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medium_divergent_branch_00216 | STAT3 interacts with multiple genes. Evidence for one specific interaction states: 'The interaction between this gene and signal transducer and activator of transcription 3 (STAT3) controlled the gene-mediated increase in Snail2 expression and cellular invasion, which were specifically abrogated using the STAT3 inhibit... | intellectual developmental disorder, autosomal recessive 67 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00216","source_qa_id":"medium_divergent_branch_01709","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"STAT3 interacts with multiple genes. Evidence for one specific interaction states: 'The interacti... | |
medium_divergent_branch_00217 | PLXNB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that Plexin B2 associates directly with two members of a recently identified family of Dbl homology/pleckstrin homology containing guanine nucleotide exchange factors for Rho, [Protein A], and Leukemia-associated Rh... | Rho guanine nucleotide exchange factor 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00217","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLXNB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that Plexin B2 associates directly with two ... | |
medium_divergent_branch_00218 | MAP1LC3B interacts with multiple proteins. One specific interaction partner is described as interacting with ubiquitinated proteins and the autophagic marker light chain 3b (LC3b), thereby mediating the degradation of selective targets. Which protein product is encoded by the gene corresponding to this specific interac... | Sequestosome-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00218","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP1LC3B interacts with multiple proteins. One specific interaction partner is described as interacting with ubiquitinated proteins and the autophagi... | |
medium_divergent_branch_00219 | NUP98 interacts with multiple proteins. One specific interaction involves a protein described as the mammalian homologue of Gle2p, which binds to a GLEBS-like motif on NUP98 at the nuclear pore complex through domains including WD-repeats and a COOH-terminal non-WD-repeat extension. Which protein, connected to NUP98 vi... | mRNA export factor RAE1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00219","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUP98 interacts with multiple proteins. One specific interaction involves a protein described as the mammalian homologue of Gle2p, which binds to a G... | |
medium_divergent_branch_00220 | APEX1 is known to physically interact with multiple proteins. One specific interaction is described as follows: 'We find that human AP endonuclease 1 (APE1) physically interacts with flap endonuclease 1 and with proliferating cell nuclear antigen.' Based on this description, identify the protein that interacts with APE... | lung cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00220","source_qa_id":"medium_divergent_branch_07131","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"APEX1 is known to physically interact with multiple proteins. One specific interaction is describ... | |
medium_divergent_branch_00222 | Mindbomb 1 (MIB1) interacts with multiple proteins. One interaction is supported by evidence stating: 'We discovered that the interacting partner both physically and functionally interacts with the E3 ubiquitin ligase Mindbomb 1 (MIB1).' Which protein corresponds to this specific interaction evidence, and what is the n... | Tyrosine-protein kinase RYK | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00222","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Mindbomb 1 (MIB1) interacts with multiple proteins. One interaction is supported by evidence stating: 'We discovered that the interacting partner bot... | |
medium_divergent_branch_00223 | VANGL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Mutagenesis studies identified a YYXXF sorting signal in the C-terminal cytosolic domain of VANGL2 that is required for VANGL2 traffic and interaction with the μ subunit of AP-1.' Which protein, connected to VANGL2 via this spec... | AP-1 complex subunit mu-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00223","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VANGL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Mutagenesis studies identified a YYXXF sorting signal in ... | |
medium_divergent_branch_00224 | KIF5B interacts with multiple proteins. One interaction is supported by evidence stating: 'The major binding site for kinesin light chain in kinesin heavy chain was mapped to residues 789-813 at the C-terminal end of the heavy chain stalk domain.' Which protein, encoded by the gene interacting with KIF5B in this specif... | Kinesin light chain 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00224","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF5B interacts with multiple proteins. One interaction is supported by evidence stating: 'The major binding site for kinesin light chain in kinesin ... | |
medium_divergent_branch_00225 | DICER1 is reported to interact with multiple genes. One specific interaction is supported by evidence stating: 'Here, we demonstrate the ability of Dicer C-terminus to interact with 5-lipoxygenase (5LO), an enzyme involved in the biosynthesis of inflammatory mediators, in vitro and in cultured human cells.' Which gene,... | GRB2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00225","source_qa_id":"medium_divergent_branch_03792","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"DICER1 is reported to interact with multiple genes. One specific interaction is supported by evid... | |
medium_divergent_branch_00226 | HIST1H2BB interacts with multiple proteins. One of these interacting partners has been shown to monoubiquitinate H2BK120 in vitro using its purified PHD finger or full-length form, and its loss significantly reduces genome-wide H2BK120Ub binding sites in MCF10A cells. Which protein, connected to HIST1H2BB via an intera... | Putative E3 ubiquitin-protein ligase UBR7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00226","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIST1H2BB interacts with multiple proteins. One of these interacting partners has been shown to monoubiquitinate H2BK120 in vitro using its purified ... | |
medium_divergent_branch_00227 | The gene CTNS is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating: 'The protein sequence contains at least two signals that target the protein to the lysosomal compartment, one of which is located at the carboxy terminal tail (GYDQL).... | lytic vacuole | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00227","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CTNS is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stati... | |
medium_divergent_branch_00228 | CD74 is involved in multiple biological processes. One of these processes is supported by evidence stating that CD74 is required for MIF-induced activation of the extracellular signal-regulated kinase-1/2 MAP kinase cascade. Which biological process is positively regulated by this specific CD74-associated process? | cytokine-mediated signaling pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00228","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD74 is involved in multiple biological processes. One of these processes is supported by evidence stating that CD74 is required for MIF-induced acti... | |
medium_divergent_branch_00229 | KRT18 interacts with multiple keratin partners. One specific interaction is supported by evidence stating: 'The explanation does not appear to reside in an inability of K18 to form 10-nm filaments with K5, which it does in vitro and in vivo.' Identify the biological process associated with the partner gene mentioned in... | epidermis development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00229","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KRT18 interacts with multiple keratin partners. One specific interaction is supported by evidence stating: 'The explanation does not appear to reside... | |
medium_divergent_branch_00230 | STX1A interacts with multiple proteins. One interaction is supported by evidence stating: 'We find that alpha-SNAP binds directly to syntaxin 1A as well as weakly to SNAP-25, while it does not bind to synaptobrevin II.' Which protein, encoded by the gene interacting with STX1A in this specific context, is the subject o... | Alpha-soluble NSF attachment protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00230","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX1A interacts with multiple proteins. One interaction is supported by evidence stating: 'We find that alpha-SNAP binds directly to syntaxin 1A as w... | |
medium_divergent_branch_00231 | BCL3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Herein, we show that a distinct IkappaB protein Bcl3 also interacts with RXR, as shown in the yeast two-hybrid tests and glutathione S-transferase pull-down assays.' Which protein, connected to BCL3 via this interaction, ... | Retinoic acid receptor RXR-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00231","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Herein, we show that a distinct IkappaB protein Bc... | |
medium_divergent_branch_00232 | EGR1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using the yeast two-hybrid system, we have isolated a cDNA clone which encodes a protein that interacts with this inhibitory domain and inhibits the ability of NGFI-A to activate transcription.' Which protein, connected t... | NGFI-A-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00232","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EGR1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using the yeast two-hybrid system, we have isolate... | |
medium_divergent_branch_00235 | BMPR1A interacts with multiple genes. One of these interactors is identified in the following evidence as a deubiquitylating enzyme that also interacts with SMAD6 and ALK3: 'Here, we identify a deubiquitylating enzyme as an interactor of SMAD6 and ALK3.' Which disease is associated with this gene via a biomarker relati... | Moyamoya disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00235","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMPR1A interacts with multiple genes. One of these interactors is identified in the following evidence as a deubiquitylating enzyme that also interac... | |
medium_divergent_branch_00236 | TRIM21 interacts with multiple genes. One specific interaction is characterized by evidence showing that TRIM21 mediates the ubiquitination and proteasome-dependent degradation of the interacting partner, resulting in a negative correlation with the partner's levels and a reverse regulation of its tumorigenic activity ... | MICAL-like protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00236","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM21 interacts with multiple genes. One specific interaction is characterized by evidence showing that TRIM21 mediates the ubiquitination and prote... | |
medium_divergent_branch_00237 | The gene SH3BGRL is enriched in multiple cell types. One specific cell type shows a mean expression of 660.47 TPM, a z-score of 1.73, and a fold enrichment of 2.45. Which broader cell lineage is this specific cell type a subtype of? | monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00237","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SH3BGRL is enriched in multiple cell types. One specific cell type shows a mean expression of 660.47 TPM, a z-score of 1.73, and a fold enri... | |
medium_divergent_branch_00238 | SOX6 interacts with multiple proteins. One of these interacting partners is a HECT domain E3 ubiquitin ligase that has been shown to recognize and polyubiquitinate SOX6. Which protein, encoded by the gene corresponding to this specific interacting partner, is connected to SOX6? | E3 ubiquitin-protein ligase TRIP12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00238","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX6 interacts with multiple proteins. One of these interacting partners is a HECT domain E3 ubiquitin ligase that has been shown to recognize and po... | |
medium_divergent_branch_00240 | CNTFR is associated with multiple biological processes. One association is supported by evidence stating that CNTFR alpha is critical for the developing nervous system, likely by serving as a receptor for a developmentally important CNTF-like ligand. Which biological process, connected to the process supported by this ... | system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00240","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNTFR is associated with multiple biological processes. One association is supported by evidence stating that CNTFR alpha is critical for the develop... | |
medium_divergent_branch_00244 | ARHGDIG interacts with multiple proteins. One specific interaction partner is characterized by binding to CDC42 and itself with lower affinity compared to RhoGDI, while showing no binding to Rac1, Rac2, or Ras. Which disease is associated with this specific interaction partner via a biomarker relationship? | alopecia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00244","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARHGDIG interacts with multiple proteins. One specific interaction partner is characterized by binding to CDC42 and itself with lower affinity compar... | |
medium_divergent_branch_00245 | mmu-miR-126 regulates more than one type of cell. One specific regulatory interaction is supported by evidence stating: 'Furthermore, miR-126 silencing could obviously reduce the expression of Foxp3 on Tregs, which was accompanied by decreased expression of CTLA-4 and GITR, as well as IL-10 and TGF-β, and impair its su... | mature T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00245","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-126 regulates more than one type of cell. One specific regulatory interaction is supported by evidence stating: 'Furthermore, miR-126 silenci... | |
medium_divergent_branch_00246 | UBE2E3 interacts with multiple genes. One interaction is supported by evidence that a transcription factor and UbcM2 form a complex upon alkylation of a non-catalytic cysteine in UbcM2 (Cys-136). Which disease is associated with the gene identified by this evidence? | immunodeficiency, developmental delay, and hypohomocysteinemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00246","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2E3 interacts with multiple genes. One interaction is supported by evidence that a transcription factor and UbcM2 form a complex upon alkylation o... | |
medium_divergent_branch_00247 | GNL3 interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrated that NS could interact with a telomere-binding protein and enhance the degradation but not the ubiquitination of the protein, which negatively regulates telomere length and is essential for early embryogenesis.' Which... | kidney Wilms tumor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00247","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNL3 interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrated that NS could interact with a telomere-binding... | |
medium_divergent_branch_00248 | RAD51C interacts with multiple proteins. One interaction is supported by evidence stating: 'In contrast, Rad51C is pulled down with [Protein X], whereas XRCC2 and Rad51D are not.' Which protein, connected to RAD51C via a binding interaction, is described in this context? | DNA repair protein XRCC3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00248","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD51C interacts with multiple proteins. One interaction is supported by evidence stating: 'In contrast, Rad51C is pulled down with [Protein X], wher... | |
medium_divergent_branch_00250 | SFRP1 is associated with multiple biological processes. One association is supported by evidence showing that reducing SFRP1 expression leads to increased apoptosis. Which biological process, connected to the process involving SFRP1 via a 'negatively regulates' relationship, is consistent with this evidence? | apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00250","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SFRP1 is associated with multiple biological processes. One association is supported by evidence showing that reducing SFRP1 expression leads to incr... | |
medium_divergent_branch_00252 | The RB1 protein interacts with multiple partners. One specific interaction is supported by combined immunoprecipitation and western blot experiments, which revealed a physical association between phosphorylated and under-phosphorylated forms of RB and cyclin A complexes in U937V and U937VR cells. Which disease is assoc... | lung carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00252","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The RB1 protein interacts with multiple partners. One specific interaction is supported by combined immunoprecipitation and western blot experiments,... | |
medium_divergent_branch_00253 | RAD23B interacts with multiple proteins. One of these interaction partners forms a complex with RAD23B and CETN2, exhibiting binding characteristics of the full-length protein and stimulating DNA binding through physical interaction. Which protein is encoded by the gene corresponding to this interaction partner? | DNA repair protein complementing XP-C cells | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00253","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD23B interacts with multiple proteins. One of these interaction partners forms a complex with RAD23B and CETN2, exhibiting binding characteristics ... | |
medium_divergent_branch_00254 | PI4KB is associated with multiple biological processes. One association is supported by evidence that depleting PI4KB mRNA in zebrafish leads to inner ear abnormalities and audiosensory impairment, mirroring patient phenotypes. Which biological process, connected to the process implicated by this evidence via an 'is a'... | anatomical structure development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00254","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PI4KB is associated with multiple biological processes. One association is supported by evidence that depleting PI4KB mRNA in zebrafish leads to inne... | |
medium_divergent_branch_00256 | FERMT2 interacts with multiple genes. One specific interaction is supported by evidence stating that Kindlin-2 was found to interact with the target gene and recruit it to focal adhesions. Which disease is associated with this target gene via a biomarker relationship? | hemolytic-uremic syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00256","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FERMT2 interacts with multiple genes. One specific interaction is supported by evidence stating that Kindlin-2 was found to interact with the target ... | |
medium_divergent_branch_00257 | TNFRSF13B interacts with multiple proteins. One interaction is supported by evidence stating: 'A member of the tumor necrosis factor receptor superfamily was isolated by virtue of its affinity for a specific calcium-modulating ligand.' Which protein product is encoded by the gene corresponding to this specific interact... | Guided entry of tail-anchored proteins factor CAMLG | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00257","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNFRSF13B interacts with multiple proteins. One interaction is supported by evidence stating: 'A member of the tumor necrosis factor receptor superfa... | |
medium_divergent_branch_00258 | The protein CIB1 is associated with multiple biological processes. One association is supported by evidence stating: 'These data suggest that CIB1 is involved in regulating endomitosis, perhaps through its interaction with Plk3.' Identify the specific biological process described by this evidence, and then determine th... | mitotic cell cycle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00258","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CIB1 is associated with multiple biological processes. One association is supported by evidence stating: 'These data suggest that CIB1 is... | |
medium_divergent_branch_00259 | AIMP2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In particular, p38 was found to associate with itself to form a dimer, but also with p43, with the class I tRNA synthetases ArgRS and GlnRS, with the class II synthetases AspRS and LysRS, and with the bifunctional GluPro... | Arginine--tRNA ligase, cytoplasmic | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00259","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AIMP2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In particular, p38 was found to associate with it... | |
medium_divergent_branch_00260 | NSMCE2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We showed that hNSE6 binding to hNSE5 and the coiled-coil arm of hSMC6 is mediated by a conserved FAM178 domain, which we therefore renamed CANIN (Coiled-coil SMC6 And NSE5 INteracting) domain.' Which disease is associated with ... | Atelis syndrome 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00260","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NSMCE2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We showed that hNSE6 binding to hNSE5 and the coiled-coil... | |
medium_divergent_branch_00261 | TCF3 interacts with multiple genes. One of these interaction partners was identified through yeast two-hybrid screening of a neuroblastoma cDNA library, a process that selected this partner along with numerous additional members of the E-protein family. Which disease is associated with this specific interaction partner... | atrial septal defect | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00261","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TCF3 interacts with multiple genes. One of these interaction partners was identified through yeast two-hybrid screening of a neuroblastoma cDNA libra... | |
medium_divergent_branch_00262 | RBMX interacts with multiple genes. One of these interaction partners is described in the following context: 'Moreover, hnRNP-G and RBM non-specifically bind RNA, but directly and specifically bind Htra2-beta1, an SR-like splicing factor which we have previously shown to stimulate inclusion of exon 7 through a direct i... | progressive supranuclear palsy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00262","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBMX interacts with multiple genes. One of these interaction partners is described in the following context: 'Moreover, hnRNP-G and RBM non-specifica... | |
medium_divergent_branch_00263 | The gene SNCA interacts with multiple partners. One specific interaction is supported by evidence stating: 'A direct interaction between α-synuclein and the interaction partner was confirmed by GST pull-down and co-immunoprecipitation assays.' Which protein is encoded by the gene that interacts with SNCA in this manner... | Spectrin beta chain, non-erythrocytic 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00263","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SNCA interacts with multiple partners. One specific interaction is supported by evidence stating: 'A direct interaction between α-synuclein ... | |
medium_divergent_branch_00264 | SH3GLB1 interacts with multiple proteins. One interaction partner was identified in a yeast two-hybrid screen where reversing the prey-to-bait orientation revealed a second protein of 395 amino acids that shares 65% sequence identity with SH3GLB1. Which protein is encoded by the gene corresponding to this specific inte... | Endophilin-B2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00264","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SH3GLB1 interacts with multiple proteins. One interaction partner was identified in a yeast two-hybrid screen where reversing the prey-to-bait orient... | |
medium_divergent_branch_00265 | The sphenoid bone is classified as a type of anatomy. Evidence for one of these classifications describes the sphenoid as an unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. It is noted as one of the seven bones that articulate to form the orbit, with... | head bone | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00265","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The sphenoid bone is classified as a type of anatomy. Evidence for one of these classifications describes the sphenoid as an unpaired bone situated a... | |
medium_divergent_branch_00266 | The MHC class II protein complex is associated with multiple cell types via the plasma membrane. One specific connection involves a CD11b-positive dendritic cell characterized as CD11b-low, CD45-positive, MHC-II-high, and CD103-positive, which is located in the liver. Which anatomical structure is this specific cell ty... | hepatic sinusoid | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00266","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The MHC class II protein complex is associated with multiple cell types via the plasma membrane. One specific connection involves a CD11b-positive de... | |
medium_divergent_branch_00267 | The HTR4 gene enables multiple molecular functions. One specific function is supported by evidence stating that four splice variants transiently expressed in COS-7 cells displayed an identical 5-HT4 pharmacological profile and showed a similar ability to stimulate adenylyl cyclase activity in the presence of 5-HT. Whic... | G protein-coupled amine receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00267","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The HTR4 gene enables multiple molecular functions. One specific function is supported by evidence stating that four splice variants transiently expr... | |
medium_divergent_branch_00268 | RAB4A interacts with multiple proteins. One specific interaction partner is described as a novel 80-kDa protein that binds specifically to the GTP-bound conformation of Rab4 and also interacts strongly with Rab11. Which biological process is this specific interaction partner involved in? | negative regulation of adiponectin secretion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00268","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB4A interacts with multiple proteins. One specific interaction partner is described as a novel 80-kDa protein that binds specifically to the GTP-bo... | |
medium_divergent_branch_00269 | DHX16 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'We identified the RNA helicase DHX16 as a potential pattern recognition receptor (PRR).' Which molecular function, connected to the function described in this evidence via an... | signaling receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00269","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DHX16 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'We ... | |
medium_divergent_branch_00270 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.140 and an adjusted p-value of 0.0157. Which disease is associated with that selected gene? | acute myeloid leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00270","source_qa_id":"medium_divergent_branch_03937","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_00271 | Collagen trimers are structural components of various anatomical entities. One such entity is described as delicate strands of connective tissue that loosely connect the arachnoid mater and the pia mater within the subarachnoid space. These structures are embryologically derived from the common precursor of the arachno... | trabecula | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00271","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Collagen trimers are structural components of various anatomical entities. One such entity is described as delicate strands of connective tissue that... | |
medium_divergent_branch_00272 | CR1 is involved in multiple biological processes. One of these processes is characterized by the inhibition of B-cell differentiation into plasmablasts and the suppression of immunoglobulin production, in addition to blocking B-cell receptor-induced proliferation. Which biological process is negatively regulated by thi... | plasma cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00272","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CR1 is involved in multiple biological processes. One of these processes is characterized by the inhibition of B-cell differentiation into plasmablas... | |
medium_divergent_branch_00273 | BCL10 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that Bcl10 undergoes K63-linked polyubiquitination in response to T cell activation and subsequently binds the regulatory subunit of IKK.' Which protein, encoded by the gene connected to BCL10 via this specific inte... | NF-kappa-B essential modulator | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00273","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL10 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that Bcl10 undergoes K63-linked polyubiquiti... | |
medium_divergent_branch_00274 | FANCG is known to bind to multiple protein partners. One specific interaction partner is identified in studies showing that TPR-mutated FANCG proteins fail to co-immunoprecipitate with BRCA2, this partner, FANCA, or FANCF. Which gene, connected to FANCG via a binding relationship, is the subject of this specific intera... | TRIM25 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00274","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCG is known to bind to multiple protein partners. One specific interaction partner is identified in studies showing that TPR-mutated FANCG protein... | |
medium_divergent_branch_00275 | ERCC6 interacts with multiple proteins. One specific interaction partner is characterized by evidence stating that CSB interacts with the BRCT domain of this entity, and this interaction is regulated by CDK-dependent phosphorylation of CSB on S1276. Which protein is encoded by the gene corresponding to this interaction... | DNA endonuclease RBBP8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00275","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC6 interacts with multiple proteins. One specific interaction partner is characterized by evidence stating that CSB interacts with the BRCT domain... | |
medium_divergent_branch_00276 | TRIM59 interacts with multiple genes. One specific interaction is characterized by the following mechanism: in response to the onset of colitis, TRIM59 directly interacts with the partner protein to promote its ubiquitin-proteasome degradation. This process results in NRF2 activation and the subsequent activation of do... | CDH1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00276","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM59 interacts with multiple genes. One specific interaction is characterized by the following mechanism: in response to the onset of colitis, TRIM... | |
medium_divergent_branch_00277 | RBBP7 interacts with multiple proteins. One of these interaction partners is characterized by experimental evidence from glutathione S-transferase pull-down assays, which shows that it associates with several known components of the MeCP1.NuRD complex (including HDAC1, HDAC2, MTA2, MBD2, RbAp46, and RbAp48) but does no... | Methyl-CpG-binding domain protein 3-like 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00277","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBBP7 interacts with multiple proteins. One of these interaction partners is characterized by experimental evidence from glutathione S-transferase pu... | |
medium_divergent_branch_00278 | The Vitamin D Receptor (VDR) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The W286A mutant did not bind 1,25(OH)2D3, interact with steroid receptor coactivator 1 (SRC-1) in vitro, or activate transcription.' Which protein, encoded by the gene associated with this specifi... | Nuclear receptor coactivator 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00278","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The Vitamin D Receptor (VDR) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The W286A mutant did not b... | |
medium_divergent_branch_00279 | PDCD6IP interacts with multiple genes. One of these interactions is supported by evidence stating: 'We investigated interactions between a protein tyrosine phosphatase and Alix-binding proteins.' Which disease is associated with the gene identified by this specific evidence through a biomarker relationship? | mammary neoplasms, animal | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00279","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDCD6IP interacts with multiple genes. One of these interactions is supported by evidence stating: 'We investigated interactions between a protein ty... | |
medium_divergent_branch_00280 | The gene ACVR1B is linked via a binding interaction to more than one other gene. One specific interaction is supported by evidence stating that Activin binds directly to a type II activin receptor, and this complex associates with ActR-IB, which does not bind ligand on its own. Which protein is encoded by the gene conn... | Activin receptor type-2B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00280","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACVR1B is linked via a binding interaction to more than one other gene. One specific interaction is supported by evidence stating that Activ... | |
medium_divergent_branch_00281 | The gene ALAS2 is associated with multiple biological processes. One association is supported by evidence stating that a database search for proteins potentially regulated by oxygen tension revealed that ALAS2 contains a specific amino acid sequence (LXXLAP) not found in ALAS1, which may be hydroxylated under normoxic ... | intracellular chemical homeostasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00281","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ALAS2 is associated with multiple biological processes. One association is supported by evidence stating that a database search for proteins... | |
medium_divergent_branch_00282 | FAN1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identify a highly conserved SPYF motif at the N terminus of FAN1 that binds to the partner protein.' Which protein, among those interacting with FAN1, is the one described by this specific binding evidence? (Note: The fin... | DNA mismatch repair protein Mlh1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00282","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FAN1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identify a highly conserved SPYF motif at the N te... | |
medium_divergent_branch_00283 | SPTA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The antiparallel side-to-side association of spectrin alpha and beta monomers is a two-step process which occurs in seconds even at 0 degrees C and at low concentrations.' Which protein product is encoded by the gene that binds t... | Spectrin beta chain, erythrocytic | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00283","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SPTA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The antiparallel side-to-side association of spectrin alph... | |
medium_divergent_branch_00285 | CLEC7A is enriched in multiple cell types. One of these cell types exhibits a mean expression of 129.06 TPM, a z-score of 1.62, and a fold enrichment of 4.77. Which cell type does this specific cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00285","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLEC7A is enriched in multiple cell types. One of these cell types exhibits a mean expression of 129.06 TPM, a z-score of 1.62, and a fold enrichment... | |
medium_divergent_branch_00286 | ETS2 interacts with multiple proteins. One specific interaction is supported by evidence showing that a transcription factor and Ets-2 formed a complex in vitro in the absence of DNA, mediated by the binding of the POU domain of the transcription factor to a site located between the 'pointed' and DNA binding domains of... | POU domain, class 5, transcription factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00286","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ETS2 interacts with multiple proteins. One specific interaction is supported by evidence showing that a transcription factor and Ets-2 formed a compl... | |
medium_divergent_branch_00287 | EEF1B2 interacts with multiple genes. One interaction is supported by evidence stating that a human protein interacts with the metazoan-specific eukaryotic elongation factor 1Bδ (eEF1Bδ) and inhibits its guanine nucleotide exchange factor (GEF) activity, although the structural mechanism remains unknown. Which disease ... | Lyme disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00287","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EEF1B2 interacts with multiple genes. One interaction is supported by evidence stating that a human protein interacts with the metazoan-specific euka... | |
medium_divergent_branch_00288 | Primate erythroparvovirus 1 is reported to upregulate multiple genes. One specific upregulation event is characterized by a log2 fold change of approximately 1.055 and an adjusted p-value of 0.03565. Which protein is encoded by the gene associated with this specific statistical evidence? | Interstitial collagenase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00288","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Primate erythroparvovirus 1 is reported to upregulate multiple genes. One specific upregulation event is characterized by a log2 fold change of appro... | |
medium_divergent_branch_00289 | RAD17 interacts with multiple genes. One interaction is supported by evidence stating: 'The human Rad17-Rfc2-5 and Rad9-Rad1-Hus1 complexes play crucial roles in the activation of the ATR-mediated DNA damage and DNA replication stress response pathways.' Which disease is associated with the gene identified in this spec... | Morimoto-Ryu-Malicdan neuromuscular syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00289","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD17 interacts with multiple genes. One interaction is supported by evidence stating: 'The human Rad17-Rfc2-5 and Rad9-Rad1-Hus1 complexes play cruc... | |
medium_divergent_branch_00290 | The protein DIABLO (also known as SMAC) interacts with multiple inhibitors of apoptosis proteins. One specific interaction is supported by evidence stating: 'Here we report that Apollon binds to, ubiquitinates and facilitates proteasomal degradation of SMAC and caspase-9, which both contain IAP-binding motifs.' Which p... | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00290","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein DIABLO (also known as SMAC) interacts with multiple inhibitors of apoptosis proteins. One specific interaction is supported by evidence s... | |
medium_divergent_branch_00292 | DLC1 interacts with multiple genes. One of these interacting partners has been shown to directly interact with DLC1 in both in vitro and in vivo settings. Which disease is associated with this specific interacting gene via a biomarker relationship? | nephrotic syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00292","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLC1 interacts with multiple genes. One of these interacting partners has been shown to directly interact with DLC1 in both in vitro and in vivo sett... | |
medium_divergent_branch_00293 | The gene CISH interacts with multiple partners. One interaction is supported by evidence stating: 'The CIS product stably associated with the tyrosine-phosphorylated beta chain of the IL3 receptor as well as the tyrosine-phosphorylated EPO receptor.' Which protein is encoded by the gene that interacts with CISH in this... | Erythropoietin receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00293","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CISH interacts with multiple partners. One interaction is supported by evidence stating: 'The CIS product stably associated with the tyrosin... | |
medium_divergent_branch_00294 | HSP90B1 interacts with multiple proteins. One specific interaction partner was identified in a study using Affinity Capture-MS, where it was found to interact with heat shock protein 90 (HSP90) and impact the ubiquitination of eukaryotic elongation factor 2 kinase (EEF2K). Which protein corresponds to this interaction ... | E3 ubiquitin-protein ligase synoviolin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00294","source_qa_id":"medium_divergent_branch_02057","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"HSP90B1 interacts with multiple proteins. One specific interaction partner was identified in a st... | |
medium_divergent_branch_00295 | MTOR interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, we found that the interacting partner associated with mTORC1, an evolutionarily conserved serine/threonine kinase complex, which regulates cell growth and autophagy in response to environmental stimuli.' Which gene is ... | MTMR4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00295","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTOR interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, we found that the interacting partner associate... | |
medium_divergent_branch_00296 | BIRC3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Similarly to XIAP, in vitro binding experiments indicated that c-IAP-1 and c-IAP-2 bound specifically to the terminal effector cell death proteases, caspases-3 and -7, but not to the proximal protease caspase-8, caspases-1 or -6.... | Caspase-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00296","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIRC3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Similarly to XIAP, in vitro binding experiments indicated ... | |
medium_divergent_branch_00297 | RBPJ interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, using a proteomic approach, we identified a specific F-box protein as a previously unidentified RBPJ interactor.' Which biological process is the gene identified in this evidence involved in? | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00297","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBPJ interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, using a proteomic approach, we identified a spe... | |
medium_divergent_branch_00299 | RNF20 interacts with multiple genes. One specific interaction is characterized by the following evidence: 'Here, we show that the single-strand DNA-binding factor Replication protein A (RPA) interacts with RNF20 mainly in the S and G2/M phases and recruits RNF20 to mitotic centromeres in a centromeric R-loop-dependent ... | coronary artery disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00299","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF20 interacts with multiple genes. One specific interaction is characterized by the following evidence: 'Here, we show that the single-strand DNA-b... | |
medium_divergent_branch_00301 | The gene ACTB is associated with multiple biological processes. One association is supported by the evidence that 'Both actin isoforms are essential for normal barrier function of epithelial monolayers.' Identify the biological process linked to this specific association via an 'is a' relationship. | regulation of transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00301","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACTB is associated with multiple biological processes. One association is supported by the evidence that 'Both actin isoforms are essential ... | |
medium_divergent_branch_00302 | SIRT3 interacts with multiple genes. One specific interaction is supported by evidence showing that SIRT3 directly binds to and deacetylates the partner protein at lysine 228 (K228). Which disease is associated with this specific interacting partner? | PYCR1-related de Barsy syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00302","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIRT3 interacts with multiple genes. One specific interaction is supported by evidence showing that SIRT3 directly binds to and deacetylates the part... | |
medium_divergent_branch_00303 | Platelet degranulation is a subtype of multiple biological processes. One of these parent processes is defined by the release of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. Which biological process is the parent of platelet degranulation that fits this description? | exocytosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00303","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Platelet degranulation is a subtype of multiple biological processes. One of these parent processes is defined by the release of secretory granules c... | |
medium_divergent_branch_00304 | The gene GPSM1 (also known as AGS3) interacts with multiple proteins. One specific interaction is described by the following evidence: 'We demonstrate here that AGS3 interacts with a ubiquitin specific protease, and this interaction is at least partially mediated through the C-terminal G protein regulatory domain of AG... | Ubiquitin carboxyl-terminal hydrolase 9X | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00304","source_qa_id":"medium_divergent_branch_04222","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene GPSM1 (also known as AGS3) interacts with multiple proteins. One specific interaction is... | |
medium_divergent_branch_00305 | NPLOC4 interacts with multiple proteins. One specific interaction partner is identified by the evidence that a specific gene interacts with the p97 protein 'segregase'. Which disease is associated with this specific interaction partner? | progeroid features-hepatocellular carcinoma predisposition syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00305","source_qa_id":"medium_divergent_branch_02529","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"NPLOC4 interacts with multiple proteins. One specific interaction partner is identified by the ev... | |
medium_divergent_branch_00306 | KLF1 interacts with multiple genes. One interaction is supported by evidence stating: 'This repressive effect of the interacting partner requires the ETS DNA binding domain and its association with either the N- or C-terminal domain, which themselves interact with EKLF but not with GATA-1.' Which disease is associated ... | malignant soft tissue neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00306","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLF1 interacts with multiple genes. One interaction is supported by evidence stating: 'This repressive effect of the interacting partner requires the... | |
medium_divergent_branch_00307 | CUL7 is associated with multiple biological processes. One line of evidence states: 'These results suggest that the CUL7 E3 ligase is a key regulator in trophoblast cell epithelial-mesenchymal transition and placental development.' Based on this specific evidence, which biological process is linked to CUL7, and what is... | mesenchymal cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00307","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL7 is associated with multiple biological processes. One line of evidence states: 'These results suggest that the CUL7 E3 ligase is a key regulator... | |
medium_divergent_branch_00308 | PRMT1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Overexpression of PRMT1 in acute megakaryocytic leukemia cell lines blocks megakaryocyte terminal differentiation by downregulation of RBM15 protein level.' Which biological process is a parent term (via ... | regulation of myeloid cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00308","source_qa_id":"medium_divergent_branch_02160","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PRMT1 is associated with multiple biological processes. One specific association is supported by ... | |
medium_divergent_branch_00309 | RTN4 is known to interact with multiple proteins. One specific interaction is characterized by the following evidence: In normal liver cells, the interacting protein mainly localizes in the cytoplasm and mediates the ubiquitination of the oncoprotein neurite outgrowth inhibitor-B (Nogo-B, also known as reticulon 4 B) b... | Speckle-type POZ protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00309","source_qa_id":"medium_divergent_branch_03681","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RTN4 is known to interact with multiple proteins. One specific interaction is characterized by th... | |
medium_divergent_branch_00310 | RNF114 interacts with multiple genes. One of these interaction partners is known to interact with TNFAIP3 in T cells and modulate TNFAIP3 ubiquitylation. Which disease is associated with this specific interaction partner via a biomarker relationship? | myocarditis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00310","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF114 interacts with multiple genes. One of these interaction partners is known to interact with TNFAIP3 in T cells and modulate TNFAIP3 ubiquitylat... | |
medium_divergent_branch_00311 | The A1 adenosine receptor (ADORA1) is associated with multiple molecular functions. One specific function is supported by evidence showing that ADORA1 coimmunoprecipitates with Gq protein-coupled P2Y1 and P2Y2 receptors in cotransfected HEK293T cells, suggesting an oligomeric association between distinct G protein-coup... | signaling receptor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00311","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The A1 adenosine receptor (ADORA1) is associated with multiple molecular functions. One specific function is supported by evidence showing that ADORA... | |
medium_divergent_branch_00312 | PTPRM is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by the evidence: 'We observed a direct interaction between PTPmu and E-cadherin after coexpression in Sf9 cells.' Which molecular function, connected to the function supported by this evidence thr... | cell adhesion molecule binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00312","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPRM is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by the evidence: 'We obse... | |
medium_divergent_branch_00313 | SMAD3 is implicated in multiple biological processes. One such process is supported by evidence stating: 'On the other hand, BMP-3b directly activated Smad2/3 phosphorylation and activin/TGF-β target gene PAI-1 mRNA expression, while BMP-2 suppressed BMP-3b-induced Smad2/3 signal activation.' Identify the biological pr... | ossification | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00313","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD3 is implicated in multiple biological processes. One such process is supported by evidence stating: 'On the other hand, BMP-3b directly activate... | |
medium_divergent_branch_00315 | RNF216 interacts with multiple genes. One of these interaction partners is identified as an E2 enzyme that forms a stable complex with RNF216, which acts as an E3 ligase. Which disease is associated with this specific interaction partner through genomic alterations? | systemic lupus erythematosus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00315","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF216 interacts with multiple genes. One of these interaction partners is identified as an E2 enzyme that forms a stable complex with RNF216, which ... | |
medium_divergent_branch_00316 | PTPRA is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'PTPRA directly interacts with this partner, and using the phosphoproteomic approach, we identify this partner as a direct dephosphorylation substrate of PTPRA both in vivo and in vitro.' Which protein is en... | Proto-oncogene tyrosine-protein kinase receptor Ret | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00316","source_qa_id":"medium_divergent_branch_01501","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PTPRA is reported to interact with multiple proteins. One specific interaction is supported by ev... | |
medium_divergent_branch_00317 | HMGB2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We have mapped the interaction domains for both proteins and have shown that HMG2 and Oct2 interact via their HMG domains and POU homeodomains, respectively.' Which protein, encoded by the gene connected to HMGB2 through... | POU domain, class 2, transcription factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00317","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMGB2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We have mapped the interaction domains for both p... | |
medium_divergent_branch_00318 | The gene GET3 is reported to interact with multiple partners. One specific interaction involves the ASNA1 subunit of the transmembrane-domain recognition complex (TRC), which contains an FFAT-like motif that mediates its binding to the MSP domain of a specific protein partner. Which protein is encoded by the gene corre... | Vesicle-associated membrane protein-associated protein B/C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00318","source_qa_id":"medium_divergent_branch_01843","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene GET3 is reported to interact with multiple partners. One specific interaction involves t... | |
medium_divergent_branch_00320 | CDK1 is enriched in multiple cell types. One of these cell types shows a mean expression of 3.82 TPM, a z-score of 2.48, and a fold enrichment of 6.44. Which cell type is the parent class of the cell type exhibiting these specific expression statistics? | group 1 innate lymphoid cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00320","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK1 is enriched in multiple cell types. One of these cell types shows a mean expression of 3.82 TPM, a z-score of 2.48, and a fold enrichment of 6.4... | |
medium_divergent_branch_00321 | BCL11B interacts with multiple genes. One specific interaction is supported by evidence stating: 'We report that CTIP2 represses the [gene]- and COUP-TF-mediated activation of HIV-1 gene transcription and viral replication as a result of physical interactions with COUP-TF and the [gene] in microglial nuclei.' Which dis... | hypertensive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00321","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL11B interacts with multiple genes. One specific interaction is supported by evidence stating: 'We report that CTIP2 represses the [gene]- and COUP... | |
medium_divergent_branch_00322 | ORC2 interacts with multiple proteins. Evidence for one specific interaction reports the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4, HsOrc3-HsOrc4, HsOrc2-HsOrc6, and HsOrc3-HsOrc6. Which disease is connected to the gene involved in this specific interaction through genomic alterations? | Meier-Gorlin syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00322","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ORC2 interacts with multiple proteins. Evidence for one specific interaction reports the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4,... | |
medium_divergent_branch_00323 | RUVBL1 is associated with multiple molecular functions. One specific function is supported by evidence stating that NOPCHAP1 makes direct physical interactions with the CC-NOP domain of NOP58 and domain II of the RUVBL1/2 AAA+ ATPases. Which molecular function, connected to this specific function via an 'is a' relation... | ribonucleoside triphosphate phosphatase activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00323","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RUVBL1 is associated with multiple molecular functions. One specific function is supported by evidence stating that NOPCHAP1 makes direct physical in... | |
medium_divergent_branch_00324 | HDAC6 is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating that HDAC6 is localized in the cytoplasm and enriched at the centrosome and basal body. Which cellular component, connected to HDAC6 through this specific evidence-supported 'l... | cilium | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00324","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC6 is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating that ... | |
medium_divergent_branch_00325 | NEK9 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'Nek2, Nek6, Nek7, and NEK9 are NIMA-related kinases essential for proper mitotic progression.' Which biological process is a parent term (linked by 'is a') to the biologi... | regulation of cell cycle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00325","source_qa_id":"medium_divergent_branch_03416","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"NEK9 is associated with multiple biological processes via the 'involved in' relationship. One spe... | |
medium_divergent_branch_00326 | PLEC interacts with multiple genes. One interaction is supported by evidence stating: 'In solid-phase binding assays, plectin bound to vimentin, microtubule-associated proteins 1 and 2, the 240-kDa chain of brain fodrin, and alpha-spectrin from human erythrocytes.' Which disease is connected to the gene identified by t... | immunoglobulin A vasculitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00326","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLEC interacts with multiple genes. One interaction is supported by evidence stating: 'In solid-phase binding assays, plectin bound to vimentin, micr... | |
medium_divergent_branch_00327 | ADAR interacts with multiple proteins. One interaction is supported by evidence stating: 'In concurrence, the protein encoded by XPO1 and RanGTP interact specifically with the ADAR1 nuclear export signal to form a tripartite export complex in vitro.' Which protein, connected to ADAR via an interaction, is the subject o... | Exportin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00327","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAR interacts with multiple proteins. One interaction is supported by evidence stating: 'In concurrence, the protein encoded by XPO1 and RanGTP inte... | |
medium_divergent_branch_00328 | PIK3R1 interacts with multiple proteins. One of these interaction partners is described as an adaptor protein that interacts with the regulatory p85 subunit of phosphatidylinositol 3-kinase, phospholipase C-gamma, and SOCS family members (SOCS2, SOCS6, and SOCS7), thereby modulating LR signaling. Which protein correspo... | Insulin receptor substrate 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00328","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIK3R1 interacts with multiple proteins. One of these interaction partners is described as an adaptor protein that interacts with the regulatory p85 ... | |
medium_divergent_branch_00329 | FANCI interacts with multiple proteins. One of these interaction partners is known to bind directly to a SUMO-like domain-interacting motif (SIM) on FANCI. Which protein, among the interactors of FANCI, is described by this specific binding evidence? | WD repeat-containing protein 48 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00329","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCI interacts with multiple proteins. One of these interaction partners is known to bind directly to a SUMO-like domain-interacting motif (SIM) on ... | |
medium_divergent_branch_00330 | The gene ID3 interacts with multiple partners. One specific interaction is supported by evidence stating: 'We have used an interaction cloning strategy to identify an inhibitory isoform of the ITF-2 transcription factor, ITF-2b, that interacts with the transcriptional inhibitor Id3/HLH462.' Which protein is encoded by ... | Transcription factor 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00330","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ID3 interacts with multiple partners. One specific interaction is supported by evidence stating: 'We have used an interaction cloning strate... | |
medium_divergent_branch_00331 | CDH2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using deletion mutagenesis we have found that the adhesion molecule/FGFR interaction can withstand the removal of most of any one of the FGFR immunoglobulin-like domains (D1-D3).' Which protein, among those interacting with CDH2, ... | Fibroblast growth factor receptor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00331","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDH2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using deletion mutagenesis we have found that the adhesion ... |
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