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medium_divergent_branch_01477 | PPM1A interacts with multiple genes. One specific interaction is supported by evidence stating that the interacting partner was found to interact with PPM1A, and that down-regulation of this partner inhibited the ubiquitination of PPM1A. Which gene is connected to PPM1A through this specific 'interacts with' relationsh... | TRIM41 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01477","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPM1A interacts with multiple genes. One specific interaction is supported by evidence stating that the interacting partner was found to interact wit... | |
medium_divergent_branch_01478 | NDRG1 interacts with multiple genes. One specific interaction is characterized by evidence showing that NDRG1 binds to the constitutively active Q67L mutant of the partner protein but not to its GDP-bound S22N mutant, identifying NDRG1 as a novel effector for this partner. Which disease is associated with this specific... | lupus vulgaris | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01478","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NDRG1 interacts with multiple genes. One specific interaction is characterized by evidence showing that NDRG1 binds to the constitutively active Q67L... | |
medium_divergent_branch_01480 | VPS13A is associated with multiple biological processes. One association is supported by evidence stating: 'our results suggest that the decrease in autophagy observed in the absence of VPS13A may be the result of a more general defect in endocytic trafficking and lysosomal degradation.' Which biological process, conne... | protein catabolic process in the vacuole | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01480","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS13A is associated with multiple biological processes. One association is supported by evidence stating: 'our results suggest that the decrease in ... | |
medium_divergent_branch_01481 | The olfactory receptor OR51E2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our results further showed that β-ionone stimulates melanogenesis and dendritogenesis.' Which biological process, connected to the process supported by this evidence via an 'is a' relations... | pigment cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01481","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The olfactory receptor OR51E2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our results furthe... | |
medium_divergent_branch_01482 | TFAP2A interacts with multiple genes. One specific interaction is supported by evidence stating: 'Thus, we conclude that the tumor suppressor activity of AP2alpha is mediated through a direct interaction with [the protein encoded by the interacting gene].' Which protein is encoded by the gene that interacts with TFAP2A... | Cellular tumor antigen p53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01482","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TFAP2A interacts with multiple genes. One specific interaction is supported by evidence stating: 'Thus, we conclude that the tumor suppressor activit... | |
medium_divergent_branch_01484 | CDK5 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a chemical genetic approach, we identified Cdc25A, the shared protein and Cdc25C as direct CDK5 substrates in mouse brain lysates.' Which protein product is encoded by the gene corresponding to this shared protein? | M-phase inducer phosphatase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01484","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK5 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a chemical genetic approach, we identified Cdc25A, th... | |
medium_divergent_branch_01486 | The stomach is classified as a type of anatomy. One such classification is supported by the description: 'An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium.' Which anatomical category is ... | subdivision of tube | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01486","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The stomach is classified as a type of anatomy. One such classification is supported by the description: 'An expanded region of the vertebrate alimen... | |
medium_divergent_branch_01487 | RAF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we show that the signaling molecule Raf-1 can physically interact with Rb and a specific retinoblastoma family protein in vitro and in vivo and that this interaction can be detected in mammalian cells without overex... | Retinoblastoma-like protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01487","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we show that the signaling molecule Raf-1 ca... | |
medium_divergent_branch_01488 | ANXA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the current study, our proteomic analysis using two-dimensional electrophoresis, matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF-MS) and nano LC-MS/MS, and immunoprecipitation revealed t... | intellectual disability | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01488","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANXA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the current study, our proteomic analysis using two-dim... | |
medium_divergent_branch_01489 | USP9X interacts with multiple genes. One interaction is supported by evidence stating: 'We show that USP9X interacts with both these ubiquitin E3 ligases, regulating their abundance through the control of protein stability.' Which gene is connected to USP9X through this specific interaction, and what is the name of the... | EIF4E2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01489","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP9X interacts with multiple genes. One interaction is supported by evidence stating: 'We show that USP9X interacts with both these ubiquitin E3 lig... | |
medium_divergent_branch_01490 | The gene EIF2S1 interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'Point mutations altering the eIF2α-binding motif impair the ability of the interacting protein to interact with eIF2α, promote eIF2α dephosphorylation, and suppress PKR toxicity in yeast.' Which pro... | Protein phosphatase 1 regulatory subunit 15A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01490","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF2S1 interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'Point mutations altering th... | |
medium_divergent_branch_01491 | RAD21 is known to interact with multiple proteins. One specific interaction was identified through mass spectrometry analysis of dual-affinity purifications, which revealed a deubiquitinase as a novel cohesin-interacting protein. Which protein is encoded by the gene corresponding to this deubiquitinase? | Ubiquitin carboxyl-terminal hydrolase 13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01491","source_qa_id":"medium_divergent_branch_00323","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RAD21 is known to interact with multiple proteins. One specific interaction was identified throug... | |
medium_divergent_branch_01492 | SNX9 interacts with multiple proteins. One specific interaction is characterized by evidence stating: 'Using truncated proteins, we found that the interaction with SNX9 is mediated by the proline-rich domain (PRD) of the interaction partner, a domain distinct from the conventional WW recognition domain, and the SH3 dom... | E3 ubiquitin-protein ligase Itchy homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01492","source_qa_id":"medium_divergent_branch_04936","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SNX9 interacts with multiple proteins. One specific interaction is characterized by evidence stat... | |
medium_divergent_branch_01493 | EGLN3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our results demonstrate that, while EGLN1 is able to recognize both ODDs within full length HIF1alpha protein, EGLN3 only binds to CODD.' Which protein product is encoded by the gene corresponding to this specific binding partner... | Hypoxia-inducible factor 1-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01493","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EGLN3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our results demonstrate that, while EGLN1 is able to recog... | |
medium_divergent_branch_01494 | hsa-miR-328 regulates more than one cell type. Evidence for one of these regulatory connections states: 'Furthermore, we revealed that ROS produced by macrophages triggered CD44 expression through suppression of miR-328 in gastric cancer cells.' Which cell type is the developmental precursor to the cell type described ... | monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01494","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-328 regulates more than one cell type. Evidence for one of these regulatory connections states: 'Furthermore, we revealed that ROS produced b... | |
medium_divergent_branch_01495 | KLF8 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Co-immunoprecipitation analyses demonstrated that KLF8 interacted with these co-activators whereas the Q118N-Q248N mutant did not.' Which protein is encoded by the gene connected to KLF8 through this specific intera... | CREB-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01495","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLF8 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Co-immunoprecipitation analyses demonstrated... | |
medium_divergent_branch_01497 | MCM2 is associated with multiple cellular components. One association is supported by evidence that the MCM2 complex, when bound to this component, is phosphorylated by Cdc7/Dbf4 during the G1/S transition, coinciding with the initiation of DNA replication. Which cellular component is this specific association linked t... | chromosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01497","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCM2 is associated with multiple cellular components. One association is supported by evidence that the MCM2 complex, when bound to this component, i... | |
medium_divergent_branch_01498 | ARHGEF16 interacts with multiple proteins. One of these interactions is supported by evidence stating that Tax-interacting-protein 1 interacts with the partner via its carboxyl PDZ binding motif. Which protein is encoded by the gene corresponding to this specific interaction partner? | Tax1-binding protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01498","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARHGEF16 interacts with multiple proteins. One of these interactions is supported by evidence stating that Tax-interacting-protein 1 interacts with t... | |
medium_divergent_branch_01499 | Cyclin D1 (CCND1) interacts with multiple proteins. One specific interaction involves Thr286-phosphorylated cyclin D1 being recognized by an SCF ubiquitin ligase complex, where FBX4 and alphaB crystallin govern substrate specificity. Which protein, encoded by a gene that interacts with CCND1 in this specific context, i... | Cullin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01499","source_qa_id":"medium_divergent_branch_06238","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Cyclin D1 (CCND1) interacts with multiple proteins. One specific interaction involves Thr286-phos... | |
medium_divergent_branch_01500 | PPARG interacts with multiple proteins. One interaction is supported by evidence stating: 'Both endogenous and exogenous PPARγ associated with a deubiquitinating enzyme in co-immunoprecipitation analysis.' Which protein, encoded by the gene interacting with PPARG in this specific context, is the subject of this evidenc... | Ubiquitin carboxyl-terminal hydrolase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01500","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPARG interacts with multiple proteins. One interaction is supported by evidence stating: 'Both endogenous and exogenous PPARγ associated with a deub... | |
medium_divergent_branch_01501 | NOS1AP is associated with multiple biological processes. One association is supported by evidence showing that NOS1AP exhibits high co-localization with the L-type calcium channel and the inwardly rectifying potassium channel Kir3.1, low co-localization with the ryanodine receptor (RyR2) and alpha-sarcomeric actin, and... | cardiac muscle cell action potential | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01501","source_qa_id":"medium_divergent_branch_02873","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"NOS1AP is associated with multiple biological processes. One association is supported by evidence... | |
medium_divergent_branch_01502 | The gene CHUK interacts with multiple partners. One interaction is supported by evidence stating: 'Here, we show for the first time that [Protein X], but not p53, is stabilized by physical interaction with nuclear IkappaB kinase (IKK)-alpha to enhance cisplatin (CDDP)-induced apoptosis.' Which protein is encoded by the... | Tumor protein p73 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01502","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CHUK interacts with multiple partners. One interaction is supported by evidence stating: 'Here, we show for the first time that [Protein X],... | |
medium_divergent_branch_01503 | RAD21 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that the hRAD21 subunit of the cohesin complex directly interacts with the ATPase subunit SNF2h.' Which disease is associated with the gene identified by this specific interaction evidence through genomic alterations? | extraskeletal Ewing sarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01503","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD21 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that the hRAD21 subunit of the cohesin complex direct... | |
medium_divergent_branch_01504 | NME2 interacts with multiple proteins. One specific interaction is described as follows: 'In the present study, we report the identification by yeast two-hybrid screening of Nm23-H2, a nucleoside diphosphate kinase, as a new interacting molecular partner with the C-terminal tail of TP beta.' Identify the disease that i... | kidney failure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01504","source_qa_id":"medium_divergent_branch_03236","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"NME2 interacts with multiple proteins. One specific interaction is described as follows: 'In the ... | |
medium_divergent_branch_01505 | The gene TUBA1B is enriched in multiple cell types. One of these cell types exhibits a mean expression of 815.92 TPM, a z-score of 2.03, and a fold enrichment of 2.75. Which cell type does this specific cell develop from? | classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01505","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TUBA1B is enriched in multiple cell types. One of these cell types exhibits a mean expression of 815.92 TPM, a z-score of 2.03, and a fold e... | |
medium_divergent_branch_01506 | The biological process 'regulation of NK T cell proliferation' is defined as any process that modulates the frequency, rate, or extent of natural killer T cell proliferation. This process is a subtype of a broader regulatory process. Which biological process is directly regulated by this broader parent process? | alpha-beta T cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01506","source_qa_id":"medium_divergent_branch_07001","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of NK T cell proliferation' is defined as any process that mod... | |
medium_divergent_branch_01507 | CTCF interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified the largest subunit of Pol II (LS Pol II) as a protein significantly colocalizing with CTCF in the nucleus and specifically interacting with CTCF in vivo and in vitro.' What is the name of the protein encoded by the ... | DNA-directed RNA polymerase II subunit RPB1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01507","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CTCF interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified the largest subunit of Pol II (LS Pol II) as ... | |
medium_divergent_branch_01508 | DEFB4A is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Interestingly, although hBD2:Ig bound to both human and mouse CCR6-expressing cells, mBD4:Ig did only bind to mCCR6-expressing cells but not to hCCR6-expressing cells.' Whic... | CCR chemokine receptor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01508","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DEFB4A is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'In... | |
medium_divergent_branch_01510 | AMOTL1 interacts with multiple proteins. One interaction partner is described by the evidence: 'We show that this protein binds a number of polarity-associated proteins, in particular members of the angiomotin (AMOT) family.' Which cellular component is this specific interaction partner located in? | cytosol | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01510","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMOTL1 interacts with multiple proteins. One interaction partner is described by the evidence: 'We show that this protein binds a number of polarity-... | |
medium_divergent_branch_01511 | The gene BCL2L11 (encoding Bim) has multiple interacting partners. One interaction is supported by evidence stating: 'Importantly, it was found that a mitotic cyclin co-immunoprecipitates with endogenous Bim in mitotic extracts.' Which protein is encoded by the gene that interacts with BCL2L11 based on this specific ev... | G2/mitotic-specific cyclin-B1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01511","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BCL2L11 (encoding Bim) has multiple interacting partners. One interaction is supported by evidence stating: 'Importantly, it was found that ... | |
medium_divergent_branch_01512 | RAD50 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we demonstrate that a specific DNA repair protein interacts with both MRE11/RAD50/NBS1 (MRN) and BRCA1 in a cell cycle regulated manner, with the former requiring its WHD and occurring predominantly in early S phase.' Which dis... | craniosynostosis 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01512","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD50 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we demonstrate that a specific DNA repair protein intera... | |
medium_divergent_branch_01513 | RNF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have determined the crystal structure of a complex between the Bmi1/Ring1b RING-RING heterodimer and the E2 enzyme [E2 enzyme] and find that [E2 enzyme] interacts with Ring1b only, in a manner fairly typical of E2-E3 interactio... | Ubiquitin-conjugating enzyme E2 D3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01513","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have determined the crystal structure of a complex betwe... | |
medium_divergent_branch_01514 | CHEK1 interacts with multiple genes. One interaction is supported by evidence stating: 'In contrast, we showed that radiation-induced phosphorylation of Chk1 at S345 was associated with binding of Chk1 to a tumor suppressor protein, p21, and 14-3-3 sigma, and that UCN-01 inhibited S345 phosphorylation.' Which disease i... | preeclampsia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01514","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHEK1 interacts with multiple genes. One interaction is supported by evidence stating: 'In contrast, we showed that radiation-induced phosphorylation... | |
medium_divergent_branch_01515 | Osteocytes are anatomical entities that are part of specific tissue types. One such tissue type is characterized by mature osteoblasts embedded in the bone matrix, occupying lacunae and connecting to adjacent cells via canaliculi. Which tissue type, connected to osteocytes via a 'part of' relationship, is defined by th... | skeletal tissue | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01515","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Osteocytes are anatomical entities that are part of specific tissue types. One such tissue type is characterized by mature osteoblasts embedded in th... | |
medium_divergent_branch_01516 | DDRGK1 is associated with multiple biological processes. One association is supported by evidence that depleting DDRGK1 inhibits cell proliferation and invasion. Which biological process, connected to the process supported by this evidence, is linked via a 'positively regulates' relationship? | cell population proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01516","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDRGK1 is associated with multiple biological processes. One association is supported by evidence that depleting DDRGK1 inhibits cell proliferation a... | |
medium_divergent_branch_01517 | CREB1 interacts with multiple genes. One such interaction is supported by evidence stating: 'A co-immunoprecipitation assay revealed a physical interaction between CREB and a Wnt signaling pathway component.' Which disease is causally linked to the gene identified by this evidence? | proteinuria | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01517","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CREB1 interacts with multiple genes. One such interaction is supported by evidence stating: 'A co-immunoprecipitation assay revealed a physical inter... | |
medium_divergent_branch_01518 | MIR195 is associated with multiple biological processes. One association is supported by evidence that miR-195 suppresses the expression of inflammatory cytokines, including IL-6, in vitro and in vivo. Which biological process, connected to the process supported by this evidence, is the target of a 'negatively regulate... | interleukin-6 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01518","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR195 is associated with multiple biological processes. One association is supported by evidence that miR-195 suppresses the expression of inflammat... | |
medium_divergent_branch_01519 | The gene BFAR interacts with multiple other genes. One specific interaction is supported by evidence stating: 'The BAR protein contains a SAM domain, which is required for its interactions with a specific anti-apoptotic protein and Bcl-X(L) and for suppression of Bax-induced cell death in both mammalian cells and yeast... | Apoptosis regulator Bcl-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01519","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BFAR interacts with multiple other genes. One specific interaction is supported by evidence stating: 'The BAR protein contains a SAM domain,... | |
medium_divergent_branch_01520 | LAMTOR2 is known to interact with multiple proteins. One specific interaction partner is described as an uncharacterized protein with sequence similarity to amino acid transporters, functioning as a lysosomal transmembrane protein that interacts with Rag GTPases and Ragulator in an amino acid-sensitive manner. Which pr... | Neutral amino acid transporter 9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01520","source_qa_id":"medium_divergent_branch_00522","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"LAMTOR2 is known to interact with multiple proteins. One specific interaction partner is describe... | |
medium_divergent_branch_01521 | TLE3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that this protein forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtBP1 and regulates Wnt/β-catenin-dependent gene expression.' Which protein, connected to TLE3 via an interaction, is described... | Zinc finger protein Gfi-1b | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01521","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TLE3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that this protein forms complexes with β-caten... | |
medium_divergent_branch_01522 | ACOT2 interacts with multiple proteins. One of these interaction partners was validated in human neuroblastoma cells or brain tissues alongside a specific set of candidates including EEF1A1, FLNA, ITPRIP, CYP11A1, MT-CO2, GPR175, ACOT2, and QPRT. Which protein, among the interaction partners of ACOT2, is encoded by the... | Neuroligin-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01522","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACOT2 interacts with multiple proteins. One of these interaction partners was validated in human neuroblastoma cells or brain tissues alongside a spe... | |
medium_divergent_branch_01523 | KDM1A interacts with multiple proteins. One specific interaction involves a transcriptional co-repressor complex containing LSD1, a protein encoded by the gene RCOR1, and HDAC1 (termed LCH), which represses transcription by coordinately removing histone modifications associated with transcriptional activation. Which di... | heparin-induced thrombocytopenia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01523","source_qa_id":"medium_divergent_branch_07103","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"KDM1A interacts with multiple proteins. One specific interaction involves a transcriptional co-re... | |
medium_divergent_branch_01524 | FLRT1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that FLRT1, FLRT2, and FLRT3 form a novel gene family identified in a screen for proteins expressed in muscle that belong to this specific component. Which broader cellular ... | external encapsulating structure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01524","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FLRT1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating th... | |
medium_divergent_branch_01525 | SOX18 is associated with multiple biological processes. One association is supported by evidence stating that the SOX18 transcription factor is a key regulator of murine and human blood vessel formation. Which biological process, connected to SOX18 via an 'involved in' relationship, is the parent term (via an 'is a' re... | anatomical structure formation involved in morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01525","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX18 is associated with multiple biological processes. One association is supported by evidence stating that the SOX18 transcription factor is a key... | |
medium_divergent_branch_01526 | In a study of Orthohepevirus A infection in hepatocytes (GSE135619), one downregulated gene exhibits a log2 fold change of -1.621 and an adjusted p-value of 0.04032. What molecular function is enabled by this specific gene? | protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01526","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In a study of Orthohepevirus A infection in hepatocytes (GSE135619), one downregulated gene exhibits a log2 fold change of -1.621 and an adjusted p-v... | |
medium_divergent_branch_01527 | SPEN interacts with multiple proteins. One interaction is supported by evidence stating: 'The interaction between MINT and a ubiquitin-conjugating enzyme in mammalian cells was further proved by a series of biochemical assays including the mammalian two-hybrid assay, GST pull-down assay, and co-immunoprecipitation assa... | Ubiquitin-conjugating enzyme E2 E2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01527","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SPEN interacts with multiple proteins. One interaction is supported by evidence stating: 'The interaction between MINT and a ubiquitin-conjugating en... | |
medium_divergent_branch_01528 | GIT1 interacts with multiple proteins. One specific interaction partner is described as a multidomain protein with GTPase-activating protein activity for the ADP-ribosylation factor family of small GTPases, which are known to regulate protein trafficking and the actin cytoskeleton. Which cellular component is this spec... | presynaptic active zone | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01528","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GIT1 interacts with multiple proteins. One specific interaction partner is described as a multidomain protein with GTPase-activating protein activity... | |
medium_divergent_branch_01529 | Orthohepevirus A is reported to upregulate multiple genes. One specific upregulation event is characterized by a log2 fold change of approximately 1.16 and an adjusted p-value of approximately 0.034. Which protein is encoded by the gene associated with this specific statistical evidence? | Zinc finger protein 614 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01529","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Orthohepevirus A is reported to upregulate multiple genes. One specific upregulation event is characterized by a log2 fold change of approximately 1.... | |
medium_divergent_branch_01530 | GTF2I interacts with multiple genes. One of these interactions is supported by evidence stating: 'We further show that TFII-I also binds to the upstream high-affinity USF site (E box), that USF also binds to the Inr, and that TFII-I and USF interact cooperatively at both Inr and E box sites.' Which disease is associate... | hyperlipidemia, combined, 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01530","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GTF2I interacts with multiple genes. One of these interactions is supported by evidence stating: 'We further show that TFII-I also binds to the upstr... | |
medium_divergent_branch_01531 | ESCO2 interacts with multiple proteins. One interaction partner is distinguished by the fact that ESCO2, but not ESCO1, binds to the MCM complex via a unique ESCO2 domain. Which protein, encoded by the gene connected to ESCO2 through this specific interaction, is the subject of this evidence? | DNA replication licensing factor MCM7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01531","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ESCO2 interacts with multiple proteins. One interaction partner is distinguished by the fact that ESCO2, but not ESCO1, binds to the MCM complex via ... | |
medium_divergent_branch_01532 | COPB1 interacts with multiple proteins. One of these interaction partners was identified in a study that reported, for the first time, members of the coatomer I (COPI) complex as interaction partners of hSAC1. Which protein is encoded by the gene corresponding to this specific interaction partner? | Phosphatidylinositol-3-phosphatase SAC1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01532","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COPB1 interacts with multiple proteins. One of these interaction partners was identified in a study that reported, for the first time, members of the... | |
medium_divergent_branch_01533 | FLVCR1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Here, we identify Flvcr1b, a mitochondrial Flvcr1 isoform that promotes heme efflux into the cytoplasm.' Which biological process, connected to the process implied by this evidence via an 'is a' relation... | intracellular transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01533","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FLVCR1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Here, we identify Flvcr1b, a mit... | |
medium_divergent_branch_01534 | GFER interacts with multiple genes. One of these interaction partners is described by the following evidence: 'By interacting with this gene product, ALR inhibits its nuclear import and dramatically decreases the transcriptional level of UBA2.' Which disease is associated with this specific gene via a biomarker relatio... | carcinoma of esophagus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01534","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GFER interacts with multiple genes. One of these interaction partners is described by the following evidence: 'By interacting with this gene product,... | |
medium_divergent_branch_01535 | SYNJ2BP interacts with multiple proteins. One interaction is supported by evidence stating: 'Using yeast two-hybrid screening, we have identified a mouse Postsynaptic density 95/Discs large/Zona occludens-1 (PDZ) protein that interacts with activin type II receptors (ActRIIs).' Which protein, connected to SYNJ2BP via t... | Activin receptor type-2A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01535","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SYNJ2BP interacts with multiple proteins. One interaction is supported by evidence stating: 'Using yeast two-hybrid screening, we have identified a m... | |
medium_divergent_branch_01537 | NRG1 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence that rhGGF2 (30 ng/ml) provoked an approximate 2-fold increase in embryonic cardiac myocyte proliferation. Which biological process is connected to this specific NRG1-associated pr... | cardiac muscle cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01537","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NRG1 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence that rhGG... | |
medium_divergent_branch_01539 | NEDD9 interacts with multiple genes. One of these interaction partners was identified in a yeast two-hybrid assay revealing that both this gene and zyxin interact with CasL/HEF1, a member of the Cas family. Which disease is associated with this gene? | glioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01539","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NEDD9 interacts with multiple genes. One of these interaction partners was identified in a yeast two-hybrid assay revealing that both this gene and z... | |
medium_divergent_branch_01540 | MORF4L1 interacts with multiple genes. One of these interaction partners is described in literature as binding directly to the conserved chromodomain protein MRG15, a component of histone acetyltransferase-deacetylase complexes. Which biological process is this specific interaction partner involved in? | double-strand break repair via homologous recombination | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01540","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MORF4L1 interacts with multiple genes. One of these interaction partners is described in literature as binding directly to the conserved chromodomain... | |
medium_divergent_branch_01541 | POC1B interacts with multiple proteins. One of these interactions was identified through yeast two-hybrid screening of a human retinal cDNA library, which revealed the interacting partner as a binary interaction partner of POC1B. Which protein is encoded by the gene corresponding to this specific interacting partner? | Protein FAM161A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01541","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POC1B interacts with multiple proteins. One of these interactions was identified through yeast two-hybrid screening of a human retinal cDNA library, ... | |
medium_divergent_branch_01543 | The paravertebral ganglion is a type of anatomy connected to two broader anatomical categories. One of these categories is described as being part of a bilaterally paired set of sympathetic ganglia located anterior and lateral to the spinal cord. Which broader anatomical category is connected to the paravertebral gangl... | trunk | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01543","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The paravertebral ganglion is a type of anatomy connected to two broader anatomical categories. One of these categories is described as being part of... | |
medium_divergent_branch_01544 | ANKRA2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show here that [the interacting protein] is a major partner of ANKRA2 but not RFXANK in cells.' Which protein, encoded by the gene connected to ANKRA2 via this specific interaction, is the subject of this statement? | Coiled-coil domain-containing protein 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01544","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANKRA2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show here that [the interacting protein] is a... | |
medium_divergent_branch_01545 | VOPP1 is associated with multiple cellular components via 'located_in' relationships. One association is supported by evidence showing that VOPP1, when tagged with a fluorescence reporter or visualized via antibodies against recombinant and native forms, exhibits an intracellular vesicular pattern of localization. Whic... | vesicle membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01545","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VOPP1 is associated with multiple cellular components via 'located_in' relationships. One association is supported by evidence showing that VOPP1, wh... | |
medium_divergent_branch_01546 | Eosinophil differentiation is enabled by more than one cell type. Evidence for one of these enabling cells describes it as 'A myeloblast committed to the eosinophil lineage.' Which cell is the precursor to this specific enabling cell, connected via the 'develops from' relationship? | eosinophil progenitor cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01546","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Eosinophil differentiation is enabled by more than one cell type. Evidence for one of these enabling cells describes it as 'A myeloblast committed to... | |
medium_divergent_branch_01547 | The gene BCL2L10 interacts with multiple other genes. Experimental evidence indicates that the Bcl-B protein binds to Bcl-2, Bcl-X(L), and a specific partner protein, but does not bind to Bak. Which protein is encoded by the gene that corresponds to this specific binding partner? | Apoptosis regulator BAX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01547","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BCL2L10 interacts with multiple other genes. Experimental evidence indicates that the Bcl-B protein binds to Bcl-2, Bcl-X(L), and a specific... | |
medium_divergent_branch_01549 | SIN3A interacts with multiple proteins. One specific interaction is characterized by direct binding that promotes the deacetylation of the partner protein. Which protein, connected to SIN3A via this specific interaction, is encoded by the gene in question? | Signal transducer and activator of transcription 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01549","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIN3A interacts with multiple proteins. One specific interaction is characterized by direct binding that promotes the deacetylation of the partner pr... | |
medium_divergent_branch_01550 | MTOR interacts with multiple genes. One of these interaction partners is characterized by evidence that Raptor directly binds to it and serves as a scaffold for mTOR-mediated phosphorylation of IRS-1 on Ser636/639. Which protein is encoded by the gene connected to MTOR through this specific interaction? | Insulin receptor substrate 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01550","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTOR interacts with multiple genes. One of these interaction partners is characterized by evidence that Raptor directly binds to it and serves as a s... | |
medium_divergent_branch_01552 | ANXA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In cellular extracts, endogenous annexin I and the 10-kDa protein associated in a reversible Ca(2+)-dependent manner.' Which protein, encoded by the gene involved in this specific interaction, is the target of the 'encodes' relat... | Protein S100-A11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01552","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANXA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In cellular extracts, endogenous annexin I and the 10-kDa ... | |
medium_divergent_branch_01553 | The locus ceruleus is anatomically classified as a specific type of structure. Evidence for this classification describes the entity as a dense cluster of neurons within the dorsorostral pons, serving as the major location of neurons that release norepinephrine throughout the brain and responsible for physiological res... | nucleus of brain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01553","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The locus ceruleus is anatomically classified as a specific type of structure. Evidence for this classification describes the entity as a dense clust... | |
medium_divergent_branch_01554 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.706 and an adjusted p-value of 0.0219. For which disease is that selected gene recorded as a biomarker? | asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01554","source_qa_id":"medium_divergent_branch_05540","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_01555 | The dopamine D2 receptor (DRD2) interacts with multiple proteins. One specific interaction is characterized by the direct binding of a protein encoded by the PAWR gene to the dopamine D2 receptor via the calmodulin binding motif in the third cytoplasmic loop. Which disease is causally linked to the gene encoding this i... | benign neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01555","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The dopamine D2 receptor (DRD2) interacts with multiple proteins. One specific interaction is characterized by the direct binding of a protein encode... | |
medium_divergent_branch_01556 | KMT2C interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that unlike MLL1, the MLL3 SET domain assembles with the [protein]/Ash2L heterodimer independently of the Win motif-WDR5 interaction.' Which protein, connected to KMT2C via a binding interaction, is encoded by the gene c... | Retinoblastoma-binding protein 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01556","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KMT2C interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that unlike MLL1, the MLL3 SET domain assembles w... | |
medium_divergent_branch_01557 | UBE2D2 interacts with multiple genes. Evidence for one specific interaction states: 'We found that UBE2D2, but not other E2s tested, specifically binds to the catalytic domain of this interaction partner and promotes the catalyzed Ub chain formation by this partner.' Which disease is associated with this interaction pa... | neurodevelopmental disorder with absent speech and movement and behavioral abnormalities | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01557","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2D2 interacts with multiple genes. Evidence for one specific interaction states: 'We found that UBE2D2, but not other E2s tested, specifically bin... | |
medium_divergent_branch_01559 | The gene RARB forms a heterodimer with another nuclear receptor. Evidence for this interaction describes the crystal structure of the complex between the RARbeta/[RXRA] ligand-binding domain heterodimer, its 9-cis retinoic acid ligand, and an LXXLL-containing peptide derived from the TRAP220 coactivator. Which protein ... | Retinoic acid receptor RXR-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01559","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RARB forms a heterodimer with another nuclear receptor. Evidence for this interaction describes the crystal structure of the complex between... | |
medium_divergent_branch_01560 | POT1 interacts with multiple proteins. One interaction is supported by evidence stating: 'After control subtraction and data filtering, we found that the protein encoded by NCBIGene:7014 and POT1 co-purified all six members of the telomere protein complex, while TRF1 identified five of six components at frequencies tha... | Telomeric repeat-binding factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01560","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POT1 interacts with multiple proteins. One interaction is supported by evidence stating: 'After control subtraction and data filtering, we found that... | |
medium_divergent_branch_01561 | FOXA1 interacts with multiple genes. One specific interaction is supported by evidence stating that the partner protein interacted with the pioneer factor FOXA1. Which disease is associated with this specific interacting partner? | essential thrombocythemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01561","source_qa_id":"medium_divergent_branch_07117","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FOXA1 interacts with multiple genes. One specific interaction is supported by evidence stating th... | |
medium_divergent_branch_01562 | SMAD7 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: A protein complex involving the interacting partner and histone deacetylase binds to the promoter region of TGF-beta1 responsive genes containing the Smad-responsive element (SRE) to inhibit TGF-beta1 signaling... | Zinc finger E-box-binding homeobox 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01562","source_qa_id":"medium_divergent_branch_01024","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SMAD7 interacts with multiple proteins. One specific interaction is characterized by the followin... | |
medium_divergent_branch_01563 | CXCR5 interacts with multiple G-protein alpha subunits. One specific interaction involves a complex containing Gαi2, Gβ3, and Gγ9 in C4-2B and PC3 cell lines, which couples to CXCR5 and dissociates upon CXCL13 stimulation. Which disease is associated with the gene encoding this specific G-protein alpha subunit? | ventricular tachycardia, familial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01563","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXCR5 interacts with multiple G-protein alpha subunits. One specific interaction involves a complex containing Gαi2, Gβ3, and Gγ9 in C4-2B and PC3 ce... | |
medium_divergent_branch_01564 | The term 'extra-ocular muscle' is a subtype of multiple anatomical structures. One such structure is described as skeletal muscle derived from cranial mesoderm that controls eye movements. Which broader anatomical category is this specific structure a subtype of? | skeletal muscle organ, vertebrate | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01564","source_qa_id":"medium_divergent_branch_06844","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The term 'extra-ocular muscle' is a subtype of multiple anatomical structures. One such structure... | |
medium_divergent_branch_01565 | RXRA interacts with multiple genes. One of these interactions is supported by evidence stating: 'All [the interacting partner] mutants formed heterodimer with RXRα at a similar level to that observed with wild-type [the interacting partner].' Which disease is therapeutically linked to the gene identified by this specif... | epilepsy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01565","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RXRA interacts with multiple genes. One of these interactions is supported by evidence stating: 'All [the interacting partner] mutants formed heterod... | |
medium_divergent_branch_01566 | CCR1 is associated with multiple biological processes. One association is supported by evidence stating: 'These cells responded to RANTES, macrophage inflammatory protein-1alpha, and monocyte chemotactic protein-2 to mediate phospholipase C activation, intracellular Ca(2+) mobilization and exocytosis.' Which biological... | regulation of biological quality | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01566","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCR1 is associated with multiple biological processes. One association is supported by evidence stating: 'These cells responded to RANTES, macrophage... | |
medium_divergent_branch_01567 | SMARCAD1 interacts with multiple genes. One interaction partner is identified as a component of the RNA polymerase III general transcription factor TFIIIC, based on endogenous co-immunoprecipitation experiments in mouse and human models. Which disease is associated with this specific interaction partner? | neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01567","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMARCAD1 interacts with multiple genes. One interaction partner is identified as a component of the RNA polymerase III general transcription factor T... | |
medium_divergent_branch_01568 | VPS28 interacts with multiple proteins. One specific interaction is supported by evidence showing that TSG101 and the interacting partner co-immunoprecipitated with a FLAG-tagged version of that partner, and all three proteins comigrated in soluble complexes of approximately 350 kDa, consistent with the size of human E... | Vacuolar protein sorting-associated protein 37B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01568","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS28 interacts with multiple proteins. One specific interaction is supported by evidence showing that TSG101 and the interacting partner co-immunopr... | |
medium_divergent_branch_01569 | RAB11A is known to bind to multiple gene products. One specific interaction is supported by evidence stating: 'We show with purified TPbeta intracellular domains fused to GST and HIS-Rab11 proteins that Rab11 interacts directly with the first intracellular loop and the C-tail of TPbeta.' Identify the gene product corre... | TGM2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01569","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB11A is known to bind to multiple gene products. One specific interaction is supported by evidence stating: 'We show with purified TPbeta intracell... | |
medium_divergent_branch_01571 | Gephyrin (GPHN) interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we have analyzed the interaction between the GlyR and recombinant gephyrin and identified a gephyrin binding site in the cytoplasmic loop between the third and fourth transmembrane segments of the beta subunit.' Wh... | NBEA | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01571","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Gephyrin (GPHN) interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we have analyzed the interaction between th... | |
medium_divergent_branch_01572 | The gene SYN1 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Here, we show that the nNOS adapter protein, [protein encoded by NOS1AP], interacts with synapsins I, II, and III through an N-terminal phosphotyrosine-binding domain interaction, which leads to a ternary comp... | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01572","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SYN1 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Here, we show that the nNOS adapter pr... | |
medium_divergent_branch_01573 | PRKAA1 interacts with multiple partner genes. One specific interaction is supported by evidence stating: 'The AMPKbeta and AMPKgamma regulatory subunits were associated with AMPKalpha, but not with any of the AMPK-related kinases, explaining why AMP does not influence the activity of these enzymes.' Identify the cellul... | nucleotide-activated protein kinase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01573","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKAA1 interacts with multiple partner genes. One specific interaction is supported by evidence stating: 'The AMPKbeta and AMPKgamma regulatory subun... | |
medium_divergent_branch_01574 | GATA3 interacts with multiple proteins. One specific interaction involves a protein that physically associates with HIF-1α under hypoxic conditions to inhibit the ubiquitination and proteasomal degradation of HIF-1α, a process independent of HIF-1α prolyl hydroxylation. Which gene encodes this interacting protein? | Hypoxia-inducible factor 1-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01574","source_qa_id":"medium_divergent_branch_02764","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GATA3 interacts with multiple proteins. One specific interaction involves a protein that physical... | |
medium_divergent_branch_01575 | CARD9 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we identify the deubiquitinase [protein] as a novel regulator of CARD9, demonstrating that [protein] constitutively associates with CARD9 and removes TRIM62-deposited ubiquitin marks.' Which protein, connected to C... | Ubiquitin carboxyl-terminal hydrolase 15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01575","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CARD9 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we identify the deubiquitinase [protein] as... | |
medium_divergent_branch_01576 | PSMC3 interacts with multiple genes. One of these interaction partners was identified in a yeast two-hybrid screen where the full-length protein served as bait, yielding candidate interactors including beta-catenin, GRIM19, PSMC3, p62, and dynamin. Which disease is associated with this specific interacting gene? | male breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01576","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMC3 interacts with multiple genes. One of these interaction partners was identified in a yeast two-hybrid screen where the full-length protein serv... | |
medium_divergent_branch_01577 | PEX12 interacts with multiple peroxins. One specific interaction partner is characterized by the following evidence: 'In addition, we extend the list of peroxins with which human [this protein] interacts to include the PMP Pex16p and show that [this protein]'s CaaX prenylation motif is an important determinant in the a... | Zellweger spectrum disorders | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01577","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PEX12 interacts with multiple peroxins. One specific interaction partner is characterized by the following evidence: 'In addition, we extend the list... | |
medium_divergent_branch_01578 | UCP3 is associated with multiple molecular functions via the 'enables' relationship. One specific connection is supported by evidence stating: 'we show here that UCP2 and UCP3 are also highly active H(+) transporters.' Which biological process is connected to this specific molecular function through the 'part of' relat... | proton transmembrane transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01578","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UCP3 is associated with multiple molecular functions via the 'enables' relationship. One specific connection is supported by evidence stating: 'we sh... | |
medium_divergent_branch_01579 | SPTAN1 interacts with multiple spectrin beta subunits. One specific interaction is characterized by the binding of the alphaII subunit to a betaII form with high affinity (Kd 5-9 nM), which is significantly stronger than the interaction between alphaI and betaISigma1 (Kd 840 nM). Which protein, encoded by the gene corr... | Spectrin beta chain, non-erythrocytic 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01579","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SPTAN1 interacts with multiple spectrin beta subunits. One specific interaction is characterized by the binding of the alphaII subunit to a betaII fo... | |
medium_divergent_branch_01580 | RAD18 interacts with multiple proteins. One interaction partner is supported by evidence stating that the human RAD18 protein was found to interact with HHR6A and a second homolog. Which protein, connected to RAD18 via a binding interaction, is the subject of this specific evidence? | Ubiquitin-conjugating enzyme E2 B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01580","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD18 interacts with multiple proteins. One interaction partner is supported by evidence stating that the human RAD18 protein was found to interact w... | |
medium_divergent_branch_01581 | KLK14 is associated with multiple biological processes. One association is supported by evidence that KLK14 directly cleaves semenogelins I and II. Which biological process, connected to the process supported by this cleavage evidence via an 'is a' relationship, represents the broader category? | protein metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01581","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLK14 is associated with multiple biological processes. One association is supported by evidence that KLK14 directly cleaves semenogelins I and II. W... | |
medium_divergent_branch_01582 | BCL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro pulldown assay showed that the protein encoded by SQSTM1 directly interacted with Bcl-2.' Which protein is encoded by the gene corresponding to this interacting partner? | Sequestosome-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01582","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro pulldown assay showed that the protein encoded by ... | |
medium_divergent_branch_01583 | FOXO1 interacts with multiple proteins. One specific interaction involves an oncogenic subunit of the Skp1/Cul1/F-box protein ubiquitin complex that binds to, ubiquitinates, and promotes the degradation of FOXO1. Which protein product is encoded by the gene corresponding to this interacting partner? | S-phase kinase-associated protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01583","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXO1 interacts with multiple proteins. One specific interaction involves an oncogenic subunit of the Skp1/Cul1/F-box protein ubiquitin complex that ... | |
medium_divergent_branch_01584 | RAB11FIP2 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'All four interacting proteins associated with wild type Rab11a and dominant active Rab11a (Rab11aS20V) as well as Rab11b and this protein.' Which disease is connected to this interacting partner through a bioma... | clear cell renal carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01584","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB11FIP2 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'All four interacting proteins associate... | |
medium_divergent_branch_01586 | LBR interacts with multiple genes. One interaction is supported by evidence stating: 'Instead, LBR-TD exhibits tight and stoichiometric binding to the histone-fold region of unassembled, free histone H3, suggesting an interesting role in histone assembly.' Which disease is connected to the gene described by this eviden... | squamous cell lung carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01586","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LBR interacts with multiple genes. One interaction is supported by evidence stating: 'Instead, LBR-TD exhibits tight and stoichiometric binding to th... | |
medium_divergent_branch_01587 | MAP3K2 interacts with multiple genes. One specific interaction is supported by evidence showing that the expression of JNK1, JNKK2, and MEKK2 significantly augmented the coprecipitation of MEKK2-JNKK2, MEKK2-JNK1, and JNKK2-JNK1, indicating a synergistic interaction among these proteins. Which disease is associated wit... | rheumatoid arthritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01587","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K2 interacts with multiple genes. One specific interaction is supported by evidence showing that the expression of JNK1, JNKK2, and MEKK2 signifi... | |
medium_divergent_branch_01588 | DUSP10 interacts with multiple gene products. One of these interactions is supported by evidence stating that MKP-7 binds to and inactivates p38 MAPK and JNK, but not ERK. Which protein is encoded by the gene product connected to DUSP10 via this specific interaction? | Mitogen-activated protein kinase 9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01588","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DUSP10 interacts with multiple gene products. One of these interactions is supported by evidence stating that MKP-7 binds to and inactivates p38 MAPK... | |
medium_divergent_branch_01589 | LYN interacts with multiple genes. One interaction is supported by evidence stating: 'In addition, the two molecules were detected in p53/56(Lyn) immunoprecipitates, and Lyn kinase was found to specifically bind the C-terminal proline-rich sequence of Cas in an in vitro binding assay.' Which disease is connected to the... | Hodgkins lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_01589","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LYN interacts with multiple genes. One interaction is supported by evidence stating: 'In addition, the two molecules were detected in p53/56(Lyn) imm... |
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