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medium_divergent_branch_00558 | KIF14 is associated with multiple biological processes. One association is supported by evidence stating that knockdown of KIF14 resulted in suppression of cell proliferation and failure of cytokinesis, whereas overexpression increased cell proliferation. Which biological process, connected to KIF14 via an 'involved in... | cell growth | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00558","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF14 is associated with multiple biological processes. One association is supported by evidence stating that knockdown of KIF14 resulted in suppress... | |
medium_divergent_branch_00560 | CUX1 interacts with multiple proteins. One of these interaction partners was shown to bind CDP via its DNA-binding domain, as demonstrated by glutathione S-transferase (GST) pull-down assays. Which gene encodes this specific interaction partner? | DNA-binding protein SATB1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00560","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUX1 interacts with multiple proteins. One of these interaction partners was shown to bind CDP via its DNA-binding domain, as demonstrated by glutath... | |
medium_divergent_branch_00561 | RACGAP1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We have isolated B56epsilon, a PP2A regulatory subunit, as a new MgcRacGAP partner.' Which disease is associated with the gene identified in this specific interaction through genomic alterations? | soft tissue sarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00561","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RACGAP1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We have isolated B56epsilon, a PP2A regulatory sub... | |
medium_divergent_branch_00562 | KIFAP3 interacts with multiple proteins. One interaction is supported by evidence stating that a specific mitogen-activated protein kinase kinase kinase and MLK3 interact with members of the KIF3 family of kinesin superfamily motor proteins and with KAP3A, the putative targeting component of KIF3 motor complexes, sugge... | Mitogen-activated protein kinase kinase kinase 10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00562","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIFAP3 interacts with multiple proteins. One interaction is supported by evidence stating that a specific mitogen-activated protein kinase kinase kin... | |
medium_divergent_branch_00563 | CCDC50 is reported to interact with multiple genes. One specific interaction is supported by evidence stating: 'Using a yeast two-hybrid system to search for proteins interacting with a specific target protein, we identified one novel binding protein, Ymer.' Which cell type is enriched in the gene identified by this sp... | mucosal-associated invariant T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00563","source_qa_id":"medium_divergent_branch_06486","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CCDC50 is reported to interact with multiple genes. One specific interaction is supported by evid... | |
medium_divergent_branch_00564 | MAP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'The samples were immunoprecipitated with anti-alpha- and anti-beta-tubulin antibodies and reblotted with an anti-MAP2 antibody, which showed that the amount of co-immuno-precipitated MAP2 in the synchronized cells, were increased ... | scoliosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00564","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'The samples were immunoprecipitated with anti-alpha- and an... | |
medium_divergent_branch_00565 | The gene C12orf57 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data strongly implicate mutations in C12orf57 in the pathogenesis of a clinically distinct autosomal-recessive syndromic form of colobomatous microphthalmia.' Which anatomical structure is the resu... | camera-type eye | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00565","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene C12orf57 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data strongly implicate mu... | |
medium_divergent_branch_00566 | hsa-miR-142-3p regulates more than one cell type. Evidence for one of these regulatory connections notes that miR-142-3p expression is abnormally low in the selected cell type from patients with the most proliferative forms of chronic myelomonocytic leukemia (CMML), and that re-expression of miR-142-3p in these dysplas... | promonocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00566","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-142-3p regulates more than one cell type. Evidence for one of these regulatory connections notes that miR-142-3p expression is abnormally low... | |
medium_divergent_branch_00568 | REP15 interacts with multiple genes. One of these interactions is supported by biochemical validation and crystal structures of the Rep15:Rab3B and Rep15:Rab3C complexes, which provide additional mechanistic insight. Which disease is associated with the gene that interacts with REP15 in this context? | cocaine dependence | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00568","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"REP15 interacts with multiple genes. One of these interactions is supported by biochemical validation and crystal structures of the Rep15:Rab3B and R... | |
medium_divergent_branch_00569 | SH3BP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that Tankyrase, a member of the poly(ADP-ribose)polymerase (PARP) family, regulates 3BP2 stability through ADP-ribosylation and subsequent ubiquitylation by the E3-ubiquitin ligase RNF146 in osteoclasts.' Which prot... | Poly [ADP-ribose] polymerase tankyrase-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00569","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SH3BP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that Tankyrase, a member of the poly(ADP-rib... | |
medium_divergent_branch_00570 | DLGAP4 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using the PDZ domains of ProSAP1 and 2 as bait in the yeast two-hybrid system, we isolated several clones of the SAPAP/GKAP (SAP90/PSD-95-associated protein/guanylate kinase-associated protein) family.' Which protein, e... | SH3 and multiple ankyrin repeat domains protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00570","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLGAP4 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using the PDZ domains of ProSAP1 and 2 as bait i... | |
medium_divergent_branch_00571 | USP22 interacts with multiple proteins. One specific interaction involves a partner protein whose C-terminus is directly bound by USP22, leading to the partner's deubiquitination and stabilization. Which protein is encoded by the gene corresponding to this specific interaction partner? | Programmed cell death 1 ligand 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00571","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP22 interacts with multiple proteins. One specific interaction involves a partner protein whose C-terminus is directly bound by USP22, leading to t... | |
medium_divergent_branch_00572 | The gene COPS4 interacts with multiple other genes. One of these interactions is supported by evidence stating: 'Interestingly, immunoprecipitation experiments showed that the protein encoded by the interacting gene is found in the CSN4-sGCα1 cytoplasmic protein complex.' Which protein is encoded by the gene that inter... | Cellular tumor antigen p53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00572","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene COPS4 interacts with multiple other genes. One of these interactions is supported by evidence stating: 'Interestingly, immunoprecipitation e... | |
medium_divergent_branch_00573 | KAT2B interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report the identification of TRIP-Br3 as a member of the TRIP-Br family along with evidence showing that TRIP-Brs interact with bromodomain-containing transcriptional cofactors PCAF, STAF65gamma, and KAP1.' Another intera... | SERTA domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00573","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KAT2B interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report the identification of TRIP-Br3 as a member ... | |
medium_divergent_branch_00574 | The gene RASD2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here we show that Rhes interacts with the regulatory subunit of PI3K.' Which protein is encoded by the gene that corresponds to this specific interaction partner? | Phosphatidylinositol 3-kinase regulatory subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00574","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RASD2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here we show that Rhes interacts with th... | |
medium_divergent_branch_00575 | BAX interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show by immunoprecipitation-using a battery of commercially available, monoclonal antibodies-that the protein encoded by the BCL2 gene binds Bax in nuclei of human breast cancer cells.' Which protein is encoded by ... | Apoptosis regulator Bcl-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00575","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAX interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show by immunoprecipitation-using a battery... | |
medium_divergent_branch_00577 | STAT6 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Furthermore, we show that cotransfection of STAT6 and this partner induces an interaction between the two proteins, consequently forming a complex that subsequently translocates into the nucleus and up-regulates the tran... | Lipopolysaccharide-induced tumor necrosis factor-alpha factor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00577","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STAT6 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Furthermore, we show that cotransfection of STAT6... | |
medium_divergent_branch_00578 | CCL28 is associated with multiple biological processes. One of these associations is supported by evidence that CCL28 exhibits potent antimicrobial activity against Candida albicans, Gram-negative bacteria, and Gram-positive bacteria in human and mouse models. Which broader biological process is the specific process li... | antimicrobial humoral response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00578","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCL28 is associated with multiple biological processes. One of these associations is supported by evidence that CCL28 exhibits potent antimicrobial a... | |
medium_divergent_branch_00579 | NEDD4L interacts with multiple proteins. One specific interaction is characterized by the following mechanism: Through its WW domain, the interacting partner specifically recognizes a TGF-beta-induced phosphoThr-ProTyr motif in the linker region, resulting in the polyubiquitination and degradation of Smad2/3. Which dis... | aneurysm-osteoarthritis syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00579","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NEDD4L interacts with multiple proteins. One specific interaction is characterized by the following mechanism: Through its WW domain, the interacting... | |
medium_divergent_branch_00580 | OST4 interacts with multiple genes via protein-protein binding. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies suggest that OST4 associates with both STT3 isoforms and with ribophorin I, an accessory subunit of mammalian OSTs.' Which gene is directly connected to the STT3 isoform iden... | TMEM258 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00580","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OST4 interacts with multiple genes via protein-protein binding. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies sug... | |
medium_divergent_branch_00581 | VPS33A is involved in multiple biological processes. One of these processes is supported by evidence stating: 'In contrast, VPS33A induced significantly more clustering of melanosomes in melanoma cells than VPS33B.' Which cellular component serves as the primary input for this specific biological process? | melanosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00581","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS33A is involved in multiple biological processes. One of these processes is supported by evidence stating: 'In contrast, VPS33A induced significan... | |
medium_divergent_branch_00582 | DNMT3A interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we have determined the crystal structures of the ATRX-DNMT3-DNMT3L (ADD) domain of DNMT3A in an unliganded form and in a complex with the amino-terminal tail of histone H3.' Which protein, among those interacting with DNMT... | Histone H3.1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00582","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNMT3A interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we have determined the crystal structures of the AT... | |
medium_divergent_branch_00583 | The gene MYH6 is associated with multiple biological processes. One specific association is supported by evidence showing that Morpholino knock-down of the chick MYH6 homolog eliminates the formation of the atrial septum without overtly affecting atrial chamber formation. Which biological process, connected to the proc... | cardiac muscle tissue morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00583","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MYH6 is associated with multiple biological processes. One specific association is supported by evidence showing that Morpholino knock-down ... | |
medium_divergent_branch_00584 | The gene IL6ST interacts with multiple partners. One interaction is characterized by the recruitment of a Src homology domain containing tyrosine phosphatase to the receptor subunit gp130 upon stimulation of the IL-6R complex, followed by the phosphatase's tyrosine phosphorylation. Which protein is encoded by the gene ... | Tyrosine-protein phosphatase non-receptor type 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00584","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL6ST interacts with multiple partners. One interaction is characterized by the recruitment of a Src homology domain containing tyrosine pho... | |
medium_divergent_branch_00585 | FOXO3 interacts with multiple proteins. One interaction was identified using HeLa cancer cells via Tandem Affinity Purification followed by Mass Spectrometry, which revealed a specific kinase as a binding partner of FOXO3. Which protein, connected to FOXO3 through this specific interaction evidence, is the subject of t... | Serine/threonine-protein kinase PLK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00585","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXO3 interacts with multiple proteins. One interaction was identified using HeLa cancer cells via Tandem Affinity Purification followed by Mass Spec... | |
medium_divergent_branch_00586 | DPYSL2 interacts with multiple genes. One of these interacting partners undergoes H2O2-dependent oxidation, leading to the formation of a mixed disulfide with CRMP2, a process reversed by thioredoxin. Which disease is associated with this specific interacting gene through genomic alterations? | Gerstmann-Straussler-Scheinker syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00586","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DPYSL2 interacts with multiple genes. One of these interacting partners undergoes H2O2-dependent oxidation, leading to the formation of a mixed disul... | |
medium_divergent_branch_00587 | Sensory perception of smell is associated with multiple anatomical structures. One such structure is described as the olfactory organ of vertebrates, consisting of nares, olfactory epithelia, and the structures and skeletal framework of the nasal cavity. Which anatomical structure is this specific entity a part of? | face | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00587","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Sensory perception of smell is associated with multiple anatomical structures. One such structure is described as the olfactory organ of vertebrates,... | |
medium_divergent_branch_00588 | Purkinje myocytes are part of two anatomical structures. One is described as a component of the cardiac conduction system that receives signals from the bundle of His and innervates ventricular cardiac muscle. Starting from the structure that best matches this description, which anatomical structure does it contribute ... | conducting system of heart | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00588","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Purkinje myocytes are part of two anatomical structures. One is described as a component of the cardiac conduction system that receives signals from ... | |
medium_divergent_branch_00589 | MRPL51 is associated with multiple cellular components via 'located in' relationships. One line of evidence describes Oxa1L-CTT cross-links to mammalian mitochondrial homologs of bacterial ribosomal proteins L13, L20, and L28, as well as to mammalian mitochondrial-specific ribosomal proteins MRPL48, MRPL49, and MRPL51.... | organellar ribosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00589","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MRPL51 is associated with multiple cellular components via 'located in' relationships. One line of evidence describes Oxa1L-CTT cross-links to mammal... | |
medium_divergent_branch_00592 | The APOB protein interacts with multiple partners. One specific interaction partner is distinguished by evidence showing that the Cys-1085Ser mutation in apoB-29 significantly reduces its association with this partner compared to the wild-type form. Which disease is associated with this specific interaction partner via... | gastric cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00592","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The APOB protein interacts with multiple partners. One specific interaction partner is distinguished by evidence showing that the Cys-1085Ser mutatio... | |
medium_divergent_branch_00593 | JAMP interacts with multiple proteins. One interaction is supported by evidence stating: 'This ubiquitination does not alter JAMP stability but rather inhibits its association with the protein encoded by the gene interacting with JAMP and p97.' Which protein, encoded by the gene involved in this specific interaction, i... | 26S proteasome regulatory subunit 6A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00593","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JAMP interacts with multiple proteins. One interaction is supported by evidence stating: 'This ubiquitination does not alter JAMP stability but rathe... | |
medium_divergent_branch_00597 | HNF4A interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we showed, using a yeast two-hybrid screening assay, that thyroid hormone receptor interacting protein 3 interacted with HNF-4alpha, and their interaction was confirmed by the glutathione S-transferase pull-... | Zinc finger HIT domain-containing protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00597","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HNF4A interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we showed, using a yeast two-hybrid ... | |
medium_divergent_branch_00598 | RAD51 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using the yeast two-hybrid system, we isolated a cDNA encoding a novel human protein, named [a specific RAD51-interacting protein], that strongly interacts with human Rad51 recombinase.' Which protein, connected to RAD51 via this... | RAD51-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00598","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD51 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using the yeast two-hybrid system, we isolated a cDNA enco... | |
medium_divergent_branch_00599 | The REST protein interacts with multiple genes. One specific interaction partner forms complexes with REST that are readily detected by coimmunoprecipitation assays and are localized to aggregated PML-nuclear bodies in undifferentiated pluripotent human NTera2 stem cells. Which disease is associated with this specific ... | adult T-cell leukemia/lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00599","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The REST protein interacts with multiple genes. One specific interaction partner forms complexes with REST that are readily detected by coimmunopreci... | |
medium_divergent_branch_00600 | NDRG1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Further analyses, focusing on apolipoproteins A-I and A-II, confirmed their interaction with NDRG1 in mammalian cells.' Which protein is encoded by the gene that interacts with NDRG1 according to this specific evidence? | Apolipoprotein A-I | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00600","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NDRG1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Further analyses, focusing on apolipoproteins A-I a... | |
medium_divergent_branch_00601 | ETAA1 interacts with multiple proteins. One of these interaction partners is characterized by specific binding to Replication Protein A (RPA) through two conserved RPA-binding domains. Which protein corresponds to this interaction partner? | Replication protein A 14 kDa subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00601","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ETAA1 interacts with multiple proteins. One of these interaction partners is characterized by specific binding to Replication Protein A (RPA) through... | |
medium_divergent_branch_00603 | ATF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report here that a specific co-activator of CREB, which was originally identified as such, directly binds to the b-ZIP region of ATF-2 via a Cys/His-rich region termed C/H2, and potentiates trans-activation by ATF-2.' Which pro... | CREB-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00603","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report here that a specific co-activator of CREB, which ... | |
medium_divergent_branch_00605 | The MNT protein interacts with multiple partners. One specific interaction is supported by evidence stating that the proteins physically associate with each other in both non-myeloid (HEK293T) and myeloid cells. Which gene, connected to MNT via this specific interaction, is subsequently linked to another gene through a... | ZNFX1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00605","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The MNT protein interacts with multiple partners. One specific interaction is supported by evidence stating that the proteins physically associate wi... | |
medium_divergent_branch_00606 | The biological process 'positive regulation of natural killer cell differentiation' is defined as any process that activates or increases the frequency, rate, or extent of natural killer cell differentiation. This process is a subtype of another biological process. Which biological process is positively regulated by th... | lymphocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00606","source_qa_id":"medium_divergent_branch_00214","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'positive regulation of natural killer cell differentiation' is defined as... | |
medium_divergent_branch_00607 | Perivascular macrophages are anatomically associated with a specific structure via a 'part of' relationship. One such association is supported by evidence describing a border-associated macrophage adjacent to a small instance of this structure within the brain. This macrophage expresses CD14, CD16, and CD163 markers. U... | blood vasculature | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00607","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Perivascular macrophages are anatomically associated with a specific structure via a 'part of' relationship. One such association is supported by evi... | |
medium_divergent_branch_00609 | The gene TOR1A interacts with multiple other genes. One specific interaction is supported by immunoprecipitation studies in cultured cells and human brain tissue, which indicate that torsinA and torsinB are associated with each other in cells. Which protein is encoded by the gene that interacts with TOR1A in this speci... | Torsin-1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00609","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TOR1A interacts with multiple other genes. One specific interaction is supported by immunoprecipitation studies in cultured cells and human ... | |
medium_divergent_branch_00610 | MORF4L1 interacts with multiple proteins. One interaction partner is distinguished by evidence stating that MRFAP1 binds to E3 ubiquitin ligases such as CUL4B, but does not bind to components of the NuA4 complex, specifically including this partner, which in turn binds to MORF4L1. Which protein is encoded by the gene c... | MRG/MORF4L-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00610","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MORF4L1 interacts with multiple proteins. One interaction partner is distinguished by evidence stating that MRFAP1 binds to E3 ubiquitin ligases such... | |
medium_divergent_branch_00611 | The gene ALB is linked via a binding interaction to multiple other genes. One piece of evidence states: 'We show here that albumin binds a neonatal Fc receptor in a pH dependent fashion.' Which protein is encoded by the gene connected to ALB through this binding interaction? | IgG receptor FcRn large subunit p51 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00611","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ALB is linked via a binding interaction to multiple other genes. One piece of evidence states: 'We show here that albumin binds a neonatal F... | |
medium_divergent_branch_00612 | TWIST1 is involved in multiple biological processes. One of these processes is supported by evidence that silencing TWIST1 downregulates the expression and secretion of inflammatory factors, including tumor necrosis factor-alpha, interleukin-6, and monocyte chemoattractant protein-1. Which biological process, connected... | tumor necrosis factor production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00612","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TWIST1 is involved in multiple biological processes. One of these processes is supported by evidence that silencing TWIST1 downregulates the expressi... | |
medium_divergent_branch_00613 | LGALS1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'We have determined that galectin-1 binds to a restricted set of T cell surface glycoproteins, and that only CD45, a specific glycoprotein, and CD7 appear to directly participate in galectin-1-induced apoptosis.' Which gen... | SIGLEC1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00613","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LGALS1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'We have determined that galectin-1 binds to a rest... | |
medium_divergent_branch_00614 | KCNA5 interacts with multiple proteins. One specific interaction involves a highly hydrophobic domain (FQRQVWLLF) that binds to a partner protein, thereby targeting the Kv1.3 channel to caveolar rafts. Which protein is encoded by the gene corresponding to this specific interaction partner? | Caveolin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00614","source_qa_id":"medium_divergent_branch_00215","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"KCNA5 interacts with multiple proteins. One specific interaction involves a highly hydrophobic do... | |
medium_divergent_branch_00616 | LILRB1 is associated with multiple biological processes. One association is supported by evidence stating that continuous ligation of LILRB1 modulated cellular differentiation, conferred a unique phenotype upon the resultant cells, induced a profound resistance to CD95-mediated cell death, and inhibited the secretion o... | cytokine production involved in immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00616","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LILRB1 is associated with multiple biological processes. One association is supported by evidence stating that continuous ligation of LILRB1 modulate... | |
medium_divergent_branch_00617 | RBCK1 interacts with multiple genes. One of these interaction partners is identified by evidence stating that HOIL-1, an ubiquitin-protein ligase which recognizes heme-bound, oxidized iron regulatory protein 2, was found to bind with this partner when both were overexpressed in NIH 3T3 cells. Which cell type is the gen... | neutrophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00617","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBCK1 interacts with multiple genes. One of these interaction partners is identified by evidence stating that HOIL-1, an ubiquitin-protein ligase whi... | |
medium_divergent_branch_00618 | UBXN1 interacts with multiple genes. One specific interaction is supported by evidence stating that three family members, including the interacting partner, N9, and N11, blocked the canonical NFκB pathway by binding to a cullin protein, thereby inhibiting IκBα degradation. Which disease is associated with this specific... | malignant pleural mesothelioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00618","source_qa_id":"medium_divergent_branch_05362","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"UBXN1 interacts with multiple genes. One specific interaction is supported by evidence stating th... | |
medium_divergent_branch_00619 | The gene PCGF5 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 110.10 TPM, a z-score of 2.29, and a fold enrichment of 3.88. Which cell type does this specific cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00619","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PCGF5 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 110.10 TPM, a z-score of 2.29, and a fold en... | |
medium_divergent_branch_00620 | In a study of Human mastadenovirus C infection in lung fibroblasts (GSE120891), one downregulated gene exhibits a log2 fold change of approximately -1.16 and an adjusted p-value of 0.0381. Which disease is associated with this specific gene? | cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00620","source_qa_id":"medium_divergent_branch_01218","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"In a study of Human mastadenovirus C infection in lung fibroblasts (GSE120891), one downregulated... | |
medium_divergent_branch_00621 | CD9 is associated with multiple biological processes. One of these associations is supported by evidence that CD9 modulates PDGFR signaling, a mechanism evolutionarily conserved from Drosophila glia to human glioma that facilitates glial migration. Which biological process, connected to this specific CD9-associated pro... | gliogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00621","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD9 is associated with multiple biological processes. One of these associations is supported by evidence that CD9 modulates PDGFR signaling, a mechan... | |
medium_divergent_branch_00622 | SFPQ interacts with multiple genes. One interaction is supported by evidence stating: 'Here we identified by proteomic approach that the PTB-associated splicing factor (PSF) interacts with this gene.' Which disease is associated with this gene via a biomarker relationship? | scleroderma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00622","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SFPQ interacts with multiple genes. One interaction is supported by evidence stating: 'Here we identified by proteomic approach that the PTB-associat... | |
medium_divergent_branch_00623 | PPP2R3B interacts with multiple genes. One of these interaction partners is specifically described as binding to an amino-terminal segment of the partner protein via PR48 and forming functional holoenzyme complexes with the A and C subunits of PP2A. Which disease is associated with this specific interaction partner? | Meier-Gorlin syndrome 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00623","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPP2R3B interacts with multiple genes. One of these interaction partners is specifically described as binding to an amino-terminal segment of the par... | |
medium_divergent_branch_00624 | CCNF interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a mode of substrate binding distinct from other F-box protein-substrate pairs, the protein encoded by the gene in question and Cyclin F physically associate on the centrioles during the G2 phase of the cell cycle, and the pr... | Centriolar coiled-coil protein of 110 kDa | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00624","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCNF interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a mode of substrate binding distinct from other F-box... | |
medium_divergent_branch_00625 | VPS18 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using biochemical techniques, we demonstrate that the zinc-containing RING (really interesting new gene) domains of human VPS18 and [Partner Protein] interact directly to form a stable heterodimer.' Which protein is the ... | Vacuolar protein sorting-associated protein 41 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00625","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS18 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using biochemical techniques, we demonstrate that... | |
medium_divergent_branch_00626 | The protein CGGBP1 is annotated with multiple molecular functions. One specific function is supported by evidence indicating that CGGBP1 acts as a cooperator of histone-modifying enzymes and is a component of CTCF-containing complexes that regulate enhancer-promoter looping. What is the parent molecular function (conne... | transcription factor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00626","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CGGBP1 is annotated with multiple molecular functions. One specific function is supported by evidence indicating that CGGBP1 acts as a co... | |
medium_divergent_branch_00627 | SYNRG interacts with multiple genes. One interaction is supported by evidence stating: 'Yeast two-hybrid analysis showed that the AGEH domains of the GGA proteins as well as those of gamma-adaptins are able to interact with gamma-synergin, which was previously shown to localized in the TGN region and interact with gamm... | AP1M1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00627","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SYNRG interacts with multiple genes. One interaction is supported by evidence stating: 'Yeast two-hybrid analysis showed that the AGEH domains of the... | |
medium_divergent_branch_00628 | FOXP1 is associated with multiple biological processes. One association is supported by evidence stating that silencing FOXP1 results in a strong inhibition of proliferation, tube formation, and migration of cultured endothelial cells. Which biological process, connected to the process supported by this evidence, is th... | endothelial cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00628","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXP1 is associated with multiple biological processes. One association is supported by evidence stating that silencing FOXP1 results in a strong inh... | |
medium_divergent_branch_00629 | APBB1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'The neuronal protein FE65 functions in brain development and amyloid precursor protein (APP) signaling through its interaction with the mammalian enabled protein and APP, respectively.' Which cellular component is the gene... | focal adhesion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00629","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APBB1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'The neuronal protein FE65 functions in brain develo... | |
medium_divergent_branch_00630 | SIRT6 interacts with multiple proteins. One of these interaction partners is described in the literature as also interacting with the 9-1-1 checkpoint clamp. Which protein, encoded by the gene connected to SIRT6 via this specific interaction, is the subject of this description? | Cell cycle checkpoint control protein RAD9A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00630","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIRT6 interacts with multiple proteins. One of these interaction partners is described in the literature as also interacting with the 9-1-1 checkpoin... | |
medium_divergent_branch_00633 | GJA1 interacts with multiple proteins. One specific interaction is supported by evidence showing that a 75 kDa protein interacts with endoplasmic reticulum-localized Cx43, as demonstrated through co-immunoprecipitation and immunofluorescence microscopy experiments. Which protein is encoded by the gene corresponding to ... | Ubiquilin-4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00633","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GJA1 interacts with multiple proteins. One specific interaction is supported by evidence showing that a 75 kDa protein interacts with endoplasmic ret... | |
medium_divergent_branch_00634 | SEMA4D is associated with multiple biological processes. One association is supported by evidence stating: 'We found that osteoclasts express semaphorin 4D, previously shown to be an axon guidance molecule, which potently inhibits bone formation.' Which biological process, connected to the process described in this evi... | ossification | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00634","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SEMA4D is associated with multiple biological processes. One association is supported by evidence stating: 'We found that osteoclasts express semapho... | |
medium_divergent_branch_00635 | SVIL interacts with multiple genes. Evidence indicates that GST fusions of the supervillin G2-G3 repeats co-sediment with this interaction partner, consistent with a direct association. Which disease is connected to this gene through genomic alterations? | autosomal recessive primary microcephaly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00635","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SVIL interacts with multiple genes. Evidence indicates that GST fusions of the supervillin G2-G3 repeats co-sediment with this interaction partner, c... | |
medium_divergent_branch_00636 | TRIP6 interacts with multiple proteins. One of these interacting partners is reported to regulate TRIP6 stability by influencing its ubiquitination, thereby affecting the Wnt signaling pathway. Which protein corresponds to this specific interacting partner? | Tripartite motif-containing protein 55 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00636","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIP6 interacts with multiple proteins. One of these interacting partners is reported to regulate TRIP6 stability by influencing its ubiquitination, ... | |
medium_divergent_branch_00637 | PDGFA interacts with multiple proteins. One specific interaction is described by the following evidence: 'The expressed protein was shown to display high-affinity binding of all three 125I-labeled dimeric forms of PDGF A and B chains in a manner that is characteristic for the PDGF A-type receptor.' Which protein, encod... | Platelet-derived growth factor receptor alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00637","source_qa_id":"medium_divergent_branch_03314","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PDGFA interacts with multiple proteins. One specific interaction is described by the following ev... | |
medium_divergent_branch_00638 | EHMT2 interacts with multiple genes. One of these interacting partners contains a SANT domain that binds to the histone methyltransferase G9a, and both its ELM2 and SANT domains orchestrate molecular events leading to stable methylation of histone H3-lysine 9. Which disease is associated with this specific interacting ... | myeloid leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00638","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EHMT2 interacts with multiple genes. One of these interacting partners contains a SANT domain that binds to the histone methyltransferase G9a, and bo... | |
medium_divergent_branch_00639 | SIPA1L3 is associated with multiple biological processes. One association is supported by evidence that Sipa1l3(-/-) mice exhibit disrupted epithelial cell organization and polarity. Which biological process, connected to the process implicated by this evidence via an 'is a' relationship, is the correct target? | establishment of cell polarity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00639","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIPA1L3 is associated with multiple biological processes. One association is supported by evidence that Sipa1l3(-/-) mice exhibit disrupted epithelia... | |
medium_divergent_branch_00640 | The protein ARNT forms a heterodimer with a specific HIF-alpha isoform. Evidence indicates that the C-terminal PAS domains of this isoform (identified as HIF-2alpha) and ARNT interact in vitro, and that mutations in the solvent-exposed beta-sheet surface of the HIF-2alpha domain disrupt this interaction and attenuate t... | Endothelial PAS domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00640","source_qa_id":"medium_divergent_branch_06776","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein ARNT forms a heterodimer with a specific HIF-alpha isoform. Evidence indicates that t... | |
medium_divergent_branch_00641 | GLI1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Herein, we demonstrate that IKKβ phosphorylates GLI1 in DLBCL.' Which protein is encoded by the gene corresponding to this interacting partner? | Inhibitor of nuclear factor kappa-B kinase subunit beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00641","source_qa_id":"medium_divergent_branch_01276","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GLI1 interacts with multiple proteins. One specific interaction is supported by evidence stating:... | |
medium_divergent_branch_00642 | FBXW11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Intriguingly, the betaTrCP homodimer, but not the heterodimer, was selectively recruited to pIkappaBalpha induced by TNF-alpha.' Which protein product is encoded by the gene corresponding to this specific interaction partner? | NF-kappa-B inhibitor alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00642","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXW11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Intriguingly, the betaTrCP homodimer, but not the heterod... | |
medium_divergent_branch_00643 | PINK1 interacts with multiple proteins. One interaction is supported by evidence describing the unbiased identification and confirmation of a mitochondrial multiprotein complex containing PINK1, the atypical GTPase Miro, and the adaptor protein Milton. Which protein, connected to PINK1 via this specific interaction, is... | Mitochondrial Rho GTPase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00643","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PINK1 interacts with multiple proteins. One interaction is supported by evidence describing the unbiased identification and confirmation of a mitocho... | |
medium_divergent_branch_00644 | The gene CISH interacts with multiple partners. One interaction is supported by evidence stating: 'We now show that IL-7 induces the expression of suppressor of cytokine signaling (SOCS) proteins CIS, SOCS1 and SOCS2 through the JAK/STAT-5 pathway and that CIS and SOCS2 specifically interact with the IL-7 receptor alph... | Interleukin-7 receptor subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00644","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CISH interacts with multiple partners. One interaction is supported by evidence stating: 'We now show that IL-7 induces the expression of su... | |
medium_divergent_branch_00646 | NRP2 is associated with multiple biological processes. One association is supported by evidence stating that characterizing specific isoforms helps elucidate the function of NRPs in neuronal guidance and a particular process. Which biological process is a parent term (is_a) of this particular process? | anatomical structure formation involved in morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00646","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NRP2 is associated with multiple biological processes. One association is supported by evidence stating that characterizing specific isoforms helps e... | |
medium_divergent_branch_00647 | RSPO4 interacts with multiple proteins. One interaction is supported by evidence stating: 'The RSPOs bound the LRR1-14 domain of this receptor with nanomolar affinities that decreased in the following order in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay: this receptor > RSPO2 > RSPO3 > RSPO1.... | Leucine-rich repeat-containing G-protein coupled receptor 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00647","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RSPO4 interacts with multiple proteins. One interaction is supported by evidence stating: 'The RSPOs bound the LRR1-14 domain of this receptor with n... | |
medium_divergent_branch_00648 | HIF1A is associated with multiple biological processes. One specific association is supported by evidence that disrupting the V-ATPase causes intracellular iron depletion, which impairs PHD activity and leads to HIF activation. Identify the broader biological category (parent term) of this specific process. | response to metal ion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00648","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIF1A is associated with multiple biological processes. One specific association is supported by evidence that disrupting the V-ATPase causes intrace... | |
medium_divergent_branch_00650 | TRIOBP interacts with multiple proteins. One of these interaction partners is reported to directly bind Tara in vitro and form a complex with Tara in vivo. Which protein, encoded by the gene corresponding to this specific interaction partner, is the target of the query? | E3 ubiquitin-protein ligase HECTD3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00650","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIOBP interacts with multiple proteins. One of these interaction partners is reported to directly bind Tara in vitro and form a complex with Tara in... | |
medium_divergent_branch_00651 | MAPK7 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that both proteins interact directly with each other in vitro and in intact cells, resulting in mutual modulation of their enzymatic activities.' Which protein product is encoded by the gene that interacts with MAPK7 acc... | Receptor-type tyrosine-protein phosphatase R | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00651","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK7 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that both proteins interact directly with each ot... | |
medium_divergent_branch_00652 | hsa-miR-34a-5p regulates more than one cell type. Evidence for one of these regulatory connections indicates that ectopic miR-34a expression suppresses DGKζ protein expression by binding to the 3' untranslated region and coding region of DGKζ mRNA. This suppression leads to increased ERK1/2 phosphorylation and surface ... | lymphocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00652","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-34a-5p regulates more than one cell type. Evidence for one of these regulatory connections indicates that ectopic miR-34a expression suppress... | |
medium_divergent_branch_00653 | SCAP interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation experiments show that SCAP and SREBP-2 form a complex that can be precipitated with antibodies to either component.' Which protein is encoded by the gene corresponding to this interacting partner? | Sterol regulatory element-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00653","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SCAP interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation experiments show that SCAP ... | |
medium_divergent_branch_00654 | CD40LG is involved in multiple biological processes. One of these processes is supported by evidence stating that CD40L costimulation is of fundamental importance in the regulation of IL-4 production. Which biological process is positively regulated by this specific process? | interleukin-4 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00654","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD40LG is involved in multiple biological processes. One of these processes is supported by evidence stating that CD40L costimulation is of fundament... | |
medium_divergent_branch_00655 | The biological process 'negative regulation of sperm capacitation' is defined as any process that stops, prevents, or reduces the frequency, rate, or extent of sperm capacitation. This process is a subtype of a broader regulatory category. Which biological process is negatively regulated by this broader category? | cell maturation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00655","source_qa_id":"medium_divergent_branch_02395","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'negative regulation of sperm capacitation' is defined as any process that... | |
medium_divergent_branch_00656 | PRKAA2 interacts with multiple protein partners. One specific interaction is supported by evidence stating: 'Here, we use coimmunoprecipitation of proteins in transiently transfected cells to show that the alpha2-subunit binds directly not only to the beta-subunit, confirming previous work, but also to the gamma1-subun... | nucleotide-activated protein kinase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00656","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKAA2 interacts with multiple protein partners. One specific interaction is supported by evidence stating: 'Here, we use coimmunoprecipitation of pr... | |
medium_divergent_branch_00657 | PACSIN2 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'When overexpressed, CD95L co-precipitates with FBP17 and PACSIN.' Identify the disease associated with this specific interacting gene via a biomarker relationship. | cholangitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00657","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PACSIN2 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'When overexpressed, CD95L co-precipitates... | |
medium_divergent_branch_00658 | DDR1 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Here, we show that the mammalian DDR receptors bind and are activated by specific types of collagen.' What is the parent molecular function (via an 'is_a' relationship) of the function described by this eviden... | protein-containing complex binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00658","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDR1 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Here, we show that the mammalian DDR r... | |
medium_divergent_branch_00659 | MAGEA3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'In this study, we report that MAGEA3 interacts with this partner and regulates the expression of tyrosine phosphorylated this partner (pY-this partner) in tumor cells.' Which disease is connected to the gene identified by ... | esophageal candidiasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00659","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAGEA3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'In this study, we report that MAGEA3 interacts with... | |
medium_divergent_branch_00660 | The gene ARC interacts with multiple proteins. One of these interacting partners is known to associate with ARC, localize to clathrin-coated pits, and be present at endocytic sites in dendrites and spines. Which protein, encoded by the gene that interacts with ARC in this specific manner, is the subject of this descrip... | E3 ubiquitin-protein ligase RNF216 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00660","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ARC interacts with multiple proteins. One of these interacting partners is known to associate with ARC, localize to clathrin-coated pits, an... | |
medium_divergent_branch_00661 | OTUD3 interacts with multiple proteins. One of these interaction partners is described as forming a complex with OTUD3 and NRF2, thereby stabilizing the downstream NRF2 signaling pathway to facilitate insensitivity to ferroptosis and chemotherapy. Which protein corresponds to this description? | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00661","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OTUD3 interacts with multiple proteins. One of these interaction partners is described as forming a complex with OTUD3 and NRF2, thereby stabilizing ... | |
medium_divergent_branch_00662 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.056 and an adjusted p-value of 0.00463. Which protein does that selected gene encode? | UBA-like domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00662","source_qa_id":"medium_divergent_branch_03736","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_00663 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.282 and an adjusted p-value of 0.0454. Which disease has a genomic-alteration link with that selected gene? | glioblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00663","source_qa_id":"medium_divergent_branch_02732","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_00664 | MAP1S is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'The light chain binds, bundles, and stabilizes microtubules and binds to actin.' Identify the parent molecular function (connected via 'is_a') of the specific function descri... | tubulin binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00664","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP1S is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'The... | |
medium_divergent_branch_00666 | CRBN interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we report that CRBN directly interacts with the α1 subunit of AMP-activated protein kinase (AMPK α1) and inhibits the activation of AMPK activation.' Which disease is connected to this specific interacting gene through... | hypoglycemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00666","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRBN interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we report that CRBN directly interacts with the... | |
medium_divergent_branch_00667 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.195 and an adjusted p-value of 0.0493. Which protein does that selected gene encode? | Solute carrier family 2, facilitated glucose transporter member 12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00667","source_qa_id":"medium_divergent_branch_04999","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_00668 | The pigment granule membrane is a type of cellular component. One definition states it is 'Any membrane that is part of a pigment granule.' Based on this definition, which broader cellular component category does the pigment granule membrane belong to via an 'is a' relationship? | vesicle membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00668","source_qa_id":"medium_divergent_branch_00823","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The pigment granule membrane is a type of cellular component. One definition states it is 'Any me... | |
medium_divergent_branch_00669 | EGFR is involved in multiple biological processes. One such process is supported by evidence stating: 'This translocation was dependent on both activation of EGFR and PKC signaling.' Which biological process is positively regulated by this specific EGFR-associated process? | protein localization to plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00669","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EGFR is involved in multiple biological processes. One such process is supported by evidence stating: 'This translocation was dependent on both activ... | |
medium_divergent_branch_00670 | LHX3 is associated with multiple biological processes. One association is supported by evidence that LHX3 is expressed in defined regions of the sensory epithelium of the developing inner ear, with an expression pattern overlapping that of SOX2. This SOX2 expression precedes LHX3 expression and is known to be required ... | ear development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00670","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LHX3 is associated with multiple biological processes. One association is supported by evidence that LHX3 is expressed in defined regions of the sens... | |
medium_divergent_branch_00671 | DSG1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In similar overlay assays, PP1 binds to DP and Dsc1a, and to a lesser extent, desmoglein 1 (Dsg1), while PG binds to Dsg1 and more weakly to Dsc1a and DP.' Which protein, connected to DSG1 via this binding interaction, is the subj... | Plakophilin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00671","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DSG1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In similar overlay assays, PP1 binds to DP and Dsc1a, and t... | |
medium_divergent_branch_00673 | An axon is structurally associated with multiple anatomical entities via a 'part of' relationship. One of these entities is described as a threadlike extension of a nerve cell, consisting of an axon and a myelin sheath (if myelinated) within the nervous system. These structures are found in both the central and periphe... | multi cell part structure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00673","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"An axon is structurally associated with multiple anatomical entities via a 'part of' relationship. One of these entities is described as a threadlike... | |
medium_divergent_branch_00674 | TRPV4 is associated with multiple biological processes. One specific association is supported by evidence stating: 'These studies of primary cells from patients show how both mutant and WT TRPV4 channels regulate cartilage and bone development.' Identify the biological process described by this evidence, and then deter... | cartilage development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00674","source_qa_id":"medium_divergent_branch_03335","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"TRPV4 is associated with multiple biological processes. One specific association is supported by ... | |
medium_divergent_branch_00675 | NSMAF interacts with multiple proteins. One interaction is supported by evidence stating: 'By means of the yeast interaction trap system, we have identified the scaffolding protein receptor for activated C-kinase (RACK)1 as an interaction partner of FAN.' Which protein product is encoded by the gene corresponding to th... | Small ribosomal subunit protein RACK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00675","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NSMAF interacts with multiple proteins. One interaction is supported by evidence stating: 'By means of the yeast interaction trap system, we have ide... |
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