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medium_divergent_branch_00905 | BRCA1 is associated with multiple biological processes. One association is supported by evidence stating: 'We showed here that RNA inhibition-mediated down-regulation of BRCA1 expression induced a marked increase in the fatty acid synthesis.' Identify the biological process that is connected to this specific BRCA1-asso... | fatty acid biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00905","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRCA1 is associated with multiple biological processes. One association is supported by evidence stating: 'We showed here that RNA inhibition-mediate... | |
medium_divergent_branch_00906 | CLASP2 is associated with multiple biological processes. One association is supported by evidence stating: 'Together, these results provide evidence for involvement of the microtubule plus-end tracking protein CLASP2 in cytoskeleton-related mechanisms underlying neuronal polarity and interplay between microtubule stabi... | cytoskeleton organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00906","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLASP2 is associated with multiple biological processes. One association is supported by evidence stating: 'Together, these results provide evidence ... | |
medium_divergent_branch_00907 | The gene FCGR2B is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'The inhibitory receptor FcγRIIB plays a central role in regulating the generation of autoantibodies and their effector functions, which include activation of i... | immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00907","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FCGR2B is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidenc... | |
medium_divergent_branch_00909 | TRIM21 interacts with multiple proteins. One specific interaction is modulated by phosphorylation, which inhibits the binding between the ubiquitin E3 ligase TRIM21 and its partner, thereby preventing TRIM21-mediated K99/102 polyubiquitylation and subsequent degradation of that partner. Which protein, encoded by the ge... | Leukocyte surface antigen CD47 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00909","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM21 interacts with multiple proteins. One specific interaction is modulated by phosphorylation, which inhibits the binding between the ubiquitin E... | |
medium_divergent_branch_00910 | The biological process 'regulation of glomerular filtration' is associated with multiple anatomical structures. One such structure is described as blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as ... | renal corpuscle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00910","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process 'regulation of glomerular filtration' is associated with multiple anatomical structures. One such structure is described as bl... | |
medium_divergent_branch_00911 | T cell-mediated cytotoxicity is enabled by more than one type of cell. One of these cells is described as a CD8-positive, alpha-beta T cell capable of killing target cells in an antigen-specific manner, exhibiting a perforin-positive and granzyme B-positive phenotype. Which cell type does this specific cytotoxic lympho... | activated CD8-positive, alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00911","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"T cell-mediated cytotoxicity is enabled by more than one type of cell. One of these cells is described as a CD8-positive, alpha-beta T cell capable o... | |
medium_divergent_branch_00912 | ANKRD13D is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that Ankrd13 proteins are anchored, via their central region and UIMs, to this component, where they colocalize with EGFR. Which cellular component is connected to this s... | cell periphery | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00912","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANKRD13D is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating... | |
medium_divergent_branch_00913 | FGFR1 interacts with multiple proteins. One specific interaction involves a substrate containing an SH2 domain, identified as a specific phospholipase C gamma isoform, which associates with phosphorylated FGFR1 heterodimers but is phosphorylated only in the presence of the type 1 kinase homodimer. Which protein is enco... | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00913","source_qa_id":"medium_divergent_branch_04382","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FGFR1 interacts with multiple proteins. One specific interaction involves a substrate containing ... | |
medium_divergent_branch_00914 | SOX15 is involved in multiple biological processes. One of these processes is supported by evidence stating that Sox15 mutant mice display perturbed skeletal muscle regeneration, due in part to decreased numbers of satellite cells and decreased Foxk1 expression. Which biological process is positively regulated by the s... | satellite cell activation involved in skeletal muscle regeneration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00914","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX15 is involved in multiple biological processes. One of these processes is supported by evidence stating that Sox15 mutant mice display perturbed ... | |
medium_divergent_branch_00915 | DMPK interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we identified a novel member of the sHSP family that associates specifically with myotonic dystrophy protein kinase (DMPK).' Which disease is connected to this specific interacting gene through a biomarker relationship? | atrial fibrillation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00915","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DMPK interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we identified a novel member of the sHSP family that ass... | |
medium_divergent_branch_00916 | CSNK2A2 interacts with multiple proteins. One specific interaction is characterized by the finding that the proteins interact in vitro and in cells via non-overlapping domains. Which protein product is encoded by the gene corresponding to this specific interacting partner? | FACT complex subunit SPT16 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00916","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CSNK2A2 interacts with multiple proteins. One specific interaction is characterized by the finding that the proteins interact in vitro and in cells v... | |
medium_divergent_branch_00917 | PSEN1 interacts with multiple genes. One of these interacting partners is described in evidence stating that TRAF6 recruited PS1 to the TβRI complex and promoted lysine-63-linked polyubiquitination of PS1, which activated PS1. Which disease is connected to this specific interacting gene through a biomarker relationship... | systemic sclerosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00917","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSEN1 interacts with multiple genes. One of these interacting partners is described in evidence stating that TRAF6 recruited PS1 to the TβRI complex ... | |
medium_divergent_branch_00918 | COPS4 interacts with multiple proteins. One of these interaction partners is noted to also interact with the CSN4-6-7 core. Which protein product is encoded by this specific interaction partner? | COP9 signalosome complex subunit 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00918","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COPS4 interacts with multiple proteins. One of these interaction partners is noted to also interact with the CSN4-6-7 core. Which protein product is ... | |
medium_divergent_branch_00919 | PAK1 interacts with multiple genes. One of these interaction partners is described in a study stating: 'We show that SAD-A directly binds to PAK1 through its kinase domain.' Which disease is associated with this interaction partner via a biomarker relationship? | colorectal carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00919","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAK1 interacts with multiple genes. One of these interaction partners is described in a study stating: 'We show that SAD-A directly binds to PAK1 thr... | |
medium_divergent_branch_00921 | YME1L1 is associated with multiple biological processes. One association is supported by evidence that impaired YME1L1 function leads to proliferation defects and mitochondrial network fragmentation due to abnormal processing of OPA1. Which biological process, connected to the process implicated by this evidence via an... | organelle organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00921","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"YME1L1 is associated with multiple biological processes. One association is supported by evidence that impaired YME1L1 function leads to proliferatio... | |
medium_divergent_branch_00922 | The gene SLC9A1 is enriched in multiple cell types. One specific cell type shows a mean expression of 4.18 TPM, a z-score of 1.65, and a fold enrichment of 2.42. Which cell type corresponds to these statistics, and what is its direct parent category in the cell type hierarchy (i.e., what is it a type of)? | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00922","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SLC9A1 is enriched in multiple cell types. One specific cell type shows a mean expression of 4.18 TPM, a z-score of 1.65, and a fold enrichm... | |
medium_divergent_branch_00923 | SRGAP2C is associated with multiple biological processes. One specific association is supported by evidence showing that SRGAP2C expression in mice increases the density of excitatory and inhibitory synapses received by layer 2/3 pyramidal neurons. Which biological process, connected to this specific process via an 'is... | synapse assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00923","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SRGAP2C is associated with multiple biological processes. One specific association is supported by evidence showing that SRGAP2C expression in mice i... | |
medium_divergent_branch_00924 | NOS1 interacts with multiple proteins. One interaction partner is characterized by evidence stating that a specific protein interacts with the nNOS PDZ domain through its C terminus. Which protein is encoded by the gene corresponding to this specific interaction partner? | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00924","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOS1 interacts with multiple proteins. One interaction partner is characterized by evidence stating that a specific protein interacts with the nNOS P... | |
medium_divergent_branch_00925 | The gene NELFCD is associated with multiple protein partners via binding interactions. One specific interaction is supported by evidence stating that NELF-B and NELF-C or NELF-D are integral subunits that bring NELF-A and a specific partner protein together, and that coexpression of these four proteins in insect cells ... | Negative elongation factor E | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00925","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NELFCD is associated with multiple protein partners via binding interactions. One specific interaction is supported by evidence stating that... | |
medium_divergent_branch_00926 | The gene GNB3 is associated with multiple biological processes. One association is supported by evidence showing that Ucp1 expression is significantly lower in white adipose tissue (WAT) in GNB3-T/+ mice, suggesting WAT remodeling and impaired cellular thermogenesis. Which biological process, connected to the process s... | regulation of macromolecule biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00926","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GNB3 is associated with multiple biological processes. One association is supported by evidence showing that Ucp1 expression is significantl... | |
medium_divergent_branch_00927 | ATP13A2 is associated with multiple biological processes. One association is supported by evidence stating: 'Mechanistically, ATP13A2 facilitated recruitment of HDAC6 and cortactin to lysosomes.' Which biological process is a parent term (is_a) of the process described by this evidence? | protein localization to vacuole | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00927","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATP13A2 is associated with multiple biological processes. One association is supported by evidence stating: 'Mechanistically, ATP13A2 facilitated rec... | |
medium_divergent_branch_00928 | hsa-miR-223-3p regulates more than one cell type. Experimental evidence indicates that hsa-miR-223, which is enriched in a specific cell type, down-regulates the expression of LMO2. Which anatomical structure is the cell type enriched in hsa-miR-223 a part of? | B cell domain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00928","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-223-3p regulates more than one cell type. Experimental evidence indicates that hsa-miR-223, which is enriched in a specific cell type, down-r... | |
medium_divergent_branch_00929 | The gene PKM is associated with multiple interacting partners. One specific interaction involves a partner that directly binds to pyruvate kinase muscle isozyme (PKM)2 to modulate metabolic flux in cancer cells. Which protein is encoded by the gene corresponding to this specific interacting partner? | Bifunctional peptidase and arginyl-hydroxylase JMJD5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00929","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PKM is associated with multiple interacting partners. One specific interaction involves a partner that directly binds to pyruvate kinase mus... | |
medium_divergent_branch_00930 | BRCA2 interacts with multiple genes. One of these interaction partners is described in experimental evidence as 'an effector of Rho small GTPase' to which BRCA2 binding was detected. Which disease is associated with this specific interaction partner through genomic alterations? | overactive bladder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00930","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRCA2 interacts with multiple genes. One of these interaction partners is described in experimental evidence as 'an effector of Rho small GTPase' to ... | |
medium_divergent_branch_00931 | The gene C19orf12 is associated with multiple biological processes. One association is supported by evidence showing that fibroblasts from a patient exhibited high mitochondrial calcium concentration and increased H2O2-induced apoptosis compared to controls. Which broader biological process is the specific process link... | intracellular calcium ion homeostasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00931","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene C19orf12 is associated with multiple biological processes. One association is supported by evidence showing that fibroblasts from a patient ... | |
medium_divergent_branch_00932 | Interleukin-17 production is enabled by multiple cell types. One such cell type is described as a CD8-positive, alpha-beta T cell with the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFN-gamma. What is the immediate parent class (is_a relationship) of thi... | CD8-positive, alpha-beta cytokine secreting effector T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00932","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interleukin-17 production is enabled by multiple cell types. One such cell type is described as a CD8-positive, alpha-beta T cell with the phenotype ... | |
medium_divergent_branch_00933 | DIS3 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which disease is associated with the gene linked to DIS3 via this specific evidence? | retinitis pigmentosa-hearing loss-premature aging-short stature-facial dysmorphism syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00933","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DIS3 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we demonstrate the association of two different Dis3p ho... | |
medium_divergent_branch_00934 | ZBTB16 (PLZF) interacts with multiple proteins. One interaction is characterized by the following evidence: 'It appears that the nuclear receptor corepressor/histone deacetylase corepressor complex interacts directly in an ATRA-insensitive manner with the BTB/POZ-domain of the wild-type PLZF protein and is required, at... | Nuclear receptor corepressor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00934","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZBTB16 (PLZF) interacts with multiple proteins. One interaction is characterized by the following evidence: 'It appears that the nuclear receptor cor... | |
medium_divergent_branch_00936 | The gene EEF1B2 interacts with multiple other genes. One specific interaction is supported by experimental evidence stating: 'Among the 80 tested pairs, leucyl- and histidyl-tRNA synthetases were found to make strong and specific interaction with the EF-1gamma and beta while glu-proly-, glutaminyl-, alanyl-, aspartyl-,... | Histidine--tRNA ligase, cytoplasmic | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00936","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EEF1B2 interacts with multiple other genes. One specific interaction is supported by experimental evidence stating: 'Among the 80 tested pai... | |
medium_divergent_branch_00937 | HOOK2 interacts with multiple proteins. One interaction partner is supported by evidence stating that 'Hook proteins were found to form homo- and heterodimers.' Which protein is encoded by the gene corresponding to this specific interaction partner? | Protein Hook homolog 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00937","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HOOK2 interacts with multiple proteins. One interaction partner is supported by evidence stating that 'Hook proteins were found to form homo- and het... | |
medium_divergent_branch_00938 | CARM1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we report that protein arginine methyltransferase 4 (PRMT4 or CARM1) dimethylates a histone demethylase at R838, which promotes the binding of the deubiquitinase USP7, resulting in the deubiquitination and stabilization of thi... | gallbladder carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00938","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CARM1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we report that protein arginine methyltransferase 4 (PR... | |
medium_divergent_branch_00939 | GABARAPL2 interacts with multiple proteins. One interaction partner was identified via yeast two-hybrid screening as GATE-16, which regulates Golgi SNARE of 28kDa (GS28) function and stability and plays a role in autophagosome biogenesis. Which protein corresponds to this interaction partner? | Oxysterol-binding protein-related protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00939","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABARAPL2 interacts with multiple proteins. One interaction partner was identified via yeast two-hybrid screening as GATE-16, which regulates Golgi S... | |
medium_divergent_branch_00940 | The protein EIF4B is associated with multiple molecular functions. One of these functions is supported by evidence stating: 'The amino-terminal domain of eIF-4B contains a consensus [function-related] domain present in a number of other [function-related] proteins.' Which molecular function, connected to EIF4B via an '... | nucleic acid binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00940","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein EIF4B is associated with multiple molecular functions. One of these functions is supported by evidence stating: 'The amino-terminal domai... | |
medium_divergent_branch_00941 | The biological process 'regulation of branching involved in ureteric bud morphogenesis' is defined as any process that modulates the rate, frequency, or extent of branching involved in ureteric bud morphogenesis. This definition notes that the ureteric bud is an epithelial tube that grows out from the metanephric duct ... | regulation of developmental process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00941","source_qa_id":"medium_divergent_branch_00044","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of branching involved in ureteric bud morphogenesis' is define... | |
medium_divergent_branch_00942 | COPS4 interacts with multiple proteins. One interaction is supported by evidence describing the purification of the human CSN complex from a stable 293 cell line expressing an N-terminal HBTH-tagged subunit of the gene corresponding to this specific interacting partner, achieved via high-affinity streptavidin binding a... | COP9 signalosome complex subunit 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00942","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COPS4 interacts with multiple proteins. One interaction is supported by evidence describing the purification of the human CSN complex from a stable 2... | |
medium_divergent_branch_00943 | PTK2 interacts with multiple genes. One of these interacting partners is reported to form a complex with focal adhesion kinase and p130Cas in MDA-MB-468 cells. Which disease is associated with this specific interacting gene via a biomarker relationship? | thyrotoxicosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00943","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTK2 interacts with multiple genes. One of these interacting partners is reported to form a complex with focal adhesion kinase and p130Cas in MDA-MB-... | |
medium_divergent_branch_00944 | SMARCA4 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'In this study, we show that this protein interacts with the SWI/SNF chromatin-remodeling protein BRG1 to regulate E-cadherin independently of CtBP, its traditional co-repressor.' What is the full name of the pr... | Zinc finger E-box-binding homeobox 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00944","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMARCA4 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'In this study, we show that this protei... | |
medium_divergent_branch_00945 | Human polyomavirus 1 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.146 and an adjusted p-value of 0.02. Which protein does that selected gene encode? | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00945","source_qa_id":"medium_divergent_branch_01701","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human polyomavirus 1 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_00949 | GEMIN6 interacts with multiple proteins. One of these interaction partners is described by evidence stating: 'Binding experiments show that this protein interacts directly with SMN and GEMIN6 and mediates the association of GEMIN6 with the SMN complex.' Which protein, connected to GEMIN6 via a binding interaction, matc... | Gem-associated protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00949","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GEMIN6 interacts with multiple proteins. One of these interaction partners is described by evidence stating: 'Binding experiments show that this prot... | |
medium_divergent_branch_00950 | DNMT1 interacts with multiple genes. One of these interacting partners is a kinase that colocalizes with and directly interacts with DNMT1, specifically phosphorylating it at Serine 143. Which disease is associated with this specific interacting gene as a therapeutic target? | pulmonary hypertension | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00950","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNMT1 interacts with multiple genes. One of these interacting partners is a kinase that colocalizes with and directly interacts with DNMT1, specifica... | |
medium_divergent_branch_00951 | FRS2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Importantly, we demonstrate that the phosphotyrosine binding domain of FRS-2 directly binds the Trk receptors at the same phosphotyrosine residue that binds the signaling adapter Shc.' Which protein, encoded by the gene i... | NT-3 growth factor receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00951","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FRS2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Importantly, we demonstrate that the phosphotyrosi... | |
medium_divergent_branch_00953 | ROCK1 is associated with multiple biological processes. One association is supported by evidence stating: 'These data suggest that ROCK1 and ROCK2 play distinct roles in regulating keratinocyte adhesion and terminal differentiation.' Identify the biological process linked to this specific association via an 'is a' rela... | regulation of epidermal cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00953","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ROCK1 is associated with multiple biological processes. One association is supported by evidence stating: 'These data suggest that ROCK1 and ROCK2 pl... | |
medium_divergent_branch_00954 | PKN1 interacts with multiple proteins. One specific interaction is supported by evidence showing that FLAG-tagged PKN1 was co-immunoprecipitated with endogenous copies of the interacting protein from HEK293 cell lysates. Furthermore, in vitro binding assays using deletion mutants demonstrated that PKN1 directly binds t... | TNF receptor-associated factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00954","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PKN1 interacts with multiple proteins. One specific interaction is supported by evidence showing that FLAG-tagged PKN1 was co-immunoprecipitated with... | |
medium_divergent_branch_00955 | SMC2 interacts with multiple genes. One interaction is supported by evidence stating: 'The hCAP-E polypeptide, a member of the Structural Maintenance of Chromosomes (SMC) super-family of proteins, coimmunoprecipitates from cell extracts with DNA ligase IV.' Which protein is encoded by the gene that interacts with SMC2 ... | DNA ligase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00955","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMC2 interacts with multiple genes. One interaction is supported by evidence stating: 'The hCAP-E polypeptide, a member of the Structural Maintenance... | |
medium_divergent_branch_00956 | ZMYND11 interacts with multiple gene products. One interaction is characterized by structural studies showing that H3.3-dependent recognition is mediated by the encapsulation of the H3.3-specific 'Ser 31' residue in a composite pocket formed by the tandem bromo-PWWP domains of ZMYND11. Which protein is encoded by the g... | Histone H3.3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00956","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZMYND11 interacts with multiple gene products. One interaction is characterized by structural studies showing that H3.3-dependent recognition is medi... | |
medium_divergent_branch_00957 | SF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The mammalian ortholog (mBBP/SF1) also binds specifically to branchpoint sequences and interacts with the well studied mammalian splicing factor [protein encoded by the gene in question], which binds to the adjacent polypyrimidine ... | Splicing factor U2AF 65 kDa subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00957","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The mammalian ortholog (mBBP/SF1) also binds specifically to... | |
medium_divergent_branch_00958 | NASP interacts with multiple proteins. One of these interaction partners is described in the evidence as binding to the non-nucleosomal histone chaperone NASP. Which protein is this interaction partner? | Putative E3 ubiquitin-protein ligase UBR7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00958","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NASP interacts with multiple proteins. One of these interaction partners is described in the evidence as binding to the non-nucleosomal histone chape... | |
medium_divergent_branch_00961 | Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.725 and an adjusted p-value of 0.022. Which protein does that selected gene encode? | Probable G-protein coupled receptor 34 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00961","source_qa_id":"medium_divergent_branch_03369","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one bra... | |
medium_divergent_branch_00962 | A neuron is a type of cell. Evidence for this classification states: 'The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.' Based on this description, which broader cell category is the neuro... | electrically active cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00962","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"A neuron is a type of cell. Evidence for this classification states: 'The basic cellular unit of nervous tissue. Each neuron consists of a body, an a... | |
medium_divergent_branch_00963 | The AIRE protein interacts with multiple partners. One specific interaction is characterized by the following evidence: 'By the combined use of biochemical and biophysical methods, we show that AIRE selectively interacts with histone H3 through its first plant homeodomain (PHD) finger (AIRE-PHD1) and preferentially bin... | squamous cell lung carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00963","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The AIRE protein interacts with multiple partners. One specific interaction is characterized by the following evidence: 'By the combined use of bioch... | |
medium_divergent_branch_00964 | The gene CHP1 interacts with multiple other genes. One of these interaction partners is supported by evidence stating that rCHP2 binds to the juxtamembrane region of plasma membrane-type NHE isoforms (NHE1-5) in vivo and in vitro, as well as to rCHP1 (the original rat CHP). Which protein is encoded by the gene that int... | Sodium/hydrogen exchanger 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00964","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CHP1 interacts with multiple other genes. One of these interaction partners is supported by evidence stating that rCHP2 binds to the juxtame... | |
medium_divergent_branch_00965 | TTBK1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'It is specifically expressed in the brain, especially in the cytoplasm of cortical and hippocampal neurons.' Which cellular component is connected to the component supported by thi... | somatodendritic compartment | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00965","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TTBK1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'It is spe... | |
medium_divergent_branch_00966 | TRIM21 interacts with multiple genes. One of these interaction partners is an E3 ubiquitin ligase that acts on MAVS; evidence indicates this partner promotes the association of TRIM21 with MAVS in a dose-dependent manner, facilitates K27-linked polyubiquitination of MAVS, and recruits TBK1 to enhance the IFN signaling ... | T-cell non-Hodgkin lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00966","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM21 interacts with multiple genes. One of these interaction partners is an E3 ubiquitin ligase that acts on MAVS; evidence indicates this partner ... | |
medium_divergent_branch_00967 | DIS3L interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, a proteomic analysis of immunoaffinity-purified human exosome complexes identified a novel exosome-associated exoribonuclease, human Dis3-like exonuclease 1 (hDis3L1), which was confirmed to associate with the exosome core ... | Exosome complex component RRP40 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00967","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DIS3L interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, a proteomic analysis of immunoaffinity-purified huma... | |
medium_divergent_branch_00968 | CLN3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'In vitro binding and immunoprecipitation assays show that the interacting protein interacts with the C-terminal region of CLN3 and the increase of Ca(2+) concentration in vitro and in cells causes significant dissociation of... | papilloma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00968","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLN3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'In vitro binding and immunoprecipitation assays show ... | |
medium_divergent_branch_00969 | HIST1H3B interacts with multiple proteins. One of these interaction partners contains a PHD-Bromo region whose three-dimensional structure reveals a single functional unit for the combinatorial recognition of unmodified H3K4 (H3K4me0) and acetylated H3K23 (H3K23ac) within the same histone tail. Which protein is encoded... | Transcription intermediary factor 1-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00969","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIST1H3B interacts with multiple proteins. One of these interaction partners contains a PHD-Bromo region whose three-dimensional structure reveals a ... | |
medium_divergent_branch_00970 | ALDOA is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that aldolase A binds to actin filaments within stress fibers. Which cellular component, connected to this specific location via an 'is a' relationship, represents the broad... | cytoskeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00970","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ALDOA is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating th... | |
medium_divergent_branch_00971 | ATF2 interacts with multiple proteins. One specific interaction partner is distinguished by the fact that the HB16 protein can form a complex with it, but not with c-Fos. Which protein, encoded by the gene connected to ATF2 via this specific binding interaction, is the subject of this distinction? | Transcription factor Jun | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00971","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATF2 interacts with multiple proteins. One specific interaction partner is distinguished by the fact that the HB16 protein can form a complex with it... | |
medium_divergent_branch_00972 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.273 and an adjusted p-value of 0.00111. For which disease is that selected gene recorded as a biomarker? | ulcerative colitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00972","source_qa_id":"medium_divergent_branch_06904","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_00973 | CHMP2A interacts with multiple proteins. One specific interaction involves CHMP2A being directed to the forming nuclear envelope through binding to a partner protein, an event essential for nuclear envelope reformation. Which protein, encoded by the gene connected to CHMP2A via this specific binding interaction, is the... | Charged multivesicular body protein 4b | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00973","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHMP2A interacts with multiple proteins. One specific interaction involves CHMP2A being directed to the forming nuclear envelope through binding to a... | |
medium_divergent_branch_00974 | The biological process 'negative regulation of immune response' is enabled by multiple cell types. One of these cell types is described in the evidence as 'A macrophage that suppresses immune responses.' Which parent cell type is this specific cell a subclass of (is_a)? | elicited macrophage | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00974","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process 'negative regulation of immune response' is enabled by multiple cell types. One of these cell types is described in the eviden... | |
medium_divergent_branch_00975 | ALPK2 is associated with multiple biological processes. One association is supported by evidence stating: 'By intersecting gene expression and loss-of-function siRNA screens we identified Alpha Protein Kinase 2 (ALPK2) as a candidate negative regulator of WNT/β-catenin signaling in cardiogenesis.' Which biological proc... | heart development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00975","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ALPK2 is associated with multiple biological processes. One association is supported by evidence stating: 'By intersecting gene expression and loss-o... | |
medium_divergent_branch_00976 | SUV39H1 is associated with multiple cellular components via a 'located in' relationship. One of these associations is supported by evidence stating that SUV39H1 is the principal enzyme responsible for the accumulation of histone H3 containing a tri-methyl group at its lysine 9 position (H3K9me3) within that specific co... | chromosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00976","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUV39H1 is associated with multiple cellular components via a 'located in' relationship. One of these associations is supported by evidence stating t... | |
medium_divergent_branch_00977 | CARD9 is associated with multiple biological processes. One association is supported by evidence stating: 'Taken together, our data highlight the critical role of CARD9-dependent neutrophil trafficking into the CNS and provide novel insight into the CNS fungal susceptibility of CARD9-deficient humans.' Which biological... | myeloid leukocyte mediated immunity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00977","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CARD9 is associated with multiple biological processes. One association is supported by evidence stating: 'Taken together, our data highlight the cri... | |
medium_divergent_branch_00978 | LRPAP1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Using RAP affinity chromatography, we have purified a novel approximately 250-kDa brain protein and isolated the corresponding cDNA.' Which gene, connected to LRPAP1 via an interaction, is the subject of this specific evi... | AURKA | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00978","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRPAP1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Using RAP affinity chromatography, we have purifie... | |
medium_divergent_branch_00979 | FANCD2 interacts with multiple genes. One of these interacting partners has been shown to colocalize and co-immunoprecipitate with FANCD2 following treatment with DNA crosslinkers or agents that induce replication arrest. Which disease is associated with this specific interacting gene? | adrenal gland neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00979","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCD2 interacts with multiple genes. One of these interacting partners has been shown to colocalize and co-immunoprecipitate with FANCD2 following t... | |
medium_divergent_branch_00980 | KIF22 interacts with multiple proteins. One interaction is supported by evidence stating: 'Now, using the two-hybrid system, we identified two new SIAH interacting proteins: Kid (kinesin like DNA binding protein) and alpha-tubulin.' Which protein, connected to KIF22 via this interaction, is the gene that encodes the pr... | E3 ubiquitin-protein ligase SIAH1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00980","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF22 interacts with multiple proteins. One interaction is supported by evidence stating: 'Now, using the two-hybrid system, we identified two new SI... | |
medium_divergent_branch_00981 | ATF5 interacts with multiple proteins. Evidence for one specific interaction comes from a yeast-based genetic assay designed to identify proteins interacting with a human protein, which yielded three cDNAs encoding bZIP DNA binding motifs. Two of these identified interactants are repressors of cyclic AMP (cAMP)-induced... | Ubiquitin-conjugating enzyme E2 R1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00981","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATF5 interacts with multiple proteins. Evidence for one specific interaction comes from a yeast-based genetic assay designed to identify proteins int... | |
medium_divergent_branch_00982 | RAD18 interacts with multiple proteins. One specific interaction involves a partner that recruits RAD18 to certain structures, leading to the ubiquitination of the replication factor PCNA. Which protein is encoded by the gene corresponding to this interacting partner? | Protein mono-ADP-ribosyltransferase PARP10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00982","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD18 interacts with multiple proteins. One specific interaction involves a partner that recruits RAD18 to certain structures, leading to the ubiquit... | |
medium_divergent_branch_00983 | BTK interacts with multiple proteins. One interaction partner is characterized by evidence stating: 'Association of the SH3 domain of Btk with p120cbl provides evidence for an analogous role for p120cbl in B cell signaling pathways.' Which disease is connected to this specific interaction partner through a biomarker re... | uniparental disomy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00983","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BTK interacts with multiple proteins. One interaction partner is characterized by evidence stating: 'Association of the SH3 domain of Btk with p120cb... | |
medium_divergent_branch_00984 | USP39 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'In HCC cells, USP39 interacts with and is deacetylated by the lysine deacetylase [interaction partner].' Which protein product is encoded by the gene corresponding to this interaction partner? | NAD-dependent protein deacetylase sirtuin-7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00984","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP39 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'In HCC cells, USP39 interacts with and ... | |
medium_divergent_branch_00985 | FANCD2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation with purified proteins indicates that the interacting partner binds to FANCD2 through its C-terminal amino acid 1001-1328 fragment.' Which disease is associated with the gene encoding this interac... | Fanconi anemia complementation group C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00985","source_qa_id":"medium_divergent_branch_02643","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FANCD2 interacts with multiple proteins. One specific interaction is supported by evidence statin... | |
medium_divergent_branch_00986 | RABEPK interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that p40, a Rab9 effector reported previously to bind Rab9-GTP and stimulate endosome-to-TGN transport, interacts with this protein as determined by yeast two-hybrid assays, glutathione S-transferase (GST) pull-do... | 1-phosphatidylinositol 3-phosphate 5-kinase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00986","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RABEPK interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that p40, a Rab9 effector reported previou... | |
medium_divergent_branch_00987 | The gene IKBKB interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'Moreover, endogenous PKCtheta physically associates with activated IKK complexes in CD3/CD28-costimulated primary CD4(+) T cells.' Which protein is encoded by the gene that interacts with IKBKB and i... | Protein kinase C theta type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00987","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IKBKB interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'Moreover, endogenous PKCthet... | |
medium_divergent_branch_00988 | DTX3 interacts with multiple proteins. One interaction is supported by evidence stating: 'A novel E3 ligase for this protein was identified by yeast two-hybrid (Y2H) screening, and DTX3 promoted the ubiquitination and degradation of this protein.' Which protein, connected to DTX3 via this specific interaction evidence,... | Neurogenic locus notch homolog protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00988","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DTX3 interacts with multiple proteins. One interaction is supported by evidence stating: 'A novel E3 ligase for this protein was identified by yeast ... | |
medium_divergent_branch_00989 | The MYC protein physically interacts with multiple partners. One specific interaction involves a partner described as a signal transducer involved in TGF-beta signaling. Which protein is encoded by the gene corresponding to this specific MYC-interacting partner? | SMAD family member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00989","source_qa_id":"medium_divergent_branch_06960","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The MYC protein physically interacts with multiple partners. One specific interaction involves a ... | |
medium_divergent_branch_00992 | COL2A1 interacts with multiple genes. One interaction is supported by evidence stating: 'All radiolabeled PDGF isoforms specifically interacted with type I, II, III, IV, V, and VI collagens (preferential binding to types III, I, VI, and IV) and their constituent chains, either when immobilized on polystyrene or blotted... | classic familial adenomatous polyposis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00992","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COL2A1 interacts with multiple genes. One interaction is supported by evidence stating: 'All radiolabeled PDGF isoforms specifically interacted with ... | |
medium_divergent_branch_00993 | ITGB3BP interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, we demonstrate that beta3-endonexin, a molecule known to associate with the integrin beta3 cytoplasmic domain, specifically binds cyclin A.' Which protein is encoded by the gene connected to ITGB3BP via this specifi... | Cyclin-A2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00993","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGB3BP interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, we demonstrate that beta3-endonexin, a molec... | |
medium_divergent_branch_00994 | GPAA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We also demonstrate that PIG-S and a specific protein form a protein complex with GAA1 and GPI8, and that this specific protein maintains the complex by stabilizing the expression of GAA1 and GPI8.' Which protein, among those int... | GPI-anchor transamidase component PIGT | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00994","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPAA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We also demonstrate that PIG-S and a specific protein form... | |
medium_divergent_branch_00997 | REC8 interacts with multiple proteins. Experimental evidence indicates that REC8 associates with other cohesin proteins, specifically SMC1beta (a meiosis-specific protein) and another partner, as well as with the synaptonemal complex component SCP3, but does not associate with SMC1alpha. Which protein, connected to REC... | Structural maintenance of chromosomes protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00997","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"REC8 interacts with multiple proteins. Experimental evidence indicates that REC8 associates with other cohesin proteins, specifically SMC1beta (a mei... | |
medium_divergent_branch_00998 | The small intestine is a type of anatomy. One specific anatomical category is defined as the structure connecting the stomach to the large intestine, where most digestion and absorption occur (excluding ruminants). This structure is long, coiled, and histologically divided into the duodenum, jejunum, and ileum. Which b... | digestive tract | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00998","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The small intestine is a type of anatomy. One specific anatomical category is defined as the structure connecting the stomach to the large intestine,... | |
medium_divergent_branch_00999 | TOPORS interacts with multiple genes. One of these interaction partners is characterized by evidence stating: 'By analyzing the interactome of the UAS domain of this protein, we identified that it also interacts with the RING domain of the E3 TOPORS and similarly regulates its E3 ubiquitin ligase activity by impairing ... | VCP-NPL4-UFD1 AAA ATPase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00999","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TOPORS interacts with multiple genes. One of these interaction partners is characterized by evidence stating: 'By analyzing the interactome of the UA... | |
medium_divergent_branch_01000 | BCAS2 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that both the BCAS2 and PSO4 subunits of the PSO4 complex directly interact and colocalize with replication protein A (RPA).' Which disease is associated with the gene that interacts with BCAS2 in this context? | leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01000","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCAS2 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that both the BCAS2 and PSO4 subunits of the PSO... | |
medium_divergent_branch_01001 | USP13 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that mass spectrometry analysis of dual-affinity purifications identified the USP13 deubiquitinase as a novel cohesin-interacting protein.' Which disease is associated with the cohesin subunit implied by this inter... | Cornelia de Lange syndrome 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01001","source_qa_id":"medium_divergent_branch_04204","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"USP13 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here w... | |
medium_divergent_branch_01002 | MAPK9 interacts with multiple genes. One of these interacting partners is described in evidence stating: 'Full-length [interacting partner] containing combined D1/D2 mutations was compromised for binding to JNK1 and exhibited reduced JNK1 kinase activity when compared with wild-type [interacting partner].' Which diseas... | colon adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01002","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK9 interacts with multiple genes. One of these interacting partners is described in evidence stating: 'Full-length [interacting partner] containin... | |
medium_divergent_branch_01003 | ZBTB16 (also known as PLZF) interacts with multiple genes. One specific interaction is supported by evidence stating: 'We screened IL-32α-interacting proteins in a human spleen cDNA library using the yeast two-hybrid assay, and investigated the functional relevance of the interaction between IL-32α and PLZF.' Which dis... | polycystic ovary syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01003","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZBTB16 (also known as PLZF) interacts with multiple genes. One specific interaction is supported by evidence stating: 'We screened IL-32α-interacting... | |
medium_divergent_branch_01004 | FOXP3 is associated with multiple biological processes. One specific association is supported by evidence showing that FOXP3-transduced T cells exhibit impaired proliferation, reduced production of cytokines including IL-2 and IL-10, up-regulated expression of regulatory T cell markers such as CD25 and CTLA-4, and supp... | T cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01004","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXP3 is associated with multiple biological processes. One specific association is supported by evidence showing that FOXP3-transduced T cells exhib... | |
medium_divergent_branch_01005 | USP20 interacts with multiple proteins. One specific interaction is characterized by the fact that USP20 interacts with and deubiquitinates a specific mitogen-activated protein kinase. Which protein corresponds to this specific interaction partner? | Mitogen-activated protein kinase 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01005","source_qa_id":"medium_divergent_branch_00227","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"USP20 interacts with multiple proteins. One specific interaction is characterized by the fact tha... | |
medium_divergent_branch_01006 | The gene IKBKB interacts with multiple partners. One specific interaction is supported by evidence stating: 'Moreover, endogenous PKCtheta physically associates with activated IKK complexes in CD3/CD28-costimulated primary CD4(+) T cells.' Identify the disease associated with the gene described in this evidence. | schwannoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01006","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IKBKB interacts with multiple partners. One specific interaction is supported by evidence stating: 'Moreover, endogenous PKCtheta physically... | |
medium_divergent_branch_01007 | The metatarsal bone is anatomically connected to two distinct structures. One of these connections is supported by evidence stating: 'The metatarsus or metatarsal bones are a group of five long bones in the pes located between the tarsal bones of the hind- and mid-pes and the phalanges of the toes.' Based on this descr... | tarsus cartilage element | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01007","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The metatarsal bone is anatomically connected to two distinct structures. One of these connections is supported by evidence stating: 'The metatarsus ... | |
medium_divergent_branch_01008 | CAMK2A interacts with multiple proteins. One specific interaction is described by the following evidence: 'Here we show that regulated CaMKII interaction with two sites on the NMDA receptor subunit [interacting partner] provides a mechanism for the glutamate-induced translocation of the kinase to the synapse in hippoca... | Glutamate receptor ionotropic, NMDA 2B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01008","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CAMK2A interacts with multiple proteins. One specific interaction is described by the following evidence: 'Here we show that regulated CaMKII interac... | |
medium_divergent_branch_01010 | CXXC1 interacts with multiple proteins. One specific interaction is characterized by evidence that a C375A point mutation abolishes the binding of Cfp1 to Setd1 histone H3-Lys4 methyltransferase complexes, thereby abating the rescue activity of the Cfp1(361-656) fragment. Which protein, connected to CXXC1 via this spec... | Histone-lysine N-methyltransferase SETD1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01010","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXXC1 interacts with multiple proteins. One specific interaction is characterized by evidence that a C375A point mutation abolishes the binding of Cf... | |
medium_divergent_branch_01011 | MAPK8 is reported to bind multiple proteins. One specific interaction involves a putative scaffold protein that interacts with several components of the JNK signaling pathway, including mixed-lineage kinase (MLK), MAP kinase kinase MKK7, and the MAP kinase JNK itself. Which protein, encoded by the gene linked to MAPK8 ... | C-Jun-amino-terminal kinase-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01011","source_qa_id":"medium_divergent_branch_05884","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MAPK8 is reported to bind multiple proteins. One specific interaction involves a putative scaffol... | |
medium_divergent_branch_01012 | The protein NONO interacts with multiple partners. One specific interaction is supported by evidence stating that PP1 interacts directly with the RVxF motif only in p54nrb, but not in PSF. Which protein is encoded by the gene corresponding to this specific interaction partner? | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01012","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein NONO interacts with multiple partners. One specific interaction is supported by evidence stating that PP1 interacts directly with the RVx... | |
medium_divergent_branch_01013 | MBD3L1 interacts with multiple proteins. One of these interaction partners is supported by evidence showing interaction with MBD3L1 and MBD3 in vitro and in yeast two-hybrid assays. Which protein corresponds to this interaction partner? | Methyl-CpG-binding domain protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01013","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MBD3L1 interacts with multiple proteins. One of these interaction partners is supported by evidence showing interaction with MBD3L1 and MBD3 in vitro... | |
medium_divergent_branch_01014 | HAX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'A novel protein, HS-1 associated protein X-1 (HAX-1), was identified to be able to bind with a prion protein strongly.' Which protein is encoded by the gene that interacts with HAX1 in this specific context? | Major prion protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01014","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HAX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'A novel protein, HS-1 associated protein X-1 (HAX-1), was i... | |
medium_divergent_branch_01015 | MPRIP interacts with multiple proteins. One interaction is described by the statement: 'Here, we show that p116(Rip), through its C-terminal coiled-coil domain, interacts directly with the C-terminal leucine zipper of the regulatory myosin-binding subunits of myosin II phosphatase, the 85 kDa subunit and MBS130.' Which... | Protein phosphatase 1 regulatory subunit 12C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01015","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MPRIP interacts with multiple proteins. One interaction is described by the statement: 'Here, we show that p116(Rip), through its C-terminal coiled-c... | |
medium_divergent_branch_01016 | GABPA interacts with multiple genes. One such interaction is supported by evidence stating: 'In this study, a direct interaction of the C1 factor with GABP is demonstrated, defining the C1 factor as the critical coordinator of the enhancer complex assembly.' Which disease is associated with the gene identified as the C... | methylmalonic acidemia with homocystinuria, type cblX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01016","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABPA interacts with multiple genes. One such interaction is supported by evidence stating: 'In this study, a direct interaction of the C1 factor wit... | |
medium_divergent_branch_01017 | CNOT7 interacts with multiple genes. One interaction partner is described as a canonical member of a family of RNA-binding ubiquitin ligases that associates with cytoplasmic deadenylation complexes and ubiquitinates CNOT7 (also known as Caf1), the main catalytic subunit of the CCR4-NOT deadenylation machinery. Which di... | autoimmune disorder of the nervous system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01017","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNOT7 interacts with multiple genes. One interaction partner is described as a canonical member of a family of RNA-binding ubiquitin ligases that ass... | |
medium_divergent_branch_01019 | DNMT3A interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that the mouse homolog of UHRF1 interacts more strongly with regulatory domains of the de novo methyltransferases Dnmt3a and Dnmt3b.' Which disease is connected to this interaction partner through genomic alterations? | gastric cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01019","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNMT3A interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that the mouse homolog of UHRF1 interacts more... |
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