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medium_divergent_branch_00676 | UBE2I interacts with multiple genes. One interaction is supported by evidence stating: 'In addition, they bind to Ubc9, suggesting that they recruit the E2 enzyme to their respective substrate.' Which gene, linked to UBE2I by this specific interaction, is also known to bind to another partner? | STAT4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00676","source_qa_id":"medium_divergent_branch_06808","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"UBE2I interacts with multiple genes. One interaction is supported by evidence stating: 'In additi... | |
medium_divergent_branch_00677 | Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of approximately -1.092 and an adjusted p-value of 0.03107 in gamma delta T-lymphocytes. Which gene, among those downregulated by Human gammaherpesvirus 4, matches this statistic... | ERBB4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00677","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of appr... | |
medium_divergent_branch_00678 | The gene PRF1 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'In the granules, the interaction partner and perforin are associated as documented by (i) copurification of the interaction partner with perforin but not with granzymes and (ii) immunoprecipitation ... | Calreticulin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00678","source_qa_id":"medium_divergent_branch_00370","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene PRF1 is reported to interact with multiple proteins. One specific interaction is support... | |
medium_divergent_branch_00679 | RUNX2 interacts with multiple proteins. One specific interaction is described by the following evidence: 'Using yeast two-hybrid screening, we demonstrate that Yes-associated protein (YAP) binds to the PY motif of PEBP2alpha through its WW domain.' Identify the gene that encodes the protein mentioned in this evidence (... | Transcriptional coactivator YAP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00679","source_qa_id":"medium_divergent_branch_03338","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RUNX2 interacts with multiple proteins. One specific interaction is described by the following ev... | |
medium_divergent_branch_00681 | The androgen receptor (AR) interacts with multiple proteins. One interaction is characterized by the finding that the AR antagonist RU486 (mifepristone) strongly stimulates the binding between AR and a nuclear receptor corepressor. Which protein, connected to AR through this specific interaction, is encoded by the gene... | Nuclear receptor corepressor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00681","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The androgen receptor (AR) interacts with multiple proteins. One interaction is characterized by the finding that the AR antagonist RU486 (mifepristo... | |
medium_divergent_branch_00682 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.188 and an adjusted p-value of 0.0383. Which protein does that selected gene encode? | ADP-ribosylation factor-like protein 4A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00682","source_qa_id":"medium_divergent_branch_03766","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_00683 | PTEN is implicated in multiple biological processes. One specific association is supported by evidence describing macrocephaly, neuronal hypertrophy, and the presence of hypertrophic and ectopic dendrites and axonal tracts with increased synapses. Which biological process, defined as being a part of the process linked ... | central nervous system neuron development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00683","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTEN is implicated in multiple biological processes. One specific association is supported by evidence describing macrocephaly, neuronal hypertrophy,... | |
medium_divergent_branch_00684 | BIRC5 (survivin) interacts with multiple proteins. One specific interaction partner is described as translocating to the nucleus, where it physically interacts with survivin in response to DNA-damaging agents, both in vitro and in carcinoma tissues from patients who had undergone radiotherapy and/or chemotherapy. Which... | asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00684","source_qa_id":"medium_divergent_branch_06668","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BIRC5 (survivin) interacts with multiple proteins. One specific interaction partner is described ... | |
medium_divergent_branch_00685 | The RB1 gene product interacts with multiple partners. One specific interaction involves a partner whose N-terminus binds Rb, thereby interfering with the partner's interaction with p27 and inhibiting the ubiquitination of p27. Which cellular component is this specific partner located in? | SCF ubiquitin ligase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00685","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The RB1 gene product interacts with multiple partners. One specific interaction involves a partner whose N-terminus binds Rb, thereby interfering wit... | |
medium_divergent_branch_00686 | RAB11FIP2 interacts with multiple proteins. One specific interaction involves a glycolytic kinase that is ubiquitinated by Rab11-FIP2 in NSCLC cells, a process that leads to the inactivation of the oncogenic AKT/mTOR signaling pathway. Which protein is encoded by the gene corresponding to this glycolytic kinase? | Phosphoglycerate kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00686","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB11FIP2 interacts with multiple proteins. One specific interaction involves a glycolytic kinase that is ubiquitinated by Rab11-FIP2 in NSCLC cells,... | |
medium_divergent_branch_00687 | HLA-E is associated with multiple biological processes. One association is supported by evidence showing that CD8(+) T-cells exhibited cytotoxicity against target cells transfected with HLA-E only in the presence of a specific peptide. Which biological process is positively regulated by the process linked to this evide... | T cell mediated cytotoxicity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00687","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HLA-E is associated with multiple biological processes. One association is supported by evidence showing that CD8(+) T-cells exhibited cytotoxicity a... | |
medium_divergent_branch_00688 | BCL2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'A specific peptidyl-prolyl cis-trans isomerase is associated with Bcl-2 and Bcl-x(L) in immunoprecipitation assays and colocalizes with these proteins in mitochondria.' Which protein, linked to BCL2 by this specific inter... | Peptidyl-prolyl cis-trans isomerase FKBP8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00688","source_qa_id":"medium_divergent_branch_02358","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BCL2 interacts with multiple proteins. One specific interaction is supported by evidence stating:... | |
medium_divergent_branch_00689 | PRPS2 interacts with multiple genes. One of these interactions is supported by evidence stating: 'The purified fusion protein had no PRPP synthetase activity, and bound to dissociated PRS I and PRS II, with a similar affinity.' Which protein is encoded by the gene connected to PRPS2 through this specific interaction? | Phosphoribosyl pyrophosphate synthase-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00689","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRPS2 interacts with multiple genes. One of these interactions is supported by evidence stating: 'The purified fusion protein had no PRPP synthetase ... | |
medium_divergent_branch_00690 | EPHB1 is involved in multiple biological processes. One of these processes is characterized by evidence stating that expression of dominant-negative c-Src significantly reduced EPHB1-dependent ERK1/2 activation and chemotaxis. Which biological process is connected to this specific EPHB1-associated process through the '... | cellular response to chemical stimulus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00690","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPHB1 is involved in multiple biological processes. One of these processes is characterized by evidence stating that expression of dominant-negative ... | |
medium_divergent_branch_00691 | VAMP8 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In vitro binding assays show that endobrevin interacts with immobilized recombinant alpha-SNAP fused to glutathione S-transferase (GST).' Identify the disease associated with the gene described by this evidence. | cocaine dependence | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00691","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VAMP8 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In vitro binding assays show that endobrevin intera... | |
medium_divergent_branch_00692 | A kidney proximal straight tubule epithelial cell is a type of which broader cell class, given that it is defined as an epithelial cell of the proximal tubule that is part of some proximal straight tubule? | kidney medulla cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00692","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"A kidney proximal straight tubule epithelial cell is a type of which broader cell class, given that it is defined as an epithelial cell of the proxim... | |
medium_divergent_branch_00693 | The gene STRAP encodes a WD domain-containing protein that interacts with TGF-beta receptors. A specific study identified this protein interacting with TbetaR-I in a yeast two-hybrid system. Based on this evidence, what is the protein product encoded by the gene corresponding to TbetaR-I? | TGF-beta receptor type-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00693","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene STRAP encodes a WD domain-containing protein that interacts with TGF-beta receptors. A specific study identified this protein interacting wi... | |
medium_divergent_branch_00694 | CCR5 interacts with multiple proteins. One interaction is supported by evidence stating: 'The present data suggest that Pro-2, Asp-6, Pro-8, and Thr-9 are critical for the binding of a specific chemokine ligand to the receptor and HIV-1 replication inhibition, and that this ligand's binding to the receptor, regardless ... | C-C motif chemokine 3-like 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00694","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCR5 interacts with multiple proteins. One interaction is supported by evidence stating: 'The present data suggest that Pro-2, Asp-6, Pro-8, and Thr-... | |
medium_divergent_branch_00695 | PRKN interacts with multiple proteins. One interaction is characterized by the mechanism where Parkin prevents the formation of a complex involving RIPK1 and the interacting partner by promoting the polyubiquitination of that partner. Which disease is associated with the interacting partner through genomic alterations? | heart failure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00695","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKN interacts with multiple proteins. One interaction is characterized by the mechanism where Parkin prevents the formation of a complex involving R... | |
medium_divergent_branch_00696 | PDGFA is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'All radiolabeled PDGF isoforms specifically interacted with type I, II, III, IV, V, and VI collagens.' Identify the molecular function linked to this specific association thr... | protein-containing complex binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00696","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDGFA is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'All... | |
medium_divergent_branch_00697 | RASA1 interacts with multiple proteins. One interaction partner is characterized by the following evidence: 'The principal phosphorylation sites on this protein are residues 204 and 221 at the carboxy terminus, and upon phosphorylation tyrosine 221 interacts with the Ras inhibitor p120 RasGAP.' Which cellular component... | cytoplasmic side of plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00697","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RASA1 interacts with multiple proteins. One interaction partner is characterized by the following evidence: 'The principal phosphorylation sites on t... | |
medium_divergent_branch_00698 | GIGYF2 interacts with multiple genes. One of these interaction partners is characterized by evidence showing that it directly interacts with a specific translation initiation factor (also known by its alias m4EHP), an interaction required for the stabilization of both proteins. Which protein is encoded by the gene conn... | Eukaryotic translation initiation factor 4E type 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00698","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GIGYF2 interacts with multiple genes. One of these interaction partners is characterized by evidence showing that it directly interacts with a specif... | |
medium_divergent_branch_00699 | ASF1B interacts with multiple genes. One interaction is supported by evidence stating: 'Furthermore, we demonstrate that hAsf1 proteins can interact directly with the p60 subunit of hCAF-1.' Which biological process is the gene identified by this evidence involved in? | DNA replication-dependent chromatin assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00699","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ASF1B interacts with multiple genes. One interaction is supported by evidence stating: 'Furthermore, we demonstrate that hAsf1 proteins can interact ... | |
medium_divergent_branch_00701 | GNB5 interacts with multiple proteins. One interaction partner is supported by evidence showing that a specific G gamma subunit associates with all five G beta subunits (G beta(1-5)) upon co-translation in vitro and functions with them in modulating Kir3.1/3.4 (GIRK1/4) potassium and N-type (alpha(1B)) calcium channels... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00701","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNB5 interacts with multiple proteins. One interaction partner is supported by evidence showing that a specific G gamma subunit associates with all f... | |
medium_divergent_branch_00702 | PINK1 interacts with multiple proteins. One specific interaction involves a member of the BAG family that directly binds to and stabilizes PINK1 by decreasing its ubiquitination. Which disease is associated with this specific interacting protein as a biomarker? | Alzheimer disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00702","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PINK1 interacts with multiple proteins. One specific interaction involves a member of the BAG family that directly binds to and stabilizes PINK1 by d... | |
medium_divergent_branch_00703 | SUV39H1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report here that the histone methyltransferase SUV39H1, a mammalian ortholog of the Drosophila melanogaster SU(VAR) 3-9, forms complex with a transcription factor.' Which protein, connected to SUV39H1 via an interaction, is ... | Runt-related transcription factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00703","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUV39H1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report here that the histone methyltransferase SUV39H... | |
medium_divergent_branch_00704 | TBX3 is associated with multiple biological processes. One association is supported by evidence that TBX3 cooperates with oncogenes to suppress the induction of p19ARF and p53 (typically caused by Myc and Ras overexpression) and protects against Myc-induced apoptosis. Which biological process, connected to this specifi... | apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00704","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBX3 is associated with multiple biological processes. One association is supported by evidence that TBX3 cooperates with oncogenes to suppress the i... | |
medium_divergent_branch_00706 | The gene IL1RN interacts with multiple receptor genes. One specific interaction is supported by structural evidence describing the crystal structure at 2.7 A resolution of the soluble extracellular part of a type-I interleukin-1 receptor complexed with an interleukin-1 receptor antagonist. Which protein is encoded by t... | Interleukin-1 receptor type 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00706","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL1RN interacts with multiple receptor genes. One specific interaction is supported by structural evidence describing the crystal structure ... | |
medium_divergent_branch_00708 | The gene PDCD1 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by the evidence that Programmed cell death-1 (PD-1) inhibits T cell responses. Which biological process is negatively regulated by the process linked to PDCD1 through this specific e... | T cell activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00708","source_qa_id":"medium_divergent_branch_01739","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene PDCD1 is associated with multiple biological processes via the 'involved in' relationshi... | |
medium_divergent_branch_00709 | BAK1 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We show that the interacting protein interacts with BAK in E6-expressing cells that have been damaged by UV, and provide evidence that the interaction of the interacting protein with BAK requires access to a hy... | Probable E3 ubiquitin-protein ligase HERC1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00709","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAK1 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We show that the interacting protein in... | |
medium_divergent_branch_00710 | In a study of lung fibroblast cell lines (GSE120891), Human mastadenovirus C was found to downregulate a specific gene with a log2 fold change of -1.223 and an adjusted p-value of 0.03813. Which protein is encoded by this downregulated gene? | Protein tyrosine phosphatase type IVA 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00710","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In a study of lung fibroblast cell lines (GSE120891), Human mastadenovirus C was found to downregulate a specific gene with a log2 fold change of -1.... | |
medium_divergent_branch_00713 | C11orf30 interacts with multiple proteins. One interaction is supported by evidence stating: 'Recent work from others and us revealed interactions between the Sin3/HDAC complex, the H3K4me3 demethylase [protein], GATAD1, and EMSY.' Which protein, connected to C11orf30 via an interaction, is described in this evidence a... | Lysine-specific demethylase 5A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00713","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"C11orf30 interacts with multiple proteins. One interaction is supported by evidence stating: 'Recent work from others and us revealed interactions be... | |
medium_divergent_branch_00714 | USP25 interacts with multiple proteins. One specific interaction is described by the following evidence: 'We show here that the deubiquitinase USP25 directly binds to the target protein and prevents the target protein's own ubiquitination and degradation.' Which protein corresponds to this description? | Kelch-like ECH-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00714","source_qa_id":"medium_divergent_branch_01405","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"USP25 interacts with multiple proteins. One specific interaction is described by the following ev... | |
medium_divergent_branch_00715 | The gene DCC interacts with multiple partners via binding. One specific interaction is described by the evidence: 'We find that sNetrin binds exclusively to the fifth fibronectin type III repeat of DCC and to each immunoglobulin repeat of UNC5.' Based on this description, which cellular component is the binding partner... | extracellular region | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00715","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DCC interacts with multiple partners via binding. One specific interaction is described by the evidence: 'We find that sNetrin binds exclusi... | |
medium_divergent_branch_00716 | The CSF1R gene is linked via a binding interaction to multiple other genes. One specific connection is supported by evidence stating: 'Concomitant with their activation, all three Src family kinases were found to associate with the ligand-activated CSF-1 receptor.' Which protein is encoded by the gene that binds to CSF... | Tyrosine-protein kinase Fyn | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00716","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The CSF1R gene is linked via a binding interaction to multiple other genes. One specific connection is supported by evidence stating: 'Concomitant wi... | |
medium_divergent_branch_00717 | HSF2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we show that HSF2 interacts with the polycomb protein [interaction partner].' Which disease is associated with this interaction partner via a biomarker relationship? | gastric carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00717","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSF2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we show that HSF2 interacts with the polycomb pr... | |
medium_divergent_branch_00718 | PEX10 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using two-hybrid studies, blot overlay assays, and coimmunoprecipitation experiments, we observed that the zinc-binding domain of this protein binds both PEX5, the PTS1 receptor, and PEX10, another integral peroxisomal membrane p... | Peroxisome assembly protein 12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00718","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PEX10 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using two-hybrid studies, blot overlay assays, and coimmun... | |
medium_divergent_branch_00719 | DDX6 interacts with multiple proteins. One interaction is supported by evidence stating: 'The C-terminal RecA-like domain of Rck interacts with the N-terminal acidic domain of the protein encoded by the gene corresponding to this specific interaction partner.' Which protein is encoded by the gene corresponding to this ... | Protein PAT1 homolog 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00719","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX6 interacts with multiple proteins. One interaction is supported by evidence stating: 'The C-terminal RecA-like domain of Rck interacts with the N... | |
medium_divergent_branch_00720 | TRPC4AP interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation experiments showed that TRUSS was constitutively associated with unligated TNF-R1 and that the complex was relatively insensitive to stimulation with TNF-alpha.' Which protein, connected to TRPC4AP via th... | Tumor necrosis factor receptor superfamily member 1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00720","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRPC4AP interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation experiments showed that TRUSS was... | |
medium_divergent_branch_00721 | ATF6 interacts with multiple proteins. Experimental evidence, specifically GST pull-down and immunoprecipitation assays, demonstrates that the N-terminal domain of ATF6 binds to the N-terminal domain of a specific binding partner. Which protein, among those interacting with ATF6, is encoded by the gene associated with ... | Sterol regulatory element-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00721","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATF6 interacts with multiple proteins. Experimental evidence, specifically GST pull-down and immunoprecipitation assays, demonstrates that the N-term... | |
medium_divergent_branch_00722 | CASK is involved in multiple biological processes. One of these processes is supported by evidence that RNA interference-mediated knockdown of CASK leads to increased proliferation in cultured keratinocytes and in organotypic skin raft cultures. Which biological process is negatively regulated by this specific CASK-ass... | keratinocyte proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00722","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CASK is involved in multiple biological processes. One of these processes is supported by evidence that RNA interference-mediated knockdown of CASK l... | |
medium_divergent_branch_00723 | SOX15 is associated with multiple biological processes. One association is supported by evidence stating: 'The preferential expression of SOX15 in the myogenic precursor cells led us to suggest that SOX15 is involved in the specification of myogenic cell lineages or in the regulation of the fusion of myoblasts to form ... | myoblast | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00723","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX15 is associated with multiple biological processes. One association is supported by evidence stating: 'The preferential expression of SOX15 in th... | |
medium_divergent_branch_00724 | ANAPC7 interacts with multiple proteins. One specific interaction is described by the evidence: 'In vitro, the C termini of CDC20 and a specific anaphase-promoting complex co-activator bind to the closely related TPR subunits APC3 and APC7.' Which protein corresponds to the entity that binds to APC7 in this statement, ... | Fizzy-related protein homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00724","source_qa_id":"medium_divergent_branch_02172","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ANAPC7 interacts with multiple proteins. One specific interaction is described by the evidence: '... | |
medium_divergent_branch_00725 | CHAF1A interacts with multiple genes. One interaction is supported by evidence stating: 'We now show that this regulation might be more complex; MutSα and CAF-1 interact not only with PCNA, but also with each other.' Which disease is connected to the gene identified by this clue through a biomarker relationship? | lung adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00725","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHAF1A interacts with multiple genes. One interaction is supported by evidence stating: 'We now show that this regulation might be more complex; MutS... | |
medium_divergent_branch_00726 | CDK11B is associated with multiple biological processes. One association is supported by evidence that CDK11(p58) down-regulates Bcl-2 in the pro-apoptosis pathway, a mechanism dependent on its kinase activity. Which broader biological category, defined by an 'is a' relationship, encompasses the specific process linked... | regulation of programmed cell death | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00726","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK11B is associated with multiple biological processes. One association is supported by evidence that CDK11(p58) down-regulates Bcl-2 in the pro-apo... | |
medium_divergent_branch_00727 | ANKZF1 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'A key step of RQC is the cleavage of P-site tRNA by the endonuclease ANKZF1 (Vms1 in yeast) to release incompletely synthesized polypeptides from ribosomes for degradation.' Which broader molecular function ... | catalytic activity, acting on RNA | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00727","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANKZF1 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'A key step of RQC is the cleavage of... | |
medium_divergent_branch_00728 | USP39 interacts with multiple genes. One of these interactions was specifically investigated using co-immunoprecipitation (co-IP) and in vitro deubiquitination analysis. Which disease is connected to this specific interacting gene through genomic alterations? | Bruton-type agammaglobulinemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00728","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP39 interacts with multiple genes. One of these interactions was specifically investigated using co-immunoprecipitation (co-IP) and in vitro deubiq... | |
medium_divergent_branch_00729 | LIG3 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Here, we report that this protein interacts with human polynucleotide kinase in addition to its established interactions with DNA polymerase-beta and DNA ligase III.' Which disease is associated with this specific... | idiopathic pulmonary fibrosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00729","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LIG3 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Here, we report that this protein interact... | |
medium_divergent_branch_00730 | The gene POLK is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We found that Polkappa interacts with a C-terminal region of hREV1.' Based on this clue, which protein does POLK bind to, and what is the name of the protein product encoded by that gene? | Translesion synthesis protein REV1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00730","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene POLK is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We found that Polkappa interac... | |
medium_divergent_branch_00732 | Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of approximately -1.444 and an adjusted p-value of 0.02096 in gamma delta T-lymphocytes. Which disease is associated with the gene that exhibits this specific expression profile? | severe intellectual disability-corpus callosum agenesis-facial dysmorphism-cerebellar ataxia syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00732","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of appr... | |
medium_divergent_branch_00734 | MEF2B interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that mutation of MEF2B resulted in enhanced transcriptional activity of MEF2B, either through disruption of its interaction with the corepressor [this partner] or by rendering MEF2B insensitive to inhibitory s... | Calcineurin-binding protein cabin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00734","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEF2B interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that mutation of MEF2B resulted in enh... | |
medium_divergent_branch_00735 | ACSL3 is associated with multiple biological processes. One association is supported by evidence that overexpression of ACSL3 accelerates, while knockdown blocks, the Golgi export of Lyn. Which biological process is positively regulated by the specific process linked to this evidence? | Golgi to plasma membrane protein transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00735","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACSL3 is associated with multiple biological processes. One association is supported by evidence that overexpression of ACSL3 accelerates, while knoc... | |
medium_divergent_branch_00737 | COMMD7 interacts with multiple proteins. One of these interaction partners cooperates with COMMD7 to down-regulate NF-κB activity. Which protein is encoded by the gene corresponding to this specific interaction partner? | COMM domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00737","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COMMD7 interacts with multiple proteins. One of these interaction partners cooperates with COMMD7 to down-regulate NF-κB activity. Which protein is e... | |
medium_divergent_branch_00738 | The gene CDKN1B interacts with multiple proteins. One interaction is supported by mechanistic studies showing that a specific E3 ubiquitin-protein ligase directly binds to p27 (the protein encoded by CDKN1B) via a VP motif and acts as an E3 ligase to promote p27's ubiquitin-mediated degradation. Which protein is encode... | E3 ubiquitin-protein ligase COP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00738","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CDKN1B interacts with multiple proteins. One interaction is supported by mechanistic studies showing that a specific E3 ubiquitin-protein li... | |
medium_divergent_branch_00739 | TBC1D25 interacts with multiple genes. One interaction is supported by a yeast two-hybrid screen of 2400 combinations of GTP-fixed Rabs and TBC proteins, which found that specific TBC proteins interact with specific Rabs (for example, OATL1 interacts with the target protein, while FLJ12085 interacts with Rab5A/B/C and ... | Ras-related protein Rab-2A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00739","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBC1D25 interacts with multiple genes. One interaction is supported by a yeast two-hybrid screen of 2400 combinations of GTP-fixed Rabs and TBC prote... | |
medium_divergent_branch_00740 | ARL8B is associated with multiple biological processes. One association is supported by evidence stating: 'Overexpression and knockdown of RNF167 revealed its regulatory role in Arl8B-dependent lysosome positioning and endocytic trafficking to lysosomes.' Which biological process, connected to the process implicated by... | vacuolar localization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00740","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARL8B is associated with multiple biological processes. One association is supported by evidence stating: 'Overexpression and knockdown of RNF167 rev... | |
medium_divergent_branch_00741 | CDK4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our previous studies showed that while both specific CDK4 inhibitor p16INK4A (P16) and gankyrin bind to cyclin-dependent kinase 4 (CDK4) in similar fashion, only P16 inhibits the kinase activity of CDK4.' Which disease is associat... | carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00741","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our previous studies showed that while both specific CDK4 i... | |
medium_divergent_branch_00742 | DRD2 interacts with multiple genes. One of these interactions is characterized by agonist-induced heterodimerization, which leads to increased affinity for dopamine, augmented hD2R signaling, and prolonged internalization of the interacting partner. Which disease is associated with this specific interacting gene throug... | arteriosclerosis disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00742","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DRD2 interacts with multiple genes. One of these interactions is characterized by agonist-induced heterodimerization, which leads to increased affini... | |
medium_divergent_branch_00744 | ADAMTS12 is associated with multiple biological processes. One association is supported by evidence stating: 'We also show that addition of recombinant human ADAMTS12 to bovine aortic endothelial cells (BAE-1 cells) abolishes their ability to form tubules upon stimulation with vascular endothelial growth factor (VEGF).... | endothelial tube morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00744","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAMTS12 is associated with multiple biological processes. One association is supported by evidence stating: 'We also show that addition of recombina... | |
medium_divergent_branch_00745 | CDK16 interacts with multiple gene products. One interaction is supported by evidence stating: 'Using the yeast two-hybrid system we screened a mouse brain cDNA library with PCTAIRE-1 as bait, and isolated several clones coding for the mouse homologs of the following proteins: p11 (also known as calpactin I light chain... | 14-3-3 protein eta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00745","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK16 interacts with multiple gene products. One interaction is supported by evidence stating: 'Using the yeast two-hybrid system we screened a mouse... | |
medium_divergent_branch_00746 | LATS2 interacts with multiple proteins. One specific interaction partner is identified by evidence stating: 'Further biochemical characterization of hMOBs showed that only hMOB1A and hMOB1B interact with both LATS1 and LATS2 in vitro and in vivo.' Which disease is associated with this specific interaction partner as a ... | obesity disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00746","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LATS2 interacts with multiple proteins. One specific interaction partner is identified by evidence stating: 'Further biochemical characterization of ... | |
medium_divergent_branch_00747 | CAV1 interacts with multiple proteins. One interaction partner is described by evidence stating that a protein encoded by a gene interacting with CAV1 in the Golgi complex, though this interaction is insufficient for export from that compartment. Which protein is encoded by the gene corresponding to this specific inter... | Caveolin-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00747","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CAV1 interacts with multiple proteins. One interaction partner is described by evidence stating that a protein encoded by a gene interacting with CAV... | |
medium_divergent_branch_00748 | FGF10 is implicated in multiple biological processes. One line of evidence notes that FGF-10 positive cells appeared in all metanephric structures already in the 5th week of development, with intensity increasing as development progressed, suggesting an association with cell survival and nephrogenesis in the permanent ... | kidney development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00748","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF10 is implicated in multiple biological processes. One line of evidence notes that FGF-10 positive cells appeared in all metanephric structures al... | |
medium_divergent_branch_00749 | ARHGEF18 interacts with multiple genes. One specific interaction involves a partner that p114-Rho-GEF binds to specifically in its nucleotide-free and guanosine 5'-[gamma-thio]triphosphate-bound states, while not interacting with Rac1 or Cdc42, and for which p114-Rho-GEF efficiently catalyzes guanine nucleotide exchang... | alopecia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00749","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARHGEF18 interacts with multiple genes. One specific interaction involves a partner that p114-Rho-GEF binds to specifically in its nucleotide-free an... | |
medium_divergent_branch_00750 | ATG16L1 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'We established that ATG16L1 binds to the kinase domain of a specific protein kinase and negatively regulates TLR2-mediated nuclear factor-kappa B (NF-κB) activation and pro-inflammatory cytokine responses b... | allergic asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00750","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATG16L1 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'We established that ATG16L1 binds t... | |
medium_divergent_branch_00751 | FOXA1 interacts with multiple proteins. One of these interaction partners is reported to bind FOXA1 and trigger its ubiquitination and degradation. Which protein, encoded by the gene connected to FOXA1 via this specific interaction, is the subject of this evidence? | E3 ubiquitin-protein ligase NEDD4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00751","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXA1 interacts with multiple proteins. One of these interaction partners is reported to bind FOXA1 and trigger its ubiquitination and degradation. W... | |
medium_divergent_branch_00752 | NDEL1 interacts with multiple genes. One of these interacting partners is described in literature as 'NUDEL, a novel protein-interacting protein with sequence homology to gene products also implicated in nuclear distribution in fungi.' Which disease is associated with this specific interacting gene through genomic alte... | Miller-Dieker lissencephaly syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00752","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NDEL1 interacts with multiple genes. One of these interacting partners is described in literature as 'NUDEL, a novel protein-interacting protein with... | |
medium_divergent_branch_00753 | Human gammaherpesvirus 4 is known to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of approximately -1.51 and an adjusted p-value of approximately 0.031. Which disease is associated with the gene subject to this specific downregulation via a biomarker relationship... | polycystic ovary syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00753","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human gammaherpesvirus 4 is known to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of approxi... | |
medium_divergent_branch_00754 | ITGA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Then we identified integrin alpha1 as a [protein encoded by the interacting gene]-interacting protein for the first time, and verified this physical association with pull-down and co-immunoprecipitation assays.' Which protein is ... | Protein tyrosine phosphatase type IVA 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00754","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Then we identified integrin alpha1 as a [protein encoded b... | |
medium_divergent_branch_00755 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.418 and an adjusted p-value of 0.0493. Which protein does that selected gene encode? | Zinc finger protein 521 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00755","source_qa_id":"medium_divergent_branch_02619","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_00756 | The gene SLC29A4 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'The plasma membrane monoamine transporter (PMAT) and organic cation transporter 3 (OCT3) are the two most prominent low-affinity, high-capacity (i.e., uptake(2)) transporters for endogenous biogeni... | monoamine transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00756","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SLC29A4 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'The plasma membrane monoam... | |
medium_divergent_branch_00757 | The biological process 'positive regulation of T-helper 1 type immune response' is enabled by multiple cell types. One such cell is described as a mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses. Which cell type does this specific NK T cell develop from? | activated CD4-negative, CD8-negative type I NK T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00757","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process 'positive regulation of T-helper 1 type immune response' is enabled by multiple cell types. One such cell is described as a ma... | |
medium_divergent_branch_00758 | The gene CHM is known to interact with multiple proteins. One specific interaction is supported by experimental evidence stating: 'Finally, gel filtration analysis of cytosolic fractions from 293 cells that were coexpressing T7 epitope-tagged REP with various Myc-tagged constructs revealed that mutations in the alpha2 ... | Ras-related protein Rab-1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00758","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CHM is known to interact with multiple proteins. One specific interaction is supported by experimental evidence stating: 'Finally, gel filtr... | |
medium_divergent_branch_00759 | CADM1 interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Here, we report that TSLC1 directly associates with this protein, one of the human homologues of a Drosophila tumor suppressor gene, Discs large (Dlg).' Which protein product is encoded by the gene corresp... | MAGUK p55 subfamily member 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00759","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CADM1 interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Here, we report that TSLC1 directl... | |
medium_divergent_branch_00760 | MICU1 interacts with multiple proteins. One specific interaction involves a partner that forms a disulfide-linked heterodimer with MICU1, acting as a gatekeeper for the pore-forming MCU protein. Which protein is this partner? | Calcium uptake protein 2, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00760","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MICU1 interacts with multiple proteins. One specific interaction involves a partner that forms a disulfide-linked heterodimer with MICU1, acting as a... | |
medium_divergent_branch_00761 | The gene IKBKE is known to interact with multiple partners. One specific interaction partner was identified through yeast two-hybrid screening as a molecule that binds specifically to inducible IkappaB kinase (IKK-i), and this partner is referred to as a specific adaptor protein. Which protein is encoded by this specif... | TRAF family member-associated NF-kappa-B activator | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00761","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IKBKE is known to interact with multiple partners. One specific interaction partner was identified through yeast two-hybrid screening as a m... | |
medium_divergent_branch_00762 | MCRS1 interacts with multiple genes. One of these interaction partners is supported by evidence showing that MCRS2 interacts with it in vitro and in vivo, and colocalizes with it in cells. Which disease is associated with this specific interaction partner through genomic alterations? | liver cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00762","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCRS1 interacts with multiple genes. One of these interaction partners is supported by evidence showing that MCRS2 interacts with it in vitro and in ... | |
medium_divergent_branch_00763 | BRCA2 is known to bind to multiple genes. One of these binding partners is characterized by evidence stating that it and BRCA2 proteins co-precipitate in both human and hamster cells, and this interaction requires FANCG. Which gene, connected to BRCA2 through a binding relationship, matches this description and is subs... | TRIM25 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00763","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRCA2 is known to bind to multiple genes. One of these binding partners is characterized by evidence stating that it and BRCA2 proteins co-precipitat... | |
medium_divergent_branch_00764 | SMCR8 interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Here, we found that this protein forms a complex with the WDR41 and SMCR8 proteins to act as a GDP/GTP exchange factor for RAB8a and RAB39b and to thereby control autophagic flux.' What is the name of the ... | Guanine nucleotide exchange factor C9orf72 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00764","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMCR8 interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Here, we found that this protein f... | |
medium_divergent_branch_00765 | RPGR interacts with multiple proteins. One interaction was identified via mass spectrometric analysis of proteins immunoprecipitated from a retinal axoneme-enriched fraction using an anti-ORF15 antibody, which detected two chromosome-associated proteins: structural maintenance of chromosomes (SMC) 1 and another SMC pro... | Structural maintenance of chromosomes protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00765","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPGR interacts with multiple proteins. One interaction was identified via mass spectrometric analysis of proteins immunoprecipitated from a retinal a... | |
medium_divergent_branch_00766 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 3.205 and an adjusted p-value of 0.0126. Which protein does that selected gene encode? | Granulocyte-macrophage colony-stimulating factor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00766","source_qa_id":"medium_divergent_branch_07226","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_00767 | RBBP4 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'We show that RBBP4 binds to the N-terminal amino acid residues of PRDM3 and this partner, with a dissociation constant of 3.0 μM, as measured by isothermal titration calorimetry.' Which disease is associated ... | chromosome 1p36 deletion syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00767","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBBP4 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'We show that RBBP4 binds to the N-ter... | |
medium_divergent_branch_00768 | EIF2AK2 interacts with multiple genes. One of these interactions is supported by evidence describing the colocalization and physical interaction between PKR and TRAF family proteins in vivo, demonstrated through immunoprecipitation and confocal microscopy. Which disease is associated with the gene identified by this sp... | bone resorption disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00768","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF2AK2 interacts with multiple genes. One of these interactions is supported by evidence describing the colocalization and physical interaction betw... | |
medium_divergent_branch_00769 | AMOTL2 interacts with multiple genes. One specific interaction partner was identified and confirmed as a novel binding partner of AMOTL2 in NSCLC cells using mass spectrometry, co-immunoprecipitation, GST pull-down, and immunofluorescence. Which disease is associated with this specific interaction partner? | biliary atresia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00769","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMOTL2 interacts with multiple genes. One specific interaction partner was identified and confirmed as a novel binding partner of AMOTL2 in NSCLC cel... | |
medium_divergent_branch_00770 | FANCE interacts with multiple proteins. One of these interacting partners is described as functioning as a molecular adaptor within the FA nuclear complex, bridging between the subcomplexes A:G and C:E. Which disease is associated with this specific interacting protein via a biomarker relationship? | multiple evanescent white dot syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00770","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCE interacts with multiple proteins. One of these interacting partners is described as functioning as a molecular adaptor within the FA nuclear co... | |
medium_divergent_branch_00771 | The protein LAT interacts with multiple partners. One specific interaction is supported by evidence showing that the partner protein is co-precipitated with LAT in pervanadate-activated Jurkat cells. Which disease is associated with this specific partner protein through genomic alterations? | type 1 diabetes mellitus 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00771","source_qa_id":"medium_divergent_branch_01275","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein LAT interacts with multiple partners. One specific interaction is supported by eviden... | |
medium_divergent_branch_00772 | A neuronal receptor cell is a type of cell that connects to a specific parent class via an 'is a' relationship. Evidence for one of these connections describes the entity as a neuron capable of detecting stimuli involved in sensory perception. Which cell is the parent class connected to the neuronal receptor cell throu... | afferent neuron | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00772","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"A neuronal receptor cell is a type of cell that connects to a specific parent class via an 'is a' relationship. Evidence for one of these connections... | |
medium_divergent_branch_00773 | PARK7 (DJ-1) interacts with multiple genes. One interaction is supported by evidence showing that DJ-1 directly binds to the AR-binding region of a specific PIAS family member in an in vitro coimmunoprecipitation assay and also binds to this gene in human 293T cells. Which disease is connected to this specific interact... | childhood acute lymphoblastic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00773","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARK7 (DJ-1) interacts with multiple genes. One interaction is supported by evidence showing that DJ-1 directly binds to the AR-binding region of a s... | |
medium_divergent_branch_00774 | MTA3 interacts with multiple genes. One of these interaction partners is known to physically interact with the Mi-2/NuRD complex, an interaction that is sensitive to the acetylation status of the partner protein. Which disease is associated with this specific interaction partner through genomic alterations? | gonorrhea | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00774","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTA3 interacts with multiple genes. One of these interaction partners is known to physically interact with the Mi-2/NuRD complex, an interaction that... | |
medium_divergent_branch_00775 | The angular vein is a type of anatomy. One description states: 'The angular vein, formed by the junction of the frontal vein and supraorbital vein, runs obliquely downward on the side of the root of the nose to the level of the lower margin of the orbit, where it becomes the anterior facial vein. It receives the extern... | systemic vein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00775","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The angular vein is a type of anatomy. One description states: 'The angular vein, formed by the junction of the frontal vein and supraorbital vein, r... | |
medium_divergent_branch_00776 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.015 and an adjusted p-value of 0.0422. Which disease is associated with that selected gene? | idiopathic hypersomnia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00776","source_qa_id":"medium_divergent_branch_03639","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_00777 | MEGF10 is associated with multiple biological processes. One association is supported by evidence stating that MEGF10 is highly expressed in activated satellite cells and regulates their proliferation, differentiation, and fusion into multinucleated myofibers. Which biological process, connected to the process supporte... | muscle cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00777","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEGF10 is associated with multiple biological processes. One association is supported by evidence stating that MEGF10 is highly expressed in activate... | |
medium_divergent_branch_00778 | The RB1 gene interacts with multiple partners. One interaction is supported by evidence stating: 'This and the observation that pRB forms a specific complex with p34cdc2 in vivo suggests that p34cdc2 or a p34cdc2-related protein is a major pRB kinase.' Which protein is encoded by the gene that interacts with RB1 in thi... | Cyclin-dependent kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00778","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The RB1 gene interacts with multiple partners. One interaction is supported by evidence stating: 'This and the observation that pRB forms a specific ... | |
medium_divergent_branch_00779 | RNF168 interacts with multiple proteins. One specific interaction is described by the statement: 'Here we report that RNF168, an E3 ligase mutated in the human RIDDLE syndrome, interacts with a topoisomerase II alpha isoform and mediates its ubiquitylation.' Which protein product is encoded by the gene corresponding to... | DNA topoisomerase 2-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00779","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF168 interacts with multiple proteins. One specific interaction is described by the statement: 'Here we report that RNF168, an E3 ligase mutated in... | |
medium_divergent_branch_00780 | EFEMP1 interacts with multiple proteins. Evidence indicates that eight specific interactions involving EFEMP1, including those with ERdj5, PDIA6, and others, were verified at the western blotting level. Which protein among these verified interactors is encoded by the gene connected to EFEMP1 via an interaction? | Protein disulfide-isomerase A4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00780","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EFEMP1 interacts with multiple proteins. Evidence indicates that eight specific interactions involving EFEMP1, including those with ERdj5, PDIA6, and... | |
medium_divergent_branch_00781 | MRPL48 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence showing that Oxa1L-CTT cross-links to mammalian mitochondrial homologs of bacterial ribosomal proteins L13, L20, and L28, as well as to mammalian mitochondrial-specific ribosomal proteins M... | mitochondrial matrix | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00781","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MRPL48 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence showing that Oxa1L... | |
medium_divergent_branch_00782 | PSMB8 is associated with multiple biological processes. One of these processes is supported by evidence stating that downregulation of PSMB8 inhibited the differentiation of murine and human adipocytes in vitro. Which cell type is the final product of this specific biological process? | adipocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00782","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMB8 is associated with multiple biological processes. One of these processes is supported by evidence stating that downregulation of PSMB8 inhibite... | |
medium_divergent_branch_00783 | The gene BCL2L11 (encoding Bim) interacts with multiple partners. One interaction is supported by evidence stating: 'We have shown for the first time that the interaction partner directly binds to the BH3-only proapoptotic protein Bim.' Which cell type is enriched in the gene corresponding to this specific interaction ... | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00783","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BCL2L11 (encoding Bim) interacts with multiple partners. One interaction is supported by evidence stating: 'We have shown for the first time... | |
medium_divergent_branch_00784 | DDX27 interacts with multiple proteins. One interaction is supported by evidence stating: 'Applying a mass spectrometric analysis, we identified the DEAD-box helicase DDX27 as stably associated factor of the PeBoW-complex.' Which protein, connected to DDX27 via this specific interaction, is the subject of the query reg... | Ribosome biogenesis protein WDR12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00784","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX27 interacts with multiple proteins. One interaction is supported by evidence stating: 'Applying a mass spectrometric analysis, we identified the ... | |
medium_divergent_branch_00785 | PRDX3 interacts with multiple proteins. One interaction is supported by evidence stating: 'By means of a yeast two-hybrid screening system, we have identified a molecule localized to mitochondria, antioxidant protein-1 (AOP-1), that binds to a specific kinase and which acts as a modulator of its activity.' Which protei... | Mitogen-activated protein kinase kinase kinase 13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00785","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRDX3 interacts with multiple proteins. One interaction is supported by evidence stating: 'By means of a yeast two-hybrid screening system, we have i... |
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