qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
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medium_divergent_branch_00786 | HIP1 interacts with multiple proteins. One specific interaction involves a polypeptide which exhibits partial sequence homology to Hip-1 and shares similar tissue and subcellular distribution patterns. Which protein, encoded by the gene connected to HIP1 via this specific interaction, is the subject of this description... | Intraflagellar transport protein 57 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00786","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIP1 interacts with multiple proteins. One specific interaction involves a polypeptide which exhibits partial sequence homology to Hip-1 and shares s... | |
medium_divergent_branch_00787 | ATG16L1 interacts with multiple genes. One of these interactions is characterized by the following mechanism: independent of the adaptor RIP2 and the transcription factor NF-kappaB, Nod1 and the interacting partner recruit the autophagy protein ATG16L1 to the plasma membrane at the bacterial entry site. Which disease i... | middle cerebral artery infarction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00787","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATG16L1 interacts with multiple genes. One of these interactions is characterized by the following mechanism: independent of the adaptor RIP2 and the... | |
medium_divergent_branch_00788 | ING1 interacts with multiple proteins. One specific interaction involves the p33(ING1b) splicing isoform of ING1, which binds to members of the 14-3-3 family of proteins, a process regulated by the phosphorylation status of ING1. Which protein, connected to ING1 via this interaction, is encoded by the gene in question? | 14-3-3 protein eta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00788","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ING1 interacts with multiple proteins. One specific interaction involves the p33(ING1b) splicing isoform of ING1, which binds to members of the 14-3-... | |
medium_divergent_branch_00789 | The protein PRLR is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Scatchard analysis of the intermediate PRLr revealed an affinity for PRL comparable with the long PRLr.' Which molecular function, connected to the function suppor... | cytokine receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00789","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein PRLR is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence st... | |
medium_divergent_branch_00790 | PMEPA1 interacts with multiple proteins. One of these interaction partners is described in the context of TMEPAI binding, where it is noted that TMEPAI binds the ubiquitin-binding proteins Hrs and this specific partner, which is required for TMEPAI's lysosomal transport. Which protein is this interaction partner? | Signal transducing adapter molecule 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00790","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PMEPA1 interacts with multiple proteins. One of these interaction partners is described in the context of TMEPAI binding, where it is noted that TMEP... | |
medium_divergent_branch_00792 | PLIN2 interacts with multiple proteins. One interaction partner is characterized by the following mechanism: 'At the molecular level, interactions between this protein and PLIN2 were found to abrogate TEB4-mediated PLIN2 ubiquitination and consequent degradation, thus maintaining higher PLIN2 expression levels.' Which ... | Tribbles homolog 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00792","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLIN2 interacts with multiple proteins. One interaction partner is characterized by the following mechanism: 'At the molecular level, interactions be... | |
medium_divergent_branch_00793 | MAPK1 interacts with multiple genes. One interaction is supported by evidence showing that ERK1 and ERK2 were present in RSK3 (and to a lesser extent, a related kinase) immunoprecipitates, but were absent in RSK1 immunoprecipitates. Which gene, connected to MAPK1 via this specific interaction evidence, also binds to an... | SH3GL2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00793","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK1 interacts with multiple genes. One interaction is supported by evidence showing that ERK1 and ERK2 were present in RSK3 (and to a lesser extent... | |
medium_divergent_branch_00794 | The gene KCNQ1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'In the heart, KCNQ1 alpha-subunits assemble with KCNE1 beta-subunits forming a channel complex constituting the delayed rectifier current I(Ks).' Which biological process, connected to KCNQ1 via ... | regulation of biological quality | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00794","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene KCNQ1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'In the heart, KCNQ1 alph... | |
medium_divergent_branch_00795 | IGF2 interacts with multiple binding partners. One specific interaction is supported by evidence stating: 'We now demonstrate using three independent methods that human IGFBP-5, when occupied by IGF-I or IGF-II, forms ternary complexes of approximately 130 kDa with the acid-labile subunit.' Which disease is associated ... | Crohn disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00795","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGF2 interacts with multiple binding partners. One specific interaction is supported by evidence stating: 'We now demonstrate using three independent... | |
medium_divergent_branch_00796 | The SBDS gene is associated with multiple biological processes. One specific association is supported by evidence stating: 'the differentiation and proliferation capacity of SDS-patient bone marrow hematopoietic progenitor cells in a liquid differentiation system was reduced as compared to control cultures.' Identify t... | hemopoiesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00796","source_qa_id":"medium_divergent_branch_05257","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The SBDS gene is associated with multiple biological processes. One specific association is suppo... | |
medium_divergent_branch_00797 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.328 and an adjusted p-value of 0.00941. Which protein does that selected gene encode? | Coiled-coil domain-containing protein 71L | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00797","source_qa_id":"medium_divergent_branch_01698","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_00798 | The protein CCDC39 is associated with multiple biological processes. One association is supported by evidence stating: 'Functional analyses indicated that CCDC39 localizes to ciliary axonemes and is essential for assembly of inner dynein arms and the dynein regulatory complex.' Which biological process, connected to th... | protein-containing complex assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00798","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CCDC39 is associated with multiple biological processes. One association is supported by evidence stating: 'Functional analyses indicated... | |
medium_divergent_branch_00799 | SUMO2 interacts with multiple genes. One of these interactions is characterized by the finding that serine residues adjacent to the hydrophobic core are phosphorylated by CK2, a modification that dictates the binding of free SUMO and SUMO conjugates to the interacting partner in vivo. Which disease is associated with t... | essential thrombocythemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00799","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUMO2 interacts with multiple genes. One of these interactions is characterized by the finding that serine residues adjacent to the hydrophobic core ... | |
medium_divergent_branch_00800 | HERC2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using an RNA interference-resistant transgene approach in combination with structure-function analyses, we show that the association between a centriolar protein and HERC2 depends on nonoverlapping regions of NEURL4.' Which prote... | Centriolar coiled-coil protein of 110 kDa | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00800","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HERC2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using an RNA interference-resistant transgene approach in ... | |
medium_divergent_branch_00801 | APOE interacts with multiple proteins. One interaction partner is supported by evidence showing that POPC-apoE particles (generated using apoE3, apoE4, truncated apoE4 variants, and the apoE4R158M mutant) bind tightly to a specific receptor. Which protein, encoded by the gene connected to APOE via this specific interac... | Low-density lipoprotein receptor-related protein 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00801","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APOE interacts with multiple proteins. One interaction partner is supported by evidence showing that POPC-apoE particles (generated using apoE3, apoE... | |
medium_divergent_branch_00802 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.380 and an adjusted p-value of 0.0422. Which gene interacts with that selected gene? | RECQL4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00802","source_qa_id":"medium_divergent_branch_03677","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_00803 | Myelin basic protein (MBP) interacts with multiple partners. One specific interaction is supported by evidence stating: 'The interaction of human myelin basic protein with lipophilin has been demonstrated by affinity chromatography.' Identify the gene corresponding to this partner. Then, determine which gene interacts ... | CREB3L1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00803","source_qa_id":"medium_divergent_branch_06414","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Myelin basic protein (MBP) interacts with multiple partners. One specific interaction is supporte... | |
medium_divergent_branch_00805 | The gene ITGA3 is associated with multiple biological processes. One association is supported by evidence stating: 'Although integrins are the most important receptors for ECM proteins and are ubiquitously expressed during kidney development, mice lacking expression of integrin α3 do not demonstrate a reduced number of... | renal system process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00805","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ITGA3 is associated with multiple biological processes. One association is supported by evidence stating: 'Although integrins are the most i... | |
medium_divergent_branch_00806 | PRKACA interacts with multiple proteins. One interaction is supported by evidence describing a macromolecular complex defined via cosedimentation and coimmunoprecipitation, which includes the interacting partner, FKBP12.6, PKA, protein phosphatases PP1 and PP2A, and the anchoring protein mAKAP. Which protein correspond... | Ryanodine receptor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00806","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKACA interacts with multiple proteins. One interaction is supported by evidence describing a macromolecular complex defined via cosedimentation and... | |
medium_divergent_branch_00807 | SWSAP1 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that it interacts with RAD51 and RAD51 paralogs, and that its depletion causes defects in homologous recombination repair. Which protein is connected to the gene SWSAP1 through the 'interacts with' relation, ... | DNA repair protein RAD51 homolog 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00807","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SWSAP1 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that it interacts with RAD51 and RAD5... | |
medium_divergent_branch_00808 | The CSK protein interacts with multiple partners. One specific interaction is supported by evidence stating: 'We show that hnRNP K and the c-Src kinase specifically interact with each other, leading to c-Src activation and tyrosine phosphorylation of hnRNP K in vivo and in vitro.' Which disease is associated with the g... | polyarticular arthritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00808","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The CSK protein interacts with multiple partners. One specific interaction is supported by evidence stating: 'We show that hnRNP K and the c-Src kina... | |
medium_divergent_branch_00809 | PTGFRN is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Cross-linking experiments detected a complex of the size of the interaction partner plus PTGFRN, showing that these glycoproteins directly associate with each other, probably in the absence of any other mo... | CD9 antigen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00809","source_qa_id":"medium_divergent_branch_03615","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PTGFRN is reported to interact with multiple proteins. One specific interaction is supported by e... | |
medium_divergent_branch_00811 | The enzyme CYP4F2 is associated with multiple biological processes. One specific association is supported by evidence that the GA/AA genotype of CYP4F2 is significantly linked to increased 20-hydroxyeicosatetraenoic acid excretion and elevated systolic blood pressure. Which biological process, connected to this specifi... | blood circulation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00811","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The enzyme CYP4F2 is associated with multiple biological processes. One specific association is supported by evidence that the GA/AA genotype of CYP4... | |
medium_divergent_branch_00812 | The gene SCN2A is associated with multiple molecular functions. One specific function is supported by evidence stating that variants in SCN2A disrupt the encoded neuronal sodium channel NaV1.2, which are risk factors for autism spectrum disorder, developmental delay, and infantile seizures. What is the parent molecular... | sodium channel activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00812","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SCN2A is associated with multiple molecular functions. One specific function is supported by evidence stating that variants in SCN2A disrupt... | |
medium_divergent_branch_00813 | CD274 (PD-L1) interacts with multiple genes. One of these interacting partners has been shown to directly interact with PD-L1 and increase its abundance in colorectal and prostate cancer cells. Which gene is this interacting partner? | DCAF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00813","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD274 (PD-L1) interacts with multiple genes. One of these interacting partners has been shown to directly interact with PD-L1 and increase its abunda... | |
medium_divergent_branch_00814 | SPTAN1 interacts with multiple partners. One specific interaction involves the N-terminal region of non-erythroid alpha spectrin (Sp alpha II) binding to beta spectrin to form functional spectrin tetramers. Which disease is associated with the gene encoding this specific binding partner? | autosomal recessive spinocerebellar ataxia 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00814","source_qa_id":"medium_divergent_branch_03952","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SPTAN1 interacts with multiple partners. One specific interaction involves the N-terminal region ... | |
medium_divergent_branch_00815 | The gene AGER interacts with multiple partners. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation studies showed that diabetes increased the interaction between CXCL12 and CXCR4 and between this interaction partner and receptor for advanced glycation end products (RAGE), but not between... | gastric cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00815","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AGER interacts with multiple partners. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation studies showed tha... | |
medium_divergent_branch_00816 | The gene NIBAN2 (FAM129B) interacts with multiple partners. One specific interaction is supported by evidence including immunofluorescence, colocalization, co-immunoprecipitation, and mammalian two-hybrid assays. Which protein is encoded by the gene that interacts with FAM129B in this manner? | Kelch-like ECH-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00816","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NIBAN2 (FAM129B) interacts with multiple partners. One specific interaction is supported by evidence including immunofluorescence, colocaliz... | |
medium_divergent_branch_00817 | The gene CNTROB interacts with multiple proteins. One specific interaction is supported by evidence stating that ectopic spindle pole-associated transient multipolarity and multipolar segregation in cells deficient for the interacting protein are suppressed by removing centrobin, which interacts with and is ubiquitinat... | E3 ubiquitin-protein ligase TRIM37 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00817","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CNTROB interacts with multiple proteins. One specific interaction is supported by evidence stating that ectopic spindle pole-associated tran... | |
medium_divergent_branch_00820 | MAP3K7 interacts with multiple proteins. One interaction partner is described in evidence stating that VRK2, a member of a novel Ser-Thr kinase family, stably interacts with an interaction partner of MAP3K7, TAK1, and MKK7, but not JNK, and can be isolated in oligomeric complexes containing TAK1, MKK7beta1, and JNK. Wh... | C-Jun-amino-terminal kinase-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00820","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K7 interacts with multiple proteins. One interaction partner is described in evidence stating that VRK2, a member of a novel Ser-Thr kinase famil... | |
medium_divergent_branch_00821 | HIST3H3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that direct interaction between the chromodomain of a histone acetyltransferase and histone H3 trimethylated on lysine 9 (H3K9me3) at DSBs activates the acetyltransferase activity of this protein.' Which disease i... | mammary neoplasms, animal | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00821","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIST3H3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that direct interaction between the chromo... | |
medium_divergent_branch_00823 | TNK2 interacts with multiple genes. One of these interaction partners is described in evidence stating that ACK1 binds to it and is essential for the phosphorylation of AKT induced by FGF. Which disease is genetically associated with this specific gene? | hypersensitivity reaction disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00823","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNK2 interacts with multiple genes. One of these interaction partners is described in evidence stating that ACK1 binds to it and is essential for the... | |
medium_divergent_branch_00824 | SOCS4 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 10.22 TPM, a z-score of 1.91, and a fold enrichment of 2.41. Which cell type is the parent class (is_a) of the cell type matching these expression statistics? | group 1 innate lymphoid cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00824","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOCS4 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 10.22 TPM, a z-score of 1.91, and a fold enrichment o... | |
medium_divergent_branch_00825 | FOXK2 interacts with multiple proteins. One specific interaction involves a partner that, in a ternary complex with BAP1, is bridged by BAP1 to a host cell factor. Which protein is encoded by the gene corresponding to this specific interaction partner? | Host cell factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00825","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXK2 interacts with multiple proteins. One specific interaction involves a partner that, in a ternary complex with BAP1, is bridged by BAP1 to a hos... | |
medium_divergent_branch_00826 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.167 and an adjusted p-value of 0.0469. For which disease is that selected gene recorded as a biomarker? | lung carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00826","source_qa_id":"medium_divergent_branch_04426","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_00827 | NCOA3 interacts with multiple genes. One interaction is supported by evidence stating: 'The crystal structure of the glucocorticoid receptor ligand binding domain bound to DAC and the fourth LXXLL motif of steroid receptor coactivator 1 reveals that the glucocorticoid receptor ligand binding pocket is expanded to a siz... | asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00827","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOA3 interacts with multiple genes. One interaction is supported by evidence stating: 'The crystal structure of the glucocorticoid receptor ligand b... | |
medium_divergent_branch_00830 | ELF3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we found that a signaling kinase, p21-activated kinase-1, interacts with and phosphorylates ESE-1.' Which protein is encoded by the gene corresponding to this signaling kinase? | Serine/threonine-protein kinase PAK 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00830","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ELF3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we found that a signaling kinase, p21-activated kinase... | |
medium_divergent_branch_00831 | HMGA2 is associated with multiple biological processes. One association is supported by evidence stating: 'We demonstrate that HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.' Which biological process, connected to HMGA2, is linked via a 'positively regulates' r... | gene expression | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00831","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMGA2 is associated with multiple biological processes. One association is supported by evidence stating: 'We demonstrate that HMGA2 directly binds t... | |
medium_divergent_branch_00832 | MBTD1 interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Here we identified MBTD1 as a stable subunit of the complex, and we reveal that, via a histone reader domain for H4K20me1/2, MBTD1 allows TIP60 to associate with specific gene promoters and to promote the ... | E1A-binding protein p400 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00832","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MBTD1 interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Here we identified MBTD1 as a stab... | |
medium_divergent_branch_00833 | The gene MYO5A is associated with multiple biological processes. One association is supported by evidence stating: 'Here we provide direct evidence that myosin-V is indeed a processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament.' Identify the biological pr... | actin filament-based process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00833","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MYO5A is associated with multiple biological processes. One association is supported by evidence stating: 'Here we provide direct evidence t... | |
medium_divergent_branch_00834 | SIK1 interacts with multiple proteins. One specific interaction is described by the following evidence: 'Through biochemical studies, we found that SIK1 and SIK3 interact with TGF-β-activated kinase 1-binding protein 2, and interrupt the functional complex of this protein with TNF receptor-associated factor 6 (TRAF6).'... | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00834","source_qa_id":"medium_divergent_branch_00141","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SIK1 interacts with multiple proteins. One specific interaction is described by the following evi... | |
medium_divergent_branch_00835 | BCL9 is reported to bind multiple gene products. One specific interaction is supported by evidence stating: 'Furthermore, we demonstrate that BCL9-2 can functionally replace Lgs both in cultured cells as well as in vivo and that this rescue activity depends on the ability of BCL9-2 to bind Pygo.' Which cellular compone... | beta-catenin-TCF complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00835","source_qa_id":"medium_divergent_branch_05124","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BCL9 is reported to bind multiple gene products. One specific interaction is supported by evidenc... | |
medium_divergent_branch_00836 | RAP1A interacts with multiple genes. One of these interacting partners is described in evidence stating: 'Two of these GEFs, MR-GEF (M-Ras-regulated GEF, KIAA0277) and PDZ-GEF (a specific GEF) bound specifically to nucleotide-free Rap1 and Rap1/Rap2, respectively.' Which disease is associated with the gene identified b... | epilepsy, familial adult myoclonic, 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00836","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAP1A interacts with multiple genes. One of these interacting partners is described in evidence stating: 'Two of these GEFs, MR-GEF (M-Ras-regulated ... | |
medium_divergent_branch_00837 | NCOA1 interacts with multiple proteins. One specific interaction is described by the following evidence: 'In electrophoretic mobility shift assays, wild-type [Thyroid hormone receptor beta] interacted with N-CoR in the absence of ligand, whereas T3 caused dissociation of the [Thyroid hormone receptor beta]/N-CoR comple... | Thyroid hormone receptor beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00837","source_qa_id":"medium_divergent_branch_07238","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"NCOA1 interacts with multiple proteins. One specific interaction is described by the following ev... | |
medium_divergent_branch_00838 | ROR1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Analysis of the [protein] interactome using BioID and immunoprecipitation showed that the [protein] can interact with the core receptor complex components dedicated to the noncanonical Wnt pathway such as ROR1, ROR2, VANGL1, and V... | E3 ubiquitin-protein ligase RNF43 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00838","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ROR1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Analysis of the [protein] interactome using BioID and immun... | |
medium_divergent_branch_00839 | HIST4H4 interacts with multiple genes. One of these interacting partners is characterized by experimental evidence showing that it avidly binds to di- and tetraacetylated histone H4 and diacetylated H3 in peptide binding assays, while binding weakly or not at all to mono- and unacetylated H3 and H4. Which disease is as... | Cornelia de Lange syndrome 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00839","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIST4H4 interacts with multiple genes. One of these interacting partners is characterized by experimental evidence showing that it avidly binds to di... | |
medium_divergent_branch_00840 | NCK1 interacts with multiple proteins. One specific interaction involves NCK1 binding to a partner protein via its second SH3 domain at a site corresponding to amino acids 321-415 of the partner, which is distinct from the WASP-binding site (amino acids 416-488). Which cellular component is this specific partner protei... | actin cytoskeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00840","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCK1 interacts with multiple proteins. One specific interaction involves NCK1 binding to a partner protein via its second SH3 domain at a site corres... | |
medium_divergent_branch_00841 | ING4 interacts with multiple genes. One of these interaction partners is described as a HIF prolyl hydroxylase, an Fe(II)-dependent oxygenase that mediates HIF stability in response to oxygen availability. Which disease is genetically associated with this specific interaction partner? | pulmonary edema | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00841","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ING4 interacts with multiple genes. One of these interaction partners is described as a HIF prolyl hydroxylase, an Fe(II)-dependent oxygenase that me... | |
medium_divergent_branch_00842 | The gene ITCH interacts with multiple partners. One specific interaction involves a WW-domain containing protein where the binding depends on two PPXY motifs located in the N-terminus of the interacting partner. Which disease is associated with this specific interacting partner through genomic alterations? | Charcot-Marie-Tooth disease type 1C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00842","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ITCH interacts with multiple partners. One specific interaction involves a WW-domain containing protein where the binding depends on two PPX... | |
medium_divergent_branch_00843 | KIF3B is associated with multiple biological processes. One of these processes is supported by evidence indicating that KIF3B localizes to various organ tissues and developing neurons in mice, and accumulates with anterogradely moving membranous organelles following nerve axon ligation. Which cellular component is the ... | axon cytoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00843","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF3B is associated with multiple biological processes. One of these processes is supported by evidence indicating that KIF3B localizes to various or... | |
medium_divergent_branch_00844 | CYP3A4 interacts with multiple proteins. One interaction partner is an ER-associated polytopic RING-finger E3 ubiquitin ligase, also known as AMFR, which effectively ubiquitinates CYP3A4 in vitro in a UBC7-dependent manner. Which disease is associated with genomic alterations in this specific interacting protein? | coronary artery disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00844","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CYP3A4 interacts with multiple proteins. One interaction partner is an ER-associated polytopic RING-finger E3 ubiquitin ligase, also known as AMFR, w... | |
medium_divergent_branch_00845 | The gene PPP1CB interacts with multiple partners. One specific interaction is supported by evidence describing a stable multimeric complex (the PTW/PP1 phosphatase complex) composed of the regulatory subunits PNUTS, the target protein, and a PP1 catalytic subunit. Which protein is encoded by the gene that interacts wit... | WD repeat-containing protein 82 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00845","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP1CB interacts with multiple partners. One specific interaction is supported by evidence describing a stable multimeric complex (the PTW/P... | |
medium_divergent_branch_00846 | TRIM31 interacts with multiple genes. One specific interaction is characterized by direct binding that promotes K48-linked polyubiquitination and subsequent proteasomal degradation of the target protein. Which disease is genetically associated with this specific target gene? | iritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00846","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM31 interacts with multiple genes. One specific interaction is characterized by direct binding that promotes K48-linked polyubiquitination and sub... | |
medium_divergent_branch_00847 | ARF4 is associated with multiple biological processes. One association is supported by evidence showing that overexpression of ARF4 in Yeast or U373MG cells reduces reactive oxygen species (ROS) generation in response to Bax or N-(4-hydroxyphenyl)retinamide (4-HPR), respectively, suggesting a role in inhibiting cell de... | regulation of metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00847","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARF4 is associated with multiple biological processes. One association is supported by evidence showing that overexpression of ARF4 in Yeast or U373M... | |
medium_divergent_branch_00848 | The gene GNB3 is associated with multiple biological processes. One association is supported by evidence that GNB3-T/+ mice exhibit elevated fasting plasma glucose, insulin, and C-peptide, along with glucose intolerance, indicative of type 2 diabetes. Which biological process, connected to the process implicated by thi... | hormone metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00848","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GNB3 is associated with multiple biological processes. One association is supported by evidence that GNB3-T/+ mice exhibit elevated fasting ... | |
medium_divergent_branch_00849 | SMAD7 interacts with multiple proteins. One specific interaction is characterized by the partner protein preventing the ubiquitination of SMAD7. Which protein, encoded by the gene connected to SMAD7 via this specific interaction, is the subject of this description? | Ubiquitin carboxyl-terminal hydrolase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00849","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD7 interacts with multiple proteins. One specific interaction is characterized by the partner protein preventing the ubiquitination of SMAD7. Whic... | |
medium_divergent_branch_00850 | SIRT7 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we report that sirtuin 7 (SIRT7) directly deacetylates the target protein and that this deacetylation interferes with the target protein-PRMT5 interaction and suppresses proliferation of human colon cancer HCT116 c... | Methylosome protein WDR77 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00850","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIRT7 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we report that sirtuin 7 (SIRT7) directly d... | |
medium_divergent_branch_00852 | SIGLEC16 is associated with multiple biological processes. One association is supported by evidence stating: 'In contrast, engagement of the activating counterpart Siglec-16 increases elimination of bacteria.' Identify the biological process that is positively regulated by the process linked to SIGLEC16 via this specif... | defense response to bacterium | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00852","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIGLEC16 is associated with multiple biological processes. One association is supported by evidence stating: 'In contrast, engagement of the activati... | |
medium_divergent_branch_00853 | ELL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition, endogenous [protein] also exhibited the capacity to interact with ELL2.' Which protein, connected to ELL2 via an interaction, is the subject of this specific evidence? (Note: The final answer should be the protein nam... | ELL-associated factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00853","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ELL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition, endogenous [protein] also exhibited the capaci... | |
medium_divergent_branch_00854 | Nicastrin (NCSTN) interacts with multiple presenilin proteins. Experimental evidence involving subcellular fractionation of membrane vesicles and coimmunoprecipitation of gamma-secretase components indicates that these protein interactions occur within the Golgi/trans-Golgi network (TGN) compartments. Which protein, en... | Presenilin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00854","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Nicastrin (NCSTN) interacts with multiple presenilin proteins. Experimental evidence involving subcellular fractionation of membrane vesicles and coi... | |
medium_divergent_branch_00855 | HYPK interacts with multiple proteins. One of these interaction partners is characterized by a scaffolding function facilitated by its C-terminal ubiquitin-associated domain and N-terminal tyrosine-type LC3-interacting region, which bind to NEDD8 and LC3, respectively. Which disease is associated with this specific int... | familial Alzheimer disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00855","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HYPK interacts with multiple proteins. One of these interaction partners is characterized by a scaffolding function facilitated by its C-terminal ubi... | |
medium_divergent_branch_00856 | The gene POLB interacts with several protein partners. One specific partner is supported by evidence stating: 'All of these proteins interact with polbetaDelta in vitro and in vivo.' Based on this contextual clue, identify the correct protein partner of POLB and state the name of the protein encoded by this partner gen... | DNA repair protein XRCC1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00856","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene POLB interacts with several protein partners. One specific partner is supported by evidence stating: 'All of these proteins interact with po... | |
medium_divergent_branch_00858 | RAD51AP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show that UAF1 mediates the interaction between this protein and RAD51AP1, and that depletion of this protein or UAF1 led to a decreased stability of RAD51AP1.' Which protein, connected to RAD51AP1 via this specifi... | Ubiquitin carboxyl-terminal hydrolase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00858","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD51AP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show that UAF1 mediates the interaction bet... | |
medium_divergent_branch_00859 | MIR320A is associated with multiple biological processes. One specific association is supported by evidence stating that miR-320a represses IL-4 expression by binding to its 3' untranslated region. Which biological process, linked to the process described by this evidence, is the target of the 'negatively regulates' re... | interleukin-4 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00859","source_qa_id":"medium_divergent_branch_02140","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MIR320A is associated with multiple biological processes. One specific association is supported b... | |
medium_divergent_branch_00860 | CAPN2 interacts with multiple genes. One interaction is supported by evidence stating: 'The best characterized calpains are the ubiquitously expressed mu- and m-calpains, consisting of a common 30 kDa small S-subunit (domains V and VI) and slightly differing 80 kDa large L-subunits (domains I to IV).' Which cell type i... | non-classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00860","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CAPN2 interacts with multiple genes. One interaction is supported by evidence stating: 'The best characterized calpains are the ubiquitously expresse... | |
medium_divergent_branch_00861 | SKP1 interacts with multiple proteins. One of these interaction partners is described as interacting with the Skp1/SCF complex and mediating its recruitment to beta-catenin target promoters in chromatin. Which protein corresponds to this description? | Transformation/transcription domain-associated protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00861","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SKP1 interacts with multiple proteins. One of these interaction partners is described as interacting with the Skp1/SCF complex and mediating its recr... | |
medium_divergent_branch_00862 | The orbitosphenoid cartilage element is classified as a type of two different anatomical structures. One of these parent structures is defined as an orbitosphenoid endochondral element composed primarily of cartilage tissue. Which parent structure corresponds to this definition? | developing mesenchymal condensation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00862","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The orbitosphenoid cartilage element is classified as a type of two different anatomical structures. One of these parent structures is defined as an ... | |
medium_divergent_branch_00863 | Heparin-binding growth-regulated protein (HRG) is associated with multiple biological processes. One association is supported by evidence stating: 'These results suggest that, by binding to factor XIIa, HRG modulates the intrinsic pathway of coagulation, particularly in the vicinity of a thrombus where platelet release... | blood coagulation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00863","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Heparin-binding growth-regulated protein (HRG) is associated with multiple biological processes. One association is supported by evidence stating: 'T... | |
medium_divergent_branch_00864 | The gene A4GNT is associated with multiple biological processes. One association is supported by evidence stating: 'These results indicate that the alpha4GnT is a glycosyltransferase that forms alpha1,4-linked GlcNAc residues, preferentially in O-glycans.' Which biological process, connected to the process described by... | glycoprotein biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00864","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene A4GNT is associated with multiple biological processes. One association is supported by evidence stating: 'These results indicate that the a... | |
medium_divergent_branch_00865 | PRDX4 interacts with multiple proteins. One interaction is supported by evidence stating: 'The ER-localized peroxiredoxin PRDX4 was identified as a prominent proinsulin-interacting protein.' Which protein, connected to PRDX4 via this interaction, is encoded by the gene in question? | Insulin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00865","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRDX4 interacts with multiple proteins. One interaction is supported by evidence stating: 'The ER-localized peroxiredoxin PRDX4 was identified as a p... | |
medium_divergent_branch_00866 | The gene DNAH7 is associated with multiple biological processes. One specific association is supported by evidence stating: 'These studies identify DNAH7 as an inner arm component of human cilia that is synthesized but not assembled in a case of PCD.' Identify the biological process described by this evidence, and then... | axonemal dynein complex assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00866","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DNAH7 is associated with multiple biological processes. One specific association is supported by evidence stating: 'These studies identify D... | |
medium_divergent_branch_00867 | TGFBR1 interacts with multiple proteins. One specific interaction is characterized by the finding that the interacting partner directly binds to transforming growth factor-beta type 1 receptor (TβR1) and impedes TβR1 ubiquitination and degradation. Which protein is encoded by the gene corresponding to this interacting ... | Ubiquitin carboxyl-terminal hydrolase 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00867","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TGFBR1 interacts with multiple proteins. One specific interaction is characterized by the finding that the interacting partner directly binds to tran... | |
medium_divergent_branch_00868 | The gene ACTA1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'The beta-thymosins are intracellular monomeric (G-)actin sequestering proteins forming 1:1 complexes with G-actin.' Identify the disease associated with the gene involved in this specific interaction via a bioma... | diabetes mellitus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00868","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACTA1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'The beta-thymosins are intracellular mon... | |
medium_divergent_branch_00869 | The SRC gene has multiple interacting partners. One specific interaction is supported by evidence showing that Crn7 binds to the partner in vivo and can be phosphorylated by recombinant SRC in vitro. Which gene is this interacting partner? | WASL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00869","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The SRC gene has multiple interacting partners. One specific interaction is supported by evidence showing that Crn7 binds to the partner in vivo and ... | |
medium_divergent_branch_00870 | The gene PRKAR2A interacts with multiple other genes. One of these interacting partners is supported by evidence stating that the protein encoded by this partner gene forms a stable complex with, and is phosphorylated by, PKA. Which protein is encoded by the gene that interacts with PRKAR2A and corresponds to this evid... | E3 ubiquitin-protein ligase Praja-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00870","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PRKAR2A interacts with multiple other genes. One of these interacting partners is supported by evidence stating that the protein encoded by ... | |
medium_divergent_branch_00871 | HNRNPAB interacts with multiple proteins. One interaction is supported by evidence stating: 'By two-hybrid screen we identified several proteins that interact with the p63alpha carboxyl terminus and its sterile alpha-motif, including the apobec-1-binding protein-1 (ABBP1).' Which protein, among those interacting with H... | Tumor protein 63 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00871","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HNRNPAB interacts with multiple proteins. One interaction is supported by evidence stating: 'By two-hybrid screen we identified several proteins that... | |
medium_divergent_branch_00872 | The protein CORO1C is implicated in multiple biological processes. One specific process is supported by evidence showing that morpholinos targeting CORO1C or RCC2, or mutations in the binding sites of the Rac1-RCC2-CORO1C complex, delay the arrival of neural crest derivatives at their correct locations in developing ze... | mesenchymal cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00872","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CORO1C is implicated in multiple biological processes. One specific process is supported by evidence showing that morpholinos targeting C... | |
medium_divergent_branch_00873 | CD2AP interacts with multiple genes. One of these interaction partners is known to form heterotypic complexes with a protein encoded by NCBIGene:30011. Which cellular component is this specific interaction partner located in? | cytoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00873","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD2AP interacts with multiple genes. One of these interaction partners is known to form heterotypic complexes with a protein encoded by NCBIGene:3001... | |
medium_divergent_branch_00874 | S100B interacts with multiple proteins. One of these interaction partners is characterized by binding to S100B-Sepharose beads and being recovered in anti-S100B immunoprecipitates in a strict Ca(2+)- and Zn(2+)-dependent manner. Which protein is encoded by the gene corresponding to this specific interaction partner? | Neuroblast differentiation-associated protein AHNAK | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00874","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"S100B interacts with multiple proteins. One of these interaction partners is characterized by binding to S100B-Sepharose beads and being recovered in... | |
medium_divergent_branch_00876 | LDB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition to known TAL-1 partners, GATA-1, E2A, HEB, LMO2 and Ldb1, we identify the ETO2 repressor as a novel component recruited to TAL-1 complexes through interaction with E2A/HEB.' Which protein, connected to LDB1 via this in... | T-cell acute lymphocytic leukemia protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00876","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LDB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition to known TAL-1 partners, GATA-1, E2A, HEB, LMO2... | |
medium_divergent_branch_00877 | NCOA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In genome-wide screening for steroid receptor coactivator (SRC)-interacting proteins using yeast two-hybrid system, we found that the 20S proteasome beta subunit [interacting partner] (Low Molecular mass Polypeptide 2) interacts ... | Proteasome subunit beta type-9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00877","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In genome-wide screening for steroid receptor coactivator ... | |
medium_divergent_branch_00878 | MCM10 interacts with multiple proteins. One of these interaction partners is identified as the substrate recognition subunit that targets MCM10 for degradation, a discovery made by screening known DDB1-interacting proteins. Which protein is encoded by the gene corresponding to this specific interaction partner? | DDB1- and CUL4-associated factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00878","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCM10 interacts with multiple proteins. One of these interaction partners is identified as the substrate recognition subunit that targets MCM10 for d... | |
medium_divergent_branch_00879 | The gene GRIA4 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Pull-down assays showed that native [protein kinase C gamma type] binds the GluR4 C-terminal membrane-proximal region, and recombinant [protein kinase C gamma type] was retained by GST-GluR4 C-termina... | Protein kinase C gamma type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00879","source_qa_id":"medium_divergent_branch_01063","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene GRIA4 is known to interact with multiple proteins. One specific interaction is supported... | |
medium_divergent_branch_00881 | EEF1G interacts with multiple genes. One of these interactions is supported by evidence stating: 'This peptide was responsible for the specific interaction of CRS with elongation factor-1gamma.' Which disease is associated with the gene identified by this evidence? | microcephaly, developmental delay, and brittle hair syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00881","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EEF1G interacts with multiple genes. One of these interactions is supported by evidence stating: 'This peptide was responsible for the specific inter... | |
medium_divergent_branch_00882 | SPOP interacts with multiple proteins. One interaction is supported by evidence describing the binding mechanism of the SPOP MATH domain with peptides mimicking the phosphatase Puc, the chromatin component MacroH2A, and the dual-specificity phosphatase PTEN. Which protein, among those interacting with SPOP, is encoded ... | Core histone macro-H2A.1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00882","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SPOP interacts with multiple proteins. One interaction is supported by evidence describing the binding mechanism of the SPOP MATH domain with peptide... | |
medium_divergent_branch_00883 | Human orthopneumovirus downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -3.068 and an adjusted p-value of 0.0354. Which protein does that selected gene encode? | TRPM8 channel associated factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00883","source_qa_id":"medium_divergent_branch_02461","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human orthopneumovirus downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_00884 | The gene TRAF3IP2 (Act1) interacts with multiple proteins. One specific interaction is characterized by the finding that Act1 binds to this partner exclusively among the TRAF family of proteins. Which protein is encoded by the gene corresponding to this specific interaction partner? | TNF receptor-associated factor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00884","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TRAF3IP2 (Act1) interacts with multiple proteins. One specific interaction is characterized by the finding that Act1 binds to this partner e... | |
medium_divergent_branch_00885 | FGF19 is involved in a biological process supported by evidence stating: 'Both FGF19 and FGF21 can signal through FGFR1-3 bound by betaKlotho and increase glucose uptake in adipocytes expressing FGFR1.' Which biological process is positively regulated by the process linked to FGF19 in this specific context? | D-glucose import across plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00885","source_qa_id":"medium_divergent_branch_00463","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FGF19 is involved in a biological process supported by evidence stating: 'Both FGF19 and FGF21 ca... | |
medium_divergent_branch_00886 | EIF3D interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Identify the protein corresponding to this evidence, and then determine the protein product encoded by the gene for that interacting par... | Eukaryotic translation initiation factor 3 subunit M | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00886","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF3D interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of c... | |
medium_divergent_branch_00887 | CDK6 is implicated in multiple biological processes. One specific connection is supported by evidence stating that deficiency in this entity prevents the expansion of neuronally committed precursors by lengthening G1 phase duration, thereby reducing the production of newborn neurons. Which biological process, connected... | neurogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00887","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK6 is implicated in multiple biological processes. One specific connection is supported by evidence stating that deficiency in this entity prevents... | |
medium_divergent_branch_00889 | ITPR3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Further, both inositol 1,4,5-trisphosphate receptor-3 and caveolin-1 were immunoprecipitated with DeltaTrp1alpha and Trp1alpha.' Which protein, connected to ITPR3 via an interaction, is encoded by the gene associated with this sp... | Short transient receptor potential channel 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00889","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITPR3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Further, both inositol 1,4,5-trisphosphate receptor-3 and ... | |
medium_divergent_branch_00890 | Kidney granular cells are a subtype of a specific cell class. Evidence for this classification describes the entity as a smooth muscle cell that synthesizes, stores, and secretes the enzyme renin, located in the wall of the afferent arteriole at the entrance to the glomerulus. Although it has a different origin than ot... | kidney cortical cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00890","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Kidney granular cells are a subtype of a specific cell class. Evidence for this classification describes the entity as a smooth muscle cell that synt... | |
medium_divergent_branch_00892 | BRAF interacts with multiple proteins. One specific interaction is described by the following evidence: 'Using a small interfering RNA approach, we demonstrate that C3G is required for the activation of ERKs and Rap1 by cAMP/PKA. This activation requires the GTP-dependent association of Rap1 with B-Raf.' Which disease ... | choroidal neovascularization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00892","source_qa_id":"medium_divergent_branch_06074","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BRAF interacts with multiple proteins. One specific interaction is described by the following evi... | |
medium_divergent_branch_00893 | CDK5 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The 60S ribosomal protein, [interacting partner], was identified as a Cdk5-interacting protein.' Which protein, encoded by the gene corresponding to this interacting partner, is the final answer? | Large ribosomal subunit protein eL34 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00893","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK5 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The 60S ribosomal protein, [interacting partner], ... | |
medium_divergent_branch_00894 | The gene TNFRSF13B (encoding TACI) has multiple protein interaction partners. One specific interaction was identified via yeast two-hybrid screening of a B cell library using the TACI intracellular domain, which revealed that TACI interacts with TNFR-associated factors (TRAF) 2, 5, and 6. Which protein, among those con... | TNF receptor-associated factor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00894","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TNFRSF13B (encoding TACI) has multiple protein interaction partners. One specific interaction was identified via yeast two-hybrid screening ... | |
medium_divergent_branch_00896 | BDNF interacts with multiple proteins. One interaction involves a protein that forms a complex with Huntingtin associated protein-1 (HAP1) and sortilin, playing a crucial role in the intracellular trafficking and stabilization of proBDNF. Which disease is associated with this interacting protein through genomic alterat... | Ischemic stroke | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00896","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BDNF interacts with multiple proteins. One interaction involves a protein that forms a complex with Huntingtin associated protein-1 (HAP1) and sortil... | |
medium_divergent_branch_00900 | AIPL1 interacts with multiple proteins. One of these interaction partners is supported by evidence indicating it interacts with the molecular chaperones Hsp90 and Hsp70. Which protein is this interaction partner? | Heat shock cognate 71 kDa protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00900","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AIPL1 interacts with multiple proteins. One of these interaction partners is supported by evidence indicating it interacts with the molecular chapero... | |
medium_divergent_branch_00901 | HOOK1 interacts with multiple proteins. One specific interaction is supported by evidence stating that 'FTS is associated with a conserved C-terminal motif in Hook proteins in the yeast two-hybrid system and in tissue culture cells, and Hook proteins were found to form homo- and heterodimers.' Which protein, connected ... | FHF complex subunit HOOK-interacting protein 1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00901","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HOOK1 interacts with multiple proteins. One specific interaction is supported by evidence stating that 'FTS is associated with a conserved C-terminal... | |
medium_divergent_branch_00902 | Microglia development is a subtype of a broader biological process. Evidence for this relationship describes the process as: 'The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.' Which biological proces... | glial cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00902","source_qa_id":"medium_divergent_branch_00985","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Microglia development is a subtype of a broader biological process. Evidence for this relationshi... | |
medium_divergent_branch_00903 | MACROH2A1 is associated with multiple biological processes. One association is supported by evidence stating that MACROH2A1 splicing isoforms differentially regulate the transcription of a set of genes involved in redox metabolism. Which biological process, connected to the process supported by this evidence via an 'is... | regulation of response to stress | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00903","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MACROH2A1 is associated with multiple biological processes. One association is supported by evidence stating that MACROH2A1 splicing isoforms differe... |
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