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medium_divergent_branch_01361 | Vimentin (VIM) interacts with multiple proteins. One interaction is supported by evidence describing gain-of-function and rescue experiments in vitro and in vivo, which evaluated the suppressive effects of circNR3C2 on breast cancer progression through the proteasomal degradation of Vimentin mediated by an E3 ubiquitin... | E3 ubiquitin-protein ligase synoviolin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01361","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Vimentin (VIM) interacts with multiple proteins. One interaction is supported by evidence describing gain-of-function and rescue experiments in vitro... | |
medium_divergent_branch_01362 | The insulin receptor (INSR) interacts with multiple genes. One specific interaction is supported by evidence showing that insulin stimulation causes selective coprecipitation of PKC delta with IR, accompanied by a striking induction of PKC activity specifically attributable to PKC delta. Which disease is associated wit... | cervical squamous cell carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01362","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The insulin receptor (INSR) interacts with multiple genes. One specific interaction is supported by evidence showing that insulin stimulation causes ... | |
medium_divergent_branch_01363 | The gene IL2RB is known to interact with multiple proteins. One specific interaction partner is characterized by evidence stating that it, along with another kinase, was found to be selectively associated with the 'serine-rich' region of IL-2R beta and the carboxyl-terminal region of IL-2R gamma, respectively. Which pr... | Tyrosine-protein kinase JAK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01363","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL2RB is known to interact with multiple proteins. One specific interaction partner is characterized by evidence stating that it, along with... | |
medium_divergent_branch_01364 | SIGMAR1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Mechanistically, the protein encoded by the gene in question was identified to interact with Sigmar1 based on the immunoprecipitation-mass spectrum (IP-MS) and co-immunoprecipitation (co-IP) assays, and Q615 of this pr... | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01364","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIGMAR1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Mechanistically, the protein encoded by the gen... | |
medium_divergent_branch_01365 | ATG7 interacts with multiple genes. One interaction is supported by evidence stating: 'Each of three human Apg8p counterparts, i.e. the Golgi-associated ATPase enhancer of 16 kDa, GABA(A) receptor-associated protein, and microtubule-associated protein light chain 3, coimmunoprecipitates with hApg7p and conjugates with ... | hyperphosphatemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01365","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATG7 interacts with multiple genes. One interaction is supported by evidence stating: 'Each of three human Apg8p counterparts, i.e. the Golgi-associa... | |
medium_divergent_branch_01366 | FOXO4 interacts with multiple proteins. One of these interactions is characterized by the following evidence: 'Consistent with this, oxidative stress induces binding of the interaction partner to FOXO, thereby attenuating its monoubiquitination, a yet uncharacterized mode of substrate modulation by the interaction part... | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01366","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXO4 interacts with multiple proteins. One of these interactions is characterized by the following evidence: 'Consistent with this, oxidative stress... | |
medium_divergent_branch_01367 | The gene NGFR interacts with multiple partners via binding. One specific interaction partner is implicated in a study showing that its binding to p75(NTR), alongside TRAF2 and TRAF4, modulates p75(NTR)-induced cell death and NF-kappaB activation with contrasting effects. Which disease is associated with this specific i... | bone resorption disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01367","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NGFR interacts with multiple partners via binding. One specific interaction partner is implicated in a study showing that its binding to p75... | |
medium_divergent_branch_01369 | Juxtacanalicular tissue cells are a specific subtype of cell found within the eye's drainage system. Evidence indicates that this cell type is characterized by a spindle-shaped, fibroblast-like morphology within a loose extracellular matrix immediately adjacent to Schlemm's canal. It expresses CHI3L1 and ANGPTL7, as we... | eye trabecular meshwork | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01369","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Juxtacanalicular tissue cells are a specific subtype of cell found within the eye's drainage system. Evidence indicates that this cell type is charac... | |
medium_divergent_branch_01370 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.320 and an adjusted p-value of 0.0459. Which disease has a genomic-alteration link with that selected gene? | Aicardi-Goutieres syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01370","source_qa_id":"medium_divergent_branch_02839","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_01372 | Epicardial fat is classified as a type of two different anatomical structures. One of these classifications is supported by evidence describing visceral intrapericardial fat as being contiguous with the myocardial surface. Which anatomical structure is the parent class of epicardial fat in this specific context? | visceral fat | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01372","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Epicardial fat is classified as a type of two different anatomical structures. One of these classifications is supported by evidence describing visce... | |
medium_divergent_branch_01373 | RAB21 interacts with multiple genes. One interaction partner is described as an actin and microtubule regulator that binds to activated RAB21-GTP and serves as a partner of GolginA4. Which disease is associated with this specific interaction partner? | lissencephaly 9 with complex brainstem malformation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01373","source_qa_id":"medium_divergent_branch_04096","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RAB21 interacts with multiple genes. One interaction partner is described as an actin and microtu... | |
medium_divergent_branch_01374 | TRAF6 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'Interaction of TRAF6 with [the protein encoded by the gene linked to TRAF6 via this specific interaction] involves direct contacts of the RING and the preceding residues, and the first zinc finger has a structu... | Ubiquitin-conjugating enzyme E2 N | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01374","source_qa_id":"medium_divergent_branch_01570","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"TRAF6 interacts with multiple proteins. One specific interaction is characterized by the followin... | |
medium_divergent_branch_01375 | LGALS1 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'Direct interaction between the protein and galectin-1 was demonstrated in glutathione S-transferase (GST) pull-down assays.' What is the name of the protein encoded by the gene that is the subject of this specific expe... | Gem-associated protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01375","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LGALS1 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'Direct interaction between the protein and gale... | |
medium_divergent_branch_01376 | The intervertebral disk of the cervical vertebra is a type of anatomy that connects to a broader anatomical structure via a 'part of' relationship. Evidence for this connection describes the entity as an intervertebral disk that is part of a cervical region of the vertebral column, connecting at least one cervical vert... | postcranial axial skeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01376","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The intervertebral disk of the cervical vertebra is a type of anatomy that connects to a broader anatomical structure via a 'part of' relationship. E... | |
medium_divergent_branch_01377 | DDX39A interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation and mass spectrometry analyses detected a recently discovered growth and cell cycle-related factor, as a main DDX39-interacting protein.' Which protein product is encoded by the gene corresponding... | SAP domain-containing ribonucleoprotein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01377","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX39A interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation and mass spectrometry ana... | |
medium_divergent_branch_01380 | MEF2A interacts with multiple genes. One of these interaction partners is characterized by evidence stating that a point mutation in HDAC7, which disrupts its association with MEF2A, also disrupts its association with alpha-actinin 4, indicating that the binding sites for MEF2A and alpha-actinin 4 largely overlap. Whic... | cerebellar hemangioblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01380","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEF2A interacts with multiple genes. One of these interaction partners is characterized by evidence stating that a point mutation in HDAC7, which dis... | |
medium_divergent_branch_01381 | CDC7 interacts with multiple proteins. One interaction is supported by evidence stating: 'A novel human protein, [activator of S phase kinase], was identified on the basis of its ability to bind to human Cdc7-related kinase (huCdc7).' Which protein, connected to CDC7 via a binding interaction, is the subject of this sp... | Protein DBF4 homolog A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01381","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDC7 interacts with multiple proteins. One interaction is supported by evidence stating: 'A novel human protein, [activator of S phase kinase], was i... | |
medium_divergent_branch_01382 | CSNK1E interacts with multiple genes. One interaction is characterized by the phosphorylation of a phosphodegron in a specific protein by LATS, which primes it for further phosphorylation by CK1ε and subsequent binding by β-TrCP. Which disease is associated with this specific interacting partner via a biomarker relatio... | hepatocellular carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01382","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CSNK1E interacts with multiple genes. One interaction is characterized by the phosphorylation of a phosphodegron in a specific protein by LATS, which... | |
medium_divergent_branch_01384 | RAD18 interacts with multiple genes. One of these interaction partners functions as an adaptor to facilitate homologous recombination through direct interaction with the recombinase RAD51C. Which disease is causally linked to this specific interaction partner? | hypersensitivity reaction disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01384","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD18 interacts with multiple genes. One of these interaction partners functions as an adaptor to facilitate homologous recombination through direct ... | |
medium_divergent_branch_01385 | ITGA1 interacts with multiple genes. One interaction is supported by evidence stating: 'In these cells beta 1B represent integral of 30% of the beta 1 and form heterodimers with alpha 1 and alpha 5 subunits.' Which disease is associated with the gene described in this evidence? | hyperthyroidism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01385","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGA1 interacts with multiple genes. One interaction is supported by evidence stating: 'In these cells beta 1B represent integral of 30% of the beta ... | |
medium_divergent_branch_01386 | CDT1 interacts with multiple proteins. One interaction is described by the following evidence: 'This poly-ubiquitination of Geminin prevents DNA replication over-firing by indirectly blocking the association of Cdt1 with the MCM protein complex, an interaction required for DNA unwinding and replication.' Which protein,... | DNA replication licensing factor MCM2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01386","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDT1 interacts with multiple proteins. One interaction is described by the following evidence: 'This poly-ubiquitination of Geminin prevents DNA repl... | |
medium_divergent_branch_01387 | The FLCN gene interacts with multiple partners. One interaction is supported by evidence stating: 'Here we show that the tumour suppressor FLCN is a [chaperone] client protein and its binding partners FNIP1/FNIP2 function as co-chaperones.' Which protein is encoded by the gene that interacts with FLCN in this specific ... | Heat shock protein HSP 90-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01387","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The FLCN gene interacts with multiple partners. One interaction is supported by evidence stating: 'Here we show that the tumour suppressor FLCN is a ... | |
medium_divergent_branch_01389 | SP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Indeed, mammalian two-hybrid assays, GST fusion protein pull-down assays, and co-immunoprecipitation assays showed that Sp1ZFDBD and Sp1ID are able to interact with corepressor proteins such as SMRT, NcoR, and BCoR.' Which disease is ... | glioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01389","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Indeed, mammalian two-hybrid assays, GST fusion protein pull-do... | |
medium_divergent_branch_01390 | ARL4A interacts with multiple proteins. One interaction is supported by evidence stating: 'Both methods converged on Arl4A, an Arf-related GTPase, as a specific ELMO interactor.' Which protein, connected to ARL4A via this interaction, is encoded by the gene in question? | Engulfment and cell motility protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01390","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARL4A interacts with multiple proteins. One interaction is supported by evidence stating: 'Both methods converged on Arl4A, an Arf-related GTPase, as... | |
medium_divergent_branch_01391 | SMAD7 is associated with multiple biological processes. One association is supported by evidence stating that SMAD7, an inhibitory Smad and downstream signaling molecule of TGF-β1, represses epithelial-to-mesenchymal transition (EMT). Which biological process, connected to the process described by this evidence via an ... | regulation of cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01391","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD7 is associated with multiple biological processes. One association is supported by evidence stating that SMAD7, an inhibitory Smad and downstrea... | |
medium_divergent_branch_01392 | MAML3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Moreover, as determined by using coimmunoprecipitation assays, each MAML protein was found to be capable of forming a multiprotein complex with the intracellular domain of each Notch receptor (ICN1 to -4) and CSL in vivo.' ... | diabetic kidney disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01392","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAML3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Moreover, as determined by using coimmunoprecipitati... | |
medium_divergent_branch_01393 | ATG4B interacts with multiple genes. One of these interactions is supported by evidence stating: 'We solved the crystal structures of the [gene]-ATG4B C-terminal LIR complex.' Which disease is associated with this specific interacting gene via a biomarker relationship? | Diamond-Blackfan anemia 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01393","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATG4B interacts with multiple genes. One of these interactions is supported by evidence stating: 'We solved the crystal structures of the [gene]-ATG4... | |
medium_divergent_branch_01394 | The COPA protein interacts with multiple partners. One specific interaction is supported by evidence identifying members of the coatomer I (COPI) complex as interaction partners of hSAC1. Which biological process is the gene corresponding to this specific interaction partner involved in? | phosphatidylinositol dephosphorylation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01394","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The COPA protein interacts with multiple partners. One specific interaction is supported by evidence identifying members of the coatomer I (COPI) com... | |
medium_divergent_branch_01396 | IGBP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using the yeast two-hybrid system, we have found that alpha 4, a previously identified phosphoprotein, associates constitutively with the catalytic subunits of [Protein A], PP6, and both isoforms of PP2A.' Which protein, encoded ... | Serine/threonine-protein phosphatase 4 catalytic subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01396","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGBP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using the yeast two-hybrid system, we have found that alph... | |
medium_divergent_branch_01397 | EP400 interacts with multiple proteins. One interaction is supported by evidence describing a native complex containing MRG15, BRD8, EP400NL, and the protein in question, which is functionally similar to the yeast TINTIN complex. Which protein is this? | MRG/MORF4L-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01397","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EP400 interacts with multiple proteins. One interaction is supported by evidence describing a native complex containing MRG15, BRD8, EP400NL, and the... | |
medium_divergent_branch_01398 | RPSA interacts with multiple genes. One of these interacting partners binds to RPSA via its FHA domain. Furthermore, knockdown of RPSA leads to the depletion of this partner and BRCA1 from the nucleolus, indicating that the interaction is essential for the nucleolar localization of these DNA damage response factors. Wh... | Fanconi anemia complementation group A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01398","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPSA interacts with multiple genes. One of these interacting partners binds to RPSA via its FHA domain. Furthermore, knockdown of RPSA leads to the d... | |
medium_divergent_branch_01399 | The gene TAFAZZIN is associated with multiple proteins via interaction relationships. One specific interaction is supported by the following evidence: 'In this study, we identified that the protein directly interacts with Transcriptional Co-Activator With PDZ-Binding Motif (TAZ) in OS cell lines.' Which protein corresp... | Ubiquitin carboxyl-terminal hydrolase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01399","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TAFAZZIN is associated with multiple proteins via interaction relationships. One specific interaction is supported by the following evidence... | |
medium_divergent_branch_01400 | NCOR1 interacts with multiple proteins. One specific interaction is supported by evidence that a specific protein directly binds to the N-terminal region of N-CoR via a small N-CoR interaction domain (NID) in both in vitro and in vivo settings. Which protein corresponds to this specific interaction partner? | Lysine-specific demethylase 4A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01400","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOR1 interacts with multiple proteins. One specific interaction is supported by evidence that a specific protein directly binds to the N-terminal re... | |
medium_divergent_branch_01401 | AMER1 interacts with multiple genes. One interaction is supported by evidence stating: 'This assay revealed that WTX, a protein encoded by a gene mutated in Wilms tumors, forms a complex with beta-catenin, AXIN1, beta-TrCP2 (beta-transducin repeat-containing protein 2), and APC (adenomatous polyposis coli).' Identify t... | neurodevelopmental, jaw, eye, and digital syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01401","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMER1 interacts with multiple genes. One interaction is supported by evidence stating: 'This assay revealed that WTX, a protein encoded by a gene mut... | |
medium_divergent_branch_01402 | The gene GRM2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Follow-up co-immunoprecipitation studies demonstrated that both mGluR2 and mGluR3 can associate with NHERF-1 and a second protein in a cellular context.' Which protein, connected to GRM2 via this specific interaction evid... | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01402","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GRM2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Follow-up co-immunoprecipitation studies demonstra... | |
medium_divergent_branch_01403 | VAV1 interacts with multiple proteins. One specific interaction partner is described as a zinc finger protein, which binds to both Vav-1 and cyclin-dependent kinase 4 through two independent domains. This partner corresponds to a Vav C-Src homology domain (SH)3 partner capable of shuttling between the nucleus and the c... | Zinc finger protein 655 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01403","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VAV1 interacts with multiple proteins. One specific interaction partner is described as a zinc finger protein, which binds to both Vav-1 and cyclin-d... | |
medium_divergent_branch_01405 | MAPK14 interacts with multiple genes. One interaction is supported by evidence stating: 'Immunoprecipitation and glutathione S-transferase (GST) pull-down studies showed that Akt was associated with p38 kinase, a MAPKAPK2 family member, and Hsp27 in neutrophils, and Hsp27 dissociated from the complex upon activation.' ... | Alzheimer disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01405","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK14 interacts with multiple genes. One interaction is supported by evidence stating: 'Immunoprecipitation and glutathione S-transferase (GST) pull... | |
medium_divergent_branch_01406 | ADAM17 interacts with multiple proteins. One of these interaction partners is described in mechanistic studies as binding directly to ADAM17 and being identified as E3 ubiquitin ligase tripartite motif-containing protein 47. Which gene encodes this specific interaction partner? | E3 ubiquitin-protein ligase TRIM47 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01406","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAM17 interacts with multiple proteins. One of these interaction partners is described in mechanistic studies as binding directly to ADAM17 and bein... | |
medium_divergent_branch_01407 | FBXL5 interacts with multiple proteins. One of these interaction partners is described as targeting a specific protein for ubiquitination and degradation, a process that can be prevented by ATM-mediated phosphorylation of that protein at threonine 117. Which protein, encoded by the gene connected to FBXL5 via this spec... | SOSS complex subunit B1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01407","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXL5 interacts with multiple proteins. One of these interaction partners is described as targeting a specific protein for ubiquitination and degrada... | |
medium_divergent_branch_01408 | FKBP4 interacts with multiple genes. One of these interaction partners is described in a study stating: 'Using glutathione-S transferase pull-down assays and immunoprecipitation, we have demonstrated that S100A1 and this gene specifically interact with the TPR domains of FKBP52 and CyP40 in a Ca(2+)-dependent manner, a... | endothelial cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01408","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FKBP4 interacts with multiple genes. One of these interaction partners is described in a study stating: 'Using glutathione-S transferase pull-down as... | |
medium_divergent_branch_01409 | CHMP4B interacts with multiple genes. One of these interacting partners was identified in a yeast two-hybrid assay where a protein tyrosine phosphatase showed positive interactions with it, along with TSG101, endophilin A1, and ALG-2, but not with RabGAPLP or CIN85. Which disease is associated with this specific intera... | mammary neoplasms, animal | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01409","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHMP4B interacts with multiple genes. One of these interacting partners was identified in a yeast two-hybrid assay where a protein tyrosine phosphata... | |
medium_divergent_branch_01410 | EIF2AK2 interacts with multiple genes. One interaction is supported by evidence stating: 'To understand the basis for substrate recognition by and the regulation of PKR, we determined X-ray crystal structures of the catalytic domain of PKR in complex with eIF2alpha.' Which protein is encoded by the gene connected to EI... | Eukaryotic translation initiation factor 2A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01410","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF2AK2 interacts with multiple genes. One interaction is supported by evidence stating: 'To understand the basis for substrate recognition by and th... | |
medium_divergent_branch_01411 | EIF2AK2 interacts with multiple genes. One interaction is supported by evidence stating: 'We also show that PKR associates with this gene in mouse and human cells.' Which disease is associated with this gene through genomic alterations? | esophageal candidiasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01411","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF2AK2 interacts with multiple genes. One interaction is supported by evidence stating: 'We also show that PKR associates with this gene in mouse an... | |
medium_divergent_branch_01413 | KMT5A (also known as SETD8) interacts with multiple proteins. One specific interaction is characterized by evidence stating that KMT5A is a newly identified substrate of the interacting partner in both in vitro and in vivo settings. Which protein corresponds to this interacting partner? | E3 ubiquitin-protein ligase RNF8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01413","source_qa_id":"medium_divergent_branch_01798","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"KMT5A (also known as SETD8) interacts with multiple proteins. One specific interaction is charact... | |
medium_divergent_branch_01414 | Human respirovirus 3 upregulates multiple genes. One such gene exhibits a log2 fold change of approximately 2.215 and an adjusted p-value of 0.04216 in non-small cell lung adenocarcinoma cells. In which cell type is this specific gene enriched? | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01414","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human respirovirus 3 upregulates multiple genes. One such gene exhibits a log2 fold change of approximately 2.215 and an adjusted p-value of 0.04216 ... | |
medium_divergent_branch_01415 | DLG4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Two of these proteins, brain-specific angiogenesis inhibitor 1 and protein kinase Calpha, co-immunoprecipitated with PSD-95 and SAP102 from rat brain extracts.' Which protein, connected to DLG4 via this specific interaction eviden... | Adhesion G protein-coupled receptor B1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01415","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLG4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Two of these proteins, brain-specific angiogenesis inhibito... | |
medium_divergent_branch_01417 | GNB5 interacts with multiple proteins. One interaction is supported by evidence stating: 'We observed that Gbeta5 could interact with Ggamma2 and Ggamma13, after their expression in human embryonic kidney 293 cells.' Which protein, among those interacting with GNB5, is encoded by the gene corresponding to the interacti... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01417","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNB5 interacts with multiple proteins. One interaction is supported by evidence stating: 'We observed that Gbeta5 could interact with Ggamma2 and Gga... | |
medium_divergent_branch_01418 | hsa-miR-182-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'Further work revealed that functional miR-92a-3p, miR-21-5p, miR-16-5p, miR-126 and miR-182-5p in MVs could be delivered into T cells to induce the exhaustion phenotype.' Which cell type, connected to hsa-miR-182... | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01418","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-182-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'Further work revealed that functional miR... | |
medium_divergent_branch_01419 | RUNX1 interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'In addition, one of these SUV39H1-binding motifs is also sufficient for binding to histone deacetylases 1 and 3, and both of these domains are required for full RUNX1-mediated transcriptional repression.' ... | Histone deacetylase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01419","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RUNX1 interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'In addition, one of these SUV39H1-... | |
medium_divergent_branch_01420 | AGPS interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation confirmed that the two enzymes interact, in a heterotrimeric complex.' Which disease is associated with the gene involved in this specific interaction via genomic alterations? | rhizomelic chondrodysplasia punctata type 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01420","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AGPS interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation confirmed that the two enzy... | |
medium_divergent_branch_01421 | EIF2B5 is implicated in multiple biological processes. One specific connection is supported by evidence that RNAi-mediated knockdown of EIF2B5 severely compromises the induction of GFAP-positive cells from normal human glial progenitors. Which biological process, connected to the process supported by this evidence via ... | central nervous system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01421","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF2B5 is implicated in multiple biological processes. One specific connection is supported by evidence that RNAi-mediated knockdown of EIF2B5 severe... | |
medium_divergent_branch_01422 | The vestibular ganglion is anatomically connected to a larger structure via a 'part of' relationship. Contextual evidence describes the ganglion as containing the cell bodies of bipolar primary afferent neurons that synapse with hair cells in the vestibular sensory end organs, specifically distributed to the maculae of... | vestibulo-auditory system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01422","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The vestibular ganglion is anatomically connected to a larger structure via a 'part of' relationship. Contextual evidence describes the ganglion as c... | |
medium_divergent_branch_01423 | OTUB1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we demonstrate that a lysine monomethylase, directly interacts with OTUB1 to catalyze OTUB1 methylation at lysine 122.' Which disease is associated with the gene identified by this evidence? | infectious mononucleosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01423","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OTUB1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we demonstrate that a lysine monomethylase, di... | |
medium_divergent_branch_01424 | TP63 interacts with multiple genes. One specific interaction is supported by evidence that SCF(betaTrCP1) binds to p63gamma isoforms, exhibiting higher affinity for the TAp63gamma isoform. Which disease is associated with the gene encoding the substrate recognition subunit of this SCF complex via a biomarker relationsh... | diabetic kidney disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01424","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TP63 interacts with multiple genes. One specific interaction is supported by evidence that SCF(betaTrCP1) binds to p63gamma isoforms, exhibiting high... | |
medium_divergent_branch_01425 | GOLPH3 is associated with multiple biological processes. One association is supported by evidence stating that GOLPH3 acts as a phosphatidylinositol-4-phosphate (PI4P) effector crucial for maintaining Golgi architecture and anterograde trafficking. Identify the parent biological process (via an 'is a' relationship) of ... | organelle organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01425","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GOLPH3 is associated with multiple biological processes. One association is supported by evidence stating that GOLPH3 acts as a phosphatidylinositol-... | |
medium_divergent_branch_01426 | MAVS interacts with multiple proteins. One interaction is supported by evidence stating: 'We identify the mitochondrial antiviral-signalling protein (MAVS) as an endogenous TA client of both [Candidate Protein] and the BAG6 complex.' Which disease is associated with this specific candidate protein? | alcohol abuse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01426","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAVS interacts with multiple proteins. One interaction is supported by evidence stating: 'We identify the mitochondrial antiviral-signalling protein ... | |
medium_divergent_branch_01427 | NAP1L1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that a protein, known to harbor characteristics of a corepressor of nuclear hormone receptors such as of the vitamin D receptor (VDR), binds in vivo and in vitro to NAP1 and modulates its activity by enhancing NAP1... | COP9 signalosome complex subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01427","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NAP1L1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that a protein, known to harbor characteris... | |
medium_divergent_branch_01428 | The protein NUMA1 is associated with multiple biological processes. One association is supported by evidence describing NuMA as a large nuclear protein required for spindle organization. Which biological process is a parent term (via an 'is a' relationship) of the process linked to NUMA1 by this specific evidence? | microtubule cytoskeleton organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01428","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein NUMA1 is associated with multiple biological processes. One association is supported by evidence describing NuMA as a large nuclear prote... | |
medium_divergent_branch_01431 | GPR15 is associated with multiple molecular functions. One of these functions is supported by evidence describing GPR15 as an orphan G protein-coupled receptor (GPCR) found in lymphocytes. Which molecular function, connected to this specific function via an 'is a' relationship, represents the broader category? | transmembrane signaling receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01431","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPR15 is associated with multiple molecular functions. One of these functions is supported by evidence describing GPR15 as an orphan G protein-couple... | |
medium_divergent_branch_01432 | The gene NFKB2 is known to interact with multiple partners. One specific interaction partner is described by the following evidence: 'I kappaB epsilon interacts with different NF-kappaB proteins, including p65, c-Rel, p50, and p52, in vitro and in vivo and inhibits the DNA-binding activity of both p50-p65 and p50-c-Rel... | periodontitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01432","source_qa_id":"medium_divergent_branch_06279","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene NFKB2 is known to interact with multiple partners. One specific interaction partner is d... | |
medium_divergent_branch_01433 | The gene AGTR2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In the present study, we report the molecular cloning of a novel protein, [REDACTED] (AT2-interacting protein), which interacts with the C-terminal tail of the AT2 receptor, but not with those of other receptors... | Microtubule-associated tumor suppressor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01433","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AGTR2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In the present study, we report the mole... | |
medium_divergent_branch_01434 | UBE2A interacts with multiple proteins. One of these interaction partners was identified as a binding partner using yeast two-hybrid analysis and confirmed via immunoprecipitation studies. Which protein product is encoded by the gene corresponding to this specific interaction partner? | Zinc finger MYM-type protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01434","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2A interacts with multiple proteins. One of these interaction partners was identified as a binding partner using yeast two-hybrid analysis and con... | |
medium_divergent_branch_01435 | RNF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'The interaction of Hip-2 with RNF2, one of the clones, was further confirmed through in vitro and in vivo experiments.' Which protein product is encoded by the gene corresponding to this interacting partner? | Ubiquitin-conjugating enzyme E2 D2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01435","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'The interaction of Hip-2 with RNF2, one of the clones, was ... | |
medium_divergent_branch_01436 | The gene CLCN1 interacts with multiple proteins. One specific interaction partner is described in a study where it, along with c-Jun, chloride channel protein CLC-1, transcription factor IKZF1, and MEIS2, was used as a model to investigate the effects of immunomodulatory drugs (IMiDs) such as thalidomide, lenalidomide,... | Protein cereblon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01436","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CLCN1 interacts with multiple proteins. One specific interaction partner is described in a study where it, along with c-Jun, chloride channe... | |
medium_divergent_branch_01437 | CUL2 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'We show that the interaction with cullins is independent of ubiquitin- and substrate-binding. Instead, it relies on the UIM motif in the interacting protein that directly engages the NEDD8 modification on cullin... | proteasome-mediated ubiquitin-dependent protein catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01437","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL2 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'We show that the interaction with cullin... | |
medium_divergent_branch_01438 | AGO2 is known to bind multiple proteins. One specific interaction is supported by evidence stating: 'We show that a specific importin beta family member interacts with Ago proteins and localizes to cytoplasmic processing bodies (P bodies), structures involved in RNA metabolism.' Which protein is encoded by the gene cor... | Importin-8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01438","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AGO2 is known to bind multiple proteins. One specific interaction is supported by evidence stating: 'We show that a specific importin beta family mem... | |
medium_divergent_branch_01440 | SORBS1 interacts with multiple proteins. One of these interaction partners was identified using the yeast two-hybrid system, and its binding to SORBS1 was confirmed by in vitro pull-down experiments, nuclear colocalization, and co-immunoprecipitation assays. Specifically, the evidence highlights the interaction with Cb... | glucagonoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01440","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SORBS1 interacts with multiple proteins. One of these interaction partners was identified using the yeast two-hybrid system, and its binding to SORBS... | |
medium_divergent_branch_01441 | The gene NONO interacts with multiple other genes. One of these interaction partners is supported by evidence stating: 'We identified a heterodimer, p54nrb and PSF, as its binding partners and confirmed their physical interaction in vivo by the co-immunoprecipitation experiment.' Which protein is encoded by the gene co... | E3 ubiquitin-protein ligase RNF43 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01441","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NONO interacts with multiple other genes. One of these interaction partners is supported by evidence stating: 'We identified a heterodimer, ... | |
medium_divergent_branch_01442 | MAP1LC3B interacts with multiple proteins. One of these interaction partners is described as being recruited to isolation membranes and autophagosomes through direct interaction with Atg8 homologues, and it participates in the fusion between autophagosomes and lysosomes via its GAP activity. Which biological process is... | regulation of autophagosome maturation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01442","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP1LC3B interacts with multiple proteins. One of these interaction partners is described as being recruited to isolation membranes and autophagosome... | |
medium_divergent_branch_01443 | The APC protein interacts with multiple partners. One specific interaction partner is characterized by in vivo association with CtBP and in vitro binding to CtBP mediated by conserved 15-amino acid repeats. Which disease is linked to this specific interaction partner via a biomarker relationship? | osteosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01443","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The APC protein interacts with multiple partners. One specific interaction partner is characterized by in vivo association with CtBP and in vitro bin... | |
medium_divergent_branch_01444 | The gene SET interacts with multiple partners. One interaction is supported by evidence stating: 'Our detailed characterization showed that the SET protein formed a complex with Cdk5/[protein encoded by the interacting gene] through its binding to [protein encoded by the interacting gene].' Which protein is encoded by ... | Cyclin-dependent kinase 5 activator 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01444","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SET interacts with multiple partners. One interaction is supported by evidence stating: 'Our detailed characterization showed that the SET p... | |
medium_divergent_branch_01445 | TGM1 is associated with multiple biological processes. One association is supported by evidence showing that HaCaT cells transfected with mutant TGM1 cDNAs exhibited a lower growth rate and delayed S phase, whereas overexpression of wild-type TGM1 cDNAs resulted in accelerated growth. Which biological process, connecte... | keratinocyte proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01445","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TGM1 is associated with multiple biological processes. One association is supported by evidence showing that HaCaT cells transfected with mutant TGM1... | |
medium_divergent_branch_01446 | PIAS4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Both d-flow and ONOO(-) increased the association of PKCζ with protein inhibitor of activated STATy (PIASy) via the Siz/PIAS-RING domain (amino acids 301-410) of PIASy, and overexpression of this domain of PIASy disrupted the PKC... | Protein kinase C zeta type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01446","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIAS4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Both d-flow and ONOO(-) increased the association of PKCζ ... | |
medium_divergent_branch_01447 | JAK2 interacts with multiple proteins. One reported interaction involves an association between Jak1/Jak2 and either the target protein or Btk. Which protein, connected to JAK2 via an interaction, is encoded by the gene in question? | Tyrosine-protein kinase Tec | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01447","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JAK2 interacts with multiple proteins. One reported interaction involves an association between Jak1/Jak2 and either the target protein or Btk. Which... | |
medium_divergent_branch_01448 | BMAL1 interacts with multiple proteins. One specific interaction partner is characterized by evidence stating that it rapidly dimerizes with BMAL1 and forms a ternary complex with CBP in discrete nuclear foci in response to serum stimuli. Which protein is encoded by the gene corresponding to this specific interaction p... | Circadian locomoter output cycles protein kaput | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01448","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMAL1 interacts with multiple proteins. One specific interaction partner is characterized by evidence stating that it rapidly dimerizes with BMAL1 an... | |
medium_divergent_branch_01449 | The MYC gene interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show that, after stimulation with growth factor, this protein forms a complex with the dimer of MYC with MAX (Myc-associated factor X) via the MYC BoxII (MBII) domain.' Which protein, connected to MYC thro... | Serine/threonine-protein kinase pim-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01449","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The MYC gene interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show that, after stimulation with ... | |
medium_divergent_branch_01450 | The gene IL6ST is associated with multiple biological processes. One specific association is supported by evidence stating that SOCS3 acts as the primary inhibitor of IL-6 signaling by interacting with gp130 (the common shared chain of the IL-6 family of cytokines) and JAK1, JAK2, and TYK2 to regulate signaling duratio... | elicited macrophage | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01450","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL6ST is associated with multiple biological processes. One specific association is supported by evidence stating that SOCS3 acts as the pri... | |
medium_divergent_branch_01451 | The gene ID1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Using an immunoprecipitation method, we found that the helix-loop-helix domain of the Id-1 protein was essential for the physical interaction between Id-1 and a partner protein.' Which protein is encoded by the ge... | Caveolin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01451","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ID1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Using an immunoprecipitation method, we fo... | |
medium_divergent_branch_01452 | UBR4 interacts with multiple genes. One interaction is characterized by the following mechanism: GLK phosphorylates the interacting partner at serine residues 776 and 783, causing it to dissociate from UBR4, which acts as its E3 ligase. Which disease is causally linked to this specific interacting gene? | malaria | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01452","source_qa_id":"medium_divergent_branch_06031","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"UBR4 interacts with multiple genes. One interaction is characterized by the following mechanism: ... | |
medium_divergent_branch_01453 | CNTNAP1 is associated with multiple biological processes. One specific association is supported by evidence stating that the gene encodes contactin-associated protein 1 (Caspr-1), an essential component of paranodal junctions in both the peripheral and central nervous systems, which is necessary for establishing transv... | Schwann cell development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01453","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNTNAP1 is associated with multiple biological processes. One specific association is supported by evidence stating that the gene encodes contactin-a... | |
medium_divergent_branch_01454 | EXO1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrate that hExoI binds strongly to hMLH1, and we describe interaction regions between hExoI and the MMR proteins hMSH2, hMSH3, and hMLH1.' Which protein, among those connected to EXO1 via a binding interaction, is t... | DNA mismatch repair protein Msh3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01454","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EXO1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrate that hExoI binds strongly to hMLH1, an... | |
medium_divergent_branch_01455 | The gene CBL interacts with multiple proteins. One of these interaction partners was identified in a study that validated DPP8, the E3 ligase CBL, the deubiquitinase complex CYLD-SPATA2, and the BRISC complex components BRCC36/BRCC3 and ABRO1/ABRAXAS2 as novel interactors of a specific protein. Which protein is encoded... | Dipeptidyl peptidase 9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01455","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CBL interacts with multiple proteins. One of these interaction partners was identified in a study that validated DPP8, the E3 ligase CBL, th... | |
medium_divergent_branch_01456 | The gene CRYAB interacts with multiple other genes. One specific interaction is supported by evidence stating that the proteins are coexpressed in different tissues and associate to form hetero-oligomeric complexes. Which protein is encoded by the gene involved in this specific interaction? | Heat shock protein beta-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01456","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CRYAB interacts with multiple other genes. One specific interaction is supported by evidence stating that the proteins are coexpressed in di... | |
medium_divergent_branch_01457 | ASF1A interacts with multiple proteins. One interaction is supported by evidence stating: 'Furthermore, we demonstrate that hAsf1 proteins can interact directly with the p60 subunit of hCAF-1.' Which protein, connected to ASF1A via this specific interaction, is the gene that encodes the p60 subunit of hCAF-1? | Chromatin assembly factor 1 subunit B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01457","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ASF1A interacts with multiple proteins. One interaction is supported by evidence stating: 'Furthermore, we demonstrate that hAsf1 proteins can intera... | |
medium_divergent_branch_01458 | WDR36 is reported to interact with multiple genes. One specific interaction is supported by the following evidence: 'We identified the WD-repeat-containing protein, WDR36, as an interacting partner of the β isoform of thromboxane A(2) receptor (TPβ) by yeast two-hybrid screening.' Based on this evidence, which gene is ... | TGM2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01458","source_qa_id":"medium_divergent_branch_01958","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"WDR36 is reported to interact with multiple genes. One specific interaction is supported by the f... | |
medium_divergent_branch_01459 | PAQR3 interacts with multiple proteins. One of these interaction partners has been experimentally demonstrated to interact with PAQR3 both in vivo and in vitro. Which protein is encoded by the gene corresponding to this specific interaction partner? | DNA damage-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01459","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAQR3 interacts with multiple proteins. One of these interaction partners has been experimentally demonstrated to interact with PAQR3 both in vivo an... | |
medium_divergent_branch_01460 | MARCH5 interacts with multiple genes. Evidence for one specific interaction indicates that MARCH5 binds the partner protein, and that MARCH5-dependent ubiquitylation of this partner is significantly elevated under mitochondrial stress conditions, accompanied by an increase in the acetylation of the partner. Which disea... | adult acute respiratory distress syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01460","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARCH5 interacts with multiple genes. Evidence for one specific interaction indicates that MARCH5 binds the partner protein, and that MARCH5-dependen... | |
medium_divergent_branch_01462 | USP21 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our investigations revealed that the protein interacts with ubiquitin-specific proteases 21 (USP21), a DUB involved in the Hippo signaling pathway, and deubiquitinates the microtubule-affinity regulating kinase (MARK).' Which pro... | Ubiquitin thioesterase OTU1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01462","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP21 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our investigations revealed that the protein interacts wit... | |
medium_divergent_branch_01463 | TAB1 interacts with multiple proteins. Evidence for one interaction describes a complex containing TAK1, TAB1, and the target protein, whereas evidence for another interaction describes a complex containing TAK1, TAB1, and TAB2. Which protein, connected to TAB1 via a binding interaction, is encoded by the gene in quest... | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01463","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAB1 interacts with multiple proteins. Evidence for one interaction describes a complex containing TAK1, TAB1, and the target protein, whereas eviden... | |
medium_divergent_branch_01464 | APLF interacts with multiple proteins. One specific interaction involves a partner protein that stably binds to Xip1 via the recognition of CK2 phosphorylation sites within the partner by the Forkhead-associated (FHA) domain of Xip1. Additionally, this partner protein is required to maintain the steady-state levels of ... | DNA repair protein XRCC1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01464","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APLF interacts with multiple proteins. One specific interaction involves a partner protein that stably binds to Xip1 via the recognition of CK2 phosp... | |
medium_divergent_branch_01465 | SSRP1 interacts with multiple proteins. One of these interaction partners is reported to form a stable, approximately 600-kDa complex with the FACT complex in interphase nuclei. Which protein is encoded by the gene corresponding to this specific interaction partner? | Serine/threonine-protein kinase Nek9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01465","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SSRP1 interacts with multiple proteins. One of these interaction partners is reported to form a stable, approximately 600-kDa complex with the FACT c... | |
medium_divergent_branch_01466 | F2RL1 interacts with multiple proteins. One interaction is supported by evidence describing a novel association between PAR2 (encoded by F2RL1) and low-density lipoprotein-related protein 6, a known coreceptor of Frizzleds, which occurs following PAR2 activation. Which protein is encoded by the gene corresponding to th... | Low-density lipoprotein receptor-related protein 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01466","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"F2RL1 interacts with multiple proteins. One interaction is supported by evidence describing a novel association between PAR2 (encoded by F2RL1) and l... | |
medium_divergent_branch_01467 | IRS2 interacts with multiple genes. One interaction is supported by evidence stating: 'The role of IRS-2 as a signaling molecule for GH is further demonstrated by the finding that GH stimulates association of IRS-2 with the 85-kDa regulatory subunit of phosphatidylinositol 3'-kinase and with the protein-tyrosine phosph... | ovarian cyst | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01467","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRS2 interacts with multiple genes. One interaction is supported by evidence stating: 'The role of IRS-2 as a signaling molecule for GH is further de... | |
medium_divergent_branch_01468 | CD19 is associated with multiple biological processes. One association is supported by evidence stating that mutation of the CD19 gene causes a type of hypogammaglobulinemia characterized by a defective response of mature B cells to antigenic stimulation. Which biological process, connected to the process supported by ... | B cell mediated immunity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01468","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD19 is associated with multiple biological processes. One association is supported by evidence stating that mutation of the CD19 gene causes a type ... | |
medium_divergent_branch_01469 | The gene SLC2A1 is associated with multiple molecular functions. One specific function is supported by experimental evidence stating that cysteine substitutions at Leu(204) and Pro(205) abolished transport activity, whereas substitutions at Ile(192), Pro(196), Gln(200), and Gly(201) resulted in inhibition of activity r... | hexose transmembrane transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01469","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SLC2A1 is associated with multiple molecular functions. One specific function is supported by experimental evidence stating that cysteine su... | |
medium_divergent_branch_01470 | CENP-E interacts with multiple proteins. One specific interaction is supported by evidence stating: 'CENP-E was phosphorylated in vitro by MAP kinase on sites that are known to regulate its interactions with microtubules and was found to associate in vivo preferentially with the active MAP kinase during mitosis.' Which... | Mitogen-activated protein kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01470","source_qa_id":"medium_divergent_branch_02219","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CENP-E interacts with multiple proteins. One specific interaction is supported by evidence statin... | |
medium_divergent_branch_01471 | The gene CCNA2 interacts with multiple protein partners. One specific interaction is supported by evidence stating that the protein product of the selected partner gene forms a complex in vitro and in vivo with Fen1. Which protein is encoded by the gene that binds to CCNA2 and satisfies this evidence? | Cyclin-dependent kinase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01471","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CCNA2 interacts with multiple protein partners. One specific interaction is supported by evidence stating that the protein product of the se... | |
medium_divergent_branch_01474 | ARNT interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we show that ARNT uses a single PAS domain to interact with two coiled coil coactivators, a TRIP family member and CoCoA.' Which disease is connected to the gene identified by this evidence through genomic alterations? | fetal growth restriction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01474","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARNT interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we show that ARNT uses a single PAS domain to in... | |
medium_divergent_branch_01475 | MCL1 interacts with multiple proteins. One interaction is supported by evidence describing the crystal structures of the pro-survival proteins Mcl-1 and Bcl-x(L) in complex with a 34-mer peptide from the interacting partner that encompasses its BH3 domain. Which protein is this interacting partner? | Apoptosis regulator BAX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01475","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCL1 interacts with multiple proteins. One interaction is supported by evidence describing the crystal structures of the pro-survival proteins Mcl-1 ... | |
medium_divergent_branch_01476 | The gene DCTN4 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'The dynactin subunit p62 (dynactin 4; DCTN4) was identified as an interacting partner, and this interaction was confirmed by co-immunoprecipitation from mammalian cells.' Which protein is encoded by the gene ... | Copper-transporting ATPase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01476","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DCTN4 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'The dynactin subunit p62 (dynactin 4;... |
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