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medium_convergence_07450 | KCND3 and KCNQ1 both enable a shared molecular function. Evidence regarding one of these functions states: 'The human cardiac fast transient outward K+ channel is composed of the KV4.3 α subunit encoded by KCND3 and the K+ channel‑interacting protein 2 (KChIP2) β subunit, and determines the early repolarization of the ... | membrane repolarization during cardiac muscle cell action potential | Medium | convergence | {"qa_id":"medium_convergence_07450","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCND3 and KCNQ1 both enable a shared molecular function. Evidence regarding one of these functions states: 'The human cardiac fast transient outward K+ chann... | |
medium_convergence_07451 | HSP90AB1 and PRKCZ both interact with a shared protein. Evidence regarding this shared entity states: 'We show that [MAPK7] interacts with the Hsp90-Cdc37 chaperone in resting cells, and that inhibition of Hsp90 or Cdc37 results in [MAPK7] ubiquitylation and proteasomal degradation.' Which protein is encoded by the gen... | Mitogen-activated protein kinase 7 | Medium | convergence | {"qa_id":"medium_convergence_07451","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AB1 and PRKCZ both interact with a shared protein. Evidence regarding this shared entity states: 'We show that [MAPK7] interacts with the Hsp90-Cdc37 ch... | |
medium_convergence_07452 | Both Human alphaherpesvirus 3 and Zika virus downregulate a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene has a log2 fold change of approximately -1.045 and an adjusted p-value of 2.407e-05. What molecular function is enabled by this gene? | methionyl-tRNA formyltransferase activity | Medium | convergence | {"qa_id":"medium_convergence_07452","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zika virus downregulate a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this ... | |
medium_convergence_07454 | Both Human alphaherpesvirus 1 and Zaire ebolavirus are reported to downregulate a specific host gene. In a study using a monocytic leukemia cell line (GSE114966), this gene exhibited a log2 fold change of -1.456 and an adjusted p-value of 0.004599. Which protein is encoded by this gene? | Prolyl hydroxylase EGLN3 | Medium | convergence | {"qa_id":"medium_convergence_07454","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Zaire ebolavirus are reported to downregulate a specific host gene. In a study using a monocytic leukemia cell line (GSE114... | |
medium_convergence_07455 | RASSF1 and LRRK2 share common interaction partners. One such shared partner is described in evidence stating: 'We recently demonstrated that LRRK2 binds to MKK6, -3, and -7.' Which protein is encoded by this shared interaction partner? | Dual specificity mitogen-activated protein kinase kinase 3 | Medium | convergence | {"qa_id":"medium_convergence_07455","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RASSF1 and LRRK2 share common interaction partners. One such shared partner is described in evidence stating: 'We recently demonstrated that LRRK2 binds to M... | |
medium_convergence_07456 | CALCOCO2 and WWP1 share multiple interacting partners. One such shared partner heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp73. Which protein is encoded by this shared partner? | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Medium | convergence | {"qa_id":"medium_convergence_07456","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CALCOCO2 and WWP1 share multiple interacting partners. One such shared partner heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates... | |
medium_convergence_07457 | DLG3 and CAMK2A both interact with a specific protein. Evidence regarding this protein states: 'We quantitatively defined the contributions of carboxyl-terminal residues to binding selectivity of the prototypic interactions of the PDZ domains of postsynaptic density protein 95 (PSD-95) and its homolog synapse-associate... | Glutamate receptor ionotropic, NMDA 2B | Medium | convergence | {"qa_id":"medium_convergence_07457","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG3 and CAMK2A both interact with a specific protein. Evidence regarding this protein states: 'We quantitatively defined the contributions of carboxyl-termi... | |
medium_convergence_07458 | EHMT2 and HDAC2 both interact with a shared protein. Evidence indicates that this shared protein associates with transcriptional repressors including KAP1, histone deacetylases HDAC1/2, and the histone methyltransferase G9a/GLP, and it modulates the interaction of HDAC1 and KAP1 with heterochromatin. Which protein is e... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 | Medium | convergence | {"qa_id":"medium_convergence_07458","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and HDAC2 both interact with a shared protein. Evidence indicates that this shared protein associates with transcriptional repressors including KAP1, h... | |
medium_convergence_07459 | GRK2 and AKT1 share common interaction partners. One such shared partner is supported by evidence stating: 'This was confirmed by the evidence that GRK2 coimmunoprecipitated with Gbetagamma subunits in an agonist-dependent manner.' Which protein is encoded by this shared interaction partner? | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | Medium | convergence | {"qa_id":"medium_convergence_07459","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRK2 and AKT1 share common interaction partners. One such shared partner is supported by evidence stating: 'This was confirmed by the evidence that GRK2 coim... | |
medium_convergence_07460 | EP300 and FOXG1 both interact with a shared transcription factor. Evidence indicates that this specific factor binds to the Trx promoter, recruits the histone acetylase p300 to that promoter, and forms a transcription activator complex, an activity that is enhanced by AICAR treatment. Which cell type is this transcript... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_07460","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and FOXG1 both interact with a shared transcription factor. Evidence indicates that this specific factor binds to the Trx promoter, recruits the histon... | |
medium_divergent_branch_00002 | HDAC5 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show that these RDs are nonredundant, and that one RD, which is conserved in the nuclear receptor corepressor and SMRT, represses transcription by interacting directly with class II HDAC4 and HDAC5.' Which diseas... | lung adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00002","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC5 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show that these RDs are nonredundant, and... | |
medium_divergent_branch_00003 | ADARB1 interacts with multiple genes. One of these interacting partners is described as a phosphorylation-dependent prolyl-isomerase that interacts with ADAR2 and acts as a positive regulator required for the nuclear localization and stability of ADAR2. Which disease is associated with this specific interacting partner... | carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00003","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADARB1 interacts with multiple genes. One of these interacting partners is described as a phosphorylation-dependent prolyl-isomerase that interacts w... | |
medium_divergent_branch_00004 | Ginkgo biloba interacts with multiple drugs. Evidence for one specific interaction notes that co-administration with etoricoxib, insulin, omeprazole, and domperidone was associated with abnormal coagulation tests without affecting reported bleeding. Which disease is the drug involved in this specific interaction indica... | myocardial infarction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00004","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Ginkgo biloba interacts with multiple drugs. Evidence for one specific interaction notes that co-administration with etoricoxib, insulin, omeprazole,... | |
medium_divergent_branch_00006 | SND1 interacts with multiple genes. One of these interaction partners is described as a protein (p100) that associates with the large subunit of RNA polymerase II and mediates the interaction between SND1 and RNA polymerase II. Which disease is associated with this specific interaction partner? | neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00006","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SND1 interacts with multiple genes. One of these interaction partners is described as a protein (p100) that associates with the large subunit of RNA ... | |
medium_divergent_branch_00007 | MAPKAP1 interacts with multiple proteins. One interaction partner is described in a study reporting that widely expressed isoforms of unstudied proteins termed Protor-1 and Protor-2 interact with this partner and are components of the mTORC2 complex. Which protein, connected to MAPKAP1 via a binding interaction, is enc... | Rapamycin-insensitive companion of mTOR | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00007","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPKAP1 interacts with multiple proteins. One interaction partner is described in a study reporting that widely expressed isoforms of unstudied prote... | |
medium_divergent_branch_00008 | CHMP1A is associated with multiple biological processes. One association is supported by evidence stating that IST1 and CHMP1 act together to recruit and modulate specific VPS4 activities required during the final stages of the process in question. Which broader biological category is this specific process a subclass o... | cellular process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00008","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHMP1A is associated with multiple biological processes. One association is supported by evidence stating that IST1 and CHMP1 act together to recruit... | |
medium_divergent_branch_00009 | SNRPG interacts with multiple proteins. One interaction partner was identified through yeast two-hybrid screens, GST pull-downs, and co-immunoprecipitations, with LSM7 and SmG reported as potential binding partners. Which protein, connected to SNRPG via an interaction, is the subject of this specific experimental evide... | Transforming acidic coiled-coil-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00009","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNRPG interacts with multiple proteins. One interaction partner was identified through yeast two-hybrid screens, GST pull-downs, and co-immunoprecipi... | |
medium_divergent_branch_00010 | BRD2 interacts with multiple genes. One of these interaction partners was reported to be directly bound and activated by BRD2 and to function as a known restrainer of R-loops. Which disease is associated with this specific gene via a biomarker relationship? | liver cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00010","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRD2 interacts with multiple genes. One of these interaction partners was reported to be directly bound and activated by BRD2 and to function as a kn... | |
medium_divergent_branch_00011 | NDUFAB1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence describing NDUFAB1 as the human mitochondrial acyl carrier protein, a nuclear-encoded subunit of complex I of the mitochondrial respiratory chain. Which cellular component, connec... | mitochondrial envelope | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00011","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NDUFAB1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence describi... | |
medium_divergent_branch_00012 | IL1RAP interacts with multiple genes. One of these interaction partners is recruited to the IL1RAP-containing complex via its association with IL-1RAcP. Which disease is associated with this specific interaction partner as a biomarker? | coronary artery disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00012","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL1RAP interacts with multiple genes. One of these interaction partners is recruited to the IL1RAP-containing complex via its association with IL-1RA... | |
medium_divergent_branch_00014 | HTATSF1 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'In nuclear extracts, small fractions of both hSPT5 and Pol II are associated with Tat-SF1 protein.' Which protein is encoded by the gene corresponding to the interacting partner identified in this evidenc... | Transcription elongation factor SPT5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00014","source_qa_id":"medium_divergent_branch_03674","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"HTATSF1 is reported to interact with multiple proteins. One specific interaction is supported by ... | |
medium_divergent_branch_00015 | TRAF5 interacts with multiple proteins. One of these interaction partners is described in literature stating: 'The intracellular domains of human and mouse [Protein X] share only 25% identity, yet both interact with TRAF5 and TRAF2.' Which protein, encoded by the gene connected to TRAF5 via this specific interaction, i... | Tumor necrosis factor receptor superfamily member 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00015","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF5 interacts with multiple proteins. One of these interaction partners is described in literature stating: 'The intracellular domains of human and... | |
medium_divergent_branch_00016 | The gene NEFH interacts with multiple partners. One interaction is supported by evidence stating: 'The amino-terminal regulatory region of a protein kinase was shown to associate with the head-rod domains of other subunits of neurofilament (neurofilament proteins M and H) as well as neurofilament L protein in yeast cel... | Serine/threonine-protein kinase N1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00016","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NEFH interacts with multiple partners. One interaction is supported by evidence stating: 'The amino-terminal regulatory region of a protein ... | |
medium_divergent_branch_00017 | ERBB2 interacts with multiple genes. One of these interacting partners is described as co-immunoprecipitating from cell lysates and associating directly in vitro with ERBB2. Which disease is associated with this specific interacting partner via a biomarker relationship? | triple-negative breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00017","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERBB2 interacts with multiple genes. One of these interacting partners is described as co-immunoprecipitating from cell lysates and associating direc... | |
medium_divergent_branch_00018 | PAX8 is associated with multiple biological processes. One association is supported by evidence stating: 'The murine Pax8 gene encodes a sequence-specific transcription factor and is expressed in the developing secretory system as well as in the developing and adult thyroid.' Which biological process, connected to the ... | endocrine system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00018","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAX8 is associated with multiple biological processes. One association is supported by evidence stating: 'The murine Pax8 gene encodes a sequence-spe... | |
medium_divergent_branch_00019 | S100P interacts with multiple proteins. One specific interaction is characterized by Ca2+-dependent complex formation that likely occurs within cells, as evidenced by the colocalization of both proteins at the plasma membrane following stimulation with growth factors or Ca2+ ionophores. Which protein, encoded by the ge... | Ezrin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00019","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"S100P interacts with multiple proteins. One specific interaction is characterized by Ca2+-dependent complex formation that likely occurs within cells... | |
medium_divergent_branch_00020 | SIRT3 interacts with multiple gene products. One of these interaction partners is supported by evidence stating that M1 and M2 proteins, but not M3, specifically interact with the protein encoded by this partner. Which protein is encoded by the gene corresponding to this specific interaction partner? | 60 kDa heat shock protein, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00020","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIRT3 interacts with multiple gene products. One of these interaction partners is supported by evidence stating that M1 and M2 proteins, but not M3, ... | |
medium_divergent_branch_00021 | STX18 interacts with multiple proteins. One interaction partner is described as forming a subcomplex with RINT-1 (Rad50-interacting protein) and p31 within a larger complex that includes syntaxin 18, an endoplasmic reticulum-localized t-SNARE involved in membrane trafficking. Which protein corresponds to this descripti... | Centromere/kinetochore protein zw10 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00021","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX18 interacts with multiple proteins. One interaction partner is described as forming a subcomplex with RINT-1 (Rad50-interacting protein) and p31 ... | |
medium_divergent_branch_00022 | CDKN1A interacts with multiple proteins. One interaction partner is implicated in the degradation of p27, a process that can be inhibited by compounds reducing binding through key compound-receptor contacts. Which cellular component is this specific interaction partner located in? | SCF ubiquitin ligase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00022","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDKN1A interacts with multiple proteins. One interaction partner is implicated in the degradation of p27, a process that can be inhibited by compound... | |
medium_divergent_branch_00023 | WNT7A is implicated in multiple biological processes. One specific connection is supported by evidence stating that Wnts 7a and 7b stimulate the proliferation of neurogenic progenitors and increase the number of cells capable of generating primary neurospheres. Which biological process, connected to the process describ... | forebrain development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00023","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT7A is implicated in multiple biological processes. One specific connection is supported by evidence stating that Wnts 7a and 7b stimulate the prol... | |
medium_divergent_branch_00024 | DLGAP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using the PDZ domains of a member of the SHANK family and 2 as bait in the yeast two-hybrid system, we isolated several clones of the SAPAP/GKAP (SAP90/PSD-95-associated protein/guanylate kinase-associated protein) fami... | SH3 and multiple ankyrin repeat domains protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00024","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLGAP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using the PDZ domains of a member of the SHANK f... | |
medium_divergent_branch_00026 | The transcription factor NKX2-5 is involved in multiple biological processes. One specific process is supported by evidence stating that mutant mice display a hypoplastic atrioventricular (AV) node at birth and subsequently develop selective dropout of these conduction cells. Which broader biological process is the ide... | cardiac muscle tissue development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00026","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The transcription factor NKX2-5 is involved in multiple biological processes. One specific process is supported by evidence stating that mutant mice ... | |
medium_divergent_branch_00027 | The FOS protein interacts with multiple partners. One specific interaction partner is described in evidence stating: 'Second, ASC-2 specifically interacted with the activating protein-1 (AP-1) components c-Jun and c-Fos as well as the nuclear factor-kappaB (NFkappaB) components p50 and p65, as demonstrated by the gluta... | prostate cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00027","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The FOS protein interacts with multiple partners. One specific interaction partner is described in evidence stating: 'Second, ASC-2 specifically inte... | |
medium_divergent_branch_00028 | The biological process 'positive regulation of isotype switching' is defined as any process that activates or increases the frequency, rate, or extent of isotype switching. This process is a subtype of a broader biological process. Which biological process is positively regulated by this broader parent process? | DNA recombination | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00028","source_qa_id":"medium_divergent_branch_01185","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'positive regulation of isotype switching' is defined as any process that ... | |
medium_divergent_branch_00030 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.414 and an adjusted p-value of 0.000939. Which protein does that selected gene encode? | ATP synthase F(1) complex subunit gamma, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00030","source_qa_id":"medium_divergent_branch_04315","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_00031 | The truncus arteriosus is a type of anatomical structure. Evidence indicates that the truncus arteriosus and the bulbus cordis are divided by the aorticopulmonary septum, and that the truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. Based on this evidence, which specific anatomical category... | heart vasculature | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00031","source_qa_id":"medium_divergent_branch_00516","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The truncus arteriosus is a type of anatomical structure. Evidence indicates that the truncus art... | |
medium_divergent_branch_00033 | FIGNL1 interacts with multiple proteins. One specific interaction involves a partner described as a scaffolding protein involved in DNA repair, which acts with FIGNL1 in homologous recombination (HR) repair. Which cellular component is this specific partner protein located in? | nuclear chromosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00033","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FIGNL1 interacts with multiple proteins. One specific interaction involves a partner described as a scaffolding protein involved in DNA repair, which... | |
medium_divergent_branch_00035 | ADAM9 is associated with multiple biological processes. One association is supported by evidence that keratinocytes adhering to the immobilized disintegrin-cysteine-rich domain of ADAM9 exhibited increased motility. Which biological process is positively regulated by the specific process linked to this evidence? | keratinocyte migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00035","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAM9 is associated with multiple biological processes. One association is supported by evidence that keratinocytes adhering to the immobilized disin... | |
medium_divergent_branch_00036 | DNMT3A interacts with multiple proteins. For one of these interaction partners, experimental evidence indicates that Histone H3 (specifically excluding the H3K4me3 modification) disrupts the ADD-CD interaction, induces a large conformational movement of the ADD domain, and thereby releases the autoinhibition of DNMT3A.... | Histone H3.3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00036","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNMT3A interacts with multiple proteins. For one of these interaction partners, experimental evidence indicates that Histone H3 (specifically excludi... | |
medium_divergent_branch_00037 | CD55 is associated with multiple biological processes. One association is supported by evidence stating: 'The present study demonstrates that coengagement of CD55, using either cross-linking mAbs or its natural ligand CD97, and CD3 results in enhanced proliferation of human peripheral blood CD4(+) T cells, expression o... | CD4-positive, alpha-beta T cell activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00037","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD55 is associated with multiple biological processes. One association is supported by evidence stating: 'The present study demonstrates that coengag... | |
medium_divergent_branch_00038 | TBK1 interacts with multiple genes. One specific interaction is supported by TAP studies showing that three proteins expressed in HEK-293T cells (NAP1, TANK, and the target gene) interact with TBK1. Which gene is this? | RB1CC1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00038","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBK1 interacts with multiple genes. One specific interaction is supported by TAP studies showing that three proteins expressed in HEK-293T cells (NAP... | |
medium_divergent_branch_00039 | The biological process 'antigen processing and presentation of peptide antigen via MHC class II' is enabled by multiple cell types. One such cell type is described as a fully differentiated eosinophil: a granular leukocyte with a bi-lobed nucleus connected by slender threads, cytoplasm containing coarse, round, eosin-s... | band form eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00039","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process 'antigen processing and presentation of peptide antigen via MHC class II' is enabled by multiple cell types. One such cell typ... | |
medium_divergent_branch_00040 | The pancreatic epithelial bud develops from a specific anatomical structure. Evidence indicates that the embryonic pancreas arises from two separate anlagen within the epithelium of this structure, specifically one dorsal and two ventral pancreatic buds. Which anatomical entity is the direct developmental origin of the... | subdivision of digestive tract | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00040","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The pancreatic epithelial bud develops from a specific anatomical structure. Evidence indicates that the embryonic pancreas arises from two separate ... | |
medium_divergent_branch_00041 | KCND3 enables a molecular function related to cardiac action potential repolarization. Evidence indicates that the human cardiac fast transient outward K+ channel, composed of the KV4.3 α subunit (encoded by KCND3) and the KChIP2 β subunit, determines the early repolarization of the action potential. Which biological p... | membrane repolarization during cardiac muscle cell action potential | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00041","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCND3 enables a molecular function related to cardiac action potential repolarization. Evidence indicates that the human cardiac fast transient outwa... | |
medium_divergent_branch_00042 | Cholecystokinin (CCK) interacts with multiple proteins. One interaction is supported by evidence stating that probes bound to type B CCK receptors in a saturable and specific manner and acted as full agonists. Which protein is encoded by the gene associated with this specific receptor interaction? | Gastrin/cholecystokinin type B receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00042","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cholecystokinin (CCK) interacts with multiple proteins. One interaction is supported by evidence stating that probes bound to type B CCK receptors in... | |
medium_divergent_branch_00043 | LGR5 interacts with multiple genes. Evidence for one of these interactions describes a low-resolution ternary complex structure involving LGR5, R-spondin 2, and the target protein. Which disease is associated with this target gene through genomic alterations? | primary angle-closure glaucoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00043","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LGR5 interacts with multiple genes. Evidence for one of these interactions describes a low-resolution ternary complex structure involving LGR5, R-spo... | |
medium_divergent_branch_00045 | TRIM9 interacts with multiple proteins. One specific interaction involves the phosphorylated degron motif of the interacting partner binding to the WD40 repeat region of β-TrCP, which prevents β-TrCP from binding its substrates, thereby stabilizing IκBα and p100 and blocking NF-κB activation. Which protein, encoded by ... | F-box/WD repeat-containing protein 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00045","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM9 interacts with multiple proteins. One specific interaction involves the phosphorylated degron motif of the interacting partner binding to the W... | |
medium_divergent_branch_00046 | The gene OLFM1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 2.26 TPM, a z-score of 2.39, and a fold enrichment of 9.15. Which cell type corresponds to this specific statistical profile? | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00046","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene OLFM1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 2.26 TPM, a z... | |
medium_divergent_branch_00047 | PLD1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Use of actin polymerization-specific reagents indicated that PLD1 binds both monomeric G-actin, as well as actin filaments.' Which protein, connected to PLD1 via this specific interaction evidence, is encoded by the gene in questi... | Actin, cytoplasmic 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00047","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLD1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Use of actin polymerization-specific reagents indicated tha... | |
medium_divergent_branch_00048 | KLF5 interacts with multiple genes. One specific interaction is characterized by the partner protein directly binding to KLF5, thereby decreasing KLF5's ubiquitination and subsequent degradation. What molecular function is enabled by this specific interacting partner? | cysteine-type deubiquitinase activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00048","source_qa_id":"medium_divergent_branch_04997","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"KLF5 interacts with multiple genes. One specific interaction is characterized by the partner prot... | |
medium_divergent_branch_00049 | The gene CLSPN interacts with multiple proteins. One specific interaction partner is required to maintain the steady-state levels of Claspin (the protein encoded by CLSPN) and has been shown to interact with Claspin in vivo. Which protein is encoded by the gene corresponding to this specific interaction partner? | Ubiquitin carboxyl-terminal hydrolase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00049","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CLSPN interacts with multiple proteins. One specific interaction partner is required to maintain the steady-state levels of Claspin (the pro... | |
medium_divergent_branch_00050 | KAT6A interacts with multiple proteins. One interaction is supported by evidence describing crystal structures of the DPF domain of MOZ in complex with H3K14cr, H3K14bu, and H3K14pr peptides, revealing that these non-acetyl acylations are anchored in a hydrophobic 'dead-end' pocket with selectivity for crotonylation ar... | Histone H3.1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00050","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KAT6A interacts with multiple proteins. One interaction is supported by evidence describing crystal structures of the DPF domain of MOZ in complex wi... | |
medium_divergent_branch_00051 | MTA1 interacts with multiple proteins. One specific interaction involves a complex containing HDAC1/2, RbAp46/48, and MBD3, but explicitly excluding Sin3 or Mi2. Which protein, known to bind MTA1, is part of this specific complex composition? | Histone-binding protein RBBP4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00051","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTA1 interacts with multiple proteins. One specific interaction involves a complex containing HDAC1/2, RbAp46/48, and MBD3, but explicitly excluding ... | |
medium_divergent_branch_00052 | ACTG1 is associated with multiple biological processes. One association is supported by evidence stating: 'These experiments demonstrate unique roles of β-CYA and γ-CYA in regulating the steady-state integrity of AJs and TJs, respectively.' Identify the biological process connected to this specific process via an 'is a... | protein localization to cell-cell junction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00052","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACTG1 is associated with multiple biological processes. One association is supported by evidence stating: 'These experiments demonstrate unique roles... | |
medium_divergent_branch_00053 | CHFR interacts with multiple genes. One specific interaction is characterized by the finding that CHFR binds to and ubiquitinates the partner protein, leading to its degradation. Which disease is associated with this specific interacting partner via a biomarker relationship? | kidney neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00053","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHFR interacts with multiple genes. One specific interaction is characterized by the finding that CHFR binds to and ubiquitinates the partner protein... | |
medium_divergent_branch_00054 | MYD88 interacts with multiple proteins. One specific interaction involves a protein whose Src homology 2-like domain binds to both MYD88 and IkappaB kinase (IKK)-alphabeta, forming a functional MYD88-protein-IKK-alphabeta complex, while notably failing to bind TNFR-associated factor 6 or IL-1R-associated kinase 1. Whic... | STAT3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00054","source_qa_id":"medium_divergent_branch_06880","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MYD88 interacts with multiple proteins. One specific interaction involves a protein whose Src hom... | |
medium_divergent_branch_00055 | MRE11A interacts with multiple proteins. One interaction partner is described by the evidence: 'This protein-protein interaction surface is able to bind several checkpoint proteins, including ATRIP, RAD9, and MRE11.' Which disease is associated with this specific interaction partner? | pulmonary fibrosis and/or bone marrow failure, telomere-related, 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00055","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MRE11A interacts with multiple proteins. One interaction partner is described by the evidence: 'This protein-protein interaction surface is able to b... | |
medium_divergent_branch_00056 | BRAP interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interaction between these two proteins is confirmed by co-immunoprecipitation in human HEK 293T cells.' Which protein product is encoded by the gene corresponding to this specific interacting partner? | Dual specificity protein phosphatase CDC14A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00056","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRAP interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interaction between these two proteins is conf... | |
medium_divergent_branch_00057 | ZBTB33 (also known as Kaiso) interacts with multiple proteins. One specific interaction is described by the evidence: 'Here we demonstrate that Kaiso, a methyl CpG binding protein belonging to the BTB/POZ family of transcription factors, is a component of the human [complex containing the target protein]. Which protein... | Nuclear receptor corepressor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00057","source_qa_id":"medium_divergent_branch_00796","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ZBTB33 (also known as Kaiso) interacts with multiple proteins. One specific interaction is descri... | |
medium_divergent_branch_00058 | GEMIN5 interacts with multiple proteins. One of these interaction partners is described as interacting with several snRNP core proteins, including SmB, SmD1, SmD2, SmD3, and a protein encoded by the SNRPE gene, suggesting participation in the activities of the SMN complex in snRNP assembly. Which disease is associated ... | hypotrichosis 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00058","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GEMIN5 interacts with multiple proteins. One of these interaction partners is described as interacting with several snRNP core proteins, including Sm... | |
medium_divergent_branch_00059 | The protein PZP is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 2.53 TPM, a z-score of 2.50, and a fold enrichment of 8.35. Which cell type, connected to PZP via this enrichment evidence, is a subtype of mature alpha-beta T cells? | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00059","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein PZP is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 2.53 TPM, a ... | |
medium_divergent_branch_00060 | MARK2 interacts with multiple proteins. One of these interaction partners recruits a subpopulation of PAR-1b (which corresponds to MARK2 in mammals) to apicobasal microtubule bundles, and this interaction is essential for the partner-dependent development of these bundles. Which protein is encoded by the gene correspon... | Microtubule cross-linking factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00060","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARK2 interacts with multiple proteins. One of these interaction partners recruits a subpopulation of PAR-1b (which corresponds to MARK2 in mammals) ... | |
medium_divergent_branch_00061 | CXCL10 is associated with multiple biological processes. One association is supported by evidence showing that treatment of endothelial cells with IP-10 in the presence of vascular endothelial growth factor (VEGF) inhibited tube formation on growth factor-reduced Matrigel and in a subcutaneous Matrigel plug. Which biol... | regulation of morphogenesis of an epithelium | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00061","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXCL10 is associated with multiple biological processes. One association is supported by evidence showing that treatment of endothelial cells with IP... | |
medium_divergent_branch_00063 | The gene DYNC1LI1 interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'In vitro pull-down assays demonstrated that this protein directly binds to the cytoplasmic dynein 1 light intermediate chain 2.' Which protein is encoded by the gene that interacts with DYNC1LI1 a... | Breast cancer type 2 susceptibility protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00063","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DYNC1LI1 interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'In vitro pull-down assays... | |
medium_divergent_branch_00064 | PIK3C3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'In fact, we demonstrate that the laforin/malin complex interacts physically and co-localizes intracellularly with core components of the PI3KC3 complex (Beclin1, Vps34 and Vps15), and that this interaction is specific and ... | Lafora disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00064","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIK3C3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'In fact, we demonstrate that the laforin/malin comp... | |
medium_divergent_branch_00065 | The gene NR5A2 (encoding LRH-1) has multiple reported protein-protein interactions. One specific interaction is supported by evidence stating: 'In vitro/in vivo glutathione S-transferase pulldown experiments demonstrated that the basic helix-loop-helix-leucine zipper domain in SREBP-2 binds to the ligand-binding domain... | Sterol regulatory element-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00065","source_qa_id":"medium_divergent_branch_00923","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene NR5A2 (encoding LRH-1) has multiple reported protein-protein interactions. One specific ... | |
medium_divergent_branch_00066 | MCM4 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'MCM2 and MCM4 were then shown to interact with the protein encoded by UBE3A.' Which protein is encoded by the gene corresponding to this interaction partner? | Ubiquitin-protein ligase E3A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00066","source_qa_id":"medium_divergent_branch_03105","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MCM4 is reported to interact with multiple proteins. One specific interaction is supported by evi... | |
medium_divergent_branch_00067 | TRIM3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show that the ubiquitin E3 ligase TRIM3, also known as BERP, interacts with the target protein via its RBCC domain.' Which protein is this target, and what is the name of the protein product encoded by the gene f... | Kinesin-like protein KIF21B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00067","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show that the ubiquitin E3 ligase TRIM3, ... | |
medium_divergent_branch_00068 | RAF1 interacts with multiple proteins. One specific interaction is described by the following evidence: 'A specific protein specifically associates with several components of the ERK pathway, including MP1, Raf-1, MEK, and ERK, and stabilizes their assembly into an oligomeric complex.' Based on this description, which ... | WD repeat domain-containing protein 83 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00068","source_qa_id":"medium_divergent_branch_06903","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RAF1 interacts with multiple proteins. One specific interaction is described by the following evi... | |
medium_divergent_branch_00069 | ITGB4 interacts with multiple genes. One of these interacting partners forms a complex with the alpha6beta4 integrin, the receptor tyrosine kinase ErbB2, and the cytoplasmic kinase Fyn in A431 cells, specifically via its C2 region. Which protein is encoded by this interacting gene? | Syndecan-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00069","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGB4 interacts with multiple genes. One of these interacting partners forms a complex with the alpha6beta4 integrin, the receptor tyrosine kinase Er... | |
medium_divergent_branch_00070 | The gene AIF1 is associated with multiple biological processes. One association is supported by evidence stating: 'This study indicates that AIF-1 enhances VSMC growth by autocrine production of G-CSF.' Identify the biological process that is positively regulated by the process linked to this specific evidence. | smooth muscle cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00070","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AIF1 is associated with multiple biological processes. One association is supported by evidence stating: 'This study indicates that AIF-1 en... | |
medium_divergent_branch_00071 | TERF1 interacts with multiple proteins. One specific interaction partner is characterized by evidence showing it interacts with TRF1 in vitro and in cells, and co-localizes with TRF1 in nuclei and metaphase chromosomes. Which disease is associated with this specific interaction partner through genomic alterations? | Revesz syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00071","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TERF1 interacts with multiple proteins. One specific interaction partner is characterized by evidence showing it interacts with TRF1 in vitro and in ... | |
medium_divergent_branch_00072 | PKM interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrate here that EGFR activation results in c-Src-mediated [Gene A] phosphorylation at Y59, which interacts with nuclear pyruvate kinase M2 (PKM2).' Identify the disease connected to [Gene A] through a therapeutic relationship... | autosomal recessive polycystic kidney disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00072","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PKM interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrate here that EGFR activation results in c-Src-media... | |
medium_divergent_branch_00073 | The gene ADORA2A is associated with multiple biological processes. One association is supported by evidence showing that blood pressure and heart rate were increased, as well as platelet aggregation. Which biological process, defined as a parent term (is_a) of the process linked by this specific evidence, is the correc... | circulatory system process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00073","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ADORA2A is associated with multiple biological processes. One association is supported by evidence showing that blood pressure and heart rat... | |
medium_divergent_branch_00074 | UBE4B interacts with multiple genes. One specific interaction is supported by evidence stating: 'With a yeast two-hybrid screen, we have now identified a protein as a protein that interacts with E4B.' Which cellular component is the gene identified in this evidence located in? | Golgi apparatus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00074","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE4B interacts with multiple genes. One specific interaction is supported by evidence stating: 'With a yeast two-hybrid screen, we have now identifi... | |
medium_divergent_branch_00075 | PTPN12 interacts with multiple genes. One interaction is supported by evidence stating: 'Previously, we demonstrated that the PEST-type protein-tyrosine phosphatase, PTP HSCF (hematopoietic stem cell fraction), bound to a novel cytoskeletal associated protein, proline serine threonine phosphatase interacting protein (P... | hyperzincemia with functional zinc depletion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00075","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPN12 interacts with multiple genes. One interaction is supported by evidence stating: 'Previously, we demonstrated that the PEST-type protein-tyros... | |
medium_divergent_branch_00076 | PLEKHA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that immunoprecipitation of endogenously expressed TAPP1 from 293-cell lysates results in the co-immunoprecipitation of endogenous [Protein X], indicating that these proteins are likely to interact with each othe... | Multiple PDZ domain protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00076","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLEKHA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that immunoprecipitation of endogenously ... | |
medium_divergent_branch_00077 | Human polyomavirus 2 upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.190 and an adjusted p-value of 0.000609. Which protein does that selected gene encode? | Basal body-orientation factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00077","source_qa_id":"medium_divergent_branch_01409","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human polyomavirus 2 upregulates several genes. In the recorded experiment, one branch showed ... | |
medium_divergent_branch_00078 | BNIP3 is involved in multiple biological processes. One of these processes is supported by evidence stating: 'We show that BNIP3 interacts with Opa1, leading to mitochondrial fragmentation and apoptosis.' Which biological process is positively regulated by the specific process linked to BNIP3 via this evidence? | mitochondrial fission | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00078","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BNIP3 is involved in multiple biological processes. One of these processes is supported by evidence stating: 'We show that BNIP3 interacts with Opa1,... | |
medium_divergent_branch_00079 | TANK interacts with multiple proteins. One interaction is supported by TAP studies in HEK-293T cells showing that NAP1, the target protein, and TBKBP1 all interact with the target protein. Which protein is encoded by the gene corresponding to this target protein? | Serine/threonine-protein kinase TBK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00079","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TANK interacts with multiple proteins. One interaction is supported by TAP studies in HEK-293T cells showing that NAP1, the target protein, and TBKBP... | |
medium_divergent_branch_00080 | The NBN gene interacts with multiple proteins. One specific interaction partner is described as forming a basal preassembled complex with NBS1 in non-damaged cells. Which protein is encoded by the gene corresponding to this interaction partner? | Serine/threonine-protein kinase VRK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00080","source_qa_id":"medium_divergent_branch_06122","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The NBN gene interacts with multiple proteins. One specific interaction partner is described as f... | |
medium_divergent_branch_00081 | BRCA2 is known to bind multiple partner proteins. One specific interaction involves a meiosis-specific recombinase, where the primary interaction site on BRCA2 has been mapped to a 26 amino-acid region (residues 2386-2411). Which gene product, connected to BRCA2 via this specific binding interaction, is the subject of ... | MSH4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00081","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRCA2 is known to bind multiple partner proteins. One specific interaction involves a meiosis-specific recombinase, where the primary interaction sit... | |
medium_divergent_branch_00083 | SIK3 interacts with multiple proteins. One interaction is supported by evidence stating: 'This phosphorylation coincides with increased 14-3-3 binding to SIK3 in these cell types.' Which protein, connected to SIK3 via a binding interaction, is encoded by the gene associated with this specific evidence? | 14-3-3 protein epsilon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00083","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIK3 interacts with multiple proteins. One interaction is supported by evidence stating: 'This phosphorylation coincides with increased 14-3-3 bindin... | |
medium_divergent_branch_00084 | The gene AK085865 regulates more than one cell type. Experimental evidence indicates that knocking down AK085865 diminishes the phenotypical expression of M2 macrophages while promoting polarization to the M1 phenotype. Based on this evidence, which cell type is the target of regulation by AK085865, and what is the cel... | mature CD4 single-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00084","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AK085865 regulates more than one cell type. Experimental evidence indicates that knocking down AK085865 diminishes the phenotypical expressi... | |
medium_divergent_branch_00085 | The protein GET3 interacts with multiple partners. One specific interaction is characterized by structural evidence stating: 'The structures reveal that Get3 helix 8 and the [partner] C terminus form a composite lid over the Get3 substrate-binding chamber that is opened by SGTA.' Based on this structural description, i... | congenital disorder of glycosylation, type IIy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00085","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein GET3 interacts with multiple partners. One specific interaction is characterized by structural evidence stating: 'The structures reveal t... | |
medium_divergent_branch_00087 | FKBP1A interacts with multiple gene products. One specific interaction is characterized by the following evidence: 'The skeletal muscle sarcoplasmic reticulum (SR) Ca2+ release channel or ryanodine receptor binds four molecules of FKBP12, and the interaction of FKBP12 with this receptor regulates both unitary and coupl... | Ryanodine receptor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00087","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FKBP1A interacts with multiple gene products. One specific interaction is characterized by the following evidence: 'The skeletal muscle sarcoplasmic ... | |
medium_divergent_branch_00088 | TRIM33 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we employ interaction proteomics to uncover the signaling protein TIF1γ as a specific interactor of SnoN1 but not the closely related isoform SnoN2.' Which protein, connected to TRIM33 via an interaction, is encoded by the ... | Ski-like protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00088","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM33 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we employ interaction proteomics to uncover the sign... | |
medium_divergent_branch_00089 | GNB3 interacts with multiple G-protein gamma subunits. One specific interaction is supported by evidence stating: 'The data show that PhLP1 plays a vital role in the assembly of Ggamma2 with all four Gbeta1-4 subunits and in the assembly of Gbeta2 with all twelve Ggamma subunits, without affecting the specificity of th... | basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00089","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNB3 interacts with multiple G-protein gamma subunits. One specific interaction is supported by evidence stating: 'The data show that PhLP1 plays a v... | |
medium_divergent_branch_00090 | The dopamine D1 receptor (DRD1) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The D1 receptor was found to co-precipitate and associate in vitro directly with the gamma-subunit of the COPI coatomer complex.' Which cellular component is the location of the protein identifi... | Golgi membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00090","source_qa_id":"medium_divergent_branch_04705","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The dopamine D1 receptor (DRD1) interacts with multiple proteins. One specific interaction is sup... | |
medium_divergent_branch_00091 | The gene CHAF1A interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Furthermore, we demonstrate that hAsf1 proteins can interact directly with the p60 subunit of hCAF-1.' Which protein is encoded by the gene that interacts with CHAF1A in this specific context? | Histone chaperone ASF1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00091","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CHAF1A interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Furthermore, we demonstrate that hAs... | |
medium_divergent_branch_00092 | The gene ADAMTSL4 is enriched in multiple cell types. One specific cell type shows a mean expression of 4.65 TPM, a z-score of 2.20, and a fold enrichment of 5.88. Which cell type does this specific cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00092","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ADAMTSL4 is enriched in multiple cell types. One specific cell type shows a mean expression of 4.65 TPM, a z-score of 2.20, and a fold enric... | |
medium_divergent_branch_00093 | PIAS1 interacts with multiple proteins. One specific interaction is described by the evidence: 'We found SUMO-E2-conjugating enzyme Ubc9 and SUMO-E3 ligase Pias1 as novel interaction partners of a nuclear receptor corepressor.' Which protein is encoded by the gene corresponding to this interaction partner? | Nuclear receptor corepressor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00093","source_qa_id":"medium_divergent_branch_04925","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PIAS1 interacts with multiple proteins. One specific interaction is described by the evidence: 'W... | |
medium_divergent_branch_00094 | Orthohepevirus A upregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of 1.074 and an adjusted p-value of 0.0325. Which molecular function is enabled by the gene corresponding to this specific evidence? | RNA binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00094","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Orthohepevirus A upregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of 1.074 and an adjusted p-value... | |
medium_divergent_branch_00095 | LAGE3 is reported to bind multiple proteins. One specific interaction is described in a study that mined the PRAME interactome, identifying specific interactions with LAGE3 and another protein, noting that both are human orthologues of the ancient EKC/KEOPS complex. Which protein, linked to LAGE3 by this binding relati... | tRNA N6-adenosine threonylcarbamoyltransferase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00095","source_qa_id":"medium_divergent_branch_04904","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"LAGE3 is reported to bind multiple proteins. One specific interaction is described in a study tha... | |
medium_divergent_branch_00096 | RPRD1A interacts with multiple proteins. One of these interaction partners is an E3 ubiquitin ligase that targets p62; evidence indicates that RPRD1A competitively interacts with this ligase, leading to decreased p62 ubiquitination and increased sequestration of Keap1. Which protein is encoded by the gene corresponding... | E3 ubiquitin-protein ligase TRIM21 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00096","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPRD1A interacts with multiple proteins. One of these interaction partners is an E3 ubiquitin ligase that targets p62; evidence indicates that RPRD1A... | |
medium_divergent_branch_00097 | CDK9 is associated with multiple biological processes. One association is supported by evidence stating: 'While ectopic expression of cdk2 together with its regulatory subunits (cyclins E and A) inhibits myogenic transcription, overproduction of CDK9 and its associated cyclin (cyclin T2a) strengthens MyoD-dependent tra... | regulation of cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00097","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK9 is associated with multiple biological processes. One association is supported by evidence stating: 'While ectopic expression of cdk2 together w... | |
medium_divergent_branch_00098 | The gene PTH1R is associated with multiple genes via binding interactions. One specific interaction is supported by evidence stating that Parathyroid hormone (PTH) and a related protein are calciotropic hormones that interact with a shared seven-transmembrane domain G protein-coupled receptor, predominantly located in ... | Parathyroid hormone-related protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00098","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PTH1R is associated with multiple genes via binding interactions. One specific interaction is supported by evidence stating that Parathyroid... | |
medium_divergent_branch_00100 | PRKCD interacts with multiple proteins. One specific interaction is characterized by the following evidence: Treatment of HeLa cells with etoposide results in the phosphorylation of the interacting partner on Serine 727 and its subsequent association with PKCdelta. Which disease is linked to this specific interacting p... | esophageal candidiasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00100","source_qa_id":"medium_divergent_branch_03591","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PRKCD interacts with multiple proteins. One specific interaction is characterized by the followin... | |
medium_divergent_branch_00101 | The gene ACTC1 is associated with multiple biological processes. One association is supported by evidence stating: 'The in vitro motility for the E99K mutant was consistently lower than WT over a range of ionic strengths, which is likely related to the lower average force supported by the mutant actin.' Identify the bi... | actin filament-based process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00101","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACTC1 is associated with multiple biological processes. One association is supported by evidence stating: 'The in vitro motility for the E99... | |
medium_divergent_branch_00103 | ITGB4 interacts with multiple proteins. One interaction is supported by evidence from a yeast two-hybrid screen using the beta4 cytodomain, which identified a protein called p27(BBP) as a beta4 interactor. Which protein, connected to ITGB4 via this specific interaction evidence, is encoded by the gene in question? | Eukaryotic translation initiation factor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00103","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGB4 interacts with multiple proteins. One interaction is supported by evidence from a yeast two-hybrid screen using the beta4 cytodomain, which ide... |
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