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medium_divergent_branch_01250 | CXCR3 is associated with multiple biological processes. One association is supported by evidence stating that overexpression of CXCR3 dramatically reduced DNA synthesis and up-regulated apoptotic HMEC-1 death through activation of distinct signal transduction pathways. Which biological process, connected to CXCR3 via t... | execution phase of apoptosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01250","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXCR3 is associated with multiple biological processes. One association is supported by evidence stating that overexpression of CXCR3 dramatically re... | |
medium_divergent_branch_01252 | MCRS1 interacts with multiple genes. One of these interaction partners is supported by evidence showing that MCRS2 interacts with it in vitro and in vivo, and colocalizes with it in cells. Which disease is associated with this specific interaction partner? | hepatoblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01252","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCRS1 interacts with multiple genes. One of these interaction partners is supported by evidence showing that MCRS2 interacts with it in vitro and in ... | |
medium_divergent_branch_01253 | CDK5 is implicated in multiple biological processes. One of these processes is characterized by its normal association with neuronal functions such as migration, cortical layering, and synaptic plasticity. What is the parent biological process (via an 'is a' relationship) of this specific CDK5-associated process? | anterograde trans-synaptic signaling | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01253","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK5 is implicated in multiple biological processes. One of these processes is characterized by its normal association with neuronal functions such a... | |
medium_divergent_branch_01254 | MUC1 interacts with multiple genes. One interaction is supported by evidence stating: 'The present results demonstrate that MUC1 associates with protein kinase Cdelta (PKCdelta).' Which disease is connected to this interaction partner through a biomarker relationship? | cervical squamous cell carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01254","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MUC1 interacts with multiple genes. One interaction is supported by evidence stating: 'The present results demonstrate that MUC1 associates with prot... | |
medium_divergent_branch_01255 | ATP13A2 is associated with multiple biological processes. One association is supported by evidence showing that Cathepsin D activity was decreased in ATP13A2-knockdown cells, which displayed lysosome-like bodies characterized by fingerprint-like structures. Which biological process, connected to the process supported b... | lysosomal protein catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01255","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATP13A2 is associated with multiple biological processes. One association is supported by evidence showing that Cathepsin D activity was decreased in... | |
medium_divergent_branch_01256 | HSPA9 (mortalin) interacts with multiple gene products. One specific interaction is supported by evidence stating that Mevalonate pyrophosphate decarboxylase was identified as a mortalin binding partner. Which protein is encoded by the gene corresponding to this specific interacting partner? | Diphosphomevalonate decarboxylase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01256","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSPA9 (mortalin) interacts with multiple gene products. One specific interaction is supported by evidence stating that Mevalonate pyrophosphate decar... | |
medium_divergent_branch_01257 | ERBB2 interacts with multiple proteins. One interaction is characterized by the observation that the partners co-immunoprecipitate from cell lysates and associate directly in vitro. Which protein, connected to ERBB2 via this specific binding evidence, is the subject of the 'encodes' relation? | Growth factor receptor-bound protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01257","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERBB2 interacts with multiple proteins. One interaction is characterized by the observation that the partners co-immunoprecipitate from cell lysates ... | |
medium_divergent_branch_01258 | PDE4B interacts with multiple proteins. One of these interacting partners has been shown to activate the cAMP-PKA-CREB pathway by interacting with PDE4B and facilitating its degradation. Which protein, connected to PDE4B via an interaction, is the one described in this evidence? | E3 ubiquitin-protein ligase SMURF2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01258","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDE4B interacts with multiple proteins. One of these interacting partners has been shown to activate the cAMP-PKA-CREB pathway by interacting with PD... | |
medium_divergent_branch_01259 | CDK6 is associated with multiple biological processes. One association is supported by evidence stating: 'This novel kinase was found to partner with the D-type cyclins and to possess pRb kinase activity in vitro and has since been understood to function solely as a pRb kinase in the regulation of the G(1) phase of the... | regulation of cellular process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01259","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK6 is associated with multiple biological processes. One association is supported by evidence stating: 'This novel kinase was found to partner with... | |
medium_divergent_branch_01260 | MCF2L interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'Although this protein has not been shown to be a substrate for Dbs in either in vitro or in vivo assays, the Rat ortholog of Dbs (Ost) has been shown to bind specifically to GTP-bound forms of this protein... | Ras-related C3 botulinum toxin substrate 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01260","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCF2L interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'Although this protein has not been... | |
medium_divergent_branch_01261 | The gustatory epithelium of the palate is a component of a specific anatomical structure, described in evidence as being part of the roof of the mouth. This structure is itself a part of a larger body region. What is this larger body region? | head | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01261","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gustatory epithelium of the palate is a component of a specific anatomical structure, described in evidence as being part of the roof of the mout... | |
medium_divergent_branch_01262 | JUNB interacts with multiple genes. One of these interacting partners is characterized by biochemical evidence showing that it binds to JUNB via a PY motif and targets JUNB for ubiquitination and proteasomal degradation. Which disease is associated with this specific interacting gene as a biomarker? | lung cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01262","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JUNB interacts with multiple genes. One of these interacting partners is characterized by biochemical evidence showing that it binds to JUNB via a PY... | |
medium_divergent_branch_01263 | TGFBR2 interacts with multiple genes. One of these interacting partners is known to directly deubiquitinate and stabilize the type II TGF-β receptor (TβRII), thereby increasing its expression in the plasma membrane and in tumor-derived extracellular vesicles (TEVs). Which disease is associated with genomic alterations ... | ACTH-dependent Cushing syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01263","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TGFBR2 interacts with multiple genes. One of these interacting partners is known to directly deubiquitinate and stabilize the type II TGF-β receptor ... | |
medium_divergent_branch_01265 | FGF13 interacts with multiple proteins. One of these interactions is supported by experimental evidence from Affinity Capture-Western and Two-hybrid assays. Which protein, encoded by the gene interacting with FGF13 in this specific manner, is the target of the 'encodes' relationship? | SHC SH2 domain-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01265","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF13 interacts with multiple proteins. One of these interactions is supported by experimental evidence from Affinity Capture-Western and Two-hybrid ... | |
medium_divergent_branch_01266 | NFE2L2 (NRF2) interacts with multiple proteins. One specific interaction involves a protein that binds the DIDLID sequence within the Neh2 domain of NRF2 to regulate its stability, a mechanism that is independent of the KEAP1-binding DLG or ETGE motifs. Which protein, encoded by the gene connected to NFE2L2 via this sp... | DDB1- and CUL4-associated factor 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01266","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFE2L2 (NRF2) interacts with multiple proteins. One specific interaction involves a protein that binds the DIDLID sequence within the Neh2 domain of ... | |
medium_divergent_branch_01267 | FOXP1 interacts with multiple genes. One of these interacting partners belongs to a family where Subdomain 1 contains a highly conserved leucine zipper similar to that found in N-myc, conferring homo- and heterodimerization capabilities to the Foxp1/2/4 family members. Which disease is associated with this specific int... | bipolar disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01267","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXP1 interacts with multiple genes. One of these interacting partners belongs to a family where Subdomain 1 contains a highly conserved leucine zipp... | |
medium_divergent_branch_01268 | CDK11A is associated with multiple biological processes. One association is supported by evidence stating: 'Our previous study proved that CDK11(p58)-enhanced cycloheximide (CHX)-induced apoptosis in SMMC-7721 hepatocarcinoma cells.' Identify the biological process linked to this specific association via an 'is a' rela... | regulation of programmed cell death | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01268","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK11A is associated with multiple biological processes. One association is supported by evidence stating: 'Our previous study proved that CDK11(p58)... | |
medium_divergent_branch_01269 | RASSF1 interacts with multiple genes. Evidence for one partner reports that seventy percent of the interacting clones showed homology to microtubule-associated proteins, including that partner and VCY2IP1/C19ORF5. Which additional gene is bound by the RASSF1-interacting partner best supported by this evidence? | PAFAH1B1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01269","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RASSF1 interacts with multiple genes. Evidence for one partner reports that seventy percent of the interacting clones showed homology to microtubule-... | |
medium_divergent_branch_01270 | IFNAR1 interacts with multiple genes. One of these interacting partners is a secreted protein that binds to IFNAR1 and triggers its degradation, a mechanism that facilitates viral evasion from cellular innate immunity. Which disease is causally linked to this specific interacting gene? | recurrent acute pancreatitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01270","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IFNAR1 interacts with multiple genes. One of these interacting partners is a secreted protein that binds to IFNAR1 and triggers its degradation, a me... | |
medium_divergent_branch_01271 | ZMYM2 interacts with multiple genes. One of these interaction partners was identified in a study reporting seven novel FOXP-interacting transcription factors (NR2F1, NR2F2, SATB1, SATB2, SOX5, YY1, and this gene), noting that five of these have well-established roles in cortical development. Which disease is associated... | Silver-Russell syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01271","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZMYM2 interacts with multiple genes. One of these interaction partners was identified in a study reporting seven novel FOXP-interacting transcription... | |
medium_divergent_branch_01272 | The gene CLN5 is associated with multiple cellular components via the 'located in' relationship. One specific evidence statement notes that 'All forms were targeted to lysosomes and the longest form, translated from the first potential methionine, was associated with membranes.' Based on this specific textual evidence,... | cellular anatomical structure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01272","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CLN5 is associated with multiple cellular components via the 'located in' relationship. One specific evidence statement notes that 'All form... | |
medium_divergent_branch_01273 | The gene SLC11A2 is associated with multiple molecular functions. One specific association is supported by evidence stating: 'Mutations of interacting residues affect ion binding and transport in both ScaDMT and human DMT1.' Identify the parent molecular function (via an 'is a' relationship) of the specific function li... | metal ion transmembrane transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01273","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SLC11A2 is associated with multiple molecular functions. One specific association is supported by evidence stating: 'Mutations of interactin... | |
medium_divergent_branch_01274 | BIRC2 (cIAP2) interacts with multiple proteins. One interaction is characterized by the finding that cIAP2 normally inhibits antigen receptor signaling by mediating the ubiquitination and degradation of a specific protein, which is a critical component for antigenic signaling to NF-kappaB. Which protein, encoded by the... | B-cell lymphoma/leukemia 10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01274","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIRC2 (cIAP2) interacts with multiple proteins. One interaction is characterized by the finding that cIAP2 normally inhibits antigen receptor signali... | |
medium_divergent_branch_01276 | DNM2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report that dynamin-2 specifically interacts with members of the Shank/ProSAP family of postsynaptic density scaffolding proteins.' Which protein, connected to DNM2 via this interaction, is encoded by the gene in question? | SH3 and multiple ankyrin repeat domains protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01276","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNM2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report that dynamin-2 specifically interacts with member... | |
medium_divergent_branch_01277 | The gene EIF2S3 interacts with multiple other genes. One of these interacting partners is described by the following evidence: 'These experiments revealed that this protein interacts with and can methylate eukaryotic translation initiation factor 2 alpha (eIF2α), in vitro and in breast cancer cells.' Which protein is e... | Protein arginine N-methyltransferase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01277","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF2S3 interacts with multiple other genes. One of these interacting partners is described by the following evidence: 'These experiments rev... | |
medium_divergent_branch_01278 | The MEN1 gene product interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We demonstrate here that these discordant functions are unified by menin's ability to serve as a molecular adaptor that physically links the MLL (mixed-lineage leukemia) histone methyltransferase with a c... | PC4 and SFRS1-interacting protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01278","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The MEN1 gene product interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We demonstrate here that these di... | |
medium_divergent_branch_01279 | The gene ABL2 interacts with multiple partners. One specific interaction partner is described as a substrate of Arg and v-Abl that associates with these kinases and is phosphorylated on tyrosine in v-Abl-transformed cells. Which disease is associated with this specific interaction partner via a biomarker relationship? | breast fibrocystic disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01279","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ABL2 interacts with multiple partners. One specific interaction partner is described as a substrate of Arg and v-Abl that associates with th... | |
medium_divergent_branch_01280 | The gene EFNB1 is associated with multiple protein partners via binding interactions. One specific interaction is supported by the following evidence: 'Here we show that the SH2/SH3 domain adaptor protein Grb4 binds to the cytoplasmic domain of B ephrins in a phosphotyrosine-dependent manner.' Identify the protein enco... | Cytoplasmic protein NCK2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01280","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EFNB1 is associated with multiple protein partners via binding interactions. One specific interaction is supported by the following evidence... | |
medium_divergent_branch_01281 | FHL1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interaction between FHL1 and myosin-binding protein C was confirmed using co-immunoprecipitation of recombinant and endogenous proteins.' Which gene encodes the protein that interacts with FHL1 in this specific contex... | Myosin-binding protein C, slow-type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01281","source_qa_id":"medium_divergent_branch_06491","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FHL1 interacts with multiple proteins. One specific interaction is supported by evidence stating:... | |
medium_divergent_branch_01282 | CTCF interacts with multiple proteins. One specific interaction is supported by evidence stating that the two entities are coprecipitated from nuclear extracts using antibodies specific for either protein and that they interact in a two-hybrid system. Which protein product is encoded by the gene corresponding to this i... | Polycomb protein SUZ12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01282","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CTCF interacts with multiple proteins. One specific interaction is supported by evidence stating that the two entities are coprecipitated from nuclea... | |
medium_divergent_branch_01283 | Vimentin (VIM) interacts with multiple proteins. One specific interaction was validated by co-immunoprecipitation, as part of a study that identified 18 high-confidence interactors for the partner protein. Which protein, encoded by the gene connected to VIM via this specific interaction, is the subject of that validati... | Ankyrin repeat domain-containing protein 55 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01283","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Vimentin (VIM) interacts with multiple proteins. One specific interaction was validated by co-immunoprecipitation, as part of a study that identified... | |
medium_divergent_branch_01284 | SNIP1 interacts with multiple proteins. One of these interaction partners is described as specifically interacting with SNIP1 to form a complex with SMAD4 and p300 histone acetyltransferase (HAT), which are major transcriptional regulators of the TGF-β signaling pathway. Which protein corresponds to this description? | Zinc finger protein DPF3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01284","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNIP1 interacts with multiple proteins. One of these interaction partners is described as specifically interacting with SNIP1 to form a complex with ... | |
medium_divergent_branch_01285 | FGF12 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'We have demonstrated that FGF12 is localized to the [component], where it interacts with NOLC1 and TCOF1, proteins involved in the assembly of functional ribosomes.' Based... | nuclear lumen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01285","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF12 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: '... | |
medium_divergent_branch_01286 | The rib cartilage element is a subtype of two distinct anatomical structures. One of these parent structures is defined as an entity composed primarily of cartilage tissue. Which parent structure is connected to the rib cartilage element via the 'is a' relationship? | endochondral element | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01286","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The rib cartilage element is a subtype of two distinct anatomical structures. One of these parent structures is defined as an entity composed primari... | |
medium_divergent_branch_01287 | ASB4 interacts with multiple proteins. One of these interaction partners is known to interact with the factor inhibiting HIF1alpha (FIH) and serves as a substrate for FIH-mediated hydroxylation via an oxygen-dependent mechanism. Which protein, encoded by the gene connected to ASB4 through this specific interaction, is ... | Hypoxia-inducible factor 1-alpha inhibitor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01287","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ASB4 interacts with multiple proteins. One of these interaction partners is known to interact with the factor inhibiting HIF1alpha (FIH) and serves a... | |
medium_divergent_branch_01288 | SIVA1 interacts with multiple proteins. One specific interaction partner is identified in a study where the search for partners of a proapoptotic protein involved in T-cell apoptosis via a caspase-dependent mitochondrial pathway led to the identification of SIVA1. Which protein is this interaction partner? | E3 ubiquitin-protein ligase XIAP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01288","source_qa_id":"medium_divergent_branch_01626","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SIVA1 interacts with multiple proteins. One specific interaction partner is identified in a study... | |
medium_divergent_branch_01289 | RC3H2 interacts with multiple proteins. One of these interaction partners is a tyrosine phosphatase that specifically interacts with Roquin2 through its phosphatase domain and dephosphorylates Roquin2 at tyrosine 691. Which protein is encoded by the gene corresponding to this specific interaction partner? | Tyrosine-protein phosphatase non-receptor type 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01289","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RC3H2 interacts with multiple proteins. One of these interaction partners is a tyrosine phosphatase that specifically interacts with Roquin2 through ... | |
medium_divergent_branch_01290 | EIF3B interacts with multiple genes. One specific interaction is supported by evidence stating: 'Immunoprecipitation coupled with mass spectroscopy identified eIF3 subunit b as a novel binding partner.' Which disease is associated with the gene identified in this specific interaction? | malignant glioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01290","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF3B interacts with multiple genes. One specific interaction is supported by evidence stating: 'Immunoprecipitation coupled with mass spectroscopy i... | |
medium_divergent_branch_01291 | LRP1 interacts with multiple proteins. One interaction involves a 39-kDa polypeptide, termed the receptor-associated protein, which interacts with the 515-kDa subunit after biosynthesis and remains associated on the cell surface. Which protein is encoded by the gene corresponding to this interacting partner? | Alpha-2-macroglobulin receptor-associated protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01291","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRP1 interacts with multiple proteins. One interaction involves a 39-kDa polypeptide, termed the receptor-associated protein, which interacts with th... | |
medium_divergent_branch_01292 | BMI1 interacts with multiple proteins. One of these interacting partners is reported to directly deubiquitinate BMI1 and stabilize the BMI1 protein. Which protein, encoded by the gene corresponding to this specific interacting partner, is the subject of this description? | Ubiquitin carboxyl-terminal hydrolase 15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01292","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMI1 interacts with multiple proteins. One of these interacting partners is reported to directly deubiquitinate BMI1 and stabilize the BMI1 protein. ... | |
medium_divergent_branch_01293 | MSH6 interacts with multiple genes. One of these interacting partners is described in experimental evidence as interacting with hMSH2 and hMSH6 proteins and phosphorylating both. Which disease is connected to this specific interacting partner through genomic alterations? | adult acute lymphoblastic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01293","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MSH6 interacts with multiple genes. One of these interacting partners is described in experimental evidence as interacting with hMSH2 and hMSH6 prote... | |
medium_divergent_branch_01294 | MAPK8IP2 interacts with multiple proteins. One interaction is supported by evidence stating that IB2/JIP2 acts as a scaffold for the p38 mitogen-activated protein (MAP) kinase cascade by binding to the Rac target MLK3, the MAP kinase kinase MAP2K3, and the p38 MAP kinase. Which protein, connected to MAPK8IP2 via this s... | Dual specificity mitogen-activated protein kinase kinase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01294","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK8IP2 interacts with multiple proteins. One interaction is supported by evidence stating that IB2/JIP2 acts as a scaffold for the p38 mitogen-acti... | |
medium_divergent_branch_01295 | STX4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Within the syntaxin family, syntaxin 4 interacted with SNAP23 and all vesicle-associated membrane proteins (VAMPs) examined, except tetanus neurotoxin insensitive VAMP (TI-VAMP).' Which disease is associated with the protein ident... | Alzheimer disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01295","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Within the syntaxin family, syntaxin 4 interacted with SNAP... | |
medium_divergent_branch_01296 | RAB7A interacts with multiple genes. One specific interaction is supported by evidence stating: 'We show that membrane recruitment of retromer is mediated by bivalent recognition of an effector of PI3K, this gene, and the RAB7A GTPase, by the VPS35 retromer subunit.' Which disease is associated with this gene via a bio... | MMEP syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01296","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB7A interacts with multiple genes. One specific interaction is supported by evidence stating: 'We show that membrane recruitment of retromer is med... | |
medium_divergent_branch_01297 | The retinal pigment epithelial cell is a subtype of two distinct anatomical categories. One of these categories is defined by its role in housing visual pigments. Which anatomical structure is the retinal pigment epithelial cell a part of, via the category associated with visual pigments? | eye | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01297","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The retinal pigment epithelial cell is a subtype of two distinct anatomical categories. One of these categories is defined by its role in housing vis... | |
medium_divergent_branch_01298 | USP19 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'We demonstrate a direct interaction between USP19 and the protein encoded by the gene interacting with USP19 in this context by pull down assay.' Which protein product is encoded by the gene that interacts with USP19 in... | Cellular tumor antigen p53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01298","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP19 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'We demonstrate a direct interaction between USP1... | |
medium_divergent_branch_01299 | Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.095 and an adjusted p-value of 0.0287. Which disease is associated with that selected gene? | melanoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01299","source_qa_id":"medium_divergent_branch_07286","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one bra... | |
medium_divergent_branch_01300 | RAB11FIP5 interacts with multiple proteins. One specific interaction is described by the evidence: 'In the present study we identify the class I FIPs as dual Rab-binding proteins by demonstrating that they also interact with this protein in a GTP-dependent manner.' Which protein is encoded by the gene corresponding to ... | Ras-related protein Rab-14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01300","source_qa_id":"medium_divergent_branch_01536","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RAB11FIP5 interacts with multiple proteins. One specific interaction is described by the evidence... | |
medium_divergent_branch_01301 | NR5A1 (SF-1) interacts with multiple proteins. One interaction is supported by evidence stating: 'Coimmunoprecipitation cross-linking experiments indicated that SF-1 physically interacts with this partner in vitro.' Which protein, encoded by the gene connected to NR5A1 via this specific interaction, is the subject of t... | Transcription factor Sp1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01301","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NR5A1 (SF-1) interacts with multiple proteins. One interaction is supported by evidence stating: 'Coimmunoprecipitation cross-linking experiments ind... | |
medium_divergent_branch_01303 | The protein ACTC1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence describing 'unregulated (i.e. actin) and regulated thin filaments'. Which cellular component, linked to this specific location by the 'is a' relationship, represents the... | polymeric cytoskeletal fiber | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01303","source_qa_id":"medium_divergent_branch_00373","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein ACTC1 is associated with multiple cellular components via the 'located in' relationsh... | |
medium_divergent_branch_01305 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.044 and an adjusted p-value of 0.0493. Which protein does that selected gene encode? | Zinc finger CCHC domain-containing protein 18 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01305","source_qa_id":"medium_divergent_branch_01854","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_01306 | FYN interacts with multiple proteins. One interaction partner is supported by evidence stating that a protein alias and SKAP55 are proteins with a molecular weight of 55 kDa associated with the SH2 domain of FYN. Which protein, connected to FYN via an interaction, is encoded by the gene corresponding to this specific i... | Src kinase-associated phosphoprotein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01306","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FYN interacts with multiple proteins. One interaction partner is supported by evidence stating that a protein alias and SKAP55 are proteins with a mo... | |
medium_divergent_branch_01307 | NR5A2 interacts with multiple proteins. One interaction is supported by mechanistic studies using co-immunoprecipitation, GST pull-down, and molecular docking, which demonstrated that a specific chaperone protein and the SUMO E3 ligase RanBP2 competitively bind to NR5A2 at sites spanning amino acids 507 to 539. Which p... | Endoplasmin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01307","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NR5A2 interacts with multiple proteins. One interaction is supported by mechanistic studies using co-immunoprecipitation, GST pull-down, and molecula... | |
medium_divergent_branch_01308 | PTPN1 interacts with multiple genes. One of these interacting partners is supported by evidence stating that it co-immunoprecipitates with Plk1 and endogenous PTP1B from mitotic cells. Which disease is associated with this specific interacting gene through genomic alterations? | enterovirus infectious disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01308","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPN1 interacts with multiple genes. One of these interacting partners is supported by evidence stating that it co-immunoprecipitates with Plk1 and e... | |
medium_divergent_branch_01309 | CUL1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The hFBH1 enzyme interacted with human SKP1 and formed an SCF (SKP1/Cullin/F-box) complex together with human Cullin and ROC1.' Which protein, connected to CUL1 via this specific interaction evidence, is encoded by the gene in que... | F-box DNA helicase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01309","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The hFBH1 enzyme interacted with human SKP1 and formed an S... | |
medium_divergent_branch_01310 | NOTCH2 interacts with multiple proteins. One of these interaction partners is described in literature as a mediator through which Notch2 signals, specifically involving a transcription factor. Which protein, among the interaction partners of NOTCH2, is encoded by the gene associated with this signaling mechanism? | Recombining binding protein suppressor of hairless | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01310","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOTCH2 interacts with multiple proteins. One of these interaction partners is described in literature as a mediator through which Notch2 signals, spe... | |
medium_divergent_branch_01311 | PHF19 interacts with multiple genes. One interaction is supported by evidence stating: 'Using multiple biochemical strategies, we demonstrated that the interacting partner interacts with hPCL3 and its paralog PHF1 to form a stable complex with the PRC2 members EZH2, EED, and Suz12.' Which disease is associated with thi... | hyperparathyroidism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01311","source_qa_id":"medium_divergent_branch_04743","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PHF19 interacts with multiple genes. One interaction is supported by evidence stating: 'Using mul... | |
medium_divergent_branch_01312 | FURIN interacts with multiple proteins. One interaction partner is characterized by its ability to direct the TGN localization of FURIN through binding to the protease's phosphorylated cytosolic domain. Which protein corresponds to this description? | Phosphofurin acidic cluster sorting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01312","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FURIN interacts with multiple proteins. One interaction partner is characterized by its ability to direct the TGN localization of FURIN through bindi... | |
medium_divergent_branch_01313 | CCND1 interacts with multiple proteins. One of these interaction partners is described as directly interacting with cyclin D1 and promoting its stabilization by antagonizing ubiquitin-dependent degradation. Which protein corresponds to this description? | Ubiquitin carboxyl-terminal hydrolase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01313","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCND1 interacts with multiple proteins. One of these interaction partners is described as directly interacting with cyclin D1 and promoting its stabi... | |
medium_divergent_branch_01314 | ELK1 interacts with multiple proteins. One of these interaction partners has been shown to mediate the ubiquitination and proteasomal degradation of ELK-1 in HEK293T cells. Which protein is encoded by the gene corresponding to this specific interaction partner? | F-box only protein 25 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01314","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ELK1 interacts with multiple proteins. One of these interaction partners has been shown to mediate the ubiquitination and proteasomal degradation of ... | |
medium_divergent_branch_01315 | Pramipexole interacts with multiple drugs. One of these interacting agents is a potent inhibitor of multidrug and toxin extrusion proteins 1 (MATE1) and 2-K (MATE2-K), and evidence indicates that this agent decreases the renal clearance of pramipexole in humans. Which disease is this specific interacting drug indicated... | peptic ulcer disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01315","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Pramipexole interacts with multiple drugs. One of these interacting agents is a potent inhibitor of multidrug and toxin extrusion proteins 1 (MATE1) ... | |
medium_divergent_branch_01316 | DDX20 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating it is associated in vivo with the SMN complex through a direct interaction with Gemin3. Which protein is encoded by the gene corresponding to this specific interaction partner? | Gem-associated protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01316","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX20 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating it is associated in vivo with the SMN ... | |
medium_divergent_branch_01318 | SLC4A11 is associated with multiple molecular functions. One specific function is supported by evidence stating that SLC4A11 variants were shown to be multifunctional ion transporters capable of transporting H+ equivalents in both a Na+-independent and Na+-coupled mode. Which molecular function, connected to this speci... | monoatomic cation transmembrane transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01318","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC4A11 is associated with multiple molecular functions. One specific function is supported by evidence stating that SLC4A11 variants were shown to b... | |
medium_divergent_branch_01319 | MYCBP interacts with multiple genes. One interaction partner is described in evidence stating: 'AMY-1 has been identified by us as a c-Myc-binding protein and was found to stimulate c-Myc transcription activity.' Which disease is associated with this specific interaction partner? | cerebral infarction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01319","source_qa_id":"medium_divergent_branch_03196","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MYCBP interacts with multiple genes. One interaction partner is described in evidence stating: 'A... | |
medium_divergent_branch_01320 | PDPK1 interacts with multiple genes. One specific interaction is supported by evidence stating that PKC-zeta, PKC-delta, and PRK2 were identified as interactors of PDK1. Which disease is associated with the gene identified in this specific evidence through a biomarker relationship? | cervical squamous cell carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01320","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDPK1 interacts with multiple genes. One specific interaction is supported by evidence stating that PKC-zeta, PKC-delta, and PRK2 were identified as ... | |
medium_divergent_branch_01321 | Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.002 and an adjusted p-value of 0.0481. Which disease is associated with that selected gene? | lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01321","source_qa_id":"medium_divergent_branch_03375","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one bra... | |
medium_divergent_branch_01322 | RBBP8 interacts with multiple proteins. One of these interaction partners was identified as a binding partner for CtIP in a yeast two-hybrid screen. Which protein, encoded by the gene connected to RBBP8 via this specific interaction, is the subject of this evidence? | LIM domain transcription factor LMO4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01322","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBBP8 interacts with multiple proteins. One of these interaction partners was identified as a binding partner for CtIP in a yeast two-hybrid screen. ... | |
medium_divergent_branch_01323 | The gene CTNNBIP1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 10.32 TPM, a z-score of 2.35, and a fold enrichment of 4.37. Which cell type corresponds to this specific expression profile, and what is its immediate parent category in the cell t... | granulocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01323","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CTNNBIP1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 10.32 TPM,... | |
medium_divergent_branch_01324 | RCHY1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Here we report the identification of Pirh2, a RING-H2-type ubiquitin E3 ligase, as a novel binding partner of the cytoplasmic IF proteins keratin 8/18 (K8/18).' Which disease is associated with the gene identified in this ... | cholangiocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01324","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RCHY1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Here we report the identification of Pirh2, a RING-... | |
medium_divergent_branch_01325 | PTPN23 interacts with multiple genes. One interaction partner is described as Endofin, a FYVE-domain protein confined to endosomes, which binds to HD-PTP (an ESCRT protein that forms complexes with ESCRT-0, -I, and -III). Which cellular component is this specific interaction partner located in? | early endosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01325","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPN23 interacts with multiple genes. One interaction partner is described as Endofin, a FYVE-domain protein confined to endosomes, which binds to HD... | |
medium_divergent_branch_01326 | CUL3 interacts with multiple proteins. One specific interaction involves a partner that forms an E3 ubiquitin ligase complex with CUL3, which targets hypophosphorylated 4E-BP1. Which cellular component is this specific partner protein located in? | Cul3-RING ubiquitin ligase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01326","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL3 interacts with multiple proteins. One specific interaction involves a partner that forms an E3 ubiquitin ligase complex with CUL3, which targets... | |
medium_divergent_branch_01328 | The protein MAP1S is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'It decorates neuronal microtubules and copurifies with tubulin from brain.' Which cellular component is linked to the entity described in this evidence by the ... | microtubule cytoskeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01328","source_qa_id":"medium_divergent_branch_01425","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein MAP1S is associated with multiple cellular components via the 'located in' relationsh... | |
medium_divergent_branch_01329 | DLG1 interacts with multiple genes. One specific interaction is characterized by the following evidence: 'Here we show that upon hyperphosphorylation, hDlg interacts with the beta-TrCP ubiquitin ligase receptor through a DSGLPS motif within its Src homology 3 domain.' Identify the disease associated with the gene descr... | diabetic kidney disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01329","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLG1 interacts with multiple genes. One specific interaction is characterized by the following evidence: 'Here we show that upon hyperphosphorylation... | |
medium_divergent_branch_01330 | USP21 interacts with multiple genes. One of these interactions is characterized by a crystal structure of USP21 in complex with linear diUb aldehyde, which reveals how USP21 interacts with polyUb through a previously unidentified second Ub- and partner-binding surface on the USP domain core. Which disease is associated... | squamous cell carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01330","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP21 interacts with multiple genes. One of these interactions is characterized by a crystal structure of USP21 in complex with linear diUb aldehyde,... | |
medium_divergent_branch_01331 | RNF31 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition to known [protein]-interacting proteins, we detected SMAC/DIABLO, HTRA2/Omi, and HOIP/RNF31/PAUL/ZIBRA.' Which protein, connected to RNF31 via this interaction, is encoded by the gene in question? | Tumor necrosis factor receptor superfamily member 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01331","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF31 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition to known [protein]-interacting proteins, we de... | |
medium_divergent_branch_01332 | CCL19 is associated with multiple biological processes. One specific process is supported by evidence stating that stimulated human neutrophils migrate in response to the CCR7 ligands CCL19 and CCL21. Which cell type is linked to this specific biological process via the 'enabled by cell' relationship? | epidermal keratinocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01332","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCL19 is associated with multiple biological processes. One specific process is supported by evidence stating that stimulated human neutrophils migra... | |
medium_divergent_branch_01334 | KAT5 is associated with multiple biological processes. One association is supported by evidence stating: 'We identified the acetyltransferase KAT5 as a positive regulator of cGAS-mediated innate immune signaling.' Which biological process, connected to the process described in this evidence via a 'positively regulates'... | innate immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01334","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KAT5 is associated with multiple biological processes. One association is supported by evidence stating: 'We identified the acetyltransferase KAT5 as... | |
medium_divergent_branch_01335 | GNMT interacts with multiple proteins. One of these interaction partners was identified in a study as a novel PTEN inhibitor. Which protein, encoded by the gene corresponding to this specific interaction partner, is the target of the 'encodes' relationship? | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01335","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNMT interacts with multiple proteins. One of these interaction partners was identified in a study as a novel PTEN inhibitor. Which protein, encoded ... | |
medium_divergent_branch_01336 | FOXE3 is implicated in multiple biological processes. One specific connection is supported by evidence stating: 'In addition to the lens, most tissues of the anterior segment-iris, cornea, ciliary body and trabecular meshwork-are malformed or show differentiation defects.' Which biological process, connected to the pro... | camera-type eye development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01336","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXE3 is implicated in multiple biological processes. One specific connection is supported by evidence stating: 'In addition to the lens, most tissue... | |
medium_divergent_branch_01337 | The biological process 'regulation of gastric acid secretion' is defined as any process that modulates the rate, frequency, or extent of gastric secretion, where gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. This process is a subtype of a b... | regulation of system process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01337","source_qa_id":"medium_divergent_branch_00202","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of gastric acid secretion' is defined as any process that modu... | |
medium_divergent_branch_01338 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.253 and an adjusted p-value of 0.0393. Which protein does that selected gene encode? | WW domain-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01338","source_qa_id":"medium_divergent_branch_01226","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_01339 | The gene NTNG1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we identify human netrin-G1 ligand, a transmembrane protein containing leucine-rich repeat (LRR) and immunoglobulin (Ig) domains that specifically interacts with netrin-G1 through its LRR region.' Which pro... | Leucine-rich repeat-containing protein 4C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01339","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NTNG1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we identify human netrin-G1 ligand,... | |
medium_divergent_branch_01340 | YPEL5 interacts with multiple genes. One of these interacting partners is a paralog of RanBPM that was identified as a YPEL5-binding protein, with the two protein genes showing high conservation. Which protein is encoded by this specific interacting gene? | Ran-binding protein 10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01340","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"YPEL5 interacts with multiple genes. One of these interacting partners is a paralog of RanBPM that was identified as a YPEL5-binding protein, with th... | |
medium_divergent_branch_01341 | EFHC1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating that immunoprecipitation analysis demonstrates the physical interaction of the N- and C-terminal cytoplasmic regions of this partner with the EFHC1 protein. Which protein is this interaction partner? | Transient receptor potential cation channel subfamily M member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01341","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EFHC1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating that immunoprecipitation analysis demonstr... | |
medium_divergent_branch_01342 | TRIM72 interacts with multiple genes. One of these interaction partners is described in evidence stating: 'The focal adhesion kinase protein was associated with the E2 enzyme UBE2H and the E3 enzyme MG53 in endogenous and exogenous immunoprecipitation experiments.' Which disease is causally linked to this interaction p... | brain neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01342","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM72 interacts with multiple genes. One of these interaction partners is described in evidence stating: 'The focal adhesion kinase protein was asso... | |
medium_divergent_branch_01343 | CDKN1A interacts with multiple genes. One interaction is supported by evidence stating: 'We have identified a tetratricopeptide repeat (TPR) protein that binds p21.' Which disease is associated with the gene identified in this evidence via a biomarker relationship? | azoospermia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01343","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDKN1A interacts with multiple genes. One interaction is supported by evidence stating: 'We have identified a tetratricopeptide repeat (TPR) protein ... | |
medium_divergent_branch_01345 | FNBP1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'When overexpressed, CD95L co-precipitates with FBP17 and PACSIN.' Which protein is encoded by the gene connected to FNBP1 via this specific interaction? | Tumor necrosis factor ligand superfamily member 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01345","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FNBP1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'When overexpressed, CD95L co-precipitates with FBP1... | |
medium_divergent_branch_01346 | GATA4 physically interacts with multiple proteins. One specific interaction is described as follows: 'FOG-2 associates physically with the N-terminal zinc finger of GATA-4 both in vitro and in vivo.' Which protein is encoded by the gene corresponding to this interacting partner? | Zinc finger protein ZFPM2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01346","source_qa_id":"medium_divergent_branch_05116","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GATA4 physically interacts with multiple proteins. One specific interaction is described as follo... | |
medium_divergent_branch_01347 | PEG3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Although it is not clear whether the induction of Pw1/Peg3 depends on p53 activity, we show that Pw1/Peg3 interacts with a p53-inducible gene product Siah1a.' Which protein, connected to PEG3 via an interaction, is encoded by the ... | E3 ubiquitin-protein ligase SIAH2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01347","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PEG3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Although it is not clear whether the induction of Pw1/Peg3 ... | |
medium_divergent_branch_01348 | ROR1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence describing ROR1 as a tyrosine kinase-like receptor localized at a particular membrane structure. Which cellular component is connected to this specific location through the 'part of'... | cell periphery | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01348","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ROR1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence describing ... | |
medium_divergent_branch_01349 | SLC38A9 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence describing SLC38A9 as a poorly understood protein. Which cellular component, connected to the selected component via the 'is a' relationship, corresponds to this evidence? | lytic vacuole membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01349","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC38A9 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence describ... | |
medium_divergent_branch_01350 | TRIM31 interacts with multiple proteins. One of these interaction partners is directly bound by TRIM31, which promotes its K48-linked polyubiquitination and subsequent proteasomal degradation. Which protein corresponds to this interaction partner? | NACHT, LRR and PYD domains-containing protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01350","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM31 interacts with multiple proteins. One of these interaction partners is directly bound by TRIM31, which promotes its K48-linked polyubiquitinat... | |
medium_divergent_branch_01351 | MYC interacts with multiple proteins. One interaction involves a protein that binds to the c-MYC oncoprotein, where its stimulatory effect on the hTERT promoter is significantly dependent on functional E-boxes in the promoter. Which disease is associated with this interacting protein as a biomarker? | Fanconi anemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01351","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYC interacts with multiple proteins. One interaction involves a protein that binds to the c-MYC oncoprotein, where its stimulatory effect on the hTE... | |
medium_divergent_branch_01352 | Calcipotriol (topical) interacts with multiple agents. One interaction is supported by evidence showing that Oxacalcitriol caused a maximal 44% decrease in PTH mRNA levels at 2 and 5 nmol, an effect comparable to that of 1 nmol calcipotriol. Which disease is the drug identified by this evidence indicated for? | osteoporosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01352","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Calcipotriol (topical) interacts with multiple agents. One interaction is supported by evidence showing that Oxacalcitriol caused a maximal 44% decre... | |
medium_divergent_branch_01354 | NRG1 is implicated in multiple biological processes. One specific process is characterized by evidence stating that NRG1 has essential functions in the development of neural crest cells and some of their major derivatives, such as Schwann cells and sympathetic neurons. Which biological process is a part of the process ... | neural crest cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01354","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NRG1 is implicated in multiple biological processes. One specific process is characterized by evidence stating that NRG1 has essential functions in t... | |
medium_divergent_branch_01356 | USP25 interacts with multiple genes. One of these interaction partners is reported to associate with three sarcomeric proteins: actin alpha-1, filamin C (FLNC), and a myosin binding protein, which are critical for muscle differentiation and maintenance and are implicated in severe myopathies. Which cellular component i... | myofibril | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01356","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP25 interacts with multiple genes. One of these interaction partners is reported to associate with three sarcomeric proteins: actin alpha-1, filami... | |
medium_divergent_branch_01357 | RNPS1 interacts with multiple proteins. One of these interaction partners is stabilized by RNPS1, which inhibits its ubiquitination-mediated degradation by the E3 ubiquitin ligase ZSWIM6 through direct protein interaction, thereby promoting high expression of this partner in head and neck squamous cell carcinoma (HNSCC... | RNA cytidine acetyltransferase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01357","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNPS1 interacts with multiple proteins. One of these interaction partners is stabilized by RNPS1, which inhibits its ubiquitination-mediated degradat... | |
medium_divergent_branch_01358 | ABCA3 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'The protein folds in endoplasmic reticulum and is glycosylated in Golgi en route to the membrane of mature LB and their precursor multivesicular bodies (MVB).' Which cellu... | lamellar body | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01358","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCA3 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: '... | |
medium_divergent_branch_01359 | PSMD11 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we demonstrated that HsDSS1 regulates the human proteasome by associating with it in the cytosol and nucleus via the RPN3/S3 subunit of the 19S regulatory particle (RP).' Identify the disease associated with the gene implicat... | extragonadal germ cell tumor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01359","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMD11 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we demonstrated that HsDSS1 regulates the human protea... | |
medium_divergent_branch_01360 | The gene CDKN1B interacts with multiple partners. One specific interaction is supported by evidence stating: 'One of the proteins isolated was p27; this novel interaction was confirmed both in vitro, using bacterially expressed and in vitro translated proteins, and in vivo, through the examination of endogenous and tra... | Speedy protein A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01360","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CDKN1B interacts with multiple partners. One specific interaction is supported by evidence stating: 'One of the proteins isolated was p27; t... |
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