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medium_divergent_branch_01020 | PARP10 is associated with multiple molecular functions. One specific association is supported by evidence stating: 'Here, we describe the isolation of a novel 150 kDa protein, designated PARP-10, that interacts with Myc.' Based on this evidence, which molecular function is linked to PARP10, and what is the parent term ... | transcription factor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01020","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARP10 is associated with multiple molecular functions. One specific association is supported by evidence stating: 'Here, we describe the isolation o... | |
medium_divergent_branch_01022 | LAMTOR3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In a two-hybrid screen with p14 as a bait, we identified the mitogen-activated protein kinase (MAPK) scaffolding protein MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) partner 1 (MP1) as an interacting protein.' ... | polyploidy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01022","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LAMTOR3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In a two-hybrid screen with p14 as a bait, we identified... | |
medium_divergent_branch_01023 | PRKCD interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified the multifunctional chaperon protein [REDACTED] as a protein kinase C (PKC)-binding protein interacting with PKCalpha, PKCzeta, PKCdelta, and PKC mu.' Which protein, connected to PRKCD via this specific interaction ... | Complement component 1 Q subcomponent-binding protein, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01023","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCD interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified the multifunctional chaperon protein [REDACT... | |
medium_divergent_branch_01024 | GP1BA interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation studies demonstrated that Src, phosphoinositide 3-kinase (PI 3-kinase), and GPIb form a complex in GPIb-stimulated platelets.' Which disease is causally linked to the protein identified in this specific intera... | ovarian cyst | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01024","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GP1BA interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation studies demonstrated that Src, phospho... | |
medium_divergent_branch_01025 | The protein LAT interacts with multiple partners. One specific interaction is supported by evidence stating that the partner protein is co-precipitated with LAT in pervanadate-activated Jurkat cells. Which disease is associated with this specific interacting partner as a biomarker? | familial glucocorticoid deficiency | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01025","source_qa_id":"medium_divergent_branch_06010","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein LAT interacts with multiple partners. One specific interaction is supported by eviden... | |
medium_divergent_branch_01026 | COPB1 is known to interact with multiple proteins. One specific interaction was confirmed using in vitro and in vivo binding assays. Which gene product is linked to COPB1 by this specific interaction evidence? | TTYH2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01026","source_qa_id":"medium_divergent_branch_00351","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"COPB1 is known to interact with multiple proteins. One specific interaction was confirmed using i... | |
medium_divergent_branch_01027 | SOX6 is involved in multiple biological processes. One specific process associated with SOX6 is characterized by evidence stating: 'For SOX6, these processes include, but are not limited to, neurogenesis and skeletogenesis.' Which anatomical structure is the result of the development of this specific biological process... | brain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01027","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX6 is involved in multiple biological processes. One specific process associated with SOX6 is characterized by evidence stating: 'For SOX6, these p... | |
medium_divergent_branch_01028 | SMAD6 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating that the interacting partner and SMAD6 possess unique structural features compared with previously described MADs, can physically interact with each other, and, in the case of SMAD6, with other known human MA... | SMAD family member 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01028","source_qa_id":"medium_divergent_branch_04146","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SMAD6 is reported to interact with multiple proteins. One specific interaction is supported by ev... | |
medium_divergent_branch_01029 | DNTTIP1 interacts with multiple genes. One of these interactions is supported by evidence that TdIF1 binds directly to the protein encoded by the interacting gene, both in vitro and in vivo. Which protein is encoded by the gene connected to DNTTIP1 via this specific interaction? | DNA nucleotidylexotransferase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01029","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNTTIP1 interacts with multiple genes. One of these interactions is supported by evidence that TdIF1 binds directly to the protein encoded by the int... | |
medium_divergent_branch_01030 | PIN1 interacts with multiple genes. Evidence for one of these interactions states that the peptidyl-prolyl isomerase Pin1 plays a key role in the degradation of the interacting partner. Which cellular component is this specific interacting partner located in? | cytoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01030","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIN1 interacts with multiple genes. Evidence for one of these interactions states that the peptidyl-prolyl isomerase Pin1 plays a key role in the deg... | |
medium_divergent_branch_01031 | COL5A2 is associated with multiple biological processes. One association is supported by evidence stating: 'Collagen fibril diameters were increased, but fibril density was decreased throughout the stroma at all developmental stages.' Identify the biological process linked to this specific association via an 'is a' rel... | sensory organ morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01031","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COL5A2 is associated with multiple biological processes. One association is supported by evidence stating: 'Collagen fibril diameters were increased,... | |
medium_divergent_branch_01032 | ARHGEF4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here the APC gene product is shown to bind through its armadillo repeat domain to a Rac-specific guanine nucleotide exchange factor (GEF), termed Asef.' Which protein, encoded by the gene connected to ARHGEF4 via this specific ... | Ras-related C3 botulinum toxin substrate 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01032","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARHGEF4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here the APC gene product is shown to bind through its a... | |
medium_divergent_branch_01033 | The gene TIGD6 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 4.14 TPM, a z-score of 1.57, and a fold enrichment of 2.43. Identify the cell type associated with these statistics, and then determine the cell type from which it develops. | pro-NK cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01033","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TIGD6 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 4.14 TPM, a z... | |
medium_divergent_branch_01035 | The gene DBNL is known to interact with multiple proteins. One specific interaction partner is described in literature as an adapter protein (3BP2) involved in leukocyte signaling downstream of Src/Syk-kinase coupled immunoreceptors, which directly interacts with the endocytic scaffold protein CIN85 and the actin-bindi... | SH3 domain-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01035","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DBNL is known to interact with multiple proteins. One specific interaction partner is described in literature as an adapter protein (3BP2) i... | |
medium_divergent_branch_01036 | The gene ITK interacts with multiple partners via binding. One specific interaction is supported by evidence stating: 'Third, the Itk Src homology (SH3) 3 and SH2 domains interact cooperatively with Syk-phosphorylated [the interacting partner gene].' Which disease is associated with the gene identified in this specific... | immunodeficiency 81 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01036","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ITK interacts with multiple partners via binding. One specific interaction is supported by evidence stating: 'Third, the Itk Src homology (S... | |
medium_divergent_branch_01037 | The gene EIF2B2 interacts with multiple partners. One specific interaction is supported by evidence stating that removal of either the N- or C-terminal conserved domains of the epsilon subunit of eIF2B leads to a significant loss of GEF activity and reduced or abolished interaction with the alpha-, gamma-, and delta-su... | leukoencephalopathy with vanishing white matter 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01037","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF2B2 interacts with multiple partners. One specific interaction is supported by evidence stating that removal of either the N- or C-termin... | |
medium_divergent_branch_01038 | The gene FYN interacts with multiple partners. One specific interaction is supported by evidence stating: 'Furthermore, in vitro and in vivo binding studies indicate that the protein encoded by the interacting gene is capable of binding directly to FynT, an interaction mediated by the FynT SH3 domain.' Which protein is... | SH2 domain-containing protein 1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01038","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FYN interacts with multiple partners. One specific interaction is supported by evidence stating: 'Furthermore, in vitro and in vivo binding ... | |
medium_divergent_branch_01039 | CDC37 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that ERK5 interacts with the Hsp90-Cdc37 chaperone in resting cells, and that inhibition of Hsp90 or Cdc37 results in ERK5 ubiquitylation and proteasomal degradation.' Which protein, connected to CDC37 via a binding inter... | Heat shock protein HSP 90-beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01039","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDC37 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that ERK5 interacts with the Hsp90-Cdc37 chaperone... | |
medium_divergent_branch_01040 | MSH4 interacts with multiple proteins. One specific interaction is described as follows: 'here we have identified von Hippel-Lindau (VHL) tumor suppressor-binding protein 1 as an interacting protein partner for human MSH4.' Which disease is associated with this specific interacting protein? | leiomyoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01040","source_qa_id":"medium_divergent_branch_03960","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MSH4 interacts with multiple proteins. One specific interaction is described as follows: 'here we... | |
medium_divergent_branch_01041 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.551 and an adjusted p-value of 0.0422. Which protein does that selected gene encode? | Zinc finger protein 704 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01041","source_qa_id":"medium_divergent_branch_06295","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_01043 | MIR33A is associated with multiple biological processes. One association is supported by evidence stating that antagonism of miR-33a may increase bile acid synthesis to maintain lipid homeostasis and prevent nonalcoholic fatty liver disease, diabetes, and obesity. Which biological process is negatively regulated by the... | bile acid biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01043","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR33A is associated with multiple biological processes. One association is supported by evidence stating that antagonism of miR-33a may increase bil... | |
medium_divergent_branch_01044 | MYCL interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that ST binds specifically to the MYC homolog MYCL (L-MYC) and recruits it to the 15-component [protein] histone acetyltransferase and chromatin remodeling complex.' Which protein, encoded by the gene interacting with... | E1A-binding protein p400 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01044","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYCL interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that ST binds specifically to the MYC homolog ... | |
medium_divergent_branch_01045 | MAN1A2 interacts with multiple proteins. One of these interactions is characterized by the following mechanism: circMAN1A2 is regulated by PRPF40B and directly binds to the target protein, disrupting its interaction with KEAP1, thereby promoting NRF2 degradation and ferroptosis. Which protein, connected to MAN1A2 via a... | Telomerase protein component 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01045","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAN1A2 interacts with multiple proteins. One of these interactions is characterized by the following mechanism: circMAN1A2 is regulated by PRPF40B an... | |
medium_divergent_branch_01046 | USP18 interacts with multiple proteins. One specific interaction is characterized by the mechanism where USP18 binds to the partner protein, removes its ubiquitination, and subsequently stabilizes it. Which protein corresponds to this mechanistic description? | Twist-related protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01046","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP18 interacts with multiple proteins. One specific interaction is characterized by the mechanism where USP18 binds to the partner protein, removes ... | |
medium_divergent_branch_01047 | TRAF1 interacts with multiple genes. One of these interaction partners is described in evidence stating that a TNF receptor superfamily member associates with TRAF1, TRAF2, and TRAF3, and induces nuclear factor (NF)-kappaB activation via TRAF2. Which molecular function is enabled by this specific interaction partner? | tumor necrosis factor receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01047","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF1 interacts with multiple genes. One of these interaction partners is described in evidence stating that a TNF receptor superfamily member associ... | |
medium_divergent_branch_01049 | RPA1 is known to bind to multiple gene products. One of these partners has been shown to interact with replication protein A (RPA) and RPA-coated DNA, with RPA facilitating the loading of this partner onto RPA-free DNA. Which gene product does this specific partner interact with? | RECQL4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01049","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPA1 is known to bind to multiple gene products. One of these partners has been shown to interact with replication protein A (RPA) and RPA-coated DNA... | |
medium_divergent_branch_01050 | E2F1 interacts with multiple proteins. One specific interaction is supported by evidence stating that 'Both hDP-1 and hDP-2 bind to all E2F family members in vivo, and each complex is capable of activating transcription.' Which protein product is encoded by the gene corresponding to this specific interacting partner? | Transcription factor Dp-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01050","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"E2F1 interacts with multiple proteins. One specific interaction is supported by evidence stating that 'Both hDP-1 and hDP-2 bind to all E2F family me... | |
medium_divergent_branch_01051 | The facial nerve is a type of anatomy that has more than one parent class in the hierarchy. Evidence for one of these parent classes describes an entity that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the h... | cranial neural crest | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01051","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The facial nerve is a type of anatomy that has more than one parent class in the hierarchy. Evidence for one of these parent classes describes an ent... | |
medium_divergent_branch_01052 | ELK1 interacts with multiple proteins. One specific interaction involves a protein that, along with SAP1a, forms a ternary complex on the Serum Response Element (SRE) within the c-fos promoter. Which protein is this? | Serum response factor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01052","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ELK1 interacts with multiple proteins. One specific interaction involves a protein that, along with SAP1a, forms a ternary complex on the Serum Respo... | |
medium_divergent_branch_01054 | CDK5RAP2 is associated with multiple cellular components via 'located in' relationships. One association is supported by evidence stating: 'we demonstrate that CDK5RAP2 localizes to microtubules and concentrates at the distal tips in addition to centrosomal localization.' Which cellular component, connected to CDK5RAP2... | microtubule cytoskeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01054","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK5RAP2 is associated with multiple cellular components via 'located in' relationships. One association is supported by evidence stating: 'we demons... | |
medium_divergent_branch_01055 | NDEL1 interacts with multiple genes via binding. One specific interaction is supported by evidence stating that 14-3-3epsilon binds to CDK5/p35-phosphorylated NUDEL, a binding event that maintains NUDEL phosphorylation. Which gene is connected to NDEL1 through this specific binding interaction? | YWHAG | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01055","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NDEL1 interacts with multiple genes via binding. One specific interaction is supported by evidence stating that 14-3-3epsilon binds to CDK5/p35-phosp... | |
medium_divergent_branch_01056 | BIRC2 interacts with multiple proteins. One interaction is supported by evidence stating that endogenous coimmunoprecipitation experiments indicated viral infection caused the recruitment of cIAP1 and cIAP2 to the interacting partner, along with TRAF6 and VISA. What protein is encoded by this interacting partner? | TNF receptor-associated factor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01056","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIRC2 interacts with multiple proteins. One interaction is supported by evidence stating that endogenous coimmunoprecipitation experiments indicated ... | |
medium_divergent_branch_01058 | CPLX1 interacts with multiple proteins. One specific interaction is characterized by Complexin binding in an antiparallel alpha-helical conformation to the groove between the synaptobrevin and syntaxin helices. Which disease is associated with the protein involved in this specific interaction through genomic alteration... | oppositional defiant disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01058","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CPLX1 interacts with multiple proteins. One specific interaction is characterized by Complexin binding in an antiparallel alpha-helical conformation ... | |
medium_divergent_branch_01060 | The gene M6PR is associated with multiple protein partners via binding interactions. One specific interaction is supported by evidence stating: 'We have identified a 47 kDa protein (a specific binding partner) that binds selectively to the cytoplasmic domains of cation-independent and cation-dependent MPRs.' Which prot... | Perilipin-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01060","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene M6PR is associated with multiple protein partners via binding interactions. One specific interaction is supported by evidence stating: 'We h... | |
medium_divergent_branch_01061 | MIR26A1 is associated with multiple biological processes. One association is supported by evidence showing that after stimulation with IL-6, miR-26a expression was upregulated in THP-1 cells, while the supernatant level of IL-6 was downregulated by transfection of miR-26a mimics. Which biological process is negatively ... | cytokine production involved in inflammatory response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01061","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR26A1 is associated with multiple biological processes. One association is supported by evidence showing that after stimulation with IL-6, miR-26a ... | |
medium_divergent_branch_01062 | FANCD2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation with purified proteins indicates that this interaction partner interacts with FANCD2 through its C-terminal amino acid 1001-1328 fragment.' Which protein, linked to FANCD2 by this specific binding... | Fanconi anemia group I protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01062","source_qa_id":"medium_divergent_branch_00333","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FANCD2 interacts with multiple proteins. One specific interaction is supported by evidence statin... | |
medium_divergent_branch_01063 | STAM2 interacts with multiple proteins. One of these interaction partners is reported to interact with SARA and the ESCRT-0 subunits STAM2 and Eps15b, but uniquely associates with the core subunit Hrs. Which protein is encoded by the gene corresponding to this interaction partner? | RING finger protein 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01063","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STAM2 interacts with multiple proteins. One of these interaction partners is reported to interact with SARA and the ESCRT-0 subunits STAM2 and Eps15b... | |
medium_divergent_branch_01064 | NEK6 is associated with multiple biological processes. One of these associations is supported by evidence stating that 'Nek6, Nek7 and Nek9 also seem to regulate mitosis.' Which biological process, connected to the process supported by this evidence via an 'is a' relationship, is the correct answer? | regulation of cell cycle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01064","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NEK6 is associated with multiple biological processes. One of these associations is supported by evidence stating that 'Nek6, Nek7 and Nek9 also seem... | |
medium_divergent_branch_01065 | The scala media is defined as the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing). Based on this definition, which of the following anatomical categories is the scala media a subtype of? | tube | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01065","source_qa_id":"medium_divergent_branch_05806","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The scala media is defined as the division of the spiral canal of the cochlea that contains the o... | |
medium_divergent_branch_01067 | FCRL3 is associated with multiple biological processes. One association is supported by evidence that FCRL3 ligation augmented CpG oligodeoxynucleotide TLR9-mediated B-cell proliferation, activation, and survival, but surprisingly, abrogated plasma cell differentiation and antibody production. Which biological process,... | B cell activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01067","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FCRL3 is associated with multiple biological processes. One association is supported by evidence that FCRL3 ligation augmented CpG oligodeoxynucleoti... | |
medium_divergent_branch_01069 | SCUBE1 is associated with multiple biological processes. One association is supported by evidence stating that SCUBE1 and SCUBE2 define a family of secreted proteins expressed in vascular endothelium that may play important roles in development, inflammation, and thrombosis. Which biological process, connected to the p... | defense response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01069","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SCUBE1 is associated with multiple biological processes. One association is supported by evidence stating that SCUBE1 and SCUBE2 define a family of s... | |
medium_divergent_branch_01070 | ERLIN2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Whereas interaction of this gene with 14-3-3 proteins was strongly reduced upon infection with Shigella, erlin-1 and erlin-2 (erlin-1/2) specifically bound to this gene's complexes.' Which disease is associated with this g... | obesity disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01070","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERLIN2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Whereas interaction of this gene with 14-3-3 protei... | |
medium_divergent_branch_01071 | PLCG1 interacts with multiple genes. One of these interacting partners is characterized by the following evidence: 'Furthermore, upon tyrosine phosphorylation, this protein associated selectively with the SH2 domains of Abl, Lck, and the C-terminal SH2 domain of phospholipase Cgamma and insulin enhanced the association... | retinal dystrophy and obesity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01071","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLCG1 interacts with multiple genes. One of these interacting partners is characterized by the following evidence: 'Furthermore, upon tyrosine phosph... | |
medium_divergent_branch_01073 | BMP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using antibody-mediated immunofluorescence copatching of epitope-tagged receptors, we provide evidence in live cells for preexisting heteromeric (BR-II/BR-Ia and BR-II/BR-Ib) and homomeric (BR-II/BR-II, BR-Ia/ BR-Ia, BR-Ib/ BR-Ib,... | Bone morphogenetic protein receptor type-1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01073","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using antibody-mediated immunofluorescence copatching of ep... | |
medium_divergent_branch_01074 | MCUB is associated with multiple biological processes. One specific association is supported by evidence stating that MCUB incorporation into the mitochondrial calcium uniporter (mtCU) serves as a stress-responsive mechanism to limit mitochondrial calcium (mCa2+) overload during cardiac injury. Which biological process... | intracellular calcium ion homeostasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01074","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCUB is associated with multiple biological processes. One specific association is supported by evidence stating that MCUB incorporation into the mit... | |
medium_divergent_branch_01075 | TMEM165 is associated with multiple biological processes. One association is supported by evidence stating: 'We further obtained direct biochemical evidence that TMEM165 mediates Ca2+ and Mn2+ influxes.' Which biological process is a parent term (via an 'is a' relationship) of the process directly linked to TMEM165 by ... | metal ion transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01075","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TMEM165 is associated with multiple biological processes. One association is supported by evidence stating: 'We further obtained direct biochemical e... | |
medium_divergent_branch_01076 | The protein TNP1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'More definitive information on their roles in spermiogenesis has recently been obtained using mice with null mutations in the Tnp1 or Tnp2 genes for TP1 and TP2, respectively.' Identify the bio... | germ cell development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01076","source_qa_id":"medium_divergent_branch_03087","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein TNP1 is associated with multiple biological processes. One specific association is su... | |
medium_divergent_branch_01077 | RAB7A interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show that membrane recruitment of retromer is mediated by bivalent recognition of an effector of PI3K, this protein, and the RAB7A GTPase, by the VPS35 retromer subunit.' What is the name of the protein encoded by thi... | Sorting nexin-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01077","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB7A interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show that membrane recruitment of retromer is ... | |
medium_divergent_branch_01080 | Histamine production involved in the inflammatory response is enabled by more than one cell type. One of these cells is described as a fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm containing coarse ... | band form basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01080","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Histamine production involved in the inflammatory response is enabled by more than one cell type. One of these cells is described as a fully differen... | |
medium_divergent_branch_01081 | AMOTL1 interacts with multiple genes. One of these interacting partners is reported to physically interact with AMOTL1 and enhance its stability via lysine 63-linked ubiquitination. Which cellular component is this specific interacting partner located in? | mitotic spindle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01081","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMOTL1 interacts with multiple genes. One of these interacting partners is reported to physically interact with AMOTL1 and enhance its stability via ... | |
medium_divergent_branch_01082 | RIG-I (DDX58) interacts with multiple genes. One of these interacting partners is described by the following evidence: 'We further show that there is no interaction between this protein and RIG-I-like receptors (RLRs) in unstimulated or uninfected cells, but upon viral infection or ligand stimulation, this protein bind... | chromatin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01082","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RIG-I (DDX58) interacts with multiple genes. One of these interacting partners is described by the following evidence: 'We further show that there is... | |
medium_divergent_branch_01083 | C-reactive protein (CRP) is associated with multiple biological processes. One specific association is supported by evidence showing that CRP-bound E-LDL failed to transform macrophages into foam cells, indicating an inhibitory effect on this differentiation pathway. Which biological process, connected to the process d... | macrophage derived foam cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01083","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"C-reactive protein (CRP) is associated with multiple biological processes. One specific association is supported by evidence showing that CRP-bound E... | |
medium_divergent_branch_01084 | IKBKB interacts with multiple genes. One interaction is supported by evidence stating: 'In the presence of antisense mRNA to SIMPL, the physical association between a serine/threonine-protein kinase and IKKbeta but not a serine/threonine-protein kinase and IKKalpha is greatly diminished.' Which disease is associated wi... | coronary artery disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01084","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IKBKB interacts with multiple genes. One interaction is supported by evidence stating: 'In the presence of antisense mRNA to SIMPL, the physical asso... | |
medium_divergent_branch_01085 | RBP4 interacts with multiple proteins. One interaction is supported by evidence stating: 'At physiological ionic strength apo and holo retinol-binding protein form 1:1 molar complexes with prealbumin.' Which protein, encoded by the gene involved in this specific interaction, is the binding partner of RBP4? | Transthyretin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01085","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBP4 interacts with multiple proteins. One interaction is supported by evidence stating: 'At physiological ionic strength apo and holo retinol-bindin... | |
medium_divergent_branch_01086 | MMS22L interacts with multiple genes. One of these interaction partners is described as a strand exchange protein that directly interacts with the MMS22L subunit. Which disease is associated with this specific gene via a biomarker relationship? | uveal melanoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01086","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MMS22L interacts with multiple genes. One of these interaction partners is described as a strand exchange protein that directly interacts with the MM... | |
medium_divergent_branch_01087 | GSTP1 is associated with multiple biological processes. One association is supported by evidence stating that GSTP1 prevented LPS-induced TNF-alpha, IL-1beta, MCP-1, and NO production. Which biological process, connected to GSTP1 via 'involved in', is linked to the final answer through the relation 'negatively regulate... | tumor necrosis factor production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01087","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GSTP1 is associated with multiple biological processes. One association is supported by evidence stating that GSTP1 prevented LPS-induced TNF-alpha, ... | |
medium_divergent_branch_01088 | Skeletal muscle fiber differentiation is a subtype of two distinct biological processes. One of these processes is defined by the following evidence: 'The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myo... | cell of skeletal muscle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01088","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Skeletal muscle fiber differentiation is a subtype of two distinct biological processes. One of these processes is defined by the following evidence:... | |
medium_divergent_branch_01089 | PLCB3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Immunoprecipitation studies revealed that the interaction partner interacts specifically with PLC-beta3, but not with other PLC-beta isotypes.' What is the name of the protein encoded by this interaction partner? | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01089","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLCB3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Immunoprecipitation studies revealed that the int... | |
medium_divergent_branch_01090 | RABAC1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'A selective interaction between α-synuclein and PRA1 was confirmed by coimmunoprecipitation and GST pull-down assays.' Which protein is encoded by the gene that interacts with RABAC1 and is associated with this specific e... | Alpha-synuclein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01090","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RABAC1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'A selective interaction between α-synuclein and PR... | |
medium_divergent_branch_01091 | OTUB1 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'We further show that this protein preferentially binds to the monoubiquitinated OTUB1 via Ub interaction with its backside donor Ub-interacting surface, suggesting that this binding interferes with the self-a... | extracellular exosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01091","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OTUB1 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'We further show that this protein pre... | |
medium_divergent_branch_01092 | GTF3C2 interacts with multiple genes. One interaction is supported by evidence describing novel interactions of hTFIIIC63 with hTFIIIC102, hTFIIIB90, and hRPC62, as well as hTFIIIC102-hTFIIIB90 and hTFIIIB90-hRPC39 interactions that parallel yeast findings. Which disease is associated with the gene identified by this e... | neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01092","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GTF3C2 interacts with multiple genes. One interaction is supported by evidence describing novel interactions of hTFIIIC63 with hTFIIIC102, hTFIIIB90,... | |
medium_divergent_branch_01094 | SREBF1 interacts with multiple genes. One such interaction is supported by evidence stating: 'Here we show that this activator-recruited cofactor (ARC) interacts directly with several different activators, including SREBP-1a, VP16 and the p65 subunit of NF-kappaB, and strongly enhances transcription directed by these a... | Mediator of RNA polymerase II transcription subunit 24 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01094","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SREBF1 interacts with multiple genes. One such interaction is supported by evidence stating: 'Here we show that this activator-recruited cofactor (AR... | |
medium_divergent_branch_01095 | HIST3H3 interacts with multiple proteins. One of these interaction partners is characterized by crystal structures showing that its apo-form and its complex with five different trimethyllysine histone peptides reveal binding via the top face of its β-propeller architecture. Which protein is encoded by the gene correspo... | Polycomb protein EED | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01095","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIST3H3 interacts with multiple proteins. One of these interaction partners is characterized by crystal structures showing that its apo-form and its ... | |
medium_divergent_branch_01096 | SENP1 interacts with multiple proteins. One of these interactions is characterized by the following mechanism: phosphorylation facilitates the binding between the partner protein and the desumoylating enzyme SENP1, leading to the partner's desumoylation and activation. Which protein, connected to SENP1 via this specifi... | Chorion-specific transcription factor GCMa | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01096","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SENP1 interacts with multiple proteins. One of these interactions is characterized by the following mechanism: phosphorylation facilitates the bindin... | |
medium_divergent_branch_01097 | NRP1 interacts with multiple proteins. One interaction is supported by evidence stating that Anti-Myc antibodies immunoprecipitated 125I-VEGF165 and 125I-PlGF-2 in the presence of the b1b2 domain, but not in the presence of the a1a2 and c domains. Which protein product is encoded by the gene corresponding to this speci... | Vascular endothelial growth factor A, long form | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01097","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NRP1 interacts with multiple proteins. One interaction is supported by evidence stating that Anti-Myc antibodies immunoprecipitated 125I-VEGF165 and ... | |
medium_divergent_branch_01099 | The intervertebral disk of the sacral vertebra is a type of anatomy that connects to a broader anatomical structure via a 'part of' relationship. Evidence for this connection describes the entity as being part of the sacral region of the vertebral column and notes that it connects at least one sacral vertebra to anothe... | pelvic region of trunk | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01099","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The intervertebral disk of the sacral vertebra is a type of anatomy that connects to a broader anatomical structure via a 'part of' relationship. Evi... | |
medium_divergent_branch_01101 | The androgen receptor (AR) interacts with multiple proteins. One specific interaction is described as follows: 'Here, we demonstrate that a specific protein-protein interaction occurs between the gene product of CTNNB1 and AR.' Which disease is therapeutically linked to the gene encoding this interacting protein? | drug-induced hepatitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01101","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The androgen receptor (AR) interacts with multiple proteins. One specific interaction is described as follows: 'Here, we demonstrate that a specific ... | |
medium_divergent_branch_01102 | KPNA6 interacts with multiple proteins. One interaction is supported by evidence stating: 'Binding affinity studies showed that all importin alpha proteins from humans or Xenopus bind their import receptor (importin beta) and their export receptor (CAS) with only marginal differences.' Which protein product is encoded ... | Importin subunit beta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01102","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KPNA6 interacts with multiple proteins. One interaction is supported by evidence stating: 'Binding affinity studies showed that all importin alpha pr... | |
medium_divergent_branch_01104 | LTK interacts with multiple genes. One interaction is supported by evidence stating: 'Western blot analysis revealed that the wild-type LTK protein was tyrosine-phosphorylated in vivo and associated with SH2 containing proteins, PLC-gamma 1, p85 subunit of PI3-K and GAP, in vivo.' Which disease is connected to the gene... | bipolar disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01104","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LTK interacts with multiple genes. One interaction is supported by evidence stating: 'Western blot analysis revealed that the wild-type LTK protein w... | |
medium_divergent_branch_01105 | KAT6B interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Through its C-terminal SM (serine- and methionine-rich) domain, MORF binds to this partner in vitro and in vivo.' Which protein product is encoded by the gene corresponding to this interaction partner? | Runt-related transcription factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01105","source_qa_id":"medium_divergent_branch_00776","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"KAT6B interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_01106 | RSAD2 (viperin) interacts with multiple proteins. One interaction partner is described as a cytosolic Fe/S protein assembly factor that interacts with wild-type viperin, which requires ER localization for full antiviral activity. Which protein is encoded by the gene corresponding to this interaction partner? | Probable cytosolic iron-sulfur protein assembly protein CIAO1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01106","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RSAD2 (viperin) interacts with multiple proteins. One interaction partner is described as a cytosolic Fe/S protein assembly factor that interacts wit... | |
medium_divergent_branch_01108 | FGF2 is associated with multiple biological processes. One specific association is supported by evidence stating that PI3K activity is required for FGF-2-induced PLCgamma1 activation and that the PI3K/PLCgamma1 pathway is involved in FGF-2-dependent cell migration, as determined using a Transwell assay. Which biologica... | blood vessel endothelial cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01108","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF2 is associated with multiple biological processes. One specific association is supported by evidence stating that PI3K activity is required for F... | |
medium_divergent_branch_01109 | CDAN1 interacts with multiple proteins. One interaction is supported by evidence that Codanin-1 is part of a cytosolic Asf1-H3.1-H4-Importin-4 complex and binds directly to Asf1 via a conserved B-domain, implying a mutually exclusive interaction with the chaperones CAF-1 and HIRA. Which protein, connected to CDAN1 thro... | Histone chaperone ASF1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01109","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDAN1 interacts with multiple proteins. One interaction is supported by evidence that Codanin-1 is part of a cytosolic Asf1-H3.1-H4-Importin-4 comple... | |
medium_divergent_branch_01110 | EYA2 interacts with multiple proteins. One interaction partner is described as binding to and stabilizing the co-transcriptional regulator EYA2, a process that stimulates mesenchymal gene expression and suppresses IFNα/β, chemokines CXCL9/10, and antigen presentation machinery, driven by the AXL extracellular ligand GA... | F-box only protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01110","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EYA2 interacts with multiple proteins. One interaction partner is described as binding to and stabilizing the co-transcriptional regulator EYA2, a pr... | |
medium_divergent_branch_01112 | CUL1 interacts with multiple proteins. One interaction is characterized by the following evidence: 'In an asynchronous population of dividing cells, a minor amount of CUL1 specifically associates with cyclin A but not with other cyclins or CDK inhibitors.' Which protein is encoded by the gene corresponding to this inte... | Cyclin-A1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01112","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL1 interacts with multiple proteins. One interaction is characterized by the following evidence: 'In an asynchronous population of dividing cells, ... | |
medium_divergent_branch_01113 | Type II interferon production is enabled by multiple cell types. One such cell is described as a mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses. Which cell type does this specific NK T cell develop from? | activated CD4-positive type I NK T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01113","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Type II interferon production is enabled by multiple cell types. One such cell is described as a mature NK T cell that secretes interferon-gamma and ... | |
medium_divergent_branch_01114 | TRAF3 interacts with multiple genes. One of these interaction partners is identified in a coimmunoprecipitation experiment where either TNF receptor-associated factor-2 (TRAF2) or the partner molecule binds to the partner molecule. Which disease is associated with this specific interaction partner as a biomarker? | Hodgkins lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01114","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF3 interacts with multiple genes. One of these interaction partners is identified in a coimmunoprecipitation experiment where either TNF receptor-... | |
medium_divergent_branch_01115 | ABCB7 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Furthermore, in vitro and in vivo pull-down assays revealed that ABC7 protein is interacted with the carboxy-terminal region containing the iron-sulfur cluster of the enzyme encoded by the interacting gene.' Which disease ... | protoporphyria, erythropoietic, 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01115","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCB7 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Furthermore, in vitro and in vivo pull-down assays ... | |
medium_divergent_branch_01116 | DDX3X is associated with multiple biological processes. One association is supported by evidence that DDX3 regulates MTP gene expression and the process in question through interplay with HNF4 and SHP. Which broader biological process is the parent of this specific process in the Gene Ontology hierarchy? | chemical homeostasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01116","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX3X is associated with multiple biological processes. One association is supported by evidence that DDX3 regulates MTP gene expression and the proc... | |
medium_divergent_branch_01117 | The gene SH2D1B interacts with multiple other genes. One of these interaction partners is described by evidence stating that the protein EAT-2 binds to phosphorylated receptors CD84, a specific SLAM family member, CD229, and CD244, acting as a natural inhibitor that interferes with the recruitment of the tyrosine phosp... | Signaling lymphocytic activation molecule | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01117","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SH2D1B interacts with multiple other genes. One of these interaction partners is described by evidence stating that the protein EAT-2 binds ... | |
medium_divergent_branch_01120 | EPHB1 interacts with multiple proteins. One specific interaction was identified using a yeast two-hybrid screen where the interacting partner served as the 'bait' to bind the cytoplasmic domain of EPHB1. Which disease is associated with genomic alterations in this specific interacting partner? | carcinoma of esophagus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01120","source_qa_id":"medium_divergent_branch_01143","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"EPHB1 interacts with multiple proteins. One specific interaction was identified using a yeast two... | |
medium_divergent_branch_01121 | STK38 interacts with multiple proteins. One of these interaction partners is involved in a mechanism where a translated polypeptide (CAPG-171aa) promotes tumor growth by disrupting the binding of STK38 to this partner, thereby preventing MEKK2 ubiquitination and proteasomal degradation. Which protein, connected to STK3... | E3 ubiquitin-protein ligase SMURF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01121","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STK38 interacts with multiple proteins. One of these interaction partners is involved in a mechanism where a translated polypeptide (CAPG-171aa) prom... | |
medium_divergent_branch_01122 | IPCEF1 interacts with multiple genes. One of these interacting partners is noted to also interact with other members of the cytohesin family of ARF GEFs, suggesting that this interaction is highly conserved within that family. Which protein is encoded by this specific interacting gene? | Cytohesin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01122","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IPCEF1 interacts with multiple genes. One of these interacting partners is noted to also interact with other members of the cytohesin family of ARF G... | |
medium_divergent_branch_01123 | The biological process 'positive regulation of erythrocyte clearance' is defined as any process that activates or increases the frequency, rate, or extent of erythrocyte clearance. This process is a subtype of a broader biological process. Which biological process is positively regulated by that broader process? | immune system process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01123","source_qa_id":"medium_divergent_branch_05085","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'positive regulation of erythrocyte clearance' is defined as any process t... | |
medium_divergent_branch_01125 | The ANKH protein enables multiple molecular functions. One specific function is supported by evidence stating: 'We now report that in cultured cells ANKH exports ATP, rather than PPi, and, unexpectedly, also citrate as a prominent metabolite.' Which biological process is connected to this specific molecular function th... | ATP transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01125","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The ANKH protein enables multiple molecular functions. One specific function is supported by evidence stating: 'We now report that in cultured cells ... | |
medium_divergent_branch_01126 | TAF6 interacts with multiple genes. One interaction is supported by evidence stating: 'Finally, because TAF6delta regulates certain target genes of a specific tumor suppressor protein, we tested and demonstrated a physical and functional interaction between TAF6delta and this protein.' Which protein is encoded by the g... | Cellular tumor antigen p53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01126","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAF6 interacts with multiple genes. One interaction is supported by evidence stating: 'Finally, because TAF6delta regulates certain target genes of a... | |
medium_divergent_branch_01127 | Beclomethasone dipropionate interacts with multiple drugs. One of these interacting drugs is the subject of a study investigating the efficacy and safety of its sulfate form, when combined with beclomethasone dipropionate, for the treatment of pediatric bronchial asthma. Which disease is this specific interacting drug ... | chronic bronchitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01127","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Beclomethasone dipropionate interacts with multiple drugs. One of these interacting drugs is the subject of a study investigating the efficacy and sa... | |
medium_divergent_branch_01128 | FLT4 is associated with multiple biological processes. One association is supported by evidence stating: 'In vitro and in vivo proliferation assays showed lower proliferative activity of dn-SAS cells.' Which biological process, connected to FLT4 via this specific evidence, is linked to another process through a 'positi... | cell population proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01128","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FLT4 is associated with multiple biological processes. One association is supported by evidence stating: 'In vitro and in vivo proliferation assays s... | |
medium_divergent_branch_01129 | CABIN1 interacts with multiple genes. One of these interacting partners was shown to bind to the 501-900-amino acid region of CABIN1, a region distinct from CABIN1's histone deacetylase-recruiting domain. Which cell type is enriched for the gene that exhibits this specific binding interaction with CABIN1? | natural killer cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01129","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CABIN1 interacts with multiple genes. One of these interacting partners was shown to bind to the 501-900-amino acid region of CABIN1, a region distin... | |
medium_divergent_branch_01130 | The gene DGKD is enriched in multiple cell types. One specific cell type shows a mean expression of 5.85 TPM, a z-score of 1.74, and a fold enrichment of 2.66 for DGKD. Which broader cell lineage category is this specific cell type a subtype of? | mature B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01130","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DGKD is enriched in multiple cell types. One specific cell type shows a mean expression of 5.85 TPM, a z-score of 1.74, and a fold enrichmen... | |
medium_divergent_branch_01131 | CD33 is associated with multiple biological processes. One association is supported by evidence stating: 'These data indicate that by controlling monocyte activation, CD33 is a key molecule in the inflammatory response, depending on the sialic acid microenvironment for its repressor activity.' Which broader biological ... | negative regulation of leukocyte activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01131","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD33 is associated with multiple biological processes. One association is supported by evidence stating: 'These data indicate that by controlling mon... | |
medium_divergent_branch_01132 | SH3KBP1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'A direct interaction of a phosphatase and PAK2 with CIN85 SH3 domains was confirmed by Far Western blotting.' Which disease is associated with the gene identified by this evidence through genomic alterations? | muscular dystrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01132","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SH3KBP1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'A direct interaction of a phosphatase and PAK2 wi... | |
medium_divergent_branch_01133 | CASP8 interacts with multiple proteins. One interaction partner is described as being structurally similar to Mch4 and Mch5 but lacking caspase activity, while specifically interacting with FADD, Mch4, and Mch5. Which protein, connected to CASP8 via a binding interaction, is encoded by the gene in question? | CASP8 and FADD-like apoptosis regulator | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01133","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CASP8 interacts with multiple proteins. One interaction partner is described as being structurally similar to Mch4 and Mch5 but lacking caspase activ... | |
medium_divergent_branch_01134 | TSSK2 interacts with multiple proteins. One specific interaction is supported by evidence showing that Human TSSK2 and the target protein interacted in a yeast two-hybrid system and co-immunoprecipitated after in vitro translation. Which protein corresponds to this interaction partner? | Testis-specific serine kinase substrate | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01134","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TSSK2 interacts with multiple proteins. One specific interaction is supported by evidence showing that Human TSSK2 and the target protein interacted ... | |
medium_divergent_branch_01135 | The humerus cartilage element is a subclass of two distinct anatomical entities. One of these entities is described in the evidence as being composed primarily of cartilage tissue. Which anatomical structure is the parent of the humerus cartilage element that fits this description, and what larger structure is that par... | forelimb stylopod | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01135","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The humerus cartilage element is a subclass of two distinct anatomical entities. One of these entities is described in the evidence as being composed... | |
medium_divergent_branch_01136 | CTBP1 interacts with multiple proteins. One interaction involves a partner that is part of a nuclear protein complex containing enzymatic constituents such as histone deacetylases (specifically HDAC1/2), histone methyl transferases (G9a and GLP), and the lysine-specific demethylase (LSD1). Which protein, connected to C... | Histone deacetylase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01136","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CTBP1 interacts with multiple proteins. One interaction involves a partner that is part of a nuclear protein complex containing enzymatic constituent... | |
medium_divergent_branch_01138 | The gene EVA1C is enriched in multiple immune cell types. One specific cell type shows a mean expression of 7.54 TPM, a z-score of 1.53, and a fold enrichment of 3.44 for this gene. Which cell type is this, and what is its immediate parent category in the cell type hierarchy (i.e., what cell type is it a subtype of)? | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01138","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EVA1C is enriched in multiple immune cell types. One specific cell type shows a mean expression of 7.54 TPM, a z-score of 1.53, and a fold e... | |
medium_divergent_branch_01139 | IGF1R interacts with multiple proteins. One specific interaction was characterized using the yeast two-hybrid system to compare the binding of the insulin-like growth factor-I receptor (IGF-IR) and the insulin receptor (IR) with their known substrates, p52Shc and a specific insulin receptor substrate. Which disease is ... | colon carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01139","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGF1R interacts with multiple proteins. One specific interaction was characterized using the yeast two-hybrid system to compare the binding of the in... | |
medium_divergent_branch_01140 | GABARAP interacts with multiple proteins. One of these interaction partners is characterized by the presence of a C-terminal LC3-interacting region (LIR) motif, which is essential for its efficient binding to and cleavage of LC3 and GABARAP proteins. Which cellular component is this specific interaction partner located... | autophagosome membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01140","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABARAP interacts with multiple proteins. One of these interaction partners is characterized by the presence of a C-terminal LC3-interacting region (... | |
medium_divergent_branch_01141 | PROX1 is associated with multiple biological processes. One specific association is supported by evidence stating that Prox-1 acts as a cell proliferation inducer and a fate determination factor for LECs (lymphatic endothelial cells). Which cell type is the result of the biological process linked to this specific evide... | endothelial cell of lymphatic vessel | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01141","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PROX1 is associated with multiple biological processes. One specific association is supported by evidence stating that Prox-1 acts as a cell prolifer... |
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