","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYB and MYC each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Here we show that, after stimulation with growth fa... | |
medium_convergence_07343 | DMD and AGRN share multiple binding partners. One such shared partner is described by the following evidence: 'Finally, we used in vitro translated proteins in an immunoprecipitation assay to show that, like beta 1-syntrophin, both beta 2- and alpha 1-syntrophin interact with peptides encoding the syntrophin-binding re... | CASK | Medium | convergence | {"qa_id":"medium_convergence_07343","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DMD and AGRN share multiple binding partners. One such shared partner is described by the following evidence: 'Finally, we used in vitro translated proteins ... | |
medium_convergence_07344 | CDK12 and EAF2 share multiple binding partners. One such partner is identified in an experiment where specific antibodies generated against EAF2 were used to co-immunoprecipitate this partner and EAF2 from multiple cell lines. Which disease is associated with this specific partner through genomic alterations? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_07344","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK12 and EAF2 share multiple binding partners. One such partner is identified in an experiment where specific antibodies generated against EAF2 were used to... | |
medium_convergence_07345 | NOD1 and MAP3K7 both interact with a specific shared protein. Evidence regarding this shared protein indicates that it forms a complex with TAK1 and TAB2, and also forms a complex with TAK1 and TAB3. Which protein is encoded by the gene corresponding to this shared entity? | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_07345","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NOD1 and MAP3K7 both interact with a specific shared protein. Evidence regarding this shared protein indicates that it forms a complex with TAK1 and TAB2, an... | |
medium_convergence_07347 | HSP90AA1 and MYH9 both interact with a specific shared protein. Evidence indicates that treatment with a peptide conjugated to the cell-permeating TAT(47-57) sequence increased the protein-protein interaction between this shared protein (specifically its epsilon isoform) and HSP90, enhanced the mitochondrial translocat... | Protein kinase C epsilon type | Medium | convergence | {"qa_id":"medium_convergence_07347","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and MYH9 both interact with a specific shared protein. Evidence indicates that treatment with a peptide conjugated to the cell-permeating TAT(47-57)... | |
medium_convergence_07348 | PRKN and SRC share multiple interacting partners. One such partner is described in mechanistic studies as a specific nuclear receptor, which acts as a critical inhibitory regulator in inflammatory bowel disease (IBD). Which protein is encoded by this specific shared interacting partner? | Vitamin D3 receptor | Medium | convergence | {"qa_id":"medium_convergence_07348","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and SRC share multiple interacting partners. One such partner is described in mechanistic studies as a specific nuclear receptor, which acts as a critic... | |
medium_convergence_07349 | ARNT and ELOC each interact with more than one shared protein partner. Evidence concerning one such shared entity reports that immunoprecipitation and in vitro binding experiments suggest CK1-dependent phosphorylation of a hypoxia-inducible factor alpha subunit at Ser247 impairs its association with this entity, a noti... | Hypoxia-inducible factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_07349","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARNT and ELOC each interact with more than one shared protein partner. Evidence concerning one such shared entity reports that immunoprecipitation and in vit... | |
medium_convergence_07350 | FGF1 and FGF23 share common binding partners. One such partner is described by evidence stating: 'In solution, the protein formed complexes with acidic FGF (FGF-1) and basic FGF (FGF-2), both in the presence and absence of heparin.' Which protein is encoded by the gene corresponding to this interaction partner? | Fibroblast growth factor receptor 4 | Medium | convergence | {"qa_id":"medium_convergence_07350","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF1 and FGF23 share common binding partners. One such partner is described by evidence stating: 'In solution, the protein formed complexes with acidic FGF (... | |
medium_convergence_07351 | FGF1 and FGF9 both interact with a specific receptor. Experimental evidence indicates that this receptor forms complexes with acidic FGF (FGF-1) and basic FGF (FGF-2) in solution, regardless of heparin presence. Which disease is associated with this receptor as a biomarker? | cholangiocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_07351","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF1 and FGF9 both interact with a specific receptor. Experimental evidence indicates that this receptor forms complexes with acidic FGF (FGF-1) and basic FG... | |
medium_convergence_07352 | CBX3 and FANCD2 share a common interaction partner. Evidence indicates that this shared partner forms a direct protein-protein interaction with UHRF2. Which disease is associated with this shared partner through genomic alterations? | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_07352","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and FANCD2 share a common interaction partner. Evidence indicates that this shared partner forms a direct protein-protein interaction with UHRF2. Which ... | |
medium_convergence_07353 | PRKDC and RXRA both interact with a shared protein. Evidence regarding this shared protein states: 'The auxiliary factor is identical to the retinoid X receptor alpha (RXR alpha) by biochemical and functional criteria.' Which protein is encoded by this shared entity? | Thyroid hormone receptor alpha | Medium | convergence | {"qa_id":"medium_convergence_07353","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKDC and RXRA both interact with a shared protein. Evidence regarding this shared protein states: 'The auxiliary factor is identical to the retinoid X recep... | |
medium_convergence_07354 | EGFR and NEDD4 share a common interacting partner. Evidence for this interaction states: 'In support of the possibility that this may be a direct interaction, we show that the two receptors can be coimmunoprecipitated from untransfected Hs27 fibroblasts and from COS-7 cells.' Which protein is encoded by the gene corres... | Platelet-derived growth factor receptor beta | Medium | convergence | {"qa_id":"medium_convergence_07354","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and NEDD4 share a common interacting partner. Evidence for this interaction states: 'In support of the possibility that this may be a direct interaction... | |
medium_convergence_07355 | Diclofenac (ophthalmic) and Clofarabine share a common interacting drug. Clinical evidence describes a case of a 46-year-old woman who experienced acute renal and hepatic injury and myalgia after two years of concomitant treatment with diclofenac, atorvastatin, simvastatin, the shared drug, and several other medication... | inherited lipid metabolism disorder | Medium | convergence | {"qa_id":"medium_convergence_07355","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Diclofenac (ophthalmic) and Clofarabine share a common interacting drug. Clinical evidence describes a case of a 46-year-old woman who experienced acute rena... | |
medium_convergence_07356 | Pegaspargase and Imatinib both interact with a specific shared drug. Evidence indicates that this shared drug exhibited the strongest inhibitory effect towards CYP3A, whereas the inhibitory potential of gefitinib and sunitinib was comparable to each other but weaker than that of the shared drug. Which disease is this s... | hypogonadotropic hypogonadism | Medium | convergence | {"qa_id":"medium_convergence_07356","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Pegaspargase and Imatinib both interact with a specific shared drug. Evidence indicates that this shared drug exhibited the strongest inhibitory effect towar... | |
medium_convergence_07358 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately -1.62 and an adjusted p-value of approximately 0.0024. Which protein does this gene interact with? | RAC1 | Medium | convergence | {"qa_id":"medium_convergence_07358","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) ind... | |
medium_convergence_07359 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. In a study involving lung fibroblast cell lines (GSE120891), this gene exhibited a log2 fold change of approximately 1.27 and an adjusted p-value of approximately 0.046. Which p... | Oxidative stress-responsive serine-rich protein 1 | Medium | convergence | {"qa_id":"medium_convergence_07359","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. In a study inv... | |
medium_convergence_07360 | GNB2 and GNB4 both interact with a shared protein partner. Experimental evidence indicates that this partner forms stable dimers with Gbeta4, and these dimers are capable of stimulating phospholipase beta2. Which protein is encoded by the gene corresponding to this shared partner? | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | Medium | convergence | {"qa_id":"medium_convergence_07360","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNB2 and GNB4 both interact with a shared protein partner. Experimental evidence indicates that this partner forms stable dimers with Gbeta4, and these dimer... | |
medium_convergence_07361 | GATA1 and HIST1H4A share common binding partners. One such partner is implicated in a study describing the solution NMR structure of a specific protein domain in complex with a H4K16ac peptide, which reveals mechanistic features underlying the recognition of H4K16ac. Which protein encodes the enzyme corresponding to th... | Histone-lysine N-methyltransferase 2D | Medium | convergence | {"qa_id":"medium_convergence_07361","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA1 and HIST1H4A share common binding partners. One such partner is implicated in a study describing the solution NMR structure of a specific protein domai... | |
medium_convergence_07362 | ZMYND8 and RBPJ share multiple interacting partners. One specific shared partner is known to physically interact with RBP-J, an interaction that is conserved in Drosophila and plays a crucial role in Notch-induced growth and tumorigenesis responses. Which cell type is this specific shared partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_07362","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ZMYND8 and RBPJ share multiple interacting partners. One specific shared partner is known to physically interact with RBP-J, an interaction that is conserved... | |
medium_convergence_07364 | STUB1 and EGFR both interact with a shared protein. Evidence indicates that the interaction between CHIP and this shared protein is mediated by Hsp70, which binds to the tetratricopeptide repeat domain of CHIP and the BAG domains of the shared protein. Which protein is encoded by this shared gene? | BAG family molecular chaperone regulator 5 | Medium | convergence | {"qa_id":"medium_convergence_07364","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and EGFR both interact with a shared protein. Evidence indicates that the interaction between CHIP and this shared protein is mediated by Hsp70, which ... | |
medium_convergence_07365 | Both Human respirovirus 3 and Human immunodeficiency virus 1 are reported to upregulate a specific gene. Experimental data from a non-small cell lung adenocarcinoma cell line (study GSE147507) indicates that this shared target has a log2 fold change of approximately 1.012 and an adjusted p-value of 0.04933. Which prote... | B-cell lymphoma 3 protein | Medium | convergence | {"qa_id":"medium_convergence_07365","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Human immunodeficiency virus 1 are reported to upregulate a specific gene. Experimental data from a non-small cell lung adenoca... | |
medium_convergence_07366 | ID2 and ASCL3 both interact with a specific transcription factor. Evidence regarding this shared partner states: 'All three Ids bound with high affinity to E proteins, but a much broader range of interactions was observed between Ids and the class B factors.' Which protein is encoded by this shared transcription factor... | Transcription factor E2-alpha | Medium | convergence | {"qa_id":"medium_convergence_07366","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ID2 and ASCL3 both interact with a specific transcription factor. Evidence regarding this shared partner states: 'All three Ids bound with high affinity to E... | |
medium_convergence_07367 | F8 and GOLGA2 each share a binding partner. Evidence concerning one such shared entity indicates that a Golgi reassembly-stacking protein exists in a complex with the vesicle docking protein receptor GM130, to which it binds directly, and with the membrane tethering protein p115, which also functions in the stacking of... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_07367","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"F8 and GOLGA2 each share a binding partner. Evidence concerning one such shared entity indicates that a Golgi reassembly-stacking protein exists in a complex... | |
medium_convergence_07368 | Both INHBA and INHBB interact with a shared receptor. Evidence regarding one such shared entity states: 'We hypothesized that, in addition to its canonical receptor [receptor], activin A might similarly bind and signal via BMPR2.' Which disease is associated with this specific entity through genomic alterations? | malignant colon neoplasm | Medium | convergence | {"qa_id":"medium_convergence_07368","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both INHBA and INHBB interact with a shared receptor. Evidence regarding one such shared entity states: 'We hypothesized that, in addition to its canonical r... | |
medium_convergence_07369 | BRD4 and HIST1H1A share multiple interacting partners. One such shared partner is specifically associated with histone H1 in mammalian somatic cell nuclei, distinguishing it from other core or linker histone chaperone candidates. Which disease is linked to this specific shared partner via a biomarker relationship? | triploidy | Medium | convergence | {"qa_id":"medium_convergence_07369","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and HIST1H1A share multiple interacting partners. One such shared partner is specifically associated with histone H1 in mammalian somatic cell nuclei, d... | |
medium_convergence_07370 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line study (GSE11238) indicates that this gene has a log2 fold change of approximately -1.53 and an adjusted p-value of approximately 0.0037. Which disease is associated with this gene? | chromosome 4 short arm deletion | Medium | convergence | {"qa_id":"medium_convergence_07370","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line study (GSE11238) ind... | |
medium_convergence_07371 | RBPMS and PRKN (Parkin) share interaction partners. One such shared partner is described in the following context: 'Here, we investigate the role of the endosomal adaptor [Entity] during the mitochondrial stress response and identify its interaction and colocalisation with the Parkinson's disease-associated E3 ubiquiti... | Toll-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_07371","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBPMS and PRKN (Parkin) share interaction partners. One such shared partner is described in the following context: 'Here, we investigate the role of the endo... | |
medium_convergence_07372 | EP300 and ESR1 share multiple interacting partners. One such shared partner forms a ternary complex with CARM1 and p300/CBP in cultured mammalian cells, a finding that supports a physiological role for the observed synergy. Which protein is encoded by this shared interacting partner? | Glutamate receptor-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_07372","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and ESR1 share multiple interacting partners. One such shared partner forms a ternary complex with CARM1 and p300/CBP in cultured mammalian cells, a fi... | |
medium_convergence_07373 | CSNK2B and MAPK1 both interact with a shared protein. Evidence regarding this shared protein states: 'These two kinases were found to be associated in unstimulated PMN but dissociated upon activation of the cells by fMLP.' Which cell type is this shared protein enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_07373","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and MAPK1 both interact with a shared protein. Evidence regarding this shared protein states: 'These two kinases were found to be associated in unstim... | |
medium_convergence_07374 | IRAK1 and MAP3K3 both interact with a shared protein. Evidence regarding one such shared partner states: 'Interestingly, we also find that a kinase and MEKK3 form a functional complex, in which the kinase regulates autophosphorylation of MEKK3.' Which disease is associated with this specific shared protein through geno... | cardiospondylocarpofacial syndrome | Medium | convergence | {"qa_id":"medium_convergence_07374","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRAK1 and MAP3K3 both interact with a shared protein. Evidence regarding one such shared partner states: 'Interestingly, we also find that a kinase and MEKK3... | |
medium_convergence_07375 | Peginterferon alfa-2b and Cyclosporine both interact with a specific drug. Evidence regarding this drug states: 'These effects of cyclosporine and gemfibrozil explain the increased plasma statin concentrations and, together with pharmacodynamic factors, the increased risk of myotoxicity when coadministered with statins... | Familial type 3 hyperlipoproteinemia | Medium | convergence | {"qa_id":"medium_convergence_07375","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Peginterferon alfa-2b and Cyclosporine both interact with a specific drug. Evidence regarding this drug states: 'These effects of cyclosporine and gemfibrozi... | |
medium_convergence_07376 | DCTN1 and COPZ1 both interact with a shared protein partner. Evidence regarding this partner states: 'Phosphorylation also enhanced the specific binding of p150(Glued) to the tail domain of HsEg5 in vitro, indicating that the two proteins are able to interact directly.' Which gene encodes this shared protein partner? | Kinesin-like protein KIF11 | Medium | convergence | {"qa_id":"medium_convergence_07376","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCTN1 and COPZ1 both interact with a shared protein partner. Evidence regarding this partner states: 'Phosphorylation also enhanced the specific binding of p... | |
medium_convergence_07378 | GP1BA and GP5 both interact with a common protein partner. Structural evidence describes the complex formed between the GpIbalpha amino-terminal domain and the A1 domain of this shared partner. Which protein is encoded by the gene corresponding to this shared partner? | von Willebrand factor | Medium | convergence | {"qa_id":"medium_convergence_07378","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GP1BA and GP5 both interact with a common protein partner. Structural evidence describes the complex formed between the GpIbalpha amino-terminal domain and t... | |
medium_convergence_07380 | Hydrocortisone and Dexamethasone both interact with a specific drug. Evidence regarding this drug notes that while systemic steroids are commonly used to manage immune-related adverse events (irAEs), it remains unclear whether they may undermine immune checkpoint inhibitor (ICI) therapy outcomes. Which disease is this ... | colorectal cancer | Medium | convergence | {"qa_id":"medium_convergence_07380","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hydrocortisone and Dexamethasone both interact with a specific drug. Evidence regarding this drug notes that while systemic steroids are commonly used to man... | |
medium_convergence_07382 | COPA and CAPZA3 both interact with a shared protein partner. Evidence for one such partner includes immunoprecipitation and two-hybrid system analysis from a complete COP screen, which demonstrated physical interactions between alpha- and epsilon-COPs and between beta- and delta-COPs. Which biological process is this s... | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | Medium | convergence | {"qa_id":"medium_convergence_07382","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPA and CAPZA3 both interact with a shared protein partner. Evidence for one such partner includes immunoprecipitation and two-hybrid system analysis from a... | |
medium_convergence_07383 | CSNK2A2 and RNF2 both interact with a shared protein partner. Biochemical evidence indicates that this partner (or its homolog) associates with PCGF-RING1A/B combinations to form complexes that prevent the incorporation of canonical PRC1 subunits such as CBX, PHC, and SCM. Which protein is encoded by the gene correspon... | RING1 and YY1-binding protein | Medium | convergence | {"qa_id":"medium_convergence_07383","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A2 and RNF2 both interact with a shared protein partner. Biochemical evidence indicates that this partner (or its homolog) associates with PCGF-RING1A/B... | |
medium_convergence_07385 | SMAD2 and SMAD3 share a common interacting partner. Evidence indicates that this partner interacts with both SMAD2 and SMAD3, but not with SMAD4, and that this interaction is enhanced by the phosphorylation of (S/T)P motifs in the Smad linker region. Which disease is associated with this interacting partner as a biomar... | malignant pancreatic neoplasm | Medium | convergence | {"qa_id":"medium_convergence_07385","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD2 and SMAD3 share a common interacting partner. Evidence indicates that this partner interacts with both SMAD2 and SMAD3, but not with SMAD4, and that th... | |
medium_convergence_07386 | RAD51AP1 and PHLPP1 both interact with a specific deubiquitinating enzyme. Experimental evidence indicates that this enzyme binds to PHLPP and directly removes polyubiquitin chains from PHLPP in vitro and in cells. Which protein is encoded by the gene corresponding to this enzyme? | Ubiquitin carboxyl-terminal hydrolase 46 | Medium | convergence | {"qa_id":"medium_convergence_07386","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51AP1 and PHLPP1 both interact with a specific deubiquitinating enzyme. Experimental evidence indicates that this enzyme binds to PHLPP and directly remov... | |
medium_convergence_07387 | ERBB2 and HDAC1 both interact with a shared protein. Evidence regarding one such shared partner states: 'We found no evidence that ATP operates by phosphorylation of components of the HDAC complex, but have shown that HDACs 1, 2, and 3 all co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70.' Which cell... | naive B cell | Medium | convergence | {"qa_id":"medium_convergence_07387","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and HDAC1 both interact with a shared protein. Evidence regarding one such shared partner states: 'We found no evidence that ATP operates by phosphoryl... | |
medium_convergence_07388 | ARHGEF18 and CDC42 both interact with a specific protein. Evidence indicates that this protein forms a complex with Cdc42-GTP, a human homologue of the multi-PDZ protein PAR-3, and the regulatory domains of atypical protein kinase C (PKC) proteins. Which protein is encoded by the gene corresponding to this interacting ... | Partitioning defective 6 homolog alpha | Medium | convergence | {"qa_id":"medium_convergence_07388","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARHGEF18 and CDC42 both interact with a specific protein. Evidence indicates that this protein forms a complex with Cdc42-GTP, a human homologue of the multi... | |
medium_convergence_07389 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific shared gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 2.356 and an adjusted p-value of 0.02937. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_07389","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific shared gene. Experimental data for this gene in a monocytic leukemia cell lin... | |
medium_convergence_07390 | ESR1 and AR share multiple interacting partners. One such shared partner is implicated in the regulation of HOXA10, where its knockdown suppresses HOXA10 activation and it binds to the HOXA10 promoter's estrogen response element in an estrogen-dependent manner by forming a complex with ERα. Which cell type is this spec... | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_07390","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and AR share multiple interacting partners. One such shared partner is implicated in the regulation of HOXA10, where its knockdown suppresses HOXA10 act... | |
medium_convergence_07391 | YAP1 and EP300 share multiple interacting partners. One such partner is described in evidence stating: 'Coexpression of CREB-binding protein (CBP)/p300 with a specific interacting partner has an additive effect on promoter activity, and the proteins were demonstrated to interact physically.' Which disease is associated... | refractory malignant neoplasm | Medium | convergence | {"qa_id":"medium_convergence_07391","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and EP300 share multiple interacting partners. One such partner is described in evidence stating: 'Coexpression of CREB-binding protein (CBP)/p300 with ... | |
medium_convergence_07392 | FGF10 and BMP7 are both involved in a shared biological process. Evidence indicates that FGF-10 positive cells appeared in all metanephric structures during the 5th week of development, and that cell survival and nephrogenesis in the permanent kidney are associated with the appearance of both growth factors. Which anat... | metanephros | Medium | convergence | {"qa_id":"medium_convergence_07392","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF10 and BMP7 are both involved in a shared biological process. Evidence indicates that FGF-10 positive cells appeared in all metanephric structures during ... | |
medium_convergence_07393 | DCTN1 and MYC both interact with a shared gene. Evidence indicates that upregulation of this shared entity increases its binding with c-Myc and activates c-Myc, which in turn induces the expression of CCND1/CDK4, promoting glioma cell temozolomide resistance and proliferation. Which cell type is this shared entity enri... | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_07393","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCTN1 and MYC both interact with a shared gene. Evidence indicates that upregulation of this shared entity increases its binding with c-Myc and activates c-M... | |
medium_convergence_07394 | DCUN1D1 and CUL1 share multiple binding partners. One such partner is characterized by proteomic analysis demonstrating interactions with Skp1, Cullin1, Ring-box1, and all components of the COP9 signalosome. Which cellular component is this specific partner located in? | ubiquitin ligase complex | Medium | convergence | {"qa_id":"medium_convergence_07394","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCUN1D1 and CUL1 share multiple binding partners. One such partner is characterized by proteomic analysis demonstrating interactions with Skp1, Cullin1, Ring... | |
medium_convergence_07395 | EP300 and SIRT1 share multiple interacting partners. One such partner is described by evidence stating: 'Furthermore, mammalian two-hybrid and immunoprecipitation studies revealed the transactivation domain of HNF-1alpha (amino acids 391-540) to interact with both the NH(2)-terminal region (amino acids 180-662) and the... | Hepatocyte nuclear factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_07395","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and SIRT1 share multiple interacting partners. One such partner is described by evidence stating: 'Furthermore, mammalian two-hybrid and immunoprecipit... | |
medium_convergence_07396 | POLA1 and POLE2 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'We have identified a short conserved motif at the extreme C terminus of pol α that is critical for interaction of the yeast ortholog pol1 with primase.' Which disease is connected to that entity through an asso... | primordial dwarfism-immunodeficiency-lipodystrophy syndrome | Medium | convergence | {"qa_id":"medium_convergence_07396","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLA1 and POLE2 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'We have identified a short conserved motif at t... | |
medium_convergence_07397 | Amikacin and Neomycin both interact with a specific drug. Evidence indicates that this drug enhances the bacteriostatic and bactericidal activity of these two aminoglycosides against most gram-negative bacilli, although bactericidal activity was significantly diminished in 4 of 65 strains. Which drug does this entity i... | Picosulfuric acid | Medium | convergence | {"qa_id":"medium_convergence_07397","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Amikacin and Neomycin both interact with a specific drug. Evidence indicates that this drug enhances the bacteriostatic and bactericidal activity of these tw... | |
medium_convergence_07399 | BLM and FAAP100 share multiple binding partners. One such shared partner is described in the following evidence: 'Here, we show that this protein forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF.' Which protein is encoded by this shared partner? | Fanconi anemia group M protein | Medium | convergence | {"qa_id":"medium_convergence_07399","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BLM and FAAP100 share multiple binding partners. One such shared partner is described in the following evidence: 'Here, we show that this protein forms a con... | |
medium_convergence_07400 | CCL3 and CCL5 both interact with a specific G-protein coupled receptor. Experimental evidence indicates that RANTES (CCL5) associates with this receptor, as well as with syndecan-1, syndecan-4, CD44, and CCR1, but does not associate with syndecan-2 or betaglycan. Which protein is encoded by the gene corresponding to th... | C-C chemokine receptor type 5 | Medium | convergence | {"qa_id":"medium_convergence_07400","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCL3 and CCL5 both interact with a specific G-protein coupled receptor. Experimental evidence indicates that RANTES (CCL5) associates with this receptor, as ... | |
medium_convergence_07401 | BMP10 and MYH6 are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that Morpholino knock-down of the chick homolog of MYH6 eliminates the formation of the atrial septum without overtly affecting atrial chamber formation. Which anatomical structure is... | cardiac muscle tissue of atrium | Medium | convergence | {"qa_id":"medium_convergence_07401","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP10 and MYH6 are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that Morpholino knoc... | |
medium_convergence_07402 | NEDD4L and TSG101 both interact with a specific shared protein. Evidence regarding this shared protein states: 'The ability of HCRP1 (which we assign the alternative name hVps37A) to interact with Tsg101 is conferred by its mod(r) domain and is shared with hVps37B and hVps37C, two other mod(r) domain-containing protein... | HGS | Medium | convergence | {"qa_id":"medium_convergence_07402","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and TSG101 both interact with a specific shared protein. Evidence regarding this shared protein states: 'The ability of HCRP1 (which we assign the alt... | |
medium_convergence_07403 | UBQLN2 and MAPT share multiple interacting partners. One such partner is involved in a specific interaction with Tau: while cytosolic Tau normally interacts only weakly with this partner, mutations that mimic abnormal phosphorylation promote this interaction. Which protein is encoded by this specific interacting partne... | Cytotoxic granule associated RNA binding protein TIA1 | Medium | convergence | {"qa_id":"medium_convergence_07403","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBQLN2 and MAPT share multiple interacting partners. One such partner is involved in a specific interaction with Tau: while cytosolic Tau normally interacts ... | |
medium_convergence_07404 | OTUD3 and HDAC1 both interact with a specific shared protein. Evidence indicates that this shared protein forms a ternary complex in vivo with p65/RelA and HDAC1. Which protein is encoded by the gene corresponding to this shared entity? | Peroxisome proliferator-activated receptor delta | Medium | convergence | {"qa_id":"medium_convergence_07404","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OTUD3 and HDAC1 both interact with a specific shared protein. Evidence indicates that this shared protein forms a ternary complex in vivo with p65/RelA and H... | |
medium_convergence_07405 | The sacral vertebra endochondral element and the caudal vertebra endochondral element share a common anatomical classification. Evidence regarding one such shared entity describes it as a vertebra endochondral element that is part of the sacral region of the vertebral column. What is the broader anatomical category to ... | skeletal element | Medium | convergence | {"qa_id":"medium_convergence_07405","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The sacral vertebra endochondral element and the caudal vertebra endochondral element share a common anatomical classification. Evidence regarding one such s... | |
medium_convergence_07406 | Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of approximately -1.044 and an adjusted p-value of 0.02825. Which biological process is this gene involved in? | protein autoubiquitination | Medium | convergence | {"qa_id":"medium_convergence_07406","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) sh... | |
medium_convergence_07407 | GNB1 and GNB4 both interact with a specific shared protein partner. Evidence regarding this partner states: 'The gamma 10 is modified by a geranylgeranyl group and is capable of interacting with beta 1 and beta 2 but not with beta 3.' Which protein is encoded by the gene corresponding to this shared partner? | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | Medium | convergence | {"qa_id":"medium_convergence_07407","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNB1 and GNB4 both interact with a specific shared protein partner. Evidence regarding this partner states: 'The gamma 10 is modified by a geranylgeranyl gro... | |
medium_convergence_07409 | The biological processes 'regulation of branching involved in salivary gland morphogenesis' and 'regulation of branching involved in lung morphogenesis' share a common parent process. Evidence for one such shared entity states: 'Any process that modulates the rate, frequency, or extent of branching morphogenesis in the... | morphogenesis of a branching structure | Medium | convergence | {"qa_id":"medium_convergence_07409","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of branching involved in salivary gland morphogenesis' and 'regulation of branching involved in lung morphogenesis' shar... | |
medium_convergence_07411 | SIN3A and HDAC2 each interact with more than one shared protein. Evidence concerning one such shared entity reports: 'Here, we reveal that this protein interacts with histone methyltransferase (PRC2) and histone deacetylase (NuRD and SIN3A) complexes through their common subunit, RBBP4/7.' Which protein is connected to... | BCL11 transcription factor A | Medium | convergence | {"qa_id":"medium_convergence_07411","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and HDAC2 each interact with more than one shared protein. Evidence concerning one such shared entity reports: 'Here, we reveal that this protein inter... | |
medium_convergence_07412 | LAMTOR2 and ATP6V1F each interact with more than one shared protein. Evidence concerning one of these shared entities describes it as an uncharacterized protein with sequence similarity to amino acid transporters, functioning as a lysosomal transmembrane protein that interacts with the Rag guanosine triphosphatases (GT... | Neutral amino acid transporter 9 | Medium | convergence | {"qa_id":"medium_convergence_07412","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR2 and ATP6V1F each interact with more than one shared protein. Evidence concerning one of these shared entities describes it as an uncharacterized prot... | |
medium_convergence_07413 | Both ABL1 and ABL2 interact with a specific shared protein. Experimental evidence indicates that hydrogen peroxide (H2O2) induces the binding of c-Abl and Arg to this shared entity, which is identified as the enzyme encoded by the CAT gene. Which cell type is enriched for this entity? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_07413","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ABL1 and ABL2 interact with a specific shared protein. Experimental evidence indicates that hydrogen peroxide (H2O2) induces the binding of c-Abl and Ar... | |
medium_convergence_07414 | Hydrocortisone and Prednisolone both interact with a specific drug. Evidence regarding this drug notes that while systemic steroids are commonly used to manage immune-related adverse events (irAEs), it remains unclear whether they may undermine immune checkpoint inhibitor (ICI) therapy outcomes. Which disease is this d... | colorectal cancer | Medium | convergence | {"qa_id":"medium_convergence_07414","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hydrocortisone and Prednisolone both interact with a specific drug. Evidence regarding this drug notes that while systemic steroids are commonly used to mana... | |
medium_convergence_07415 | Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Evidence for this gene in a study (GSE135833) reports a log2 fold change of approximately 3.13 and an adjusted p-value of approximately 0.023. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_07415","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Evidence for this gene in a study (GSE135833) reports a log2 fold change of approxima... | |
medium_convergence_07416 | COMMD1 and CUL2 both interact with a specific protein. Evidence indicates that this protein, along with another protein sharing a region of homology with VHL (specifically the VHL box, including the BC box and downstream residues) and associating with the CUL2-Rbx1 complex, is the target of interest. Which biological p... | negative regulation of DNA-templated DNA replication | Medium | convergence | {"qa_id":"medium_convergence_07416","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL2 both interact with a specific protein. Evidence indicates that this protein, along with another protein sharing a region of homology with VHL... | |
medium_convergence_07417 | GRIK1 and GRIN1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Immunoprecipitation experiments with an anti-NR1 antibody demonstrated that the majority of NR3A is associated with NR1 in postnatal day 10 rat cortex (80 +/- 8%), decreasing by half (38 +/- 4%)... | Glutamate receptor ionotropic, NMDA 3A | Medium | convergence | {"qa_id":"medium_convergence_07417","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRIK1 and GRIN1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Immunoprecipitation experiments... | |
medium_convergence_07418 | XRCC6 and MYC share multiple interacting partners. One such shared partner is implicated in evidence stating that Ku proteins were identified as a transcription factor interacting protein via GST-pull down followed by mass spectrometry. Which protein encodes the entity described in this evidence? | Transcription factor AP-2-alpha | Medium | convergence | {"qa_id":"medium_convergence_07418","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and MYC share multiple interacting partners. One such shared partner is implicated in evidence stating that Ku proteins were identified as a transcript... | |
medium_convergence_07419 | EP300 and PYGO2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'A monoclonal antibody raised against the carboxyl terminus of this protein coimmunoprecipitates CBP/p300, supporting the model that this protein is a CBP binding protein and that these proteins can be found ... | developmental delay, hypotonia, musculoskeletal defects, and behavioral abnormalities | Medium | convergence | {"qa_id":"medium_convergence_07419","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and PYGO2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'A monoclonal antibody raised against the car... | |
medium_convergence_07420 | MYB and RBBP7 both interact with a specific protein. Evidence regarding this protein states: 'Here we report that [the protein] directly binds to the NRD and negatively regulates the c-Myb-dependent trans-activation.' Which protein is encoded by the gene corresponding to this shared interaction partner? | Transcription intermediary factor 1-beta | Medium | convergence | {"qa_id":"medium_convergence_07420","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYB and RBBP7 both interact with a specific protein. Evidence regarding this protein states: 'Here we report that [the protein] directly binds to the NRD and... | |
medium_convergence_07421 | GRIN2B and HSPA5 share multiple interacting partners. One such shared partner is physically associated with phosphorylated NMDAR2B, a finding supported by co-immunoprecipitation, confocal immunofluorescence, and proximity ligation assays. Which protein is encoded by this shared partner? | Hepatocyte growth factor receptor | Medium | convergence | {"qa_id":"medium_convergence_07421","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRIN2B and HSPA5 share multiple interacting partners. One such shared partner is physically associated with phosphorylated NMDAR2B, a finding supported by co... | |
medium_convergence_07422 | COPS5 and FHL2 both interact with a specific gene product. Evidence regarding this shared entity states: 'Here we have identified a protein that interacts with the cytoplasmic domain of the beta2 subunit of the alphaL/beta2 integrin [shared entity].' Which protein is encoded by this shared gene? | Integrin beta-2 | Medium | convergence | {"qa_id":"medium_convergence_07422","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and FHL2 both interact with a specific gene product. Evidence regarding this shared entity states: 'Here we have identified a protein that interacts wi... | |
medium_convergence_07423 | KAT5 and HERC2 both interact with a common protein partner. Evidence indicates that in response to ionizing radiation, this shared partner forms a complex with HERC2 and functions as a ubiquitin ligase involved in the DNA damage response. Which protein is encoded by this shared partner? | E3 ubiquitin-protein ligase RNF8 | Medium | convergence | {"qa_id":"medium_convergence_07423","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and HERC2 both interact with a common protein partner. Evidence indicates that in response to ionizing radiation, this shared partner forms a complex wi... | |
medium_convergence_07424 | NEDD4 and RALGDS both interact with a shared protein. Evidence indicates that CNrasGEF possesses two PY motifs at its C-terminus responsible for binding to this shared protein in vitro. Which protein is encoded by the gene corresponding to this shared protein? | Rap guanine nucleotide exchange factor 2 | Medium | convergence | {"qa_id":"medium_convergence_07424","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4 and RALGDS both interact with a shared protein. Evidence indicates that CNrasGEF possesses two PY motifs at its C-terminus responsible for binding to t... | |
medium_convergence_07425 | AP2B1 and EPS15 both interact with a specific gene product. Contextual evidence indicates that this gene product, along with FCHo2 and SGIP1, acts as a key regulator of clathrin-mediated endocytosis. Specifically, the mu homology domains of these regulators interact with the C-terminal region of an endocytic scaffold p... | PCGF1 | Medium | convergence | {"qa_id":"medium_convergence_07425","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2B1 and EPS15 both interact with a specific gene product. Contextual evidence indicates that this gene product, along with FCHo2 and SGIP1, acts as a key r... | |
medium_convergence_07426 | CTNNB1 and KRAS share multiple interacting partners. One such partner is identified in the following evidence: 'We identified beta-catenin, a component of adherens junctions, as a substrate of a protein tyrosine phosphatase by a 'substrate trapping' approach and by in vitro dephosphorylation with recombinant protein ty... | lymphedema-posterior choanal atresia syndrome | Medium | convergence | {"qa_id":"medium_convergence_07426","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and KRAS share multiple interacting partners. One such partner is identified in the following evidence: 'We identified beta-catenin, a component of ad... | |
medium_convergence_07428 | SMAD7 and BMPR1B both interact with a common protein partner. Experimental evidence indicates that this shared partner interacts with TβRI and SMAD7, leading to increased ubiquitination levels of both TβRI and SMAD7. Which protein is encoded by the gene corresponding to this shared partner? | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_07428","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD7 and BMPR1B both interact with a common protein partner. Experimental evidence indicates that this shared partner interacts with TβRI and SMAD7, leading... | |
medium_convergence_07429 | Both West Nile virus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene, derived from monocyte-derived dendritic cells in study GSE136342, reports a log2 fold change of approximately 1.047 and an adjusted p-value of 0.01906. Which di... | lung cancer | Medium | convergence | {"qa_id":"medium_convergence_07429","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gen... | |
medium_convergence_07431 | ITGA4 and ITGB3 both interact with a shared protein target. Evidence regarding this target states: 'The alpha v beta 3 integrin is present on a variety of cell types and appears to act as a receptor for thrombospondin on endothelial and smooth muscle cells.' Which protein is encoded by the gene corresponding to this sh... | Thrombospondin-1 | Medium | convergence | {"qa_id":"medium_convergence_07431","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ITGA4 and ITGB3 both interact with a shared protein target. Evidence regarding this target states: 'The alpha v beta 3 integrin is present on a variety of ce... | |
medium_convergence_07433 | RC3H1 and RNF219 share common interaction partners. One such shared partner is described in evidence stating: 'We demonstrate that RNF219 is an active RING-type E3 ligase which stably associates with CCR4-NOT via NOT9 through a short linear motif (SLiM) embedded within the C-terminal low-complexity region of RNF219.' W... | CCR4-NOT transcription complex subunit 9 | Medium | convergence | {"qa_id":"medium_convergence_07433","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RC3H1 and RNF219 share common interaction partners. One such shared partner is described in evidence stating: 'We demonstrate that RNF219 is an active RING-t... | |
medium_convergence_07434 | Erythromycin and Omeprazole share a common drug interaction partner. Evidence regarding this shared partner notes that 'Currently, the orally administered erythromycin, clarithromycin, and roxithromycin have been implicated.' Which disease is this shared partner indicated for? | heart failure | Medium | convergence | {"qa_id":"medium_convergence_07434","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Erythromycin and Omeprazole share a common drug interaction partner. Evidence regarding this shared partner notes that 'Currently, the orally administered er... | |
medium_convergence_07435 | RACK1 and PTPN6 share common interaction partners. One such partner is described in evidence stating: 'We report that Tyk-2 forms stable complexes with the SH2-containing hematopoietic cell phosphatase (HCP) in several hematopoietic cell lines in vivo.' Which protein is encoded by the gene corresponding to this shared ... | Non-receptor tyrosine-protein kinase TYK2 | Medium | convergence | {"qa_id":"medium_convergence_07435","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 and PTPN6 share common interaction partners. One such partner is described in evidence stating: 'We report that Tyk-2 forms stable complexes with the S... | |
medium_convergence_07436 | TP53 and YWHAG share multiple interacting partners. One such partner is described in a study reporting that it, along with hCdc14B, interacts with the tumor suppressor protein p53 both in vitro and in vivo. Which cellular component is this specific partner located in? | centrosome | Medium | convergence | {"qa_id":"medium_convergence_07436","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TP53 and YWHAG share multiple interacting partners. One such partner is described in a study reporting that it, along with hCdc14B, interacts with the tumor ... | |
medium_convergence_07437 | HDAC2 and GATAD2A both interact with a shared protein. Evidence indicates that this shared protein associates with HDAC2 as part of the MeCP1 repression complex. Which protein is encoded by the gene corresponding to this shared entity? | Methyl-CpG-binding domain protein 2 | Medium | convergence | {"qa_id":"medium_convergence_07437","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and GATAD2A both interact with a shared protein. Evidence indicates that this shared protein associates with HDAC2 as part of the MeCP1 repression comp... | |
medium_convergence_07438 | ATF2 and CREBBP each interact with more than one shared gene product. Evidence concerning one shared entity reports that phosphorylation of this entity induced its interaction with the transcriptional co-activator cAMP-response element binding protein-binding protein. Which disease is connected to that entity through a... | arteriosclerosis disorder | Medium | convergence | {"qa_id":"medium_convergence_07438","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATF2 and CREBBP each interact with more than one shared gene product. Evidence concerning one shared entity reports that phosphorylation of this entity induc... | |
medium_convergence_07439 | EGLN3 and HSP90AA1 share multiple interacting partners. One such partner is described in evidence stating: 'We also identify a PXLE motif in HSP90 itself that can mediate binding to a prolyl hydroxylase domain protein but find that this interaction is maintained with the D4E/C127S haplotype.' Which protein is encoded b... | Egl nine homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_07439","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGLN3 and HSP90AA1 share multiple interacting partners. One such partner is described in evidence stating: 'We also identify a PXLE motif in HSP90 itself tha... | |
medium_convergence_07440 | CEBPB and CREBBP each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We show that this entity and C/EBPbeta interact in vivo through the DNA binding domain of this entity and the C terminus of C/EBPbeta common to p35/38 and p20.' Which protein is encoded by that entity? | Serum response factor | Medium | convergence | {"qa_id":"medium_convergence_07440","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPB and CREBBP each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We show that this entity and C/EBPbeta... | |
medium_convergence_07441 | PPP1CB and CAV1 share a common binding partner. Evidence indicates that Caveolin-1 (CAV1) interacts with the Type I TGF-beta receptor. Which protein, encoded by the gene corresponding to this shared binding partner, is the Type I TGF-beta receptor? | TGF-beta receptor type-1 | Medium | convergence | {"qa_id":"medium_convergence_07441","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP1CB and CAV1 share a common binding partner. Evidence indicates that Caveolin-1 (CAV1) interacts with the Type I TGF-beta receptor. Which protein, encoded... | |
medium_convergence_07443 | Human polyomavirus 1 and Influenza A virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (from study GSE135833) reports a log2 fold change of approximately 1.29 and an adjusted p-value of approximately 0.0195. Which disease is associated with this gene as a biomarker? | autism spectrum disorder | Medium | convergence | {"qa_id":"medium_convergence_07443","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Influenza A virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (from study GSE135833) ... | |
medium_convergence_07444 | CEBPB and CREBBP both interact with a specific transcription factor. Evidence indicates that this factor (along with its homolog DAF-16) interacts with the KIX and E1A/SRC interaction domains of p300/CBP, as well as the steroid receptor coactivator (SRC). In which cell type is this transcription factor enriched? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | convergence | {"qa_id":"medium_convergence_07444","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPB and CREBBP both interact with a specific transcription factor. Evidence indicates that this factor (along with its homolog DAF-16) interacts with the K... | |
medium_convergence_07446 | Both Human alphaherpesvirus 3 and Zika virus have been shown to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.796 and an adjusted p-value of 2.746e-06. Which disease is associated with genomic alterations in this sp... | acute myocardial infarction | Medium | convergence | {"qa_id":"medium_convergence_07446","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zika virus have been shown to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study ... | |
medium_convergence_07447 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -2.12 and an adjusted p-value of approximately 0.028. Which disease is associated with this gene through genomic altera... | triple-negative breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_07447","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) ... | |
medium_convergence_07449 | FANCA and DCLRE1A each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'The N terminus appears to stabilize the interaction with FANCA and FANCG and is essential for the binding of the FANCC/FANCE subcomplex.' Which protein corresponds to this description? | Fanconi anemia group F protein | Medium | convergence | {"qa_id":"medium_convergence_07449","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and DCLRE1A each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'The N terminus appears to stabil... |
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