qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_divergent_branch_00332 | HSF1 interacts with multiple genes. One of these interacting partners phosphorylates HSF1 at Serine 216 within the DSGXXS motif during mitosis. Which disease is associated with this specific interacting gene through genomic alterations? | glioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00332","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSF1 interacts with multiple genes. One of these interacting partners phosphorylates HSF1 at Serine 216 within the DSGXXS motif during mitosis. Which... | |
medium_divergent_branch_00333 | The yolk sac cavity is a subtype of two distinct anatomical structures. One of these structures is defined as an anatomical cavity that is part of a yolk sac. Which anatomical structure is the yolk sac cavity a subtype of, based on this definition? | anatomical space | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00333","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The yolk sac cavity is a subtype of two distinct anatomical structures. One of these structures is defined as an anatomical cavity that is part of a ... | |
medium_divergent_branch_00334 | The gene LMO7 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 8.89 TPM, a z-score of 1.78, and a fold enrichment of 3.33. Identify the cell type that develops from the cell type associated with these specific expression statistics. | mature CD8 single-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00334","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene LMO7 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 8.89 TPM, a z-score of 1.... | |
medium_divergent_branch_00335 | CHD1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We found that CHD1 co-immunoprecipitates with histone deacetylase (HDAC) activity and that CHD1 also associates with a transcriptional corepressor, in yeast two-hybrid and in vitro pull-down assays.' Which disease is asso... | lung adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00335","source_qa_id":"medium_divergent_branch_04232","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CHD1 interacts with multiple proteins. One specific interaction is supported by evidence stating:... | |
medium_divergent_branch_00336 | WWP1 interacts with multiple proteins. One of these interaction partners is described as heterodimerizing with WWP1 and specifically ubiquitinating and degrading ΔNp73. Which protein corresponds to this description? | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00336","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WWP1 interacts with multiple proteins. One of these interaction partners is described as heterodimerizing with WWP1 and specifically ubiquitinating a... | |
medium_divergent_branch_00337 | The gene TNFRSF13B (encoding TACI) has multiple protein interaction partners. One specific interaction was identified via yeast two-hybrid screening of a B cell library using the TACI intracellular domain, which revealed that TACI interacts with TNFR-associated factors (TRAF) 2, 5, and 6. Which protein, among the candi... | TNF receptor-associated factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00337","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TNFRSF13B (encoding TACI) has multiple protein interaction partners. One specific interaction was identified via yeast two-hybrid screening ... | |
medium_divergent_branch_00338 | The gene DNAH7 is associated with multiple biological processes. One specific association is supported by evidence stating: 'These studies identify DNAH7 as an inner arm component of human cilia that is synthesized but not assembled in a case of PCD.' Identify the biological process linked to this specific association ... | microtubule-based movement | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00338","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DNAH7 is associated with multiple biological processes. One specific association is supported by evidence stating: 'These studies identify D... | |
medium_divergent_branch_00339 | TNFAIP6 is associated with multiple biological processes. One association is supported by evidence stating: 'We further observed that TSG-6 suppresses CXCL8-mediated chemotaxis of neutrophils.' Which biological process is negatively regulated by the process linked to TNFAIP6 via this specific evidence? | neutrophil chemotaxis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00339","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNFAIP6 is associated with multiple biological processes. One association is supported by evidence stating: 'We further observed that TSG-6 suppresse... | |
medium_divergent_branch_00340 | AKAP11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using yeast two-hybrid screening, we found that GSK-3beta binds to AKAP220, which is known to act as an A-kinase anchoring protein.' Note that AKAP220 is an alternative name for AKAP11. Which protein, among those interacting wit... | Glycogen synthase kinase-3 beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00340","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKAP11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using yeast two-hybrid screening, we found that GSK-3beta... | |
medium_divergent_branch_00341 | RFC2 interacts with multiple genes. One interaction is supported by evidence describing the isolation of a stable complex composed of the p40, p37, and p36 subunits of hRFC from baculovirus-infected insect cells. Which disease is associated with the gene identified by this evidence? | Morimoto-Ryu-Malicdan neuromuscular syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00341","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RFC2 interacts with multiple genes. One interaction is supported by evidence describing the isolation of a stable complex composed of the p40, p37, a... | |
medium_divergent_branch_00342 | NCF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Isothermal titration calorimetry measurements of the interactions between the individual components of this complex demonstrate that p67(phox) is the primary binding partner of p47(phox) in the resting state.' Which protein, encod... | Neutrophil cytosol factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00342","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Isothermal titration calorimetry measurements of the intera... | |
medium_divergent_branch_00343 | TRIM27 interacts with multiple proteins. One specific interaction is characterized by the binding partner attaching to TRIM27 via its N-terminus, where a reduction in this binding affinity significantly diminishes the partner's oncogenic activity. Which protein is encoded by the gene corresponding to this specific bind... | Tuftelin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00343","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM27 interacts with multiple proteins. One specific interaction is characterized by the binding partner attaching to TRIM27 via its N-terminus, whe... | |
medium_divergent_branch_00344 | The gene EIF2B3 interacts with multiple other genes. One of these interacting partners is described by evidence stating that removal of either the N- or C-terminal conserved domains of the protein encoded by this partner leads to a significant loss of GEF activity and reduced or abolished interaction with the alpha-, g... | Translation initiation factor eIF2B subunit epsilon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00344","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF2B3 interacts with multiple other genes. One of these interacting partners is described by evidence stating that removal of either the N-... | |
medium_divergent_branch_00346 | RUNX3 interacts with multiple genes via binding interactions. One specific interaction is supported by evidence stating: 'Immunoprecipitation experiments demonstrated that RUNX3 forms a complex with the protein encoded by the gene connected to RUNX3 through this specific binding interaction in cells.' Which protein is ... | Cellular tumor antigen p53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00346","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RUNX3 interacts with multiple genes via binding interactions. One specific interaction is supported by evidence stating: 'Immunoprecipitation experim... | |
medium_divergent_branch_00347 | The gene LAX1 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data suggested that LAX functions to negatively regulate signaling in lymphocytes.' Identify the cell type that enables the biological process linked to this specific evidence. | splenic red pulp macrophage | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00347","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene LAX1 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data suggested that LAX functi... | |
medium_divergent_branch_00349 | LIN28B interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrated that the histone acetyltransferase [Gene A], via its cold shock domain, directly interacts with and subsequently acetylates LIN28B in lung adenocarcinoma-derived H1299 cells.' Which cell type is the gene encoding [G... | gamma-delta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00349","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LIN28B interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrated that the histone acetyltransferase [Gene A],... | |
medium_divergent_branch_00351 | IRS2 is associated with multiple biological processes. One association is supported by evidence stating: 'A key role of IRS-2 and Akt1 in lipid metabolism was revealed.' Identify the biological process linked to this specific IRS2 function via an 'is a' relationship. | regulation of primary metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00351","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRS2 is associated with multiple biological processes. One association is supported by evidence stating: 'A key role of IRS-2 and Akt1 in lipid metab... | |
medium_divergent_branch_00352 | TGFBR1 interacts with multiple genes. One of these interacting partners is reported to interact with TGFBR1 and TGFBR2 upon TGF-β stimulation, remove K33-linked polyubiquitin chains from Lys502 of TGFBR1, and promote the recruitment of SMAD2/3. Which disease is associated with this specific interacting gene? | cervical cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00352","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TGFBR1 interacts with multiple genes. One of these interacting partners is reported to interact with TGFBR1 and TGFBR2 upon TGF-β stimulation, remove... | |
medium_divergent_branch_00353 | IGHV1OR15-4 is enriched in more than one cell type. One association is characterized by a mean expression of 6.70 TPM, a z-score of 2.76, and a fold enrichment of 13.53. What is the immediate parent category of the cell type that best matches this expression profile? | mature B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00353","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGHV1OR15-4 is enriched in more than one cell type. One association is characterized by a mean expression of 6.70 TPM, a z-score of 2.76, and a fold ... | |
medium_divergent_branch_00354 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.272 and an adjusted p-value of 0.0418. Which disease is associated with that selected gene? | carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00354","source_qa_id":"medium_divergent_branch_04508","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_00355 | SOD1 interacts with multiple proteins. One of these interaction partners is characterized by its ability to bind ATG8 family proteins, with a preference for LC3C, and it directly interacts with SOD1. Which protein corresponds to this description? | Tumor protein p53-inducible nuclear protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00355","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOD1 interacts with multiple proteins. One of these interaction partners is characterized by its ability to bind ATG8 family proteins, with a prefere... | |
medium_divergent_branch_00356 | RAD51B interacts with multiple proteins. One of these interaction partners is part of a complex defined as BCDX2, which contains RAD51B, RAD51C, RAD51D, and the partner protein. Which protein is this partner, and what protein product does the gene encoding this partner produce? | DNA repair protein XRCC2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00356","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD51B interacts with multiple proteins. One of these interaction partners is part of a complex defined as BCDX2, which contains RAD51B, RAD51C, RAD5... | |
medium_divergent_branch_00357 | Nicastrin (NCSTN) interacts with multiple genes. One interaction is supported by evidence stating that Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with presenilin 1 and a second presenilin gene. Which disease is associated with the gene identified in this specific evidence through gen... | dementia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00357","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Nicastrin (NCSTN) interacts with multiple genes. One interaction is supported by evidence stating that Nicastrin, a transmembrane glycoprotein, forms... | |
medium_divergent_branch_00358 | MIR221 is associated with multiple biological processes. One association is supported by evidence stating: 'Here, we identify the microRNA-221 (miR-221), a small noncoding RNA, as a modulator of the phenotypic change of vSMCs in response to PDGF signaling.' Which biological process is negatively regulated by the proces... | vascular associated smooth muscle cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00358","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR221 is associated with multiple biological processes. One association is supported by evidence stating: 'Here, we identify the microRNA-221 (miR-2... | |
medium_divergent_branch_00359 | DDRGK1 is associated with multiple biological processes. One association is supported by evidence stating that 'Microarray analysis indicated that the expression of NF-κB target genes showed the most significant decrease after depleting of DDRGK1.' Identify the biological process that is positively regulated by the pro... | gene expression | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00359","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDRGK1 is associated with multiple biological processes. One association is supported by evidence stating that 'Microarray analysis indicated that th... | |
medium_divergent_branch_00360 | RAB27A is associated with multiple biological processes. One association is supported by evidence stating: 'Using an RNA interference (RNAi) screen, we identified five Rab GTPases that promote exosome secretion in HeLa cells. Among these, RAB27A and Rab27b were found to function in MVE docking at the plasma membrane.' ... | exocytosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00360","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB27A is associated with multiple biological processes. One association is supported by evidence stating: 'Using an RNA interference (RNAi) screen, ... | |
medium_divergent_branch_00361 | CHD7 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The result was confirmed by a direct yeast two-hybrid analysis, co-immunoprecipitation studies and by a bimolecular fluorescence complementation assay.' Which protein, among those interacting with CHD7, is the subject of ... | ATP-dependent chromatin remodeler CHD8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00361","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHD7 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The result was confirmed by a direct yeast two-hyb... | |
medium_divergent_branch_00362 | CPEB2 interacts with multiple proteins. One specific interaction involves the formation of a disulfide bond that results in the negative regulation of hypoxia-inducible factor 1-alpha (HIF-1α) RNA translation. Which protein, connected to CPEB2 through this specific interaction, is encoded by the gene in question? | Glutathione peroxidase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00362","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CPEB2 interacts with multiple proteins. One specific interaction involves the formation of a disulfide bond that results in the negative regulation o... | |
medium_divergent_branch_00363 | NLRP3 interacts with multiple proteins. One specific interaction partner is characterized by its ability to recognize Trp-73 within NALP3 for binding and to target Lys-689 within NALP3 for ubiquitin ligation and subsequent degradation. Which protein corresponds to this interaction partner? | F-box/LRR-repeat protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00363","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NLRP3 interacts with multiple proteins. One specific interaction partner is characterized by its ability to recognize Trp-73 within NALP3 for binding... | |
medium_divergent_branch_00364 | KLHL2 is reported to interact with multiple genes. One piece of evidence states: 'We found that KLHL2, as well as KLHL3, was co-immunoprecipitated with all four WNK isoforms.' Which gene, linked to KLHL2 by the 'interacts with' relation, is supported by this specific evidence, and what is the gene that this identified ... | CUL3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00364","source_qa_id":"medium_divergent_branch_03299","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"KLHL2 is reported to interact with multiple genes. One piece of evidence states: 'We found that K... | |
medium_divergent_branch_00365 | DCUN1D1 interacts with multiple proteins. Experimental evidence from an Affinity Capture-MS study identifies RBX1 and RPS19, along with other specific proteins, as binding partners of DCUN1D1. Which of the interacting proteins is encoded by the gene connected to DCUN1D1 via this interaction? | Cullin-4B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00365","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DCUN1D1 interacts with multiple proteins. Experimental evidence from an Affinity Capture-MS study identifies RBX1 and RPS19, along with other specifi... | |
medium_divergent_branch_00366 | TANK interacts with multiple proteins. One specific interaction is supported by TAP studies showing that three proteins expressed in HEK-293T cells (NAP1, the target protein, and TBKBP1) interact with the target protein. Which disease is associated with this target protein as a biomarker? | myelofibrosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00366","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TANK interacts with multiple proteins. One specific interaction is supported by TAP studies showing that three proteins expressed in HEK-293T cells (... | |
medium_divergent_branch_00367 | USP16 interacts with multiple proteins. One specific interaction is described by the following evidence: 'Here we report that the histone H2A deubiquitinase USP16 interacts with this protein, fine-tunes the ubiquitin signal during repair, and importantly, is required for terminating the ubiquitination signal after repa... | E3 ubiquitin-protein ligase HERC2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00367","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP16 interacts with multiple proteins. One specific interaction is described by the following evidence: 'Here we report that the histone H2A deubiqu... | |
medium_divergent_branch_00368 | The gene AGRP interacts with multiple partners via binding. One specific interaction is characterized by Agouti-related protein acting as an endogenous antagonist of a melanocortin receptor, a mechanism involved in the hypothalamic control of feeding behavior. Which disease is associated with this specific interacting ... | cocaine dependence | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00368","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AGRP interacts with multiple partners via binding. One specific interaction is characterized by Agouti-related protein acting as an endogeno... | |
medium_divergent_branch_00369 | SIRT2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, using bioinformatics, gene expression profiling, protein overexpression approaches, and cell migration assays, we showed that E3 ubiquitin ligase 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase degradatio... | E3 ubiquitin-protein ligase synoviolin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00369","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIRT2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, using bioinformatics, gene expression profi... | |
medium_divergent_branch_00370 | EIF3I interacts with multiple genes. One interaction is supported by evidence stating that activating mTOR signaling with insulin increased the amount of a translation initiation factor bound to eIF3 by as much as five-fold. Which disease is associated with the gene identified by this evidence via a biomarker relations... | myocardial ischemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00370","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF3I interacts with multiple genes. One interaction is supported by evidence stating that activating mTOR signaling with insulin increased the amoun... | |
medium_divergent_branch_00371 | GADD45B interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using a yeast two-hybrid method, three related proteins, GADD45alpha (= GADD45), GADD45, (= MyD118), and GADD45gamma, were identified that bound to an N-terminal domain of a specific kinase.' Which protein, connected t... | Mitogen-activated protein kinase kinase kinase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00371","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GADD45B interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using a yeast two-hybrid method, three related ... | |
medium_divergent_branch_00372 | KMT2A interacts with multiple proteins. One specific interaction involves a new site between the MLL1 SET domain and the WD40 β-propeller domain of the partner protein, demonstrating that the catalytic function of the complex is susceptible to disruption of this site. Which protein, encoded by the gene connected to KMT... | Retinoblastoma-binding protein 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00372","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KMT2A interacts with multiple proteins. One specific interaction involves a new site between the MLL1 SET domain and the WD40 β-propeller domain of t... | |
medium_divergent_branch_00373 | CSNK2A2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we determine that these proteins interact in vitro and in cells via non-overlapping domains.' Identify the disease associated with the protein that exhibits this specific interaction pattern with CSNK2A2. | neurodevelopmental disorder with dysmorphic facies and thin corpus callosum | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00373","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CSNK2A2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we determine that these proteins interact ... | |
medium_divergent_branch_00374 | LEMD3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, LEMD3 interacted with BMP and activin-TGFbeta receptor-activated Smads and antagonized both signaling pathways in human cells.' Which protein, connected to LEMD3 via this specific interaction evidence, is the subje... | SMAD family member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00374","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LEMD3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, LEMD3 interacted with BMP and activin-TGFbe... | |
medium_divergent_branch_00375 | The MAX protein interacts with multiple partners. One interaction is supported by evidence stating: 'Through interaction mating and immunoprecipitation techniques, we demonstrate that the protein encoded by the MNT gene heterodimerizes with Max and weakly homodimerizes.' Which protein is encoded by the gene that intera... | Max-binding protein MNT | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00375","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The MAX protein interacts with multiple partners. One interaction is supported by evidence stating: 'Through interaction mating and immunoprecipitati... | |
medium_divergent_branch_00376 | PACSIN2 interacts with multiple genes. One of these interaction partners is described by the evidence: 'All isoforms potentially oligomerize and bind to dynamin, synaptojanin 1 and a WAS family protein via their Src homology 3 domains.' Which disease is associated with this specific interaction partner? | ovarian neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00376","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PACSIN2 interacts with multiple genes. One of these interaction partners is described by the evidence: 'All isoforms potentially oligomerize and bind... | |
medium_divergent_branch_00377 | DNTT interacts with multiple proteins. One interaction is supported by evidence stating: 'Terminal deoxynucleotidyltransferase (TdT) was detected as a BPOZ-2-binding protein using a yeast two-hybrid system by screening a human thymus cDNA library.' Which protein, connected to DNTT via this specific interaction evidence... | Ankyrin repeat and BTB/POZ domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00377","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNTT interacts with multiple proteins. One interaction is supported by evidence stating: 'Terminal deoxynucleotidyltransferase (TdT) was detected as ... | |
medium_divergent_branch_00378 | SLIT2 is involved in multiple biological processes. One such process is characterized by the mechanism where, upon binding to Robo receptors, SLIT2 repels developing axons and inhibits leukocyte chemotaxis. Which biological process is negatively regulated by this specific SLIT2-associated process? | mononuclear cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00378","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLIT2 is involved in multiple biological processes. One such process is characterized by the mechanism where, upon binding to Robo receptors, SLIT2 r... | |
medium_divergent_branch_00379 | The gene HELQ interacts with multiple partners. One specific interaction is supported by evidence stating: 'We establish that HELQ interacts directly with the RAD51 paralogue complex BCDX2 and functions in parallel to the Fanconi anaemia pathway to promote efficient homologous recombination at damaged replication forks... | DNA repair protein RAD51 homolog 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00379","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HELQ interacts with multiple partners. One specific interaction is supported by evidence stating: 'We establish that HELQ interacts directly... | |
medium_divergent_branch_00380 | STX4 interacts with multiple proteins. One specific interaction was identified using microcapillary reverse-phase high-performance liquid chromatography-nano-electrospray tandem mass spectrometry, which revealed VAMP-3 and a second VAMP isoform as isoforms coimmunoprecipitated from platelets with syntaxin 4. Which prot... | Vesicle-associated membrane protein 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00380","source_qa_id":"medium_divergent_branch_00792","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"STX4 interacts with multiple proteins. One specific interaction was identified using microcapilla... | |
medium_divergent_branch_00381 | RASSF1 interacts with multiple genes. One of these interaction partners is described as a substrate adaptor that directly interacts with RASSF1A and bridges it to the CUL4A E3 ligase complex. Which disease is associated with this specific interaction partner? | White-Kernohan syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00381","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RASSF1 interacts with multiple genes. One of these interaction partners is described as a substrate adaptor that directly interacts with RASSF1A and ... | |
medium_divergent_branch_00382 | TRIP6 interacts with multiple proteins. One of these interactions is characterized by direct binding to the carboxyl-terminal tail of the LPA(2) receptor via LIM domains. Which gene encodes the protein that interacts with TRIP6 in this specific manner? | Lysophosphatidic acid receptor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00382","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIP6 interacts with multiple proteins. One of these interactions is characterized by direct binding to the carboxyl-terminal tail of the LPA(2) rece... | |
medium_divergent_branch_00383 | The protein FOS interacts with multiple partners. One specific interaction is characterized by the binding of a partner protein to c-Fos through specific phospho-Ser/Thr-Pro (pS/T-P) sites within the c-Fos transactivation domain (TAD), an interaction that enhances the transcriptional response of c-Fos to polypeptide gr... | hypogonadotropic hypogonadism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00383","source_qa_id":"medium_divergent_branch_03418","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein FOS interacts with multiple partners. One specific interaction is characterized by th... | |
medium_divergent_branch_00384 | WDR11 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'structured illumination microscopy and relocation assays indicate that the WDR11 complex is initially recruited onto vesicles rather than the TGN'. Which cellular componen... | intracellular vesicle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00384","source_qa_id":"medium_divergent_branch_03685","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"WDR11 is associated with multiple cellular components via the 'located in' relationship. One spec... | |
medium_divergent_branch_00385 | EIF5 interacts with multiple proteins. One of these interaction partners is reported to be bound within eIF3 complexes isolated from transfected cell lysates, suggesting that this specific physical interaction is important for the function of the partner protein during translation initiation in eukaryotic cells. Which ... | Eukaryotic translation initiation factor 3 subunit G | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00385","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF5 interacts with multiple proteins. One of these interaction partners is reported to be bound within eIF3 complexes isolated from transfected cell... | |
medium_divergent_branch_00386 | FGF2 interacts with multiple proteins. One specific interaction partner is characterized by strong binding to FGF-2, alongside FGFR2 and FGFR4, but exhibits poor interaction with KGFR. Which cell type is enriched in the gene encoding this specific interaction partner? | gamma-delta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00386","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF2 interacts with multiple proteins. One specific interaction partner is characterized by strong binding to FGF-2, alongside FGFR2 and FGFR4, but e... | |
medium_divergent_branch_00387 | AP4E1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have shown by a combination of coimmunoprecipitation and yeast two-hybrid analysis that these four proteins (epsilon, beta4, mu4, and sigma4) are components of a novel adaptor-like heterotetrameric complex, which we are callin... | AP-4 complex subunit mu-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00387","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AP4E1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have shown by a combination of coimmunoprecipitation an... | |
medium_divergent_branch_00388 | BMP7 is associated with multiple biological processes. One association is supported by evidence stating: 'These results suggest different mechanisms for BMP-2/4- and BMP-6/7-induced osteoblastic differentiation in primary hMSC.' Identify the biological process that is positively regulated by the process linked to BMP7 ... | osteoblast differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00388","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMP7 is associated with multiple biological processes. One association is supported by evidence stating: 'These results suggest different mechanisms ... | |
medium_divergent_branch_00389 | MAP1LC3A interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Strikingly, in addition to ULK1 and ULK2, this protein and FIP200 interacted with human ATG8 proteins, all with strong preference for the GABARAP subfamily.' Which protein is encoded by the gene corresp... | Autophagy-related protein 13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00389","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP1LC3A interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Strikingly, in addition to ULK1... | |
medium_divergent_branch_00390 | EFNB2 interacts with multiple proteins. One interaction is characterized by a peptide situated in a hydrophobic cleft of the binding partner, corresponding to the cleft occupied by the ephrin-B2 G-H loop, which is consistent with antagonistic properties. Which disease is associated with this specific binding partner th... | vein of Galen aneurysm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00390","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EFNB2 interacts with multiple proteins. One interaction is characterized by a peptide situated in a hydrophobic cleft of the binding partner, corresp... | |
medium_divergent_branch_00391 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.886 and an adjusted p-value of 0.0471. Which protein does that selected gene encode? | Protein S100-P | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00391","source_qa_id":"medium_divergent_branch_01955","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_00392 | PRKDC interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Moreover, DNA-PKc physically interacts with ARHGEF6 and a tumor suppressor protein mostly in the nucleus of Cbl-treated cells, whereas in Cbl(cos)-treated cells, its interactions are mostly in the cytoplasm.' Which prote... | Cellular tumor antigen p53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00392","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKDC interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Moreover, DNA-PKc physically interacts with ARHGE... | |
medium_divergent_branch_00393 | BRAF interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Biochemical analysis demonstrates that Raf-Arg59 and Raf-Arg67 from RafRBD are interacting residues complementary to Ras-Glu37 located in the Ras effector region.' Which protein, connected to BRAF via this interaction, is... | GTPase NRas | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00393","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRAF interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Biochemical analysis demonstrates that Raf-Arg59 a... | |
medium_divergent_branch_00394 | IRF2BP1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We have identified two novel proteins that interact specifically with the C-terminal repression domain of a transcription factor involved in immune regulation.' Which disease is associated with the gene described in this ... | allergic asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00394","source_qa_id":"medium_divergent_branch_02093","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"IRF2BP1 interacts with multiple genes. One specific interaction is supported by evidence stating:... | |
medium_divergent_branch_00395 | OPHN1 is associated with multiple biological processes. One association is supported by a study analyzing OPHN1-deficient human induced pluripotent stem cells (h-iPSCs), which examined morphological, biochemical, and functional features and their rescue via the ROCK inhibitor fasudil. This work highlighted the role of ... | cell morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00395","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OPHN1 is associated with multiple biological processes. One association is supported by a study analyzing OPHN1-deficient human induced pluripotent s... | |
medium_divergent_branch_00396 | TP53BP2 interacts with multiple genes. One of these interacting partners is known to interact with ASPP2 and mediate its degradation and ubiquitination in vivo. Which disease is associated with this specific interacting partner? | syndromic multisystem autoimmune disease due to ITCH deficiency | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00396","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TP53BP2 interacts with multiple genes. One of these interacting partners is known to interact with ASPP2 and mediate its degradation and ubiquitinati... | |
medium_divergent_branch_00397 | DNMT3B interacts with multiple proteins. One interaction partner is described as co-purifying and interacting, both in vivo and in vitro, with several components of the condensin complex (hCAP-C, hCAP-E, and a third component) as well as KIF4A. Which protein corresponds to this interaction partner? | Condensin complex subunit 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00397","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNMT3B interacts with multiple proteins. One interaction partner is described as co-purifying and interacting, both in vivo and in vitro, with severa... | |
medium_divergent_branch_00399 | Oxazepam interacts with multiple substances. One of these substances is characterized by cross-tolerance with benzodiazepines, which are considered first-line therapy for treating alcohol withdrawal syndrome (AWS). Which disease is the selected substance indicated for? | trigeminal neuralgia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00399","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Oxazepam interacts with multiple substances. One of these substances is characterized by cross-tolerance with benzodiazepines, which are considered f... | |
medium_divergent_branch_00400 | PRDX2 is associated with multiple biological processes. One association is supported by evidence stating: 'Peroxiredoxins are antioxidant enzymes involved in protein and lipid protection against oxidative injury and in cellular signalling pathways regulating apoptosis.' Which biological process, connected to the proces... | response to stress | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00400","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRDX2 is associated with multiple biological processes. One association is supported by evidence stating: 'Peroxiredoxins are antioxidant enzymes inv... | |
medium_divergent_branch_00401 | LRP5 is implicated in multiple biological processes. One specific connection is supported by evidence stating that LRP5 mutations and Wnt signaling levels determine the differentiation fate of human mesenchymal stem cells (hMSCs) into either osteoblasts or adipocytes. Which biological process, connected to the process ... | animal organ development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00401","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRP5 is implicated in multiple biological processes. One specific connection is supported by evidence stating that LRP5 mutations and Wnt signaling l... | |
medium_divergent_branch_00402 | The gene DNAH1 is associated with multiple biological processes. One specific process is linked to evidence stating that mutations in this axonemal inner dynein arm heavy chain gene cause male infertility characterized by MMAF (multiple morphological abnormalities of the sperm flagella), a condition defined by spermato... | flagellated sperm cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00402","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DNAH1 is associated with multiple biological processes. One specific process is linked to evidence stating that mutations in this axonemal i... | |
medium_divergent_branch_00403 | EIF5 is associated with multiple biological processes. One association is supported by evidence stating that interactions among translation initiation factors, including eIF1 and EIF5, govern start codon selection. Which broader biological category, defined by an 'is a' relationship, does this specific process belong t... | regulation of translation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00403","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF5 is associated with multiple biological processes. One association is supported by evidence stating that interactions among translation initiatio... | |
medium_divergent_branch_00404 | HSP90AB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that ATP caused exclusively local changes in Hsp90's N-terminal nucleotide-binding domain. Native mass spectrometry showed that Hsp90 and a co-chaperone protein form a complex via a positively cooperative mechanism.' ... | Prostaglandin E synthase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00404","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSP90AB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that ATP caused exclusively local changes in H... | |
medium_divergent_branch_00405 | HIF1AN interacts with multiple proteins. One interaction is supported by evidence stating: 'Purified [the protein encoded by the interacting partner gene] binds FIH-1 and inhibits the ability of FIH-1 to modify HIF-1alpha in vitro.' Which protein, connected to HIF1AN via this specific evidence, is the subject of the 'e... | Amyloid-beta A4 precursor protein-binding family A member 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00405","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIF1AN interacts with multiple proteins. One interaction is supported by evidence stating: 'Purified [the protein encoded by the interacting partner ... | |
medium_divergent_branch_00406 | L1CAM is associated with multiple biological processes. One association is supported by evidence stating: 'The nerve growth factor (NGF)-induced neurite outgrowth was re-established in defective clone cells transfected with the wild-type and the H210Q and I219T L1CAM mutants, but not in the others.' Which biological pr... | neuron development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00406","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"L1CAM is associated with multiple biological processes. One association is supported by evidence stating: 'The nerve growth factor (NGF)-induced neur... | |
medium_divergent_branch_00407 | The protein CLN5 is associated with multiple cellular components. One association is supported by evidence stating: 'Confocal immunofluorescence microscopy showed that wild-type CLN5 is predominantly targeted to lysosomes.' Which cellular component, connected to CLN5 via a 'located in' relationship, is described by thi... | lytic vacuole | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00407","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CLN5 is associated with multiple cellular components. One association is supported by evidence stating: 'Confocal immunofluorescence micr... | |
medium_divergent_branch_00410 | WNT4 is implicated in multiple biological processes. One specific connection is supported by evidence stating: 'We further show that SFRP2-expressing cells can reduce the dermomyotome-inducing activity of WNT1 and WNT4, but not that of WNT3a.' Identify the biological process that is positively regulated by the process ... | dermatome development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00410","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT4 is implicated in multiple biological processes. One specific connection is supported by evidence stating: 'We further show that SFRP2-expressing... | |
medium_divergent_branch_00412 | TRIM21 interacts with multiple proteins. One of these interaction partners facilitates the K63-linked ubiquitination of RIPK1 by recruiting TRIM21, which acts as the E3 ligase catalyzing this modification at residue K140 of RIPK1. Which gene encodes this specific interaction partner? | Pancreatic progenitor cell differentiation and proliferation factor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00412","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM21 interacts with multiple proteins. One of these interaction partners facilitates the K63-linked ubiquitination of RIPK1 by recruiting TRIM21, w... | |
medium_divergent_branch_00413 | The gene JUN is known to interact with multiple partners. One specific interaction partner is described as acting together with c-Jun and c-Fos to activate transcription in response to TGF-beta. This activation occurs through a TGF-beta-inducible association of c-Jun with this partner and an interaction between this pa... | SMAD family member 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00413","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene JUN is known to interact with multiple partners. One specific interaction partner is described as acting together with c-Jun and c-Fos to ac... | |
medium_divergent_branch_00414 | The insulin receptor (INSR) binds to multiple proteins. One of these binding partners is distinguished by the presence of an interaction domain spanning residues 591 to 786, a feature that is absent in IRS-1. Which gene product interacts with this specific binding partner? | USP15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00414","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The insulin receptor (INSR) binds to multiple proteins. One of these binding partners is distinguished by the presence of an interaction domain spann... | |
medium_divergent_branch_00415 | ABCA1 interacts with multiple proteins. One interaction is characterized by the finding that apoA-I-stimulated cholesterol efflux requires a direct interaction between the apoprotein and critical residues in two extracellular loops of ABCA1. Which protein, connected to ABCA1 via this specific interaction, is encoded by... | Apolipoprotein A-I | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00415","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCA1 interacts with multiple proteins. One interaction is characterized by the finding that apoA-I-stimulated cholesterol efflux requires a direct i... | |
medium_divergent_branch_00417 | RARA interacts with multiple genes. One specific interaction partner was isolated and shown to associate with retinoic acid (RA)-bound retinoic acid receptor (RAR) through the C-terminal nuclear hormone receptor (NR) box/LxxLL motif, thereby increasing RAR/RXR-mediated transcription. Which disease is linked to this spe... | nephrolithiasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00417","source_qa_id":"medium_divergent_branch_05162","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RARA interacts with multiple genes. One specific interaction partner was isolated and shown to as... | |
medium_divergent_branch_00418 | Extracellular matrix-secreting cells are components of multiple anatomical structures. One such structure is defined by evidence stating it is 'Dense regular connective tissue connecting two or more adjacent skeletal elements'. Which anatomical structure, composed of these cells, fits this description? | skeletal system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00418","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Extracellular matrix-secreting cells are components of multiple anatomical structures. One such structure is defined by evidence stating it is 'Dense... | |
medium_divergent_branch_00419 | SNAP25 interacts with multiple proteins. One interaction is supported by evidence stating that SNAP-25/Sec9p directly interact with ORP/Osh proteins, and their disruption destabilized the ORP/Osh proteins, associated with dysfunction of VAPA/Scs2p. Which protein, connected to SNAP25 via this specific interaction eviden... | Oxysterol-binding protein-related protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00419","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNAP25 interacts with multiple proteins. One interaction is supported by evidence stating that SNAP-25/Sec9p directly interact with ORP/Osh proteins,... | |
medium_divergent_branch_00420 | KCNJ12 interacts with multiple proteins. One interaction is supported by evidence showing that Kir2.x isoforms exhibit unique subcellular colocalization in human cardiomyocytes and coimmunoprecipitate with the interacting partner. Which protein is encoded by the gene that interacts with KCNJ12 in this specific context? | Caveolin-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00420","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNJ12 interacts with multiple proteins. One interaction is supported by evidence showing that Kir2.x isoforms exhibit unique subcellular colocalizat... | |
medium_divergent_branch_00421 | FN1 interacts with multiple proteins. One interaction is supported by evidence showing that Fibronectin coimmunoprecipitated with wild-type von Hippel-Lindau protein (pVHL) but not with tumor-derived pVHL mutants. Which protein, connected to FN1 via an interaction, is encoded by the gene associated with this specific e... | von Hippel-Lindau disease tumor suppressor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00421","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FN1 interacts with multiple proteins. One interaction is supported by evidence showing that Fibronectin coimmunoprecipitated with wild-type von Hippe... | |
medium_divergent_branch_00422 | The gene PKD1 is associated with multiple biological processes. One of these processes is supported by evidence indicating that high PKD1 expression first appears in differentiated proximal tubules. Which anatomical structure is the result of the development governed by this specific biological process? | metanephric proximal tubule | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00422","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PKD1 is associated with multiple biological processes. One of these processes is supported by evidence indicating that high PKD1 expression ... | |
medium_divergent_branch_00423 | NKX2-5 is associated with multiple biological processes. One association is supported by evidence stating: 'Our results indicate that Nkx2-5(-/-) embryos exhibit thyroid bud hypoplasia, providing evidence that NKX2-5 plays a role in thyroid organogenesis and that NKX2-5 mutations contribute to TD.' Which biological pro... | endocrine system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00423","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NKX2-5 is associated with multiple biological processes. One association is supported by evidence stating: 'Our results indicate that Nkx2-5(-/-) emb... | |
medium_divergent_branch_00424 | PATZ1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We show here that the RIalpha subunit interacts with a BTB/POZ domain zinc-finger transcription factor, PATZ1 (ZNF278), and co-expression with RIalpha results in its sequestration in the cytoplasm.' Which disease is connect... | neonatal severe primary hyperparathyroidism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00424","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PATZ1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We show here that the RIalpha subunit interacts with... | |
medium_divergent_branch_00425 | FFAR2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that FFA2 is a G protein-coupled receptor responding to short-chain fatty acids, highlighting its role as a therapeutic target for metabolic and inflammatory conditions. Which ... | transmembrane signaling receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00425","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FFAR2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that ... | |
medium_divergent_branch_00426 | WDR48 interacts with multiple proteins. One of these interaction partners is a WD40 repeat-containing protein that interacts with USP12 and is required for histone deubiquitination activity. Which disease is associated with this specific interaction partner via a biomarker relationship? | major depressive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00426","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WDR48 interacts with multiple proteins. One of these interaction partners is a WD40 repeat-containing protein that interacts with USP12 and is requir... | |
medium_divergent_branch_00429 | The entity 'carpus cartilage element' is a subclass of two distinct anatomical structures. One of these parent structures is defined as a cartilaginous condensation with the potential to develop into a carpal bone. Which anatomical region is the parent structure that matches this definition a part of? | carpal region | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00429","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The entity 'carpus cartilage element' is a subclass of two distinct anatomical structures. One of these parent structures is defined as a cartilagino... | |
medium_divergent_branch_00430 | The UBD domain interacts with multiple genes. One of these interaction partners is described in evidence stating that FAT10 non-covalently associates with its 2CARD domain, thereby inhibiting viral RNA-induced IRF3 and NF-kB activation by modulating the protein's solubility. Which disease is associated with this specif... | Squamous cell carcinoma of the head and neck | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00430","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The UBD domain interacts with multiple genes. One of these interaction partners is described in evidence stating that FAT10 non-covalently associates... | |
medium_divergent_branch_00431 | The subcommissural organ is anatomically connected to a specific structure via a 'part of' relationship. Evidence indicates that the subcommissural organ is a circumventricular organ consisting of ependymal and hypendymal cells which secrete SCO-spondin. Which structure is the subcommissural organ a part of? | midbrain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00431","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The subcommissural organ is anatomically connected to a specific structure via a 'part of' relationship. Evidence indicates that the subcommissural o... | |
medium_divergent_branch_00432 | EPRS1 interacts with multiple proteins. One specific interaction is supported by evidence stating that tandem repeats in the human bifunctional glutamyl-prolyl-tRNA synthetase (EPRS) interact with distinct repeated motifs in human isoleucyl-tRNA synthetase. Which protein, encoded by the gene connected to EPRS1 via this... | Isoleucine--tRNA ligase, cytoplasmic | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00432","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPRS1 interacts with multiple proteins. One specific interaction is supported by evidence stating that tandem repeats in the human bifunctional gluta... | |
medium_divergent_branch_00433 | The gene JUP interacts with multiple partners. One specific interaction partner is characterized by evidence stating: 'The importance of the [partner]-ErbB2 interaction is supported by the demonstration that HRG induces binding of the [partner] and gamma-catenin and targeting of the [partner]-gamma-catenin complex to t... | female infertility | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00433","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene JUP interacts with multiple partners. One specific interaction partner is characterized by evidence stating: 'The importance of the [partner... | |
medium_divergent_branch_00434 | FKBP8 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We recently reported that the FK506-binding protein (FKBP) 38 specifically interacts with a prolyl hydroxylase domain protein and determines its protein stability in a peptidyl-prolyl cis-trans isomerase-independent mann... | Egl nine homolog 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00434","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FKBP8 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We recently reported that the FK506-binding prote... | |
medium_divergent_branch_00436 | FGF10 is associated with multiple biological processes. One association is supported by evidence that recombinant human FGF-10 induces the proliferation of human urothelial cells in vitro and the transitional epithelium of wild-type and FGF7-null mice in vivo. Which biological process, connected to the process supporte... | urothelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00436","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF10 is associated with multiple biological processes. One association is supported by evidence that recombinant human FGF-10 induces the proliferat... | |
medium_divergent_branch_00437 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.264 and an adjusted p-value of 0.0146. For which disease is that selected gene recorded as a biomarker? | squamous cell carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00437","source_qa_id":"medium_divergent_branch_02247","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_00438 | TNKS2 interacts with multiple proteins. One of these interaction partners is described in structural and biochemical studies as acting as an optimal substrate decoy that potently hijacks substrate binding sites on TNKS1 to prevent AXIN1 PARylation and degradation. Which protein is encoded by the gene corresponding to t... | P antigen family member 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00438","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNKS2 interacts with multiple proteins. One of these interaction partners is described in structural and biochemical studies as acting as an optimal ... | |
medium_divergent_branch_00439 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.667 and an adjusted p-value of 0.0459. Which protein does that selected gene encode? | Protein-cysteine N-palmitoyltransferase HHAT-like protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00439","source_qa_id":"medium_divergent_branch_03267","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_00441 | The transcription factor SP3 interacts with multiple proteins. One specific interaction partner is described in the following evidence: 'We identified the protein inhibitor of activated STAT1 as an interaction partner of SP3 and Ubc9.' Which protein is encoded by the gene corresponding to this interaction partner? | E3 SUMO-protein ligase PIAS1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00441","source_qa_id":"medium_divergent_branch_06716","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The transcription factor SP3 interacts with multiple proteins. One specific interaction partner i... | |
medium_divergent_branch_00442 | ABCA12 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'We concluded that ABCA12 works as an epidermal keratinocyte lipid transporter.' Which molecular function, connected to this specific function via an 'is_a' relationship, rep... | transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00442","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCA12 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'We... | |
medium_divergent_branch_00443 | RNPS1 interacts with multiple genes. One of these interaction partners is stabilized by RNPS1, which inhibits its ubiquitination-mediated degradation by the E3 ubiquitin ligase ZSWIM6 through direct protein interaction, thereby promoting high expression of this partner in head and neck squamous cell carcinoma (HNSCC). ... | THUMPD1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00443","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNPS1 interacts with multiple genes. One of these interaction partners is stabilized by RNPS1, which inhibits its ubiquitination-mediated degradation... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.