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medium_divergent_branch_00104 | The gene ADD2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'These findings suggest that tyrosine-phosphorylated beta-adducin associates with the SH2 domain of this protein and colocalizes under plasma membranes.' Which protein is encoded by the gene that interacts with AD... | Tyrosine-protein kinase Fyn | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00104","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ADD2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'These findings suggest that tyrosine-phos... | |
medium_divergent_branch_00105 | PBK interacts with multiple proteins. Evidence for one of these interactions indicates that TOPK binds to the partner protein, as well as to cdk1/cyclin B1 and microtubules, via a unique region near its C terminus. Which protein is the partner of PBK in this specific interaction context? | Protein regulator of cytokinesis 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00105","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PBK interacts with multiple proteins. Evidence for one of these interactions indicates that TOPK binds to the partner protein, as well as to cdk1/cyc... | |
medium_divergent_branch_00106 | PITX1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'A novel OTX-related homeodomain transcription factor has been identified on the basis of its ability to interact with the transactivation domain of the pituitary-specific POU domain protein, a POU domain transcription fact... | empty sella syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00106","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PITX1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'A novel OTX-related homeodomain transcription facto... | |
medium_divergent_branch_00108 | The gene ITSN2 is known to interact with multiple partners. One specific interaction is supported by evidence stating: 'Intersectin-2Long (ITSN2L) is a multi-domain protein participating in endocytosis and exocytosis. In this study, [Partner] was identified as a novel ITSN2L interacting protein using a yeast two-hybrid... | RABEP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00108","source_qa_id":"medium_divergent_branch_01208","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene ITSN2 is known to interact with multiple partners. One specific interaction is supported... | |
medium_divergent_branch_00109 | WDR45 interacts with multiple proteins. One of these interaction partners forms a complex with WIPI4 (which is WDR45 itself) that tethers a PI3P-containing vesicle to a PI3P-free vesicle. Which protein, encoded by the gene interacting with WDR45 in this specific context, is the subject of this description? | Autophagy-related protein 2 homolog A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00109","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WDR45 interacts with multiple proteins. One of these interaction partners forms a complex with WIPI4 (which is WDR45 itself) that tethers a PI3P-cont... | |
medium_divergent_branch_00110 | HIP1R is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'The rHIP1R protein was enriched in the synaptic plasma membrane fraction along with huntingtin, a synaptic protein and a causal protein for Huntington's disease.' Which ce... | plasma membrane region | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00110","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIP1R is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: '... | |
medium_divergent_branch_00111 | The gene LAT interacts with multiple proteins. One specific interaction involves a partner that also associates with a kinase via a proline-rich motif and translocates into glycolipid-enriched microdomains (lipid rafts) following TCR/CD3 stimulation. Which protein is encoded by the gene that binds to LAT in this specif... | Mitogen-activated protein kinase kinase kinase kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00111","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene LAT interacts with multiple proteins. One specific interaction involves a partner that also associates with a kinase via a proline-rich moti... | |
medium_divergent_branch_00113 | CHEK1 interacts with multiple genes. One of these interaction partners is a dual-specificity protein phosphatase that controls cell cycle transitions by dephosphorylating cyclin-dependent kinases; in vitro evidence shows Chk1 binds to and phosphorylates this entity (along with Cdc25A and Cdc25B). Which disease is conne... | breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00113","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHEK1 interacts with multiple genes. One of these interaction partners is a dual-specificity protein phosphatase that controls cell cycle transitions... | |
medium_divergent_branch_00114 | MID2 interacts with multiple proteins. One interaction partner is characterized by the finding that its coiled-coil motifs mediate both homo- and hetero-dimerisation, and that this dimerisation is a prerequisite for the association of the MID-Alpha 4 complex with microtubules. Which protein, connected to MID2 via an in... | E3 ubiquitin-protein ligase Midline-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00114","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MID2 interacts with multiple proteins. One interaction partner is characterized by the finding that its coiled-coil motifs mediate both homo- and het... | |
medium_divergent_branch_00115 | GPC4 interacts with multiple proteins. Evidence suggests that the interaction between GPC4 and one of these partners promotes the proteasome-dependent ubiquitination of GPC4. Which protein, encoded by the gene connected to GPC4 via this specific interaction, is the partner in question? | Platelet glycoprotein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00115","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPC4 interacts with multiple proteins. Evidence suggests that the interaction between GPC4 and one of these partners promotes the proteasome-dependen... | |
medium_divergent_branch_00116 | C11orf30 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Here we identify a protein, EMSY, which binds this partner within a region (exon 3) deleted in cancer.' Which protein product is encoded by the gene corresponding to this interaction partner? | Breast cancer type 2 susceptibility protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00116","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"C11orf30 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Here we identify a protein, EMSY, whic... | |
medium_divergent_branch_00117 | The gene PIK3CB is associated with multiple biological processes. One specific association is supported by evidence stating that 'Both PI3Kbeta and PI3Kgamma isoforms are required for full migration induced by S1P.' Identify the biological process that is positively regulated by the process linked to PIK3CB via this sp... | endothelial cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00117","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PIK3CB is associated with multiple biological processes. One specific association is supported by evidence stating that 'Both PI3Kbeta and P... | |
medium_divergent_branch_00118 | The protein ACTL6B is associated with multiple biological processes. One association is supported by evidence stating that engineered knock-out of ACTL6B in wild-type human neurons resulted in profound deficits in dendrite development. Which broader biological process category is the specific process linked to this evi... | cell maturation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00118","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein ACTL6B is associated with multiple biological processes. One association is supported by evidence stating that engineered knock-out of AC... | |
medium_divergent_branch_00119 | LRP5 is implicated in multiple biological processes. One specific connection is supported by evidence stating that LRP5 mutations and Wnt signaling levels determine the differentiation fate of human mesenchymal stem cells (hMSCs) into either osteoblasts or adipocytes. Which biological process, connected to the process ... | connective tissue development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00119","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRP5 is implicated in multiple biological processes. One specific connection is supported by evidence stating that LRP5 mutations and Wnt signaling l... | |
medium_divergent_branch_00120 | The gene CYP4F22 is enriched in multiple cell types. One specific cell type shows a mean expression of 11.60 TPM, a z-score of 2.69, and a fold enrichment of 13.44 for this gene. Which cell type does this specific cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00120","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CYP4F22 is enriched in multiple cell types. One specific cell type shows a mean expression of 11.60 TPM, a z-score of 2.69, and a fold enric... | |
medium_divergent_branch_00121 | The gene PKM is known to interact with multiple proteins. One specific interaction is supported by yeast two-hybrid studies demonstrating that a specific E3 ubiquitin-protein ligase interacts with PDH, PDK2, PDK4, the target protein (all participating in glycolysis), as well as phosphorylase beta (PYGM) and glycogenin.... | E3 ubiquitin-protein ligase TRIM63 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00121","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PKM is known to interact with multiple proteins. One specific interaction is supported by yeast two-hybrid studies demonstrating that a spec... | |
medium_divergent_branch_00122 | MIR92A1 is associated with multiple biological processes. One association is supported by evidence stating that 'Upregulation of miR-92a by oxLDL in atheroprone areas promotes endothelial activation and the development of atherosclerotic lesions.' Which biological process, connected to the process supported by this evi... | endothelial cell activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00122","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR92A1 is associated with multiple biological processes. One association is supported by evidence stating that 'Upregulation of miR-92a by oxLDL in ... | |
medium_divergent_branch_00123 | ASAP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Both coimmunoprecipitation and in vitro pulldown assays confirmed that ASAP1 directly binds to FIP3 through its BAR domain.' Which disease is associated with this specific interacting gene via a biomarker relationship? | spina bifida cystica | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00123","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ASAP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Both coimmunoprecipitation and in vitro pulldown assays confi... | |
medium_divergent_branch_00124 | NCKIPSD interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified a new mDia-interacting protein which is expressed ubiquitously.' Which protein, encoded by the gene connected to NCKIPSD via this specific interaction, is the subject of this evidence? | Protein diaphanous homolog 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00124","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCKIPSD interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified a new mDia-interacting protein which is ex... | |
medium_divergent_branch_00126 | CABIN1 interacts with multiple proteins. One specific interaction involves a partner protein that associates with the C-terminus of CABIN1 via its N-terminal domain and suppresses Mef2/CABIN1-mediated transcription. Which protein is encoded by the gene corresponding to this interacting partner? | Protein HIRA | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00126","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CABIN1 interacts with multiple proteins. One specific interaction involves a partner protein that associates with the C-terminus of CABIN1 via its N-... | |
medium_divergent_branch_00127 | MAP3K7 interacts with multiple proteins. One of these interactions is supported by evidence stating that the interacting protein and its downstream effector, a serine/threonine-protein kinase, associate with and activate TAK1. Which protein is encoded by the gene corresponding to this interacting partner? | Receptor-interacting serine/threonine-protein kinase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00127","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K7 interacts with multiple proteins. One of these interactions is supported by evidence stating that the interacting protein and its downstream e... | |
medium_divergent_branch_00128 | ARPC5 interacts with multiple proteins. One of these interaction partners is characterized by in vitro studies showing that it interacts with and phosphorylates the A isoform, but not the B isoform, of p16-Arc with a stoichiometry of 0.6 to 0.7. Which protein is encoded by the gene corresponding to this specific intera... | MAP kinase-activated protein kinase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00128","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARPC5 interacts with multiple proteins. One of these interaction partners is characterized by in vitro studies showing that it interacts with and pho... | |
medium_divergent_branch_00129 | hsa-miR-17-3p regulates more than one cell type. One line of evidence indicates that the miR-17-92 cluster facilitates the secretion of CXCL9 and CXCL10 from keratinocytes by inhibiting SOCS1, thereby enhancing chemotaxis for T lymphocytes. Which cell type, connected to hsa-miR-17-3p via a 'regulates' relationship, is ... | lymphocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00129","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-17-3p regulates more than one cell type. One line of evidence indicates that the miR-17-92 cluster facilitates the secretion of CXCL9 and CXC... | |
medium_divergent_branch_00130 | The gene PHC1 interacts with multiple partners. One specific interaction partner is supported by evidence showing that it coimmunoprecipitates with a human Polycomb (Pc) homolog, the vertebrate Polycomb group (PcG) protein BMI1, and HPH1, a human homolog of the PcG protein Polyhomeotic (Ph). Which protein is encoded by... | E3 ubiquitin-protein ligase RING1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00130","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PHC1 interacts with multiple partners. One specific interaction partner is supported by evidence showing that it coimmunoprecipitates with a... | |
medium_divergent_branch_00131 | NUP98 interacts with multiple genes. Evidence for one specific interaction states: 'We found that in vitro translated [Gene] bound to in vitro translated Nup98 and, via Nup98, to Nup96.' Which cell type is the gene identified by this evidence enriched in? | regulatory T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00131","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUP98 interacts with multiple genes. Evidence for one specific interaction states: 'We found that in vitro translated [Gene] bound to in vitro transl... | |
medium_divergent_branch_00132 | TRAF6 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: the interacting partner binds to TRAF6, enhances TRAF6 oligomerization, and thereby increases the E3 ligase activity of TRAF6 for the synthesis of K63-linked ubiquitin chains. Which protein corresponds to this ... | Palmitoyltransferase ZDHHC11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00132","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF6 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: the interacting partner binds to TRAF6,... | |
medium_divergent_branch_00133 | The biological process 'serotonin secretion by mast cell' is defined as the regulated release of serotonin by a mast cell or group of mast cells. This process is a subtype of a broader biological process. Which biological process is that broader process a part of? | exocytosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00133","source_qa_id":"medium_divergent_branch_00053","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'serotonin secretion by mast cell' is defined as the regulated release of ... | |
medium_divergent_branch_00134 | BRF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Pull-down assays and immunoprecipitations using recombinant components demonstrate that a subunit of TFIIIB interacts physically with p107 and a retinoblastoma family protein.' Which protein, encoded by the gene involved in this s... | Retinoblastoma-like protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00134","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Pull-down assays and immunoprecipitations using recombinant... | |
medium_divergent_branch_00135 | The gene LTA is associated with multiple proteins via binding interactions. One specific interaction involves a partner protein that co-assembles with LTalpha to form a membrane-anchored, heterotrimeric LTalpha1beta2 complex. This complex engages a distinct cognate receptor known as the LTbeta receptor (LTbetaR). Which... | Lymphotoxin-beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00135","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene LTA is associated with multiple proteins via binding interactions. One specific interaction involves a partner protein that co-assembles wit... | |
medium_divergent_branch_00136 | HLA-C interacts with multiple proteins. One interaction is characterized by the following evidence: 'The association of p105 is transient, while p78, which we identified as the immunoglobulin binding protein [REDACTED], interacts permanently with Cw3 alpha chains.' Which protein, connected to HLA-C via this specific in... | Endoplasmic reticulum chaperone BiP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00136","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HLA-C interacts with multiple proteins. One interaction is characterized by the following evidence: 'The association of p105 is transient, while p78,... | |
medium_divergent_branch_00137 | WAPL is associated with multiple cellular components via a 'located in' relationship. One of these associations is supported by evidence showing that depletion of WAPL increases the residence time of cohesin on that specific component during interphase. Which cellular component, connected to this identified component v... | chromosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00137","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WAPL is associated with multiple cellular components via a 'located in' relationship. One of these associations is supported by evidence showing that... | |
medium_divergent_branch_00138 | The gene IL2RA is enriched in multiple cell types. One specific cell type shows a mean expression of 248.16 TPM, a z-score of 2.33, and a fold enrichment of 19.06. Which broader cell lineage is this specific cell type a subtype of? | mature T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00138","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL2RA is enriched in multiple cell types. One specific cell type shows a mean expression of 248.16 TPM, a z-score of 2.33, and a fold enrich... | |
medium_divergent_branch_00139 | The gene RB1CC1 interacts with multiple partners. One specific interaction is part of a holo-complex studied via affinity purification and proximity labeling-mass spectrometry, which included the partner protein, ATG13, ATG101, and RB1CC1/FIP200. Which protein, encoded by the gene connected to RB1CC1 through this speci... | Serine/threonine-protein kinase ULK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00139","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RB1CC1 interacts with multiple partners. One specific interaction is part of a holo-complex studied via affinity purification and proximity ... | |
medium_divergent_branch_00141 | Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 2.018 and an adjusted p-value of 0.0381. Which disease has a genomic-alteration link with that selected gene? | breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00141","source_qa_id":"medium_divergent_branch_05790","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch ... | |
medium_divergent_branch_00142 | PIAS3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that a specific protein binds with PIAS (protein inhibitor of activated STAT) proteins, PIAS1, PIAS3, PIASxalpha and PIASy at their carboxyl-terminal region and is covalently modified by SUMO-1 (sumoylation).' Which prote... | Zinc finger protein RFP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00142","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIAS3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that a specific protein binds with PIAS (protein i... | |
medium_divergent_branch_00143 | IRF3 interacts with multiple proteins. One specific interaction partner is significantly induced and binds to IRF3 upon RNA virus infection. Which protein is this interaction partner? | E3 ubiquitin-protein ligase TRIM21 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00143","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRF3 interacts with multiple proteins. One specific interaction partner is significantly induced and binds to IRF3 upon RNA virus infection. Which pr... | |
medium_divergent_branch_00144 | The gene CRYAB interacts with multiple proteins. One interaction is supported by evidence that a heat shock protein, found in extracts of human and bovine tissues, co-eluted with alpha B crystallin from an affinity column prepared with antibodies against alpha B crystallin. Which protein is encoded by the gene connecte... | Heat shock protein beta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00144","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CRYAB interacts with multiple proteins. One interaction is supported by evidence that a heat shock protein, found in extracts of human and b... | |
medium_divergent_branch_00146 | PRPS1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The purified fusion protein had no PRPP synthetase activity, and bound to dissociated PRS I and PRS II, with a similar affinity.' Which protein, connected to PRPS1 via this specific interaction, is encoded by the gene in question... | Phosphoribosyl pyrophosphate synthase-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00146","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRPS1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The purified fusion protein had no PRPP synthetase activit... | |
medium_divergent_branch_00148 | The paraxial mesoderm is defined as the mesoderm located bilaterally adjacent to the notochord and neural tube. This structure is a subtype of a specific anatomical entity. Which anatomical entity is the paraxial mesoderm a subtype of? | mesenchyme | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00148","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The paraxial mesoderm is defined as the mesoderm located bilaterally adjacent to the notochord and neural tube. This structure is a subtype of a spec... | |
medium_divergent_branch_00149 | RPS6KB1 interacts with multiple genes. One specific interaction is supported by the evidence: 'We demonstrate for the first time that CoA synthase associates specifically with S6K1.' Which biological process is the gene identified in this evidence involved in? | coenzyme A biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00149","source_qa_id":"medium_divergent_branch_04624","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RPS6KB1 interacts with multiple genes. One specific interaction is supported by the evidence: 'We... | |
medium_divergent_branch_00150 | Plakophilin-3 (PKP3) is associated with multiple cellular components via localization. One specific association is supported by evidence stating that a decrease in the levels of the desmosomal plaque protein, plakophilin-3, leads to a decrease in the size of that specific structure and in cell-cell adhesion. Which cell... | cell-cell junction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00150","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Plakophilin-3 (PKP3) is associated with multiple cellular components via localization. One specific association is supported by evidence stating that... | |
medium_divergent_branch_00151 | MCM7 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified minichromosome maintenance 7, an essential component of the pre-replication complex, as a novel Smc1-interacting protein.' Which protein, connected to MCM7 via this specific interaction, is the subject of the 'encode... | Structural maintenance of chromosomes protein 1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00151","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCM7 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified minichromosome maintenance 7, an essential co... | |
medium_divergent_branch_00152 | GNAZ interacts with multiple proteins. One interaction is supported by evidence stating: 'In an ongoing effort to elucidate the role of Gzalpha in cell signaling, the yeast two-hybrid system was employed to identify proteins that could interact with a mutationally activated form of Gzalpha.' Which protein product is en... | Regulator of G-protein signaling 20 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00152","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNAZ interacts with multiple proteins. One interaction is supported by evidence stating: 'In an ongoing effort to elucidate the role of Gzalpha in ce... | |
medium_divergent_branch_00153 | FIS1 interacts with multiple proteins. One reported interaction list identifies six proteins that interact with a specific entity: TLE1, GALNT2, HTATIP, Vimentin, FIS1, and PPP2R5E. Which protein from this list is the entity that interacts with FIS1, and what protein does the gene for this entity encode? | Nucleotide-binding oligomerization domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00153","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FIS1 interacts with multiple proteins. One reported interaction list identifies six proteins that interact with a specific entity: TLE1, GALNT2, HTAT... | |
medium_divergent_branch_00154 | The gene CHAF1A interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Furthermore, we demonstrate that hAsf1 proteins can interact directly with the p60 subunit of hCAF-1.' Which protein is encoded by the gene that interacts with CHAF1A in this specific context? | Histone chaperone ASF1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00154","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CHAF1A interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Furthermore, we demonstrate that hAs... | |
medium_divergent_branch_00155 | hsa-miR-582-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'Our results demonstrated that miR-582-5p and miR-590-5p play important roles in opioid-induced immunosuppression in monocytes by targeting CREB1/CREB5-NF-κB signaling pathway.' Which cell type, connected to hsa-m... | promonocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00155","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-582-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'Our results demonstrated that miR-582-5p ... | |
medium_divergent_branch_00156 | MSH3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we show that each subunit of the human 9-1-1 complex physically interacts with hMSH2, hMSH3, and hMSH6.' Which protein, encoded by the gene connected to MSH3 via this specific interaction, is the target of the 'enco... | Cell cycle checkpoint protein RAD1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00156","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MSH3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we show that each subunit of the human 9-1-1... | |
medium_divergent_branch_00157 | ABCB1 interacts with multiple proteins. One of these interacting partners was identified via chromatin immunoprecipitation alongside TFIID, and electrophoretic mobility shift assays confirmed that this partner binds preferentially to an Sp-target site (GC-box) on the MDR1 promoter in brain endothelium. Which protein is... | Transcription factor Sp3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00157","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCB1 interacts with multiple proteins. One of these interacting partners was identified via chromatin immunoprecipitation alongside TFIID, and elect... | |
medium_divergent_branch_00159 | MKRN2 interacts with multiple proteins. One interaction is supported by evidence stating: 'The resulting protein-interaction network reveals interactions between the RNA-binding E3 ubiquitin ligase MKRN2 and a DEAD-box helicase activator implicated in mRNA export termination.' What is the name of the protein encoded by... | mRNA export factor GLE1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00159","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MKRN2 interacts with multiple proteins. One interaction is supported by evidence stating: 'The resulting protein-interaction network reveals interact... | |
medium_divergent_branch_00160 | RPP30 interacts with multiple proteins. One of these interaction partners has been reported to have a unique association with 7 of the 10 protein subunits of the RNase P complex, an endonuclease responsible for tRNA 5' maturation. Which protein, connected to RPP30 via an interaction, is the subject of this specific fin... | MOB kinase activator 3C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00160","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPP30 interacts with multiple proteins. One of these interaction partners has been reported to have a unique association with 7 of the 10 protein sub... | |
medium_divergent_branch_00161 | BIN1 interacts with multiple genes. One of these interaction partners was identified as a novel binding partner of BIN1, both in vitro and endogenously in skeletal muscle. Which gene, connected to BIN1 through this specific interaction, is the subject of this evidence? | MTMR12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00161","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIN1 interacts with multiple genes. One of these interaction partners was identified as a novel binding partner of BIN1, both in vitro and endogenous... | |
medium_divergent_branch_00162 | Type B synovial cells are classified under two distinct parent categories. One of these categories is defined by a resident cell type located in the synovial membrane that is responsible for the production of immune-related cytokines and chemokines. This specific cell type secretes glycoproteins and hyaluronic acid, po... | connective tissue cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00162","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Type B synovial cells are classified under two distinct parent categories. One of these categories is defined by a resident cell type located in the ... | |
medium_divergent_branch_00163 | PDPK1 interacts with multiple genes. One interaction is supported by evidence stating: 'Thereafter, PDK1 stably interacted with 14-3-3ε and was dephosphorylated;'. Which cell type is enriched in the gene corresponding to this specific interaction? | conventional dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00163","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDPK1 interacts with multiple genes. One interaction is supported by evidence stating: 'Thereafter, PDK1 stably interacted with 14-3-3ε and was depho... | |
medium_divergent_branch_00165 | The gene CHM is known to interact with multiple other genes via protein-protein binding. One specific interaction is supported by evidence describing the in vitro assembly, purification, and crystallization of the monoprenylated Rab7GDP:REP-1 complex. Which protein is encoded by the gene that binds to CHM in this speci... | Ras-related protein Rab-7a | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00165","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CHM is known to interact with multiple other genes via protein-protein binding. One specific interaction is supported by evidence describing... | |
medium_divergent_branch_00166 | The biological process 'protein transport' is a subtype of two distinct higher-level processes. One of these parent processes is defined by the evidence: 'The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.' Which biological process is... | establishment of localization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00166","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process 'protein transport' is a subtype of two distinct higher-level processes. One of these parent processes is defined by the evide... | |
medium_divergent_branch_00167 | CCNB1 interacts with multiple genes. One specific interaction was identified using a yeast two-hybrid screen to find proteins potentially mediating the localization of cyclin B1, revealing a novel interaction between cyclin B1 and a partner protein. Which disease is associated with the gene identified in this specific ... | frontotemporal dementia and/or amyotrophic lateral sclerosis 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00167","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCNB1 interacts with multiple genes. One specific interaction was identified using a yeast two-hybrid screen to find proteins potentially mediating t... | |
medium_divergent_branch_00168 | ERCC4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies show that alphaSpIISigma*, FANCA and XPF co-immunoprecipitate with each other from normal human nuclear proteins.' Which protein, connected to ERCC4 via this specific interaction evidence, is the ge... | Spectrin alpha chain, erythrocytic 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00168","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies show that alphaSpIISigma*, ... | |
medium_divergent_branch_00169 | UBE2E1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using in vitro E3 assays and yeast two-hybrid screens, we found that Ube2d, Ube2e families, Ube2n/2v1, and Ube2w catalyze autoubiquitination of the [protein] and Ube2d2, [protein], and Ube 2n/2v1 catalyze [protein]-mediated subs... | E3 ubiquitin-protein ligase CBL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00169","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2E1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using in vitro E3 assays and yeast two-hybrid screens, we... | |
medium_divergent_branch_00170 | RPP40 interacts with multiple proteins. One of these interaction partners has been reported to have a unique association with 7 of the 10 protein subunits of the RNase P complex, an endonuclease responsible for tRNA 5' maturation. Which protein, connected to RPP40 via an interaction, is the subject of this specific evi... | MOB kinase activator 3C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00170","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPP40 interacts with multiple proteins. One of these interaction partners has been reported to have a unique association with 7 of the 10 protein sub... | |
medium_divergent_branch_00171 | SETD2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Coimmunoprecipitation assays indicate that HYPB protein associates with hyperphosphorylated RNA polymerase II (RNAPII) but not the unphosphorylated form.' Which protein, encoded by the gene connected to SETD2 via this specific in... | DNA-directed RNA polymerase II subunit RPB1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00171","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SETD2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Coimmunoprecipitation assays indicate that HYPB protein as... | |
medium_divergent_branch_00172 | The gene TFAP2A is reported to interact with multiple partners. One specific interaction is supported by evidence stating: 'Ku proteins were identified as AP-2alpha interacting proteins by glutathione serine transferase (GST)-pull down followed by mass spectrometry.' Which protein is encoded by the gene linked to TFAP2... | DNA repair protein Ku80 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00172","source_qa_id":"medium_divergent_branch_02863","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene TFAP2A is reported to interact with multiple partners. One specific interaction is suppo... | |
medium_divergent_branch_00174 | Otic fibrocytes are anatomically connected to a specific structure via a 'part of' relationship. Evidence for this connection describes the structure as a spiral thickening of the fibrous lining of the cochlear wall that secures the membranous cochlear duct to the bony spiral canal. Furthermore, the fibrocytes within t... | cochlear duct of membranous labyrinth | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00174","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Otic fibrocytes are anatomically connected to a specific structure via a 'part of' relationship. Evidence for this connection describes the structure... | |
medium_divergent_branch_00175 | STAM2 interacts with multiple genes. One interaction is supported by evidence stating: 'A protein tyrosine phosphatase binds ESCRT-0 via two interactions with the STAM2 subunit.' Which disease is associated with the gene that interacts with STAM2 in this specific context? | neurodevelopmental disorder and structural brain anomalies with or without seizures and spasticity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00175","source_qa_id":"medium_divergent_branch_05394","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"STAM2 interacts with multiple genes. One interaction is supported by evidence stating: 'A protein... | |
medium_divergent_branch_00176 | CASP3 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that, under physiologically relevant conditions, caspase 3, but not caspase 7, can cleave the interacting partner, and this does not result in the activation of the interacting partner.' Which disease is associated with the ... | mantle cell lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00176","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CASP3 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that, under physiologically relevant conditions, casp... | |
medium_divergent_branch_00177 | LRG1 is associated with multiple biological processes via the 'involved in' relationship. One of these associations is supported by evidence stating that LRG1 deletion leads to impaired immune cell infiltration, reepithelialization, and angiogenesis. Which cell type is linked to this specific biological process through... | dendritic epidermal T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00177","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRG1 is associated with multiple biological processes via the 'involved in' relationship. One of these associations is supported by evidence stating ... | |
medium_divergent_branch_00178 | IBTK interacts with multiple genes. One of these interaction partners is identified in experimental evidence as a tumor suppressor that serves as an interactor and ubiquitylation substrate of CRL3(IBTK) for proteasomal degradation. Which disease is associated with this specific interacting gene via a biomarker relation... | adenoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00178","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IBTK interacts with multiple genes. One of these interaction partners is identified in experimental evidence as a tumor suppressor that serves as an ... | |
medium_divergent_branch_00179 | SP1 interacts with multiple proteins. One of these interaction partners shares a specific structural feature: the same region of this protein that binds to SP1 in solution also binds to SREBP. Which protein is encoded by the gene corresponding to this interaction partner? | Transcriptional repressor protein YY1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00179","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SP1 interacts with multiple proteins. One of these interaction partners shares a specific structural feature: the same region of this protein that bi... | |
medium_divergent_branch_00180 | The gene ACTR2 interacts with multiple partners. One specific interaction is supported by evidence from an unbiased BioID screen that identified members of the Arp2/3 complex and confirmed a physical and functional interaction between the partner gene and Arp2 in mediating partner-driven cancer cell movement. Which dis... | Seckel syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00180","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACTR2 interacts with multiple partners. One specific interaction is supported by evidence from an unbiased BioID screen that identified memb... | |
medium_divergent_branch_00181 | The gene ILK interacts with multiple partners via binding. One specific interaction is supported by evidence describing a new LIM-domain containing protein that forms a complex with the interacting partner. Which disease is associated with this specific interacting partner? | autosomal recessive limb-girdle muscular dystrophy type 2W | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00181","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ILK interacts with multiple partners via binding. One specific interaction is supported by evidence describing a new LIM-domain containing p... | |
medium_divergent_branch_00182 | TIMP1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'In addition, TIMP-1 binding to this protein activated β1 integrin-mediated signalling through Akt and FAK phosphorylation, leading to pattern changes in distribution of vinculin and F-actin (filamentous actin).... | CD63 antigen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00182","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TIMP1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'In addition, TIMP-1 binding to this pro... | |
medium_divergent_branch_00183 | XAF1 interacts with multiple proteins. One interaction is characterized by the partner protein promoting the ubiquitination and degradation of XAF1. Which protein, connected to XAF1 via this specific interaction, is encoded by the gene in question? | E3 ubiquitin-protein ligase TRIM47 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00183","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"XAF1 interacts with multiple proteins. One interaction is characterized by the partner protein promoting the ubiquitination and degradation of XAF1. ... | |
medium_divergent_branch_00184 | LRWD1 interacts with multiple genes. One of these interaction partners is described in evidence stating: 'We demonstrate that ORCA associates with the E3 ubiquitin ligase Cul4A-Ddb1.' Which disease is associated with this specific interaction partner? | Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00184","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRWD1 interacts with multiple genes. One of these interaction partners is described in evidence stating: 'We demonstrate that ORCA associates with th... | |
medium_divergent_branch_00185 | L1CAM is associated with multiple biological processes. One association is supported by evidence stating: 'The mutant-expressing cells, defective in adhesion to extracellular matrix proteins and in migration, exhibited unchanged proliferation.' Which biological process is a parent term (via 'is a') of the process descr... | cell motility | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00185","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"L1CAM is associated with multiple biological processes. One association is supported by evidence stating: 'The mutant-expressing cells, defective in ... | |
medium_divergent_branch_00186 | GATA4 interacts with multiple genes. One specific interaction is characterized by a physical synergy observed both in vitro and in vivo, mapping to the C-terminal zinc finger of GATA4 and a C-terminus extension; similarly, a C-terminally extended homeodomain of the interacting partner is required for GATA4 binding. Whi... | myotonic dystrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00186","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA4 interacts with multiple genes. One specific interaction is characterized by a physical synergy observed both in vitro and in vivo, mapping to t... | |
medium_divergent_branch_00187 | The gene FANCC interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We identified the molecular chaperone Hsp70 as an interacting partner of FANCC in lymphoblasts and HeLa cells using pull-down and co-immunoprecipitation experiments.' Which protein, encoded by the gene connected... | Heat shock cognate 71 kDa protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00187","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FANCC interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We identified the molecular chaperone Hs... | |
medium_divergent_branch_00188 | TRIM29 interacts with multiple genes. One of these interaction partners is described as an E3 ubiquitin ligase and DNA damage response protein that physically interacts with ATDC, a requirement for ATDC-induced radioresistance. Which disease is associated with this specific interaction partner via a biomarker relations... | Fanconi anemia complementation group A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00188","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM29 interacts with multiple genes. One of these interaction partners is described as an E3 ubiquitin ligase and DNA damage response protein that p... | |
medium_divergent_branch_00189 | LAMTOR3 interacts with multiple genes. One interaction involves a complex encoded by MAPKSP1, ROBLD3, and c11orf59 (termed Ragulator), which interacts with Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation. Which disease is associated with the gene that is part of this specific Ragulator-R... | Long-Olsen-Distelmaier syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00189","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LAMTOR3 interacts with multiple genes. One interaction involves a complex encoded by MAPKSP1, ROBLD3, and c11orf59 (termed Ragulator), which interact... | |
medium_divergent_branch_00190 | The bony part of the pharyngotympanic tube is structurally related to a specific anatomical category. Evidence for this relationship describes the entity as being approximately 12 mm in length, beginning in the carotid wall of the tympanic cavity below the septum canalis musculotubarii, and ending at the junction of th... | bone element | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00190","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The bony part of the pharyngotympanic tube is structurally related to a specific anatomical category. Evidence for this relationship describes the en... | |
medium_divergent_branch_00191 | BMP4 interacts with multiple proteins. One documented interaction involves BMP-4 binding to ALK-3 in MC3T3-E1 osteoblasts and human foreskin fibroblasts. Which protein, encoded by the gene involved in this specific binding event, is the target of the 'encodes' relationship? | Bone morphogenetic protein receptor type-1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00191","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMP4 interacts with multiple proteins. One documented interaction involves BMP-4 binding to ALK-3 in MC3T3-E1 osteoblasts and human foreskin fibrobla... | |
medium_divergent_branch_00192 | WTIP interacts with multiple proteins. One interaction is supported by evidence stating: 'In mammalian and Drosophila cells, Ajuba LIM proteins/dJub interact with LATS/Warts (Wts) and WW45/Sav to inhibit phosphorylation of YAP/Yki.' Which protein, connected to WTIP via this specific interaction evidence, is the gene th... | Serine/threonine-protein kinase LATS2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00192","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WTIP interacts with multiple proteins. One interaction is supported by evidence stating: 'In mammalian and Drosophila cells, Ajuba LIM proteins/dJub ... | |
medium_divergent_branch_00193 | DAB2 interacts with multiple genes. One interaction is supported by evidence stating: 'Using a small-pool cDNA screening strategy, we identify that the N-terminal domain of Dab2 interacts with Dishevelled-3 (Dvl-3), a signaling mediator of the Wnt pathway.' Which disease is connected to this specific interacting gene t... | pneumocystosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00193","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAB2 interacts with multiple genes. One interaction is supported by evidence stating: 'Using a small-pool cDNA screening strategy, we identify that t... | |
medium_divergent_branch_00194 | OS9 interacts with multiple proteins. One interaction partner is involved in the degradation of the ERAD substrate mutant alpha(1)-antitrypsin, a process requiring the ER chaperone GRP94 along with Hrd1 and SEL1L. Which protein is encoded by the gene corresponding to this specific interaction partner? | Endoplasmic reticulum chaperone BiP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00194","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OS9 interacts with multiple proteins. One interaction partner is involved in the degradation of the ERAD substrate mutant alpha(1)-antitrypsin, a pro... | |
medium_divergent_branch_00195 | NDC80 is known to bind to multiple gene products. One specific interaction is supported by evidence stating: 'We used AlphaFold 2 (AF2) to obtain predictions of the Ndc80 'loop' structure and of the Ndc80 : [Partner] globular head domains that interact with the Dam1 subunit of the heterodecameric DASH/Dam1 complex (Dam... | RABGAP1L | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00195","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NDC80 is known to bind to multiple gene products. One specific interaction is supported by evidence stating: 'We used AlphaFold 2 (AF2) to obtain pre... | |
medium_divergent_branch_00196 | Caffeine interacts with multiple drugs. One of these interacting drugs was the subject of a clinical study alongside caffeine, which suggested that this drug (referred to as OCA) may serve as a useful positive control for establishing a method to evaluate CYP1A2 downregulation. What disease is this specific drug indica... | primary biliary cholangitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00196","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Caffeine interacts with multiple drugs. One of these interacting drugs was the subject of a clinical study alongside caffeine, which suggested that t... | |
medium_divergent_branch_00197 | JUP (junction plakoglobin) interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we identified γ-catenin as a new binding protein of [Gene:FBXW7] by TAP-MS (tandem affinity purification-mass spectrum).' Which protein is encoded by the gene that interacts with JUP and is ide... | F-box/WD repeat-containing protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00197","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JUP (junction plakoglobin) interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we identified γ-cateni... | |
medium_divergent_branch_00198 | The DRD2 gene interacts with multiple partners. One specific interaction involves a protein described as 'Spinophilin, a recently characterized F-actin and protein phosphatase-1-binding protein with a single PDZ domain' that specifically associates with D2 receptors. Which protein is encoded by the gene corresponding t... | Neurabin-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00198","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The DRD2 gene interacts with multiple partners. One specific interaction involves a protein described as 'Spinophilin, a recently characterized F-act... | |
medium_divergent_branch_00199 | The pituitary gland consists of multiple anatomical components. One of these components is described as an endocrine gland located ventral to the diencephalon, derived from mixed neuroectodermal and non-neuroectodermal origins. Which anatomical structure, connected to the pituitary gland via a 'has part' relationship, ... | neurectoderm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00199","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The pituitary gland consists of multiple anatomical components. One of these components is described as an endocrine gland located ventral to the die... | |
medium_divergent_branch_00200 | PIK3R1 interacts with multiple genes. One of these interacting partners contains a pro-4/pro-5 motif that binds in vitro particularly well to the Src, p85 alpha PI3-kinase, and Eps8 SH3 domains expressed as GST fusion proteins. Which disease is associated with this specific interacting gene via a biomarker relationship... | melanoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00200","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIK3R1 interacts with multiple genes. One of these interacting partners contains a pro-4/pro-5 motif that binds in vitro particularly well to the Src... | |
medium_divergent_branch_00201 | The transcription factor PROX1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Its absence from bile duct epithelial cells suggests a function for the specification of hepatoblasts into hepatocytes.' Identify the broader biological process that encompasses t... | liver development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00201","source_qa_id":"medium_divergent_branch_00596","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The transcription factor PROX1 is associated with multiple biological processes. One specific ass... | |
medium_divergent_branch_00203 | BIRC2 interacts with multiple genes. One of these interaction partners is identified in the literature as a c-IAP-associated deubiquitinating enzyme that regulates c-IAP1 stability. Which cellular component is this specific interaction partner located in? | extracellular exosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00203","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIRC2 interacts with multiple genes. One of these interaction partners is identified in the literature as a c-IAP-associated deubiquitinating enzyme ... | |
medium_divergent_branch_00204 | DOK1 interacts with multiple genes. One of these interaction partners is described in a study stating: 'We now report that this protein associates with DOK1, a protein that interacts with Ras-GAP, Csk, and Nck.' Which disease is associated with this specific interaction partner? | X-linked lymphoproliferative disease due to SH2D1A deficiency | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00204","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DOK1 interacts with multiple genes. One of these interaction partners is described in a study stating: 'We now report that this protein associates wi... | |
medium_divergent_branch_00205 | Ammon's horn is anatomically connected to two distinct higher-order structures via 'part of' relationships. One of these connections is supported by evidence describing a structure as a part of the brain consisting of a three-layered cortex located in the forebrain, bordering the medial surface of the lateral ventricle... | regional part of brain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00205","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Ammon's horn is anatomically connected to two distinct higher-order structures via 'part of' relationships. One of these connections is supported by ... | |
medium_divergent_branch_00206 | NPFFR1 is associated with multiple molecular functions. One association is supported by evidence stating: 'Two G protein-coupled receptors, NPFF1 and NPFF2, were isolated from human and rat central nervous system tissues.' Identify the biological process that is a parent of the molecular function supported by this spec... | G protein-coupled receptor signaling pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00206","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NPFFR1 is associated with multiple molecular functions. One association is supported by evidence stating: 'Two G protein-coupled receptors, NPFF1 and... | |
medium_divergent_branch_00208 | NUP107 is associated with multiple biological processes. One association is supported by evidence stating: 'These results indicate a pivotal role for NUP107 in ovarian development.' Which biological process is a parent term (via 'is a') of the process linked to NUP107 by this specific evidence? | gonad development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00208","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUP107 is associated with multiple biological processes. One association is supported by evidence stating: 'These results indicate a pivotal role for... | |
medium_divergent_branch_00209 | MAP2K4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation experiments indicated that PP2Cepsilon associates stably with a protein kinase and attenuates the binding of that protein kinase to MKK4 or MKK6.' Which protein, connected to MAP2K4 via this specific inter... | Mitogen-activated protein kinase kinase kinase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00209","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP2K4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation experiments indicated that PP2Ceps... | |
medium_divergent_branch_00210 | USP37 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we demonstrate that the deubiquitinating enzyme USP37 interacts with this gene and that USP37 deubiquitinates and stabilizes this gene, thereby sustaining the DNA damage response (DDR).' Which disease is associated wi... | adrenal gland neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00210","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP37 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we demonstrate that the deubiquitinating enzym... | |
medium_divergent_branch_00211 | The midbrain is defined as the middle division of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain in vertebrates. This structure includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina, and it surrounds ... | regional part of nervous system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00211","source_qa_id":"medium_divergent_branch_02840","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The midbrain is defined as the middle division of the three primary divisions of the developing c... | |
medium_divergent_branch_00212 | ATG14 interacts with multiple genes. One of these interaction partners is described in a study investigating the mechanism by which it regulates autophagy, demonstrating that it interacts and colocalizes with ATG14L, suggesting it is a component of the ATG14L-containing Beclin 1-Vps34 complex. Which cellular component ... | phosphatidylinositol 3-kinase complex, class III | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00212","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATG14 interacts with multiple genes. One of these interaction partners is described in a study investigating the mechanism by which it regulates auto... | |
medium_divergent_branch_00213 | DSCAML1 is associated with multiple biological processes. One association is supported by evidence stating: 'We propose that the DSCAMs comprise novel elements of the pathways mediating dorsal-ventral patterning and cell-fate specification in the developing CNS.' Which anatomical structure is the result of the developm... | central nervous system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00213","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DSCAML1 is associated with multiple biological processes. One association is supported by evidence stating: 'We propose that the DSCAMs comprise nove... | |
medium_divergent_branch_00214 | IL1R1 interacts with multiple proteins. One of these interaction partners is reported to coimmunoprecipitate with the IL-1R signaling complex in an IL-1-dependent manner. Which protein corresponds to this interaction partner? | Myeloid differentiation primary response protein MyD88 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00214","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL1R1 interacts with multiple proteins. One of these interaction partners is reported to coimmunoprecipitate with the IL-1R signaling complex in an I... |
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