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medium_divergent_branch_01142 | Creatine kinase B (CKB) interacts with multiple proteins. One specific interaction is characterized by the following mechanism: the ankyrin repeat domains of the interacting partner associate with the substrate binding site of uMtCK in a SOCS box-independent manner. Which protein is encoded by the gene corresponding to... | Ankyrin repeat and SOCS box protein 9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01142","source_qa_id":"medium_divergent_branch_07324","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Creatine kinase B (CKB) interacts with multiple proteins. One specific interaction is characteriz... | |
medium_divergent_branch_01143 | CNKSR1 interacts with multiple genes. One interaction is supported by evidence stating: 'Finally, hCNK1 associates with Rhophilin and RalGDS, Rho and Ras effector molecules, respectively, suggesting that it acts as a scaffold protein to mediate cross talk between the two pathways.' Which gene, connected to CNKSR1 via a... | GOLGA2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01143","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNKSR1 interacts with multiple genes. One interaction is supported by evidence stating: 'Finally, hCNK1 associates with Rhophilin and RalGDS, Rho and... | |
medium_divergent_branch_01144 | FBXO2 interacts with multiple genes. One interaction is supported by evidence stating that Pre-integrin beta 1 is a target of Fbx2 and that these two proteins interact in the cytosol following proteasome inhibition. Which cell type is enriched for the gene identified by this specific evidence? | regulatory T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01144","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO2 interacts with multiple genes. One interaction is supported by evidence stating that Pre-integrin beta 1 is a target of Fbx2 and that these two... | |
medium_divergent_branch_01145 | ALDH7A1 is associated with multiple cellular components via 'located in' relationships. One specific evidence record indicates that the ALDH7A1 protein was found in the cytosol, nucleus, and mitochondria. Based on this evidence, which cellular component is connected to the identified location through a 'part of' relati... | cytoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01145","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ALDH7A1 is associated with multiple cellular components via 'located in' relationships. One specific evidence record indicates that the ALDH7A1 prote... | |
medium_divergent_branch_01146 | The serotonin 2C receptor (HTR2C) interacts with multiple proteins. One specific interaction is described by the statement: 'Here we report that the C terminus of the 5-hydroxytryptamine type 2C (5-HT(2C)) receptor selectively interacts with the 10th PDZ domain of a specific scaffolding protein.' Which protein is encod... | Multiple PDZ domain protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01146","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The serotonin 2C receptor (HTR2C) interacts with multiple proteins. One specific interaction is described by the statement: 'Here we report that the ... | |
medium_divergent_branch_01147 | GATA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Direct interaction of the protein encoded by the gene associated with this specific interaction evidence was observed in vivo and in vitro with the GATA1 or -2 zinc-finger transcription factors, as well as with the basic helix-lo... | Rhombotin-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01147","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Direct interaction of the protein encoded by the gene asso... | |
medium_divergent_branch_01148 | BOP1 interacts with multiple proteins. One interaction is supported by evidence stating that mutant M1 and M5 proteins, associated with large pre-ribosomal complexes, co-immunoprecipitated the interacting partner and WDR12, indicating their proper incorporation into the PeBoW complex. Which protein is this interacting ... | Pescadillo homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01148","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BOP1 interacts with multiple proteins. One interaction is supported by evidence stating that mutant M1 and M5 proteins, associated with large pre-rib... | |
medium_divergent_branch_01149 | MAPK3 interacts with multiple proteins. One interaction partner is described in evidence stating: 'We found that this protein phosphorylates Ser343 of ERK1c, thereby allowing the binding of phosphorylated ERK1c to a complex that consists of PI4KIIIβ (also known as PI4KB) and the 14-3-3γ dimer (encoded by YWHAB).' What ... | Cyclin-dependent kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01149","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK3 interacts with multiple proteins. One interaction partner is described in evidence stating: 'We found that this protein phosphorylates Ser343 o... | |
medium_divergent_branch_01150 | BCL2L1 (Bcl-xL) interacts with multiple proteins. One specific interaction was identified using Fluorescence resonance energy transfer (FRET) imaging in HeLa cells, which showed that Bcl-xL physically binds with Parkin to form cytoplasmic oligomers and also directly interacts with a specific partner on mitochondria. Wh... | Ischemic stroke | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01150","source_qa_id":"medium_divergent_branch_05551","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BCL2L1 (Bcl-xL) interacts with multiple proteins. One specific interaction was identified using F... | |
medium_divergent_branch_01151 | Human polyomavirus 1 is reported to downregulate multiple genes. One specific interaction is supported by evidence showing a log2 fold change of -1.256 and an adjusted p-value of 0.04692. Which protein is encoded by the gene that is downregulated in this specific interaction? | Glioma pathogenesis-related protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01151","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human polyomavirus 1 is reported to downregulate multiple genes. One specific interaction is supported by evidence showing a log2 fold change of -1.2... | |
medium_divergent_branch_01152 | NFKB1 interacts with multiple proteins. One interaction is supported by evidence stating that the expressed IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65. Which protein is encoded by the gene corresponding to this interacting partner? | NF-kappa-B inhibitor zeta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01152","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFKB1 interacts with multiple proteins. One interaction is supported by evidence stating that the expressed IkappaB-zeta preferentially associates wi... | |
medium_divergent_branch_01153 | ARPC1A is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'The Arp2/3 complex consists of seven evolutionarily conserved subunits (Arp2, Arp3 and ARPC1-5) and plays an essential role in generating branched actin filament networks during m... | cytoskeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01153","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARPC1A is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'The Arp2... | |
medium_divergent_branch_01154 | EIF4G1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we report that a kinase is associated with the eIF4F complex via its interaction with the C-terminal region of eIF4G.' Which disease is connected to the gene identified in this evidence through a biomarker relationshi... | medulloblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01154","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF4G1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we report that a kinase is associated with the... | |
medium_divergent_branch_01156 | SSRP1 interacts with multiple genes. One of these interacting partners is reported to form a stable, approximately 600-kDa complex with FACT in the interphase nuclei. Which cellular component is this specific interacting partner located in? | centrosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01156","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SSRP1 interacts with multiple genes. One of these interacting partners is reported to form a stable, approximately 600-kDa complex with FACT in the i... | |
medium_divergent_branch_01157 | Human polyomavirus 2 upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.012 and an adjusted p-value of 0.0339. Which disease has a genomic-alteration link with that selected gene? | myelomeningocele | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01157","source_qa_id":"medium_divergent_branch_04861","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human polyomavirus 2 upregulates several genes. In the recorded experiment, one branch showed ... | |
medium_divergent_branch_01159 | GBP7 is associated with multiple biological processes. One association is supported by evidence that GBP7 knockout inhibits Influenza A virus (IAV) replication by enhancing the expression of IAV-induced type I interferon (IFN). Which biological process, connected to the process supported by this knockout evidence, is l... | type I interferon production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01159","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GBP7 is associated with multiple biological processes. One association is supported by evidence that GBP7 knockout inhibits Influenza A virus (IAV) r... | |
medium_divergent_branch_01160 | MIR155 is associated with multiple biological processes. One association is supported by evidence stating: 'Luciferase reporter assays revealed that TAB2 was a target gene of miR-155, which was confirmed by Western blotting.' Identify the biological process linked to this specific association via the 'negatively regula... | gene expression | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01160","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR155 is associated with multiple biological processes. One association is supported by evidence stating: 'Luciferase reporter assays revealed that ... | |
medium_divergent_branch_01161 | PDPK1 interacts with multiple genes. One of these interacting partners is described as directly binding PDK1 via a consensus degron in a CK1/GSK3β-mediated phosphorylation-dependent manner. Which disease is associated with this specific interacting gene as a biomarker? | clear cell renal carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01161","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDPK1 interacts with multiple genes. One of these interacting partners is described as directly binding PDK1 via a consensus degron in a CK1/GSK3β-me... | |
medium_divergent_branch_01162 | Cholecystokinin (CCK) interacts with multiple gene products. One interaction is supported by evidence stating that probes bound to type B CCK receptors in a saturable and specific manner and acted as full agonists. Which disease is associated with the gene product described by this evidence? | gastric adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01162","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cholecystokinin (CCK) interacts with multiple gene products. One interaction is supported by evidence stating that probes bound to type B CCK recepto... | |
medium_divergent_branch_01163 | Meprobamate interacts with multiple drugs. One of these interacting partners is known to increase the elimination half-life of pentobarbitone and tolbutamide in humans upon acute administration. Which disease is this specific interacting drug indicated for? | trigeminal neuralgia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01163","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Meprobamate interacts with multiple drugs. One of these interacting partners is known to increase the elimination half-life of pentobarbitone and tol... | |
medium_divergent_branch_01164 | The gene PUS7 is associated with multiple biological processes. One association is supported by evidence stating: 'Remarkably, dysregulation of this posttranscriptional regulatory circuitry impairs hematopoietic stem cell commitment and is common to aggressive subtypes of human myelodysplastic syndromes.' Identify the ... | hematopoietic stem cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01164","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PUS7 is associated with multiple biological processes. One association is supported by evidence stating: 'Remarkably, dysregulation of this ... | |
medium_divergent_branch_01165 | ACER2 is associated with multiple biological processes. One association is supported by evidence stating: 'However, overexpression of ACER2 but not ACER2DeltaN13 or ACER2DeltaN36 inhibited the glycosylation of integrin beta1 subunit and Lamp1, suggesting that its mistargeting abolishes the ability of ACER2 to regulatio... | glycoprotein biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01165","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACER2 is associated with multiple biological processes. One association is supported by evidence stating: 'However, overexpression of ACER2 but not A... | |
medium_divergent_branch_01166 | BCL2L10 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Using a variety of approaches, including immunoaffinity and mass spectrometry, we identified a protein, [Gene A], that specifically interacts with BCLb, and not with other anti-apoptotic BCL2-like proteins.' Which disease... | nervous system disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01166","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL2L10 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Using a variety of approaches, including immunoaff... | |
medium_divergent_branch_01167 | MAPRE1 is associated with multiple biological processes. One association is supported by evidence that a short polypeptide motif, Ser-x-Ile-Pro (SxIP), is used by numerous +TIPs, including the tumor suppressor APC, the transmembrane protein STIM1, and the kinesin MCAK, for localization to microtubule tips in an EB1-dep... | protein localization to microtubule cytoskeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01167","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPRE1 is associated with multiple biological processes. One association is supported by evidence that a short polypeptide motif, Ser-x-Ile-Pro (SxIP... | |
medium_divergent_branch_01168 | GLI1 interacts with multiple proteins. One specific interaction partner is supported by evidence stating: 'The interaction was validated by reciprocal pulldowns using epitope-tagged proteins in HEK293T cells as well as by co-immunoprecipitations of the endogenous proteins in a medulloblastoma cell line.' Which disease ... | hypogonadotropic hypogonadism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01168","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GLI1 interacts with multiple proteins. One specific interaction partner is supported by evidence stating: 'The interaction was validated by reciproca... | |
medium_divergent_branch_01169 | FZR1 interacts with multiple genes. One of these interacting partners contains a KEN box sequence in its C-terminal region, which is required for its mitotic degradation and for its interaction with Cdh1. Which disease is associated with this specific interacting gene through genomic alterations? | Richter syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01169","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FZR1 interacts with multiple genes. One of these interacting partners contains a KEN box sequence in its C-terminal region, which is required for its... | |
medium_divergent_branch_01170 | Myeloid dendritic cell differentiation is enabled by more than one cell type. Evidence for one of these enabling cells describes a progenitor capable of giving rise to plasmacytoid and myeloid dendritic cells, as well as monocytes and macrophages. Which cell type, connected to this enabling cell via a 'develops from' r... | granulocyte monocyte progenitor cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01170","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Myeloid dendritic cell differentiation is enabled by more than one cell type. Evidence for one of these enabling cells describes a progenitor capable... | |
medium_divergent_branch_01171 | The gene DERL1 is associated with multiple protein partners via physical binding interactions. One specific interaction is supported by evidence stating: 'Our data on the structural arrangement of these ERAD proteins suggest that a specific ATPase interacts directly with membrane-resident components of the complex incl... | Transitional endoplasmic reticulum ATPase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01171","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DERL1 is associated with multiple protein partners via physical binding interactions. One specific interaction is supported by evidence stat... | |
medium_divergent_branch_01172 | HBP1 interacts with multiple proteins. One of these interaction partners cooperates with RanBP9 to ubiquitinate HBP1 in vitro, a process in which GID4 is dispensable. Which protein is encoded by the gene corresponding to this specific interaction partner? | WD repeat-containing protein 26 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01172","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HBP1 interacts with multiple proteins. One of these interaction partners cooperates with RanBP9 to ubiquitinate HBP1 in vitro, a process in which GID... | |
medium_divergent_branch_01173 | TRIM33 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Finally, we demonstrate that TIF1alpha interacts with TIF1gamma and the coiled-coil region of TIF1gamma is necessary for this interaction.' Identify the disease associated with the gene described in this evidence via a bi... | hepatocellular carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01173","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM33 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Finally, we demonstrate that TIF1alpha interacts w... | |
medium_divergent_branch_01174 | IGFBP3 interacts with multiple proteins. One interaction is supported by evidence showing that in basal-like TNBC cell lines (HCC1806 and MDA-MB-468), treatment with 20 µM etoposide induces the formation of complexes between IGFBP-3 and a specific dimerization partner of the non-POU domain-containing octamer-binding pr... | Splicing factor, proline- and glutamine-rich | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01174","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGFBP3 interacts with multiple proteins. One interaction is supported by evidence showing that in basal-like TNBC cell lines (HCC1806 and MDA-MB-468)... | |
medium_divergent_branch_01175 | Guanidine interacts with multiple drugs. One of these interacting drugs was identified in a study where in vivo pretreatment with the drug, along with high concentrations of 2-PAM, served as the only effective antagonists against a lethal dose of anatoxin-a(s). Which disease is this specific drug indicated for? | glaucoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01175","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Guanidine interacts with multiple drugs. One of these interacting drugs was identified in a study where in vivo pretreatment with the drug, along wit... | |
medium_divergent_branch_01176 | Glutamic acid is reported to interact with more than one drug. Evidence for one specific interaction states: 'Both transgenic mouse lines had altered sensitivity to this drug albeit in opposite directions.' Which disease is this drug indicated for? | narcolepsy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01176","source_qa_id":"medium_divergent_branch_01004","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Glutamic acid is reported to interact with more than one drug. Evidence for one specific interact... | |
medium_divergent_branch_01177 | RAP2A is involved in multiple biological processes. One of these processes is supported by evidence stating: 'Here, we identify the small G protein Rap2A as a molecular link that couples the formation of microvilli directly to the preceding cell polarization.' Which biological process is positively regulated by the pro... | microvillus assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01177","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAP2A is involved in multiple biological processes. One of these processes is supported by evidence stating: 'Here, we identify the small G protein R... | |
medium_divergent_branch_01178 | AKAP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Analysis of ternary complexes by the yeast two-hybrid system revealed that RIalpha and RIbeta homodimers as well as an RIalpha:RIbeta heterodimer and several of the mutants were able to bind to the R-binding domain of AKAP149/D-A... | neonatal severe primary hyperparathyroidism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01178","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKAP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Analysis of ternary complexes by the yeast two-hybrid syst... | |
medium_divergent_branch_01179 | The gene GSN interacts with multiple partners. One interaction is supported by evidence describing 'The 3.4 angstrom x-ray structure of the carboxyl-terminal half of gelsolin (G4-G6) in complex with actin reveals the basis for gelsolin activation.' Which protein is encoded by the gene that interacts with GSN in this sp... | Actin, alpha skeletal muscle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01179","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GSN interacts with multiple partners. One interaction is supported by evidence describing 'The 3.4 angstrom x-ray structure of the carboxyl-... | |
medium_divergent_branch_01180 | CCND3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Within cyclin D3 complexes, T-loop phosphorylation of this kinase, but not of CDK6, was directly regulated, identifying it as a determining target for cell cycle control by extracellular factors.' Which protein, connected to CCND... | Cyclin-dependent kinase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01180","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCND3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Within cyclin D3 complexes, T-loop phosphorylation of this... | |
medium_divergent_branch_01181 | The gene RNA5SP283 is enriched in multiple cell types. One specific enrichment profile is characterized by a mean expression of 25.81 TPM, a z-score of 1.51, and a fold enrichment of 3.58. Identify the cell type associated with this specific expression profile, and then determine the cell type from which it develops. | classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01181","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RNA5SP283 is enriched in multiple cell types. One specific enrichment profile is characterized by a mean expression of 25.81 TPM, a z-score ... | |
medium_divergent_branch_01183 | KATNB1 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'We demonstrate that phosphorylation of this protein by Cdk5 facilitates interaction between this protein and p60, suggesting that phosphorylated this protein regulates the distribution of katanin p60.' Which... | kinetochore | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01183","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KATNB1 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'We demonstrate that phosphorylation ... | |
medium_divergent_branch_01184 | The gene TIGAR is enriched in multiple cell types. One of these cell types exhibits a mean expression of 23.89 TPM, a z-score of 1.76, and a fold enrichment of 3.52. Which cell type does this specific cell develop from? | classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01184","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TIGAR is enriched in multiple cell types. One of these cell types exhibits a mean expression of 23.89 TPM, a z-score of 1.76, and a fold enr... | |
medium_divergent_branch_01185 | Plakophilin-3 (PKP3) is associated with multiple cellular components. One association is supported by evidence stating that a decrease in PKP3 levels leads to a decrease in the size of this component and impaired cell-cell adhesion. Which cell type contains this specific cellular component as a part? | spinous cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01185","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Plakophilin-3 (PKP3) is associated with multiple cellular components. One association is supported by evidence stating that a decrease in PKP3 levels... | |
medium_divergent_branch_01186 | EXO1 interacts with multiple genes via binding. One specific interaction is supported by evidence stating: 'Here, we demonstrate that hExoI binds strongly to hMLH1, and we describe interaction regions between hExoI and the MMR proteins hMLH1, hMSH2, and hMSH3.' Which disease is associated with this target gene through ... | germ cell tumor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01186","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EXO1 interacts with multiple genes via binding. One specific interaction is supported by evidence stating: 'Here, we demonstrate that hExoI binds str... | |
medium_divergent_branch_01187 | Pyramidal neurons are anatomically associated with specific layers via a 'part of' relationship. One such association is supported by evidence describing a cytoarchitectural term denoting the layer of the hippocampus in which pyramidal cells are predominant. This layer is located superficial to the Stratum oriens; it i... | layer of hippocampus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01187","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Pyramidal neurons are anatomically associated with specific layers via a 'part of' relationship. One such association is supported by evidence descri... | |
medium_divergent_branch_01188 | Envoplakin (EVPL) interacts with multiple proteins. One of these interaction partners is characterized by the following properties: its N-terminal domain interacts with the plasma membrane, it heterodimerizes with envoplakin via its rod domain, and its C-terminus interacts with intermediate filaments. Which biological ... | response to mechanical stimulus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01188","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Envoplakin (EVPL) interacts with multiple proteins. One of these interaction partners is characterized by the following properties: its N-terminal do... | |
medium_divergent_branch_01189 | FOXA2 interacts with multiple proteins. Evidence for one specific interaction indicates that protein-binding assays demonstrated the requirement of the Cut-Homeodomain and the winged-helix DNA binding domains of the interacting partner. Which protein, encoded by the gene connected to FOXA2 via this interaction, is desc... | Hepatocyte nuclear factor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01189","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXA2 interacts with multiple proteins. Evidence for one specific interaction indicates that protein-binding assays demonstrated the requirement of t... | |
medium_divergent_branch_01190 | TRAIP interacts with multiple genes. One of these interaction partners is characterized by experimental evidence stating: 'Both TRIP and its RING mutant interact with TRAF1, 2, 3, 5, and 6, but failed to interact with CYLD and NIK.' Which disease is associated with this specific interaction partner through genomic alte... | plasma cell myeloma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01190","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAIP interacts with multiple genes. One of these interaction partners is characterized by experimental evidence stating: 'Both TRIP and its RING mut... | |
medium_divergent_branch_01191 | MSH6 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we show that each subunit of the human 9-1-1 complex physically interacts with hMSH2, hMSH3, and hMSH6.' Which protein, connected to MSH6 via this interaction, is encoded by the gene in question? | Checkpoint protein HUS1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01191","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MSH6 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we show that each subunit of the human 9-1-1... | |
medium_divergent_branch_01192 | MAPK8 interacts with multiple genes. One interaction is supported by evidence that a target protein was phosphorylated by JNK1 at S411 and S424 in the carboxyl terminal autoinhibitory domain. Which protein is encoded by the gene connected to MAPK8 through this specific interaction? | Ribosomal protein S6 kinase beta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01192","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK8 interacts with multiple genes. One interaction is supported by evidence that a target protein was phosphorylated by JNK1 at S411 and S424 in th... | |
medium_divergent_branch_01193 | RUVBL1 interacts with multiple proteins. One specific interaction is characterized by evidence stating that the partner protein forms oligomers that bind to RuvBL1-RuvBL2 hetero-oligomeric complexes, yet this partner interacts preferentially with RUVBL1. Which protein, connected to RUVBL1 via a binding interaction, mat... | Transcriptional repressor protein YY1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01193","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RUVBL1 interacts with multiple proteins. One specific interaction is characterized by evidence stating that the partner protein forms oligomers that ... | |
medium_divergent_branch_01194 | Circulating IgA immunoglobulin complexes are produced by specific cell types. One such cell type is described as a fully differentiated plasma cell that secretes IgA. Which cell type corresponds to this description, and what is its direct parent class in the cellular hierarchy? | long lived plasma cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01194","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Circulating IgA immunoglobulin complexes are produced by specific cell types. One such cell type is described as a fully differentiated plasma cell t... | |
medium_divergent_branch_01195 | PDCD6IP interacts with multiple genes. One interaction is supported by evidence stating: 'Using the C-terminal domain of D1 receptor as bait, we identified AIP1 (ALG-2 interacting protein 1), a known modulator of caspase-dependent and caspase-independent cell death, including neuronal cell death, that is also part of t... | nasopharyngeal carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01195","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDCD6IP interacts with multiple genes. One interaction is supported by evidence stating: 'Using the C-terminal domain of D1 receptor as bait, we iden... | |
medium_divergent_branch_01196 | The microRNA mmu-miR-181a-5p is known to regulate more than one type of cell. One specific regulatory interaction is supported by evidence stating: 'In human memory TH17 cells, miR-181a regulates responses to cognate antigens through modulation of ERK phosphorylation.' Based on this evidence, which cell type is the tar... | CD4-positive helper T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01196","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The microRNA mmu-miR-181a-5p is known to regulate more than one type of cell. One specific regulatory interaction is supported by evidence stating: '... | |
medium_divergent_branch_01197 | The gene ABHD11 is enriched in multiple cell types. One specific cell type shows a mean expression of 29.56 TPM, a z-score of 1.55, and a fold enrichment of 2.03 for this gene. Which cell type is the developmental precursor to the cell type exhibiting these specific expression statistics? | pro-NK cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01197","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ABHD11 is enriched in multiple cell types. One specific cell type shows a mean expression of 29.56 TPM, a z-score of 1.55, and a fold enrich... | |
medium_divergent_branch_01198 | METTL18 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'We found METTL18 to be a nuclear protein that contains a functional nuclear localization signal and accumulates in nucleoli.' Which cellular component, connected to the component... | nuclear lumen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01198","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"METTL18 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'We foun... | |
medium_divergent_branch_01199 | The gene PPP1R15A interacts with multiple other genes. One of these interacting partners is noted to also interact with GADD34, a regulatory subunit of protein phosphatase 1 (PP1). Which protein is encoded by this specific interacting partner? | CUE domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01199","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP1R15A interacts with multiple other genes. One of these interacting partners is noted to also interact with GADD34, a regulatory subunit ... | |
medium_divergent_branch_01200 | SRA1 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'In addition, a specific protein binds to the steroid receptor RNA coactivator SRA via an intrinsic RNA binding domain and suppresses SRA-potentiated steroid receptor transcription activity.' Which protein is encoded by t... | Msx2-interacting protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01200","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SRA1 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'In addition, a specific protein binds to the ster... | |
medium_divergent_branch_01201 | LARP1 is associated with multiple biological processes. One association is supported by evidence stating: 'We show that LARP1 directly binds the cap and adjacent 5'TOP motif of TOP mRNAs, effectively impeding access of eIF4E to the cap and preventing eIF4F assembly.' Which biological process, connected to the process d... | translational initiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01201","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LARP1 is associated with multiple biological processes. One association is supported by evidence stating: 'We show that LARP1 directly binds the cap ... | |
medium_divergent_branch_01202 | West Nile virus downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.430 and an adjusted p-value of 0.000401. Which protein does that selected gene encode? | Lipid droplet assembly factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01202","source_qa_id":"medium_divergent_branch_05508","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus downregulates several genes. In the recorded experiment, one branch showed a l... | |
medium_divergent_branch_01203 | GATA4 interacts with multiple proteins. One interaction is supported by evidence stating: 'A mechanism for the transcriptional synergy was suggested by the observation that the bHLH domain of a specific bHLH transcription factor physically interacted with the C-terminal zinc finger domain of GATA4 forming a higher orde... | Heart- and neural crest derivatives-expressed protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01203","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA4 interacts with multiple proteins. One interaction is supported by evidence stating: 'A mechanism for the transcriptional synergy was suggested ... | |
medium_divergent_branch_01204 | MYO6 interacts with multiple proteins. One specific interaction was identified through a yeast two-hybrid screen that also identified nuclear dot protein 52 (NDP52) as a myosin VI binding partner. Which protein, linked to MYO6 by this specific interaction evidence, is encoded by the gene in question? | Tax1-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01204","source_qa_id":"medium_divergent_branch_03249","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MYO6 interacts with multiple proteins. One specific interaction was identified through a yeast tw... | |
medium_divergent_branch_01205 | MTHFD1 interacts with multiple genes. One specific interaction is characterized by the finding that the MTHFD1 R653Q variant displays enhanced binding to an E3 ligase, leading to augmented ubiquitination with K504 identified as the primary ubiquitination site. Which disease is associated with the gene involved in this ... | vitiligo | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01205","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTHFD1 interacts with multiple genes. One specific interaction is characterized by the finding that the MTHFD1 R653Q variant displays enhanced bindin... | |
medium_divergent_branch_01206 | NRG1 is associated with multiple biological processes. One of these associations is supported by evidence stating that NRG1 proteins play important roles during the development of the nervous system, heart, and mammary glands. Which biological process, connected to the process described by this evidence via an 'is a' r... | gland development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01206","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NRG1 is associated with multiple biological processes. One of these associations is supported by evidence stating that NRG1 proteins play important r... | |
medium_divergent_branch_01207 | PFN2 interacts with multiple genes. One interaction is supported by evidence stating: 'BIAcore studies demonstrated a high affinity interaction of SMN with profilin IIa, the isoform present in developing neurons.' Which protein is encoded by the gene that interacts with PFN2 in this specific context? | Survival motor neuron protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01207","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PFN2 interacts with multiple genes. One interaction is supported by evidence stating: 'BIAcore studies demonstrated a high affinity interaction of SM... | |
medium_divergent_branch_01208 | BCORL1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The protein encoded by the gene PCGF1 is central in the assembly of the noncanonical PRC1 variant called PRC1.1 through its direct interaction with BCOR (BCL-6-interacting corepressor) or its paralog, BCOR-like 1.' Whic... | Polycomb group RING finger protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01208","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCORL1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The protein encoded by the gene PCGF1 is central... | |
medium_divergent_branch_01209 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.384 and an adjusted p-value of 0.0348. Which protein does that selected gene encode? | Putative uncharacterized protein encoded by LINC01590 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01209","source_qa_id":"medium_divergent_branch_06154","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_01210 | CABIN1 interacts with multiple proteins. One specific interaction is described by the evidence: 'The proline-rich region of cain forms a stable association with the SH3 domain of this protein.' Which gene encodes this interaction partner? | Amphiphysin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01210","source_qa_id":"medium_divergent_branch_07120","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CABIN1 interacts with multiple proteins. One specific interaction is described by the evidence: '... | |
medium_divergent_branch_01211 | FOXM1 interacts with multiple proteins. One of these interactions is characterized by the partner protein specifically binding to FOXM1 during the G2/M transition, leading to FOXM1 ubiquitination and degradation. Which protein corresponds to this specific interaction partner? | F-box only protein 31 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01211","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXM1 interacts with multiple proteins. One of these interactions is characterized by the partner protein specifically binding to FOXM1 during the G2... | |
medium_divergent_branch_01212 | JOSD2 interacts with multiple proteins. One of these interactions is characterized by the mechanism where JOSD2 directly interacts with and stabilizes the partner protein's variants across different mutants by reverting their proteolytic ubiquitination. Which protein is this partner, and what is the name of the protein... | GTPase KRas | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01212","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JOSD2 interacts with multiple proteins. One of these interactions is characterized by the mechanism where JOSD2 directly interacts with and stabilize... | |
medium_divergent_branch_01213 | The gene DCLRE1B (also known as Apollo or hSnm1B) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Furthermore, the C terminus of hSnm1B was shown to interact with the TRF homology domain of the protein encoded by the gene connected to DCLRE1B through this specific interacti... | Telomeric repeat-binding factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01213","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DCLRE1B (also known as Apollo or hSnm1B) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Furth... | |
medium_divergent_branch_01214 | IL1RAPL1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We also found that IL1RAPL1 TIR domains interact with a RhoGAP protein, which is localized at the excitatory post-synaptic density.' Which protein, connected to IL1RAPL1 via this specific interaction evidence, is encoded by th... | Rho GTPase-activating protein 22 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01214","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL1RAPL1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We also found that IL1RAPL1 TIR domains interact with a... | |
medium_divergent_branch_01215 | The biological process 'positive regulation of dendrite morphogenesis' is defined as any process that activates or increases the frequency, rate, or extent of dendrite morphogenesis. This process is a subtype of a broader biological process. Which biological process is positively regulated by that broader process? | cell projection organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01215","source_qa_id":"medium_divergent_branch_00570","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'positive regulation of dendrite morphogenesis' is defined as any process ... | |
medium_divergent_branch_01217 | KLHL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that KLHL2, as well as KLHL3, was co-immunoprecipitated with all four WNK isoforms.' Which protein, connected to KLHL2 via an interaction, is the subject of this specific evidence? | Serine/threonine-protein kinase WNK3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01217","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLHL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that KLHL2, as well as KLHL3, was co-immunoprecip... | |
medium_divergent_branch_01218 | BRCA1 is involved in multiple biological processes. One such process is supported by evidence that BRCA1 overexpression strongly attenuated the production of reactive oxygen species and upregulated endothelial nitric oxide synthase, phosphorylated endothlicial nitric oxide synthase, phosphorylated Akt, and vascular end... | gene expression | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01218","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRCA1 is involved in multiple biological processes. One such process is supported by evidence that BRCA1 overexpression strongly attenuated the produ... | |
medium_divergent_branch_01219 | NOD1 interacts with multiple proteins. One specific interaction was confirmed using co-immunoprecipitation (co-IP) and glutathione S-transferase (GST)-pull down assays. Which protein, among those interacting with NOD1, is the subject of this specific experimental evidence, and what protein product does the gene for thi... | E3 ubiquitin-protein ligase RNF34 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01219","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOD1 interacts with multiple proteins. One specific interaction was confirmed using co-immunoprecipitation (co-IP) and glutathione S-transferase (GST... | |
medium_divergent_branch_01220 | DLGAP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using the PDZ domains of ProSAP1 and 2 as bait in the yeast two-hybrid system, we isolated several clones of the SAPAP/GKAP (SAP90/PSD-95-associated protein/guanylate kinase-associated protein) family.' Which protein, encoded by... | SH3 and multiple ankyrin repeat domains protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01220","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLGAP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using the PDZ domains of ProSAP1 and 2 as bait in the yea... | |
medium_divergent_branch_01221 | LGR5 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Here we demonstrate that LGR4 and LGR5 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphoryla... | signaling receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01221","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LGR5 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Here... | |
medium_divergent_branch_01222 | Aquaporin-1 (AQP1) is associated with multiple molecular functions. One specific function is supported by evidence stating that AQP1 channels are constitutively active water channels allowing rapid transmembrane osmotic water flux, and also serve as cyclic-GMP-gated ion channels. Which biological process is connected t... | water transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01222","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Aquaporin-1 (AQP1) is associated with multiple molecular functions. One specific function is supported by evidence stating that AQP1 channels are con... | |
medium_divergent_branch_01223 | The KCNH2 gene (encoding the HERG potassium channel) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using transfections of U-2 OS and HEK293 cells, Western blot analysis and immunocytochemistry data demonstrate that this protein and the human ether-a-go-go-related gene (HE... | RING finger protein 207 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01223","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The KCNH2 gene (encoding the HERG potassium channel) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Us... | |
medium_divergent_branch_01224 | DDB2 interacts with multiple genes. One interaction is supported by evidence stating: 'We show here that the protein encoded by the gene interacting with DDB2 interacts with the Cul4A-DDB1 E3 ubiquitin ligase via a direct interaction with the substrate-specificity receptor DDB2.' Which cellular component is the gene id... | nonhomologous end joining complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01224","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDB2 interacts with multiple genes. One interaction is supported by evidence stating: 'We show here that the protein encoded by the gene interacting ... | |
medium_divergent_branch_01225 | NFAT5 interacts with multiple proteins. One interaction is supported by evidence stating that the Rel-homology domain of TonEBP (encoded by NFAT5), which encircles DNA, was essential for the interaction with the partner protein, as well as for PCNA polyubiquitination and cell survival after DNA damage. Which protein is... | Ubiquitin carboxyl-terminal hydrolase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01225","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFAT5 interacts with multiple proteins. One interaction is supported by evidence stating that the Rel-homology domain of TonEBP (encoded by NFAT5), w... | |
medium_divergent_branch_01227 | Orthohepevirus A upregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of 1.153 and an adjusted p-value of 0.03654. Which molecular function is enabled by the gene corresponding to this specific evidence? | protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01227","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Orthohepevirus A upregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of 1.153 and an adjusted p-value... | |
medium_divergent_branch_01228 | IGF1R interacts with multiple genes. One interaction is supported by evidence showing that Glutathione S-transferase-hSOCS-2 associates with activated IGF-IR in lysates of mouse fibroblasts overexpressing IGF-IR. Which disease is connected to this specific interacting gene through genomic alterations? | acute hemorrhagic leukoencephalitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01228","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGF1R interacts with multiple genes. One interaction is supported by evidence showing that Glutathione S-transferase-hSOCS-2 associates with activate... | |
medium_divergent_branch_01229 | The gene SERP1 is known to interact with multiple other genes. One specific interaction is supported by evidence stating: 'In a split-ubiquitin-based two-hybrid screening, we identified stress-associated ER protein 1 (SERP1)/ribosome-associated membrane protein 4 as a novel interacting partner for the ENaC β-subunit.' ... | Epithelial sodium channel subunit beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01229","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SERP1 is known to interact with multiple other genes. One specific interaction is supported by evidence stating: 'In a split-ubiquitin-based... | |
medium_divergent_branch_01230 | GLI1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Since these proteins co-overexpress in breast tumors, we examined whether they form complexes and observed that the protein interacted with both GLI1 and tGLI1.' Which protein product is encoded by the gene corresponding to this i... | Signal transducer and activator of transcription 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01230","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GLI1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Since these proteins co-overexpress in breast tumors, we ex... | |
medium_divergent_branch_01231 | The rib cartilage element is a subclass of two distinct anatomical structures. One of these structures is described in the evidence as being composed primarily of cartilage tissue. Which of these two structures is the rib cartilage element a part of? | rib skeletal system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01231","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The rib cartilage element is a subclass of two distinct anatomical structures. One of these structures is described in the evidence as being composed... | |
medium_divergent_branch_01232 | FNDC3A interacts with multiple proteins. One of these interaction partners is involved in a role that requires interaction with the ER membrane resident proteins FNDC3A and FNDC3B. Which protein is encoded by the gene corresponding to this specific interaction partner? | Terminal nucleotidyltransferase 5C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01232","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FNDC3A interacts with multiple proteins. One of these interaction partners is involved in a role that requires interaction with the ER membrane resid... | |
medium_divergent_branch_01233 | DLG4 interacts with multiple proteins. One interaction partner is described as a novel protein that is highly conserved from mammals to plants and binds selectively to the third PDZ domain (PDZ3) of PSD-95 via its C terminus. Which protein is encoded by the gene corresponding to this interaction partner? | Cysteine-rich PDZ-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01233","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLG4 interacts with multiple proteins. One interaction partner is described as a novel protein that is highly conserved from mammals to plants and bi... | |
medium_divergent_branch_01235 | STAT1 interacts with multiple proteins. One interaction is supported by evidence stating: 'A new factor, most likely a [protein]-STAT1 heterodimer, was detected with an IR probe in extracts of IFN-alpha-treated cells.' Which protein, encoded by the gene connected to STAT1 via this interaction, is the subject of this ev... | Signal transducer and activator of transcription 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01235","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STAT1 interacts with multiple proteins. One interaction is supported by evidence stating: 'A new factor, most likely a [protein]-STAT1 heterodimer, w... | |
medium_divergent_branch_01236 | The gene DLST interacts with multiple partners. One specific interaction is supported by evidence stating: 'Moreover, a high affinity interaction has been demonstrated between the homodimeric E1 and E3 components, which form a stable subcomplex comprising single copies of these two enzymes.' Which protein is encoded by... | 2-oxoglutarate dehydrogenase complex component E1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01236","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DLST interacts with multiple partners. One specific interaction is supported by evidence stating: 'Moreover, a high affinity interaction has... | |
medium_divergent_branch_01237 | BRF1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Pull-down assays and immunoprecipitations using recombinant components demonstrate that a subunit of TFIIIB interacts physically with a retinoblastoma family protein and p130.' Which disease is causally linked to the gene i... | adenoviridae infectious disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01237","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRF1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Pull-down assays and immunoprecipitations using reco... | |
medium_divergent_branch_01238 | TWIST1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We also found that this protein can directly interact with Twist1 and specifically cleave the K48-linked polyubiquitin chains of Twist1 induced by FBXL14.' What is the full protein name encoded by the gene corresponding to this ... | Ubiquitin carboxyl-terminal hydrolase 13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01238","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TWIST1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We also found that this protein can directly interact wit... | |
medium_divergent_branch_01239 | TDG interacts with multiple proteins. One interaction is supported by evidence stating: 'Yeast two-hybrid analysis indicated a physical interaction between a region including the oligomerization domain (OD) of p73alpha (residues 345-380) or p53 (residues 319-360) and residues 123-346 of TDG, which localizes in the G/T ... | aneuploidy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01239","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TDG interacts with multiple proteins. One interaction is supported by evidence stating: 'Yeast two-hybrid analysis indicated a physical interaction b... | |
medium_divergent_branch_01240 | MAP3K7 interacts with multiple proteins. One of these interaction partners has been shown via coimmunoprecipitation to interact with TGFβ activated kinase 1 (TAK1), a serine/threonine kinase essential for TNFα- and IL-1β-induced NF-κB activation. Which protein, connected to MAP3K7 through an interaction, is described b... | E3 ubiquitin-protein ligase TRIM8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01240","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K7 interacts with multiple proteins. One of these interaction partners has been shown via coimmunoprecipitation to interact with TGFβ activated k... | |
medium_divergent_branch_01241 | MKRN1 interacts with multiple genes. One of these interaction partners is a target of MKRN1-mediated ubiquitination, as identified using the yeast two-hybrid method. Which disease is genetically associated with this specific interaction partner? | myelofibrosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01241","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MKRN1 interacts with multiple genes. One of these interaction partners is a target of MKRN1-mediated ubiquitination, as identified using the yeast tw... | |
medium_divergent_branch_01242 | EPHA2 is associated with multiple biological processes. One association is supported by evidence stating: 'While activation of EPHA2 with its ligand ephrin-A1 inhibited chemotactic migration of glioma and prostate cancer cells, EPHA2 overexpression promoted migration in a ligand-independent manner.' Which biological pr... | cellular response to chemical stimulus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01242","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPHA2 is associated with multiple biological processes. One association is supported by evidence stating: 'While activation of EPHA2 with its ligand ... | |
medium_divergent_branch_01243 | O-GlcNAc transferase (OGT) is associated with multiple biological processes. One specific association is supported by evidence that OGT catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine (UDP-GlcNAc) to the serine and threonine residues of cytoplasmic, nuclear, and mitochondrial proteins. Which ... | glycoprotein biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01243","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"O-GlcNAc transferase (OGT) is associated with multiple biological processes. One specific association is supported by evidence that OGT catalyzes the... | |
medium_divergent_branch_01244 | Human respirovirus 3 is reported to upregulate multiple genes. One specific upregulation event is characterized by a log2 fold change of approximately 2.83 and an adjusted p-value of approximately 0.042. Which protein is encoded by the gene associated with this specific statistical signature? | A disintegrin and metalloproteinase with thrombospondin motifs 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01244","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human respirovirus 3 is reported to upregulate multiple genes. One specific upregulation event is characterized by a log2 fold change of approximatel... | |
medium_divergent_branch_01247 | TNRC6B interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'In D. melanogaster cells, the second binding site dominates; however, in HsTNRC6A-C the PAM2 motif is essential for binding to both Hs and DmPABPC1.' Identify the protein described in this evidence, and then s... | Polyadenylate-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01247","source_qa_id":"medium_divergent_branch_03235","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"TNRC6B interacts with multiple proteins. One specific interaction is characterized by the followi... | |
medium_divergent_branch_01248 | FYB1 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We establish that a specific Src kinase-associated phosphoprotein and SLAP-130 associate with each other when both molecules are co-expressed in COS cells.' Which protein, linked to FYB1 by an interaction, is t... | Src kinase-associated phosphoprotein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01248","source_qa_id":"medium_divergent_branch_06746","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FYB1 is known to interact with multiple proteins. One specific interaction is supported by eviden... | |
medium_divergent_branch_01249 | MID1 interacts with multiple genes. One of these interactions is characterized by the finding that circPDE4B facilitates the association between MID1 and the partner gene by acting as a scaffold to promote the partner's degradation through the proteasome. Which gene is this partner? | SDCBP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01249","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MID1 interacts with multiple genes. One of these interactions is characterized by the finding that circPDE4B facilitates the association between MID1... |
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